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https://www.readbyqxmd.com/read/29470250/clinically-oriented-device-programming-in-bradycardia-patients-part-1-sinus-node-disease-proposals-from-aiac-italian-association-of-arrhythmology-and-cardiac-pacing
#1
Matteo Ziacchi, Pietro Palmisano, Mauro Biffi, Renato P Ricci, Maurizio Landolina, Massimo Zoni-Berisso, Eraldo Occhetta, Giampiero Maglia, Gianluca Botto, Luigi Padeletti, Giuseppe Boriani
: Modern pacemakers have an increasing number of programable parameters and specific algorithms designed to optimize pacing therapy in relation to the individual characteristics of patients. When choosing the most appropriate pacemaker type and programing, the following variables must be taken into account: the type of bradyarrhythmia at the time of pacemaker implantation; the cardiac chamber requiring pacing, and the percentage of pacing actually needed to correct the rhythm disorder; the possible association of multiple rhythm disturbances and conduction diseases; the evolution of conduction disorders during follow-up...
February 20, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29470248/role-of-cardiovascular-imaging-in-cardiac-resynchronization-therapy-a-literature-review
#2
Biagio Sassone, Gaetano Nucifora, Donato Mele, Cinzia Valzania, Giovanni Bisignani, Giuseppe Boriani
: Cardiac resynchronization therapy (CRT) is an established treatment in patients with symptomatic drug-refractory heart failure and broad QRS complex on the surface ECG. Despite the presence of either mechanical dyssynchrony or viable myocardium at the site where delivering left ventricular pacing being necessary conditions for a successful CRT, their direct assessment by techniques of cardiovascular imaging, though feasible, is not recommended in clinical practice by the current guidelines. Indeed, even though there is growing body of data providing evidence of the additional value of an image-based approach as compared with routine approach in improving response to CRT, these results should be confirmed in prospective and large multicentre trials before their impact on CRT guidelines is considered...
February 20, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29468473/clinical-aspects-of-myocardial-fibrosis-in-adults-with-ebstein-s-anomaly
#3
Aleksandra Ciepłucha, Olga Trojnarska, Anna Kociemba, Magdalena Łanocha, Mikolaj Barczynski, Szymon Rozmiarek, Lucyna Kramer, Malgorzata Pyda
Heart failure and arrhythmia are common complications in adults with Ebstein's anomaly. They may result not only from hemodynamic alterations, but also from myocardial fibrosis. Late gadolinium enhancement (LGE) by CMR enables the evaluation of myocardial fibrosis. The aim of the study was to asses the presence of LGE and its relation to clinical outcome. We studied a group of 37 unoperated adults aged 43.0 ± 14.4 years with Ebstein's anomaly from the congenital heart disease outpatient clinic. Study protocol included: cardiopulmonary test, assessment of supraventricular arrhythmia (SVA), and CMR with evaluation of cardiac chambers' morphology and function, and presence of LGE...
February 21, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29467337/nitric-oxide-sensitive-guanylyl-cyclase-stimulation-improves-experimental-heart-failure-with-preserved-ejection-fraction
#4
Nicola Wilck, Lajos Markó, András Balogh, Kristin Kräker, Florian Herse, Hendrik Bartolomaeus, István A Szijártó, Maik Gollasch, Nadine Reichhart, Olaf Strauss, Arnd Heuser, Damian Brockschnieder, Axel Kretschmer, Ralf Lesche, Florian Sohler, Johannes-Peter Stasch, Peter Sandner, Friedrich C Luft, Dominik N Müller, Ralf Dechend, Nadine Haase
Heart failure with preserved ejection fraction (HFpEF) can arise from cardiac and vascular remodeling processes following long-lasting hypertension. Efficacy of common HF therapeutics is unsatisfactory in HFpEF. Evidence suggests that stimulators of the nitric oxide-sensitive soluble guanylyl cyclase (NOsGC) could be of use here. We aimed to characterize the complex cardiovascular effects of NOsGC stimulation using NO-independent stimulator BAY 41-8543 in a double-transgenic rat (dTGR) model of HFpEF. We show a drastically improved survival rate of treated dTGR...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29467289/protonation-state-of-inhibitors-determines-interaction-sites-within-voltage-gated-sodium-channels
#5
Amanda Buyan, Delin Sun, Ben Corry
Voltage-gated sodium channels are essential for carrying electrical signals throughout the body, and mutations in these proteins are responsible for a variety of disorders, including epilepsy and pain syndromes. As such, they are the target of a number of drugs used for reducing pain or combatting arrhythmias and seizures. However, these drugs affect all sodium channel subtypes found in the body. Designing compounds to target select sodium channel subtypes will provide a new therapeutic pathway and would maximize treatment efficacy while minimizing side effects...
