Read by QxMD icon Read


Mrinal M Patnaik, Ayalew Tefferi
DISEASE OVERVIEW: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms, with an inherent risk for leukemic transformation (∼15%-20% over 3-5 years). DIAGNOSIS: Diagnosis is based on the presence of sustained (>3 months) peripheral blood monocytosis (≥1 × 109 /L; monocytes ≥10%), along with bone marrow dysplasia. Clonal cytogenetic abnormalities occur in ∼ 30% of patients, while >90% have gene mutations...
June 2018: American Journal of Hematology
Sakina Bensalem, Filipa Lopes, Pierre Bodénès, Dominique Pareau, Olivier Français, Bruno Le Pioufle
Data are related to Confocal Laser Scanning Microscopy (CLSM) observations of lipid-enriched Chlamydomonas reinhardtii cells under different conditions. Firstly, the impact of stress conditions (nitrogen starvation) on the cell wall structure is assessed. Secondly is described the effect of solvents, in the context of lipid extraction, on the microalga's cell, particularly its lipid droplets, in the perspective of understanding the mechanisms behind solvent extraction of lipids. Furthermore, the role of the cell wall as a barrier to the solvent extraction action is highlighted...
April 2018: Data in Brief
Benjamin Wolff, Vivien Vasseur, Armelle Cahuzac, Florence Coscas, Laurent Castelnovo, Catherine Favard, Guillaume Michel, Catherine Français, Laurence Salomon, Martine Mauget-Faÿsse
INTRODUCTION: Polypoidal choroidal vasculopathy (PCV) is a choroidal pathology characterized by frequent occurrences of subretinal hemorrhages and resistance to monotherapies such as ranibizumab or bevacizumab intravitreal injections (IVT). The purpose of this study is to evaluate both the anatomical and functional efficacy of aflibercept IVT as a monotherapy in PCV in a Caucasian population. METHODS: We conducted a prospective multicenter study in either treatment-naïve patients with PCV or PVC patients who had not been treated with anti-VEGF within the previous 3 months or with photodynamic therapy (PDT) within the previous 6 months...
May 25, 2018: Ophthalmologica. Journal International D'ophtalmologie
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Intellectual and Developmental Disabilities
Michaël Rochoy, Christina Zakhem-Stachera, Johana Béné, Christophe Berkhout, Sophie Gautier
OBJECTIVE: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. METHODS: Retrospective study of such cases/non-cases from observations recorded in the French national pharmacovigilance between 01/01/2004 and 31/12/2013. We studied all antidepressants marketed in 2014 in France, with a positive control (haloperidol) and a negative one (amoxicillin)...
March 1, 2018: Thérapie
Marie Brionne-François, Anne Bauters, Christine Mouton, Sophie Voisin, Claire Flaujac, Agnès Le Querrec, Dominique Lasne
Point of care testing (POCT) must comply with regulatory requirements according to standard EN ISO 22870, which identify biologists as responsible for POCT. INR for vitamin K antagonists (VKAs) monitoring is a test frequently performed in haemostasis laboratories. Bedside INR is useful in emergency room, in particular in case of VKAs overdosage but also for specific populations of patients like paediatrics or geriatrics. INR POCT devices are widely used at home by the patients for self-testing, but their use in the hospital by the clinical staff for bedside measurement is growing, with devices which now comply with standard for POCT accreditation for hospital use...
April 27, 2018: Annales de Biologie Clinique
Salem Hannoun, Damien Heidelberg, Roula Hourani, Thi Thuy Trang Nguyen, Jean-Christophe Brisset, Sylvie Grand, Stéphane Kremer, Fabrice Bonneville, Charles R G Guttmann, Vincent Dousset, François Cotton
BACKGROUND AND PURPOSE: The aim of this prospective study is to investigate and evaluate in clinical practice the diagnostic impact of 3DFLAIR in regards to 2DT2/PD in terms of infratentorial lesions detection in multiple sclerosis (MS). MATERIAL AND METHODS: 164 MS patients from the OFSEP database were reviewed retrospectively. MR examinations were performed on 1.5T or 3T systems from four different centers. Infratentorial lesions were counted and allocated to different regions of the posterior fossa by three raters independently (junior resident, resident with an expertise in neuroradiology, and senior neuro-radiologist) on the 3DFLAIR and 2DT2/PD...
May 2018: European Journal of Radiology
(no author information available yet)
No abstract text is available yet for this article.
May 2018: American Journal on Intellectual and Developmental Disabilities
M Rochoy, R Thomas, J Béné, D Deleplanque, M-C Vantyghem, S Gautier, D Deplanque
INTRODUCTION: Age-related androgenic deficiency (DALA) is a pathology that is increasingly cited in recent publications. The cardiovascular risk of testosterone is debated: present for the FDA, absent for the European Medicines Agency in 2015. Our objective was to analyze the association between androgens and vascular pathologies in adverse reactions reported in pharmacovigilance databases. MATERIAL AND METHOD: We conducted a retrospective case series study of the French and Canadian pharmacovigilance databases for the period 2005-2015...
