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https://www.readbyqxmd.com/read/29793105/copd-rat-model-is-more-susceptible-to-cold-stress-and-pm-2-5-exposure-and-the-underlying-mechanism
#1
Kai Zhang, Lei Guo, Qiaozhen Wei, Quanquan Song, Jiangtao Liu, Jingping Niu, Li Zhang, Ye Ruan, Bin Luo
The purpose of this study is to verify the hypothesis that chronic obstructive pulmonary disease (COPD) model rat is more susceptible to cold stress and fine particulate matter (PM2.5 ) exposure than the healthy rat, and explore the related mechanism. COPD rat model, established with cigarette smoke and lipopolysaccharide intratracheal instillation, were exposed to cold stress (0 °C) and PM2.5 (0, 3.2, 12.8 mg/ml). After that, the levels of superoxide dismutase, inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), monocyte chemotactic protein 1 (MCP-1) and angiotensin Ⅱ (Ang-Ⅱ) in lung were measured, as well as the expression levels of lung 8-hydroxy-2-deoxyguanosine (8-OHdG), nuclear factor kappa B (NF-κB), heme-oxygenase-1 (HO-1) and nuclear factor erythroid-2-related factor 2 (Nrf2)...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29792566/clues-to-an-evolutionary-mystery-the-genes-for-t-toxin-enabler-of-the-devastating-1970-southern-corn-leaf-blight-epidemic-are-present-in-ancestral-species-suggesting-an-ancient-origin
#2
Bradford J Condon, Candace E Elliott, Jonathan Gonzalez, Sung-Hwan Yun, Yasunori Akagi, Tyr Wiesner-Hanks, Motoichiro Kodama, Gillian Turgeon
The Southern Corn Leaf Blight epidemic of 1970 devastated fields of T-cytoplasm corn planted in monoculture throughout the eastern US. The epidemic was driven by race T, a previously unseen race of Cochliobolus heterostrophus. A second fungus, Phyllosticta zeae-maydis, with the same biological specificity, appeared coincidentally. Race T produces T-toxin, while P. zeae-maydis produces PM-toxin, both host selective polyketide toxins necessary for supervirulence. Present abundance of genome sequences offers an opportunity to tackle the evolutionary origins of T- and PM- toxin biosynthetic genes, previously thought unique to these species...
May 24, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29792319/a-metal-polydopamine-framework-mpda-as-an-effective-fluorescent-quencher-for-highly-sensitive-detection-of-hg-ii-and-ag-i-ions-through-exonuclease-iii-activity
#3
Ayyanu Ravikumar, Perumal Panneerselvam, Norhashimah Morad
In this paper, we propose a metal-polydopamine framework (MPDA) with specific molecular probe which appears to be the most promising approach to a strong fluorescence quencher. The MPDA framework quenching ability towards various organic fluorophore such as aminoethylcomarin acetate (AMCA), 6-carboxyfluorescein (FAM), carboxyteramethylrhodamine (TAMRA) and Cy5 are used to establish a fluorescent biosensor that can selectively recognize Hg2+ and Ag+ ion. The fluorescent quenching efficiency was sufficient to achieve more than 96%...
May 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29792291/diurnal-variations-of-depression-related-health-information-seeking-case-study-in-finland-using-google-trends-data
#4
Jonas Christoffer Tana, Jyrki Kettunen, Emil Eirola, Heikki Paakkonen
BACKGROUND: Some of the temporal variations and clock-like rhythms that govern several different health-related behaviors can be traced in near real-time with the help of search engine data. This is especially useful when studying phenomena where little or no traditional data exist. One specific area where traditional data are incomplete is the study of diurnal mood variations, or daily changes in individuals' overall mood state in relation to depression-like symptoms. OBJECTIVE: The objective of this exploratory study was to analyze diurnal variations for interest in depression on the Web to discover hourly patterns of depression interest and help seeking...
May 23, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29792222/longevity-and-pleural-mesothelioma-age-period-cohort-analysis-of-incidence-data-from-the-surveillance-epidemiology-and-end-results-seer-program-1973-2013
#5
Brent D Kerger
OBJECTIVE: This study investigates the hypothesis that an increasing fraction of incident pleural mesothelioma (PM) in the US population may be related to longevity, i.e., to expansion of the population over age 75 years with an age-related elevation in risk. An age-period-cohort analysis of the SEER 9 cancer registries (1973-2013) was conducted using 5-year intervals of age, calendar period, and birth cohort after stratification into four gender-age groups (male and female; 0-74 and 75+ years)...