February 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29466924/ventriculoatrial-synchrony-induced-heart-failure
#6
Stefan Andric, Dragica Tesic, Dalibor Somer, Ilija Srdanovic, Tatjana Miljkovic, Djordje G Jakovljevic, Lazar Velicki
OBJECTIVE AND IMPORTANCE: Endless loop tachycardia or pacemaker-mediated tachycardia, and atrioventricular desynchronization arrhythmia or repetitive non-reentrant ventriculoatrial synchrony (RNRVAS) are two forms of reverse impulse conduction - ventriculoatrial (VA) synchrony. Although VA synchrony can theoretically cause aggravation of heart failure, clinical cases describing severe consequential heart failure are lacking. CLINICAL PRESENTATION AND INTERVENTION: We describe a case of a 60-year-old patient who underwent primary percutaneous coronary intervention and mitral valve surgery...
February 21, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29466214/-sudden-cardiac-death-in-patients-with-ischemic-heart-disease-from-mechanisms-to-clinical-practice
#7
E Z Golukhova, O I Gromova, N I Bulaeva, L A Bokeria
Ischemic heart disease (IHD) and acute coronary syndrome are the main cause of sudden cardiac death (SCD). Incidence of SCD in patients after myocardial infarction (MI) is 4-6-fold higher than in general population. The review focuses on electrophysiological changes during acute myocardial ischemia and mechanisms of myocardial electromechanical remodeling in remote period after MI. Current data on arrhythmia substrates and triggers are presented. Nowadays, the main guide for implantable cardioverter-defibrillator (ICD) use for primary prevention of SCD is reduced left ventricular ejection fraction...
December 2017: Kardiologiia
https://www.readbyqxmd.com/read/29466203/-use-of-highly-concentrated-polyunsaturated-fatty-acids-for-prevention-of-complications-after-myocardial-infarction-cost-utility-analysis
#8
S L Plavinskii, A N Barinova
Use of highly concentrated ethyl esters of polyunsaturated fatty acids after myocardial infarction (MI) and in patients with heart failure was associated with lower mortality. The goal of this analysis was to perform cost-utility analysis of the use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI (with help of a Markov model) and to find whether its use in some group of patients led to decrease in budget costs. As a result, we have shown that use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI leads to increase in quality-adjusted life expectancy on 0...
February 2018: Kardiologiia
https://www.readbyqxmd.com/read/29465292/an-unusual-case-of-sudden-cardiac-death-during-sexual-intercourse
#9
Cristina Mondello, Elvira Ventura Spagnolo, Luigi Cardia, Orazio Ventura Spagnolo, Patrizia Gualniera, Antonina Argo
The most common cause of sudden death during sexual intercourse in adults is heart disease, and it is usually the male, whereas the death of the woman is unusual. Generally, in these cases, death occurs as a result of cardiovascular disease. The authors report an unusual case of the sudden death of a young woman during sexual intercourse. The post-mortem investigations (autopsy, cardiac nuclear magnetic resonance and cardiac histology) demonstrated a previously undiagnosed arrhythmogenic right ventricular cardiomyopathy...
January 1, 2018: Medico-legal Journal
https://www.readbyqxmd.com/read/29464418/annual-costs-attributed-to-atrial-fibrillation-management-cross-sectional-study-of-primary-healthcare-electronic-records
#10
Marc Casajuana, Maria Giner-Soriano, Albert Roso-Llorach, Cristina Vedia, Concepció Violan, Rosa Morros
Atrial fibrillation (AF) is the most common chronic arrhythmia, with increasing healthcare and economic burden and a prevalence which increases with progressive ageing. This study aims to describe overall annual costs per patient for management of non-valvular AF in a primary healthcare (PHC) setting and compare these costs between the groups of patients treated with vitamin K antagonists, antiplatelets or non-treated through a population-based study conducted with electronic health records. We analysed annual costs per person of 19,787 patients in 2012; PHC visits, hospital admissions, AF-related events requiring hospital admission, referrals to secondary specialists, sick leave, diagnostic tests and laboratory tests at PHC level, including INR determinations performed in PHC, and drug therapy...
February 20, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29464142/decreased-renal-function-is-associated-with-elevated-cha2ds2vasc-and-r2chads2-scores-in-non-valvular-atrial-fibrillation-patients-presenting-with-stroke
#11
Mohinder Vindhyal, Shravani R Vindhyal, Travis Haneke, Paul M Ndunda, Freidy Eid, K James Kallail
Introduction Atrial fibrillation (AF), the most common cardiac arrhythmia, affects approximately 2.3 million patients in the United States, costing around $26 billion. Atrial fibrillation is associated with a two- to seven-fold increased risk of stroke, one of the most serious complications. Chronic kidney disease affects approximately 13% of the US population and has been associated with higher rates of AF than the general population. In patients with chronic kidney disease (CKD), the risk of stroke increases as the glomerular filtration rate (GFR) decreases, especially in CKD stages three and four...
