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Obesity surgery trial

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https://www.readbyqxmd.com/read/29344438/new-therapeutic-approaches-in-obesity-and-metabolic-syndrome-associated-with-polycystic-ovary-syndrome
#1
REVIEW
Fatima Saleem, Syed W Rizvi
Polycystic ovary syndrome (PCOS) is a pathophysiological disorder affecting reproductive and metabolic indices. PCOS is commonly associated with a high prevalence of insulin resistance and obesity; this association carries an increased risk of developing metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Guidelines recommend lifestyle modification, metformin, hormonal contraceptives (HCs), and bariatric surgery as the main treatment options in obese patients with PCOS. Studies are being conducted to test the efficacy of existing treatment options as well as to discover new therapies...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29343248/minimally-invasive-versus-open-transforaminal-lumbar-interbody-fusion-in-obese-patients-a-meta-analysis
#2
Qingsong Xie, Jing Zhang, Feng Lu, Hao Wu, Zan Chen, Fengzeng Jian
BACKGROUND: Minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) has been employed in increasing cases compared with open TLIF (Open-TLIF). However, it is uncertain whether the advantages of MI-TLIF can also be specifically applied in obese patients. Therefore, the current study was thereby carried out aiming to compare the outcomes of MI-TLIF with those of Open-TLIF in obese patients with lumbar degenerative diseases. METHODS: Electronic databases were systemically retrieved from construction to May 2017...
January 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29340679/effect-of-laparoscopic-sleeve-gastrectomy-vs-laparoscopic-roux-en-y-gastric-bypass-on-weight-loss-in-patients-with-morbid-obesity-the-sm-boss-randomized-clinical-trial
#3
Ralph Peterli, Bettina Karin Wölnerhanssen, Thomas Peters, Diana Vetter, Dino Kröll, Yves Borbély, Bernd Schultes, Christoph Beglinger, Jürgen Drewe, Marc Schiesser, Philipp Nett, Marco Bueter
Importance: Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs the standard Roux-en-Y gastric bypass procedure is unknown. Objective: To determine whether there are differences between sleeve gastrectomy and Roux-en-Y gastric bypass in terms of weight loss, changes in comorbidities, increase in quality of life, and adverse events. Design, Setting, and Participants: The Swiss Multicenter Bypass or Sleeve Study (SM-BOSS), a 2-group randomized trial, was conducted from January 2007 until November 2011 (last follow-up in March 2017)...
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29340678/lifestyle-intervention-and-medical-management-with-vs-without-roux-en-y-gastric-bypass-and-control-of-hemoglobin-a1c-ldl-cholesterol-and-systolic-blood-pressure-at-5-years-in-the-diabetes-surgery-study
#4
COMMENT
Sayeed Ikramuddin, Judith Korner, Wei-Jei Lee, Avis J Thomas, John E Connett, John P Bantle, Daniel B Leslie, Qi Wang, William B Inabnet, Robert W Jeffery, Keong Chong, Lee-Ming Chuang, Michael D Jensen, Adrian Vella, Leaque Ahmed, Kumar Belani, Charles J Billington
Importance: The Roux-en-Y gastric bypass is effective in achieving established diabetes treatment targets, but durability is unknown. Objective: To compare durability of Roux-en-Y gastric bypass added to intensive lifestyle and medical management in achieving diabetes control targets. Design, Setting, and Participants: Observational follow-up of a randomized clinical trial at 4 sites in the United States and Taiwan, involving 120 participants who had a hemoglobin A1c (HbA1c) level of 8...
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29340677/association-of-bariatric-surgery-using-laparoscopic-banding-roux-en-y-gastric-bypass-or-laparoscopic-sleeve-gastrectomy-vs-usual-care-obesity-management-with-all-cause-mortality
#5
Orna Reges, Philip Greenland, Dror Dicker, Morton Leibowitz, Moshe Hoshen, Ilan Gofer, Laura J Rasmussen-Torvik, Ran D Balicer
Importance: Bariatric surgery is an effective and safe approach for weight loss and short-term improvement in metabolic disorders such as diabetes. However, studies have been limited in most settings by lack of a nonsurgical group, losses to follow-up, missing data, and small sample sizes in clinical trials and observational studies. Objective: To assess the association of 3 common types of bariatric surgery compared with nonsurgical treatment with mortality and other clinical outcomes among obese patients...
