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Obesity surgery trial

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https://www.readbyqxmd.com/read/29778650/obesity-surgery-makes-patients-healthier-and-more-functional-real-world-results-from-the-united-kingdom-national-bariatric-surgery-registry
#1
Alexander Dimitri Miras, Kamocka Anna, Patel Darshan, Dexter Simon, Finlay Ian, Hopkins C James, Khan Omar, Reddy Marcus, Sedman Peter, Small Peter, Somers Shaw, Suzie Cro, Walton Peter, le Roux Carel W, Welbourn Richard
BACKGROUND: The National Bariatric Surgery Registry (NBSR) is the largest bespoke database in the field in the United Kingdom. OBJECTIVES: Our aim was to analyze the NBSR to determine whether the effects of obesity surgery on associated co-morbidities observed in small, randomized controlled clinical trials could be replicated in a "real life" setting within U.K. healthcare. SETTING: United Kingdom. METHODS: All NBSR entries for operations between 2000 and 2015 with associated demographic and co-morbidity data were analyzed retrospectively...
February 15, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29752333/the-endocrinology-of-male-breast-cancer
#2
REVIEW
Ian S Fentiman
Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2 ) levels from hepatic conversion of androgen...
June 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29748734/selection-of-bypass-vs-sleeve-for-the-management-of-type-2-diabetes-in-severely-obese-could-ethnicity-play-a-role
#3
Aparna Govil Bhasker, John B Dixon, Muffazal Lakdawala
PURPOSE: Prospective data was evaluated to see whether bariatric procedure type made any difference to diabetes remission. METHODS: One hundred eighty-six consecutive patients of Indian ethnicity (M:F 89:97) with type 2 diabetes mellitus (T2DM) and HbA1c > 6.5 were assessed before and at 1 year following surgery. Age, BMI, C-peptide and duration of diabetes (ABCD - described by WJ Lee), insulin use, baseline HbA1c, and % weight loss were tested as modifiers...
May 10, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29725975/probiotic-supplementation-in-morbid-obese-patients-undergoing-one-anastomosis-gastric-bypass-mini-gastric-bypass-oagb-mgb-surgery-a-randomized-double-blind-placebo-controlled-clinical-trial
#4
Zohreh Karbaschian, Zeinab Mokhtari, Abdolreza Pazouki, Ali Kabir, Mahdi Hedayati, Somayeh Soleymanzadeh Moghadam, Parvin Mirmiran, Azita Hekmatdoost
BACKGROUND: Bariatric surgery is known as one of the most effective treatments for sustainable weight loss; however, it may be associated with some complications. This study was designed to examine the effects of probiotic supplementation on some morbidities related to this surgery. METHODS: This was a placebo-controlled, double-blind, randomized clinical trial on morbid obese patients referred for One Anastomosis Gastric Bypass- Mini Gastric Bypass (OAGB-MGB) surgery to a tertiary referral center...
May 3, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29690917/health-consequences-for-mother-and-baby-of-substantial-pre-conception-weight-loss-in-obese-women-study-protocol-for-a-randomized-controlled-trial
#5
Sarah Price, Alison Nankervis, Michael Permezel, Luke Prendergast, Priya Sumithran, Joseph Proietto
BACKGROUND: Current guidelines for the management of obesity in women planning pregnancy suggest lifestyle modification before conception. However, there is little evidence that lifestyle modification alters pregnancy outcomes. Bariatric surgery results in significant weight loss. This appears to reduce the risk of adverse pregnancy outcomes for the mother but may increase the risk of adverse outcomes for the infant. In order to reduce the risks of obesity-related adverse pregnancy outcomes for both mother and offspring, alternative approaches to the management of obesity in women planning pregnancy are needed...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29689646/beyond-lifestyle-interventions-exploring-the-potential-of-anti-obesity-medications-in-the-uk
#6
REVIEW
J P H Wilding
In the UK, over one-quarter of the adult population have obesity (body mass index ≥30 kg m-2 ). This has major implications for patients' health and the National Health Service. Despite published studies showing that significant weight loss can be achieved and maintained in primary care, and guidance from the National Institute for Health and Care Excellence, weight management services are inconsistently implemented. This may be due primarily to workload and financial constraints. There is also a lack of belief that specialist weight management services and anti-obesity medications (AOMs) are a viable alternative to bariatric surgery for long-term maintenance of weight loss...
April 24, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29683196/hypogonadism-and-male-obesity-focus-on-unresolved-questions
#7
Mathis Grossmann
Obesity, increasing in prevalence globally, is the clinical condition most strongly associated with lowered testosterone concentrations in men, and presents as one of the strongest predictors of receiving testosterone treatment. While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression. HPT axis suppression is likely mediated via pro-inflammatory cytokine and dysregulated leptin signalling and aggravated by associated comorbidities...
