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https://www.readbyqxmd.com/read/29770692/highly-sensitive-and-practical-fluorescent-sandwich-elisa-for-ciguatoxins
#1
Takeshi Tsumuraya, Takeshi Sato, Masahiro Hirama, Ikuo Fujii
Ciguatera fish poisoning (CFP) caused by the consumption of fish that have accumulated ciguatoxins (CTXs) affects more than 50,000 people annually. The spread of CFP causes enormous damage to public health, fishery resources, and the economies of tropical and subtropical endemic regions. The difficulty in avoiding CFP arises from the lack of sensitive and reliable analytical methods for the detection and quantification of CTXs in contaminated fish, along with the normal appearance, smell, and taste of fish contaminated with the causative toxins...
May 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29748486/transcriptomic-analysis-of-ciguatoxin-induced-changes-in-gene-expression-in-primary-cultures-of-mice-cortical-neurons
#2
Juan Andrés Rubiolo, Carmen Vale, Andrea Boente-Juncal, Masahiro Hirama, Shuji Yamashita, Mercedes Camiña, Mercedes R Vieytes, Luis M Botana
Ciguatoxins are polyether marine toxins that act as sodium channel activators. These toxins cause ciguatera, one of the most widespread nonbacterial forms of food poisoning, which presents several symptoms in humans including long-term neurological alterations. Earlier work has shown that both acute and chronic exposure of primary cortical neurons to synthetic ciguatoxin CTX3C have profound impacts on neuronal function. Thus, the present work aimed to identify relevant neuronal genes and metabolic pathways that could be altered by ciguatoxin exposure...
May 10, 2018: Toxins
https://www.readbyqxmd.com/read/29747460/tissue-distribution-and-elimination-of-ciguatoxins-in-tridacna-maxima-tridacnidae-bivalvia-fed-gambierdiscus-polynesiensis
#3
Mélanie Roué, Hélène Taiana Darius, André Ung, Jérôme Viallon, Manoella Sibat, Philipp Hess, Zouher Amzil, Mireille Chinain
Ciguatera is a foodborne disease caused by the consumption of seafood contaminated with ciguatoxins (CTXs). Ciguatera-like poisoning events involving giant clams ( Tridacna maxima ) are reported occasionally from Pacific islands communities. The present study aimed at providing insights into CTXs tissue distribution and detoxification rate in giant clams exposed to toxic cells of Gambierdiscus polynesiensis , in the framework of seafood safety assessment. In a first experiment, three groups of tissue (viscera, flesh and mantle) were dissected from exposed individuals, and analyzed for their toxicity using the neuroblastoma cell-based assay (CBA-N2a) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses...
May 10, 2018: Toxins
https://www.readbyqxmd.com/read/29724345/phylogeny-morphology-and-toxicity-of-benthic-dinoflagellates-of-the-genus-fukuyoa-goniodomataceae-dinophyceae-from-a-subtropical-reef-ecosystem-in-the-south-china-sea
#4
Priscilla T Y Leung, Meng Yan, Veronica T T Lam, Sam K F Yiu, Chia-Yun Chen, J Sam Murray, D Tim Harwood, Lesley L Rhodes, Paul K S Lam, Tak-Cheung Wai
Species of Fukuyoa, recently revised from the globular Gambierdiscus, are toxic benthic dinoflagellates associated with ciguatera. In this study, a total of ten strains of Fukuyoa collected from Hong Kong waters were characterized using morphological and phylogenetic analyses. Results from both analyses showed that one of the strains is a putative new species, namely Fukuyoa sp. HK Type 1 (plate formula Po, 3', 7″, 6c, 7s, 5‴, 1p and 2'‴ with a distinctive small and narrow cell shape, narrow Po plate, high Po pore density, large and broad Plate 1' but small and round Po pore size, small and narrow Plate 2', long and narrow Plates 2'‴ and 1p), and the others were F...
April 2018: Harmful Algae
https://www.readbyqxmd.com/read/29710376/ciguatoxin-prevalence-in-4-commercial-fish-species-along-an-oceanic-exposure-gradient-in-the-us-virgin-islands
#5
Christopher R Loeffler, Alison Robertson, Harold A Flores Quintana, Miguel C Silander, Tyler B Smith, David Olsen
Ciguatera fish poisoning is a seafood-toxin illness resulting from consumption of fish contaminated with ciguatoxins. Managing ciguatera fish poisoning is complex. It is made easier, however, by local fishers from endemic areas reporting regional predictability for local fish species' ciguatera fish poisoning risk, which the present study then tested. We investigated the prevalence of ciguatoxins in 4 commonly marketed and consumed species (Balistes vetula, Haemulon plumierii, Ocyurus chrysurus, and Epinephelus guttatus) across an oceanic gradient (north, south, east, and west) from the US Virgin Islands...
