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https://www.readbyqxmd.com/read/29352126/role-of-subcortical-structures-on-cognitive-and-social-function-in-schizophrenia
#1
Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kazutaka Ohi, Haruo Fujino, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimoto
Subcortical regions have a pivotal role in cognitive, affective, and social functions in humans, and the structural and functional abnormalities of the regions have been associated with various psychiatric disorders. Although previous studies focused on the neurocognitive and socio-functional consequences of prefrontal and tempolo-limbic abnormalities in psychiatric disorders, those of subcortical structures remain largely unknown. Recently, MRI volume alterations in subcortical structures in patients with schizophrenia have been replicated in large-scale meta-analytic studies...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351704/safety-of-cold-snare-polypectomy-for-duodenal-adenomas-in-familial-adenomatous-polyposis-a-prospective-exploratory-study
#2
Kenta Hamada, Yoji Takeuchi, Hideki Ishikawa, Yasumasa Ezoe, Masamichi Arao, Sho Suzuki, Taro Iwatsubo, Minoru Kato, Yusuke Tonai, Satoki Shichijo, Yasushi Yamasaki, Noriko Matsuura, Hiroko Nakahira, Takashi Kanesaka, Sachiko Yamamoto, Tomofumi Akasaka, Noboru Hanaoka, Koji Higashino, Noriya Uedo, Ryu Ishihara, Hiroyuki Okada, Hiroyasu Iishi
BACKGROUND:  Cold snare polypectomy (CSP) to remove multiple duodenal adenomas (MDAs) in patients with familial adenomatous polyposis (FAP) could be an effective and less invasive method than more extensive surgery. The aim of the present study was to determine the safety of this procedure. METHODS:  This prospective exploratory study included 10 consecutive patients with FAP and MDAs who underwent CSP for as many as 50 duodenal adenomas. The primary outcome was the incidence of severe adverse events...
January 19, 2018: Endoscopy
https://www.readbyqxmd.com/read/29351284/magnetic-resonance-angiography-with-compressed-sensing-an-evaluation-of-moyamoya-disease
#3
Takayuki Yamamoto, Tomohisa Okada, Yasutaka Fushimi, Akira Yamamoto, Koji Fujimoto, Sachi Okuchi, Hikaru Fukutomi, Jun C Takahashi, Takeshi Funaki, Susumu Miyamoto, Aurélien F Stalder, Yutaka Natsuaki, Peter Speier, Kaori Togashi
Compressed sensing (CS) reconstructions of under-sampled measurements generate missing data based on assumptions of image sparsity. Non-contrast time-of-flight MR angiography (TOF-MRA) is a good candidate for CS based acceleration, as MRA images feature bright trees of sparse vessels over a well-suppressed anatomical background signal. A short scan time derived from CS is beneficial for patients of moyamoya disease (MMD) because of the frequency of MR scans. The purpose of this study was to investigate the reliability of TOF-MRA with CS in the evaluation of MMD...
2018: PloS One
https://www.readbyqxmd.com/read/29347923/endoscopic-balloon-dilatation-for-benign-hepaticojejunostomy-anastomotic-stricture-using-short-double-balloon-enteroscopy-in-patients-with-a-prior-whipple-s-procedure-a-retrospective-study
#4
Sho Mizukawa, Koichiro Tsutsumi, Hironari Kato, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Takeshi Tomoda, Shigeru Horiguchi, Hiroyuki Okada
BACKGROUND: Endoscopic retrograde cholangiography using a short double-balloon endoscope (DB-ERC) is a promising minimally-invasive method for accessing hepaticojejunostomy (HJ) anastomosis in patients with surgically altered anatomy. We aimed to evaluate the immediate and long-term outcomes of balloon dilatation for benign HJ anastomotic stricture (HJAS) in patients who had previously undergone Whipple's procedure using a DB-ERC. METHODS: We conducted a retrospective analysis of 46 patients who underwent balloon dilatation alone with a DB-ERC for benign HJAS between November 2008 and November 2014...