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29334691/a-meta-analysis-of-the-effects-of-bariatric-surgery-on-fracture-risk
#6
REVIEW
Q Zhang, Y Chen, J Li, D Chen, Z Cheng, S Xu, Y Huang, Q Wang
Bariatric surgery effectively treats morbid obesity. However, the negative effect of this surgery on the bone is concerning. The aim of this meta-analysis was to investigate the fracture risk associated with bariatric surgery in morbidly obese subjects. Relevant studies published from database inception to September 2017 were identified in PubMed, Embase and the Cochrane Library. The Newcastle-Ottawa Scale was used to evaluate the quality of the observational studies, and the Jadad score evaluated randomized controlled trials...
January 15, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29310829/-sugammadex-by-ideal-body-weight-versus-20-and-40-corrected-weight-in-bariatric-surgery-double-blind-randomized-clinical-trial
#7
Nádia Maria da Conceição Duarte, Ana Maria Menezes Caetano, Silvio da Silva Caldas Neto, Getúlio Rodrigues de Oliveira Filho, Gustavo de Oliveira Arouca, Josemberg Marins Campos
BACKGROUND AND OBJECTIVES: The weight parameters for use of sugammadex in morbidly obese patients still need to be defined. METHODS: A prospective clinical trial was conducted with sixty participants with body mass index≥40kg·m-2 during bariatric surgery, randomized into three groups: ideal weight (IW), 20% corrected body weight (CW20) and 40% corrected body weight (CW40). All patients received total intravenous anesthesia. Rocuronium was administered at dose of 0...
January 5, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29306619/comparative-study-between-conventional-fasting-versus-overnight-infusion-of-lipid-or-carbohydrate-on-insulin-and-free-fatty-acids-in-obese-patients-undergoing-elective-on-pump-coronary-artery-bypass-grafting-a-prospective-randomized-trial
#8
Hisham Hosny, Mohamed Ibrahim, Wael El-Siory, Amr Abdel-Monem
OBJECTIVES: Postoperative insulin resistance represents a major component of postoperative metabolic disorder. The authors compared the effects of preoperative infusion of lipid emulsion or carbohydrate to conventional preoperative fasting on postoperative insulin and free fatty acid (FFA) levels. DESIGN: A prospective randomized double-blinded study. SETTINGS: Tertiary university hospital. PARTICIPANTS: Sixty-three patients undergoing coronary artery bypass grafting...
November 24, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29306011/adaptation-of-human-gut-microbiota-to-bariatric-surgeries-in-morbidly-obese-patients-a-systematic-review
#9
Hanieh-Sadat Ejtahed, Pooneh Angoorani, Shirin Hasani-Ranjbar, Seyed-Davar Siadat, Nasrin Ghasemi, Bagher Larijani, Ahmad-Reza Soroush
BACKGROUND: Bariatric surgeries have turned to be a popular therapeutic option for morbid obesity nowadays. Gut microbiota is supposed to be responsible as a part of the bariatric surgeries success. In this systematic review, we detailed the human studies which investigated the effect of different bariatric surgeries on the composition of gut microbiota. METHODS: We did a comprehensive search in PubMed, Web of Science, and Scopus for all clinical trials and longitudinal observational studies documented up to December 2015...
January 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29305792/analgesic-effect-of-intraperitoneal-bupivacaine-hydrochloride-after-laparoscopic-sleeve-gastrectomy-a-randomized-clinical-trial
#10
Nasser Malekpour Alamdari, Mahmood Bakhtiyari, Barmak Gholizadeh, Catrine Shariati
BACKGROUND: The indications for sleeve gastrectomy as a primary procedure for the surgical treatment of morbid obesity have increased worldwide. Pain is the most common complaint for patients on the first day after laparoscopic sleeve gastrectomy. There are various methods for decreasing pain after laparoscopic sleeve gastrectomy such as the use of intraperitoneal bupivacaine hydrochloride. This clinical trial was an attempt to discover the effects of intraperitoneal bupivacaine hydrochloride on alleviating postoperative pain after laparoscopic sleeve gastrectomy...
