keyword
MENU ▼
Read by QxMD icon Read
search

marine toxins

keyword
https://www.readbyqxmd.com/read/28443076/rstb-regulates-expression-of-the-photobacterium-damselae-subsp-damselae-major-virulence-factors-damselysin-phobalysin-p-and-phobalysin-c
#1
Mateus S Terceti, Amable J Rivas, Laura Alvarez, Manuel Noia, Felipe Cava, Carlos R Osorio
The marine pathogenic bacterium Photobacterium damselae subsp. damselae causes septicemia in marine animals and in humans. The pPHDD1 plasmid-encoded hemolysins damselysin (Dly) and phobalysin P (PhlyP), and the chromosome-encoded hemolysin phobalysin C (PhlyC) constitute its main virulence factors. However, the mechanisms by which expression of these three hemolysins is regulated remain unknown. Here we report the isolation of a mini-Tn10 transposon mutant which showed a strong impairment in its hemolytic activity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28437727/new-inter-correlated-genes-targeted-by-diatom-derived-polyunsaturated-aldehydes-in-the-sea-urchin-paracentrotus-lividus
#2
Nadia Ruocco, Anna Maria Fedele, Susan Costantini, Giovanna Romano, Adrianna Ianora, Maria Costantini
The marine environment is continually subjected to the action of stressors (including natural toxins), which represent a constant danger for benthic communities. In the present work using network analysis we identified ten genes on the basis of associated functions (FOXA, FoxG, GFI-1, nodal, JNK, OneCut/Hnf6, TAK1, tcf4, TCF7, VEGF) in the sea urchin Paracentrotus lividus, having key roles in different processes, such as embryonic development and asymmetry, cell fate specification, cell differentiation and morphogenesis, and skeletogenesis...
April 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28429183/label-free-okadaic-acid-detection-using-growth-of-gold-nanoparticles-in-sensor-gaps-as-a-conductive-tag
#3
Yuxiang Pan, Zijian Wan, Longjie Zhong, Xueqin Li, Qi Wu, Jun Wang, Ping Wang
Okadaic acid (OA) is a marine toxin ingested by shellfish. In this work, a simple, sensitive and label-free gap-based electrical competitive bioassay has been developed for this biotoxin detection. The gap-electrical biosensor is constructed by modifying interdigitated microelectrodes with gold nanoparticles (AuNPs) and using the self-catalytic growth of AuNPs as conductive bridges. In this development, the AuNPs growth is realized in the solution of glucose and chloroauric acid, with glucose oxidation used as the catalysis for growth of the AuNPs...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28427570/high-resolution-mass-spectrometry-based-screening-reveals-lipophilic-toxins-in-multiple-trophic-levels-from-the-north-sea
#4
Gabriel Orellana, Lieven Van Meulebroek, Maarten De Rijcke, Colin R Janssen, Lynn Vanhaecke
Lipophilic marine biotoxins, which are mainly produced by small dinoflagellates, are increasingly detected in coastal waters across the globe. As these producers are consumed by zooplankton and shellfish, the toxins are introduced, bioaccumulated and possibly biomagnified throughout marine food chains. Recent research has demonstrated that ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) is an excellent tool to detect marine toxins in algae and seafood. In this study, UHPLC-HRMS was used to screen lipophilic marine biotoxins in organisms from different trophic levels of the Belgian coastal zone ecosystem...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28427569/chronic-low-level-exposure-to-the-common-seafood-toxin-domoic-acid-causes-cognitive-deficits-in-mice
#5
Kathi A Lefebvre, Preston S Kendrick, Warren Ladiges, Emma M Hiolski, Bridget E Ferriss, Donald R Smith, David J Marcinek