April 30, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29642418/toxicological-investigations-on-the-sea-urchin-tripneustes-gratilla-toxopneustidae-echinoid-from-anaho-bay-nuku-hiva-french-polynesia-evidence-for-the-presence-of-pacific-ciguatoxins
#6
Hélène Taiana Darius, Mélanie Roué, Manoella Sibat, Jérôme Viallon, Clémence Mahana Iti Iti Gatti, Mark W Vandersea, Patricia A Tester, R Wayne Litaker, Zouher Amzil, Philipp Hess, Mireille Chinain
The sea urchin Tripneustes gratilla ( Toxopneustidae , Echinoids) is a source of protein for many islanders in the Indo-West Pacific. It was previously reported to occasionally cause ciguatera-like poisoning; however, the exact nature of the causative agent was not confirmed. In April and July 2015, ciguatera poisonings were reported following the consumption of T. gratilla in Anaho Bay (Nuku Hiva Island, Marquesas archipelago, French Polynesia). Patient symptomatology was recorded and sea urchin samples were collected from Anaho Bay in July 2015 and November 2016...
April 6, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29495579/tectus-niloticus-tegulidae-gastropod-as-a-novel-vector-of-ciguatera-poisoning-clinical-characterization-and-follow-up-of-a-mass-poisoning-event-in-nuku-hiva-island-french-polynesia
#7
Clémence Mahana Iti Gatti, Davide Lonati, Hélène Taiana Darius, Arturo Zancan, Mélanie Roué, Azzurra Schicchi, Carlo Alessandro Locatelli, Mireille Chinain
Ciguatera fish poisoning (CFP) is the most prevalent non-bacterial food-borne form of poisoning in French Polynesia, which results from the consumption of coral reef fish naturally contaminated with ciguatoxins produced by dinoflagellates in the genus Gambierdiscus . Since the early 2000s, this French territory has also witnessed the emergence of atypical forms of ciguatera, known as ciguatera shellfish poisoning (CSP), associated with the consumption of marine invertebrates. In June 2014, nine tourists simultaneously developed a major and persistent poisoning syndrome following the consumption of the gastropod Tectus niloticus collected in Anaho, a secluded bay of Nuku Hiva Island (Marquesas Archipelago, French Polynesia)...
February 28, 2018: Toxins
https://www.readbyqxmd.com/read/29449664/incidence-and-clinical-characteristics-of-ciguatera-fish-poisoning-in-guadeloupe-french-west-indies-between-2013-and-2016-a-retrospective-cases-series
#8
Denis Boucaud-Maitre, Jean-Paul Vernoux, Stéphane Pelczar, Elise Daudens-Vaysse, Lyderic Aubert, Sylvie Boa, Serge Ferracci, Robert Garnier
This retrospective case study analysed the incidence and symptoms of ciguatera fish poisoning (ciguatera) in Guadeloupe (French West Indies) between 2013 and 2016. Cases attending the emergency departments of the two public hospitals and the reports received by the regional health authority in charge of monitoring (ARS) were compiled. Two hundred and thirty-four cases of poisoning were observed, with a mean annual incidence of 1.47/10,000 (95% CI): 1.29-1.66), i.e 5 times higher than the previously reported incidence (1996-2006)...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29360534/immune-effects-of-the-neurotoxins-ciguatoxins-and-brevetoxins
#9
Ophelie Pierre, Laurent Misery, Matthieu Talagas, Raphaele Le Garrec
Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain, pruritus and cold dysaesthesia), which can persist several weeks and, in some cases, several months or years. NSP is considered a mild form of CFP with similar but less severe symptoms...