April 23, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29680836/endoscopic-duodenal-mucosal-resurfacing-for-the-treatment-of-type-2-diabetes
#8
Alia Hadefi, Vincent Huberty, Arnaud Lemmers, Marianna Arvanitakis, David Maggs, Guido Costamagna, Jacques Devière
Type 2 diabetes is a pandemic disease with an incidence that has risen steadily over recent decades. Experimental evidence in animals has demonstrated that intestinal bypass surgery of the upper small intestine, particularly the duodenum, has an important role in glucose homoeostasis. Furthermore, Roux-en-Y bypass performed as bariatric surgery has shown to correct hyperglycaemia from the first postoperative days in obese diabetic patients. Therefore, on the basis of these considerations, duodenal mucosal resurfacing was studied in type 2 diabetes patients as a minimally invasive procedure that could offer an alternative treatment for these patients...
April 20, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29679334/metabolic-surgery-and-diabesity-a-systematic-review
#9
REVIEW
Lionel El Khoury, Elie Chouillard, Elias Chahine, Elias Saikaly, Tarek Debs, Radwan Kassir
Bariatric surgery is used to induce weight loss (baros = weight). Evidence has shown that bariatric surgery improves the comorbid conditions associated with obesity such as hypertension, hyperlipidemia, and type 2 diabetes mellitus T2DM. Hence, shifting towards using metabolic surgery instead of bariatric surgery is currently more appropriate in certain subset of patients. Endocrine changes resulting from operative manipulation of the gastrointestinal tract after metabolic surgery translate into metabolic benefits with respect to the comorbid conditions...
April 20, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29679149/totally-endoscopic-implant-to-effect-a-gastric-bypass-12-month-safety-and-efficacy-outcomes
#10
Bryan J Sandler, Laurent Biertho, Mehran Anvari, Roberto Rumbaut, Luis Alonso Morales-Garza, Gustavo Torres-Barrera, Simon Marceau, Dennis Hong, C Daniel Smith, Santiago Horgan
BACKGROUND: Only a small percentage of candidates for bariatric surgery ever undergo a procedure for weight loss. Devices duplicating key effects of bariatric surgeries with removable, fully trans-oral implants could extend their benefits to patients unwilling to undergo anatomy-altering abdominal surgeries. METHODS: Thirty-two obese subjects (mean BMI: 42.3) were enrolled in a prospective, multicenter, single-arm, feasibility trial of the first fully trans-oral endoscopic gastrointestinal bypass device...
April 20, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29678127/a-health-economic-model-to-assess-the-cost-effectiveness-of-optifast-%C3%A2-for-the-treatment-of-obesity-in-usa
#11
Mark Nuijten, Agnieszka Marczewska, Krysmaru Araujo Torress, Bahareh Rasouli, Moreno Perugini
OBJECTIVES: Obesity is associated with high direct medical costs and indirect costs resulting from productivity loss. High prevalence of obesity generates a justified need to identify cost-effective weight loss approaches from a payer's perspective. Within the variety of weight management techniques, OPTIFAST® is a clinically recognized and scientifically proven total meal replacement Low Calorie Diet that provides meaningful results in terms of weight loss and reduction in comorbidities...
April 20, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29677629/effects-of-gastric-bypass-surgery-followed-by-supervised-physical-training-on-inflammation-and-endothelial-function-a-randomized-controlled-trial
#12
Charlotte Røn Stolberg, Lene Hymøller Mundbjerg, Peter Funch-Jensen, Bibi Gram, Else-Marie Bladbjerg, Claus Bogh Juhl
BACKGROUND AND AIMS: Obesity and physical inactivity are both associated with low-grade inflammation and endothelial dysfunction. Bariatric surgery improves markers of inflammation and endothelial function, but it is unknown if physical training after bariatric surgery can improve these markers even further. Therefore, we aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) followed by physical training on markers of low-grade inflammation and endothelial function. METHODS: Sixty patients approved for RYGB underwent examinations pre-surgery, 6, 12, and 24 months post-surgery...
April 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29659692/bone-health-following-bariatric-surgery-implications-for-management-strategies-to-attenuate-bone-loss
#13
Tair Ben-Porat, Ram Elazary, Shiri Sherf-Dagan, Ariela Goldenshluger, Ronit Brodie, Yoav Mintz, Ram Weiss
Bariatric surgery (BS) is an effective treatment for morbid obesity and its associated comorbidities. Following such a procedure, however, patients are at risk of developing metabolic bone disease owing to the combination of rapid weight loss, severely restricted dietary intake, and reduced intestinal nutrient absorption. Patients undergoing malabsorptive procedures are at a higher risk of postoperative bone health deterioration than those undergoing restrictive procedures; however, studies have demonstrated negative skeletal consequences of restrictive procedures as well...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29617634/surgical-weight-loss-to-improve-functional-status-trajectories-following-total-knee-arthroplasty-swift-trial-rationale-design-and-methods
#14
Peter N Benotti, Christopher D Still, G Craig Wood, Jamie L Seiler, Christopher J Seiler, Shane P Thomas, Anthony T Petrick, Michael Suk, Brian A Irving
Total Knee Arthroplasty (TKA, also known as total knee replacement) is a highly effective surgical intervention for the restoration of physical function and improving quality of life in patients with disabling knee osteoarthritis. Recent data suggest that obesity is a major risk factor in the pathogenesis and progression of knee osteoarthritis, with increases in body mass index (BMI, kg/m2 ) directly correlating with the prevalence of knee osteoarthritis. However, recent data also suggest that there are increased risks associated with TKAs when performed in patients with morbid obesity (BMI > 40 kg/m2 )...
