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JOURNAL ARTICLE
Sin Yi Lee, Hirotaka Shoji, Aki Shimozawa, Hirofumi Aoyagi, Yoshiaki Sato, Kazuya Tsumagari, Mika Terumitsu, Haruhiko Motegi, Kensuke Okada, Koji Sekiguchi, Junro Kuromitsu, Jin Nakahara, Tsuyoshi Miyakawa, Daisuke Ito
BACKGROUND AND OBJECTIVES: Anti-IgLON5 disease is an autoimmune neurodegenerative disorder characterized by various phenotypes, notably sleep and movement disorders and tau pathology. Although the disease is known to be associated with the neuronal cell adhesion protein IgLON5, the physiologic function of IgLON5 remains elusive. There are conflicting views on whether autoantibodies cause loss of function, activation of IgLON5, or inflammation-associated neuronal damage, ultimately leading to the disease...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
#2
JOURNAL ARTICLE
Yuta Ito, Amira Marouf, Yasunori Kogure, Junji Koya, Raphaël Liévin, Julie Bruneau, Mariko Tabata, Yuki Saito, Sumito Shingaki, Mitsuhiro Yuasa, Kentaro Yamaguchi, Koichi Murakami, Robert Weil, Manon Vavasseur, Guillaume P Andrieu, Mehdi Latiri, Layla Veleanu, Michaël Dussiot, Isabelle André, Akshay Joshi, Chantal Lagresle-Peyrou, Aude Magerus, Sammara Chaubard, David Lavergne, Emmanuel Bachy, Erika Brunet, Virginie Fataccioli, Chantal Brouzes, Camille Laurent, Laurence De Leval, Alexandra Traverse-Glehen, Céline Bossard, Marie-Cécile Parrens, Véronique Meignin, Laure Philippe, Julien Rossignol, Felipe Suarez, Jean-Marie Michot, Olivier Tournilhac, Gandhi Damaj, François Lemonnier, Christine Bôle-Feysot, Patrick Nitschké, Bruno Tesson, Cécile Laurent, Thierry Molina, Vahid Asnafi, Yosaku Watatani, Kenichi Chiba, Ai Okada, Yuichi Shiraishi, Sachiko Tsukita, Koji Izutsu, Hiroaki Miyoshi, Koichi Ohshima, Seiji Sakata, Akito Dobashi, Kengo Takeuchi, Masashi Sanada, Philippe Gaulard, Arnaud Jaccard, Seishi Ogawa, Olivier Hermine, Keisuke Kataoka, Lucile Couronné
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1...
April 24, 2024: Cancer Research
#3
JOURNAL ARTICLE
Tatsuya Sudo, Masahiko Sagawa, Sota Adachi, Yusuke Kato, Yuki Nakanishi, Tatsuya Nakamura, Shohei Yamashita, Hidehiro Kamiya, Yohei Okada
Since inorganic nanoparticles have unique properties that differ from bulk materials, their material applications have attracted attention in various fields. In order to utilize inorganic nanoparticles for functional materials, they must be dispersed without agglomeration. Therefore, the surfaces of inorganic nanoparticles are typically modified with organic ligands to improve their dispersibility. Nevertheless, the relationship between the tail group structure in organic ligands and the dispersibility of inorganic nanoparticles in organic solvents remains poorly understood...
April 24, 2024: Chemistry: a European Journal
#4
JOURNAL ARTICLE
Marino Yamamoto, Masaya Tamura, Ryohei Miyazaki, Hironobu Okada, Noriko Wada, Makoto Toi, Ichiro Murakami
BACKGROUND: The aim of this study was to assess the ability of radiologic factors such as mean computed tomography (mCT) value, consolidation/tumor ratio (C/T ratio), solid tumor size, and the maximum standardized uptake (SUVmax) value by F-18 fluorodeoxyglucose positron emission tomography to predict the presence of spread through air spaces (STAS) of lung adenocarcinoma. METHODS: A retrospective study was conducted on 118 patients those diagnosed with clinically without lymph node metastasis and having a pathological diagnosis of adenocarcinoma after undergoing surgery...
April 23, 2024: Journal of Cardiothoracic Surgery
#5
JOURNAL ARTICLE
Tatsuaki Sumiyoshi, Kenichiro Uemura, Ryuta Shintakuya, Kenjiro Okada, Kenta Baba, Takumi Harada, Masahiro Serikawa, Yasutaka Ishii, Shinya Nakamura, Koji Arihiro, Yoshiaki Murakami, Shinya Takahashi
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) patients with normal carbohydrate antigen (CA) 19-9 levels can have early-stage cancer or advanced cancer without elevation of CA19-9 level; estimating their malignant potential is difficult. This study investigated the clinical utility of the combined use of preoperative CA 19-9 and Duke pancreatic monoclonal antigen type 2 (DUPAN-2) levels in patients with PDAC. METHODS: Patients who underwent curative-intent surgery for PDAC between November 2005 and December 2021 were investigated...
