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https://www.readbyqxmd.com/read/28550812/molecular-characterization-of-human-adenoviruses-in-urban-wastewaters-using-next-generation-and-sanger-sequencing
#1
M Iaconelli, B Valdazo-González, M Equestre, A R Ciccaglione, C Marcantonio, S Della Libera, G La Rosa
Human adenoviruses (HAdVs) are of major public health importance and are associated with a variety of clinical manifestations, including gastroenteritis, respiratory, ocular and urinary tract infections. To study the occurrence, prevalence and diversity of HAdV species and types circulating in Italy, we conducted a large-scale molecular-epidemiological investigation, a yearlong monitoring of 22 wastewater treatment plants, covering 10 Italian regions, representative of northern, central, and southern Italy...
May 19, 2017: Water Research
https://www.readbyqxmd.com/read/28550448/towards-xeno-free-cultures-of-human-limbal-stem-cells-for-ocular-surface-reconstruction
#2
Zala Lužnik, Claudia Breda, Vanessa Barbaro, Stefano Ferrari, Angelo Migliorati, Enzo Di Iorio, Barbara Ferrari, Carlo Griffoni, Andrea Grassetto, Hossein Mostafa Elbadawy, Marina Bertolin
Isolated limbal epithelial stem cells (LESCs) were cultured with or without a 3T3 murine fibroblast feeder-layer (FL) in 4 different culture media on culture plates or on denuded human amniotic membrane (AM) support and fibrin gel support: (1) control medium supplemented with fetal bovine serum; (2) control medium supplemented with the synthetic serum "XerumFree™ XF205" (XF); (3) CnT-20 medium supplemented with "XerumFree™ XF205" (CnT-XF) and (4) CnT-20 medium supplemented with human AB serum (CnT-AB). The three xenogeneic media were compared to standard condition (control + FL) and parameters assessed included cell morphology, proliferative potential, number of passages, assessment of clonogenic and abortive colonies, life span, ∆Np63α expression and epithelial morphology on AM...
May 26, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28549901/degradation-of-proteoglycan-4-lubricin-by-cathepsin-s-potential-mechanism-for-diminished-ocular-surface-lubrication-in-sj%C3%A3-gren-s-syndrome
#3
Suresh C Regmi, Michael L Samsom, Miriam Heynen, Gregory D Jay, Benjamin D Sullivan, Sruthi Srinivasan, Barbara Caffery, Lyndon Jones, Tannin A Schmidt
Sjögren's syndrome (SS) is an autoimmune disease affecting the lacrimal and salivary glands with hallmark clinical symptoms of dry eye and dry mouth. Recently, markedly increased cathepsin S (CTSS) activity has been observed in the tears of SS patients. Proteoglycan 4 (PRG4), also known as lubricin, is an effective boundary lubricant that is naturally present on the ocular surface. While PRG4 is susceptible to proteolytic digestion, the potential effect of CTSS on PRG4 remains unknown. The objective of this study was to assess the ability of CTSS to enzymatically degrade purified PRG4, and PRG4 naturally present in human tears, and alter ocular surface boundary lubricating properties...
May 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28549900/four-decades-of-ocular-renin-angiotensin-and-kallikrein-kinin-systems-1977-2017
#4
REVIEW
Rajko Igić
This review offers a contemporary history of the renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems with emphasis on how these complex systems affect the eye. It describes the types of communication (cross-talk) between the two systems and evaluates their potential role in the development of diabetic retinopathy, diabetic macular edema, age-related macular degeneration, glaucoma, and uveitis. In addition to detailing the important physiological actions of components of the RAS and KKS, possibilities are suggested for new therapeutic avenues in the treatment of common ocular diseases...
