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https://www.readbyqxmd.com/read/28342814/tear-cytokine-profile-of-glaucoma-patients-treated-with-preservative-free-or-preserved-latanoprost
#1
Jose M Martinez-de-la-Casa, Francisco Perez-Bartolome, Elena Urcelay, Jose L Santiago, Javier Moreno-Montañes, Pedro Arriola-Villalobos, Jose M Benitez-Del-Castillo, Julian Garcia-Feijoo
PURPOSE: To determine variations in cytokine levels of glaucoma patients treated either with preservative-free latanoprost or preserved latanoprost, relative to healthy individuals. METHODS: Tear samples were collected from 39 healthy subjects, 20 glaucoma patients treated with preserved latanoprost, and 20 patients treated with preservative-free latanoprost. A set of 27 inflammatory cytokines was analyzed in each group, including interleukin (IL)-1β, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, eotaxin, fibroblast growth factor (FGF) basic, granulocyte colony stimulating factor (G-CSF), granulocyte monocyte colony stimulating factor (GM-CSF), interferon (IFN)-γ, interferon gamma-induced protein (IP)-10, monocyte chemo attractant protein (MCP)-1MCAF, macrophage inflammatory protein (MIP)-1α, MIP-1β, platelet-derived growth factor (PDGF)-BB, regulated on activation, normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF)-α and vascular endothelial growth factor (VEGF)...
March 22, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28342719/association-of-structural-and-functional-measures-with-contrast-sensitivity-in-glaucoma
#2
Nima Fatehi, Sara Nowroozizadeh, Sharon Henry, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
PURPOSE: To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN: Cross-sectional prospective study. METHODS: 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses...
March 22, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28342558/high-intensity-focused-ultrasound-as-first-line-treatment-in-patients-with-chronic-angle-closure-glaucoma-at-risk-for-malignant-glaucoma
#3
M Graber, Z Khoueir, A Beauchet, N Benhatchi, S Hammoud, Y Lachkar
PURPOSE: Evaluation of high intensity focused ultrasound (HIFU) transscleral cyclocoagulation as an alternative to trabeculectomy in the treatment of refractory chronic angle closure glaucoma (CACG). METHODS: This prospective one armed single center pilot study was conducted on patients with medically uncontrolled CACG who underwent high intensity focused ultrasound (HIFU) cyclocoagulation as first line surgical treatment, using the Eye-OP1 HIFU device (Eyetechcare-Rillieux-la-Pape, France) driven by ultrasound biomicroscopic (UBM) ciliary body localization...
March 22, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28340421/cannabis-use-patterns-and-motives-a-comparison-of-younger-middle-aged-and-older-medical-cannabis-dispensary-patients
#4
Nancy A Haug, Claudia B Padula, James E Sottile, Ryan Vandrey, Adrienne J Heinz, Marcel O Bonn-Miller
INTRODUCTION: Medical cannabis is increasingly being used for a variety of health conditions as more states implement legislation permitting medical use of cannabis. Little is known about medical cannabis use patterns and motives among adults across the lifespan. METHODS: The present study examined data collected at a medical cannabis dispensary in San Francisco, California. Participants included 217 medical cannabis patients who were grouped into age-defined cohorts (younger: 18-30, middle-aged: 31-50, and older: 51-72)...
March 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28339389/basics-of-sterile-compounding-ophthalmic-preparations-part-2-suspensions-and-ointments
#5
Loyd V Allen
Ophthalmic preparations are used to treat allergies, bacterial and viral infections, glaucoma, and numerous other eye conditions. When the eye's natural defensive mechanisms are compromised or overcome, an ophthalmic preparation, in a solution, suspension, or ointment form, may be indicated, with solutions being the most common form used to deliver a drug to the eye. This article discusses ophthalmic suspensions and ointments and represents part 2 of a 2-part article, the first of which discussed ophthalmic solutions...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28339375/basics-of-sterile-compounding-ophthalmic-preparations-part-1-ophthalmic-solutions
#6
Loyd V Allen
Ophthalmic preparations are used to treat allergies, bacterial and viral infections, glaucoma, and numerous other eye conditions. When the eye's natural defensive mechanisms are compromised or overcome, an ophthalmic preparation, in a solution, suspension, or ointment form, may be indicated, with solutions being the most common form used to deliver a drug to the eye. This article provides a general discussion on ophthalmic preparations and specifically discusses the preparation of solutions.
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28339073/identification-of-proteins-in-the-aqueous-humor-associated-with-cataract-development-using-itraq-methodology
#7
Minhong Xiang, Xingru Zhang, Qingsong Li, Hanmin Wang, Zhenyong Zhang, Zhumei Han, Meiqing Ke, Xingxing Chen
Proteins in the aqueous humor (AH) are important in the induction of cataract development. The identification of cataract-associated proteins assists in identifying patients and predisposed to the condition and improve treatment efficacy. Proteomics analysis has previously been used for identifying protein markers associated with eye diseases; however, few studies have examined the proteomic alterations in cataract development due to high myopia, glaucoma and diabetes. The present study, using the isobaric tagging for relative and absolute protein quantification methodology, aimed to examine cataract-associated proteins in the AH from patients with high myopia, glaucoma or diabetes, and controls...
