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https://www.readbyqxmd.com/read/28285516/investigation-on-key-molecules-of-hlb-induced-orange-juice-off-flavor
#1
Johannes Kiefl, Birgit Kohlenberg, Anja Hartmann, Katja Obst, Susanne Paetz, Gerhard E Krammer, Stephan Trautzsch
Orange fruits from Huanglongbing (HLB) infected trees do not fully mature and show a severe off-flavor described as bitter-harsh, metallic and less juicy and fruity. The investigation of juice from HLB infected (HLBOJ) and healthy control oranges (COJ) by gas chromatography mass spectrometry showed higher concentrations of fruity esters such as ethyl butyrate and ethyl 2-methylbutyrate, and soapy-waxy alkanals such as octanal and decanal in the COJ whereas the HLBOJ showed higher concentrations of green aldehydes like hexanal and degradation compounds of limonene and linalool like α-terpineol...
March 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28263849/chemical-profiles-and-pharmacological-activities-of-chang-kang-fang-a-multi-herb-chinese-medicinal-formula-for-treating-irritable-bowel-syndrome
#2
Qian Mao, Lei Shi, Zhi-Gang Wang, Yu-Hui Luo, Yin-Yu Wang, Xue Li, Min Lu, Jian-Min Ju, Jin-Di Xu, Ming Kong, Shan-Shan Zhou, Min-Qin Shen, Song-Lin Li
ETHNOPHARMACOLOGICAL RELEVANCE: Chang-Kang-Fang formula (CKF), a multi-herb traditional Chinese medicinal formula, has been clinically used for treatment of irritable bowel syndrome (IBS). The mechanisms of CKF for treating IBS and the components that are responsible for the activities were still unknown. AIM OF THE STUDY: To investigate the chemical profiles and effects of CKF on IBS model. MATERIALS AND METHODS: The chemical profiles of CKF were investigated by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q/TOF-MS/MS)...
March 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28251024/petroselinum-crispum-is-effective-in-reducing-stress-induced-gastric-oxidative-damage
#3
Ayşin Akıncı, Mukaddes Eşrefoğlu, Elif Taşlıdere, Burhan Ateş
BACKGROUND: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury. Parsley (Petroselinum crispum) contains many antioxidants such as flavanoids, carotenoids and ascorbic acid. AIMS: In this study, the histopathological and biochemical results of nutrition with a parsley-rich diet in terms of eliminating stress-induced oxidative gastric injury were evaluated. STUDY DESIGN: Animal experimentation...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28211296/recommendations-for-the-medical-management-of-chronic-venous-disease-the-role-of-micronized-purified-flavanoid-fraction-mpff
#4
Ronald Bush, Anthony Comerota, Mark Meissner, Joseph D Raffetto, Steven R Hahn, Katherine Freeman
Scope A systematic review of the clinical literature concerning medical management of chronic venous disease with the venoactive therapy Micronized Purified Flavonoid Fraction was conducted in addition to an investigation of the hemodynamics and mechanism of chronic venous disease. Methods The systematic review of the literature focused on the use of Micronized Purified Flavonoid Fraction (diosmin) which has recently become available in the US, in the management of chronic venous disease. The primary goal was to assess the level of evidence of the role of Micronized Purified Flavonoid Fraction in the healing of ulcers, and secondarily on the improvement of the symptoms of chronic venous disease such as edema...
April 2017: Phlebology
https://www.readbyqxmd.com/read/28192456/the-flavanone-homoeriodictyol-increases-sglt-1-mediated-glucose-uptake-but-decreases-serotonin-release-in-differentiated-caco-2-cells
#5
Barbara Lieder, Julia Katharina Hoi, Ann-Katrin Holik, Katrin Geissler, Joachim Hans, Barbara Friedl, Kathrin Liszt, Gerhard E Krammer, Jakob P Ley, Veronika Somoza
Flavanoids and related polyphenols, among them hesperitin, have been shown to modulate cellular glucose transport by targeting SGLT-1 and GLUT-2 transport proteins. We aimed to investigate whether homoeriodictyol, which is structurally related to hesperitin, affects glucose uptake in differentiated Caco-2 cells as a model for the intestinal barrier. The results revealed that, in contrast to other polyphenols, the flavanon homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM...