April 23, 2024: Annals of Surgical Oncology
#6
JOURNAL ARTICLE
Yosuke Ishii, Saeko Okamoto, Riko Okinaka, Takato Hashizume, Chen Xu, Kexin Zhu, Yuko Nakashima, Kaoru Okada, Kazuya Takagi, Nobuo Adachi, Makoto Takahashi
PURPOSE: Excessive mechanical stress accumulates and causes knee injury. Meniscal extrusion is a key factor in detecting the reaction to cumulative mechanical stress. The accumulation of stress strongly depends on environmental conditions such as flat ground or uphill/downhill, and accumulates in knee compartments; only a few studies have reported the effects of different environments on lateral and medial meniscus extrusion. This study aimed to investigate the effects of cumulative uphill/downhill stress on the meniscal extrusion in each compartment...
2024: Frontiers in sports and active living
#7
JOURNAL ARTICLE
Alicja Pełczyńska, Wiesław Krzemiński, Vladimir Blagoderov, Lars Vilhelmsen, Agnieszka Soszyńska
Until now, the genus Robsonomyia was represented by two extant species: R. reducta Matile & Vockeroth, 1980 from North America and R. sciaraeformis (Okada, 1939) from Asia. This paper presents the first fossil members of the genus Robsonomyia, which is also the first record from Europe. Two new fossil species from Baltic amber are described: R. baltica Pełczyńska, Krzemiński & Blagoderov, sp. nov. and R. henningseni Pełczyńska, Krzemiński & Blagoderov, sp. nov...
April 22, 2024: Scientific Reports
#8
JOURNAL ARTICLE
Akira Kawauchi, Yohei Okada, Makoto Aoki, Tomoko Ogasawara, Takashi Tagami, Nobuya Kitamura, Mitsunobu Nakamura
AIM: Selecting the appropriate candidates for extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) is challenging. Previously, the Extracorporeal Life Support Organization (ELSO) guidelines suggested the example of inclusion criteria. However, it is unclear whether patients who meet the inclusion criteria of the ELSO guidelines have more favorable outcomes. We aimed to evaluate the relationship between the outcomes and select inclusion criteria of the ELSO guidelines...
April 20, 2024: Resuscitation
#9
Takuya Ogawa, Jingyi Xue, Long Guo, Maristela Sayuri Inoue-Arai, Siulan Vendramini-Pittoli, Roseli Maria Zechi-Ceide, Rosana Maria Candido-Souza, Cristiano Tonello, Michele Madeira Brandão, Terumi Okada Ozawa, Adriano Porto Peixoto, Daniela Maria Cury Ferreira Ruiz, Tomoki Nakashima, Shiro Ikegawa, Keiji Moriyama, Nancy Mizue Kokitsu-Nakata
Craniofacial microsomia (CFM), also known as the oculo-auriculo-vertebral spectrum, is a congenital disorder characterized by hypoplasia of the mandible and external ear due to tissue malformations originating from the first and second branchial arches. However, distinguishing it from other syndromes of branchial arch abnormalities is difficult, and causal variants remain unidentified in many cases. In this report, we performed an exome sequencing analysis of a Brazilian family with CFM. The proband was a 12-month-old boy with clinical findings consistent with the diagnostic criteria for CFM, including unilateral mandibular hypoplasia, microtia, and external auditory canal abnormalities...
April 22, 2024: American Journal of Medical Genetics. Part A
#10
Ayumi Omuro, Tetsuya Matsuyama, Seigo Okada, Takayuki Okamura
UNLABELLED: A 34-year-old man with a history of Kawasaki disease had been experiencing chest pain at rest since middle school. Multidetector-row computed tomography showed no aneurysm formation; however, the right coronary artery had an anomalous origin with moderate stenosis. Invasive coronary angiography revealed moderate right coronary artery stenosis with a fractional flow reserve of 0.97. Finally, with a positive acetylcholine provocation test and elevated index of microvascular resistance, the patient was diagnosed with microvascular and epicardial vasospastic angina in the endotypes of ischemia with nonobstructive coronary arteries...
April 2024: Journal of Cardiology Cases
#11
Yuto Tamaoki, Ryo Kamidani, Hideshi Okada, Takahito Miyake, Kodai Suzuki, Takahiro Yoshida, Keisuke Kumada, Shozo Yoshida, Shinji Ogura
Subclavian artery injuries during internal jugular vein puncture when attempting central venous catheter insertion are rare. A 60-year-old man undergoing treatment for neuromyelitis optica with paralysis and sensory loss developed a complication during catheter placement into his right internal jugular vein for plasmapheresis. His previous physician felt resistance and discontinued the procedure. The patient later developed mild dyspnea and dysphagia. Computed tomography scans indicated thrombus formation and tracheal deviation...
