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https://www.readbyqxmd.com/read/29793126/effect-of-manual-therapy-versus-proprioceptive-neuromuscular-facilitation-in-dynamic-balance-mobility-and-flexibility-in-field-hockey-players-a-randomized-controlled-trial
#1
Gemma V Espí-López, Susana López-Martínez, Marta Inglés, Pilar Serra-Añó, Marta Aguilar-Rodríguez
OBJECTIVES: To compare the effectiveness of a specific Manual Therapy (MT) protocol applied to field hockey players (FHP), versus a Proprioceptive Neuromuscular Facilitation (PNF) protocol, in the improvement of dynamic balance, active range of movement and lumbar flexibility one-week and four-weeks after the treatment. DESIGN: Randomized controlled trial. Participants were assigned to 2 groups: MT and PNF. 30 min' sessions were performed once a week for three weeks...
April 22, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793053/aggressive-fluid-and-sodium-restriction-in-decompensated-heart-failure-with-preserved-ejection-fraction-results-from-a-randomized-clinical-trial
#2
Karina Sanches Machado d'Almeida, Eneida Rejane Rabelo-Silva, Gabriela Corrêa Souza, Melina Maria Trojahn, Sofia Louise Santin Barilli, Graziella Aliti, Luís Eduardo Rohde, Andreia Biolo, Luís Beck-da-Silva
OBJECTIVES: Sodium and fluid restriction is commonly prescribed for heart failure patients. However, its role in the treatment of heart failure with preserved ejection fraction (HFpEF) remains unclear. The aim of this study was to compare the effect of a diet with sodium and fluid restriction with an unrestricted diet in patients admitted for decompensated HFpEF. METHODS: Patients were randomized to a diet with sodium (0.8 g/d) and fluid (800 mL/d) restriction (intervention group [IG]) or an unrestricted diet (control group [CG]) and followed for 7 d or hospital discharge...
March 21, 2018: Nutrition
https://www.readbyqxmd.com/read/29793002/rasch-analysis-suggested-that-items-from-the-template-for-intervention-description-and-replication-tidier-checklist-can-be-summed-to-create-a-score
#3
Tie P Yamato, Chris G Maher, Bruno T Saragiotto, Mark J Catley, Anne M Moseley
OBJECTIVE: The aim of this study was to construct and evaluate a summary score of reporting completeness based on the Template for Intervention Description and Replication (TIDieR). STUDY DESIGN AND SETTING: We included 200 reports published in 2013 randomly selected from the Physiotherapy Evidence Database (PEDro). We summed the scores for the 12 items for the intervention and control groups for each trial in order to create a summary score from 0 to 24. Rasch analysis was used to investigate the item hierarchy, category function and reliability of the TIDieR checklist and determine the extent to which the summary score can be considered an interval-level measure...
May 21, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29792940/a-randomized-control-trial-to-determine-the-effectiveness-and-physiological-effects-of-spinal-manipulation-and-spinal-mobilization-compared-to-each-other-and-a-sham-condition-in-patients-with-chronic-low-back-pain-study-protocol-for-the-relief-study
#4
Brian C Clark, David W Russ, Masato Nakazawa, Christopher R France, Stevan Walkowski, Timothy D Law, Megan Applegate, Niladri Mahato, Samuel Lietkam, James Odenthal, Daniel Corcos, Simeon Hain, Betty Sindelar, Robert J Ploutz-Snyder, James S Thomas
BACKGROUND: Low back pain (LBP) is one of the most common reasons for seeking medical care. Manipulative therapies are a common treatment for LBP. Few studies have compared the effectiveness of different types of manipulative therapies. Moreover, the physiologic mechanisms underlying these treatments are not fully understood. Herein, we present the study protocol for The Researching the Effectiveness of Lumbar Interventions for Enhancing Function Study (The RELIEF Study). METHODS AND STUDY DESIGN: The RELIEF Study is a Phase II RCT with a nested mechanistic design...
May 21, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29792929/recent-advances-in-intra-articular-drug-delivery-systems-for-osteoarthritis-therapy
#5
REVIEW
Pierre Maudens, Olivier Jordan, Eric Allémann
Osteoarthritis (OA) is the most common degenerative disease of the joint. Despite many reports and numerous clinical trials, OA is not entirely understood, and there is no effective treatment available for this disease. To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections...
