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https://www.readbyqxmd.com/read/29161703/expression-profile-of-notch3-in-mouse-spermatogonia
#1
Ryu Okada, Megumi Fujimagari, Eri Koya, Yoshikazu Hirose, Tomomi Sato, Yukio Nishina
Stable and sustainable spermatogenesis is supported by the strict regulation of self-renewal and differentiation of spermatogonial stem cells (SSC), which are a rare population of undifferentiated spermatogonia. It has been revealed that some signaling factors regulate the self-renewal of SSC; however, the molecular mechanism of SSC maintenance is still not completely understood. Notch signaling is an evolutionarily conserved juxtacrine signaling that plays important roles in the cell fate determination of various tissue stem cells...
January 22, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29161247/errata-functional-annotation-of-chemical-libraries-across-diverse-biological-processes
#2
Jeff S Piotrowski, Sheena C Li, Raamesh Deshpande, Scott W Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A Gebre, Karen Kubo, Nikko P Torres, Marissa A LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L Myers, Charles Boone
This corrects the article DOI: 10.1038/nchembio.2436.
November 21, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29161244/errata-functional-annotation-of-chemical-libraries-across-diverse-biological-processes
#3
Jeff S Piotrowski, Sheena C Li, Raamesh Deshpande, Scott W Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A Gebre, Karen Kubo, Nikko P Torres, Marissa A LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L Myers, Charles Boone
This corrects the article DOI: 10.1038/nchembio.2436.
November 21, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29160014/loss-of-tenascin-x-gene-function-impairs-injury-induced-stromal-angiogenesis-in-mouse-corneas
#4
Takayoshi Sumioka, Hiroki Iwanishi, Yuka Okada, Yuka Nidegawa, Masayasu Miyajima, Ken-Ichi Matsumoto, Shizuya Saika
To determine the contribution by tenascin X (Tnx) gene expression to corneal stromal angiogenesis, the effects were determined of its loss on this response in TNX knockout (KO) mice. In parallel, the effects of such a loss were evaluated on vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGFβ1) gene and protein expression in fibroblasts and macrophages in cell culture. Histological, immunohistochemical and quantitative RT-PCR changes determined if Tnx gene ablation on angiogenic gene expression, inflammatory cell infiltration and neovascularization induced by central corneal stromal cauterization...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29159276/linked-color-imaging-lci-a-novel-image-enhanced-endoscopy-technology-emphasizes-the-color-of-early-gastric-cancer
#5
Hiromitsu Kanzaki, Ryuta Takenaka, Yoshiro Kawahara, Daisuke Kawai, Yuka Obayashi, Yuki Baba, Hiroyuki Sakae, Tatsuhiro Gotoda, Yoshiyasu Kono, Ko Miura, Masaya Iwamuro, Seiji Kawano, Takehiro Tanaka, Hiroyuki Okada
Background and study aims:  Linked color imaging (LCI) and blue laser imaging (BLI) are novel image-enhanced endoscopy technologies with strong, unique color enhancement. We investigated the efficacy of LCI and BLI-bright compared to conventional white light imaging (WLI) by measuring the color difference between early gastric cancer lesions and the surrounding mucosa. Patients and methods:  Images of early gastric cancer scheduled for endoscopic submucosal dissection were captured by LCI, BLI-bright, and WLI under the same conditions...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29159266/analysis-of-macrolinguistic-aspects-of-narratives-from-individuals-with-alzheimer-s-disease-mild-cognitive-impairment-and-no-cognitive-impairment
#6
Cíntia Matsuda Toledo, Sandra Maria Aluísio, Leandro Borges Dos Santos, Sonia Maria Dozzi Brucki, Eduardo Sturzeneker Trés, Maira Okada de Oliveira, Letícia Lessa Mansur
Introduction: The depiction of features in discourse production promotes accurate diagnosis and helps to establish the therapeutic intervention in cognitive impairment and dementia. We aimed to identify alterations in the macrolinguistic aspects of discourse using a new computational tool. Methods: Sixty individuals, aged 60 years and older, were distributed in three different groups: mild Alzheimer's disease (mAD), amnestic mild cognitive impairment, and healthy controls...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29158492/structural-basis-for-the-assembly-of-the-ragulator-rag-gtpase-complex
#7
Ryo Yonehara, Shigeyuki Nada, Tomokazu Nakai, Masahiro Nakai, Ayaka Kitamura, Akira Ogawa, Hirokazu Nakatsumi, Keiichi I Nakayama, Songling Li, Daron M Standley, Eiki Yamashita, Atsushi Nakagawa, Masato Okada
The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in regulating cell growth and metabolism by responding to cellular nutrient conditions. The activity of mTORC1 is controlled by Rag GTPases, which are anchored to lysosomes via Ragulator, a pentameric protein complex consisting of membrane-anchored p18/LAMTOR1 and two roadblock heterodimers. Here we report the crystal structure of Ragulator in complex with the roadblock domains of RagA-C, which helps to elucidate the molecular basis for the regulation of Rag GTPases...
