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https://www.readbyqxmd.com/read/28642204/co-delivery-of-paclitaxel-and-anti-survivin-sirna-via-redox-sensitive-oligopeptide-liposomes-for-the-synergistic-treatment-of-breast-cancer-and-metastasis
#1
Xinyan Chen, Yidi Zhang, Chunming Tang, Chunli Tian, Qiong Sun, Zhigui Su, Lingjing Xue, YifanYin, Caoyun Ju, Can Zhang
The overexpression of survivin in breast cancer cells is an important factor of paclitaxel (PTX) resistance in breast cancer. To overcome PTX resistance and improve the antitumor effect of PTX, we developed a novel liposome-based nanosystem (PTX/siRNA/SS-L), composed of a redox-sensitive cationic oligopeptide lipid (LHSSG2C14) with a proton sponge effect, natural soybean phosphatidylcholine (SPC), and cholesterol for co-delivery of PTX and anti-survivin siRNA, which could specifically downregulate survivin overexpression...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28638484/surface-de-pegylation-controls-nanoparticle-mediated-sirna-delivery-in-vitro-and-in-vivo
#2
Xi Zhu, Wei Tao, Danny Liu, Jun Wu, Zilei Guo, Xiaoyuan Ji, Zameer Bharwani, Lili Zhao, Xiaoping Zhao, Omid C Farokhzad, Jinjun Shi
The present work proposes a unique de-PEGylation strategy for controllable delivery of small interfering RNA (siRNA) using a robust lipid-polymer hybrid nanoparticle (NP) platform. The self-assembled hybrid NPs are composed of a lipid-poly(ethylene glycol) (lipid-PEG) shell and a polymer/cationic lipid solid core, wherein the lipid-PEG molecules can gradually dissociate from NP surface in the presence of serum albumin. The de-PEGylation kinetics of a series of different lipid-PEGs is measured with their respective NPs, and the NP performance is comprehensively investigated in vitro and in vivo...
2017: Theranostics
https://www.readbyqxmd.com/read/28627891/effect-of-deep-eutectic-solvent-nanostructure-on-phospholipid-bilayer-phases
#3
Saffron Jade Bryant, Rob Atkin, Gregory G Warr
Phospholipids are shown by solvent penetration experiments to form lamellar phases and spontaneously spawn vesicles in a wide range of deep eutectic solvents (DESs) composed of alkylammonium halide salts and glycerol or ethylene glycol, which are shown to be nanostructured by X-ray scattering. In contrast with molecular solvents, the chain melting temperature of each phospholipid, which determines the stability of the swellable bilayer phase, depends on the structure of the cation, anion and molecular H-bond donor that constitute the DES...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28623231/cry6aa1-a-bacillus-thuringiensis-nematocidal-and-insecticidal-toxin-forms-pores-in-planar-lipid-bilayers-at-extremely-low-concentrations-and-without-the-need-of-proteolytic-processing
#4
Eva Fortea, Vincent Lemieux, Léna Potvin, Vimbai Chikwana, Samantha Griffin, Thimothy Hey, David McCaskill, Kenneth Narva, Sek Yee Tan, Xiaoping Xu, Vincent Vachon, Jean-Louis Schwartz
Cry6Aa1 is a Bacillus thuringiensis (Bt) toxin active against nematodes and corn rootworm insects. Its 3-D molecular structure, which has been recently elucidated, is unique among those known for other Bt toxins. Typical three-domain Bt toxins permeabilise receptor-free planar lipid bilayers (PLBs) by forming pores at doses in the 1-50 μg/ml range. Solubilisation and proteolytic activation are necessary steps for PLB permeabilisation. In contrast to other Bt toxins, Cry6Aa1 formed pores in receptor-free bilayers at doses as low as 200 pg/ml in a wide range of pH (5...
