keyword
https://read.qxmd.com/read/38519777/development-of-a-simple-screening-method-for-analyzing-cereulide-toxin-in-fried-rice-using-liquid-chromatography-tandem-mass-spectrometry
#21
JOURNAL ARTICLE
Hiroshi Koike, Maki Kanda, Chie Monma, Souichi Yoshikawa, Hiroshi Hayashi, Yoko Matsushima, Yumi Ohba, Momoka Hayashi, Natsumi Furuta, Wakaba Okada, Chieko Nagano, Keiko Yokoyama, Tomoko Yokoyama, Takeo Sasamoto
PURPOSE: The presence of cereulide, an emetic toxin produced by Bacillus cereus, in fried rice samples is critical evidence of food poisoning even in situations where B. cereus could not be detected. This study aims to develop a screening method for analyzing cereulide in fried rice using the QuEChERS procedure and liquid chromatography-tandem mass spectrometry (LC-MS/MS). METHODS: Cereulide was identified and quantified in fried rice samples using the QuEChERS extraction method and LC-MS/MS...
March 22, 2024: Forensic Toxicology
https://read.qxmd.com/read/38519511/structure-of-the-human-bre1-complex-bound-to-the-nucleosome
#22
JOURNAL ARTICLE
Shuhei Onishi, Kotone Uchiyama, Ko Sato, Chikako Okada, Shunsuke Kobayashi, Keisuke Hamada, Tomohiro Nishizawa, Osamu Nureki, Kazuhiro Ogata, Toru Sengoku
Histone H2B monoubiquitination (at Lys120 in humans) regulates transcription elongation and DNA repair. In humans, H2B monoubiquitination is catalyzed by the heterodimeric Bre1 complex composed of Bre1A/RNF20 and Bre1B/RNF40. The Bre1 proteins generally function as tumor suppressors, while in certain cancers, they facilitate cancer cell proliferation. To obtain structural insights of H2BK120 ubiquitination and its regulation, we report the cryo-electron microscopy structure of the human Bre1 complex bound to the nucleosome...
March 22, 2024: Nature Communications
https://read.qxmd.com/read/38518393/combined-genetic-polymorphisms-of-the-gstt1-and-nrf2-genes-increase-susceptibility-to-cisplatin-induced-ototoxicity-a-preliminary-study
#23
JOURNAL ARTICLE
Taro Fujikawa, Taku Ito, Ryuhei Okada, Mitsutaka Sawada, Kaori Mohri, Yumiko Tateishi, Ryosuke Takahashi, Takahiro Asakage, Takeshi Tsutsumi
OBJECTIVE: The genotype-phenotype relationship in cisplatin-induced ototoxicity remains unclear. By assessing early shifts in distortion product otoacoustic emission (DPOAE) levels after initial cisplatin administration, we aimed to discriminate patients' susceptibility to cisplatin-induced ototoxicity and elucidate their genetic background. STUDY DESIGN: A prospective cross-sectional study. SETTING: Tertiary referral hospital in Japan. PATIENTS: Twenty-six patients with head and neck cancer were undergoing chemoradiotherapy with three cycles of 100 mg/m2 cisplatin...
March 20, 2024: Hearing Research
https://read.qxmd.com/read/38516543/the-association-between-dehydration-and-the-prognosis-of-sudden-sensorineural-hearing-loss
#24
JOURNAL ARTICLE
Yasunori Abe, Masahiro Okada, Keiko Tanaka, Kensuke Toyama, Yoshito Miyamoto, Naohito Hato
BACKGROUND: There is an urgent need to identify undetermined risk factors for sudden sensorineural hearing loss (SSNHL) for the development of effective treatment strategies. SSNHL is likely associated with vascular insufficiency; however, no study has evaluated the relationship between dehydration and SSNHL. OBJECTIVE: This study aimed to investigate the role of dehydration in the development and prognosis of sudden sensorineural hearing loss. STUDY DESIGN: Retrospective case-control study...