January 18, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29346770/integrative-analyses-of-de-novo-mutations-provide-deeper-biological-insights-into-autism-spectrum-disorder
#5
Atsushi Takata, Noriko Miyake, Yoshinori Tsurusaki, Ryoko Fukai, Satoko Miyatake, Eriko Koshimizu, Itaru Kushima, Takashi Okada, Mako Morikawa, Yota Uno, Kanako Ishizuka, Kazuhiko Nakamura, Masatsugu Tsujii, Takeo Yoshikawa, Tomoko Toyota, Nobuhiko Okamoto, Yoko Hiraki, Ryota Hashimoto, Yuka Yasuda, Shinji Saitoh, Kei Ohashi, Yasunari Sakai, Shouichi Ohga, Toshiro Hara, Mitsuhiro Kato, Kazuyuki Nakamura, Aiko Ito, Chizuru Seiwa, Emi Shirahata, Hitoshi Osaka, Ayumi Matsumoto, Saoko Takeshita, Jun Tohyama, Tomoko Saikusa, Toyojiro Matsuishi, Takumi Nakamura, Takashi Tsuboi, Tadafumi Kato, Toshifumi Suzuki, Hirotomo Saitsu, Mitsuko Nakashima, Takeshi Mizuguchi, Fumiaki Tanaka, Norio Mori, Norio Ozaki, Naomichi Matsumoto
Recent studies have established important roles of de novo mutations (DNMs) in autism spectrum disorders (ASDs). Here, we analyze DNMs in 262 ASD probands of Japanese origin and confirm the "de novo paradigm" of ASDs across ethnicities. Based on this consistency, we combine the lists of damaging DNMs in our and published ASD cohorts (total number of trios, 4,244) and perform integrative bioinformatics analyses. Besides replicating the findings of previous studies, our analyses highlight ATP-binding genes and fetal cerebellar/striatal circuits...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29344123/ex-vivo-model-of-non-small-cell-lung-cancer-using-mouse-lung-epithelial-cells
#6
Taku Sato, Mami Morita, Ryota Tanaka, Yui Inoue, Miyuki Nomura, Yoshimi Sakamoto, Koh Miura, Shigemi Ito, Ikuro Sato, Nobuyuki Tanaka, Jiro Abe, Satomi Takahashi, Masaaki Kawai, Masami Sato, Yoshitaka Hippo, Hiroshi Shima, Yoshinori Okada, Nobuhiro Tanuma
Lung cancer is the most common cause of cancer mortality, however, efficient methods to culture, expand and transform lung epithelial (LE) cells have not been established. In the present study, an efficient ex vivo method was applied to recapitulate lung carcinogenesis using mouse LE cells. A Matrigel-assisted three-dimensional culture was used to isolate and selectively expand LE cells from mouse lungs. Purified LE cells were passaged and expanded for at least 2 to 3 months while maintaining epidermal growth factor-dependence...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29339204/serum-uric-acid-and-prevalence-of-age-related-hearing-loss-in-the-japanese-population-baseline-data-from-the-aidai-cohort-study-in-yawatahama
#7
Daiki Takagi, Shinya Furukawa, Masahiro Okada, Keiko Tanaka, Hidenori Senba, Masato Teraoka, Hiroyuki Yamada, Naohito Hato, Yoshihiro Miyake
AIMS: Metabolic diseases may affect age-related hearing loss (AHL). Only one epidemiological study showed a positive association between serum uric acid levels and AHL. The aim of this study was to estimate this issue in Japanese men and women. METHODS: Study subjects were 694 individuals aged 36-76 years. A self-administered questionnaire was used to collect information on the variables under study. Audiological assessment was performed using pure-tone audiometry...
January 12, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29337775/comparisons-of-rigid-proctoscopy-flexible-colonoscopy-and-digital-rectal-examination-for-determining-the-localization-of-rectal-cancers
#8
Akira Tanaka, Sotaro Sadahiro, Toshiyuki Suzuki, Kazutake Okada, Gota Saito
BACKGROUND: Rigid proctoscopy is considered essential for rectal tumor localization, although the current gold standard for detection of colorectal cancers is colonoscopy. The European Society for Medical Oncology Guidelines indicate that rigid and flexible endoscopies afford essentially identical results, although little evidence is yet available to support this. OBJECTIVE: The purpose of this study was to determine the accuracy of colonoscopy in identifying the location of rectal cancer and to compare the results with those of rigid proctoscopy and digital rectal examination...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337425/distinct-gene-expression-profiles-and-regulation-networks-of-nasal-polyps-in-eosinophilic-and-non-eosinophilic-chronic-rhinosinusitis
#9
Naoko Okada, Tsuguhisa Nakayama, Daiya Asaka, Natsuki Inoue, Tadao Tsurumoto, Shinya Takaishi, Nobuyoshi Otori, Hiromi Kojima, Akio Matsuda, Keisuke Oboki, Hirohisa Saito, Kenji Matsumoto, Mamoru Yoshikawa
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2 phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia and easily recurrent, is distinguished from other non-eosinophilic CRSwNP (NECRSwNP) types. However, the pathogenesis of each remains unclear. METHODS: Nasal polyp tissues from ECRS (ECRSwNP) and NECRS (NECRSwNP) patients were obtained, and their comprehensive gene expression profiles were investigated by microarray analysis...
