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https://www.readbyqxmd.com/read/27911920/sirna-targeting-mtor-effectively-prevents-the-proliferation-and-migration-of-human-lens-epithelial-cells
#1
Chunmei Zhang, Jingjing Liu, Na Jin, Guiming Zhang, Yahui Xi, Hongling Liu
Posterior capsule opacification (PCO) is the most common complication that causes visual decrease after extracapsular cataract surgery. The primary cause of PCO formation is the proliferation of the residual lens epithelial cells (LECs). The mammalian target of rapamycin (mTOR) plays an important role in the growth and migration of LECs. In the current study, we used small interfering RNA (siRNA) to specifically attenuate mTOR in human lens epithelial B3 cells (HLE B3). We aimed to examine the effect of mTOR-siRNA on the proliferation, migration and epithelial-to-mesenchymal transition (EMT) of HLE B3 cells and explore the underlying mechanisms...
2016: PloS One
https://www.readbyqxmd.com/read/27911426/-ocular-hydrodynamics-after-phacoemulsification-cataract-surgery-in-patients-with-primary-open-angle-glaucoma
#2
E A Kalizhnikova, O I Lebedev, O V Shchipacheva, G G Pecheritsa
AIM: To investigate parameters of intraocular fluid outflow after phacoemulsification of cataract in patients with primary open-angle glaucoma (POAG). MATERIAL AND METHODS: The study involved 153 cataract patients (153 eyes), most of whom also had POAG. The patients were divided into three groups: group 1 - 51 patients (51 eyes) with cataract but no glaucoma, group 2 - 51 patients (51 eyes) with cataract and early POAG, and group 3 - 51 patients (51 eyes) with cataract and advanced POAG...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27911420/-role-of-immunological-factors-in-the-development-of-myopic-choroidal-neovascularization
#3
A G Shchuko, N V Zaitseva, T N Yur'eva, E R Chernykh, I M Mikhalevich, A V Grigor'eva
AIM: To study the concentration of cytokines in the aqueous humor of the anterior chamber in patients with myopic choroidal neovascularization (mCNV) and to compare the results to their ophthalmic status. MATERIAL AND METHODS: A total of 19 patients (19 eyes) with mCNV treated with intravitreal ranibizumab were included in the study. The control group consisted of 15 patients (15 eyes) with myopia who had cataract surgery. Age, sex, and refractive error distribution were similar to that in the study group...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27906556/combination-effect-of-cefuroxime-and-levofloxacin-against-bacteria-isolated-from-the-healthy-conjunctival-sac-and-endophthalmitis-cases-using-a-fractional-inhibitory-concentration-index
#4
Takashi Suzuki, Toshihiro Yamamoto, Tomohiko Torikai, Yuichi Ohashi
PURPOSE: Intracameral cefuroxime (CXM) and antibiotic eye drops such as fluoroquinolone are widely used for preventing endophthalmitis after cataract surgery. However, few reports are available regarding their interactions. This study was conducted to examine the in vitro interaction of CXM and levofloxacin (LVFX) against bacterial isolates from the healthy conjunctival sac before cataract surgery and from endophthalmitis cases. METHODS: The activity of each drug was determined using a broth dilution method...
December 1, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27905889/influence-of-posterior-corneal-astigmatism-on-postoperative-refractive-astigmatism-in-pseudophakic-eyes-after-cataract-surgery
#5
Maki Sano, Takahiro Hiraoka, Yuta Ueno, Hideo Itagaki, Tomohiro Ogami, Tetsuro Oshika
BACKGROUND: To examine the influence of posterior corneal astigmatism on postoperative refractive astigmatism in pseudophakic eyes after cataract surgery. METHODS: The study enrolled 64 pseudophakic eyes of 50 patients (71.8 ± 9.9 years old, mean ± standard deviation) who had undergone phacoemulsification with non-toric IOL implantation. Refractive astigmatism was measured using an auto ref-keratometer with a 0.01- diopter (D) scale. Two types of corneal astigmatism were calculated using anterior segment optical coherence tomography; keratometric and total corneal astigmatism...