December 2023: Otol Neurotol Open
https://read.qxmd.com/read/38516175/primary-retroperitoneal-cavernous-hemangioma-a-case-report-and-review-of-the-literature
#25
Yuki Matsui, Sho Okada, Yoshihiro Nakagami, Takashi Fukagai, Kazuhiro Matsuda, Takeshi Aoki
Retroperitoneal cavernous hemangioma, a rare vascular tumor, has only 30 PubMed cases. Preoperative diagnostic criteria are unclear and often present asymptomatically until complications such as rupture or compression arise. We present a 73-year-old with chronic abdominal pain and a giant retroperitoneal tumor. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed an irregular space-occupying mass in the retroperitoneum, suggesting a retroperitoneal chronic expanding hematoma. Total surgical resection confirmed the diagnosis as retroperitoneal cavernous hemangioma...
May 2024: Urology Case Reports
https://read.qxmd.com/read/38515400/metabolic-syndrome-and-cardiovascular-disease-in-cancer-survivors
#26
JOURNAL ARTICLE
Kensuke Ueno, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Kentaro Kamiya, Junya Ako, Koichi Node, Hideo Yasunaga, Issei Komuro
BACKGROUND: The risk of subsequent cardiovascular disease (CVD) is high in cancer survivors. Although metabolic syndrome is an established risk factor for CVD, its association with cancer survivors has not yet been established. This study aimed to clarify whether metabolic syndrome is associated with subsequent CVD risk in patients with cancer using a nationwide epidemiological dataset. METHODS: We retrospectively analysed 53 510 patients with a history of breast, colorectal, or stomach cancer, which is reportedly a major site for developing cancer in Japan...
March 22, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38514734/dysphagia-in-patients-with-severe-covid-19-a-retrospective-study
#27
JOURNAL ARTICLE
Rie Asayama, Kaori Tanaka-Nishikubo, Masahiro Okada, Naoki Mukai, Suguru Annen, Hironori Matsumoto, Jun Takeba, Norio Sato, Naohito Hato
To investigate dysphagia after extubation in patients with severe coronavirus disease 2019 (COVID-19). We retrospectively examined patients with severe COVID-19 treated in our hospital between August 2021 and March 2022. Feeding outcomes were categorized into two groups-(1) total oral intake, and (2) difficulty in oral intake. To assess the feeding outcome, we used modified water-swallowing test (MWST) for all patients. However, in cases where aspiration or recurrent laryngeal nerve palsy was suspected, we conducted the fiberoptic endoscopic evaluation of swallowing after MWST...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514681/liver-resection-volume-dependent-pancreatic-strain-following-living-donor-hepatectomy
#28
JOURNAL ARTICLE
Taiichi Wakiya, Yasunaru Sakuma, Yasuharu Onishi, Yukihiro Sanada, Noriki Okada, Yuta Hirata, Toshio Horiuchi, Takahiko Omameuda, Kiichiro Takadera, Naohiro Sata
The liver and pancreas work together to recover homeostasis after hepatectomy. This study aimed to investigate the effect of liver resection volume on the pancreas. We collected clinical data from 336 living liver donors. They were categorized into left lateral sectionectomy (LLS), left lobectomy, and right lobectomy (RL) groups. Serum pancreatic enzymes were compared among the groups. Serum amylase values peaked on postoperative day (POD) 1. Though they quickly returned to preoperative levels on POD 3, 46% of cases showed abnormal values on POD 7 in the RL group...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38513985/omitting-lymph-node-dissection-for-small-ground-glass-opacity-dominant-tumors
#29
JOURNAL ARTICLE
Takahiro Mimae, Yoshihiro Miyata, Norifumi Tsubokawa, Yujin Kudo, Takuya Nagashima, Hiroyuki Ito, Norihiko Ikeda, Morihito Okada
BACKGROUND: The study purpose was to determine the optimal extent of lymph node dissection required in patients with small (≤ 3 cm) radiologically ground-glass opacity-dominant, peripheral, non-small cell lung cancer tumors. METHODS: We analyzed the clinicopathological findings/surgical outcomes of 988 patients with radiological, ground glass opacity-dominant non-small cell lung cancer without lymph node involvement who underwent complete resection of the primary tumor between 2010 and 2020...
