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Zhixi Li, Xinxing Guo, Ou Xiao, Pei Ying Lee, Ran Liu, Decai Wang, Padmaja Sankaridurg, Mingguang He
SIGNIFICANCE: Some studies reported that optic disc tilt and rotation might be risk factors for the susceptibility of high myopic eyes to develop glaucoma. However, data regarding optic disc manifestations in high myopia participants are few. It is crucial to characterize the features of optic disc manifestations among high myopes. PURPOSE: To describe optic disc characteristics of Chinese highly myopic eyes and to investigate associated factors. METHODS: This cross-sectional, observational study included 890 Chinese with bilateral high myopia (defined as ≤-6...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Bright S Ashimatey, Brett J King, Victor E Malinovsky, William H Swanson
SIGNIFICANCE: Glaucomatous nasal visual field abnormalities correspond to damage in the temporal raphe-where individual nerve bundles can be visualized. The ability to quantify structural abnormality in the raphe, with a clinically applicable protocol, sets the stage for investigating the raphe as a potential site for assessing early glaucoma. PURPOSE: To develop a clinically applicable imaging and analysis technique for identifying retinal nerve fiber bundle abnormalities in the temporal raphe...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Sung Uk Baek, Kwang Hyun Kim, Joo Yeon Lee, Kyung Wha Lee
PURPOSE: To assess long-term changes in intraocular pressure (IOP) and the development of glaucoma after early phacoemulsification in acute primary angle closure. METHODS: Retrospective chart review of acute primary angle closure patients treated with phacoemulsification in attack eyes versus fellow eyes. Within a month after the angle closure attack, all subjects underwent cataract surgery and were divided into two groups: group A received cataract surgery on their attack eyes...
March 19, 2018: Korean Journal of Ophthalmology: KJO
Tomoko Hasegawa, Hanako Ohashi Ikeda, Sachiko Iwai, Yuki Muraoka, Tatsuaki Tsuruyama, Keiko Okamoto-Furuta, Haruyasu Kohda, Akira Kakizuka, Nagahisa Yoshimura
Retinal neuronal cell death underlies many incurable eye diseases such as retinitis pigmentosa (RP) and glaucoma, and causes adult blindness. We have shown that maintenance of ATP levels via inhibiting ATP consumption is a promising strategy for preventing neuronal cell death. Here, we show that branched chain amino acids (BCAAs) are able to increase ATP production by enhancing glycolysis. In cell culture, supplementation of the culture media with BCAAs, but not glucose alone, enhanced cellular ATP levels, which was canceled by a glycolysis inhibitor...
February 2018: Heliyon
Kazuhiko Hayashi, Masashi Koto, Hiroaki Ikawa, Kazuhiko Ogawa, Tadashi Kamada
Purpose: To evaluate the efficacy and safety of carbon-ion radiotherapy (CIRT) for patients with lacrimal gland carcinomas (LGCs) with extraorbital extension. Results: The median follow-up period was 53.7 months. The 5-year local control and overall survival rates were 62% and 65%, respectively. Regarding late toxicities, 12 patients (36.4%) developed Grade 4 optic nerve disorders, including visual losses of the diseased side ( N = 8; 66.7%), and 1 patient (3.0%) developed a Grade 3 optic nerve disorder...
February 27, 2018: Oncotarget
Eric Wallace, Zachary Stewart, David Theriot, William Shaffer, Shane Guillory, Michael Hanemann, Raman Danrad, Bradley Spieler
Background: Plasmacytomas are monoclonal proliferations of plasma cells that typically affect the intramedullary axial skeleton. Imaging findings of an extramedullary plasmacytoma on radiograph and computed tomography can be nonspecific and can resemble other entities such as lymphoma, metastases, chondrosarcomas, or giant cell tumors. Case Report: A 60-year-old female with a medical history of partial complex seizures, hypertension, diabetes, glaucoma, and hyperlipidemia presented with complaints of superficial abdominal pain associated with erythema and swelling for 3 weeks...
