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https://www.readbyqxmd.com/read/28545241/lactobacillus-rhamnosus-hn001-and-lactobacillus-acidophilus-la-14-attenuate-gardnerella-vaginalis-infected-bacterial-vaginosis-in-mice
#1
Se-Eun Jang, Jin-Ju Jeong, Su-Young Choi, Hyunji Kim, Myung Joo Han, Dong-Hyun Kim
Oral administration of a probiotic mixture (PM; Respecta(®)) consisting of Lactobacillus rhamnosus HN001 (L1), Lactobacillus acidophilus La-14 (L2), and lactoferrin RCXTM results in colonization of these probiotics in the vagina of healthy women. Therefore, we examined whether vaginal colonization of the PM ingredients L1 and L2 could attenuate bacterial vaginosis (BV). BV was induced in mice via β-estradiol-3-benzoate-induced immunosuppression and intravaginal inoculation with Gardnerella vaginalis (GV)...
May 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28545235/a-high-sensitive-pressure-sensor-using-a-single-mode-fiber-embedded-microbubble-with-thin-film-characteristics
#2
Guanjun Wang, Xinglin Liu, Zhiguo Gui, Yongquan An, Jinyu Gu, Meiqin Zhang, Lu Yan, Gao Wang, Zhibin Wang
A new fiber pressure sensor is proposed and analyzed in this paper. A commercial arc fusion splicer and pressure-assisted arc discharge technology are used here to fabricate a silica hollow microbubble from a common glass tube with the characteristics of a thin film. Then the single mode fiber is embedded into the microbubble to form a fiber Fabry-Perot interferometer by measuring the reflected interference spectrum from the fiber tip and microbubble end. As the wall thickness of the micro-bubble can reach up to several micrometers, it can then be used for measuring the outer pressure with high sensitivity...
May 23, 2017: Sensors
https://www.readbyqxmd.com/read/28544980/what-we-authors-reviewers-and-editors-of-scientific-work-can-learn-from-the-analytical-history-of-biological-3-nitrotyrosine
#3
REVIEW
Dimitrios Tsikas
Tyrosine and tyrosine residues in proteins are attacked by the reactive oxygen and nitrogen species peroxynitrite (O=N-OO(-)) to generate 3-nitrotyrosine (3-NT) and 3-nitrotyrosine-proteins (3-NTProt), respectively. 3-NT and 3-NTProt are widely accepted as biomarkers of nitr(os)ative stress. Over the years many different analytical methods have been reported for 3-NT and 3-NTProt. Reported concentrations often differ by more than three orders of magnitude, indicative of serious analytical problems. Strategies to overcome pre-analytical and analytical shortcomings and pitfalls have been proposed...
May 13, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28544897/size-resolved-aerosol-water-soluble-ions-during-the-summer-and-winter-seasons-in-beijing-formation-mechanisms-of-secondary-inorganic-aerosols
#4
Zirui Liu, Yuzhu Xie, Bo Hu, Tianxue Wen, Jinyuan Xin, Xingru Li, Yuesi Wang
Size-segregated water-soluble ionic species (WSIs) were measured using an Anderson cascade impactor from Jul. to Aug. 2008 and from Dec. 2009 to Feb. 2010 in urban Beijing. The results showed that fine particles (PM2.1, Dp < 2.1 μm) accounted for ∼49% (summer) and ∼34% (winter) of the total particulate mass, and WSIs accounted for 23-82% of the mass concentration of PM2.1. Secondary inorganic aerosols (SIAs, the sum of SO4(2-), NO3(-) and NH4(+)) accounted for more than 30% of the fine particles, which were greatly elevated during particle pollution events (PM events), thereby leading to an alteration of the size distributions of SO4(2-) and NO3(-) to nearly single fine-mode distributions peaking at 0...
May 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28544259/periodontal-maintenance-following-active-specialist-treatment-should-patients-stay-put-or-return-to-primary-dental-care-for-continuing-care-a-comparison-of-outcomes-based-on-the-literature
#5
REVIEW
P G Leavy, D P Robertson
OBJECTIVES: To review the evidence for the efficacy of periodontal maintenance (PM) carried out in primary dental care (PDC) compared to the specialist setting for patients previously treated in a specialist setting for chronic (ChP) or aggressive (AgP) periodontitis. METHODS: A focused PICO question and search protocol were developed. Online databases including MEDLINE, EMBASE, WEB OF SCIENCE™ and COCHRANE LIBRARY were searched along with specialist journals in the subject area of periodontal research...