March 19, 2024: Annals of Thoracic Surgery
https://read.qxmd.com/read/38513962/protein-phosphatase-4-mediates-palmitic-acid-induced-endothelial-dysfunction-by-decreasing-enos-phosphorylation-at-serine-633-in-huvecs
#30
JOURNAL ARTICLE
Zhengwei Liang, Gang Sun, Junshi Zhang, Qian Zhang, Xiaoyu Li, Si Qin, Sha Lv, Jing Ding, Qifang Zhang, Yong Xia, Deqin Lu
Plasma saturated free fatty acid (FFA)-induced endothelial dysfunction (ED) contributes to the pathogenesis of atherosclerosis and cardiovascular diseases. However, the mechanism underlying saturated FFA-induced ED remains unclear. This study demonstrated that palmitic acid (PA) induced ED by activating the NADPH oxidase (NOX)/ROS signaling pathway to activate protein phosphatase 4 (PP4) and protein phosphatase 2A (PP2A), thereby reducing endothelial nitric oxide synthase (eNOS) phosphorylation at Ser633 and Ser1177, respectively...
March 19, 2024: Experimental Cell Research
https://read.qxmd.com/read/38511865/renal-hemodynamic-and-functional-changes-in-adpkd-patients
#31
JOURNAL ARTICLE
Ryota Ishii, Hirayasu Kai, Kentaro Nakajima, Takuya Harada, Tomoki Akiyama, Eri Okada, Ryoya Tsunoda, Toshiaki Usui, Kaori Mase, Naoki Morito, Chie Saito, Joichi Usui, Kunihiro Yamagata
BACKGROUND: Although the mechanisms underlying cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) are becoming clearer, those of renal dysfunction are not fully understood. In particular, total kidney volume (TKV) and renal function do not always correspond. To elucidate this discrepancy, we studied in detail glomerular hemodynamic changes during ADPKD progression. METHODS: Sixty-one ADPKD patients with baseline height-adjusted TKV (Ht-TKV) of 933±537 ml/m and serum creatinine of 1...
March 21, 2024: Kidney360
https://read.qxmd.com/read/38511217/systematic-molecular-analyses-for-115-karyotypically-normal-men-with-isolated-non-obstructive-azoospermia
#32
JOURNAL ARTICLE
Yuki Muranishi, Yoshitomo Kobori, Yuko Katoh-Fukui, Satoshi Tamaoka, Atsushi Hattori, Akiyoshi Osaka, Hiroshi Okada, Kazuhiko Nakabayashi, Kenichiro Hata, Tomoko Kawai, Hiroko Ogata-Kawata, Toshiyuki Iwahata, Kazuki Saito, Masafumi Kon, Nobuo Shinohara, Maki Fukami
STUDY QUESTION: Do copy-number variations (CNVs) in the azoospermia factor (AZF) regions and monogenic mutations play a major role in the development of isolated (non-syndromic) non-obstructive azoospermia (NOA) in Japanese men with a normal 46, XY karyotype? SUMMARY ANSWER: Deleterious CNVs in the AZF regions and damaging sequence variants in eight genes likely constitute at least 8% and approximately 8% of the genetic causes, respectively, while variants in other genes play only a minor role...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38511087/pharmacokinetics-safety-and-efficacy-of-20-subcutaneous-immunoglobulin-ig20gly-administered-weekly-or-every-2-weeks-in-japanese-patients-with-primary-immunodeficiency-diseases-a-phase-3-open-label-study
#33
JOURNAL ARTICLE
Hirokazu Kanegane, Akifumi Endo, Satoshi Okada, Hidenori Ohnishi, Masataka Ishimura, Ryuta Nishikomori, Kohsuke Imai, Shigeaki Nonoyama, Hideki Muramatsu, Taizo Wada, Atsushi Kuga, Ko Sakamoto, Sharon Russo-Schwarzbaum, Liang-Hui Chu, Barbara McCoy, Zhaoyang Li, Leman Yel
