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https://www.readbyqxmd.com/read/29351357/changes-in-axial-length-and-progression-of-visual-field-damage-in-glaucoma
#1
Mieko Yanagisawa, Takehiro Yamashita, Masato Matsuura, Yuri Fujino, Hiroshi Murata, Ryo Asaoka
Purpose: To investigate the relationship between axial length (AL) elongation and progression of primary open-angle glaucoma (POAG). Methods: AL was measured twice over a 5.1 ± 0.76 (mean ± standard deviation: SD) year period in 125 eyes of 72 patients with POAG. The eyes were divided into not long (AL < 26 mm, 80 eyes) and long (>26 mm, 45 eyes) groups. During this period, patients' visual fields (VFs) were measured with the Humphrey Field Analyzer 12.4 ± 7...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29351270/is-mytomicyn-better-than-5-fluorouracil-as-antimetabolite-in-trabeculectomy-for-glaucoma
#2
Eduardo Pimentel, Jimena Schmidt
INTRODUCTION: Trabeculectomy is considered the standard for glaucoma surgery. Postoperative scarring is one the factors associated with surgery failure. Different antimetabolites have been used in order to reduce this risk, particularly 5-fluorouracil and mitomycin C. Although both are considered effective, it is not clear if they are different in terms of success of trabeculectomy and adverse effects. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
January 18, 2018: Medwave
https://www.readbyqxmd.com/read/29350795/phacoemulsification-and-primary-implantation-with-bag-in-the-lens-intraocular-lens-in-children-with-unilateral-and-bilateral-cataract
#3
Alf Nyström, Nawaf Almarzouki, Gunilla Magnusson, Madeleine Zetterberg
PURPOSE: To report outcome in a paediatric cohort with cataract extraction and implantation of bag-in-the-lens intraocular lens (BIL-IOL). METHODS: Children younger than 16 years of age subjected to phacoemulsification with primary implantation of BIL-IOL during 2009 through 2013 were analysed retrospectively. Exclusion criteria were uveitis or ≤6 months of follow-up. RESULTS: In total, 109 eyes of 84 children were included; 40 unilateral and 44 bilateral cataracts...
January 19, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29350692/control-and-optimisation-of-fluid-flow-in-glaucoma-drainage-device-surgery
#4
Kin Sheng Lim
Avoidance of hypotony in the early post-operative phase following glaucoma drainage device surgery is paramount, if serious complications are to be avoided. Current strategies of preventing early hypotony are either a valve mechanism, as those found in Ahmed Glaucoma Valve or flow restrictor as used in Baerveldt or Molteno implants. The Ahmed glaucoma valve has a pre-tensioned valve which opens and closes at the pre-determined level of intra-ocular pressure. Although the opening and closing pressure can be slightly inconsistent, coinciding with the change of material used in the plate construction, the reliability appears to have improved in recent years...
January 19, 2018: Eye
https://www.readbyqxmd.com/read/29349523/prognostic-factors-of-pediatric-glaucoma-a-retrospective-study
#5
Marilita M Moschos, Eirini Nitoda, Isabelle Fenzel, Xuefei Song, Achim Langenbucher, Barbara Kaesmann, Berthold Seitz, Zisis Gatzioufas
PURPOSE: To correlate the features of certain types of infantile glaucoma with the progression and the prognosis of the disease, highlighting probable risk factors. METHODS: Seventy-six patients with pediatric glaucoma were recruited in this retrospective study. All patients underwent ophthalmological examination in the Department of Ophthalmology of the Saarland University Medical Center from January 2001 to December 2012. Our pediatric patients were classified into four different categories of glaucoma: (1) primary congenital glaucoma (presenting buphthalmus), (2) aniridia-related glaucoma, (3) Peters/Rieger's anomaly-related glaucoma and (4) congenital cataract-related glaucoma...