The consumption of one meal of seafood containing domoic acid (DA) at levels high enough to induce seizures can cause gross histopathological lesions in hippocampal regions of the brain and permanent memory loss in humans and marine mammals. Seafood regulatory limits have been set at 20mgDA/kg shellfish to protect human consumers from symptomatic acute exposure, but the effects of repetitive low-level asymptomatic exposure remain a critical knowledge gap. Recreational and Tribal-subsistence shellfish harvesters are known to regularly consume low levels of DA...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28409150/mitotic-catastrophe-in-bc3h1-cells-following-yessotoxin-exposure
#6
Mónica Suárez Korsnes, Reinert Korsnes
The marine toxin yessotoxin (YTX) can cause various cytotoxic effects depending on cell type and cell line. It is well known to trigger distinct mechanisms for programmed cell death which may overlap or cross-talk. The present contribution provides the first evidence that YTX can cause genotoxicity and induce mitotic catastrophe which can lead to different types of cell death. This work also demonstrates potential information gain from non-intrusive computer-based tracking of many individual cells during long time...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28396446/identification-of-a-cono-rfamide-from-the-venom-of-conus-textile-that-targets-asic3-and-enhances-muscle-pain
#7
Catharina Reimers, Cheng-Han Lee, Hubert Kalbacher, Yuemin Tian, Chih-Hsien Hung, Axel Schmidt, Lea Prokop, Silke Kauferstein, Dietrich Mebs, Chih-Cheng Chen, Stefan Gründer
Acid-sensing ion channels (ASICs) are proton-gated Na(+) channels that are expressed throughout the nervous system. ASICs have been implicated in several neuronal disorders, like ischemic stroke, neuronal inflammation, and pathological pain. Several toxins from venomous animals have been identified that target ASICs with high specificity and potency. These toxins are extremely useful in providing protein pharmacophores and to characterize function and structure of ASICs. Marine cone snails contain a high diversity of toxins in their venom such as conotoxins, which are short polypeptides stabilized by disulfide bonds, and conopeptides, which have no or only one disulfide bond...
April 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28388672/toxicity-of-benthic-dinoflagellates-on-grazing-behavior-and-survival-of-the-brine-shrimp-artemia-salina
#8
Raquel A F Neves, Tainá Fernandes, Luciano Neves Dos Santos, Silvia M Nascimento
Harmful algae may differently affect their primary grazers, causing sub-lethal effects and/or leading to their death. The present study aim to compare the effects of three toxic benthic dinoflagellates on clearance and grazing rates, behavioral changes, and survival of Artemia salina. Feeding assays consisted in 1-h incubations of brine shrimps with the toxic Prorocentrum lima, Gambierdiscus excentricus and Ostreopsis cf. ovata and the non-toxic Tetraselmis sp. Brine shrimps fed unselectively on all toxic and non-toxic algal preys, without significant differences in clearance and ingestion rates...
2017: PloS One
https://www.readbyqxmd.com/read/28379705/karmitoxin-an-amine-containing-polyhydroxy-polyene-toxin-from-the-marine-dinoflagellate-karlodinium-armiger
#9
Silas Anselm Rasmussen, Sofie Bjørnholt Binzer, Casper Hoeck, Sebastian Meier, Livia Soman de Medeiros, Nikolaj Gedsted Andersen, Allen Place, Kristian Fog Nielsen, Per Juel Hansen, Thomas Ostenfeld Larsen
Marine algae from the genus Karlodinium are known to be involved in fish-killing events worldwide. Here we report for the first time the chemistry and bioactivity of a natural product from the newly described mixotrophic dinoflagellate Karlodinium armiger. Our work describes the isolation and structural characterization of a new polyhydroxy-polyene named karmitoxin. The structure elucidation work was facilitated by use of (13)C enrichment and high-field 2D NMR spectroscopy, where (1)H-(13)C long-range correlations turned out to be very informative...
