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https://www.readbyqxmd.com/read/29642418/toxicological-investigations-on-the-sea-urchin-tripneustes-gratilla-toxopneustidae-echinoid-from-anaho-bay-nuku-hiva-french-polynesia-evidence-for-the-presence-of-pacific-ciguatoxins
#1
Hélène Taiana Darius, Mélanie Roué, Manoella Sibat, Jérôme Viallon, Clémence Mahana Iti Iti Gatti, Mark W Vandersea, Patricia A Tester, R Wayne Litaker, Zouher Amzil, Philipp Hess, Mireille Chinain
The sea urchin Tripneustes gratilla ( Toxopneustidae , Echinoids) is a source of protein for many islanders in the Indo-West Pacific. It was previously reported to occasionally cause ciguatera-like poisoning; however, the exact nature of the causative agent was not confirmed. In April and July 2015, ciguatera poisonings were reported following the consumption of T. gratilla in Anaho Bay (Nuku Hiva Island, Marquesas archipelago, French Polynesia). Patient symptomatology was recorded and sea urchin samples were collected from Anaho Bay in July 2015 and November 2016...
April 6, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29502403/selective-extraction-and-purification-of-azaspiracids-from-blue-mussels-mytilus-edulis-using-boric-acid-gel
#2
Christopher O Miles, Jane Kilcoyne, Pearse McCarron, Sabrina D Giddings, Thor Waaler, Thomas Rundberget, Ingunn A Samdal, Kjersti E Løvberg
Azaspiracids (AZAs) belong to a family of more than 50 polyether toxins originating from marine dinoflagellates such as Azadinium spinosum. All of the AZAs reported thus far contain a 21,22-dihydroxy group. Boric acid gel (BAG) can bind selectively to compounds containing vic-diols or α-hydroxycarboxylic acids via formation of reversible boronate complexes. Here we report use of BAG to selectively capture and release AZAs from extracts of blue mussels. Analysis of the extracts and BAG fractions by LC-MS showed that this procedure resulted in an excellent clean-up of the AZAs in the extract...
March 4, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29495579/tectus-niloticus-tegulidae-gastropod-as-a-novel-vector-of-ciguatera-poisoning-clinical-characterization-and-follow-up-of-a-mass-poisoning-event-in-nuku-hiva-island-french-polynesia
#3
Clémence Mahana Iti Gatti, Davide Lonati, Hélène Taiana Darius, Arturo Zancan, Mélanie Roué, Azzurra Schicchi, Carlo Alessandro Locatelli, Mireille Chinain
Ciguatera fish poisoning (CFP) is the most prevalent non-bacterial food-borne form of poisoning in French Polynesia, which results from the consumption of coral reef fish naturally contaminated with ciguatoxins produced by dinoflagellates in the genus Gambierdiscus . Since the early 2000s, this French territory has also witnessed the emergence of atypical forms of ciguatera, known as ciguatera shellfish poisoning (CSP), associated with the consumption of marine invertebrates. In June 2014, nine tourists simultaneously developed a major and persistent poisoning syndrome following the consumption of the gastropod Tectus niloticus collected in Anaho, a secluded bay of Nuku Hiva Island (Marquesas Archipelago, French Polynesia)...
February 28, 2018: Toxins
https://www.readbyqxmd.com/read/29360534/immune-effects-of-the-neurotoxins-ciguatoxins-and-brevetoxins
#4
Ophelie Pierre, Laurent Misery, Matthieu Talagas, Raphaele Le Garrec
Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain, pruritus and cold dysaesthesia), which can persist several weeks and, in some cases, several months or years. NSP is considered a mild form of CFP with similar but less severe symptoms...
January 25, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29349574/pacific-ciguatoxin-induces-excitotoxicity-and-neurodegeneration-in-the-motor-cortex-via-caspase-3-activation-implication-for-irreversible-motor-deficit
#5
Pallavi Asthana, Ni Zhang, Gajendra Kumar, Virendra Bhagawan Chine, Kunal Kumar Singh, Yim Ling Mak, Leo Lai Chan, Paul Kwan Sing Lam, Chi Him Eddie Ma
Consumption of fish containing ciguatera toxins or ciguatoxins (CTXs) causes ciguatera fish poisoning (CFP). In some patients, CFP recurrence occurs even years after exposure related to CTXs accumulation. Pacific CTX-1 (P-CTX-1) is one of the most potent natural substances known that causes predominantly neurological symptoms in patients; however, the underlying pathogenies of CFP remain unknown. Using clinically relevant neurobehavioral tests and electromyography (EMG) to assess effects of P-CTX-1 during the 4 months after exposure, recurrent motor strength deficit occurred in mice exposed to P-CTX-1...