June 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28620299/the-alkamide-trans-pellitorine-targets-ppar%C3%AE-via-trpv1-and-trpa1-to-reduce-lipid-accumulation-in-developing-3t3-l1-adipocytes
#5
Barbara Lieder, Mathias Zaunschirm, Ann-Katrin Holik, Jakob P Ley, Joachim Hans, Gerhard E Krammer, Veronika Somoza
Adipose tissue is an important endocrine organ in the human body. However, pathological overgrowth is associated with chronic illness. Regulation of adipogenesis and maturation of adipocytes via bioactive compounds in our daily diet has been in focus of research in the past years and showed promising results for agonists of the ion channels transient receptor potential channel (TRP) V1 and A1. Here, we investigated the anti-adipogenic potential and underlying mechanisms of the alkamide trans-pellitorine present in Piper nigrum via TRPV1 and TRPA1 in 3T3-L1 cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28614663/electrochemically-triggered-release-of-reagent-to-the-proximal-leaflet-of-a-microcavity-supported-lipid-bilayer
#6
Hajra Basit, Sean Maher, Robert J Forster, Tia E Keyes
A novel and versatile approach to electrichemically triggering the release of a reagent, β-Cyclodextrin (β-CD), selectively to the proximal leaflet of a supported lipid bilayer, is described. Selective delivery is achieved by creating a spanning lipid bilayer across a microcavity array and exploiting the irreversible redox disassembly of the host-guest complex formed between thiolated Ferrocene (Fc) and β-Cyclodextrin (β-CD) in the presence of chloride. Self-assembled monolayers of the Ferrocene-alkanethiols were formed regioselectively on the interior surface of highly ordered 2...
June 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28610721/cationic-liposomal-vectors-incorporating-a-bolaamphiphile-for-oligonucleotide-antimicrobials
#7
Marianna Mamusa, Leopoldo Sitia, Francesco Barbero, Angels Ruyra, Teresa Díaz Calvo, Costanza Montis, Ana Gonzalez-Paredes, Grant N Wheeler, Christopher J Morris, Michael McArthur, Debora Berti
Antibacterial resistance has become a serious crisis for world health over the last few decades, so that new therapeutic approaches are strongly needed to face the threat of resistant infections. Transcription factor decoys (TFD) are a promising new class of antimicrobial oligonucleotides with proven in vivo activity when combined with a bolaamphiphilic cationic molecule, 12-bis-THA. These two molecular species form stable nanoplexes which, however, present very scarce colloidal stability in physiological media, which poses the challenge of drug formulation and delivery...
June 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28606715/the-interaction-of-antimicrobial-peptides-with-membranes
#8
REVIEW
Oksana G Travkova, Helmuth Moehwald, Gerald Brezesinski
The interaction of antimicrobial peptides (AMPs) with biological membranes is in the focus of research since several years, and the most important features and modes of action of AMPs are described in this review. Different model systems can be used to understand such interactions on a molecular level. As a special example, we use 2D and 3D model membranes to investigate the interaction of the natural cyclic (Ar-1) and the synthetic linear molecule arenicin with selected amphiphiles and phospholipids. A panoply of sophisticated methods has been used to analyze these interactions on a molecular level...
June 5, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28605233/clinoptilolite-for-treatment-of-dyslipidemia-preliminary-efficacy-study
#9
Milisav Cutovic, Milica Lazovic, Vesna Vukovic-Dejanovic, Dejan Nikolic, Ivana Petronic-Markovic, Dragana Cirovic
OBJECTIVES: A tribomechanically activated clinoptilolite (natural aluminosilicate mineral) has been used to increase growth in meat-producing animals, as an adjuvant in cancer therapy, and a heavy metal remover in humans. Because of its unique cation exchanging and chelating properties, we hypothesized that clinoptilolite may be beneficial for the treatment of dyslipidemia in the manner similar to bile acid sequestrants. Thus, specific aims of this pilot study were to orally administer clinoptilolite in different doses and granule size combinations to determine magnitude and time profile of changes in blood lipids...
June 12, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28603974/evolution-of-new-bolaliposomes-using-novel-%C3%AF-tocopheryl-succinate-based-cationic-lipid-and-1-12-disubstituted-dodecane-based-bolaamphiphile-for-efficient-gene-delivery
#10
Mallikarjun Gosangi, Hithavani Rapaka, Venkatesh Ravula, Srilakshmi Venkata Patri
Non-viral lipid based vectors are promising transporting systems for the intracellular delivery of therapeutic gene sequences and directly influence the success of gene delivery. However, the associated drawbacks like lower transfection, toxicity and targetability with which demands further improvisation. Towards this goal, herein, we report a novel lipid formulation by mixing two distinct cationic surfactants such as tocopheryl succinate based cationic lipid and 1, 12 dodecane based bolaamphiphile and is proved as good transfection reagent with its competing potential with "golden" standard, Lipofectamine 3000 (L3K)...