May 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28549843/topical-coenzyme-q10-demonstrates-mitochondrial-mediated-neuroprotection-in-a-rodent-model-of-ocular-hypertension
#5
Benjamin Michael Davis, Kailin Tian, Milena Pahlitzsch, Jonathan Brenton, Nivedita Ravindran, Gibran Butt, Giulia Malaguarnera, Eduardo Normando, Li Guo, Maria Francesca Cordeiro
Coenzyme Q10 (CoQ10) is a mitochondrial-targeted antioxidant with known neuroprotective activity. Its ocular effects when co-solubilised with α-tocopherol polyethylene glycol succinate (TPGS) were evaluated. In vitro studies confirmed that CoQ10 was significantly protective in different retinal ganglion cell (RGC) models. In vivo studies in Adult Dark Agouti (DA) rats with unilateral surgically-induced ocular hypertension (OHT) treated with either CoQ10/TPGS micelles or TPGS vehicle twice daily for three weeks were performed, following which retinal cell health was assessed in vivo using DARC (Detection of Apoptotic Retinal Cells) and post-mortem with Brn3a histological assessment on whole retinal mounts...
May 23, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28549517/association-between-tumor-regression-rate-and-gene-expression-profile-after-iodine-125-plaque-radiotherapy-for-uveal-melanoma
#6
Prithvi Mruthyunjaya, Michael I Seider, Sandra Stinnett, Amy Schefler
PURPOSE: Gene expression profile (GEP) testing segregates uveal melanoma (UM) into 2 main prognostic classes. It is unknown if a greater tumor regression response after iodine 125 (I(125)) brachytherapy correlates with class 2 GEP status. The purpose of this study was to determine whether there is a significant relationship between the rate of UM height regression and GEP classification testing after I(125) plaque brachytherapy. DESIGN: Multicenter, retrospective cohort study...
May 23, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28549348/ocular-toxicities-associated-with-targeted-anticancer-agents-an-analysis-of-clinical-data-with-management-suggestions
#7
Chen Fu, Dan S Gombos, Jared Lee, Goldy C George, Kenneth Hess, Andrew Whyte, David S Hong
Ocular toxicities are among the most common adverse events resulting from targeted anticancer agents and are becoming increasingly relevant in the management of patients on these agents. The purpose of this study is to provide a framework for management of these challenging toxicities based on objective data from FDA labels and from analysis of the literature. All oncologic drugs approved by the FDA up to March 14, 2015, were screened for inclusion. A total of 16 drugs (12 small-molecule drugs and 4 monoclonal antibodies) were analyzed for ocular toxicity profiles based on evidence of ocular toxicity...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549092/the-effect-of-spectacle-lenses-containing-peripheral-defocus-on-refractive-error-and-horizontal-eye-shape-in-the-guinea-pig
#8
Hannah E Bowrey, Guang Zeng, Dennis Y Tse, Amelia J Leotta, Yi Wu, Chi-Ho To, Christine F Wildsoet, Sally A McFadden
Purpose: It has been proposed that the peripheral retina, responding to local optical defocus, contributes to myopia and associated altered eye growth in humans. To test this hypothesis, we measured the changes in central (on-axis) and peripheral ocular dimensions in guinea pigs wearing a concentric bifocal spectacle lens design with power restricted to the periphery. Methods: Five groups of guinea pigs (n = 83) wore either a unifocal (UF) spectacle lens (-4, 0, or +4 Diopters [D]), or a peripheral defocus (PF) spectacle lens that had a plano center (diameter of 5 mm) with either -4 or +4 D in the surround (-4/0 or +4/0 D)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549089/development-of-a-sustained-release-voriconazole-containing-thermogel-for-subconjunctival-injection-in-horses
#9
Rosemary S Cuming, Eva M Abarca, Sue Duran, Anne A Wooldridge, Allison J Stewart, William Ravis, R Jayachandra Babu, Yuh-Jing Lin, Terri Hathcock
Purpose: To determine in vitro release profiles, transcorneal permeation, and ocular injection characteristics of a voriconazole-containing thermogel suitable for injection into the subconjunctival space (SCS). Methods: In vitro release rate of voriconazole (0.3% and 1.5%) from poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) thermogel was determined for 28 days. A Franz cell diffusion chamber was used to evaluate equine transcorneal and transscleral permeation of voriconazole (1...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549019/ocular-genetics-in-taiwan