January 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29304473/bariatric-surgery-as-a-risk-factor-in-the-development-of-dental-caries-a-systematic-review
#11
REVIEW
A O Salgado-Peralvo, M V Mateos-Moreno, L Arriba-Fuente, Á García-Sánchez, A Salgado-García, V Peralvo-García, M Millán-Yanes
OBJECTIVES: Obesity is one of the most prevalent chronic pathologies in the world and has become a public health problem. At the present time, bariatric surgery (BS) is considered the best option and the only effective method of treatment, but it can occasionally result in a series of alterations at the oral level. This study aims to review the current literature to establish the possible association of patients who have undergone BS and a greater risk of dental caries. STUDY DESIGN: This study is a systematic review of the literature...
January 2, 2018: Public Health
https://www.readbyqxmd.com/read/29304140/long-term-effects-of-manual-lymphatic-drainage-and-active-exercises-on-physical-morbidities-lymphoscintigraphy-parameters-and-lymphedema-formation-in-patients-operated-due-to-breast-cancer-a-clinical-trial
#12
Mariana Maia Freire de Oliveira, Maria Salete Costa Gurgel, Bárbara Juarez Amorim, Celso Dario Ramos, Sophie Derchain, Natachie Furlan-Santos, César Cabello Dos Santos, Luís Otávio Sarian
PURPOSE: evaluate whether manual lymphatic drainage (MLD) or active exercise (AE) is associated with shoulder range of motion (ROM), wound complication and changes in the lymphatic parameters after breast cancer (BC) surgery and whether these parameters have an association with lymphedema formation in the long run. METHODS: Clinical trial with 106 women undergoing radical BC surgery, in the Women's Integrated Healthcare Center-University of Campinas. Women were matched for staging, age and body mass index and were allocated to performed AE or MLD, 2 weekly sessions during one month after surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29303847/obesity-in-the-workplace-impact-outcomes-and-recommendations
#13
Charles M Yarborough, Stacy Brethauer, Wayne N Burton, Raymond J Fabius, Pamela Hymel, Shanu Kothari, Robert F Kushner, John Magaña Morton, Kathryn Mueller, Nicolaas P Pronk, Mitchell S Roslin, David B Sarwer, Brian Svazas, Jeffrey S Harris, Garrett I Ash, Jamie T Stark, Marianne Dreger, Julie Ording
OBJECTIVE: To conduct a comprehensive literature review to develop recommendations for managing obesity among workers to improve health outcomes and to explore the impact of obesity on health costs to determine whether a case can be made for surgical interventions and insurance coverage. METHODS: We searched PubMed from 2011 to 2016, and CINAHL, Scopus, and Cochrane Registry of Clinical Trials for interventions addressing obesity in the workplace. RESULTS: A total of 1419 articles were screened, resulting in 275 articles being included...
January 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29298749/importance-of-active-participation-in-obesity-management-through-mobile-health-care-programs-substudy-of-a-randomized-controlled-trial
#14
Bumjo Oh, Ga-Hye Yi, Min Kyu Han, Jong Seung Kim, Chang Hee Lee, Belong Cho, Hee Cheol Kang
BACKGROUND: Due to the prevalence of the westernized dietary pattern and lack of physical activity, the numbers of overweight or obese individuals are increasing, resulting in a growing health burden because of various related diseases. A lifestyle modification approach has additional advantages compared with pharmacological therapies or bariatric surgery. In our randomized controlled trial conducted in 2015, we successfully used a ubiquitous health care (SmartCare) service for patients with metabolic syndrome to achieve a significant weight loss effect...
January 3, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29290130/women-fare-best-following-surgery-for-degenerative-lumbar-spondylolisthesis-a-comparison-of-the-most-and-least-satisfied-patients-utilizing-data-from-the-quality-outcomes-database
#15
Andrew K Chan, Erica F Bisson, Mohamad Bydon, Steven D Glassman, Kevin T Foley, Eric A Potts, Christopher I Shaffrey, Mark E Shaffrey, Domagoj Coric, John J Knightly, Paul Park, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Panagiotis Kerezoudis, Silky Chotai, Anthony M DiGiorgio, Alvin Y Chan, Regis W Haid, Praveen V Mummaneni
OBJECTIVE The American Association of Neurological Surgeons launched the Quality Outcomes Database (QOD), a prospective longitudinal registry that includes demographic, clinical, and patient-reported outcome (PRO) data, to measure the safety and quality of neurosurgical procedures, including spinal surgery. Differing results from recent randomized controlled trials have established a need to clarify the groups that would most benefit from surgery for degenerative lumbar spondylolisthesis. In the present study, the authors compared patients who were the most and the least satisfied following surgery for degenerative lumbar spondylolisthesis...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29284576/effect-of-obesity-on-total-ankle-arthroplasty-a-systematic-review-of-postoperative-complications-requiring-surgical-revision
#16
REVIEW
Laura E Sansosti, Jennifer C Van, Andrew J Meyr
Total ankle arthroplasty has become an increasingly used alternative to ankle arthrodesis for the treatment of end-stage ankle arthritis. However, despite progressive technological advances and the advent of multiple commercial implant systems, some concern remains for the relatively high complication and failure rates. The objective of the present investigation was to perform a systematic review of the incidence of complications in obese patients undergoing total ankle arthroplasty. We performed a review of electronic databases with the inclusion criteria of retrospective case series, retrospective clinical cohort analyses, and prospective clinical trials with ≥15 total participants, a mean follow-up period of ≥12 months, ≥1 defined cohort with a body mass index of ≥30 kg/m2, and a reported incidence rate of complications requiring revisional surgery at the final follow-up point...