2017: PloS One
https://www.readbyqxmd.com/read/28038426/oxidized-epigallocatechin-gallate-inhibited-lysozyme-fibrillation-more-strongly-than-the-native-form
#6
Ting-Ting An, Shuang Feng, Cheng-Ming Zeng
Epigallocatechin gallate (EGCG), the most abundant flavanoid in green tea, is currently being evaluated in the clinic due to its benefits in the treatment of amyloid disorders. Its anti-amyloidogenic effect has been attributed to direct interaction of the intact molecule with misfolded polypeptides. In addition, antioxidant activity is also involved in the anti-amyloidogenic role. The detailed molecular mechanism is still unclear and requires further investigation. In the present study, the kinetics of EGCG oxidation and the anti-amyloidogenic effect of the resultant oxidation substances have been examined...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28035685/a-medicinal-herb-cassia-alata-attenuates-quorum-sensing-in-chromobacterium-violaceum-and-pseudomonas-aeruginosa
#7
P D Rekha, H S Vasavi, C Vipin, K Saptami, A B Arun
Quorum sensing (QS) has been shown to play a crucial role in the pathogenesis in many bacteria and attenuation of QS is one of the targets of antimicrobial therapy with particular interest in combating drug resistance. This study reports the QS inhibitory activity of metabolites from Cassia alata L. (Ca. alata), an important medicinal herb widely used in the treatment of microbial infections. For investigating the QS inhibition (QSI) potential of Ca. alata L., initially, metabolites of the leaves extracted using ethanol were tested against biosensor strain Chromobacterium violaceum CV026 and C...
December 30, 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28000096/relationship-between-tissue-distributions-of-modified-wuzi-yanzong-prescription-in-rats-and-meridian-tropism-theory
#8
Lin-Lin Wang, Wei-Wei Li, Cai-Sheng Wu, Jin-Lan Zhang, Yi-Xiang Song, Fang-Jiao Song, Hong Fu, Geng-Xin Liu, Xue-Mei Wang
OBJECTIVE: To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription (, MWP) in rats and meridian tropism theory. METHODS: A high-performance liquid chromatography with Fourier transform-mass spectrometry (HPLC-FT) method was used to identify the metabolites of MWP in different tissues of rats after continued oral administration of MWP for 7 days. The relationship between MWP and meridian tropism theory was studied according to the tissue distributions of the metabolites of MWP in rats and the relevant literature...
December 20, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27903990/baicalein-reduces-angiogenesis-in-the-inflammatory-microenvironment-via-inhibiting-the-expression-of-ap-1
#9
Yujie Huang, Zhaorui Miao, Yang Hu, Yang Yuan, Yuxin Zhou, Libin Wei, Kai Zhao, Qinglong Guo, Na Lu
Increasing clinical and experimental studies have demonstrated that refractory chronic inflammation will result in malignant tumor and anti-angiogenic therapy may be an effective way to thwart the progression. Baicalein, one of the major active flavanoids found in Scutellaria baicalensis Georgi, has been exhibited potent anti-inflammation and anti-tumor effects by reducing angiogenesis. However, the exact mechanism of baicalein on endothelial cells in inflammatory microenvironment was not clear yet. Here, we investigated the anti-angiogenic effect of baicalein by incubating human umbilical vein endothelial cells (HUVECs) with THP-1 conditioned medium in vitro...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27815688/effect-of-gestational-intake-of-fisetin-3-3-4-7-tetrahydroxyflavone-on-developmental-methyl-mercury-neurotoxicity-in-f1-generation-rats
#10
Sherin Jacob, Sumathi Thangarajan
Methyl mercury (MeHg) is a developmental neurotoxin that causes irreversible cognitive damage in offspring of gestationally exposed mothers. Currently, no preventive drugs are established against MeHg developmental neurotoxicity. The neuroprotective effect of gestational administration of a flavanoid against in utero toxicity of MeHg is not explored much. Hence, the present study validated the effect of a bioactive flavanoid, fisetin, on MeHg developmental neurotoxicity outcomes in rat offspring at postnatal weaning age...