March 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28337343/long-term-outcomes-of-primary-trabeculectomy-in-diabetic-patients-without-retinopathy-with-primary-angle-closure-glaucoma
#8
Jian Liu, Miaomiao Zhang, Bin Li, Jianrong Wang
Purpose. To evaluate primary trabeculectomy with adjunctive mitomycin-C (MMC) in diabetic patients without retinopathy with primary angle-closure glaucoma (PACG). Design. This is a retrospective case series comparison. Participants. This retrospective trial compared outcomes of 88 eyes that underwent trabeculectomy in patients with diabetes mellitus (DM) without retinopathy and in 97 patients without DM. Methods. In this study, the intraocular pressure (IOP), visual acuity, visual field, and postoperative complications were compared between the two groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28337061/an-introduction-to-darc-technology
#9
REVIEW
Syed Shoeb Ahmad
Glaucoma is a multi-factorial neurodegenerative disorder. The common denominator in all types of glaucomas is retinal ganglion cell death through apoptosis. However, this cellular demise in glaucoma is detected late by structural or functional analyses. There can be a 10-year delay prior to the appearance of visual field defects and pre-perimetric glaucoma is an issue still being addressed. However, a new cutting-edge technology called detection of apoptosing retinal cells (DARC) is being developed. This technique is capable of non-invasive, real-time visualization of apoptotic changes at the cellular level...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28336675/evolving-risk-factors-and-antibiotic-sensitivity-patterns-for-microbial-keratitis-at-a-large-county-hospital
#10
Haoxing Jin, Walter T Parker, Nathan W Law, Cameron L Clarke, Jordan D Gisseman, Stephen C Pflugfelder, Li Wang, Zaina N Al-Mohtaseb
Purpose: To identify the risk factors, causative organisms, antimicrobial susceptibility and outcomes of microbial keratitis in a large county hospital in Houston, Texas. Design: Case series. METHODS: Setting: A large county hospital in Houston, Texas. Study Population: Patients with known diagnosis of microbial keratitis from January 2011 to May 2015. Observation Procedure: Retrospective chart review. Main Outcomes: Epidemiology, risk factors, outcomes and antibiotic susceptibility of microbial keratitis...
March 23, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28336283/-early-efficacy-of-dexamethasone-implant-ozurdex-%C3%A2-in-diabetic-macular-edema-real-life-study
#11
V Sarda, F Fajnkuchen, S Nghiem-Buffet, T Grenet, G Chaine, A Giocanti-Auregan
PURPOSE: To assess early efficacy of dexamethasone intravitreal implant 0.7mg (OZURDEX(®)) at the time of peak efficacy (2 months after injection) in patients with decreased visual acuity secondary to diabetic macular edema (DME). MATERIALS AND METHODS: Retrospective monocentric study. Inclusion criteria were best-corrected visual acuity (BCVA)≤70 letters (20/40) due to DME and central retinal thickness (CRT)≥300 microns (Cirrus 2, Carl Zeiss Meditec, Inc, Dublin)...
March 20, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28334804/a-critical-role-of-hrd1-in-the-regulation-of-optineurin-degradation-and-aggresome-formation
#12
Jiahui Mao, Qin Xia, Chunfeng Liu, Zheng Ying, Hongfeng Wang, Guanghui Wang
Mutations in optineurin (OPTN) are associated with several human disorders including amyotrophic lateral sclerosis (ALS) and primary open-angle glaucoma (POAG). OPTN is known to be a multifunctional autophagy receptor that plays important roles in NF-κB signaling, vesicle trafficking, maintenance of the Golgi apparatus and autophagy. Given that a loss of neurons and an abnormal aggregation of disease proteins are two key features of neurodegenerative diseases, protein quality control systems are considered to be tightly associated with neurodegeneration...
March 11, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28333942/comparison-of-self-measured-diurnal-intraocular-pressure-profiles-using-rebound-tonometry-between-primary-angle-closure-glaucoma-and-primary-open-angle-glaucoma-patients
#13
Shaoying Tan, Nafees Baig, Linda Hansapinyo, Vishal Jhanji, Shihui Wei, Clement C Tham
PURPOSE: To document the diurnal intraocular pressure (IOP) profile with rebound tonometry performed by primary glaucoma patients in non-clinic environment. PATIENTS AND METHODS: Fifty-three medically-treated eyes of 31 primary angle closure glaucoma (PACG) and 22 primary open angle glaucoma (POAG) patients with no previous eye surgery were recruited. Diurnal IOP was measured 5 times per day at four-hourly intervals from 08:00 to 24:00 for 1 week in patients' study eye using rebound tonometry in a non-clinic environment...
