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https://www.readbyqxmd.com/read/29649303/a-new-diatom-species-p-hallegraeffii-sp-nov-belonging-to-the-toxic-genus-pseudo-nitzschia-bacillariophyceae-from-the-east-australian-current
#1
Penelope A Ajani, Arjun Verma, Malwenn Lassudrie, Martina A Doblin, Shauna A Murray
A new species belonging to the toxin producing diatom genus Pseudo-nitzschia, P. hallegraeffii sp. nov., is delineated and described from the East Australian Current (EAC). Clonal cultures were established by single cell isolation from phytoplankton net hauls collected as part of a research expedition in the EAC region in 2016 on the RV Investigator. Cultures were assessed for their morphological and genetic characteristics, their sexual compatibility with other Pseudo-nitzschia species, and their ability to produce domoic acid...
2018: PloS One
https://www.readbyqxmd.com/read/29625197/a-single-subconvulsant-dose-of-domoic-acid-at-mid-gestation-does-not-cause-temporal-lobe-epilepsy-in-mice
#2
Fanny Demars, Kristen Clark, Megan S Wyeth, Emily Abrams, Paul S Buckmaster
Harmful blooms of domoic acid (DA)-producing algae are a problem in oceans worldwide. DA is a potent glutamate receptor agonist that can cause status epilepticus and in survivors, temporal lobe epilepsy. In mice, one-time low-dose in utero exposure to DA was reported to cause hippocampal damage and epileptiform activity, leading to the hypothesis that unrecognized exposure to DA from contaminated seafood in pregnant women can damage the fetal hippocampus and initiate temporal lobe epileptogenesis. However, development of epilepsy (i...
April 3, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29602502/blurred-lines-multiple-freshwater-and-marine-algal-toxins-at-the-land-sea-interface-of-san-francisco-bay-california
#3
Melissa B Peacock, Corinne M Gibble, David B Senn, James E Cloern, Raphael M Kudela
San Francisco Bay (SFB) is a eutrophic estuary that harbors both freshwater and marine toxigenic organisms that are responsible for harmful algal blooms. While there are few commercial fishery harvests within SFB, recreational and subsistence harvesting for shellfish is common. Coastal shellfish are monitored for domoic acid and paralytic shellfish toxins (PSTs), but within SFB there is no routine monitoring for either toxin. Dinophysis shellfish toxins (DSTs) and freshwater microcystins are also present within SFB, but not routinely monitored...
March 2018: Harmful Algae
https://www.readbyqxmd.com/read/29602500/differential-toxin-response-of-pseudo-nitzschia-multiseries-as-a-function-of-nitrogen-speciation-in-batch-and-continuous-cultures-and-during-a-natural-assemblage-experiment
#4
Regina L Radan, William P Cochlan
The toxigenic diatom Pseudo-nitzschia multiseries Hasle, isolated from the U.S. Pacific Northwest, was examined in unialgal laboratory cultures and in natural assemblages during shipboard experiments, to examine cellular growth and domoic acid (DA) production as a function of nitrogen (N) substrate and availability expected during bloom development and decline. Laboratory experiments utilizing batch cultures conducted at saturating (120 μmol photons m-2  s-1 ) photosynthetic photon flux density (PPFD), demonstrated that P...
March 2018: Harmful Algae
https://www.readbyqxmd.com/read/29547358/investigation-of-a-largescale-common-murre-uria-aalge-mortality-event-in-california-in-2015
#5
Corinne Gibble, Rebecca Duerr, Barbara Bodenstein, Kirsten Lindquist, Jackie Lindsey, Jessie Beck, Laird Henkel, Jan Roletto, Jim Harvey, Raphael Kudela
From August through December 2015, beachcast bird survey programs reported increased deposition of common murres ( Uria aalge) on central and northern California beaches, but not on southern California beaches. Coastal wildlife rehabilitation centers received more than 1,000 live, stranded, and debilitated murres from Sonoma County to San Luis Obispo County during August-October. Approximately two-thirds of admitted birds were after-hatch-year birds in emaciated body condition and in various stages of molt, with extremely worn plumage...