May 2018: Progrès en Urologie
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Intellectual and Developmental Disabilities
Sakina Bensalem, Filipa Lopes, Pierre Bodénès, Dominique Pareau, Olivier Français, Bruno Le Pioufle
One way envisioned to overcome part of the issues biodiesel production encounters today is to develop a simple, economically viable and eco-friendly process for the extraction of lipids from microalgae. This study investigates the lipid extraction efficiency from the microalga Chlamydomonas reinhardtii as well as the underlying mechanisms. We propose a new methodology combining a pulsed electric field (PEF) application and mechanical stresses as a pretreatment to improve lipid extraction with solvents. Cells enriched in lipids are therefore submitted to electric field pulses creating pores on the cell membrane and then subjected to a mechanical stress by applying cyclic pressures on the cell wall (using a microfluidic device)...
June 2018: Bioresource Technology
I Chanavaz-Lacheray, E Darai, P Descamps, A Agostini, M Poilblanc, P Rousset, P-A Bolze, P Panel, P Collinet, T Hebert, O Graesslin, H Martigny, J-L Brun, H Dechaud, C Mezan De Malartic, L Piechon, A Wattiez, C Chapron, F Golfier
OBJECTIVES: The Collège national des gynécologues obstétriciens français (CNGOF), in agreement with the Société de chirurgie gynécologique et pelvienne (SCGP), has set up a commission in 2017 to define endometriosis expert centres, with the aim of optimizing endometriosis care in France. METHODS: The committee included members from university and general hospitals as well as private facilities, representing medical, surgical and radiological aspects of endometriosis care...
March 2018: Gynecologie, Obstetrique, Fertilite & Senologie
(no author information available yet)
No abstract text is available yet for this article.
March 2018: American Journal on Intellectual and Developmental Disabilities
Teresa Maria Antonini, Olivier Guillaud, Jérôme Dumortier, Sébastien Dharancy, Faouzi Saliba, Philippe Mathurin, Jean-Charles Duclos-Vallée, Christophe Duvoux
No abstract text is available yet for this article.
February 24, 2018: Liver Transplantation
Alessandro Mirra, Micaël David Klopfenstein Bregger, Olivier Louis Levionnois
A 15-year-old Selle Francais gelding was presented to the equine referral hospital for treatment of a left guttural pouch mycosis previously diagnosed. After induction, the horse was shortly hoisted by all four feet, moved on a padded surgical table, and positioned in right lateral recumbency. In order to reduce the risk of bleeding during surgical manipulation of the carotid and maxillary arteries, a mean arterial pressure between 60 and 70 mmHg was targeted. After surgery, the horse was moved in a padded recovery box keeping the same lateral recumbency...
2018: Frontiers in Veterinary Science
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Intellectual and Developmental Disabilities
E Touzé, Y Gruel, I Gouin-Thibault, E De Maistre, S Susen, P Sie, L Derex
BACKGROUND AND PURPOSE: Whereas intravenous thrombolysis (IVT) is allowed for acute ischaemic stroke in patients on vitamin K antagonists with international normalized ratio ≤1.7, there are no similar recommendations for patients on direct oral anticoagulants (DOACs), notably due to the lack of coagulation tests to assess the therapeutic effects. Although the literature is scarce, consisting of small case series and retrospective studies, considering the frequency of this situation the French Vascular Neurology Society and the French Study Group on Haemostasis and Thrombosis have worked on a joint position paper to provide a practical position regarding the emergency management of ischaemic stroke in patients on DOACs...
May 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Salvatore Mastrangelo, Filippo Biscarini, Barbara Auzino, Marco Ragatzu, Andrea Spaterna, Roberta Ciampolini
OBJECTIVE: Braque Français, type Pyrénées is a French hunting-dog breed whose origin is traced back to old pointing gun-dogs used to assist hunters in finding and retrieving game. This breed is popular in France, but seldom seen elsewhere. Despite the ancient background, the literature on its genetic characterization is surprisingly scarce. A recent study looked into the demography and inbreeding using pedigree records, but there is yet no report on the use of molecular markers in this breed...
January 9, 2018: BMC Research Notes
(no author information available yet)
No abstract text is available yet for this article.
January 2018: American Journal on Intellectual and Developmental Disabilities
Philip D Perkins
The Madagascar fauna of the beetle family Hydraenidae is comprehensively revised, based on the study and databasing of 6,949 specimens. New collection records are provided for 11 previously described species, and 95 new species are described. Three new subgenera of Hydraena, viz. H. (Micromadraena), H. (Monomadraena), and H. (Dnahydnaedna) are described, and several new species groups of Hydraena are diagnosed. Two new genera in the tribe Madagastrini are described: Menomadraena and Trinomadraena. The Malagasy hydraenid fauna now comprises 106 species arrayed in the following nine genera: Aulacochthebius (2), Hydraena (65), Limnebius (10), Madagaster (8), Menomadraena (6), Ochthebius (1), Protozantaena (5), Sicilicula (8), and Trinomadraena (1)...
November 3, 2017: Zootaxa
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"