July 2024: Radiology Case Reports
#12
JOURNAL ARTICLE
Tsuyoshi Miki, Takeshi Haneda, Nobuhiko Okada, Masahiro Ito
Colonization resistance, conferred by the host's microbiota through both direct and indirect protective actions, serves to protect the host from enteric infections. Here, we identified the specific members of the gut microbiota that impact gastrointestinal colonization by Citrobacter rodentium, a murine pathogen causing colonic crypt hyperplasia. The gut colonization levels of C. rodentium in C57BL/6 mice varied among breeding facilities, probably due to differences in microbiota composition. A comprehensive analysis of the microbiota revealed that specific members of the microbiota may influence gut colonization by C...
April 21, 2024: Microbiology and Immunology
#13
JOURNAL ARTICLE
Reiko Okada, Yasutaka Murakami, Ayami Machiyama, Jyunki Jinno, Makoto Hideshima, Hideaki Kanki
A 46-year-old man with neck pain and impaired physical mobility called for emergency medical services. The patient was able to communicate with the emergency medical team upon their arrival. However, he went into cardiopulmonary arrest 5 minutes later. Cardiopulmonary resuscitation was immediately performed, and the patient was admitted to our hospital with a Glasgow Coma Scale score of E1V1M1. His respiratory rate was 5 breaths/minute and his partial pressure of carbon dioxide in arterial blood (PaCO2 ) was 127 mmHg, necessitating intubation and ventilation...
April 20, 2024: Rinshō Shinkeigaku, Clinical Neurology
#14
JOURNAL ARTICLE
Miki Watanabe, Miho Uematsu, Kosuke Fujimoto, Takeshi Hara, Mako Yamamoto, Daichi Miyaoka, Chieko Yokota, Yukari Kamei, Akira Sugimoto, Natsuko Kawasaki, Takato Yabuno, Noriaki Sato, Shintaro Sato, Kiyoshi Yamaguchi, Yoichi Furukawa, Daisuke Tsuruta, Fumihiro Okada, Seiya Imoto, Satoshi Uematsu
No abstract text is available yet for this article.
April 18, 2024: Journal of Investigative Dermatology
#15
JOURNAL ARTICLE
Yu Hashimoto, Yoshio Tokumoto, Takao Watanabe, Yusuke Ogi, Hiroki Sugishita, Satoshi Akita, Kazuki Niida, Mirai Hayashi, Masaya Okada, Kana Shiraishi, Kazuhiro Tange, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Taro Oshikiri, Yoichi Hiasa
Double-stranded RNA-activated protein kinase R (PKR) is highly expressed in colorectal cancer (CRC). However, the role of PKR in CRC remains unclear. The aim of this study was to clarify whether C16 (a PKR inhibitor) exhibits antitumor effects and to identify its target pathway in CRC. We evaluated the effects of C16 on CRC cell lines using the MTS assay. Enrichment analysis was performed to identify the target pathway of C16. The cell cycle was analyzed using flow cytometry. Finally, we used immunohistochemistry to examine human CRC specimens...
April 19, 2024: Scientific Reports
#16
Hui Shi, Yuanjian Fang, Lei Huang, Ling Gao, Cameron Lenahan, Takeshi Okada, Zachary D Travis, Shucai Xie, Hong Tang, Qin Lu, Rui Liu, Jiping Tang, Yuan Cheng, John H Zhang
No abstract text is available yet for this article.
April 18, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
#17
JOURNAL ARTICLE
Shinnosuke Kikuchi, Yugo Minamimoto, Kensuke Matsushita, Tomoki Cho, Kengo Terasaka, Yohei Hanajima, Hidefumi Nakahashi, Masaomi Gohbara, Yuichiro Kimura, Shota Yasuda, Kozo Okada, Yasushi Matsuzawa, Noriaki Iwahashi, Masami Kosuge, Toshiaki Ebina, Olivier Morel, Patrick Ohlmann, Keiji Uchida, Kiyoshi Hibi
BACKGROUND: A delayed and recurrent complete atrioventricular block (CAVB) is a life-threatening complication of transcatheter aortic valve replacement (TAVR). Post-TAVR evaluation may be important in predicting delayed and recurrent CAVB requiring permanent pacemaker implantation (PPI). The impact of new-onset right bundle-branch block (RBBB) after TAVR on PPI remains unknown. METHODS AND RESULTS: In total, 407 patients with aortic stenosis who underwent TAVR were included in this analysis...
