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Julie Bonigen, Christine Raynaud-Donzel, José Hureaux, Nora Kramkimel, Astrid Blom, Géraldine Jeudy, Anne-Laure Breton, Thomas Hubiche, Christophe Bedane, Delphine Legoupil, Anne Pham-Ledard, Julie Charles, Maurice Pérol, Emilie Gérard, Patrick Combemale, Daphné Bonnet, Michèle-Léa Sigal, Emmanuel Mahé
Nivolumab (Opdivo(®) ), pembrolizumab (Keytruda(®) ), atezolizumab, and pidilizumabab are anti-PD1 monoclonal antibodies. Nivolumab is licensed in advanced melanoma and second-line therapy of advanced or metastatic non-small cell lung cancer. When activated, the programmed cell death (PD)-1 is implicated in the inhibition of the immune system. Anti-PD1 removes this inhibition and allows the immune system to control tumour cell progression.(1-4) Immune-mediated toxicity of this treatment have been reported, either organ-specific toxicities - i...
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Charles Khouri, Marion Lepelley, Céline Villier, Thierry Bougerol, Michel Mallaret
PURPOSE: Cyamemazine (Tercian(®)) is currently the most widely prescribed neuroleptic in France. This widespread use is due to its anxiolytics properties and to a claimed good safety profile. Although, prescription of cyamemazine is not devoid of the risks associated with the use of neuroleptics: extrapyramidal syndromes. This study aims at describing extrapyramidal syndromes induced by cyamemazine registered in the French pharmacovigilance database. METHODS: All spontaneous reports of extrapyramidal syndromes in the French pharmacovigilance database between 1st January 1985 and 31th December 2015 were described and analyzed...
September 15, 2016: Thérapie
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Intellectual and Developmental Disabilities
Natalia Del Campo, Matteo Cesari, Marco Canevelli, Emiel O Hoogendijk, Matthieu Lilamand, Eirini Kelaiditi, Maria E Soto, Pierre-Jean Ousset, Michael W Weiner, Sandrine Andrieu, Bruno Vellas
OBJECTIVES: Recent evidence suggests that a substantial minority of people clinically diagnosed with probable Alzheimer disease (AD) in fact do not fulfill the neuropathological criteria for the disease. A clinical hallmark of these phenocopies of AD is that these individuals tend to remain cognitively stable for extended periods of time, in contrast to their peers with confirmed AD who show a progressive decline. We aimed to examine the prevalence of patients clinically diagnosed with mild-to-moderate AD who do not experience the expected clinically significant cognitive decline and identify markers easily available in routine medical practice predictive of a stable cognitive prognosis in this population...
October 1, 2016: Journal of the American Medical Directors Association
L Bardiaux, S Vauzou, B Olivier, D Mathieu-Daude, E Durand, C Dite, F Roubinet
During 3 months, platelet concentrates prepared by "Établissement français du sang Pyrénées-Méditerranée" (Blood bank) were treated with the Intercept process (CERUS(©)). This study primarily aimed to measure the organizational impact of this technology on transfusion chain. The introduction of Intercept did not raise any major difficulties, but required some adaptations upstream from the deployment. Prior information of health care institutions and physician was essential to anticipate the practical changes, including the prescription of platelet concentrates (CMV negative, irradiation)...
September 16, 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
G Daurat
Computer assisted prescription of labile blood products is just at its beginning. Current programs already allow embedding automatically such data as patient's and prescribers' identification or ward details to produce readable prescriptions, also complying with part of Good Practice guidelines. Now prescriptions can also be sent electronically to the Etablissement Francais du Sang, the French blood products services. Usually they are computer programs specialised in transfusion and interfaced with the main patient's file software...
September 14, 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
(no author information available yet)
No abstract text is available yet for this article.
September 2016: American Journal on Intellectual and Developmental Disabilities
L Le Normand, M Cosson, F Cour, X Deffieux, L Donon, P Ferry, B Fatton, J-F Hermieu, H Marret, G Meurette, A Cortesse, L Wagner, X Fritel
OBJECTIVE: Providing clinical practice guidelines for first surgical treatment of female pelvic organ prolapse. METHODS: Systematic literature review, level of evidence rating, external proofreading, and grading of recommendations by 5 French academic societies: Association française d'urologie, Collège national des gynécologues et obstétriciens français, Société interdisciplinaire d'urodynamique et de pelvi-périnéologie, Société nationale française de coloproctologie, and Société de chirurgie gynécologique et pelvienne...
July 2016: Progrès en Urologie
Howard Berger, Robert Gagnon, Mathew Sermer, Melanie Basso, Hayley Bos, Richard N Brown, Emmanuel Bujold, Stephanie L Cooper, Robert Gagnon, Katy Gouin, N Lynne McLeod, Savas M Menticoglou, William R Mundle, Anne Roggensack, Frank L Sanderson, Jennifer D Walsh
OBJECTIF: La présente Directive passe en revue les données probantes liées au diagnostic et à la prise en charge obstétricale du diabète durant la grossesse. ISSUES: Les issues évaluées étaient les issues maternelles à court et à long terme, dont la prééclampsie, la césarienne, le diabète éventuel et d'autres complications cardiovasculaires et les issues fœtales, dont les anomalies congénitales, la mortinaissance, la macrosomie, le traumatisme de la naissance, l'hypoglycémie et les effets à long terme...
