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Dina Hafez, Laurence F McMahon, Linda Balogh, Floyd John Brinley, John Crump, Mark Ealovega, Audrey Fan, Yeong Kwok, Kristen Krieger, Thomas O'Connor, Elisa Ostafin, Heidi Reichert, Jennifer Meddings
OBJECTIVES: To characterize patterns of emergency department (ED) utilization for ambulatory care-sensitive conditions (ACSCs) among patients with established care within a patient-centered medical home. STUDY DESIGN: Retrospective chart review using Michigan Medicine's (formerly University of Michigan Health System) electronic health record. METHODS: Ten general medicine (GM) physicians reviewed 256 ambulatory care-sensitive ED encounters that occurred between January 1, 2014, and December 31, 2014, among patients of a GM medical home...
March 1, 2018: American Journal of Managed Care
A Travaglini, S Masieri, C Cavaliere, M A Brighetti
Allergies caused by inhalant allergens, particularly pollens, are steadily increasing in urban centers. It is known that atmospheric pollution is strongly related to the inflammatory disease of the upper and lower airways but it is equally important in the development of sensitization towards pollens. Particulate Matter (PM), sulfur dioxide (SO2) and nitrogen dioxide (NO2) have an enhancement function on the persistence of pollens in the air, increasing the concentration and duration of pollinosis. It is therefore essential to use air quality control methods in urban centers to monitor the presence of pollen and fine dust that can drive the doctor and the patient to improve prevention, a step of primary importance in the treatment of allergies...
January 2018: Journal of Biological Regulators and Homeostatic Agents
Jia Yang, Peng Xiao, Jiaming Sun, Liang Guo
PURPOSE: Melanoma is an aggressive form of human cancer with limited treatment options currently available. The present study was aimed to evaluate the anticancer activity of kaempferol (KAM) against the human malignant melanoma A375 cell line along with evaluation of its effects on apoptosis, cell cycle, cell migration and m-TOR/PI3K/AKT pathway. METHODS: Effects on cell viability were assessed by MTT assay while clonogenic assay measured the effects of KAM on colony formation...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Jianying Shen, Jian Zhou, Yong Lin, Zhen Liu, Ping Chen, Xianchun Wang
Plasma membrane (PM) and mitochondrial membrane (MM) proteins of rat hippocampal neurons were identified and comparatively characterized on the basis of a sequential digestion-centered combinative strategy for sample treatment. A total of 478 membrane proteins were identified, of which 240 had PM localization, 170 had MM localization, and 33 had both of the two subcellular localizations. Compared with the PM proteome, the MM proteome not only was smaller, more basic, and more hydrophobic, but also had a narrower protein molecular mass distribution range and a higher proportion of transmembrane proteins...
March 19, 2018: Analytical and Bioanalytical Chemistry
Jonathan Roth, Haggai Benvenisti, Shlomi Constantini
BACKGROUND: Dural closure following intracranial procedures is considered crucial to reduce postoperative complications such as pseudomeningoceles (PM), CSF leaks, hydrocephalus, and infections. However, watertight dural closure (WTDC) is often difficult to achieve, and dural substitutes are often used. We describe our experience with non-WTDC in children. METHODS: Data was collected retrospectively. Redo and craniectomy cases were excluded. Collected data included demographics, surgical etiology, various radiological parameters, ventricular opening, usage of drains and shunts, dural closure technique, and complications...
March 15, 2018: World Neurosurgery
Dandan Xu, Yi Zhang, Lian Zhou, Tiantian Li
The association between exposure to ambient particulate matter (PM) and reduced lung function parameters has been reported in many works. However, few studies have been conducted in developing countries with high levels of air pollution like China, and little attention has been paid to the acute effects of short-term exposure to air pollution on lung function. The study design consisted of a panel comprising 86 children from the same school in Nanjing, China. Four measurements of lung function were performed...
March 17, 2018: Environmental Science and Pollution Research International
J Hurtado-Gallego, K Martín-Betancor, I Rodea-Palomares, F Leganés, R Rosal, F Fernández-Piñas
This work describes the construction of two novel self-luminescent bioreporter strains of the cyanobacterium Nostoc sp. PCC 7120 by fusing the promoter region of the sodA and sodB genes (encoding the superoxide dismutases MnSod and FeSod, respectively) to luxCDABE from Photorhabdus luminescens aimed at detecting pollutants that generate reactive oxygen species (ROS), particularly O2 - . Bioreporters were tested against methyl viologen (MV) as the inducer of superoxide anion (O2 - ). Both bioreporters were specific for O2 - and Limits of detection (LODs) and Maximum Permissive Concentrations (MPCs) were calculated: Nostoc sp...