May 23, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29791842/plant-endocytosis-requires-the-er-membrane-anchored-proteins-vap27-1-and-vap27-3
#6
Giovanni Stefano, Luciana Renna, Clarissa Wormsbaecher, Jessie Gamble, Krzysztof Zienkiewicz, Federica Brandizzi
Through yet-undefined mechanisms, the plant endoplasmic reticulum (ER) has a critical role in endocytosis. The plant ER establishes a close association with endosomes and contacts the plasma membrane (PM) at ER-PM contact sites (EPCSs) demarcated by the ER membrane-associated VAMP-associated-proteins (VAP). Here, we investigated two plant VAPs, VAP27-1 and VAP27-3, and found an interaction with clathrin and a requirement for the homeostasis of clathrin dynamics at endocytic membranes and endocytosis. We also demonstrated direct interaction of VAP27-proteins with phosphatidylinositol-phosphate lipids (PIPs) that populate endocytic membranes...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791501/stillbirths-in-urban-guinea-bissau-a-hospital-and-community-based-study
#7
Morten Bjerregaard-Andersen, Najaaraq Lund, Anne Sofie Pinstrup Joergensen, Frida Starup Jepsen, Holger Werner Unger, Mama Mane, Amabelia Rodrigues, Staffan Bergström, Christine Stabell Benn
BACKGROUND: Stillbirth rates remain high in many low-income settings, with fresh (intrapartum) stillbirths accounting for a large part due to limited obstetrical care. We aimed to determine the stillbirth rate and identify potentially modifiable factors associated with stillbirth in urban Guinea-Bissau. METHODS: The study was carried out by the Bandim Health Project (BHP), a Health and Demographic Surveillance System site in the capital Bissau. We assessed stillbirth rates in a hospital cohort consisting of all deliveries at the maternity ward at the National Hospital Simão Mendes (HNSM), and in a community cohort, which only included women from the BHP area...
2018: PloS One
https://www.readbyqxmd.com/read/29791400/temperature-independent-hygrometry-using-micromachined-photonic-crystal-fiber
#8
Pan Zhang, Hangzhou Yang, Kok-Sing Lim, Harith Ahmad, Qiangzhou Rong, Qin Tian, Xiangzi Ding
An in-fiber Mach-Zehnder interferometer (MZI) is proposed and experimentally demonstrated for relative humidity (RH) and temperature measurements. The MZI is formed by a grapefruit-shaped photonic crystal fiber (G-PCF) cascaded with a short section of multimode fiber that serves as a mode coupler. To enhance sensitivity to humidity, femtosecond laser micromachining was performed to remove a portion of cladding of the G-PCF to expose its core to the ambient medium. The output interference spectrum is fast Fourier transformed to produce a spatial frequency spectrum that describes the intensity composition of the cladding modes in the MZI...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791319/malignancy-in-a-retrospective-cohort-of-17-patients-with-dermatomyositis-or-polymyositis-in-southern-tunisia
#9
Khadija Sellami, Madiha Mseddi, Mouna Snoussi, Hela Gharbi, Faten Frikha, Rayda Ben Salah, Moez Jallouli, Sameh Marzouk, Abderrahmen Masmoudi, Zouhir Bahloul, Hamida Turki
INTRODUCTION: The prognosis of dermatomyositis (DM)/polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. METHODS: A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015...