January 16, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29337353/consumer-acceptance-comparison-between-seasoned-and-unseasoned-vegetables
#10
Yiming Feng, Marta Albiol Tapia, Kyle Okada, Nuria Blanca Castaneda Lazo, Karen Chapman-Novakofski, Carter Phillips, Soo-Yeun Lee
Recent findings show that approximately 87% of the U.S. population fail to meet the vegetable intake recommendations, with unpleasant taste of vegetables being listed as the primary reason for this shortfall. In this study, spice and herb seasoning was used to enhance palatability of vegetables, in order to increase consumer acceptance. In total, 749 panelists were screened and recruited as specific vegetable likers of the vegetable being tested or general vegetable likers. Four sessions were designed to evaluate the effect of seasoning within each type of vegetable, including broccoli, cauliflower, carrot, and green bean...
January 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29336469/transcriptional-regulation-of-hiv-1-host-factor-commd1-by-the-sp-family
#11
Eriko Kudo, Manabu Taura, Mary Ann Suico, Hiroki Goto, Hirofumi Kai, Seiji Okada
Copper metabolism Murr1 domain containing 1 (COMMD1) has multiple functions in the regulation of protein stability at the plasma membrane and in the cytoplasm. However, the regulation of COMMD1 transcriptional has remained to be elucidated. In the present study, the 5'‑flanking region (‑1,192/+83 bp) of the human COMMD1 gene was cloned. It was observed that the COMMD1 promoter region contains GC‑rich region that has 7 putative Sp1‑binding sites via in silico analysis. The proximal promoter region at ‑289/+83 bp was required for COMMD1 basal promoter activity by deletion constructs of COMMD1 promoter...
January 15, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29336057/modification-of-lymphocyte-migration-to-peyer-s-patches-by-inhibition-of-sphingosine-1-phosphate-lyase-ameliorates-murine-colitis
#12
Kazuhiko Shirakabe, Masaaki Higashiyama, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Masayuki Saruta, Ryota Hokari
BACKGROUND AND AIM: Sphingosine-1-phosphate (S1P) receptor 1, a therapeutic target of the S1P1 agonist FTY720, plays a crucial role in lymphocyte migration and is expressed in several cells including naïve T lymphocytes and endothelial cells. 2-acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase (SPL), exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear. We aimed to clarify how THI affects colitis and migration of naïve T lymphocytes in Peyer's patches (PPs)...
January 15, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29335272/complementary-value-of-cardiac-magnetic-resonance-imaging-and-positron-emission-tomography-computed-tomography-in-the-assessment-of-cardiac-sarcoidosis
#13
Tomas Vita, David R Okada, Mahdi Veillet-Chowdhury, Paco E Bravo, Erin Mullins, Edward Hulten, Mukta Agrawal, Rachna Madan, Viviany R Taqueti, Michael Steigner, Hicham Skali, Raymond Y Kwong, Garrick C Stewart, Sharmila Dorbala, Marcelo F Di Carli, Ron Blankstein
BACKGROUND: Although cardiac magnetic resonance (CMR) and positron emission tomography (PET) detect different pathological attributes of cardiac sarcoidosis (CS), the complementary value of these tests has not been evaluated. Our objective was to determine the value of combining CMR and PET in assessing the likelihood of CS and guiding patient management. METHODS AND RESULTS: In this retrospective study, we included 107 consecutive patients referred for evaluation of CS by both CMR and PET...
January 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29334399/chondrocyte-burst-promotes-space-for-mineral-expansion
#14
Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Letycia Mary Iida, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto
Analysis of tissue development from multidisciplinary approaches can result in more integrative biological findings, and can eventually allow the development of more effective bioengineering methods. In this study, we analyzed the initial steps of mineral formation during secondary ossification of mouse femur based on biological and bioengineering approaches. We first found that some chondrocytes burst near the mineralized area. External factors that could trigger chondrocyte burst were then investigated. Chondrocyte burst was shown to be modulated by mechanical and osmotic pressure...