May 21, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29792887/auditory-priming-improves-neural-synchronization-in-auditory-motor-entrainment
#6
Jewel E Crasta, Michael H Thaut, Charles W Anderson, Patricia L Davies, William J Gavin
Neurophysiological research has shown that auditory and motor systems interact during movement to rhythmic auditory stimuli through a process called entrainment. This study explores the neural oscillations underlying auditory-motor entrainment using electroencephalography. Forty young adults were randomly assigned to one of two control conditions, an auditory-only condition or a motor-only condition, prior to a rhythmic auditory-motor synchronization condition (referred to as combined condition). Participants assigned to the auditory-only condition (auditory-first group) listened to 400 trials of auditory stimuli presented every 800ms, while those in the motor-only condition (motor-first group) were asked to tap rhythmically every 800ms without any external stimuli...
May 21, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29792839/patient-choice-of-adjunctive-non-pharmacologic-pain-management-during-first-trimester-abortion-a-randomized-controlled-trial
#7
Mary Tschann, Jennifer Salcedo, Reni Soon, Bliss Kaneshiro
OBJECTIVE: To determine if offering patients a choice of adjunctive non-pharmacologic pain management during first-trimester aspiration abortion results in lower pain scores than seen without offering these additional measures. STUDY DESIGN: We enrolled women receiving first-trimester aspiration abortion at the University of Hawai'i. We randomized patients to standard care (control), or standard care plus a choice of non-pharmacologic pain management options (intervention)...
May 21, 2018: Contraception
https://www.readbyqxmd.com/read/29792756/uterine-or-paracervical-lidocaine-application-for-pain-control-during-intrauterine-contraceptive-device-insertion-a-meta-analysis-of-randomised-controlled-trials
#8
Faustino R Perez-Lopez, Samuel J Martinez-Dominguez, Gonzalo R Perez-Roncero, Adrian V Hernandez
OBJECTIVE: Systematic review and meta-analysis to assess the effects of uterine or paracervical lidocaine application on pain control during IUD insertion. METHODS: PubMed and five other electronic research databases were searched through 15 November 2017 for RCTs comparing lidocaine treatment vs. a control (placebo or no-intervention) to prevent pain during IUD insertion. Searched terms included 'IUD insertion', 'lidocaine' and 'randomised controlled trial'. RCTs evaluating lidocaine treatment before IUD insertion without restriction of language, age and IUD type...
May 24, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29792733/feasibility-and-acceptability-of-nurse-led-primary-palliative-care-for-older-adults-with-chronic-conditions-a-pilot-study
#9
Shigeko Seiko Izumi, Basilia Basin, Margo Presley, Jean McCalmont, Jon P Furuno, Brie Noble, Judith G Baggs, J Randall Curtis
BACKGROUND: Many older adults live with serious illness for years before their death. Nurse-led primary palliative care could improve their quality of life and ability to stay in their community. OBJECTIVES: To assess feasibility and acceptability of a nurse-led Transitional Palliative Care (TPC) program for older adults with serious illness. METHODS: The study was a pilot trial of the TPC program in which registered nurses assisted patients with symptom management, communication with care providers, and advance care planning...
May 24, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29792556/effect-of-wii-training-on-hand-function-in-children-with-hemiplegic-cerebral-palsy
#10
Shamekh Mohamed El-Shamy, Mohamed Fawzy El-Banna
OBJECTIVE: The purpose of this study was to investigate the effect of Wii training on hand function in children with hemiplegic cerebral palsy. METHODS: A randomized controlled trial was conducted in 40 children with hemiplegic cerebral palsy (8-12 years). The experimental group received Wii training involving four games for 40 minutes a day, three times a week for 12 weeks plus usual care. The control group received usual care alone. Outcomes were spasticity measured using the modified Ashworth scale, grip strength measured using dynamometry, and hand function measured using the Peabody developmental motor scale (2nd ed...