May 21, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29790979/petrosal-meningiomas-factors-affecting-outcome-and-the-role-of-intraoperative-multimodal-assistance-to-microsurgery
#10
Francesco Tomasello, Filippo Flavio Angileri, Alfredo Conti, Antonino Scibilia, Salvatore Cardali, Domenico La Torre, Antonino Germanò
BACKGROUND: Petrous meningiomas (PMs) represent a subset of posterior fossa tumors accounting for ∼8% of all intracranial meningiomas. Surgical treatment of PMs is challenging because of their relationships with vital neurovascular structures of the cerebellopontine angle. OBJECTIVE: To investigate independent pre- and intraoperative predictors of PM surgery outcome. METHODS: We reviewed the surgical and outcome data of patients who underwent microsurgical resection of PMs from 1997 to 2016...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29790734/palladium-supported-on-amphiphilic-triazine-urea-functionalized-porous-organic-polymer-as-highly-efficient-electrocatalyst-for-electrochemical-sensing-of-rutin-in-human-plasma
#11
A T Ezhil Vilian, Rajamanickam Sivakumar, Yun Suk Huh, Ji Ho Youk, Young-Kyu Han
Metal nanoparticle-containing porous organic polymers have gained great interest in chemical and pharmaceutical applications owing to their high reactivity and good recyclability. In the present work, a palladium nanoparticle-decorated triazine-urea-based porous organic polymer (Pd@TU-POP) was designed and synthesized using 1, 3-bis (4-aminiphenyl) urea with cyanuric chloride and palladium acetate. The porous structure and physicochemical properties of this electrode material Pd@TU-POP were observed using a range of standard techniques...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790224/left-atrial-compression-and-right-ventricular-outflow-tract-diameter-on-echocardiography-are-independently-associated-with-exercise-capacity-in-patients-with-large-hiatal-hernia
#12
Christopher Naoum, Leonard Kritharides, Gregory L Falk, David Martin, John Yiannikas
INTRODUCTION: Large hiatal hernia (HH) is often associated with left atrial (LA) compression, anteroposterior cardiac compression (manifesting as reduced right ventricular outflow tract (RVOT) diameter), and left ventricular (LV) compression (manifesting as systolic paradoxical outward motion (LV-PM) of the posterobasal LV segment). Exercise impairment, also common in this population, improves following HH surgery. We aimed to identify echocardiographic parameters independently associated with exercise impairment due to HH-mediated cardiogenic compression...
May 2018: Echocardiography
https://www.readbyqxmd.com/read/29790185/a-combined-epicardial-implantation-and-subsequent-extraction-strategy-in-pacemaker-device-infection-in-pacemaker-dependent-patients
#13
Floris S van den Brink, Vincent F van Dijk, Lucas Va Boersma, Maurtis Cef Wijffels, John Gelissen, Edgar Daeter, Uday Sonker, Jippe Balt
INTRODUCTION: Treatment of pacemaker (PM) device infections is challenging in pacemaker dependent patients. We propose a novel implantation strategy for this group of patients. METHODS: Patients who were PM dependent and were admitted with a PM infection received a combined procedure of LV epicardial implantation of a PM lead and subsequent extraction of the infected system. No temporary pacing wire was used and the PM generator was placed in the left flank. RESULTS: Between 2012 and 2015 we treated 16 patients who were PM dependent with a PM infection...
May 23, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29789490/evaluation-of-lactic-acid-bacteria-on-the-inhibition-of-vibrio-parahaemolyticus-infection-and-its-application-to-food-systems
#14
Cheng-Chih Tsai, Yung-Hsien Hung, Lan-Chun Chou
This study tested the effect of lactic acid bacteria (LAB) inhibition on Vibrio parahaemolyticus BCRC (Bioresource Collection and Research Center) 10806 and BCRC 12865 in a food model. MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays indicated that Caco-2 cells were not damaged after a two-hour treatment with lactic acid bacteria (LAB) and V. parahaemolyticus . The LAB cell culture and supernatant effectively inhibited the growth of V. parahaemolyticus in a food model. ELISA (Enzyme-linked immunosorbent assay) results indicated the significant inhibition of TNF-α; IL-1β; and IL-6; but Lactobacillus plantarum PM 222 and L...
May 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29789424/the-c-terminal-region-of-the-yeast-monocarboxylate-transporter-jen1-acts-as-a-glucose-signal-responding-degron-recognized-by-the-%C3%AE-arrestin-rod1
#15
Shoki Fujita, Daichi Sato, Hirokazu Kasai, Masataka Ohashi, Shintaro Tsukue, Yutaro Takekoshi, Katsuya Gomi, Takahiro Shintani
In response to changes in nutrient conditions, cells rearrange the composition of plasma membrane (PM) transporters to optimize their metabolic flux. Not only transcriptional gene regulation, but also inactivation of specific transporters is important for fast rearrangement of the PM. In eukaryotic cells, endocytosis plays a role in transporter inactivation, which is triggered by ubiquitination of these transporters. The Nedd4 family E3 ubiquitin ligase is responsible for ubiquitination of the PM transporters and requires that a series of α-arrestin proteins are targeted to these transporters...