November 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29158173/standardized-and-simplified-retroperitoneal-lymph-node-dissection-during-retroperitoneal-laparoscopic-radical-nephroureterectomy-for-urothelial-carcinoma-of-the-upper-ureter-or-renal-pelvis-en-bloc-resection-technique
#8
Toru Kanno, Go Kobori, Masashi Kubota, Satoshi Funada, Takao Haitani, Takashi Okada, Yoshihito Higashi, Seiji Moroi, Hitoshi Yamada
OBJECTIVE To describe our en-bloc technique of retroperitoneal lymph node dissection (RPLND) during retroperitoneal laparoscopic radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC) and evaluate perioperative outcomes. METHODS From 2002 to 2015, 114 patients with UTUC located at the pelvis and/or upper or middle ureter underwent retroperitoneal laparoscopic RNU at two institutions. Performance of RPLND began in February 2009. The template of RPLND included the renal hilar and para-aortic lymph nodes (left side) and the renal hilar, paracaval, retrocaval, and intra-aortocaval lymph nodes (right side)...
November 17, 2017: Urology
https://www.readbyqxmd.com/read/29157745/differential-diagnosis-of-parkinsonian-syndromes-using-dopamine-transporter-and-perfusion-spect
#9
Shigetoshi Takaya, Nobukatsu Sawamoto, Tomohisa Okada, Gosuke Okubo, Sei Nishida, Kaori Togashi, Hidenao Fukuyama, Ryosuke Takahashi
OBJECTIVE: We aimed to assess whether a combined analysis of dopamine transporter (DAT)- and perfusion-SPECT images (or either) could: (1) distinguish atypical parkinsonian syndromes (APS) from Lewy body diseases (LBD; majority Parkinson disease [PD]), and (2) differentiate among APS subgroups (progressive supranuclear palsy [PSP], corticobasal syndrome [CBS], and multiple system atrophy [MSA]). METHODS: We recruited consecutive patients with neurodegenerative parkinsonian syndromes (LBD, n = 46; APS, n = 33)...
November 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29157132/in-planta-functions-of-cytochrome-p450-monooxygenase-genes-in-the-phytocassane-biosynthetic-gene-cluster-on-rice-chromosome-2
#10
Zhongfeng Ye, Kohei Yamazaki, Hiromi Minoda, Koji Miyamoto, Sho Miyazaki, Hiroshi Kawaide, Arata Yajima, Hideaki Nojiri, Hisakazu Yamane, Kazunori Okada
In response to environmental stressors such as blast fungal infections, rice produces phytoalexins, an antimicrobial diterpenoid compound. Together with momilactones, phytocassanes are among the major diterpenoid phytoalexins. The biosynthetic genes of diterpenoid phytoalexin are organized on the chromosome in functional gene clusters, comprising diterpene cyclase, dehydrogenase, and cytochrome P450 monooxygenase genes. Their functions have been studied extensively using in vitro enzyme assay systems. Specifically, P450 genes (CYP71Z6, Z7; CYP76M5, M6, M7, M8) on rice chromosome 2 have multifunctional activities associated with ent-copalyl diphosphate-related diterpene hydrocarbons, but the in planta contribution of these genes to diterpenoid phytoalexin production remains unknown...