This phase 3, open-label, multidose study (NCT04346108) evaluated the pharmacokinetics, safety, tolerability, and efficacy of immunoglobulin subcutaneous (human) 20% solution (Ig20Gly) administered weekly and every 2 weeks in Japanese patients with primary immunodeficiency diseases (PIDs). The study was conducted at eight study sites in Japan and enrolled patients aged ≥2 years with PIDs treated using a stable intravenous immunoglobulin dose for ≥3 months prior to the study. Patients received intravenous immunoglobulin every 3 or 4 weeks at pre-study dose (200-600 mg/kg) for 13 weeks (Epoch 1), subcutaneous Ig20Gly (50-200 mg/kg) once weekly for 24 weeks (Epoch 2), and Ig20Gly (100-400 mg/kg) every 2 weeks for 12 weeks (Epoch 3)...
2024: Immunotherapy advances
https://read.qxmd.com/read/38511074/individual-acute-phase-bleeding-and-thrombotic-risk-balance-assessment-in-patients-undergoing-percutaneous-coronary-intervention-for-acute-myocardial-infarction
#34
JOURNAL ARTICLE
Yohei Sotomi, Shungo Hikoso, Sho Komukai, Tetsuhisa Kitamura, Daisaku Nakatani, Tomoharu Dohi, Hiroya Mizuno, Katsuki Okada, Hirota Kida, Bolrathanak Oeun, Akihiro Sunaga, Taiki Sato, Yuki Matsuoka, Yasuhiko Sakata, Hiroshi Sato, Masatsugu Hori, Issei Komuro, Yasushi Sakata
BACKGROUND: Individualized treatment approach based on pre-procedural precise risk balance assessment between bleeding and thrombosis would be desirable for patients with myocardial infarction (MI) undergoing emergent percutaneous coronary intervention (PCI) in this ultra-short dual antiplatelet therapy era. We aimed to develop and validate a quick thrombosis/bleeding risk-balance assessment tool. METHODS: We developed and validated a novel thrombosis/bleeding risk-balance assessment tool using individual patient data from the prospective multicenter MI registry...
April 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38509476/correction-pathologic-tonsillar-findings-similar-to-iga-nephropathy-and-the-role-of-tonsillectomy-in-a-patient-with-nephrotic-syndrome
#35
Takuji Enya, Tomoki Miyazawa, Kohei Miyazaki, Rina Oshima, Yuichi Morimoto, Mitsuru Okada, Tsukasa Takemura, Keisuke Sugimoto
No abstract text is available yet for this article.
March 20, 2024: BMC Nephrology
https://read.qxmd.com/read/38508724/development-of-an-auraptene-loaded-transdermal-formulation-using-non-ionic-sugar-ester-surfactants
#36
JOURNAL ARTICLE
Kathrine Anne Flores, Akie Okada, Florencio Arce, Gerard Lee See, Shoko Itakura, Hiroaki Todo, Kenji Sugibayashi
Auraptene (Aur) is a naturally occurring monoterpene coumarin ether that exhibits numerous therapeutic properties. Its high lipophilicity and low skin penetration, however, limit its potential application for local and transdermal delivery. Biocompatible non-ionic sugar esters (SEs) possess beneficial properties for the development of transdermal formulations in delivering pharmaceutically challenging molecules such as graphene and Aur. In the present study, we conducted a series of experiments to demonstrate the effect of several previously unstudied SEs on the skin permeation and distribution of Aur by preparing gel- and dispersion-type formulations...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38507671/epitope-mapping-of-an-anti-mouse-cd39-monoclonal-antibody-using-pa-scanning-and-riedl-scanning
#37
JOURNAL ARTICLE
Yuki Okada, Hiroyuki Suzuki, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato
A cell-surface ectonucleotidase CD39 mediates the conversion of extracellular adenosine triphosphate into immunosuppressive adenosine with another ectonucleotidase CD73. The elevated adenosine in the tumor microenvironment attenuates antitumor immunity, which promotes tumor cell immunologic escape and progression. Anti-CD39 monoclonal antibodies (mAbs), which suppress the enzymatic activity, can be applied to antitumor therapy. Therefore, an understanding of the relationship between the inhibitory activity and epitope of mAbs is important...