April 5, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28366392/toxicity-screening-of-13-gambierdiscus-strains-using-neuro-2a-and-erythrocyte-lysis-bioassays
#10
Francesco Pisapia, William C Holland, D Ransom Hardison, R Wayne Litaker, Santiago Fraga, Tomohiro Nishimura, Masao Adachi, Lam Nguyen-Ngoc, Véronique Séchet, Zouher Amzil, Christine Herrenknecht, Philipp Hess
Species in the epi-benthic dinoflagellate genus Gambierdiscus produce ciguatoxins (CTXs) and maitotoxins (MTXs), which are among the most potent marine toxins known. Consumption of fish contaminated with sufficient quantities of CTXs causes Ciguatera Fish Poisoning (CFP), the largest cause of non-bacterial food poisoning worldwide. Maitotoxins, which can be found in the digestive system of fish, could also contribute to CFP if such tissues are consumed. Recently, an increasing number of Gambierdiscus species have been identified; yet, little is known about the variation in toxicity among Gambierdiscus strains or species...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28363127/tissue-uptake-distribution-and-excretion-of-brevetoxin-3-after-oral-and-intratracheal-exposure-in-the-freshwater-turtle-trachemys-scripta-and-the-diamondback-terrapin-malaclemys-terrapin
#11
Courtney C Cocilova, Leanne J Flewelling, Gregory D Bossart, April A Granholm, Sarah L Milton
Harmful algal blooms (HABs) occur nearly annually off the west coast of Florida and can impact both humans and wildlife, resulting in morbidity and increased mortality of marine animals including sea turtles. The key organism in Florida red tides is the dinoflagellate Karenia brevis that produces a suite of potent neurotoxins referred to as the brevetoxins (PbTx). Despite recent mortality events and rehabilitation efforts, still little is known about how the toxin directly impacts sea turtles, as they are not amenable to experimentation and what is known about toxin levels and distribution comes primarily from post-mortem data...
March 7, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28358320/from-marine-venoms-to-drugs-efficiently-supported-by-a-combination-of-transcriptomics-and-proteomics
#12
REVIEW
Bing Xie, Yu Huang, Kate Baumann, Bryan Grieg Fry, Qiong Shi
The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), it has been much easier and faster to identify more toxins and predict their functions with bioinformatics pipelines, which pave the way for novel drug developments...
March 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28342004/modulatory-effects-of-terminalia-arjuna-against-domoic-acid-induced-toxicity-in-caco-2-cell-line
#13
E M Ramya, G Phani Kumar, T Anand, K R Anilakumar
Domoic acid is a potent marine algal toxin produced by diatomic genus of Pseudo-nitzschia causing amnesic shell fish poisoning. Domoic acid toxicosis mainly involves excitotoxic effects coupled with oxidative stress. The present study was aimed to evaluate the protective effects of hydro-alcoholic extract of Terminalia arjuna (TA) against domoic acid induced toxic effects in Caco-2 cell line. It was observed that the toxicity induced by domoic acid in Caco-2 cells was mediated by oxidative insult leading to morphological changes, DNA damage and apoptosis...
March 24, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28341681/chromosome-encoded-hemolysin-phospholipase-and-collagenase-contribute-to-virulence-for-fish-in-plasmidless-isolates-of-photobacterium-damselae-subsp-damselae
#14
Ana Vences, Amable J Rivas, Manuel L Lemos, Matthias Husmann, Carlos R Osorio
Photobacterium damselae subsp. damselae is a pathogen of marine animals including fish of importance in aquaculture. The virulence plasmid pPHDD1, characteristic of highly hemolytic isolates, encodes the hemolysins damselysin (Dly) and phobalysin (PhlyP). Strains lacking pPHDD1 constitute the vast majority of the isolates from fish outbreaks, but genetic studies to identify virulence factors in plasmidless strains are scarce. Here we show that the chromosome-I encoded hemolysin PhlyC plays a role in virulence and cell toxicity in pPHDD1-negative isolates of this pathogen...
March 24, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28324231/occurrence-and-virulence-properties-of-vibrio-and-salinivibrio-isolates-from-tropical-lagoons-of-the-southern-caribbean-sea
#15
Milagro Fernández-Delgado, Paula Suárez, Sandra Giner, Virginia Sanz, Jessy Peña, Damarys Sánchez, M Alexandra García-Amado
The Vibrionaceae are Gram-negative bacteria present in marine and estuarine environments worldwide, including several species known as important pathogens to humans and aquatic organisms. The aim of this research was to investigate the occurrence and virulence properties of Vibrio and Salinivibrio isolated from lagoons at Cuare Wildlife Refuge and Margarita Island in the southern Caribbean Sea. Water, plankton and oyster samples were collected during October 2011 and March 2012 and examined by specific PCR and culture methods...