January 25, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29349574/pacific-ciguatoxin-induces-excitotoxicity-and-neurodegeneration-in-the-motor-cortex-via-caspase-3-activation-implication-for-irreversible-motor-deficit
#10
Pallavi Asthana, Ni Zhang, Gajendra Kumar, Virendra Bhagawan Chine, Kunal Kumar Singh, Yim Ling Mak, Leo Lai Chan, Paul Kwan Sing Lam, Chi Him Eddie Ma
Consumption of fish containing ciguatera toxins or ciguatoxins (CTXs) causes ciguatera fish poisoning (CFP). In some patients, CFP recurrence occurs even years after exposure related to CTXs accumulation. Pacific CTX-1 (P-CTX-1) is one of the most potent natural substances known that causes predominantly neurological symptoms in patients; however, the underlying pathogenies of CFP remain unknown. Using clinically relevant neurobehavioral tests and electromyography (EMG) to assess effects of P-CTX-1 during the 4 months after exposure, recurrent motor strength deficit occurred in mice exposed to P-CTX-1...
January 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29306662/ciguatoxins-activate-the-calcineurin-signalling-pathway-in-yeasts-potential-for-development-of-an-alternative-detection-tool
#11
Hélène Martin-Yken, Camille Gironde, Sylvain Derick, Hélène Taiana Darius, Christophe Furger, Dominique Laurent, Mireille Chinain
Ciguatoxins (CTXs) are lipid-soluble polyether compounds produced by dinoflagellates from the genus Gambierdiscus spp. typically found in tropical and subtropical zones. This endemic area is however rapidly expanding due to environmental perturbations, and both toxic Gambierdiscus spp. and ciguatoxic fishes have been recently identified in the North Atlantic Ocean (Madeira and Canary islands) and Mediterranean Sea. Ciguatoxins bind to Voltage Gated Sodium Channels on the membranes of sensory neurons, causing Ciguatera Fish Poisoning (CFP) in humans, a disease characterized by a complex array of gastrointestinal, neurological, neuropsychological, and cardiovascular symptoms...
April 2018: Environmental Research
https://www.readbyqxmd.com/read/29306395/application-of-solid-phase-adsorption-toxin-tracking-spatt-devices-for-the-field-detection-of-gambierdiscus-toxins
#12
Mélanie Roué, Hélène Taiana Darius, Jérôme Viallon, André Ung, Clémence Gatti, D Tim Harwood, Mireille Chinain
Ciguatera fish poisoning is a food-borne illness caused by the consumption of seafood contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the Gambierdiscus genus. Since most surveillance programs currently rely on the survey of Gambierdiscus cell densities and species composition, supplementary toxin-based methods allowing the time- and spatially integrated sampling of toxins in ciguateric environments are needed for a more reliable assessment and management of the risks associated with Gambierdiscus proliferation...
January 2018: Harmful Algae
https://www.readbyqxmd.com/read/29301247/toxicology-of-gambierdiscus-spp-dinophyceae-from-tropical-and-temperate-australian-waters
#13
Michaela E Larsson, Olivier F Laczka, D Tim Harwood, Richard J Lewis, S W A Himaya, Shauna A Murray, Martina A Doblin
Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced by species from the benthic dinoflagellate genus Gambierdiscus . Here, we describe the identity and toxicology of Gambierdiscus spp. isolated from the tropical and temperate waters of eastern Australia. Based on newly cultured strains, we found that four Gambierdiscus species were present at the tropical location, including G. carpenteri , G...
January 1, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29169571/differences-in-the-photoacclimation-and-photoprotection-exhibited-by-two-species-of-the-ciguatera-causing-dinoflagellate-genus-gambierdiscus
#14
Alexander K Leynse, Michael L Parsons, Serge E Thomas
In culture, Gambierdiscus spp. have been shown to prefer irradiances that are relatively low (≤250μmol photonsm-2 s-1 ) versus those to which they are frequently exposed to in their natural environment (>500μmol photonsm-2 s-1 ). Although several behavioral strategies for coping with such irradiances have been suggested, it is unclear as to how these dinoflagellates do so on a physiological level. More specifically, how do long term exposures (30days) affect cell size and cellular chlorophyll content, and what is the photosynthetic response to short term, high irradiance exposures (up to 1464μmol photonsm-2 s-1 )? The results of this study reveal that cell size and chlorophyll content exhibited by G...