March 16, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29495583/repeated-dietary-exposure-to-low-levels-of-domoic-acid-and-problems-with-everyday-memory-research-to-public-health-outreach
#6
Lynn M Grattan, Carol J Boushey, Yuanyuan Liang, Kathi A Lefebvre, Laura J Castellon, Kelsey A Roberts, Alexandra C Toben, J G Morris
Domoic Acid (DA) is a marine-based neurotoxin. Dietary exposure to high levels of DA via shellfish consumption has been associated with Amnesic Shellfish Poisoning, with milder memory decrements found in Native Americans (NAs) with repetitive, lower level exposures. Despite its importance for protective action, the clinical relevance of these milder memory problems remains unknown. The purpose of this study was to determine whether repeated, lower-level exposures to DA impact everyday memory (EM), i.e., the frequency of memory failures in everyday life...
February 28, 2018: Toxins
https://www.readbyqxmd.com/read/29433033/applying-molecular-modelling-and-experimental-studies-to-develop-molecularly-imprinted-polymer-for-domoic-acid-enrichment-from-both-seawater-and-shellfish
#7
Junjie Ao, Jiaping Gu, Tao Yuan, Dan Li, Yuning Ma, Zhemin Shen
A highly selective sample cleanup method using molecularly imprinted polymers (MIP) was developed for the enrichment of domoic acid (DA, an amnesic shellfish toxin) from both seawater and shellfish samples. Molecular modelling was firstly applied to screening a suitable functional monomer and optimize the polymer preparation. Theoretical results were in a good agreement with those of the experimental studies. MIP was prepared by precipitation polymerization using 1, 3, 5-pentanetricarboxylic acid and 2-(Trifluoromethyl)acrylic acid as the template molecule and functional monomer, respectively...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29368303/determination-of-domoic-acid-in-plankton-net-samples-from-golden-horn-estuary-turkey-using-hplc-with-fluorescence-detection
#8
Fuat Dursun, Selma Ünlü, Türkan Yurdun
This study focused on the fluctuations of domoic acid (DA) levels in plankton net samples collected from the Golden Horn Estuary (GHE), Turkey, between August 2011 and July 2012. DA concentrations were determined by high-performance liquid chromatography (HPLC), using a fluorenylmethoxycarbonyl (FMOC) derivatization technique. Monthly and biweekly data were evaluated with environmental variables, and their influence on DA production is discussed. DA levels in plankton net samples varied between 0.36 and 94...
January 24, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29321590/six-domoic-acid-related-compounds-from-the-red-alga-chondria-armata-and-domoic-acid-biosynthesis-by-the-diatom-pseudo-nitzschia-multiseries
#9
Yukari Maeno, Yuichi Kotaki, Ryuta Terada, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodomoic acid A (2) and B (3), N-geranyl-L-glutamic acid (4), 7'-hydroxymethyl-isodomoic acid A (5) and B (6), and N-geranyl-3(R)-hydroxy-L-glutamic acid (7), were isolated from the red alga, Chondria armata, and their structures were determined...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313078/preparation-and-application-of-a-molecularly-imprinted-monolith-for-specific-recognition-of-domoic-acid
#10
Fan Yang, Ruirui Wang, Guangshui Na, Qilun Yan, Zhongsheng Lin, Zhifeng Zhang
In this work, a molecularly imprinted monolithic column was synthesized by a facile procedure and was applied for specific recognition of domoic acid, an amnesic shellfish poison. The poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) molecularly imprinted monolith was synthesized in a stainless steel column by in situ polymerization. Pentane-1,3,5-tricarboxylic acid was used as a dummy imprinting template instead of the highly toxic and expensive target molecule. It is the first time that a molecularly imprinted monolith is introduced for separation and detection of domoic acid...