2017: PloS One
https://www.readbyqxmd.com/read/28333898/efficacy-of-combined-retisert-and-ahmed-glaucoma-valve-for-medically-uncontrolled-uveitis-and-glaucoma
#14
Kelvin H Wan, Dennis S C Lam
No abstract text is available yet for this article.
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333896/relationship-of-optic-nerve-structure-and-function-to-peripapillary-vessel-density-measurements-of-optical-coherence-tomography-angiography-in-glaucoma
#15
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Srilakshmi Dasari, Mohammed Riyazuddin, Sharanya Raveendran, Narendra K Puttaiah, Jayasree P Venugopal, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To evaluate the sectoral and global structure-structure (vessel density-retinal nerve fiber layer thickness) and structure-function (vessel density-visual sensitivity loss) relationships of peripapillary vessel density measurements on optical coherence tomography angiography in primary open-angle glaucoma and to determine if fractional polynomial (FP) models characterize the relationships better than linear models. MATERIALS AND METHODS: In a cross-sectional study, structure-structure and structure-function relationships of peripapillary vessel densities were determined in 227 eyes of 143 subjects (63 control and 164 primary open-angle glaucoma eyes) who had undergone standard automated perimetry and optical coherence tomography testing within 6 months of each other, using linear and FP models...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333895/visual-field-defects-in-young-patients-with-open-angle-glaucoma-comparison-between-high-tension-and-normal-tension-glaucoma
#16
Ji-Hye Park, Chungkwon Yoo, Jinhwan Park, Yong Yeon Kim
PURPOSE: To investigate the clinical features of young Korean patients with open-angle glaucoma (OAG), and to compare visual field (VF) defects between patients with normal-tension glaucoma (NTG) and those with high-tension glaucoma (HTG). MATERIALS AND METHODS: Patients with OAG younger than 40 years of age were divided into NTG and HTG groups based on untreated intraocular pressure (IOP) level. The patients were matched according to the mean deviation of standard automated perimetry...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333894/m-s-smart-system-contrast-sensitivity-measurements-compared-with-standard-visual-function-measurements-in-primary-open-angle-glaucoma-patients
#17
Jessica L Liu, J Jason McAnany, Jacob T Wilensky, Ahmad A Aref, Thasarat S Vajaranant
PURPOSE: To evaluate the nature and extent of letter contrast sensitivity (CS) deficits in glaucoma patients using a commercially available computer-based system (M&S Smart System II) and to compare the letter CS measurements to standard clinical measures of visual function. METHODS: Ninety-four subjects with primary open-angle glaucoma participated. Each subject underwent visual acuity, letter CS, and standard automated perimetry testing (Humphrey SITA 24-2). All subjects had a best-corrected visual acuity (BCVA) of 0...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333893/magnetic-resonance-imaging-characteristics-of-a-baerveldt-glaucoma-implant
#18
Daniel M Anderson, Ryan B Schwope, Michael J Reiter, Abraham W Suhr
PURPOSE: Evaluate for normative postoperative magnetic resonance imaging (MRI) characteristics of a Baerveldt Glaucoma Implant (BGI). DESIGN: Prospective case series. PARTICIPANTS: Seven subjects with uncontrolled glaucoma requiring a primary superotemporal BGI. METHODS: Subjects prospectively underwent sequential MRI orbital scans without contrast at 0 to 2 weeks, 6 to 8 weeks, and 4 to 6 months after implantation of a BGI model 103-250...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333892/the-effects-of-phacoemulsification-on-intraocular-pressure-and-topical-medication-use-in-patients-with-glaucoma-a-systematic-review-and-meta-analysis-of-3-year-data
#19
James J Armstrong, Tomas Wasiuta, Efstathia Kiatos, Monali Malvankar-Mehta, Cindy M L Hutnik
PURPOSE: For patients with comorbid cataract and primary open-angle glaucoma (POAG), guidance is lacking as to whether cataract extraction and traditional filtering surgery should be performed as a staged or combined procedure. Achieving this guidance requires an evidence-based understanding of the effects of phacoemulsification alone on intraocular pressure (IOP) in patients with POAG. For this reason, a systematic review and meta-analysis was undertaken to synthesize evidence quantifying the effect of phacoemulsification on IOP and the required number of topical glaucoma medications in patients with cataract and POAG...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333891/sd-oct-choroidal-thickness-in-advanced-primary-open-angle-glaucoma
#20
Riccardo Sacconi, Niccolo' Deotto, Tommaso Merz, Roberta Morbio, Stefano Casati, Giorgio Marchini
PURPOSE: To assess the choroidal thickness in advanced primary open-angle glaucoma (POAG) comparing patients affected by advanced glaucoma and normal subject using spectral domain optical coherence tomography (SD-OCT). METHODS: In total, 35 eyes of 35 patients affected by POAG with advanced perimetric defect (mean deviation worse than -12 dB) were prospectively enrolled and underwent a complete ophthalmologic examination, including enhanced depth imaging SD-OCT...
March 22, 2017: Journal of Glaucoma
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