May 22, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28542459/identification-and-evaluation-of-resistance-to-powdery-mildew-and-yellow-rust-in-a-wheat-mapping-population
#6
Lijun Yang, Xuejiang Zhang, Xu Zhang, Jirui Wang, Mingcheng Luo, Mujun Yang, Hua Wang, Libo Xiang, Fansong Zeng, Dazhao Yu, Daolin Fu, Garry M Rosewarne
Deployment of cultivars with genetic resistance is an effective approach to control the diseases of powdery mildew (PM) and yellow rust (YR). Chinese wheat cultivar XK0106 exhibits high levels of resistance to both diseases, while cultivar E07901 has partial, adult plant resistance (APR). The aim of this study was to map resistance loci derived from the two cultivars and analyze their effects against PM and YR in a range of environments. A doubled haploid population (388 lines) was used to develop a framework map consisting of 117 SSR markers, while a much higher density map using the 90K Illumina iSelect SNP array was produced with a subset of 80 randomly selected lines...
2017: PloS One
https://www.readbyqxmd.com/read/28542094/virtual-monoenergetic-imaging-and-iodine-perfusion-maps-improve-diagnostic-accuracy-of-dual-energy-computed-tomography-pulmonary-angiography-with-suboptimal-contrast-attenuation
#7
Doris Leithner, Julian L Wichmann, Thomas J Vogl, Jesko Trommer, Simon S Martin, Jan-Erik Scholtz, Boris Bodelle, Carlo N De Cecco, Taylor Duguay, John W Nance, U Joseph Schoepf, Moritz H Albrecht
OBJECTIVES: The aim of this study was to investigate the impact of virtual monoenergetic imaging (VMI+) and dual-energy computed tomography perfusion maps (DECT-PMs) on reader confidence and diagnostic accuracy in dual-energy computed tomography pulmonary angiography (DE-CTPA) studies with suboptimal contrast attenuation, compared with standard linearly blended reconstruction series. MATERIALS AND METHODS: Dual-energy computed tomography pulmonary angiography examinations with suboptimal contrast attenuation of 68 patients with suspected pulmonary embolism (PE) were included in this institutional review board-approved retrospective study...
May 24, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28541679/biomagnetic-monitoring-of-atmospheric-pollution-a-review-of-magnetic-signatures-from-biological-sensors
#8
Jelle Hofman, Barbara A Maher, Adrian R Muxworthy, Karen Wuyts, Ana Castanheiro, Roeland Samson
Biomagnetic monitoring of atmospheric pollution is a growing application in the field of environmental magnetism. Particulate matter (PM) in atmospheric pollution contains readily-measurable concentrations of magnetic minerals. Biological surfaces, exposed to atmospheric pollution, accumulate magnetic particles over time, providing a record of location-specific, time-integrated air quality information. This review summarizes current knowledge of biological material ('sensors') used for biomagnetic monitoring purposes...
May 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28541501/satellite-based-estimates-of-long-term-exposure-to-fine-particulate-matter-are-associated-with-c-reactive-protein-in-30%C3%A2-034-taiwanese-adults
#9
Zilong Zhang, Ly-Yun Chang, Alexis K H Lau, Ta-Chien Chan, Yuan Chieh Chuang, Jimmy Chan, Changqing Lin, Wun Kai Jiang, Keith Dear, Benny C Y Zee, Eng-Kiong Yeoh, Gerard Hoek, Tony Tam, Xiang Qian Lao
Background: Particulate matter (PM) air pollution is associated with the risk of cardiovascular morbidity and mortality. However, the biological mechanism underlying the associations remains unclear. Atherosclerosis, the underlying pathology of cardiovascular disease, is a chronic inflammatory process. We therefore investigated the association of long-term exposure to fine PM (PM 2.5 ) with C-reactive protein (CRP), a sensitive marker of systemic inflammation, in a large Taiwanese population...