March 20, 2024: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://read.qxmd.com/read/38506982/association-of-serum-magnesium-levels-with-renal-prognosis-in-patients-with-chronic-kidney-disease
#38
JOURNAL ARTICLE
Seiji Kishi, Takaya Nakashima, Tadahiro Goto, Hajime Nagasu, Craig R Brooks, Hirokazu Okada, Kouichi Tamura, Toshiaki Nakano, Ichiei Narita, Shoichi Maruyama, Yuichiro Yano, Takashi Yokoo, Takashi Wada, Jun Wada, Masaomi Nangaku, Naoki Kashihara
BACKGROUND: Magnesium deficiency is associated with various health conditions, but its impact on the progression of chronic kidney disease (CKD) remains unclear. This study aimed to investigate the association between serum magnesium levels and prognosis of renal function in CKD patients. METHODS: This is an analysis of the Japan Chronic Kidney Disease Database Ex (J-CKD-DB-Ex), which is a multicenter prospective cohort including CKD patients enrolled from January 1, 2014 to December 31, 2020...
March 20, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38505714/the-gonio-scratch-study-methodology-of-a-multicenter-clinical-trial-establishing-a-new-minimally-invasive-glaucoma-surgery
#39
MULTICENTER STUDY
Kana Tokumo, Naoki Okada, Tsukasa Mochizuki, Hiromitsu Onoe, Kaori Komatsu, Hideaki Okumichi, Kazuyuki Hirooka, Hideki Mochizuki, Mitsunobu Yokoyama, Yoshiaki Kiuchi
There are numerous surgical procedures for glaucoma. Minimally invasive glaucoma surgery is becoming popular; however, the disadvantage is the high incidence of anterior chamber hemorrhage. Heavy bleeding can also lead to increased intraocular pressure (IOP) postoperatively. Gonio scratch is a surgical procedure that improves aqueous humor outflow by rubbing off deposits on the trabecular meshwork with a Diamond Dusted Sweeper. As the conjunctiva and trabecular meshwork are not incised, no postoperative bleeding is expected, and the IOP spike will be minimal...
February 2024: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38505713/%C3%AF-editors-choice%C3%AF-the-relationship-between-preoperative-foot-alignment-and-postoperative-outcomes-in-patients-who-underwent-initial-total-knee-arthroplasty
#40
JOURNAL ARTICLE
Aika Hishida, Hideki Hiraiwa, Izumi Kadono, Hidetoshi Yamaguchi, Takashi Okada, Chiaki Terai, Azusa Kayamoto, Yoshihiro Nishida
We compared the relationship between foot alignments and quality of life in patients who underwent initial total knee arthroplasty (TKA). Among the patients with knee osteoarthritis (KOA) who underwent TKA from May 2015 to May 2017 at our hospital, we focused on those in whom weight-bearing foot radiographs had been evaluated preoperatively. The hallux valgus angle and Meary angle were measured by preoperative radiography, and those with hallux valgus angles of 20 degrees or more were classified into the hallux valgus (HV) group, and those with Meary angles of 4 degrees or more into the high arch (HA) group...
February 2024: Nagoya Journal of Medical Science
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