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Sjogren's

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https://www.readbyqxmd.com/read/28339625/cystatin-s-a-candidate-biomarker-for-severity-of-submandibular-gland-involvement-in-sj%C3%A3-gren-s-syndrome
#1
Daniela Martini, Alessia Gallo, Serena Vella, Francesca Sernissi, Antonella Cecchettini, Nicoletta Luciano, Enza Polizzi, Pier Giulio Conaldi, Marta Mosca, Chiara Baldini
Objectives.: Salivary cystatin S is a defence protein mainly produced by submandibular glands and involved in innate oral immunity. This study aimed to verify whether cystatin S was diversely expressed in different disease subsets of primary Sjogren's syndrome (pSS) patients, defined on the basis of salivary flow [unstimulated salivary flow rate (USFR)], minor salivary gland (MSG) focus score and submandibular gland ultrasonography abnormalities. We also evaluated miR-126 and miR-335-5p expression in MSG biopsies to verify whether an aberrant regulation of cystatin S at the glandular level may influence its salivary expression...
February 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339495/microrna-expression-profiles-identify-disease-specific-alterations-in-systemic-lupus-erythematosus-and-primary-sj%C3%A3-gren-s-syndrome
#2
Ji-Qing Chen, Gábor Papp, Szilárd Póliska, Krisztina Szabó, Tünde Tarr, Bálint László Bálint, Péter Szodoray, Margit Zeher
The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28337967/one-year-in-review-2017-primary-sj%C3%A3-gren-s-syndrome
#3
REVIEW
Francesco Ferro, Elisa Marcucci, Martina Orlandi, Chiara Baldini, Elena Bartoloni-Bocci
Primary Sjögren's syndrome (pSS) is a complex and heterogeneous disease. Last year, a great deal of basic and clinical research was carried out in pSS. Following the previous reviews of this publishing series, we will herewith provide a critical digest of the most recent literature on pSS pathogenesis, clinical manifestations and treatment. More specifically, we will focus on the heterogeneity of the disease, on the underlying pathogenetic pathways and on the possible new targeted treatments on the horizon...
March 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28330998/comparison-of-performance-of-the-2016-acr-eular-classification-criteria-for-primary-sj%C3%A3-gren-s-syndrome-with-other-sets-of-criteria-in-japanese-patients
#4
Hiroto Tsuboi, Shinya Hagiwara, Hiromitsu Asashima, Hiroyuki Takahashi, Tomoya Hirota, Hisashi Noma, Hisanori Umehara, Atsushi Kawakami, Hideki Nakamura, Hajime Sano, Kazuo Tsubota, Yoko Ogawa, Etsuko Takamura, Ichiro Saito, Hiroko Inoue, Seiji Nakamura, Masafumi Moriyama, Tsutomu Takeuchi, Yoshiya Tanaka, Shintaro Hirata, Tsuneyo Mimori, Isao Matsumoto, Takayuki Sumida
OBJECTIVES: To compare the performance of the new 2016 American College of Rheumatology (ACR)-European League Against Rheumatism (EULAR) classification criteria for primary Sjögren's syndrome (SS) with 1999 revised Japanese Ministry of Health criteria for diagnosis of SS (JPN), 2002 American-European Consensus Group classification criteria for SS (AECG) and 2012 ACR classification criteria for SS (ACR) in Japanese patients. METHODS: The study subjects were 499 patients with primary SS (pSS) or suspected pSS who were followed up in June 2012 at 10 hospitals in Japan...
March 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28330683/insight-into-pathogenesis-of-sj%C3%A3-gren-s-syndrome-dissection-on-autoimmune-infiltrates-and-epithelial-cells
#5
Andreas V Goules, Efstathia K Kapsogeorgou, Athanasios G Tzioufas
Sjögren's syndrome (SS) is a chronic autoimmune disease with broad clinical spectrum, extending from benign exocrinopathy to severe systemic disease and lymphoma development. The glandular and extraglandular dysfunction of SS is associated with lymphocytic infiltrates that invade the epithelial structures of affected organs. The in-depth study of autoimmune lesions in the minor salivary glands (MSG), which are the major target-organ of SS responses, revealed that the lymphocytic infiltrates vary in severity and composition among SS-patients, are full-blown at diagnosis and remain unchanged thereafter...
March 19, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28330507/is-admittance-to-specialised-palliative-care-among-cancer-patients-related-to-sex-age-and-cancer-diagnosis-a-nation-wide-study-from-the-danish-palliative-care-database-dpd
#6
Mathilde Adsersen, Lau Caspar Thygesen, Anders Bonde Jensen, Mette Asbjoern Neergaard, Per Sjøgren, Mogens Groenvold
BACKGROUND: Specialised palliative care (SPC) takes place in specialised services for patients with complex symptoms and problems. Little is known about what determines the admission of patients to SPC and whether there are differences in relation to institution type. The aims of the study were to investigate whether cancer patients' admittance to SPC in Denmark varied in relation to sex, age and diagnosis, and whether the patterns differed by type of institution (hospital-based palliative care team/unit, hospice, or both)...