March 21, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28277184/quercetin-attenuates-domoic-acid-induced-cognitive-deficits-in-mice
#16
Dongmei Wang, Jianlong Zhao, Sanqiang Li, Guomin Shen, Shu Hu
Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries principally in the hippocampal area. Accumulating evidence indicates that mitochondrial dysfunction and oxidative stress are involved in DA-induced cognitive functional impairment. Therefore, therapeutics targeted to improve mitochondrial function and increase oxidative stress defence could be beneficial...
September 26, 2016: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28262632/pufferfish-mortality-associated-with-novel-polar-marine-toxins-in-hawaii
#17
Thierry M Work, Peter D R Moeller, Kevin R Beauchesne, Julie Dagenais, Renee Breeden, Robert Rameyer, William J Walsh, Melanie Abecassis, Donald R Kobayashi, Carla Conway, James Winton
Fish die-offs are important signals in tropical marine ecosystems. In 2010, a mass mortality of pufferfish in Hawaii (USA) was dominated by Arothron hispidus showing aberrant neurological behaviors. Using pathology, toxinology, and field surveys, we implicated a series of novel, polar, marine toxins as a likely cause of this mass mortality. Our findings are striking in that (1) a marine toxin was associated with a kill of a fish species that is itself toxic; (2) we provide a plausible mechanism to explain clinical signs of affected fish; and (3) this epizootic likely depleted puffer populations...
March 6, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28256705/the-centrifugal-visual-system-of-a-palaeognathous-bird-the-chilean-tinamou-nothoprocta-perdicaria
#18
Quirin Krabichler, Tomas Vega-Zuniga, Denisse Carrasco, Maximo Fernandez, Cristián Gutiérrez-Ibáñez, Gonzalo Marín, Harald Luksch
The avian centrifugal visual system, which projects from the brain to the retina, has been intensively studied in several Neognathous birds that have a distinct isthmo-optic nucleus (ION). However, birds of the order Palaeognathae seem to lack a proper ION in histologically stained brain sections. We had previously reported in the palaeognathous Chilean Tinamou (Nothoprocta perdicaria) that intraocular injections of Cholera Toxin B subunit retrogradely label a considerable number of neurons, which form a diffuse isthmo-optic complex (IOC)...
March 3, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28241803/predator-cues-reduce-intraspecific-trait-variability-in-a-marine-dinoflagellate
#19
Sylke Wohlrab, Erik Selander, U John
BACKGROUND: Phenotypic plasticity is commonplace and enables an organism to respond to variations in the environment. Plastic responses often modify a suite of traits and can be triggered by both abiotic and biotic changes. Here we analysed the plastic response towards a grazer of two genotypes of the marine dinoflagellate Alexandrium fundyense, evaluated the similarity of this response and discuss potential strain-specific trade-offs. We compared the expression of the known inducible defensive traits paralytic shellfish toxin content, and chain length...
February 27, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28224710/extended-low-dose-exposure-to-saxitoxin-inhibits-neurite-outgrowth-in-model-neuronal-cells
#20
Katie O'Neill, Ian F Musgrave, Andrew Humpage
The potent neurotoxin saxitoxin (STX) belongs to a group of structurally related analogues produced by both marine and freshwater phytoplankton. The toxins act by blocking voltage-gated sodium channels stopping the inflow of sodium ions and the generation of action potentials. Exposure from marine sources occurs as a result of consuming shellfish which have concentrated the toxins, and freshwater exposure can occur from drinking water although there have been no acute poisonings from the latter source to date...
April 2017: Basic & Clinical Pharmacology & Toxicology
keyword
keyword
18588
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"