May 25, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28540831/ninety-percent-of-the-adverse-outcomes-occur-in-ten-percent-of-patients-can-we-identify-the-populations-at-high-risk-of-developing-peritoneal-metastases-after-curative-surgery-for-colorectal-cancer
#10
Charles Honoré, Maximiliano Gelli, Julie Francoual, Léonor Benhaim, Dominique Elias, Diane Goéré
BACKGROUND: Peritoneal metastases (PM) occur in 3.4% to 6.3% after curative surgery for non-metastatic colorectal cancer. Systematic "2(nd) look" surgery help overcoming the diagnostic problem but can be only proposed to selected patients. The aim of this study was to update the knowledge on risk factors of developing PM after curative surgery for colorectal cancer. METHODS: A systematic review of the literature published between 2011 and 2016 was made, searching for all clinical studies reporting the incidence of recurrent PM after curative surgery for colorectal cancer and factors associated with the primary tumor that were likely to influence this recurrence rate...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540827/complete-cytoreductive-surgery-plus-hipec-for-peritoneal-metastases-from-unusual-cancer-sites-of-origin-results-from-a-worldwide-analysis-issue-of-the-peritoneal-surface-oncology-group-international-psogi
#11
Diane Goéré, Guillaume Passot, Maximiliano Gelli, Edward A Levine, David L Bartlett, Paul H Sugarbaker, Olivier Glehen
AIM: The aim of this study was to assess the outcomes of patients operated on for peritoneal metastases from unusual cancer sites of origin, meaning apart from PM from colorectal, gastric and epithelial ovarian carcinomas, pseudomyxoma peritonei and mesothelioma. PATIENTS AND METHODS: A questionnaire concerning patients treated with CRS plus HIPEC for PM arising from unusual cancer sites of origin was sent to all centers that routinely performed HIPEC, through the Peritoneal Surface Oncology Group International and the RENAPE network...
March 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540812/galectin-1-based-tumour-targeting-for-gold-nanostructure-mediated-photothermal-therapy
#12
Samir V Jenkins, Dmitry A Nedosekin, Emily K Miller, Vladimir P Zharov, Ruud P M Dings, Jingyi Chen, Robert J Griffin
PURPOSE: To demonstrate delivery of Au nanocages to cells using the galectin-1 binding peptide anginex (Ax) and to demonstrate the value of this targeting for selective in vitro photothermal cell killing. MATERIALS AND METHODS: Au nanocages were synthesised, coated with polydopamine (PDA), and conjugated with Ax. Tumour and endothelial cell viability was measured with and without laser irradiation. Photoacoustic (PA) mapping and PA flow cytometry were used to confirm cell targeting in vitro and in tissue slices ex vivo...
May 9, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540736/effects-of-diesel-exhaust-on-cardiovascular-function-and-oxidative-stress
#13
Simon Wilson, Mark R Miller, David E Newby
SIGNIFICANCE: Air pollution is a major global health concern with the particulate matter (PM) being especially associated with marked increases in cardiovascular morbidity and mortality. Diesel exhaust emissions are a particularly rich source of the smallest sizes of PM ("fine" and "ultrafine") in urban environments, and it is these particles that are believed to be the most detrimental to cardiovascular health. Recent Advances: Controlled exposure studies to diesel exhaust in animals and man demonstrate alterations in blood pressure, heart rate, vascular tone, endothelial function, myocardial perfusion, thrombosis, atherogenesis and plaque stability...
May 25, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28540724/pde%C3%AE-binding-to-ras-isoforms-provides-a-route-to-proper-membrane-localization
#14
Serena Muratcioglu, Hyunbum Jang, Attila Gursoy, Ozlem Keskin, Ruth Nussinov
To signal, Ras isoforms must be enriched at the plasma membrane (PM). It was suggested that phosphodiesterase-δ (PDEδ) can bind and shuttle some farnesylated Ras isoforms to the PM - but not all. Among these, interest focused on K-Ras4B, the most abundant oncogenic Ras isoform. To study PDEδ/Ras interactions, we modeled and simulated the PDEδ/K-Ras4B complex. We obtained structures which were similar to two subsequently determined crystal structures. We next modeled and simulated complexes of PDEδ with the farnesylated hypervariable regions (HVRs) of K-Ras4A and N-Ras...