2018: Ochsner Journal
Zhichao Wu, Felipe A Medeiros
Visual field testing is an important endpoint in glaucoma clinical trials, and the testing paradigm used can have a significant impact on the sample size requirements. To investigate this, this study included 353 eyes of 247 glaucoma patients seen over a 3-year period to extract real-world visual field rates of change and variability estimates to provide sample size estimates from computer simulations. The clinical trial scenario assumed that a new treatment was added to one of two groups that were both under routine clinical care, with various treatment effects examined...
March 20, 2018: Scientific Reports
Małgorzata Mulak, Wojciech A Czak, Małgorzata Mimier, Radosław Kaczmarek
BACKGROUND: Despite the development of various methods of intraocular pressure (IOP) measurement, Goldmann applanation tonometry (GAT) is still the most popular. The measurement using GAT depends on the biomechanical properties of the cornea, such as the thickness, the radius of curvature, as well as the amount of the fluorescein used. OBJECTIVES: The aim of the study was to compare IOP values measured by GAT with those measured by applanation resonance tonometry (ART)...
March 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Abdulaziz Anazi Alshamrani, Sami Al-Shahwan
BACKGROUND: Crouzon syndrome is the most common form of craniosynostosis, and mutations in the fibroblast growth factor receptor 2 and 3 (FGFR2 and FGFR3) genes are implicated in its pathogenesis. OBSERVATION: A 10-year-old female patient with Crouzon syndrome and congenital glaucoma treated with trabeculectomy and ocular hypotensive medications was examined. The patient had proptosis, exposure keratopathy, megalocornea, thin central corneal thickness, a shallow anterior chamber, mild anterior subcapsular cataract, and a cup-to-disc ratio of 0...
March 19, 2018: Journal of Glaucoma
Ji Won Kim, JaeSang Ko, Young Jun Woo, Hyoung Won Bae, Jin Sook Yoon
PURPOSE: To determine the prevalence of ocular hypertension (OHT) and open-angle glaucoma (OAG) in patients with GO and to investigate the associations between clinical features of the disease and the prevalence of OHT and OAG. METHODS: A cross-sectional analytic study was conducted among a total of 1128 patients with Graves' orbitopathy (GO). A complete ophthalmic examination was performed, including intraocular pressure, optic disc photography, visual field testing using a Humphrey visual field analyzer, and retinal nerve fiber layer thickness measured by optical coherence tomography...
March 19, 2018: Journal of Glaucoma
José Ignacio Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Bachar Kudsieh, Cristina Fernández-Vigo, José Ángel Fernández-Vigo, Julián García-Feijóo
PURPOSE: To describe the presence of anterior chamber angle (ACA) tissue as an incidental optical coherence tomography (OCT) finding in healthy children. METHODS: For this cross-sectional study, we reviewed Fourier domain OCT images obtained in 422 children as candidates for inclusion in a prior study who visited our clinic for a routine vision test. The presence of angle tissue was assessed in the nasal and temporal quadrants. On tomographies showing angle tissue, several measurements were made including ACA width and trabecular meshwork (TM) length and size...
March 19, 2018: Journal of Glaucoma
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To investigate the relationship between glaucomatous disc hemorrhage (DH) location with respect to the nasal or temporal margin of the retinal nerve fiber layer defect (RNFLD) and the direction of RNFLD widening. MATERIALS AND METHODS: This is a retrospective, cross-sectional study. Patients with any documented episode of glaucomatous DH throughout the follow-up period, and definite RNFLD widening on retinal nerve fiber layer (RNFL) photos were analyzed...
March 19, 2018: Journal of Glaucoma
Amit Kumar Purang, Madhu Bhoot, Julie Pegu, Monica Gandhi, Suneeta Dubey
No abstract text is available yet for this article.
March 19, 2018: Journal of Glaucoma
Andrew Bastawrous, Wanjiku Mathenge, John Buchan, Fatima Kyari, Tunde Peto, Hillary Rono, Helen A Weiss, David Macleod, Allen Foster, Matthew Burton, Hannah Kuper
PURPOSE: Glaucoma is a leading cause of blindness in people of African descent. Minimal data is available from African population-based cohort studies. The primary aims of this study were to describe the normative distribution of glaucoma features to enable glaucoma classification and to assess risk factors for those with glaucoma at follow-up among people aged ≥50 years in Kenya. MATERIALS AND METHODS: Random cluster sampling with probability proportionate to size was used to select a representative cross-sectional sample of adults aged ≥50 years in 2007-8 in Nakuru District, Kenya...