March 3, 2018: Chemosphere
Oddvar Myhre, Marit Låg, Gro Villanger, Bente Oftedal, Johan Øvrevik, Jørn A Holme, Heidi Aase, Ragnhild E Paulsen, Anna Bal-Price, Hubert Dirven
Epidemiological studies have demonstrated that air pollution particulate matter (PM) and adsorbed toxicants (organic compounds and trace metals) may affect child development already in utero. Recent studies have also indicated that PM may be a risk factor for neurodevelopmental disorders (NDDs). A pattern of increasing prevalence of attention deficit/hyperactivity disorder (ADHD) has been suggested to partly be linked to environmental pollutants exposure, including PM. Epidemiological studies suggest associations between pre- or postnatal exposure to air pollution components and ADHD symptoms...
March 14, 2018: Toxicology and Applied Pharmacology
Eric Barklis, August O Staubus, Andrew Mack, Logan Harper, Robin Lid Barklis, Ayna Alfadhli
The matrix (MA) domain of the HIV-1 precursor Gag protein (PrGag) has been shown interact with the HIV-1 envelope (Env) protein, and to direct PrGag proteins to plasma membrane (PM) assembly sites by virtue of its affinity to phosphatidylinositol-4,5-bisphosphate (PI[4,5]P2). Unexpectedly, HIV-1 viruses with large MA deletions (ΔMA) have been shown to be conditionally infectious as long as they are matched with Env truncation mutant proteins or alternative viral glycoproteins. To characterize the interactions of wild type (WT) and ΔMA Gag proteins with PI(4,5)P2 and other acidic phospholipids, we have employed a set of lipid biosensors as probes...
March 14, 2018: Virology
Luo Jia-Ying, Chen Zhao, Guo Jia-Jun, Guo Zi-Jun, Lan Xiao, Sun Bao-Qing
BACKGROUND: With the rising prevalence of allergic rhinitis, the utility of indoor environmental management deserves increasing scrutiny. This research aims at evaluating the ability of air purifiers to be a therapy of allergic rhinitis. METHODS: 32 subjects (25±13.5 years old) diagnosed with allergic rhinitis were selected and HEPA air purifiers placed in their bedrooms for 4 months. Before the intervention and each month, dust samples were collected with a vacuum cleaner and the dust collector assessed for allergen content...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
Shaffi Manchanda, Harpal Singh, Taranjeet Kaur, Gurcharan Kaur
Chronic sleep loss/fragmentation prevalent in the current 24/7 society is associated with irreversible consequences on health and overall wellbeing. Various studies have well documented the ill effects of acute sleep loss on cognitive functions of individuals; however, the underlying mechanism behind the chronic sleep loss is yet to be explored. The present study was aimed to investigate whether chronic sleep deprivation (CSD) triggers anxiety-like behaviour and memory decline in male Wistar rats. Rats were sleep deprived by placing them over slowly rotating drum (2 rpm) for 18 h (between 4 pm and 10 am) followed by 6 h of recovery sleep for 21 consecutive days...
March 16, 2018: Molecular and Cellular Biochemistry
Junsheng Yang, Zhuangzhuang Zhao, Mingxue Gu, Xinghua Feng, Haoxing Xu
Cells utilize calcium ions (Ca2+ ) to signal almost all aspects of cellular life, ranging from cell proliferation to cell death, in a spatially and temporally regulated manner. A key aspect of this regulation is the compartmentalization of Ca2+ in various cytoplasmic organelles that act as intracellular Ca2+ stores. Whereas Ca2+ release from the large-volume Ca2+ stores, such as the endoplasmic reticulum (ER) and Golgi apparatus, are preferred for signal transduction, Ca2+ release from the small-volume individual vesicular stores that are dispersed throughout the cell, such as lysosomes, may be more useful in local regulation, such as membrane fusion and individualized vesicular movements...
March 16, 2018: Protein & Cell
Taichi Sakaguchi, Toshinori Totsugawa, Kentaro Tamura, Arudo Hiraoka, Genta Chikazawa, Hidenori Yoshitaka
OBJECTIVE: Despite excellent long-term results reported for a trans-aortic septal myectomy for hypertrophic obstructive cardiomyopathy (HOCM), surgery for patients with diffuse hypertrophy is very challenging. In addition, a left ventricular outflow obstruction is often aggravated by an abnormal mitral valve and subvalvular apparatus. METHODS: We performed video-assisted minimally invasive trans-mitral septal myectomy procedures in 3 patients with diffuse-type HOCM, who were highly symptomatic despite maximal medical therapy...