December 1, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27905333/effect-of-cataract-surgery-on-intraocular-pressure-in-supine-and-lateral-decubitus-body-postures
#6
Ji-Hye Park, Chungkwon Yoo, Jong-Suk Song, Shan C Lin, Yong Yeon Kim
PURPOSE: To investigate the effect of phacoemulsification on intraocular pressure (IOP) in different recumbent body postures including supine and lateral decubitus (LD) positions. MATERIALS AND METHODS: This prospective, observational study included patients who had no glaucoma and who had planned to undergo phacoemulsification and intraocular lens implantation in one eye. Before and 1 month after cataract surgery, IOP was measured in both eyes using the Tono-Pen AVIA...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27904835/a-novel-dominant-d109a-cryab-mutation-in-a-family-with-myofibrillar-myopathy-affects-%C3%AE-b-crystallin-structure
#7
Jakub P Fichna, Anna Potulska-Chromik, Przemysław Miszta, Maria Jolanta Redowicz, Anna M Kaminska, Cezary Zekanowski, Sławomir Filipek
Myofibrillar myopathy (MFM) is a group of inherited muscular disorders characterized by myofibrils dissolution and abnormal accumulation of degradation products. So far causative mutations have been identified in nine genes encoding Z-disk proteins, including αB-crystallin (CRYAB), a small heat shock protein (also called HSPB5). Here, we report a case study of a 63-year-old Polish female with a progressive lower limb weakness and muscle biopsy suggesting a myofibrillar myopathy, and extra-muscular multisystemic involvement, including cataract and cardiomiopathy...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/27903086/the-association-of-smokeless-tobacco-use-and-pack-years-of-smokeless-tobacco-with-age-related-macular-degeneration-in-indian-population
#8
Sangeetha Srinvasan, Gayathri Swaminathan, Vaitheeswaran Kulothungan, Tarun Sharma, Rajiv Raman
PURPOSE: To explore the association of use and the influence of pack-year use of smokeless tobacco versus no use with that of early and late age-related macular degeneration (AMD) in rural and urban south Indian population. We hypothesized that the use and pack-years of use would be significantly associated with both early and late AMD. We therefore sought to examine subjects who gave a history of using smokeless tobacco and we quantified the usage as pack-years, to examine the association with that of early and late AMD...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27902443/association-between-cataract-and-risk-of-incident-atrial-fibrillation-a-nationwide-population-based-retrospective-cohort-study
#9
Wei-Syun Hu, Cheng-Li Lin
OBJECTIVE: To identify the association between cataract and the subsequent atrial fibrillation (AF) risk. PATIENTS AND METHODS: Our retrospective cohort study was designed to analyze the Longitudinal Health Insurance Database 2000 of the Taiwan National Health Insurance program. We established a cataract cohort (n=39,347) and a noncataract cohort (n=39,347) to observe the incidence of AF. The cataract cohort included patients who were newly diagnosed with cataract from January 1, 2000, to December 31, 2010...
October 27, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27900449/erratum-to-exome-sequencing-identifies-a-novel-mutation-in-gja8-associated-with-inherited-cataract-in-a-chinese-family
#10
Mei Ren, Xin Guang Yang, Xiao Jie Dang, Jin An Xiao
No abstract text is available yet for this article.
November 29, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27899314/preeclampsia-and-the-risk-of-cataract-extraction-in-life
#11
Nathalie Auger, Marc-André Rhéaume, Gilles Paradis, Jessica Healy-Profitós, Ada Hsieh, William D Fraser
BACKGROUND: Pregnancy-related risk factors for cataract are understudied, including the possibility that preeclampsia increases the risk of cataract later in life. OBJECTIVE: To evaluate the long term risk of cataract extraction following a preeclamptic pregnancy STUDY DESIGN: We carried out a historic cohort study of 1,108,541 women who delivered at least one infant in any hospital in the province of Quebec, Canada between 1989 and 2013, including 64,350 with preeclampsia and 5,732 with cataract extractions...
November 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27899093/microbiological-profile-of-corneal-ulcer-cases-diagnosed-in-a-tertiary-care-ophthalmological-institute-in-nepal
#12
Sharmila Suwal, Dinesh Bhandari, Pratigya Thapa, Mohan Krishna Shrestha, Jyoti Amatya
BACKGROUND: Corneal ulcer, a major cause of monocular blindness in developing countries has consistently been listed as the major cause of blindness and visual disability in many of the developing nations in Asia, Africa and the Middle East, ranking second only to cataract. This study was carried out to determine the microbiological profile of corneal ulcer cases diagnosed among patients visiting Tilganga Institute of Ophthalmology (TIO), Nepal. METHODS: A total of 101 corneal scrapping samples were tested for routine culture and antibiotic susceptibility at the pathology department of TIO Nepal from April to October 2014...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27899085/oestradiol-levels-and-superoxide-dismutase-activity-in-age-related-cataract-a-case-control-study
#13
Dragana Škiljić, Staffan Nilsson, Anne Petersen, Jan-Olof Karlsson, Anders Behndig, Lada Kalaboukhova, Madeleine Zetterberg
BACKGROUND: It has been suggested that the higher prevalence of cataract in women is caused by a withdrawal effect of oestrogen at menopause. In vitro studies have demonstrated protection of serum oestradiol (E2) against oxidative stress through upregulation of antioxidant enzymes, including superoxide dismutase (SOD). The purpose of the present study was to investigate E2 levels and SOD erythrocyte activity in patients with age-related cataract. METHODS: The studied subjects consisted of 103 patients with age-related cataract and 22 controls...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27899084/clinical-outcomes-of-a-new-diffractive-trifocal-intraocular-lens-with-enhanced-depth-of-focus-edof
#14
Banu Torun Acar, Erkan Duman, Saban Simsek
BACKGROUND: To evaluate the clinical outcomes after the implantation of a new trifocal diffractive intraocular lens (IOL) combined with Enhanced depth of focus (EDOF) technology. METHODS: The study enrolled 80 eyes of 40 patients who underwent cataract surgery with bilateral implantation of a diffractive trifocal IOL (Reviol Tri-ED) designed with a combination of enhanced depth of focus. Mean age was 52.09 ± 11.32 years (range from 45 to 70 years). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA), corrected intermediate visual acuity (CIVA), uncorrected near visual acuity (UNVA), corrected near visual acuity (CNVA), keratometry (K), and manifest refraction spherical equivalent (MRSE) were evaluated pre- and postoperatively...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27898986/congenital-cataracts-classification-and-association-with-anterior-segment-abnormalities
#15
Manuel B Datiles, J Fielding Hejtmancik
No abstract text is available yet for this article.