May 24, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29792554/effect-of-acetazolamide-and-methazolamide-on-diaphragm-and-dorsiflexor-fatigue-a-randomized-controlled-trial
#11
Paolo B Dominelli, Chris J McNeil, Tyler Dennis Vermeulen, Troy J R Stuckless, Courtney V Brown, Giulio S Dominelli, Erik Richard Swenson, Lucas J Teppema, Glen Edward Foster
Acetazolamide, a carbonic anhydrase (CA) inhibitor used clinically and to prevent acute mountain sickness, worsens skeletal muscle fatigue in animals and humans. In animals, methazolamide, a methylated analogue of acetazolamide and an equally potent CA inhibitor, reportedly exacerbates fatigue less than acetazolamide. Accordingly, we sought to determine, in humans, if methazolamide would attenuate diaphragm and dorsiflexor fatigue compared to acetazolamide. Healthy men (dorsiflexor: n=12; diaphragm: n=7) performed fatiguing exercise on three occasions, after ingesting acetazolamide (250 mg three times a day) and then in random order, methazolamide (100 mg twice a day) or placebo for 48 h...
May 24, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29792533/efficacy-of-the-resilience-and-adjustment-intervention-after-traumatic-brain-injury-a-randomized-controlled-trial
#12
Jeffrey S Kreutzer, Jennifer H Marwitz, Adam P Sima, Ana Mills, Nancy H Hsu, Herman R Lukow
OBJECTIVE: Examine a psychoeducational and skill-building intervention's effectiveness for individuals after traumatic brain injury (TBI), using a two-arm, parallel, randomized, controlled trial with wait-listed control. METHODS: The Resilience and Adjustment Intervention (RAI) targets adjustment challenges and emphasizes education, skill-building and psychological support. Overall, 160 outpatients were randomly assigned to a treatment or wait-list control (WLC) group...
May 24, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29792492/evaluation-of-second-step-on-early-elementary-students-academic-outcomes-a-randomized-controlled-trial
#13
Clayton R Cook, Sabina Low, Joanne Buntain-Ricklefs, Kelly Whitaker, Michael D Pullmann, Jaclyn Lally
Research has consistently linked social-emotional learning to important educational and life outcomes. Early elementary represents an opportune developmental period to proactively support children to acquire social-emotional skills that enable academic success. Using data from a large scale randomized controlled trial, the purpose of this study was to investigate the impact of the 4th edition of Second Step on early elementary students' academic-related outcomes. Participants were Kindergarten to 2nd grade students in 61 schools (310 teachers; 7,419 students) across six school districts in Washington State and Arizona...
May 24, 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29792372/sativex%C3%A2-as-add-on-therapy-vs-further-optimized-first-line-antispastics-savant-in-resistant-multiple-sclerosis-spasticity-a-double-blind-placebo-controlled-randomised-clinical-trial
#14
Jolana Markovà, Ute Essner, Bülent Akmaz, Marcella Marinelli, Christiane Trompke, Arnd Lentschat, Carlos Vila Silván
Purpose/aim: To evaluate the efficacy of tetrahydrocannabinol [THC]:cannabidiol [CBD] oromucosal spray (Sativex®) as add-on therapy to optimized standard antispasticity treatment in patients with moderate to severe multiple sclerosis (MS) spasticity. METHODS: Sativex as Add-on therapy Vs. further optimized first-line ANTispastics (SAVANT) was a two-phase trial. In Phase A, eligible patients received add-on THC:CBD spray for 4 weeks to identify initial responders (≥ 20% improvement from baseline in spasticity 0-10 numerical rating scale [NRS] score)...
May 24, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29792370/efficacy-and-safety-of-intravenous-belimumab-in-japanese-patients-with-systemic-lupus-erythematosus-a-subgroup-analysis-of-a-phase-3-randomized-placebo-controlled-trial
#15
Yoshiya Tanaka, Damon Bass, Myron Chu, Sally Egginton, Beulah Ji, Herbert Struemper, David Roth
OBJECTIVES: To assess the efficacy and safety of intravenous belimumab plus standard systemic lupus erythematosus (SLE) therapy (SoC) in Japanese patients with SLE. METHODS: A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, randomized 2:1 to belimumab 10 mg/kg plus SoC or placebo plus SoC to Week 48. RESULTS: Sixty of 707 randomized patients were enrolled from study centers in Japan (belimumab, n = 39; placebo, n = 21)...