March 23, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28326738/-dental-implantation-in-a-patient-with-sj%C3%A3-gren-s-syndrome-a-case-report
#7
Luo Cuifen, Peng Guoguang, Feng Yuanhua, Huang Xingxiang
We reported one case of a patient with Sjögren's syndrome and dental implant. This patient was followed up for more than one year. The patient was diagnosed with Sjögren's syndrome for 5 years and treated with long-term corticosteroid. Four implant-tissue interface hydrophilic implants were placed on 15, 16, 44, and 46 of the mandibular and maxillary areas. After the surgery was completed, the patient was treated with oral antibiotic and "shenggu pills" to prevent infection and glucocorticoid to manage Sjögren's syndrome...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326325/a-potential-of-sfasl-in-preventing-gland-injury-in-sjogren-s-syndrome
#8
Jiao Luo, Ying Wang, Bing Yu, Hongyan Qian, Yan He, Guixiu Shi
Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process of cell apoptosis. FasL consists of two forms, membrane FasL (mFasL) and soluble FasL (sFasL). sFasL can be produced by mFasL cleaved by matrix metalloproteinases (MMP) and also reveals a role for binding to Fas which is expressed on cell surface. Although Fas/FasL axis has been implicated in a variety of diseases, its role in Sjogren's syndrome still remains ill defined. In this study, we investigated the potential of sFasL in the pathogenesis of Sjogren's syndrome (SS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28324200/prevalence-and-characterization-of-non-sicca-onset-primary-sj%C3%A3-gren-syndrome-with-interstitial-lung-involvement
#9
Manfredi Andreina, Sebastiani Marco, Cerri Stefania, Cassone Giulia, Bellini Pietrantonio, Della Casa Giovanni, Luppi Fabrizio, Ferri Clodoveo
Primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD) involved about 10-20% of patients. In 20% of cases, ILD can be diagnosed before pSS; anyway, few studies have investigated the frequency of ILD as the first clinically relevant manifestation of pSS, generally referred to retrospective studies. Aim of our prospective study was to describe prevalence, clinical, serological, and instrumental features of non-sicca onset pSS patients with interstitial lung involvement. During a period of 48 months, all consecutive patients diagnosed as pSS were enrolled...
March 21, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28323371/diffusional-kurtosis-imaging-of-parotid-glands-in-sj%C3%A3-gren-s-syndrome-initial-findings
#10
Chen Chu, Huayong Zhang, Nan Zhou, Xin Dou, Ming Li, Song Liu, Yun Zhu, Chun Wang, Weibo Chen, Queenie Chan, Lingyun Sun, Jian He, Zhengyang Zhou
PURPOSE: To explore the role of diffusion kurtosis imaging (DKI) of parotid glands in diagnosing Sjögren's syndrome (SS). MATERIALS AND METHODS: A total of 40 patients with SS and 40 healthy volunteers underwent 3.0T magnetic resonance imaging (MRI) including DKI, which generated the apparent diffusion coefficient (ADC), corrected diffusion (D), and diffusional kurtosis (K) values. The MR nodular grade was determined on the basis of MR morphological findings. RESULTS: The parotid ADC, D, and K values in patients with SS were significantly higher than those of healthy volunteers (P = 0...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28323025/ability-to-predict-resting-energy-expenditure-with-six-equations-compared-to-indirect-calorimetry-in-octogenarian-men
#11
Mikael Karlsson, Erika Olsson, Wulf Becker, Brita Karlström, Tommy Cederholm, Per Sjögren
The accuracy of predictive equations for calculating resting energy expenditure (REE) in elderly people has been questioned. Aging is associated with progressive declines in REE, which partly is explained by loss of fat free mass (FFM). Against this background we aimed to identify the most accurate predictive equation for REE in octogenarian men, taking body composition into account and using indirect calorimetry as reference value. REE was measured in 22 men (mean age 82.6±0.3years) and compared with six predictive equations: two based on FFM and four based on body weight, height and/or age...
March 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28321568/gastrointestinal-and-liver-lesions-in-primary-childhood-sj%C3%A3-gren-syndrome
#12
Yasuyo Kashiwagi, Tatsuro Hatsushika, Norito Tsutsumi, Soken Go, Shigeo Nishimata, Hisashi Kawashima
Sjögren syndrome (SS) is characterized by lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary glands, leading to keratoconjunctivitis sicca and xerostomia. SS is one of the most common autoimmune rheumatic diseases in adults; however, few cases of primary childhood SS with gastrointestinal and liver lesions have been reported in the literature. We report five cases of primary childhood SS with gastrointestinal and liver lesions. Multiple gastric biopsies in four cases revealed atrophic gastritis in the antrum of the stomach or chronic gastritis...