January 18, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29347941/a-five-year-retrospective-study-of-the-epidemiological-characteristics-and-visual-outcomes-of-pediatric-ocular-trauma
#6
Edita Puodžiuvienė, Giedrė Jokūbauskienė, Monika Vieversytė, Kirwan Asselineau
BACKGROUND: Pediatric trauma can lead to serious visual impairment as a result of the trauma itself or secondary to amblyopia. Precise data on epidemiological characteristics and visual outcomes of pediatric ocular injuries are valuable for the prevention of monocular blindness. METHODS: A total of 268 cases of pediatric ocular trauma admitted to the Department of Ophthalmology of the Lithuanian University of Health Sciences Hospital from January 2008 to December 2013 were retrospectively reviewed...
January 18, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29346801/early-gene-expression-profile-in-retinal-ganglion-cell-layer-after-optic-nerve-crush-in-mice
#7
Satoru Ueno, Azusa Yoneshige, Yoshiki Koriyama, Man Hagiyama, Yoshikazu Shimomura, Akihiko Ito
Purpose: Optic nerve crush (ONC) induces retinal ganglion cell (RGC) death, which causes vision loss in glaucoma. To investigate early events leading to apoptosis of RGCs, we performed gene expression analysis of injured retinas in the period before RGC loss. Methods: The temporal changes of gene profiles at 0, 1, and 4 days after ONC were determined by DNA microarray. To verify the gene expression changes in RGCs, we enriched RGCs by laser-captured microdissection and performed real-time RT-PCR of 14 selected genes...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29344483/retinoinvasive-uveal-melanoma-report-of-2-cases-and-review-of-the-literature
#8
John P Gorham, Eszter Szalai, Jill R Wells, Hans E Grossniklaus
Purpose: To describe the clinical history and histopathologic findings of 2 cases of retinoinvasive uveal melanoma. Methods: The medical records and pathology specimens of 2 patients with retinoinvasive uveal melanoma were reviewed. Results: The first patient had an iris/ciliary body melanoma that was treated and the second patient had suspected iridocorneal endothelial syndrome. Both patients developed a blind, painful eye; the first patient's right eye was enucleated and the left eye of the second patient underwent evisceration...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29343781/ocular-and-clinical-characteristics-associated-with-the-extent-of-posterior-lamina-cribrosa-curve-in-normal-tension-glaucoma
#9
Seung Hyen Lee, Tae-Woo Kim, Eun Ji Lee, Michaël J A Girard, Jean Martial Mari, Robert Ritch
Although normal-tension glaucoma (NTG) is pathogenetically heterogenous, there have been few attempts to subclassify NTG patients according to the mechanism and anatomy of optic nerve damage. This cross-sectional study was performed to investigate differences in the clinical and ocular characteristics between NTG patient groups stratified according to the degree of posterior lamina cribrosa (LC) curve which was assessed by calculating LC curvature index (LCCI). A total of 101 eyes of 101 treatment naïve NTG patients were included...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342845/anesthetic-preconditioning-as-endogenous-neuroprotection-in-glaucoma
#10
Tsung-Han Chou, Ganeswara Rao Musada, Giovanni Luca Romano, Elizabeth Bolton, Vittorio Porciatti
Blindness in glaucoma is the result of death of Retinal Ganglion Cells (RGCs) and their axons. RGC death is generally preceded by a stage of reversible dysfunction and structural remodeling. Current treatments aimed at reducing intraocular pressure (IOP) are ineffective or incompletely effective in management of the disease. IOP-independent neuroprotection or neuroprotection as adjuvant to IOP lowering in glaucoma remains a challenge as effective agents without side effects have not been identified yet. We show in DBA/2J mice with spontaneous IOP elevation and glaucoma that the lifespan of functional RGCs can be extended by preconditioning RGCs with retrobulbar lidocaine in one eye at four months of age that temporary blocks RGC axonal transport...