March 16, 2018: General Thoracic and Cardiovascular Surgery
Guanghui Guo, Bo Song, Deshang Xia, Zijie Yang, Fopeng Wang
Intense mining, smelting, and tailing activities of polymetallic ore deposits have affected the environment in Nandan County, Guangxi, China. Samples of particulates with aerodynamic diameters low or equal 10 μm (PM10 ) were collected in Nandan County to investigate the concentrations of and health risks posed by 17 metals and metalloids in the PM10 . The metal and metalloid concentrations were lower than those found in other industrial cities. The mean Cr concentration was 7.48 ng/m3 . Significant higher metal and metalloid concentrations were found in PM10 from mining areas (Dachang and Chehe) than from the control area (Liuzhai) (p < 0...
March 16, 2018: Environmental Geochemistry and Health
Dong Yan, Tao Zhang, Jing Su, Li-Li Zhao, Hao Wang, Xiao-Mei Fang, Yu-Qin Zhang, Hong-Yu Liu, Li-Yan Yu
The structural variation of the bacterial community associated with particulate matter (PM) was assessed in an urban area of Beijing during haze and non-haze days. Sampling for different PM fractions (PM2.5, PM10, and total suspended particulate) was conducted using three portable air samplers from September 2014 to February 2015. The airborne bacterial community in these samples was analyzed using the Illumina MiSeq platform with bacteria-specific primers targeting the 16S rRNA gene. A total of 1,707,072 reads belonging to 6009 operational taxonomic units were observed...
March 16, 2018: Applied and Environmental Microbiology
Yingshuai Liu, Yunshan Ge, Jianwei Tan, Mingliang Fu, Asad Naeem Shah, Luqiang Li, Zhe Ji, Yan Ding
Maritime transport has been playing a decisive role in global trade. Its contribution to the air pollution of the sea and coastal areas has been widely recognized. The air pollutant emission inventories of several harbors in China have already been established. However, the emission factors of local ships have not been addressed comprehensively, and thus are lacking from the emission inventories. In this study, on-board emission tests of eight diesel-powered offshore fishing ships were conducted near the coastal region of the northern Yellow Bo Sea fishing ground of Dalian, China...
March 2018: Journal of Environmental Sciences (China)
Nicholas Gysel, William A Welch, Chia-Li Chen, Poornima Dixit, David R Cocker, Georgios Karavalakis
This study assessed the effectiveness of three novel control technologies for particulate matter (PM) and volatile organic compound (VOC) removal from commercial meat cooking operations. All experiments were conducted using standardized procedures at University of California, Riverside's commercial test cooking facility. PM mass emissions collected using South Coast Air Quality Management District (SCAQMD) Method 5.1, as well as a dilution tunnel-based PM method showed statistically significantly reductions for each control technology when compared to baseline testing (i...
March 2018: Journal of Environmental Sciences (China)
O V Patsahan, T M Patsahan, M F Holovko
We develop a theory based on the method of collective variables to study the vapor-liquid equilibrium of asymmetric ionic fluids confined in a disordered porous matrix. The approach allows us to formulate the perturbation theory using an extension of the scaled particle theory for a description of a reference system presented as a two-component hard-sphere fluid confined in a hard-sphere matrix. Treating an ionic fluid as a size- and charge-asymmetric primitive model (PM) we derive an explicit expression for the relevant chemical potential of a confined ionic system which takes into account the third-order correlations between ions...
February 2018: Physical Review. E
Robert W Irwin, Jeffrey Smith, S Barry Issenberg
The Accreditation Council for Graduate Medical Education (ACGME) and the American Board of Physical Medicine and Rehabilitation (ABPMR) developed milestones for evaluation of resident physicians that include proper musculoskeletal ultrasound (MSUS) examination of major joints. To date, there have been no published data demonstrating acquisition and retention of these skills and correlation with the milestone evaluation. The investigators developed and implemented a curriculum in musculoskeletal ultrasound examination for Physical Medicine and Rehabilitation (PM&R) residents at a large academic medical center...
March 15, 2018: American Journal of Physical Medicine & Rehabilitation
Dong Dong, Lawrence K F Wong, Zhiwei Luo
By using slide-based task in a laboratory setting, previous studies have found that activation of the rostral prefrontal cortex (BA10) is related to prospective memory performance. In this present study, we used immersive virtual reality (VR) technology to measure PM performance in a real-life task in a simulated virtual environment. Functional near-infrared spectroscopy was used simultaneously to record the rostral prefrontal cortex activities of the subjects. By comparing the data against the ones from the slide-based task, the result suggested that the activation of BA10 in the VR tasks were greater than the one in the slide-based tasks, and the VR tasks have the potential to identify the particular location of BA10 that is connected to the PM performance in our daily lives...
March 16, 2018: Applied Neuropsychology. Adult
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