June 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28585089/combination-of-cationic-dexamethasone-derivative-and-stat3-inhibitor-wp1066-for-aggressive-melanoma-a-strategy-for-repurposing-a-phase-i-clinical-trial-drug
#11
Samaresh Sau, Sujan Kumar Mondal, Sushil K Kashaw, Arun K Iyer, Rajkumar Banerjee
Glucocorticoid, such as dexamethasone (Dex) is often used along with chemotherapy to antagonize side effects of chemotherapy. However, sustained use of Dex frequently develops drug resistance in patients. As a strategy to re-induce drug sensitivity, we planned to modify Dex by chemically conjugating it with twin ten carbon aliphatic chain containing cationic lipid. The resultant molecule, DX10, inhibited STAT3 activation through lowering the production of IL-6. To enhance the STAT3 inhibitory effect of DX10, we used WP (a commercially available STAT3 inhibitor) along with DX10...
June 5, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28582391/all-atom-nmda-receptor-transmembrane-domain-model-development-and-simulations-in-lipid-bilayers-and-water
#12
Samaneh Mesbahi-Vasey, Lea Veras, Michael Yonkunas, Jon W Johnson, Maria G Kurnikova
N-methyl-d-aspartate receptors (NMDARs) are members of the ionotropic glutamate receptor family that mediate excitatory synaptic transmission in the central nervous system. The channels of NMDARs are permeable to Ca2+ but blocked by Mg2+, distinctive properties that underlie essential brain processes such as induction of synaptic plasticity. However, due to limited structural information about the NMDAR transmembrane ion channel forming domain, the mechanism of divalent cation permeation and block is understood poorly...
2017: PloS One
https://www.readbyqxmd.com/read/28580138/plasma-membrane-association-facilitates-conformational-changes-in-the-marburg-virus-protein-vp40-dimer
#13
Nisha Bhattarai, Jeevan B Gc, Bernard S Gerstman, Robert V Stahelin, Prem P Chapagain
Filovirus infections cause hemorrhagic fever in humans and non-human primates that often results in high fatality rates. The Marburg virus is a lipid-enveloped virus from the Filoviridae family and is closely related to the Ebola virus. The viral matrix layer underneath the lipid envelope is formed by the matrix protein VP40 (VP40), which is also involved in other functions during the viral life-cycle. As in the Ebola virus VP40 (eVP40), the recently determined X-ray crystal structure of the Marburg virus VP40 (mVP40) features loops containing cationic residues that form a lipid binding basic patch...
April 26, 2017: RSC Advances
https://www.readbyqxmd.com/read/28577996/albumin-micro-nanoparticles-entrapping-liposomes-for-itraconazole-green-formulation
#14
María José de Jesús Valle, Cristina Maderuelo Martín, Aránzazu Zarzuelo Castañeda, Amparo Sánchez Navarro
Itraconazole-loaded micro/nanoparticles containing albumin and liposomes were prepared by a technological process that avoids the use of organic solvents and crosslinker agents. The particles were characterized, lyophilized and formulated as tablets. Dynamic light scattering was used to determine the hydrodynamic diameter and zeta potential of the particles; optical and scanning-electron microscopy was used to evaluate their morphology. Spherical shaped particles of different sizes and zeta potential were obtained...
June 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28570651/polydim-i-antimicrobial-activity-against-mdr-bacteria-and-its-model-membrane-interaction
#15
Marisa Rangel, Fabíola Fernandes Dos Santos Castro, Lilian Daiene Mota-Lima, Patricia Bianca Clissa, Danubia Batista Martins, Marcia Perez Dos Santos Cabrera, Marcia Renata Mortari
The rapid spread of multi-drug resistant pathogens represents a serious threat to public health, considering factors such as high mortality rates, treatment restrictions and high prevalence of multi-drug resistant bacteria in the hospital environment. Antimicrobial peptides (AMPs) may exhibit powerful antimicrobial activity against different and diverse microorganisms, also presenting the advantage of absence or low toxicity towards animal cells. In this study, the evaluation of the antimicrobial activity against multi-drug resistant bacteria of a recently described AMP from wasp, Polydim-I, was performed...