December 2017: Harmful Algae
https://www.readbyqxmd.com/read/29135913/management-of-ciguatoxin-risk-in-eastern-australia
#15
Hazel Farrell, Shauna A Murray, Anthony Zammit, Alan W Edwards
Between 2014 and 2016, five cases of ciguatera fish poisoning (CFP), involving twenty four individuals, were linked to Spanish Mackerel ( Scomberomorus commerson ) caught in the coastal waters of the state of New South Wales (NSW) on the east coast of Australia. Previously, documented cases of CFP in NSW were few, and primarily linked to fish imported from other regions. Since 2015, thirteen individuals were affected across four additional CFP cases in NSW, linked to fish imported from tropical locations. The apparent increase in CFP in NSW from locally sourced catch, combined with the risk of CFP from imported fish, has highlighted several considerations that should be incorporated into risk management strategies to minimize CFP exposure for seafood consumers...
November 14, 2017: Toxins
https://www.readbyqxmd.com/read/29045489/ciguatoxicity-of-gambierdiscus-and-fukuyoa-species-from-the-caribbean-and-gulf-of-mexico
#16
R Wayne Litaker, William C Holland, D Ransom Hardison, Francesco Pisapia, Philipp Hess, Steven R Kibler, Patricia A Tester
Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP...
2017: PloS One
https://www.readbyqxmd.com/read/29023382/quantification-of-representative-ciguatoxins-in-the-pacific-using-quantitative-nuclear-magnetic-resonance-spectroscopy
#17
Tsuyoshi Kato, Takeshi Yasumoto
The absolute quantification of five toxins involved in ciguatera fish poisoning (CFP) in the Pacific was carried out by quantitative ¹H-NMR. The targeted toxins were ciguatoxin-1B (CTX1B), 52-epi-54-deoxyciguatoxin-1B (epideoxyCTX1B), ciguatoxin-3C (CTX3C), 51-hydroxyciguatoxin-3C (51OHCTX3C), and ciguatoxin-4A (CTX4A). We first calibrated the residual protons of pyridine- d ₅ using certified reference material, 1,4-BTMSB- d ₄, prepared the toxin solutions with the calibrated pyridin- d ₅, measured the ¹H-NMR spectra, and quantified the toxin using the calibrated residual protons as the internal standard...
October 12, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29017199/-ciguatera-or-why-you-should-enquire-about-fish-consumption-in-cases-of-cold-allodynia
#18
Miriam Friedemann, Claus Doberauer, Gereon R Fink, Lothar Burghaus
Ciguatoxine sind potente, von Mikroalgen produzierte, marine Biotoxine, die sich in tropischen Raubfischen, lokal und saisonal unterschiedlich stark, anreichern können. Kurze Zeit nach dem Fischverzehr treten gastrointestinale, neurologische und/oder kardiovaskuläre Vergiftungssymptome auf. Durch die hohe Affinität der Toxine zu neuronalen Natriumkanälen sind neurologische Symptome für Ciguatera-Vergiftungen charakteristisch. Nahezu pathognomonisch ist dabei die Kälteallodynie, bei der kalte Oberflächen als heiß, schmerzhaft oder extrem unangenehm empfunden werden...
October 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28962987/corrigendum-to-canary-islands-ne-atlantic-as-a-biodiversity-hotspot-of-gambierdiscus-implications-for-future-trends-of-ciguatera-in-the-area
#19
Francisco Rodríguez, Santiago Fraga, Isabel Ramilo, Pilar Rial, Rosa Isabel Figueroa, Pilar Riobó, Isabel Bravo
No abstract text is available yet for this article.
September 2017: Harmful Algae
https://www.readbyqxmd.com/read/28962981/the-prevalence-of-benthic-dinoflagellates-associated-with-ciguatera-fish-poisoning-in-the-central-red-sea
#20
Daniela Catania, Mindy L Richlen, Yim Ling Mak, Steve L Morton, Elizabeth H Laban, Yixiao Xu, Donald M Anderson, Leo Lai Chan, Michael L Berumen
This study confirms the presence of the toxigenic benthic dinoflagellates Gambierdiscus belizeanus and Ostreopsis spp. in the central Red Sea. To our knowledge, this is also the first report of these taxa in coastal waters of Saudi Arabia, indicating the potential occurrence of ciguatera fish poisoning (CFP) in that region. During field investigations carried out in 2012 and 2013, a total of 100 Turbinaria and Halimeda macroalgae samples were collected from coral reefs off the Saudi Arabian coast and examined for the presence of Gambierdiscus and Ostreopsis, two toxigenic dinoflagellate genera commonly observed in coral reef communities around the world...
September 2017: Harmful Algae
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