December 25, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29282115/efficacy-of-anchoring-the-four-arm-transvaginal-mesh-to-the-mid-urethra-vs-original-surgery-as-a-surgical-correction-for-stress-urine-incontinence-in-coexisting-anterior-vaginal-prolapse-grades-ii-and-iii-study-protocol-for-a-randomized-controlled-trial
#17
Zoltán Fekete, Andrea Surányi, Lórand Rénes, Gábor Németh, Zoltan Kozinszky
BACKGROUND: The prevalence of obesity with aging is escalating alarmingly; and pelvic organ prolapse (POP) and stress urinary incontinence (SUI) are now becoming a growing epidemic among the elderly. Synthetic transvaginal mesh has been employed with increasing popularity in the treatment of POP and is usually highly effective in controlling the principal symptoms of prolapse. However, studies have reported that mesh operations provide fairly unfavorable SUI cure rates. Therefore, additional anti-incontinence surgical strategies are increasingly being scrutinized to achieve better postoperative continence without any significant side-effects for patients with both POP and SUI...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29277633/which-place-of-pharmacological-approaches-beyond-continuous-positive-airway-pressure-to-treat-vascular-disease-related-to-obstructive-sleep-apnea
#18
REVIEW
Elodie Gautier-Veyret, Jean-Louis Pépin, Françoise Stanke-Labesque
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial or complete upper airway obstruction, occurring during sleep, leading to chronic intermittent hypoxia (IH), which harms the cardiovascular system. OSA is associated with both functional and structural vascular alterations that contribute to an increased prevalence of fatal and non-fatal cardiovascular events. OSA is a heterogeneous disease with respect to the severity of hypoxia, the presence of daytime symptoms, obesity, and cardiovascular comorbidities...
December 22, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29242649/dose-reversal-effect-relationship-of-three-different-doses-of-neostigmine-in-obese-patients-a-randomised-clinical-trial
#19
Satyen Parida, Venkatesan Kausalya, Sandeep Kumar Mishra, Sethuramachandran Adinarayanan
Background and Aims: Previous studies suggest that administration of vecuronium based on total body weight rather than ideal body weight (IBW) in obesity results in overdosing with prolonged recovery times. We hypothesised that larger doses of neostigmine could result in faster recovery in obese patients administered vecuronium based on total body weight. Methods: Forty-five obese American Society of Anesthesiologists' II patients undergoing elective surgery under general anaesthesia were randomised into 3 groups to receive neostigmine 30, 40 and 50 μg/kg...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29239795/effects-of-very-low-calorie-diets-on-liver-size-and-weight-loss-in-the-preoperative-period-of-bariatric-surgery-a-systematic-review
#20
REVIEW
Mariana Holderbaum, Daniela Schaan Casagrande, Samanta Sussenbach, Caroline Buss
Restrictive diet implementation in bariatric surgery (BS) preoperative period is common, although its benefits are not well established. This study aimed to assess the effects of very low calorie diets (VLCD) on liver size and weight loss during BS preoperative period. Surgery-related complications were also assessed. A systematic review of the literature was performed. Terms such as "bariatric surgery" and "very low energy diet" were included in the search strategy. Inclusion criteria were adult patients (aged>18 yr); VLCD treatment in BS preoperative period (10 d to 12 wk); and assessment of 1 the following outcomes: weight loss, liver volume reduction, and surgical complications...
October 2, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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