January 15, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29334327/migration-of-a-kirschner-wire-into-the-spinal-cord-a-case-report-and-literature-review
#15
Ryogo Furuhata, Mitsuhiro Nishida, Midori Morishita, Shigeru Yanagimoto, Masaki Tezuka, Eijiro Okada
CONTEXT: A Kirschner wire (K-wire) is a stainless steel pin with at least one sharpened tip that is mainly used for the internal fixation of bone fractures. While some cases of K-wire dislocation and migration have been reported as complications after fracture surgery, the intraspinal migration of a K-wire is rare. Herein, we report a case in which a K-wire used for sternal fixation 7 years earlier migrated into the spinal canal. FINDINGS: A 68-year-old male suddenly sustained severe radiating pain and numbness in his left upper extremity, and walked to our hospital...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29334036/short-term-storage-of-the-oocytes-affects-the-ploidy-status-in-the-yellowtail-tetra-astyanax-altiparanae
#16
Matheus Pereira Dos Santos, Nivaldo Ferreira do Nascimento, George Shigueki Yasui, Nycolas Levy Pereira, Takafumi Fujimoto, José Augusto Senhorini, Laura Satiko Okada Nakaghi
In fish, many factors can affect reproduction during in vitro fertilization, therefore determination of the factors that affect affecting gamete quality is needed. However, few studies have focused on gamete quality and the ploidy status. This study was conducted to elucidate whether oocyte storage can affect ploidy status, survival, and embryo viability in the characid species Astyanax altiparanae. Oocytes were stored in Dulbecco's phosphate-buffered saline (PBS) at 26°C, then aliquots were fertilized immediately after extrusion (control) and also after 60, 120, 180, and 240 min of storage...
January 15, 2018: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29333077/underwater-endoclip-closure-after-endoscopic-resection-for-duodenal-adenomas
#17
Yasushi Yamasaki, Hiromitsu Kanzaki, Yoshiro Kawahara, Hiroyuki Okada
No abstract text is available yet for this article.
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29330857/reduction-of-hyaluronan-and-increased-expression-of-hybid-kiaa1199-correlate-with-clinical-symptoms-in-photoaged-skin
#18
H Yoshida, A Nagaoka, A Komiya, M Aoki, S Nakamura, T Morikawa, R Ohtsuki, T Sayo, Y Okada, Y Takahashi
BACKGROUND: Hyaluronan (HA) metabolism in skin fibroblasts is mediated by HYBID (HYaluronan Binding protein Involved in hyaluronan Depolymerisation, KIAA1199) and HA synthases 1/2 (HAS1/2). However, photoageing-dependent changes in HA and their molecular mechanisms, and the relationship between HA metabolism and clinical symptoms in photoaged skin remain elusive. OBJECTIVES: We examined amount, size and tissue distribution of HA and expression levels of HYBID and HAS1/2 in photoaged skin, and analysed their relationships to the degree of photoageing...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330411/x-ray-induced-scintillation-governed-by-energy-transfer-process-in-glasses
#19
Hirokazu Masai, Go Okada, Aya Torimoto, Takaaki Usui, Noriaki Kawaguchi, Takayuki Yanagida
The efficiency of X-ray-induced scintillation in glasses roughly depends on both the effective atomic number Zeff and the photoluminescence quantum efficiency Qeff of glass, which are useful tools for searching high-performance phosphors. Here, we demonstrate that the energy transfer from host to activators is also an important factor for attaining high scintillation efficiency in Ce-doped oxide glasses. The scintillation intensity of glasses with coexisting fractions of Ce3+ and Ce4+ species is found to be higher than that of a pure-Ce3+-containing glass with a lower Zeff value...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329989/reassessment-of-right-middle-lobe-lung-cancer-comparison-of-segments-4-and-5-tumors
#20
Yoshinori Handa, Yasuhiro Tsutani, Takuhiro Ikeda, Hideaki Hanaki, Yoshihiro Miyata, Hidenori Mukaida, Morihito Okada
BACKGROUND: The purpose of this study is to elucidate the clinical behavior of right middle lobe lung cancer, with focus on the tumor location. METHODS: We reviewed retrospectively 711 patients who underwent lobectomy or bilobectomy for clinical stage I non-small cell lung cancer (upper lobe, 346; middle lobe, 82; lower lobe, 283). Factors affecting survival were assessed by log-rank tests and Cox regression analyses. RESULTS: The prognosis of patients with segment 5 tumors (n = 39) was significantly worse than that of patients with segment 4 tumors (n = 43; 5-year overall survival [OS] rates, 69...
January 9, 2018: Annals of Thoracic Surgery
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