March 19, 2018: Journal of Glaucoma
Bo Ram Seol, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
No abstract text is available yet for this article.
March 19, 2018: Journal of Glaucoma
Adi Einan-Lifshitz, Avner Belkin, David Mathew, Nir Sorkin, Clara C Chan, Yvonne M Buys, Graham E Trope, David S Rootman
PURPOSE: To assess the long-term outcomes of GDD exposure repair with corneal lamellar patch graft covered by a buccal mucous membrane graft sutured to surrounding conjunctiva. METHODS: In this retrospective longitudinal study, the charts of all patients who underwent buccal mucous membrane grafts combined with corneal lamellar patch grafts for exposed GDD tubes between the years 2006 to 2013 were reviewed. A minimum follow-up of 3 years was required for inclusion...
March 19, 2018: Journal of Glaucoma
Lyndsay Brown, William Foulsham, Savva Pronin, Andrew J Tatham
PURPOSE: To examine the effect of corneal biomechanical properties on intraocular pressure (IOP) measurements obtained using a rebound self-tonometer (Icare HOME) compared to Goldmann applanation tonometry (GAT). METHODS: An observational study of 100 patients with glaucoma or ocular hypertension. All had a comprehensive ophthalmic examination and standard automated perimetry. IOP was assessed by GAT, Icare HOME and Ocular Response Analyzer (ORA), which was also used to assess corneal hysteresis (CH) and corneal resistance factor (CRF)...
March 19, 2018: Journal of Glaucoma
Shigeki Hashimoto, Chota Matsumoto, Mariko Eura, Sachiko Okuyama, Hiroki Nomoto, Fumi Tanabe, Tomoyasu Kayazawa, Aiko Iwase, Yoshikazu Shimomura
PURPOSE: To evaluate the distribution and progression of glaucomatous visual field (VF) defects with binocular vision. PATIENTS AND METHODS: Subjects were 167 patients (average age, 67±10.7▒y) with glaucoma who received the Humphrey 24-2 VF test (SITA-Standard) for the two eyes. Using the Best Location Algorithm, patient's integrated binocular VF (IVF) was calculated from their Humphrey 24-2 results. Of 167, 77 subjects (average age, 68±11.0▒y) also underwent monocular/binocular Humphrey Esterman tests...
March 19, 2018: Journal of Glaucoma
Zia S Pradhan, Shivani Dixit, Shruthi Sreenivasaiah, Harsha L Rao, Jayasree P Venugopal, Sathi Devi, Carroll A B Webers
PURPOSE: To study sectoral vessel density (VD) and structural alterations in the peripapillary and parafoveal hemiretina corresponding to perimetrically intact regions of glaucomatous eyes with hemifield defects and to compare these with healthy eyes using optical coherence tomography. METHODS: This cross-sectional study included 37 eyes with open-angle glaucoma having visual fields (VF) defects restricted to one hemifield and 45 age-matched controls. Peripapillary VD and retinal nerve fiber layer (RNFL) thickness were measured in 8 sectors...
March 19, 2018: Journal of Glaucoma
Su-Meng Liu, Ning-Li Wang, Zhen-Tao Zuo, Wei-Wei Chen, Di-Ya Yang, Zhen Li, Yi-Wen Cao
In accordance with the trans-lamina cribrosa pressure difference theory, decreasing the trans-lamina cribrosa pressure difference can relieve glaucomatous optic neuropathy. Increased intracranial pressure can also reduce optic nerve damage in glaucoma patients, and a safe, effective and noninvasive way to achieve this is by increasing the intra-abdominal pressure. The purpose of this study was to observe the changes in orbital subarachnoid space width and intraocular pressure at elevated intra-abdominal pressure...
February 2018: Neural Regeneration Research
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