January 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29306662/ciguatoxins-activate-the-calcineurin-signalling-pathway-in-yeasts-potential-for-development-of-an-alternative-detection-tool
#6
Hélène Martin-Yken, Camille Gironde, Sylvain Derick, Hélène Taiana Darius, Christophe Furger, Dominique Laurent, Mireille Chinain
Ciguatoxins (CTXs) are lipid-soluble polyether compounds produced by dinoflagellates from the genus Gambierdiscus spp. typically found in tropical and subtropical zones. This endemic area is however rapidly expanding due to environmental perturbations, and both toxic Gambierdiscus spp. and ciguatoxic fishes have been recently identified in the North Atlantic Ocean (Madeira and Canary islands) and Mediterranean Sea. Ciguatoxins bind to Voltage Gated Sodium Channels on the membranes of sensory neurons, causing Ciguatera Fish Poisoning (CFP) in humans, a disease characterized by a complex array of gastrointestinal, neurological, neuropsychological, and cardiovascular symptoms...
April 2018: Environmental Research
https://www.readbyqxmd.com/read/29306395/application-of-solid-phase-adsorption-toxin-tracking-spatt-devices-for-the-field-detection-of-gambierdiscus-toxins
#7
Mélanie Roué, Hélène Taiana Darius, Jérôme Viallon, André Ung, Clémence Gatti, D Tim Harwood, Mireille Chinain
Ciguatera fish poisoning is a food-borne illness caused by the consumption of seafood contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the Gambierdiscus genus. Since most surveillance programs currently rely on the survey of Gambierdiscus cell densities and species composition, supplementary toxin-based methods allowing the time- and spatially integrated sampling of toxins in ciguateric environments are needed for a more reliable assessment and management of the risks associated with Gambierdiscus proliferation...
January 2018: Harmful Algae
https://www.readbyqxmd.com/read/29301247/toxicology-of-gambierdiscus-spp-dinophyceae-from-tropical-and-temperate-australian-waters
#8
Michaela E Larsson, Olivier F Laczka, D Tim Harwood, Richard J Lewis, S W A Himaya, Shauna A Murray, Martina A Doblin
Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced by species from the benthic dinoflagellate genus Gambierdiscus . Here, we describe the identity and toxicology of Gambierdiscus spp. isolated from the tropical and temperate waters of eastern Australia. Based on newly cultured strains, we found that four Gambierdiscus species were present at the tropical location, including G. carpenteri , G...
January 1, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29135913/management-of-ciguatoxin-risk-in-eastern-australia
#9
Hazel Farrell, Shauna A Murray, Anthony Zammit, Alan W Edwards
Between 2014 and 2016, five cases of ciguatera fish poisoning (CFP), involving twenty four individuals, were linked to Spanish Mackerel ( Scomberomorus commerson ) caught in the coastal waters of the state of New South Wales (NSW) on the east coast of Australia. Previously, documented cases of CFP in NSW were few, and primarily linked to fish imported from other regions. Since 2015, thirteen individuals were affected across four additional CFP cases in NSW, linked to fish imported from tropical locations. The apparent increase in CFP in NSW from locally sourced catch, combined with the risk of CFP from imported fish, has highlighted several considerations that should be incorporated into risk management strategies to minimize CFP exposure for seafood consumers...
November 14, 2017: Toxins
https://www.readbyqxmd.com/read/29045489/ciguatoxicity-of-gambierdiscus-and-fukuyoa-species-from-the-caribbean-and-gulf-of-mexico
#10
R Wayne Litaker, William C Holland, D Ransom Hardison, Francesco Pisapia, Philipp Hess, Steven R Kibler, Patricia A Tester
Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP...