November 4, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27576736/filaricidal-activities-on-onchocerca-ochengi-and-loa-loa-toxicity-and-phytochemical-screening-of-extracts-of-tragia-benthami-and-piper-umbellatum
#11
Fidelis Cho-Ngwa, Elvis Monya, Boris K Azantsa, Faustin Pascal T Manfo, Smith B Babiaka, James A Mbah, Moses Samje
BACKGROUND: Onchocerciasis is the world's second leading infectious cause of blindness. Its control is currently hampered by the lack of a macrofilaricidal drug and by severe adverse events observed when the lone recommended microfilaricide, ivermectin is administered to individuals co-infected with Loa loa. Therefore, there is the need for a safe and effective macrofilaricidal drug that will be able to cure the infection and break transmission cycles, or at least, an alternative microfilaricide that does not kill L...
August 30, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27544550/diosmin-induce-apoptosis-through-modulation-of-stat-3-signaling-in-7-12-dimethylbenz-a-anthracene-induced-harmster-buccal-pouch-carcinogenesis
#12
Muthusamy Rajasekar, Kathiresan Suresh, Kathiresan Sivakumar
Diosmin is naturally found flavanoid in many citrus fruits known to have anti-inflammatory, antihyperglycemic, antioxidant and antimutagenic properties. Effects of Diosmin on IL-6/STAT-3 expression in hamster buccal pouch carcinogenesis remain unclear. Alterations in many genes encode crucial proteins, which regulate cell proliferation, differentiation and apoptosis have been implicated in oral cancer. In the present study, we investigated the effect of dietary Diosmin on IL-6/STAT-3 signaling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis by examining the protein expression of IL-6/STAT-3 and its related genes...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27428764/potential-antidepressant-like-activity-of-silymarin-in-the-acute-restraint-stress-in-mice-modulation-of-corticosterone-and-oxidative-stress-response-in-cerebral-cortex-and-hippocampus
#13
Vishnu N Thakare, Valmik D Dhakane, Bhoomika M Patel
BACKGROUND: Silymarin is a polyphenolic flavanoid of Silybum marianum, elicited neuroprotection and antidepressant like activity in stressed model. It was found to increase 5-hydroxytryptamine (5-HT) levels in the cortex and dopamine (DA) and norepinephrine (NE) in the cerebellum in normal mice. The aim of the present study was to investigate the potential antidepressant-like activity of silymarin in the acute restraint stress (ARS) in mice. METHODS: The ARS was induced by immobilizing the mice for a period of 7h using rodent restraint device preventing them for any physical movement...
October 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27365992/evaluating-the-anticancer-potential-of-ethanolic-gall-extract-of-terminalia-chebula-gaertn-retz-combretaceae
#14
B E Ravi Shankara, Y L Ramachandra, S Sundara Rajan, P S Sujan Ganapathy, Nagendra Sastry Yarla, S A Richard, Bhadrapura Lakkappa Dhananjaya
UNLABELLED: Plants have been an important source for discovery of anticancer compounds. With the current decline in the number of new molecular entities from the pharmaceutical industry, novel anticancer agents are being sought from traditional medicines; therefore the anticancer efficacy of many plants that are used in traditional medicine is yet to be verified. The objective of the study was to evaluate the cytotoxic potential of ethanolic leaf gall extract of Terminalia chebula are evaluated against buffalo rat liver 3A, MCF-7 (Human mammary gland adenocarcinoma) and A-549 (Human lung cancer) cell lines...
July 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27338088/therapeutic-effects-of-egcg-a-patent-review
#15
REVIEW
Leewanshi Chakrawarti, Rishab Agrawal, Shweta Dang, Sanjay Gupta, Reema Gabrani
INTRODUCTION: Green tea contains polyphenolic flavanoids such as epigallocatechin-3- gallate (EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC) and epicatechin (EC). EGCG is the most abundant and active compound in green tea. Extensive research has shown that it has significant antioxidant, anti-carcinogenic, anti-microbial, and neuroprotective properties and has therapeutic potential against various human diseases. AREAS COVERED: This review focuses on the applications of EGCG alone, and in combination with other compounds, for the treatment of various types of cancers, metabolic, neurodegenerative, and microbial diseases, and discusses its mechanism of action in cell line and animal modesl...