April 1, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29590421/incidence-of-hypoglycemia-after-gastric-bypass-versus-sleeve-gastrectomy-a-randomized-trial
#15
Esmeralda Capristo, Simona Panunzi, Andrea De Gaetano, Valerio Spuntarelli, Rocco Bellantone, Piero Giustacchini, Andreas L Birkenfeld, Stephanie Amiel, Stefan R Bornstein, Marco Raffaelli, Geltrude Mingrone
Contest-&-Objective: We compared the incidence of hypoglycemia after Roux-en-Y-Gastric-Bypass (RYGB) versus Sleeve Gastrectomy (SG). Design-Setting-and- Main Outcome Measure: Randomized, open-label trial conducted at the outpatient obesity-clinic in a university-hospital in Rome, Italy. The primary aim was the incidence of reactive hypoglycemia (<3.1 mmol/l after 75g-oral-glucose-load) at 1 year after surgery (intention-to-treat-analysis, carried-forward for missing data)...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589076/-robot-assisted-vs-laparoscopic-gastric-bypass-first-experiences-with-the-davinci-system-in-bariatric-surgery
#16
J H Beckmann, H Aselmann, J H Egberts, A Bernsmeier, M Laudes, T Becker, C Schafmayer, M Ahrens
Conventional laparoscopy is the gold standard in bariatric surgery. Internationally, robot-assisted surgery is gaining in importance. Up to now there are only few reports from Germany on the use of the system in bariatric surgery. Since January 2017 we have been performing robot-assisted gastric bypass surgery. It remains unclear whether the use of the robotic system has advantages over the well-established laparoscopic technique. Within a period from January to early August 2017 a total of 53 gastric bypass operations were performed...
March 27, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29576234/usefulness-of-statins-for-prevention-of-venous-thromboembolism
#17
REVIEW
Patricia Chaffey, Mary Thompson, Ajit D Pai, Ali R Tafreshi, Javad Tafreshi, Ramdas G Pai
Venous thromboembolism (VTE), including deep venous thrombosis and pulmonary embolism, is common with an annual incidence of 1 to 5 per 1,000, resulting in major morbidity, mortality, and increased health care costs. It is more common in the elderly, obese, those with cancer, those undergoing surgery, and those with previous VTE. Strategy to reduce its occurrence has important public health implications. Pleotropic effects of statins may have beneficial effects on a number of potential targets associated with VTE...
March 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29567055/long-term-follow-up-of-disease-specific-quality-of-life-after-bariatric-surgery
#18
Simon Biron, Laurent Biertho, Simon Marceau, Yves Lacasse
BACKGROUND: Substantial improvements in health-related quality of life measured by generic questionnaires (most often the Short Form-36) have been noted over the long term in patients with morbid obesity who had undergone bariatric surgery. OBJECTIVES: To obtain long-term follow-up data on disease-specific quality of life in patients who underwent bariatric surgery (biliopancreatic diversion with duodenal switch) in 2007 to 2008. SETTING: Québec Heart and Lung Institute, Québec, Canada...
February 13, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29566463/supervised-physical-training-improves-weight-loss-after-roux-en-y-gastric-bypass-surgery-a-randomized-controlled-trial
#19
Lene Hymøller Mundbjerg, Charlotte Røn Stolberg, Stefano Cecere, Else-Marie Bladbjerg, Peter Funch-Jensen, Bibi Gram, Claus Bogh Juhl
OBJECTIVE: Bariatric surgery results in significant weight loss and reduces cardiovascular morbidity. However, a large variation in postsurgery weight loss is seen. Physical activity promotes weight loss in nonsurgically treated subjects with obesity. The aim of this study was to investigate the effects of 6 months of supervised physical training following Roux-en-Y gastric bypass surgery (RYGB) on body weight and cardiovascular risk markers. METHODS: Sixty participants eligible for RYGB were included...
May 2018: Obesity
https://www.readbyqxmd.com/read/29536158/comparative-study-of-the-treatment-of-20-30-mm-renal-stones-with-miniaturized-percutaneous-nephrolithotomy-and-flexible-ureterorenoscopy-in-obese-patients
#20
He-Qun Chen, Zhi-Yong Chen, Feng Zeng, Yang Li, Zhong-Qing Yang, Cheng He, Yao He
PURPOSE: To evaluate and compare flexible ureteroscopy (f-URS) and mini-percutaneous nephrolithotomy (mPNL) for 20-30 mm renal stones in obese patients regarding efficacy and safety. METHODS: Between May 2011 and June 2017, 254 obese patients who had 20-30 mm kidney stone were consecutively included in the study; 106 patients underwent mPNL and 148 underwent f-URS by the same surgeon. The following parameters were retrospectively assessed: patient and stone characteristics, surgical details, perioperative outcomes, and stone-free rates (SFR)...
March 13, 2018: World Journal of Urology
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