2017: PloS One
https://www.readbyqxmd.com/read/29023382/quantification-of-representative-ciguatoxins-in-the-pacific-using-quantitative-nuclear-magnetic-resonance-spectroscopy
#11
Tsuyoshi Kato, Takeshi Yasumoto
The absolute quantification of five toxins involved in ciguatera fish poisoning (CFP) in the Pacific was carried out by quantitative ¹H-NMR. The targeted toxins were ciguatoxin-1B (CTX1B), 52-epi-54-deoxyciguatoxin-1B (epideoxyCTX1B), ciguatoxin-3C (CTX3C), 51-hydroxyciguatoxin-3C (51OHCTX3C), and ciguatoxin-4A (CTX4A). We first calibrated the residual protons of pyridine- d ₅ using certified reference material, 1,4-BTMSB- d ₄, prepared the toxin solutions with the calibrated pyridin- d ₅, measured the ¹H-NMR spectra, and quantified the toxin using the calibrated residual protons as the internal standard...
October 12, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29017199/-ciguatera-or-why-you-should-enquire-about-fish-consumption-in-cases-of-cold-allodynia
#12
Miriam Friedemann, Claus Doberauer, Gereon R Fink, Lothar Burghaus
Ciguatoxine sind potente, von Mikroalgen produzierte, marine Biotoxine, die sich in tropischen Raubfischen, lokal und saisonal unterschiedlich stark, anreichern können. Kurze Zeit nach dem Fischverzehr treten gastrointestinale, neurologische und/oder kardiovaskuläre Vergiftungssymptome auf. Durch die hohe Affinität der Toxine zu neuronalen Natriumkanälen sind neurologische Symptome für Ciguatera-Vergiftungen charakteristisch. Nahezu pathognomonisch ist dabei die Kälteallodynie, bei der kalte Oberflächen als heiß, schmerzhaft oder extrem unangenehm empfunden werden...
October 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28962981/the-prevalence-of-benthic-dinoflagellates-associated-with-ciguatera-fish-poisoning-in-the-central-red-sea
#13
Daniela Catania, Mindy L Richlen, Yim Ling Mak, Steve L Morton, Elizabeth H Laban, Yixiao Xu, Donald M Anderson, Leo Lai Chan, Michael L Berumen
This study confirms the presence of the toxigenic benthic dinoflagellates Gambierdiscus belizeanus and Ostreopsis spp. in the central Red Sea. To our knowledge, this is also the first report of these taxa in coastal waters of Saudi Arabia, indicating the potential occurrence of ciguatera fish poisoning (CFP) in that region. During field investigations carried out in 2012 and 2013, a total of 100 Turbinaria and Halimeda macroalgae samples were collected from coral reefs off the Saudi Arabian coast and examined for the presence of Gambierdiscus and Ostreopsis, two toxigenic dinoflagellate genera commonly observed in coral reef communities around the world...
September 2017: Harmful Algae
https://www.readbyqxmd.com/read/28959656/qualitative-and-quantitative-assessment-of-the-presence-of-ciguatoxin-p-ctx-1b-in-spanish-mackerel-scomberomorus-commerson-from-waters-in-new-south-wales-australia
#14
Gurjeet S Kohli, Kristina Haslauer, Chowdhury Sarowar, Anna Liza Kretzschmar, Mark Boulter, D Tim Harwood, Olivier Laczka, Shauna A Murray
Ciguatera Fish Poisoning (CFP) is a tropical disease caused by the consumption of fish contaminated with ciguatoxins (CTXs). Currently, the only feasible prevention methods for CFP are to avoid the consumption of fish of certain species from some regions, avoid larger fish of certain species, or avoid all fish caught from specific regions. Here, we quantified levels of P-CTX-1B in Spanish Mackerel (Scomberomorus commerson), which is the main fish species that causes CFP in New South Wales and Queensland, Australia, using LC-MS detection against a toxin standard...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28884655/screening-for-the-presence-of-lipophilic-marine-biotoxins-in-shellfish-samples-using-the-neuro-2a-bioassay
#15
Marcia Bodero, Toine F H Bovee, Si Wang, Ron L A P Hoogenboom, Mirjam D Klijnstra, Liza Portier, Peter J M Hendriksen, Arjen Gerssen
The neuro-2a bioassay is considered as one of the most promising cell-based in vitro bioassays for the broad screening of seafood products for the presence of marine biotoxins. The neuro-2a assay has been shown to detect a wide array of toxins like paralytic shellfish poisons (PSPs), ciguatoxins, and also lipophilic marine biotoxins (LMBs). However, the neuro-2a assay is rarely used for routine testing of samples due to matrix effects that, for example, lead to false positives when testing for LMBs. As a result there are only limited data on validation and evaluation of its performance on real samples...