#10
Yu-Hung Lai, Kwou-Yeung Wu
PURPOSE OF REVIEW: Ocular genetics is an emerging specialty which has accompanied the advancement of modern genetic technology. This review is to understand the current status of practice in ocular genetics in Taiwan. RECENT FINDINGS: There is only one ocular genetics clinic in Taiwan. Certified clinical laboratories provide few gene tests in ocular genetics. Most ocular genetic study is focused on myopia. Financial obstacles are a major problem for patients to seek gene tests...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28549018/intimate-partner-violence-in-ophthalmology-a-global-call-to-action
#11
Ali R Cohen, Lynette M Renner, Erin M Shriver
PURPOSE OF REVIEW: Intimate partner violence (IPV) is a leading cause of death and disability worldwide. Despite increasing public awareness of IPV, little information is available regarding the prevalence, associated injury patterns, and impact of IPV as a mechanism of ocular and orbital trauma. The purpose of this review is to summarize the literature regarding the impact of IPV in ophthalmology and provide team members with guidance on appropriate practices for screening and referral...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28548906/beyond-the-bowel-extraintestinal-manifestations-of-inflammatory-bowel-disease
#12
Jeffrey D Olpin, Brett P Sjoberg, Sarah E Stilwill, Leif E Jensen, Maryam Rezvani, Akram M Shaaban
Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated inflammation of the gastrointestinal tract. IBD includes two major disease entities: Crohn disease and ulcerative colitis. Imaging plays an important role in the diagnosis and surveillance of these complex disorders. Computed tomographic and magnetic resonance enterographic techniques have been refined in recent years to provide a superb means of evaluating the gastrointestinal tract for suspected IBD. Although the intestinal imaging manifestations of IBD have been extensively discussed in the radiology literature, extraintestinal imaging manifestations of IBD have received less attention...
May 26, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28548582/bilateral-iris-depigmentation-and-ocular-hypotony-as-end-stage-manifestations-of-untreated-vogt-koyanagi-harada-disease
#13
Miguel Cuevas, Alejandra de-la-Torre, Andrea Córdoba
PURPOSE: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt-Koyanagi-Harada disease. METHODS: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. RESULTS: Vogt-Koyanagi-Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony...
May 26, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28547797/vitamin-d-receptor-agonists-regulate-ocular-developmental-angiogenesis-and-modulate-expression-of-dre-mir-21-and-vegf
#14
Stephanie L Merrigan, Breandán N Kennedy
BACKGROUND AND PURPOSE: Pathological growth of ocular vasculature networks can underpin visual impairment in neovascular age-related macular degeneration, proliferative diabetic retinopathy and retinopathy of prematurity. Our aim was to uncover novel pharmacological regulators of ocular angiogenesis by phenotype-based screening in zebrafish. EXPERIMENTAL APPROACH: A bioactive chemical library of 465 drugs was screened to identify small molecule inhibitors of ocular hyaloid vasculature (HV) angiogenesis in zebrafish larvae...
May 26, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28547534/a-cross-sectional-comparative-study-on-chronic-ocular-manifestations-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-chinese-eyes-a-15-year-case-series
#15
Loraine L W Chow, Alex L K Ng, Sharon S W Chow, Bonnie N K Choy, Kendrick C Shih, Ian Y H Wong, Johnny C Y Chan, Jimmy S M Lai
PURPOSE: To compare the chronic ocular manifestations in Stevens-Johnson syndrome and toxic epidermal necrolysis patients from a 15-year cohort. METHODS: All SJS and TEN patients admitted to our burn intensive care unit between 1999 and 2014 were invited for assessment. Slit-lamp examination was performed, and ocular condition was graded according to the Sotozono scoring System, which depended on the extent of cornea, conjunctiva and lid involvement. Tear osmolarity was also measured...