January 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29342436/iris-melanoma-outcomes-based-on-the-american-joint-committee-on-cancer-classification-eighth-edition-in-432-patients
#11
Carol L Shields, Maura Di Nicola, Vladislav P Bekerman, Swathi Kaliki, Carolina Alarcon, Enzo Fulco, Jerry A Shields
PURPOSE: The American Joint Committee on Cancer (AJCC) classification was updated to the eighth edition in January 2017, providing staging for iris melanoma. This study evaluated outcomes of iris melanoma per the AJCC classification, eighth edition. DESIGN: Retrospective case series. PARTICIPANTS: Four hundred thirty-two patients with iris melanoma. METHODS: Management including tumor resection, plaque radiotherapy, or enucleation...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29342153/the-impact-of-optic-nerve-and-related-characteristics-on-disc-area-measurements-derived-from-different-imaging-techniques
#12
Michael Yapp, George Rennie, Michael P Hennessy, Michael Kalloniatis, Barbara Zangerl
PURPOSE: Optic nerve head (ONH) assessment and its interpretation in healthy patients and those with glaucoma remains a pivotal topic specifically considering rapid advancements in imaging technologies. We undertook a large-scale, mixed cohort, comparative study to assess the correlation of optic disc measurements between different imaging modalities and investigated the impact of patient and disc associated parameters. METHODS: ONH sizes were obtained from one randomly selected eye of each of 209 patients using stereophotography, confocal scanning laser ophthalmoscopy and two different optical coherence tomographers (OCT)...
2018: PloS One
https://www.readbyqxmd.com/read/29342127/enhancement-in-corneal-permeability-of-dissolved-carteolol-by-its-combination-with-magnesium-hydroxide-nanoparticles
#13
Noriaki Nagai, Sakie Yamaoka, Yuya Fukuoka, Miyu Ishii, Hiroko Otake, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura
We prepared magnesium hydroxide (MH) nanoparticles, and investigated their effect when combined with dissolved carteolol on the bioavailability and intraocular pressure (IOP)-reducing effect of carteolol. The carteolol was solved in saline containing additives (0.5% methylcellulose, 0.001% benzalkonium chloride, 0.5% mannitol; CRT-solution). MH nanoparticles were prepared by a bead mill method with additives. Then carteolol/MH microparticle and carteolol/MH nanoparticle fixed combinations (mCMFC and nCMFC) were prepared by mixing the CRT-solution and MH particles...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341922/sustained-release-timolol-maleate-loaded-ocusert-based-on-biopolymer-composite
#14
Revathy V Nair, Shefrin S, Akhil Suresh, Anoop K R, Sreeja C Nair
In the present investigation, the effect of timolol maleate loaded ocuserts was studied as an alternative for conventional anti-glaucoma formulation. Ocuserts were prepared using natural polymer sodium alginate and ethyl cellulose. Physico-chemical properties along with drug entrapment efficiency (94-98%), content uniformity (93.1% ± 0.264-98.00% ± 0.321), in vitro drug release (83.42% ± 0.35 at end of 12 hours), ex vivo permeation all showed satisfactory results, which was found to follow zero order kinetics...
January 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29341800/factors-associated-with-patient-satisfaction-in-an-outpatient-glaucoma-population
#15
Kamran Rahmatnejad, Jonathan S Myers, Megan E Falls, Sarah R Myers, Michael Waisbourd, Lisa A Hark
PURPOSE: To determine what metrics might impact satisfaction survey responses. METHODS: A 37-question survey was administered to 249 participants. Responses were correlated to demographics, clinical factors, weather conditions, and examination timing. RESULTS: Sample consists of 55.4% female and 73.9% white, and mean age was 65.1 years. Participants were assigned to: completely satisfied (77.9%) or not completely satisfied (22.1%) groups based on their rating of glaucoma specialist on a scale of 1-10, while 10 considered "completely satisfied" and less than 10 "not completely satisfied...