May 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29787974/using-big-data-from-air-quality-monitors-to-evaluate-indoor-pm-2-5-exposure-in-buildings-case-study-in-beijing
#16
JinXing Zuo, Wei Ji, YuJie Ben, Muhammad Azher Hassan, WenHong Fan, Liam Bates, ZhaoMin Dong
Due to time- and expense- consuming of conventional indoor PM2.5 (particulate matter with aerodynamic diameter of less than 2.5 μm) sampling, the sample size in previous studies was generally small, which leaded to high heterogeneity in indoor PM2.5 exposure assessment. Based on 4403 indoor air monitors in Beijing, this study evaluated indoor PM2.5 exposure from 15th March 2016 to 14th March 2017. Indoor PM2.5 concentration in Beijing was estimated to be 38.6 ± 18.4 μg/m3 . Specifically, the concentration in non-heating season was 34...
May 19, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29787925/the-association-between-perceived-distress-tolerance-and-cannabis-use-problems-cannabis-withdrawal-symptoms-and-self-efficacy-for-quitting-cannabis-the-explanatory-role-of-pain-related-affective-distress
#17
Kara Manning, Andrew H Rogers, Jafar Bakhshaie, Julianna B D Hogan, Julia D Buckner, Joseph W Ditre, Michael J Zvolensky
Rates of cannabis use and related problems continue to rise, ranking as the third most common substance use disorder in the United States, behind tobacco and alcohol use. Past work suggests that perceived distress tolerance is related to several clinically significant features of cannabis use (e.g., coping-oriented use). However, there has been little exploration of the mechanisms that may underlie relations between perceived distress tolerance and cannabis use problems, withdrawal severity, and self-efficacy for quitting...
May 19, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29787898/long-term-effects-of-air-pollution-on-ankle-brachial-index
#18
Siqi Zhang, Kathrin Wolf, Susanne Breitner, Florian Kronenberg, Massimo Stafoggia, Annette Peters, Alexandra Schneider
BACKGROUND: Ankle-brachial index (ABI) has been linked to the risk of cardiovascular events. However, the association between long-term exposure to air pollution and abnormal ABI has not been fully investigated. METHODS: This cross-sectional study involved 4544 participants from the KORA Study (2004-2008) in the region of Augsburg, Germany. Participants' residential annual mean concentrations of particulate matter (PM) and nitrogen dioxide (NO2 ) were predicted with land-use regression models, and the traffic information was collected from geographic information systems...
May 19, 2018: Environment International
https://www.readbyqxmd.com/read/29787794/early-growth-response-gene-1-is-essential-for-urban-particulate-matter-induced-inflammation-and-mucus-hyperproduction-in-airway-epithelium
#19
Feng Xu, Jiaofei Cao, Man Luo, Luanqing Che, Wen Li, Songmin Ying, Zhihua Chen, Huahao Shen
Particulate matter (PM) has been implicated as a risk factor for human airway disorders. However, the biological mechanisms underlying the correlation between PM exposure and adverse airway effects have not yet been fully clarified. The objective of this study was to explore the possible role of early growth response gene 1 (Egr-1) in PM-induced toxic effects in pulmonary inflammation and mucus hyperproduction in vitro and in vivo. Particulate matter exposure induced a rapid Egr-1 expression in human bronchial epithelial (HBE) cells and in mouse lungs...
May 19, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29787701/the-effect-of-sleep-quality-on-academic-performance-is-mediated-by-internet-use-time-dados-study
#20
Mireia Adelantado-Renau, Ana Diez-Fernandez, Maria Reyes Beltran-Valls, Alberto Soriano-Maldonado, Diego Moliner-Urdiales
OBJECTIVE: The aims of the present study were to analyze the association of sleep patterns with academic and cognitive performance in adolescents, and to test the potential mediating effect of different activities of screen media usage on this association. METHODS: A sample of 269 adolescents (140 boys) aged 14 years from the baseline data of the DADOS (Deporte, ADOlescencia y Salud). Study completed questionnaires about sleep quality, cognitive performance, and leisure-time sedentary behaviors...
May 19, 2018: Jornal de Pediatria
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