November 20, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29155724/generation-of-a-gene-disrupted-streptococcus-mutans-strain-without-gene-cloning
#11
Takatoshi Murata, Ayako Okada, Khairul Matin, Nobuhiro Hanada
Typical methods for the elucidation of the function of a particular gene involve comparative phenotypic analyses of the wild-type strain and a strain in which the gene of interest has been disrupted. A gene-disruption DNA construct containing a suitable antibiotic resistance marker gene is useful for the generation of gene-disrupted strains in bacteria. However, conventional construction methods, which require gene cloning steps, involve complex and time-consuming protocols. Here, a relatively facile, rapid, and cost-effective method for targeted gene disruption in Streptococcus mutans is described...
October 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29154826/w9-peptide-enhanced-osteogenic-differentiation-of-human-adipose-derived-stem-cells
#12
Yuki Otsuki, Masaaki Ii, Kazumasa Moriwaki, Masashi Okada, Koichi Ueda, Michio Asahi
W9 is a peptide that abrogates osteoclast differentiation via blockade of nuclear factor-κB ligand (RANKL)-RANK signaling, which activates bone formation. However, W9 stimulated osteogenesis in osteoblasts and mesenchymal stem cells. The present study demonstrated that the W9 peptide promoted osteogenic differentiation of human adipose-derived stem cells (hAdSCs) even under non-osteogenic differentiation culture conditions. W9-treated hAdSCs exhibited several osteocalcin-expressing cells and great mineralization compared to the BMP2-treated hAdSCs, which suggests that the W9 peptide had potent osteogenic potential in hAdSCs...
November 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29154805/the-effects-of-imaginary-voluntary-muscle-contraction-and-relaxation-on-cerebellar-brain-inhibition
#13
Hiroaki Tanaka, Akiyoshi Matsugi, Yohei Okada
The purpose of this study was to investigate cerebellar brain inhibition (CBI) of the contralateral primary motor cortex (M1) during imaginary muscle contraction (Contract-I) and relaxation (Relax-I) using transcranial magnetic stimulation (TMS). Twenty-nine healthy adults completed two experiments. Motor evoked potentials (MEPs) in the right first dorsal interosseous (FDI) muscle were induced by TMS over the left M1 and measured with or without TMS over the right cerebellum during Contract-I (first experiment) and Relax-I (second experiment) of the right FDI, and these were compared to the findings in a no-imagery (No-I) condition...
November 14, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29154429/contrast-enhanced-computed-tomography-with-myocardial-three-dimensional-printing-can-guide-treatment-in-symptomatic-hypertrophic-obstructive-cardiomyopathy
#14
Yasuhiro Hamatani, Makoto Amaki, Hideaki Kanzaki, Kizuku Yamashita, Yasuteru Nakashima, Atsushi Shibata, Atsushi Okada, Hiroyuki Takahama, Takuya Hasegawa, Yusuke Shimahara, Yasuo Sugano, Tomoyuki Fujita, Isao Shiraishi, Satoshi Yasuda, Junjiro Kobayashi, Toshihisa Anzai
Both surgical myectomy and percutaneous transluminal septal myocardial ablation are effective treatments for drug-refractory symptomatic hypertrophic obstructive cardiomyopathy (HOCM). However, in some cases, it is not easy to elucidate the abnormal structure of left ventricular outflow obstruction to adopt these treatments. Here, we presented a young female patient with drug-refractory symptomatic HOCM. In this case, contrast-enhanced computed tomography enabled us to assess the suitability of percutaneous transluminal septal myocardial ablation...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153701/is-distal-pancreatectomy-with-en-bloc-celiac-axis-resection-effective-for-patients-with-locally-advanced-pancreatic-ductal-adenocarcinoma-multicenter-surgical-group-study
#15
Tomohisa Yamamoto, Sohei Satoi, Manabu Kawai, Fuyuhiko Motoi, Masayuki Sho, Ken-Ichiro Uemura, Ippei Matsumoto, Goro Honda, Ken-Ichi Okada, Takahiro Akahori, Hirochika Toyama, Masanao Kurata, Hiroaki Yanagimoto, Hiroki Yamaue, Michiaki Unno, Masanori Kon, Yoshiaki Murakami
OBJECTIVES: We retrospectively investigated the operative outcomes of patients who underwent distal pancreatectomy (DP) for invasive pancreatic ductal adenocarcinoma (PDAC) located at the body and tail. METHODS: Data from 395 patients with PDAC who underwent DP with margin-negative resection (R0 or R1) were collected from seven high-volume centers in Japan from 2001 to 2012. Among them, 72 patients underwent DP with en-bloc celiac axis resection (DP-CAR). The remaining 323 patients underwent conventional DP with splenectomy (DP-S)...