2017: PloS One
https://www.readbyqxmd.com/read/28570220/effects-of-rupatadine-on-platelet-activating-factor-induced-human-mast-cell-degranulation-compared-with-desloratadine-and-levocetirizine-the-maspaf-study
#16
R Munoz-Cano, E Ainsua-Enrich, I Torres-Atencio, M Martin, J Sánchez-Lopez, J Bartra, C Picado, J Mullol, A Valero
BACKGROUND AND OBJECTIVE: Platelet-activating factor (PAF) is a lipid mediator involved in the pathophysiology of several allergic diseases, for example, in the amplification of mast cell (MC) activation in anaphylaxis. Rupatadine is an antihistamine with a demonstrated anti-PAF effect, although its capacity to inhibit PAF-induced MC degranulation has not been fully evaluated. Objectives: To compare the ability of rupatadine to inhibit PAF-induced MC degranulation with that of desloratadine and levocetirizine and to confirm the dual anti-H1 and anti-PAF activity of rupatadine...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28569910/cations-induce-shape-remodeling-of-negatively-charged-phospholipid-membranes
#17
Z T Graber, Z Shi, T Baumgart
The divalent cation Ca(2+) is a key component in many cell signaling and membrane trafficking pathways. Ca(2+) signal transduction commonly occurs through interaction with protein partners. However, in this study we show a novel mechanism by which Ca(2+) may impact membrane structure. We find an asymmetric concentration of Ca(2+) across the membrane triggers deformation of membranes containing negatively charged lipids such as phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2). Membrane invaginations in vesicles were observed forming away from the leaflet with higher Ca(2+) concentration, showing that Ca(2+) induces negative curvature...
June 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28566625/effective-loading-of-platinum-chloroquine-into-pegylated-neutral-and-cationic-liposomes-as-a-drug-delivery-system-for-resistant-malaria-parasites
#18
Shaimaa Ibrahim, Tatsuaki Tagami, Tetsuya Ozeki
The trans platinum-chloroquine diphosphate dichloride (PtCQ) is a new type of antimalarial drug used to fight parasites resistant to traditional drugs. PtCQ is synthesized by mixing platinum and chloroquine diphosphate (CQ). This study examines two efficient methods for forming a nanodrug, PtCQ-loaded liposomes, for use as a potential antimalarial drug-delivery system: the thin drug-lipid film method to incorporate the drug into a liposomal membrane, and a remote-loading method to load the drug into the interior of a cationic liposome...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28566277/enzymatic-lipid-oxidation-by-eosinophils-propagates-coagulation-hemostasis-and-thrombotic-disease
#19
Stefan Uderhardt, Jochen A Ackermann, Tobias Fillep, Victoria J Hammond, Johann Willeit, Peter Santer, Manuel Mayr, Markus Biburger, Meike Miller, Katie R Zellner, Konstantin Stark, Alexander Zarbock, Jan Rossaint, Irene Schubert, Dirk Mielenz, Barbara Dietel, Dorette Raaz-Schrauder, Cihan Ay, Thomas Gremmel, Johannes Thaler, Christian Heim, Martin Herrmann, Peter W Collins, Gernot Schabbauer, Nigel Mackman, David Voehringer, Jerry L Nadler, James J Lee, Steffen Massberg, Manfred Rauh, Stefan Kiechl, Georg Schett, Valerie B O'Donnell, Gerhard Krönke
Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events controlling initiation and propagation of coagulation are still incompletely understood. In this study, we demonstrate an unexpected role of eosinophils during plasmatic coagulation, hemostasis, and thrombosis. Using a large-scale epidemiological approach, we identified eosinophil cationic protein as an independent and predictive risk factor for thrombotic events in humans...
May 31, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28560696/impact-of-the-charge-ratio-on-the-in-vivo-immunogenicity-of-lipoplexes
#20
Zahra Heidari, Jaspreet S Arora, Dibyadyuti Datta, Vijay T John, Nirbhay Kumar, Geetha P Bansal
PURPOSE: The present study investigated the immunogenic potential of different cationic liposome formulations with a DNA plasmid encoding Pfs25, a malaria transmission-blocking vaccine candidate. METHODS: Pfs25 plasmid DNA was complexed with cationic liposomes to produce lipoplexes at different charge ratios of the cationic lipid head group to the nucleotide phosphate (N:P). The formation of lipoplexes was visualized by Cryogenic-TEM. Confocal microscopy of lipoplexes formed with GFP encoding plasmid DNA, and flow cytometry was used to determine their in vitro transfection capability...
May 30, 2017: Pharmaceutical Research
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