March 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28315833/predictive-factors-for-the-placebo-effect-in-clinical-trials-for-dry-eye-a-pooled-analysis-of-three-clinical-trials
#13
Takahiro Imanaka, Izumi Sato, Shiro Tanaka, Koji Kawakami
BACKGROUND: Placebo effect is one of the methodological difficulties in dry eye clinical trials. If we could elucidate the tendencies of the placebo response and find predictors, we could reduce the placebo response in clinical trials for dry eye. In this study, we investigated the predictive factors for the placebo effect in dry eye clinical trials. METHODS: A total of 205 patients with dry eye assigned to the placebo arms of three placebo-controlled randomised clinical trials were analysed by simple and multivariable regression analysis...
March 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314382/erratum-to-a-randomized-double-blind-placebo-controlled-clinical-trial-of-fluoride-varnish-in-preventing-dental-caries-of-sj%C3%A3-gren-s-syndrome-patients
#14
Weini Xin, Katherine Chiu Man Leung, Edward Chin Man Lo, Mo Yin Mok, Moon Ho Leung
No abstract text is available yet for this article.
March 17, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28301413/ophthalmic-findings-in-late-stage-sjogren-larsson-syndrome
#15
Tavish Nanda, Jaclyn L Kovach
PURPOSE: To report spectral domain optical coherence tomography and fundus autofluorescence documentation of late stage macular findings associated with Sjogren-Larsson Syndrome in three adult siblings. METHODS: Three adult siblings with Sjogren-Larsson Syndrome underwent ophthalmic examination and imaging. RESULTS: Crystalline maculopathy and subretinal deposits, presumably lipofuscin accumulation, with macular atrophy were present in varying degrees in all three adult siblings...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28300881/frontal-fibrosing-alopecia-in-association-with-sj%C3%A3-gren-s-syndrome-more-than-a-simple-coincidence
#16
Karina Colossi Furlan, Priscila Kakizaki, Juliana Cabral Nunes Chartuni, Neusa Yuriko Sakai Valente
Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Since then the number of reported cases has increased significantly. Coexistence of frontal fibrosing alopecia and autoimmune disorders - such as discoid erythematosus lupus and Sjögren's syndrome - may suggest a common pathogenic background among the diseases...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28298559/the-risk-of-deep-venous-thrombosis-and-pulmonary-embolism-in-primary-sj%C3%A3-gren-syndrome-a-general-population-based-study
#17
J Antonio Aviña-Zubieta, Michael Jansz, Eric C Sayre, Hyon K Choi
OBJECTIVE: To estimate the future risk and time trends of venous thromboembolism (VTE) in individuals with newly diagnosed primary Sjögren syndrome (pSS) in the general population. METHODS: Using a population database that includes all residents of British Columbia, Canada, we created a study cohort of all patients with incident SS and up to 10 controls from the general population matched for age, sex, and entry time. We compared incidence rates (IR) of pulmonary embolism (PE), deep vein thrombosis (DVT), and VTE between the 2 groups according to SS disease duration...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28296257/randomized-controlled-trial-of-rituximab-and-cost-effectiveness-analysis-in-treating-fatigue-and-oral-dryness-in-primary-sjogren-s-syndrome
#18
Simon J Bowman, Colin C Everett, John L O'Dwyer, Paul Emery, Costantino Pitzalis, Wan-Fai Ng, Colin T Pease, Elizabeth J Price, Nurhan Sutcliffe, Nagui St Gendi, Frances C Hall, Sharon P Ruddock, Catherine Fernandez, Catherine Reynolds, Claire T Hulme, Kevin A Davies, Christopher J Edwards, Peter C Lanyon, Robert J Moots, Euthalia Roussou, Ian P Giles, Linda D Sharples, Michele Bombardieri
OBJECTIVE: We investigated whether rituximab, an anti-B-cell therapy, improved symptoms of fatigue and oral dryness in patients with Primary Sjögren's Syndrome (PSS). METHODS: Multicentre, randomised, double-blind, parallel-group placebo-controlled trial, including Health Economic Analysis. Anti-Ro positive patients with PSS, symptomatic fatigue and oral dryness were recruited from 25 UK rheumatology clinics from August 2011 to January 2014. Patients were centrally-randomised to either placebo IV or rituximab IV (1000mg in 250mL) at weeks 0, 2, 24 and 26, with pre-and post-infusion medication including corticosteroids...
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28296253/rituximab-in-the-treatment-of-sj%C3%A3-gren-s-syndrome-is-it-the-wrong-drug
#19
EDITORIAL
Hendrika Bootsma, Frans G M Kroese, Arjan Vissink
No abstract text is available yet for this article.
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28292174/extrahepatic-manifestations-of-primary-biliary-cholangitis
#20
REVIEW
Sara L Chalifoux, Peter G Konyn, Gina Choi, Sammy Saab
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of the intrahepatic bile ducts, leading to cholestasis. PBC is known to have both hepatic and extrahepatic manifestations. Extrahepatic manifestations are seen in up to 73% of patients with PBC, with the most common being Sjogren's syndrome, thyroid dysfunction and systemic sclerosis. It is thought that patients with PBC are at increased risk of developing these extrahepatic manifestations, almost all of which are autoimmune, because patients with autoimmune disease are at higher risk of developing another autoimmune condition...
March 16, 2017: Gut and Liver
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