July 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Marie-Amelie de Menorval, Franck M Andre, Aude Silve, Claire Dalmay, Olivier Français, Bruno Le Pioufle, Lluis M Mir
Human adipose mesenchymal stem cells (haMSCs) are multipotent adult stem cells of great interest in regenerative medicine or oncology. They present spontaneous calcium oscillations related to cell cycle progression or differentiation but the correlation between these events is still unclear. Indeed, it is difficult to mimic haMSCs spontaneous calcium oscillations with chemical means. Pulsed electric fields (PEFs) can permeabilise plasma and/or organelles membranes depending on the applied pulses and therefore generate cytosolic calcium peaks by recruiting calcium from the external medium or from internal stores...
2016: Scientific Reports
J J Stirnemann, N Fries, R Bessis, M Fontanges, R Mangione, L J Salomon
OBJECTIVE: To assess potential differences in fetal size between the French population and the international population from the INTERGROWTH-21(st) (IG) project and to measure the impact of switching to the IG references for fetal size. DESIGN AND SETTING: Nationwide cross-sectional study of fetal ultrasound biometry. POPULATION: Low-risk pregnancies prospectively recruited within the network of the national French college of fetal ultrasound over a 6 week-period...
August 12, 2016: Ultrasound in Obstetrics & Gynecology
(no author information available yet)
No abstract text is available yet for this article.
August 2016: Intellectual and Developmental Disabilities
(no author information available yet)
No abstract text is available yet for this article.
July 2016: American Journal on Intellectual and Developmental Disabilities
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Intellectual and Developmental Disabilities
Anne Batisse, Hélène Peyrière, Céline Eiden, Marie-Anne Courné, Samira Djezzar
The "SLAM" phenomenon is an increasingly popular practice, in Paris and London gay scene, defined by 3 characteristics: injection, sexual party and psychostimulant drugs. The French Medical Agency requested a risk assessment of "SLAM" and more broadly of the use of psychostimulants in a sexual context, by the analysis of complications related to this practice notified to the French Network of Addictovigilance Centers. All cases of complications related to "SLAM" practice, including cases of abuse or dependence, and somatic and psychiatric complications, were analysed...
April 26, 2016: Thérapie
Mrinal M Patnaik, Ayalew Tefferi
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder characterized by overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Diagnosis is based on the presence of persistent (>3 months) peripheral blood monocytosis (>1 × 10(9) /L), along with bone marrow dysplasia. Clonal cytogenetic abnormalities occur in ∼20-30% of patients, while >90% have gene mutations. Mutations involving TET2 (∼60%), SRSF2 (∼50%), ASXL1 (∼40%), and RAS (∼30%) are frequent; with only ASXL1 mutations negatively impacting overall survival...
June 2016: American Journal of Hematology
Alexis Régent, Serge Redeker, Alban Deroux, Pierre Kieffer, Kim Heang Ly, Maxime Dougados, Eric Liozon, Claire Larroche, Loïc Guillevin, Laurence Bouillet, Olivier Espitia, Nathalie Costedoat-Chalumeau, Martin Soubrier, Benoît Brihaye, François Lifermann, Guillaume Lefevre, Xavier Puéchal, Luc Mouthon, Eric Toussirot
OBJECTIVE: To report the efficacy and safety of tocilizumab (TCZ) for giant cell arteritis (GCA). METHODS: A retrospective multicenter study that included 34 patients receiving TCZ for GCA. RESULTS: TCZ was effective in all but 6 patients, who still had mild symptoms. Mean glucocorticoid dose was tapered. One patient died and 3 patients had to stop TCZ therapy because of severe adverse events. Twenty-three patients stopped treatment; 8 of these experienced relapses after a mean of 3...
August 2016: Journal of Rheumatology
Jean-Luc Brun, Olivier Graesslin, Arnaud Fauconnier, Renaud Verdon, Aubert Agostini, Antoine Bourret, Emilie Derniaux, Olivier Garbin, Cyrille Huchon, Catherine Lamy, Roland Quentin, Philippe Judlin
BACKGROUND: Pelvic inflammatory disease (PID) is commonly encountered in clinical practice. OBJECTIVES: To provide up-to-date guidelines on management of PID. SEARCH STRATEGY: An initial search of the Cochrane database, PubMed, and Embase was performed using keywords related to PID to identify reports in any language published between January 1990 and January 2012, with an update in May 2015. SELECTION CRITERIA: All identified reports relevant to the areas of focus were included...
August 2016: International Journal of Gynaecology and Obstetrics
(no author information available yet)
No abstract text is available yet for this article.
May 2016: American Journal on Intellectual and Developmental Disabilities
S Patoux, L Istasse
Eight trained horses (6 mares - 2 geldings, 6 Selle Français, 2 Trotteur Français, 12 ± 5.8 years old, 538 ± 72.5 kg) were offered three diets to potentially affect haematology and the fatty acids (FA) profiles in red blood cells (RBC) membranes. The control diet was composed of 50% hay and 50% concentrate containing mainly rolled barley (48%) and whole spelt (48%). In the case of sunflower oil diet, sunflower oil (62.0% of α-linoleic acid, LA) was incorporated at a rate of 8% and substituted by an equal proportion of barley...
October 2016: Journal of Animal Physiology and Animal Nutrition
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