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27898985/a-novel-congenital-cataract-category-system-based-on-lens-opacity-locations-and-relevant-anterior-segment-characteristics
#16
Haotian Lin, Duoru Lin, Zhenzhen Liu, Erping Long, Xiaohang Wu, Qianzhong Cao, Jingjing Chen, Zhuoling Lin, Xiaoyan Li, Li Zhang, Hui Chen, Xiayin Zhang, Jing Li, Weirong Chen, Yizhi Liu
Purpose: We compared the anterior segment characteristics of congenital cataract (CC) patients with lens opacities in different locations and proposed a modified, simple CC category system. Methods: Cataractous eyes of CC patients were classified into four groups based on the locations of lens opacities shown in slit-lamp examinations and by a 3-dimensional anterior segment imaging system as follows: total, anterior, interior, and posterior cataracts. The mean keratometry value, corneal astigmatism (CA), central corneal thickness (CCT), and anterior chamber depth (ACD) of eyes in different groups were compared...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27898468/update-on-ciliary-body-laser-procedures
#17
Behzad Amoozgar, Eileen N Phan, Shan C Lin, Ying Han
PURPOSE OF REVIEW: There are currently various options available for glaucoma treatment procedures ranging from laser to penetrating to nonpenetrating surgeries. Innovations in glaucoma surgical therapeutics include features such as external application, focused tissue effects, and minimal manipulation as these factors all help lower the risk of side-effects in addition to increasing the success rate of the treatment. Traditional diode laser transscleral cyclophotocoagulation (TSCPC) is invasive and destructive...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27898467/an-update-on-therapeutic-modalities-for-the-prevention-of-angle-closure-glaucoma
#18
Behzad Amoozgar, Sasan Moghimi, Ying Han, Shan C Lin
PURPOSE OF REVIEW: Angle closure glaucoma is a prominent burden for the worldwide health system. Because this disorder is commonly asymptomatic, and can lead to irreversible blindness, the proper screening and early management of this disease can be critical. The definitions of angle closure and consequently its treatment guidelines have been dynamically modified and updated in the past decades. Surgical and laser techniques have been adapted to address the different mechanisms involved in the manifestation of the disease and properly prevent its progression in different stages...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27898449/modern-phacoemulsification-and-intraocular-lens-implantation-refractive-lens-exchange-is-safe-and-effective-in-treating-high-myopia
#19
Bhaskar Srinivasan, Hiu Ying Leung, He Cao, Shu Liu, Lizhen Chen, Alex Hoi Fan
Improved efficacy, predictability, and safety of modern phacoemulsification have resulted in cataract surgery being considered as a refractive procedure. Refractive lens exchange by definition is a surgery aimed at replacing the cataractous or clear crystalline lens with an intraocular lens (IOL) in cases of high ametropia. The excellent intraocular optics of this procedure provide a better visual outcome as compared with laser refractive surgery in high myopia. With advances in technology and IOL formulas, the predictability of refractive outcome after cataract surgery in high myopes has improved...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898441/epidemiology-of-myopia
#20
Pei-Chang Wu, Hsiu-Mei Huang, Hun-Ju Yu, Po-Chiung Fang, Chueh-Tan Chen
Myopia is not a simple refractive error, but an eyesight-threatening disease. There is a high prevalence of myopia, 80% to 90%, in young adults in East Asia; myopia has become the leading cause of blindness in this area. As the myopic population increases globally, the severity of its impact is predicted. Approximately one fifth of the myopic population has high myopia (≥-6 diopters), which results in irreversible vision loss such as retinal detachment, choroidal neovascularization, cataracts, glaucoma, and macular atrophy...
November 2016: Asia-Pacific Journal of Ophthalmology
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