May 24, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29792294/training-working-memory-in-adolescents-using-serious-game-elements-pilot-randomized-controlled-trial
#16
Wouter J Boendermaker, Thomas E Gladwin, Margot Peeters, Pier J M Prins, Reinout W Wiers
BACKGROUND: Working memory capacity has been found to be impaired in adolescents with various psychological problems, such as addictive behaviors. Training of working memory capacity can lead to significant behavioral improvements, but it is usually long and tedious, taxing participants' motivation to train. OBJECTIVE: This study aimed to evaluate whether adding game elements to the training could help improve adolescents' motivation to train while improving cognition...
May 23, 2018: JMIR Serious Games
https://www.readbyqxmd.com/read/29792288/tralokinumab-for-severe-uncontrolled-asthma-stratos-1-and-stratos-2-two-randomised-double-blind-placebo-controlled-phase-3-clinical-trials
#17
Reynold A Panettieri, Ulf Sjöbring, AnnaMaria Péterffy, Peter Wessman, Karin Bowen, Edward Piper, Gene Colice, Christopher E Brightling
BACKGROUND: Tralokinumab is an anti-interleukin-13 human monoclonal antibody developed for the treatment of severe, uncontrolled asthma. These clinical trials aimed to assess the efficacy and safety of tralokinumab in this population. METHODS: STRATOS 1 and STRATOS 2 were randomised, double-blind, parallel-group, placebo-controlled, phase 3 clinical trials that enrolled participants aged 12-75 years with severe asthma that was inadequately controlled despite use of inhaled corticosteroids (≥500 μg per day fluticasone or equivalent) and a long-acting β2 agonist (but not oral corticosteroids)...
May 18, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29792287/safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-glpg1690-a-novel-autotaxin-inhibitor-to-treat-idiopathic-pulmonary-fibrosis-flora-a-phase-2a-randomised-placebo-controlled-trial
#18
Toby M Maher, Ellen M van der Aar, Olivier Van de Steen, Lisa Allamassey, Julie Desrivot, Sonia Dupont, Liesbeth Fagard, Paul Ford, Ann Fieuw, Wim Wuyts
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. People with IPF have increased concentrations of autotaxin in lung tissue and lysophosphatidic acid (LPA) in bronchoalveolar lavage fluid and exhaled condensate. GLPG1690 (Galapagos, Mechelen, Belgium) is a novel, potent, selective autotaxin inhibitor with good oral exposure. We explored the effects of GLPG1690 in patients with IPF. METHODS: This was a randomised, double-blind, placebo-controlled phase 2a study done in 17 centres in Italy, Ukraine and the UK...
May 18, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29792285/associations-between-trunk-postural-control-in-walking-and-unstable-sitting-at-various-levels-of-task-demand
#19
Julian C Acasio, Courtney M Butowicz, Pawel R Golyski, Maury A Nussbaum, Brad D Hendershot
Trunk postural control (TPC) has been investigated in several populations and tasks. Previous work observed targeted training of TPC via isolated trunk control tasks may improve performance in other activities (e.g., walking). However, the nature of this relationship remains unknown. We therefore investigated the relationship between TPC, at both the global (i.e., response to finite perturbations) and local (i.e., resistance to continuous perturbations) levels, during walking and unstable sitting, both at varying levels of task demand...
May 21, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29792242/testing-a-stepped-care-model-for-binge-eating-disorder-a-two-step-randomized-controlled-trial
#20
Giorgio A Tasca, Diana Koszycki, Agostino Brugnera, Livia Chyurlia, Nicole Hammond, Kylie Francis, Kerri Ritchie, Iryna Ivanova, Genevieve Proulx, Brian Wilson, Julie Beaulac, Hany Bissada, Erin Beasley, Nancy Mcquaid, Renee Grenon, Benjamin Fortin-Langelier, Angelo Compare, Louise Balfour
BACKGROUND: A stepped care approach involves patients first receiving low-intensity treatment followed by higher intensity treatment. This two-step randomized controlled trial investigated the efficacy of a sequential stepped care approach for the psychological treatment of binge-eating disorder (BED). METHODS: In the first step, all participants with BED (n = 135) received unguided self-help (USH) based on a cognitive-behavioral therapy model. In the second step, participants who remained in the trial were randomized either to 16 weeks of group psychodynamic-interpersonal psychotherapy (GPIP) (n = 39) or to a no-treatment control condition (n = 46)...
May 24, 2018: Psychological Medicine
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