May 25, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28547004/ocular-arterial-occlusive-disorders-and-carotid-artery-disease
#16
Sohan Singh Hayreh, M Bridget Zimmerman
OBJECTIVE: To compare prevalence of carotid artery disease and its various types of lesions in different types of ocular arterial occlusive disorders. DESIGN: Cohort study. SUBJECTS: 614 consecutive patients (728 eyes) with ocular arterial occlusive disorders. METHODS: At first visit, all patients had a detailed ophthalmic and medical history, comprehensive ophthalmic evaluation, and carotid artery evaluation (by Doppler/angiography) on the side of ocular arterial occlusion, and echocardiography...
January 2017: Ophthalmol Retina
https://www.readbyqxmd.com/read/28546937/ocular-manifestation-and-their-associated-factors-among-hiv-aids-patients-receiving-highly-active-antiretroviral-therapy-in-southern-ethiopia
#17
Anteneh Amsalu, Kindie Desta, Demiss Nigussie, Demoze Delelegne
AIM: To assess the pattern of ocular manifestation and associated factors among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients on highly active antiretroviral therapy (HAART) at Hawassa University Referral Hospital, Southern Ethiopia. METHODS: A cross sectional study was conducted from January 2014 to April 2015. After obtaining informed written consent, 240 adult HIV/AIDS patients on HAART were randomly selected regardless of their ophthalmic symptoms, WHO status or CD4 count...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546930/implantation-of-trabecular-micro-bypass-stent-using-a-novel-landing-strip-technique
#18
Cindy X Zheng, Marlene R Moster, Priyanka Gogte, Yang Dai, Remy S Manzi, Michael Waisbourd
AIM: To describe a novel technique of creating a landing strip within the trabecular meshwork to guide trabecular micro-bypass stent (iStent) implantation in patients who underwent phacoemulsification. METHODS: Thirty-four eyes from 30 patients who underwent iStent implantation after phacoemulsification from May 2014 to February 2015 were included in our retrospective study. All iStents were implanted via the "landing strip" technique. A 25-gauge microvitreoretinal blade was used to bisect the trabecular meshwork to less than 1 clock-hour, effectively creating a landing strip...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546924/the-expressions-of-metadherin-and-lef-1-in-mucosa-associated-lymphoid-tissue-lymphoma-of-ocular-adnexal
#19
Dan Qi, Hong Lin, Yan Gao, Jing Lin, Li-Ting Hu, Gui-Qiu Zhao
AIM: To investigate the expressions of metadherin (astrocyte elevated gene-1, AEG-1) and lymphoid enhancer-binding factor-1 (LEF-1) in ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. METHODS: The expressions of AEG-1 and LEF-1 were detected on specimens harvested from patients suffering from MALT lymphoma and lymphadenosis of ocular adnexal in Ophthalmology Department, Affiliated Hospital of Qingdao University from 2000 to 2015 by immunohistochemical and polymerase chain reaction (PCR) analysis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546920/ocular-penetration-of-topically-applied-1-tigecycline-in-a-rabbit-model
#20
Yasar Sakarya, Rabia Sakarya, Muammer Ozcimen, Sertan Goktas, Serap Ozcimen, Ismail Alpfidan, Ismail Senol Ivacık, Erkan Erdogan, Servet Cetinkaya, Abdulkadir Bukus
AIM: To evaluate ocular penetration of topically applied 1% tigecycline. METHODS: Forty-two New Zealand White rabbits were divided into 3 groups. A 50 µL drop of 1% tigecycline was administered in group 1. In groups 2 and 3, the drop was administered every 15min for 60min (keratitis protocol). Aqueous humor samples in groups 1 and 2 were collected under general anesthesia at 15, 30, 45, 60, 120, and 180min after the last drop. All animals in group 3 were euthanatized...
2017: International Journal of Ophthalmology
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