April 19, 2024: Journal of the American Heart Association
#18
JOURNAL ARTICLE
Kenji Kandori, Asami Okada, Satoshi Nakajima, Tasuku Matsuyama, Tetsuhisa Kitamura, Hiromichi Narumiya, Ryoji Iizuka, Masahito Hitosugi, Yohei Okada
AIM: We aimed to investigate the association between estimated glomerular filtration rate and prognosis in out-of-hospital cardiac arrest patients and explore the heterogeneity of the association. METHODS: Patients experiencing out-of-hospital cardiac arrest due to medical causes and registered in the JAAM-OHCA Registry between June 2014 and December 2019 were stratified into shockable rhythm, pulseless electrical activity, and asystole groups according to the cardiac rhythm at the scene...
2024: Acute Medicine & Surgery
#19
Kimitaka Shibue, Nozomi Kubo, Hiromi Oda, Etsuko Tanabe, Tsutomu Okada, Cheng-Long Huang, Toshihiro Higuchi, Akihiro Hamasaki, Nobuya Inagaki
In the realm of obstetric care, discerning the subtle signs of primary hyperparathyroidism (PHPT) amidst common pregnancy symptoms remains a formidable challenge. Our exploration into a case of gestational hypercalcemia peels back the layers of this complexity, revealing the clinical conundrum posed by overlapping gastrointestinal manifestations. The journey from diagnosis through surgical intervention to the resolution of symptoms underscores the importance of vigilance for PHPT in pregnant patients. This case further prompts consideration of gamma-aminobutyric acid (GABA) as a potential piece in the puzzle of persistent symptoms post-calcium normalization, inviting a broader dialogue on the intricacies of parathyroid pathology in pregnancy...
March 2024: Curēus
#20
JOURNAL ARTICLE
Francesco Massari, Matteo Santoni, Hideki Takeshita, Yohei Okada, Jose Carlos Tapia, Umberto Basso, Marco Maruzzo, Sarah Scagliarini, Thomas Büttner, Giuseppe Fornarini, Zin W Myint, Luca Galli, Vinicius Carrera Souza, Renate Pichler, Ugo De Giorgi, Nathalia Gandur, Elaine T Lam, Danielle Gilbert, Lazar Popovic, Enrique Grande, Giulia Mammone, Rossana Berardi, Simon J Crabb, Robert Kemp, Javier Molina-Cerrillo, Marcelo Freitas, Murilo Luz, Roberto Iacovelli, Fabio Calabrò, Deniz Tural, Francesco Atzori, Zsófia Küronya, Rita Chiari, Saul Campos, Orazio Caffo, André P Fay, Jakub Kucharz, Paolo Andrea Zucali, José Augusto Rinck, Annalisa Zeppellini, Diogo Assed Bastos, Gaetano Aurilio, Augusto Mota, Karine Trindade, Cinzia Ortega, Juan Pablo Sade, Mimma Rizzo, Ondřej Fiala, Nuno Vau, Patrizia Giannatempo, Allan Barillas, Fernando Sabino M Monteiro, Breno Dauster, Alessia Mennitto, Lucas Nogueira, Roni de Carvalho Fernandes, Emmanuel Seront, Luís Garcia Aceituno, Francesco Grillone, Hernan Javier Cutuli, Mauricio Fernandez, Maria Bassanelli, Ray Manneh Kopp, Giandomenico Roviello, Halima Abahssain, Giuseppe Procopio, Michele Milella, Jindrich Kopecky, Angelo Martignetti, Carlo Messina, Manuel Caitano, Eva Inman, Ravindran Kanesvaran, Daniel Herchhorn, Daniele Santini, Aristotelis Bamias, Renato Bisonni, Alessandra Mosca, Franco Morelli, Fernando Maluf, Andrey Soares, Fernando Nunes, Alvaro Pinto, Anca Zgura, Lorena Incorvaia, Jawaher Ansari, Ignacio Ortego Zabalza, Johannes Landmesser, Alessandro Rizzo, Veronica Mollica, Andrea Marchetti, Matteo Rosellini, Giulia Sorgentoni, Nicola Battelli, Sebastiano Buti, Camillo Porta, Joaquim Bellmunt
BACKGROUND: Immune checkpoint inhibitors have changed previous treatment paradigm of advanced urothelial carcinoma (UC). The ARON-2 study (NCT05290038) aimed to assess the real-world effectiveness of pembrolizumab in patients recurred or progressed after platinum-based chemotherapy. PATIENTS AND METHODS: Medical records of patients with documented metastatic UC treated by pembrolizumab as second-line therapy were retrospectively collected from 88 institutions in 23 countries...
April 18, 2024: Cancer Immunology, Immunotherapy: CII
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