November 14, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29152270/complete-remission-of-chemo-refractory-multiple-metastatic-upper-tract-urothelial-carcinoma-by-autologous-formalin-fixed-tumor-vaccine
#16
Tatsu Miyoshi, Takeshi Kashiwabara, Atsuko Asahi, Tatsuji Kataoka, Takashi Maruyama, Rika Okada, Yoji Uemae, Tadao Ohno
A patient with chemo-refractory multiple-metastatic upper tract urothelial carcinoma (UTUC) treated by monotherapy with autologous formalin-fixed tumor vaccine (AFTV) resulted in complete remission of the lung and para-aortic lymph node metastases (ongoing >3 years after AFTV). The tumor was immunohistologically negative for PD-L1. AFTV will be an attractive treatment option.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29151538/iron-deficiency-anemia-due-to-the-long-term-use-of-a-proton-pump-inhibitor
#17
Ryosuke Imai, Takakazu Higuchi, Masaya Morimoto, Ryosuke Koyamada, Sadamu Okada
A 52-year-old man who had been taking omeprazole, a proton pump inhibitor (PPI), for 25 years developed iron deficiency anemia. An evaluation of the entire gastrointestinal tract did not reveal any possible causes of gastrointestinal blood loss. The cause of the iron deficiency was considered to be a reduction in gastrointestinal iron absorption in association with the reduced secretion of gastric acid due to PPI use. This case demonstrates that long-term PPI use for as long as 25 years may cause iron deficiency anemia and should be considered in the differential diagnosis of iron deficiency anemia in long-term PPI users...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29151511/an-intrapancreatic-accessory-spleen-that-was-difficult-to-diagnose-due-to-temporal-changes-after-splenectomy
#18
Daisuke Uchida, Koichiro Tsutsumi, Hironari Kato, Hiroyuki Okada
Accessory spleen (AS) is common anomaly, and 20% of AS cases occur in the pancreatic tail(1). An intrapancreatic AS can be difficult to distinguish from pancreatic neoplasms. In most cases, an AS is described as a hypervascular and solitary tumor, but an AS sometimes takes other forms. We herein report a rare case of an intrapancreatic AS with temporal changes in its appearance after splenectomy, which mimicked aspects of pancreatic cancer. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and Tc-99m sulfur colloid scintigraphy were useful for the diagnosis...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29151456/characterization-of-specimens-obtained-by-different-sampling-methods-for-evaluation-of-periodontal-bacteria
#19
Ayako Okada, Kaoru Sogabe, Hiroaki Takeuchi, Masaaki Okamoto, Yoshiaki Nomura, Nobuhiro Hanada
Quantitative analysis of periodontal bacteria is considered useful for clinical diagnosis, evaluation and assessment of the risk of periodontal disease. The purpose of this study was to compare the effectiveness of sampling of saliva, supragingival and subgingival plaque for evaluation of periodontal bacteria. From each of 12 subjects, i) subgingival plaque was collected from the deepest pocket using a sterile paper point, ii) stimulated whole saliva was collected after chewing gum, and iii) supragingival plaque was collected using a tooth brush...
November 17, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29150735/glycomics-of-human-embryonic-stem-cells-and-human-induced-pluripotent-stem-cells
#20
REVIEW
Jun-Ichi Furukawa, Kazue Okada, Yasuro Shinohara
Most cells are coated by a dense glycocalyx composed of glycoconjugates such as glycosphingolipids, glycoproteins, and proteoglycans. The overall glycomic profile is believed to be crucial for the diverse roles of glycans, which are mediated by specific interactions that regulate cell-cell adhesion, the immune response, microbial pathogenesis, and other cellular events. Many cell surface markers were discovered and identified as glycoconjugates such as stage-specific embryonic antigen, Tra-1-60/81 and various other cell surface molecules (e...
November 18, 2017: Glycoconjugate Journal
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