August 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27318603/phenolic-compounds-in-drumstick-peel-for-the-evaluation-of-antibacterial-hemolytic-and-photocatalytic-activities
#16
T V Surendra, Selvaraj Mohana Roopan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Makuteswaran Sridharan
Most of the wastes emitted from the food processing industries are not utilized for any further purpose. The economic value of the food waste is very less when compared to the collection or reuse or discard. To increase the economic value we have to design the food waste as useful product or applicable in most of the current field. Nothing is waste in this world with this concept we have investigated the phytochemical analysis of drumstick peel (Moringa oleifera). The result supports the presence of phenols, alkaloids, flavanoids, glycosides and tannins...
August 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27278109/pharmaceutical-cocrystals-walking-the-talk
#17
Geetha Bolla, Ashwini Nangia
Pharmaceutical cocrystals belong to a sub-class of cocrystals wherein one of the components is a drug molecule (or an active pharmaceutical ingredient, API) and the second is a benign food or drug grade additive (generally regarded as safe, GRAS). The two components are hydrogen-bonded in a fixed stoichiometric ratio in the crystal lattice. In the past decade, pharmaceutical cocrystals have demonstrated significant promise in their ability to modify the physicochemical and pharmacokinetic properties of drug substances, such as the solubility and dissolution rate, bioavailability, particle morphology and size, tableting and compaction, melting point, physical form, biochemical and hydration stability, and permeability...
June 28, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27248833/identification-of-an-anti-inflammatory-potential-of-eriodictyon-angustifolium-compounds-in-human-gingival-fibroblasts
#18
Jessica Walker, Katharina V Reichelt, Katja Obst, Sabine Widder, Joachim Hans, Gerhard E Krammer, Jakob P Ley, Veronika Somoza
Polyphenol-rich plant extracts have been shown to possess anti-inflammatory activity against oral pathogen-induced cytokine release in model systems of inflammation. Here, it was hypothesized that a flavanone-rich extract of E. angustifolium exhibits an anti-inflammatory potential against endotoxin-induced inflammatory response in human gingival fibroblasts (HGF-1). HGF-1 cells were stimulated with lipopolysaccharide from Porphyromonas gingivalis (pg-LPS) to release pro-inflammatory cytokines. Concentrations of interleukins IL-6 and IL-8 and macrophage chemoattractant protein-1 in the incubation media upon stimulation were determined by means of magnetic bead analysis...
July 13, 2016: Food & Function
https://www.readbyqxmd.com/read/27168687/evaluation-of-parmotrema-reticulatum-taylor-for-antibacterial-and-antiinflammatory-activities
#19
A P Jain, S Bhandarkar, G Rai, A K Yadav, S Lodhi
Lichens produce variety of secondary metabolites including depsides, depsidones and dibenzofurans having multifunctional activity in response to external environmental condition. Present study provides evidence for in vitro antibacterial and in vivo antiinflammatory activity of acetone and ethanol extracts of Parmotrema reticulatum. In vitro antibacterial activity was investigated against gram positive and gram negative bacteria. Cotton pellet-induced granuloma, xylene-induced ear swelling, carragennan-induced edema, histamine-induced and carboxymethylcellulose sodium-induced leukocyte emigration in mice models were used to quantify the antiinflammatory activity...
January 2016: Indian Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27109905/fruit-as-potent-natural-antioxidants-and-their-biological-effects
#20
REVIEW
Neuza F Gomes-Rochette, Mirele Da Silveira Vasconcelos, Seyed M Nabavi, Erika F Mota, Diana C S Nunes-Pinheiro, Maria Daglia, Dirce F De Melo
The consumption of fruit has increased in the last 20 years, along with the growing recognition of its nutritional and protective values. Many of the benefits of a diet rich in fruit are attributed to the presence of different bioactive substances, such as vitamins, carotenoids and phenolic compounds. Flavanoids, a class of phenolic compounds, present particular antioxidant activity and thus provide protection against cellular damage caused by reactive oxygen species. Research suggests that an increased intake of plant foods is associated with a reduced incidence of chronic disease...
2016: Current Pharmaceutical Biotechnology
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