February 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29223596/presence-and-persistence-of-the-amnesic-shellfish-poisoning-toxin-domoic-acid-in-octopus-and-cuttlefish-brains
#11
Vanessa M Lopes, Rui Rosa, Pedro R Costa
Domoic acid (DA) is a neurotoxin that causes degenerative damage to brain cells and induces permanent short-term memory loss in mammals. In cephalopod mollusks, although DA is known to accumulate primarily in the digestive gland, there is no knowledge whether DA reaches their central nervous system. Here we report, for the first time, the presence of DA in brain tissue of the common octopus (Octopus vulgaris) and the European cuttlefish (Sepia officinalis), and its absence in the brains of several squid species (Loligo vulgaris, L...
February 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29169567/sandwich-hybridization-probes-for-the-detection-of-pseudo-nitzschia-bacillariophyceae-species-an-update-to-existing-probes-and-a-description-of-new-probes
#12
Holly A Bowers, Roman Marin, James M Birch, Christopher A Scholin
New sandwich hybridization assay (SHA) probes for detecting Pseudo-nitzschia species (P. arenysensis, P. fraudulenta, P. hasleana, P. pungens) are presented, along with updated cross-reactivity information on historical probes (SHA and FISH; fluorescence in situ hybridization) targeting P. australis and P. multiseries. Pseudo-nitzschia species are a cosmopolitan group of diatoms that produce varying levels of domoic acid (DA), a neurotoxin that can accumulate in finfish and shellfish and transfer throughout the food web...
December 2017: Harmful Algae
https://www.readbyqxmd.com/read/29150543/toxicokinetics-and-physiologically-based-pharmacokinetic-modeling-of-the-shellfish-toxin-domoic-acid-in-nonhuman-primates
#13
Jing Jing, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Ariel R Topletz, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen
Domoic acid (DA), a neurotoxin, is produced by marine algae and has caused toxications worldwide in animals and humans. However, the toxicokinetics of DA have not been fully evaluated, and information is missing on the disposition of DA following oral exposures at doses that are considered safe for human consumption. In this study, toxicokinetics of DA were investigated in cynomolgus monkeys following single doses of 5 µ g/kg DA intravenously, 0.075 mg/kg DA orally, and 0.15 mg/kg DA orally. After intravenous dosing, DA had a systemic clearance of 124 ± 71 (ml/h)/kg, volume of distribution at steady state of 131 ± 71 ml/kg and elimination half-life of 1...
February 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29124474/growth-chain-formation-and-toxin-production-by-southern-brazilian-pseudo-nitzschia-isolates-under-laboratory-conditions
#14
Pedro Rebelo Wadt, Luiz Laureno Mafra, Camila Prestes Dos Santos Tavares, Luciano Felício Fernandes, Luís Antonio de Oliveira Proença
Pseudo-nitzschia is a diatom genus capable of producing the neurotoxin domoic acid (DA), which has been related to mortalities of marine vertebrates, and the amnesic shellfish poisoning (ASP) in human consumers of contaminated bivalves. This study reports DA production among Pseudo-nitzschia strains isolated from shellfish farming areas in southern Brazil. Twenty-seven cultures of potentially toxigenic Pseudo-nitzschia species were established. Growth, stepped-chain formation, and DA production were evaluated in static, intermittently illuminated (12:12 photoperiod) batch cultures for 12 selected strains, and under continuous light and/or turbulence for a single Pseudo-nitzschia calliantha strain...
November 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29122243/the-influence-of-salinity-in-the-domoic-acid-effect-on-estuarine-phytoplankton-communities
#15
Elise Van Meerssche, James L Pinckney
Toxic species of the diatom genus Pseudo-nitzschia, observed worldwide from coastal waters to the open ocean, produce the neurotoxin domoic acid (DA). DA is an important environmental and economic hazard due to shellfish contamination with subsequent effects on higher trophic levels. Previous research has demonstrated that, among other environmental factors, salinity influences the abundance and toxicity of Pseudo-nitzschia. In this study, the environmental factors driving the growth of Pseudo-nitzschia and the production of dissolved DA (dDA) in North Inlet estuary were examined...