May 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28539604/prostaglandin-e2-glyceryl-ester-is-an-endogenous-agonist-of-the-nucleotide-receptor-p2y6
#15
Antje Brüser, Anne Zimmermann, Brenda C Crews, Gregory Sliwoski, Jens Meiler, Gabriele M König, Evi Kostenis, Vera Lede, Lawrence J Marnett, Torsten Schöneberg
Cyclooxygenase-2 catalyses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol. Previous studies identified PG-Gs as signalling molecules involved in inflammation. Thus, the glyceryl ester of prostaglandin E2, PGE2-G, mobilizes Ca(2+) and activates protein kinase C and ERK, suggesting the involvement of a G protein-coupled receptor (GPCR). To identify the endogenous receptor for PGE2-G, we performed a subtractive screening approach where mRNA from PGE2-G response-positive and -negative cell lines was subjected to transcriptome-wide RNA sequencing analysis...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539409/spatial-analysis-of-cdc42-activity-reveals-a-role-for-plasma-membrane-associated-cdc42-in-centrosome-regulation
#16
Kari A Herrington, Andrew L Trinh, Carolyn Dang, Ellen O'Shaughnessy, Klaus M Hahn, Enrico Gratton, Michelle A Digman, Christine Sütterlin
The ability of the small GTPase Cdc42 to regulate diverse cellular processes depends on tight spatial control of its activity. Cdc42 function is best understood at the plasma membrane (PM), where it regulates cytoskeletal organization and cell polarization. Active Cdc42 has also been detected at the Golgi, but its role and regulation at this organelle is only partially understood. Here we analyze the spatial distribution of Cdc42 activity by monitoring the dynamics of the Cdc42 FLARE biosensor using the phasor approach to FLIM-FRET...
May 24, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28538762/papillary-muscle-free-strain-in-patients-with-severe-degenerative-and-functional-mitral-regurgitation
#17
Alev Kılıcgedik, Gokhan Kahveci, Ahmet Seyfeddin Gurbuz, Can Yucel Karabay, Ahmet Guler, Suleyman Cagan Efe, Soe Moe Aung, Ugur Arslantas, Serdar Demir, Ibrahim Akin Izgi, Cevat Kirma
Fundamento: The role of papillary muscle function in severe mitral regurgitation with preserved and reduced left ventricular ejection fraction and the method of choice to evaluate PM have still been the subjects of controversy. Objectives: To evaluate and compare papillary muscle function in and between patients with severe degenerative and functional mitral regurgitation by using the free strain method. Methods: 64 patients with severe mitral regurgitation - 39 patients with degenerative mitral regurgitation (DMR group) and 25 patients with severe functional mitral regurgitation (FMR group) - and 30 control subjects (control group) were included in the study...
April 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28537223/structural-evolution-behavior-of-manganese-monophosphide-under-high-pressure-experimental-and-theoretical-study
#18
Zhenhai Yu, Wei Wu, Pengchao Lu, Jinggeng Zhao, Jinguang Cheng, Qingyang Hu, Ye Yuan, Xin Li, Cuiying Pei, Fengjiao Chen, Zhipeng Yan, Shuai Yan, Ke Yang, Jian Sun, Jianlin Luo, Lin Wang
The influence of external pressure on the structural properties of manganese monophosphides (MnP) at room temperature has been studied using in situ angle dispersive synchrotron x-ray powder diffraction (AD-XRD) with a diamond anvil cell. The crystal structure of MnP is stable between 0 to 15 GPa. However, the compressibility of b-axis is much larger than those of a- and c-axes. From this result we suggested that the occurrence of superconductivity in MnP was induced by suppression of the long-range antiferromagnetically ordered state rather than a structural phase transition...
May 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28537024/absolute-configuration-of-2-2-3-3-6-pentachlorinatedbiphenyl-pcb-84-atropisomers
#19
Xueshu Li, Sean R Parkin, Hans-Joachim Lehmler
Nineteen polychlorinated biphenyl (PCB) congeners, such as 2,2',3,3',6-pentachlorobiphenyl (PCB 84), display axial chirality because they form stable rotational isomers, or atropisomers, that are non-superimposable mirror images of each other. Although chiral PCBs undergo atropselective biotransformation and atropselectively alter biological processes, the absolute structure of only a few PCB atropisomers has been determined experimentally. To help close this knowledge gap, pure PCB 84 atropisomers were obtained by semi-preparative liquid chromatography with two serially connected Nucleodex β-PM columns...
May 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28536350/nano-magnetic-resonance-imaging-nano-mri-gives-personalized-medicine-a-new-perspective
#20
Lorenzo Rosa, Jonathan Blackledge, Albert Boretti
This paper reviews some of the major and most recent advances in nanoscale-magnetic resonance imaging (nano-MRI) for personalized medicine (PM). Nano-MRI may drastically expand the capabilities of the traditional magnetic resonance images (MRI), down to the nanometer scale and possibly, in the near future, at the atomic scale. Nano-MRI is potentially able to observe structures which cannot be seen using today's molecular imaging, with sensitivities of many billions of times better than MRI as currently used in hospitals, for example...
February 1, 2017: Biomedicines
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