September 8, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28867800/ciguatoxins-evoke-potent-cgrp-release-by-activation-of-voltage-gated-sodium-channel-subtypes-nav1-9-nav1-7-and-nav1-1
#16
Filip Touska, Simon Sattler, Philipp Malsch, Richard J Lewis, Peter W Reeh, Katharina Zimmermann
Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium channel activator toxins, the etiology of many of its neurosensory symptoms remains unresolved. We recently described that local application of 1 nM Pacific Ciguatoxin-1 (P-CTX-1) into the skin of human subjects induces a long-lasting, painful axon reflex flare and that CTXs are particularly effective in releasing calcitonin-gene related peptide (CGRP) from nerve terminals...
August 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28836116/mechanisms-and-effects-posed-by-neurotoxic-products-of-cyanobacteria-microbial-eukaryotes-dinoflagellates-in-algae-blooms-a-review
#17
Fiona D Mello, Nady Braidy, Helder Marçal, Gilles Guillemin, Seyed Mohammad Nabavi, Brett A Neilan
Environmental toxins produced by cyanobacteria and dinoflagellates have increasingly become a public health concern due to their ability to damage several tissues in humans. In particular, emerging evidence has called attention to the neurodegenerative effects of the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA). Furthermore, other toxins such as anatoxin, saxitoxin, microcystin, nodularin and ciguatoxin also have a different range of effects on human tissues, including hepatotoxicity, neurotoxicity and gastrointestinal irritation...
January 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/28811602/identification-of-ciguatoxins-in-a-shark-involved-in-a-fatal-food-poisoning-in-the-indian-ocean
#18
Jorge Diogène, Laia Reverté, Maria Rambla-Alegre, Vanessa Del Río, Pablo de la Iglesia, Mònica Campàs, Oscar Palacios, Cintia Flores, Josep Caixach, Christian Ralijaona, Iony Razanajatovo, Agathe Pirog, Hélène Magalon, Nathalie Arnich, Jean Turquet
Severe food poisoning events after the consumption of sharks have been reported since the 1940s; however, there has been no clear understanding of their cause. Herein, we report for the first time the presence of ciguatoxins (CTXs) in sharks. The identification by mass spectrometry of CTXs, including two new analogues, in a bull shark (Carcharhinus leucas) that was consumed by humans, causing the poisoning and death of 11 people in Madagascar in 2013 is described. Typical neurotoxic ciguatera symptoms were recorded in patients, and toxicological assays on extracts of the shark demonstrated CTX-like activity...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28767092/molecular-identification-of-gambierdiscus-and-fukuyoa-dinophyceae-from-environmental-samples
#19
Kirsty F Smith, Laura Biessy, Phoebe A Argyle, Tom Trnski, Tuikolongahau Halafihi, Lesley L Rhodes
Ciguatera Fish Poisoning (CFP) is increasing across the Pacific and the distribution of the causative dinoflagellates appears to be expanding. Subtle differences in thecal plate morphology are used to distinguish dinoflagellate species, which are difficult to determine using light microscopy. For these reasons we sought to develop a Quantitative PCR assay that would detect all species from both Gambierdiscus and Fukuyoa genera in order to rapidly screen environmental samples for potentially toxic species. Additionally, a specific assay for F...
August 2, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28755716/-canary-islands-ne-atlantic-as-a-biodiversity-hotspot-of-gambierdiscus-implications-for-future-trends-of-ciguatera-in-the-area
#20
Francisco Rodríguez, Santiago Fraga, Isabel Ramilo, Pilar Rial, Rosa Isabel Figueroa, Pilar Riobó, Isabel Bravo
In the present study the geographical distribution, abundance and composition of Gambierdiscus was described over a 600km longitudinal scale in the Canary Islands. Samples for cell counts, isolation and identification of Gambierdiscus were obtained from five islands (El Hierro, Tenerife, Gran Canaria, Fuerteventura and Lanzarote). Average densities of Gambierdiscus spp. between 0 and 2200cellsg(-1) blot dry weight of macrophyte were recorded. Morphological (light microscopy and SEM techniques) and molecular analyses (LSU and SSU rDNA sequencing of cultures and single cells from the field) of Gambierdiscus was performed...
July 2017: Harmful Algae
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