November 2017: Harmful Algae
https://www.readbyqxmd.com/read/29064395/growth-toxin-production-and-allelopathic-effects-of-pseudo-nitzschia-multiseries-under-iron-enriched-conditions
#16
Bruna Fernanda Sobrinho, Luana Mocelin de Camargo, Leonardo Sandrini-Neto, Cristian Rafael Kleemann, Eunice da Costa Machado, Luiz Laureno Mafra
In order to assess the effects of Fe-enrichment on the growth and domoic acid (DA) production of the toxigenic diatom Pseudo-nitzschia multiseries , static cultures that received the addition of different iron (Fe) concentrations were maintained for 30 days. Intra- and extracellular DA concentrations were evaluated over time, and growth and chain-formation were compared to those of non-toxic diatoms, Bacillaria sp. Growth rates of P. multiseries (μ = 0.45-0.73 d-1 ) were similar among cultures containing different Fe concentrations...
October 24, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29031804/transcriptional-response-after-exposure-to-domoic-acid-producing-pseudo-nitzschia-in-the-digestive-gland-of-the-mussel-mytilus-galloprovincialis
#17
Antonio J Pazos, Pablo Ventoso, Roi Martínez-Escauriaza, M Luz Pérez-Parallé, Juan Blanco, Juan C Triviño, José L Sánchez
Bivalve molluscs are filter feeding species that can accumulate biotoxins in their body tissues during harmful algal blooms. Amnesic Shellfish Poisoning (ASP) is caused by species of the diatom genus Pseudo-nitzschia, which produces the toxin domoic acid. The Mytilus galloprovincialis digestive gland transcriptome was de novo assembled based on the sequencing of 12 cDNA libraries, six obtained from control mussels and six from mussels naturally exposed to domoic acid-producing diatom Pseudo-nitzschia australis...
October 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29029261/from-the-cover-selective-enhancement-of-domoic-acid-toxicity-in-primary-cultures-of-cerebellar-granule-cells-by-lowering-extracellular-na-concentration
#18
Anabel Pérez-Gómez, David Cabrera-García, Davide Warm, Ann M Marini, Javier Salas Puig, Maria Teresa Fernández-Sánchez, Antonello Novelli
Domoic acid (DOM) is an excitatory amino acid analog of kainic acid (KA) that acts through glutamic acid (GLU) receptors, inducing a fast and potent neurotoxic response. Here, we present evidence for an enhancement of excitotoxicity following exposure of cultured cerebellar granule cells to DOM in the presence of lower than physiological Na+ concentrations. The concentration of DOM that reduced by 50% neuronal survival was approximately 3 µM in Na+-free conditions and 16 µM in presence of a physiological concentration of extracellular Na+...
January 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29021835/progressive-changes-in-hippocampal-cytoarchitecture-in-a-neurodevelopmental-rat-model-of-epilepsy-implications-for-understanding-presymptomatic-epileptogenesis-predictive-diagnosis-and-targeted-treatments
#19
Paul B Bernard, Leslie A Ramsay, Debra S MacDonald, R Andrew Tasker
Epilepsies affect about 4% of the population and are frequently characterized by a prolonged "silent" period before the onset of spontaneous seizures. Most current animal models of epilepsy either involve acute seizure induction or kindling protocols that induce repetitive seizures. We have developed a rat model of epilepsy that is characterized by a slowly progressing series of behavioral abnormalities prior to the onset of behavioral seizures. In the current study, we further describe an accompanying progression of cytoarchitectural changes in the hippocampal formation...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/29021833/what-california-sea-lions-exposed-to-domoic-acid-might-teach-us-about-autism-lessons-for-predictive-and-preventive-medicine
#20
REVIEW
Garet Paul Lahvis
Autism spectrum disorder (ASD) shares many biological and behavioral similarities with the deleterious effects of domoic acid (DA) exposure. DA is produced by marine algae and most commonly by species of Pseudo-nitzschia . Humans and marine mammals can be exposed to DA when they consume whole fish or shellfish. The mammalian fetus is highly sensitive to the deleterious effects of DA exposure. Both ASD and exposures to toxic levels of DA feature repetitive behaviors, challenges with social interaction, and seizures...
September 2017: EPMA Journal
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