January 17, 2018: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29340640/in-vivo-three-dimensional-lamina-cribrosa-strains-in-healthy-ocular-hypertensive-and-glaucoma-eyes-following-acute-intraocular-pressure-elevation
#16
Meghna R Beotra, Xiaofei Wang, Tin A Tun, Liang Zhang, Mani Baskaran, Tin Aung, Nicholas G Strouthidis, Michaël J A Girard
Purpose: To compare in vivo lamina cribrosa (LC) strains (deformations) following acute IOP elevation in healthy, glaucoma, and ocular hypertensive subjects. Methods: There were 20 healthy, 20 high-tension primary open-angle glaucoma (POAG), 16 primary angle-closure glaucoma (PACG), and 20 ocular hypertensive (OHT; with normal visual fields) eyes studied. For each test eye, the optic nerve head was imaged three times (at baseline IOP, following an acute elevation of IOP to approximately 35 then 45 mm Hg using an ophthalmodynamomter) using optical coherence tomography (OCT)...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29340639/biomechanical-rigidity-and-quantitative-proteomics-analysis-of-segmental-regions-of-the-trabecular-meshwork-at-physiologic-and-elevated-pressures
#17
Janice A Vranka, Julia A Staverosky, Ashok P Reddy, Phillip A Wilmarth, Larry L David, Ted S Acott, Paul Russell, Vijay Krishna Raghunathan
Purpose: The extracellular matrix (ECM) of the trabecular meshwork (TM) modulates resistance to aqueous humor outflow, thereby regulating IOP. Glaucoma, a leading cause of irreversible blindness worldwide, is associated with changes in the ECM of the TM. The elastic modulus of glaucomatous TM is larger than age-matched normal TM; however, the biomechanical properties of segmental low (LF) and high flow (HF) TM regions and their response to elevated pressure, are unknown. Methods: We perfused human anterior segments at two pressures using an ex vivo organ culture system...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29339920/microhook-ab-interno-trabeculotomy-a-novel-minimally-invasive-glaucoma-surgery
#18
Masaki Tanito
Trabeculotomy (LOT) is performed to reduce the intraocular pressure in patients with glaucoma, both in children and adults. It relieves the resistance to aqueous flow by cleaving the trabecular meshwork and the inner walls of Schlemm's canal. Microhook ab interno LOT (µLOT), a novel minimally invasive glaucoma surgery, incises trabecular meshwork using small hooks that are inserted through corneal side ports. An initial case series reported that both µLOT alone and combination of µLOT and cataract surgery normalize the intraocular pressure during the early postoperative period in Japanese patients with glaucoma...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29339763/glucocorticoid-receptor-gr%C3%AE-regulates-glucocorticoid-induced-ocular-hypertension-in-mice
#19
Gaurang C Patel, Yang Liu, J Cameron Millar, Abbot F Clark
Prolonged glucocorticoid (GC) therapy can cause GC-induced ocular hypertension (OHT), which if left untreated progresses to iatrogenic glaucoma and permanent vision loss. The alternatively spliced isoform of glucocorticoid receptor GRβ acts as dominant negative regulator of GR activity, and it has been shown that overexpressing GRβ in trabecular meshwork (TM) cells inhibits GC-induced glaucomatous damage in TM cells. The purpose of this study was to use viral vectors to selectively overexpress the GRβ isoform in the TM of mouse eyes treated with GCs, to precisely dissect the role of GRβ in regulating steroid responsiveness...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339644/changes-in-central-macular-thickness-and-retinal-nerve-fiber-layer-thickness-in-eyes-with-vogt-koyanagi-harada-disease-a-2-year-follow-up-study
#20
Yong-Seop Han, Kyung-Sup Shin, Woo-Hyuk Lee, Jung-Yeul Kim
PURPOSE: To investigate the central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness in eyes with Vogt-Koyanagi-Harada (VKH) disease associated with optic disc swelling and serous retinal detachment through a 24-month follow-up period. METHODS: We prospectively investigated 28 eyes of 14 treatment-naïve patients with acute VKH disease associated with optic disc swelling and serous retinal detachment and 30 eyes of 15 normal individuals to compare changes in the CMT and average RNFL thickness...
January 16, 2018: Ophthalmologica. Journal International D'ophtalmologie
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