December 11, 2017: Curēus
https://www.readbyqxmd.com/read/29464094/a-meta-analysis-on-omega-3-supplements-in-preventing-recurrence-of-atrial-fibrillation
#12
Ying Jiang, Hui Ching Tan, Wilson Wai San Tam, Toon Wei Lim, Wenru Wang
Previous studies had suggested that Omega-3 fatty acids have pleiotropic effects and favourable safety profile, which may potentially increase the efficacy of antiarrhythmic drugs in suppressing atrial arrhythmias through combination therapy. This meta-analysis aimed to determine the effectiveness of using Omega-3 polyunsaturated fatty acids as a sole anti-arrhythmic agent or as an adjunct to existing pharmacological therapies in preventing atrial fibrillation recurrence. Randomized controlled trials published in English, from inception to December 2016, were considered...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463526/elevated-plasma-moxifloxacin-concentrations-and-slco1b1-g-11187g-a-polymorphism-in-adults-with-pulmonary-tuberculosis
#13
Marc Weiner, Jon Gelfond, Teresa L Johnson-Pais, Melissa Engle, Charles A Peloquin, John L Johnson, Erin E Sizemore, William R Mac Kenzie
Moxifloxacin exhibits concentration-dependent prolongation of human QTc intervals and bactericidal activity against Mycobacterium tuberculosis However, moxifloxacin plasma concentrations are variable between patients. We evaluated whether human gene polymorphisms affect moxifloxacin plasma concentrations in tuberculosis patients from two geographic regions. We enrolled a convenience sample of 49 adults with drug-sensitive pulmonary tuberculosis from Africa and the United State s enrolled in two treatment trials of moxifloxacin as part of multidrug therapy...
February 20, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29463466/right-ventricular-dysfunction-in-congenitally-corrected-transposition-of-the-great-arteries-and-risk-of-ventricular-tachyarrhythmia-and-sudden-death
#14
Suraj Kapa, Vaibhav Vaidya, David O Hodge, Christopher J McLeod, Heidi M Connolly, Carole A Warnes, Samuel J Asirvatham
BACKGROUND: It is unknown whether systemic right ventricular (SRV) dysfunction confers increased risk for sudden death in congenitally corrected transposition of the great arteries (ccTGA). We sought to define risk of ventricular arrhythmias and sudden death attributable to systemic right ventricular dysfunction in ccTGA. METHODS: The study cohort is comprised of adult patients with a diagnosis of ccTGA. Clinical information and clinical outcomes including ICD therapy, incidence of VT/VF, and cause of death were reviewed...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29463075/adverse-effects-of-doping-with-anabolic-androgenic-steroids-aas-in-competitive-athletics-recreational-sports-and-bodybuilding
#15
Elena Vorona, Eberhard Nieschlag
Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. High doses of AAS cause a significant increase of erythrocytes und haemoglobin concentration, which may lead to thromboembolism, intracardiac thrombosis and stroke...
February 19, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29462915/pilocarpine-induced-status-epilepticus-is-associated-with-p-glycoprotein-induction-in-cardiomyocytes-electrocardiographic-changes-and-sudden-death
#16
Jerónimo Auzmendi, Bruno Buchholz, Jimena Salguero, Carlos Cañellas, Jazmín Kelly, Paula Men, Marcela Zubillaga, Alicia Rossi, Amalia Merelli, Ricardo J Gelpi, Alberto J Ramos, Alberto Lazarowski
Sudden unexpected death in epilepsy (SUDEP) is the major cause of death in those patients suffering from refractory epilepsy (RE), with a 24-fold higher risk relative to the normal population. SUDEP risk increases with seizure frequency and/or seizure-duration as in RE and Status Epilepticus (SE). P-glycoprotein (P-gp), the product of the multidrug resistant ABCB1-MDR-1 gene, is a detoxifying pump that extrudes drugs out of the cells and can confer pharmacoresistance to the expressing cells. Neurons and cardiomyocytes normally do not express P-gp, however, it is overexpressed in the brain of patients or in experimental models of RE and SE...
February 16, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29462825/golgi-fragmentation-in-human-patients-with-chronic-atrial-fibrillation-a-new-aspect-of-remodeling
#17
Luisa Jungk, Heike Franke, Aida Salameh, Stefan Dhein
BACKGROUND: Atrial fibrillation (AF) is the most common chronic arrhythmia in elderly people and is accompanied by remodeling processes. While much is known about changes in ionic channels and in extracellular matrix, less is known about possible changes of intracellular structures. OBJECTIVE: We wanted to investigate, whether AF may also affect the structure of the Golgi apparatus and the microtubular network. METHODS: One-hundred fifty-three cardiac surgery patients were investigated [ n = 24 in sinus rhythm (SR) and n = 129 with chronic AF of >1 year duration]...
February 20, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29461607/assessment-of-atrial-fibrillation-and-ventricular-arrhythmia-risk-in-patients-with-asthma-by-p-wave-corrected-qt-interval-dispersion
#18
H E Bozkurt Yilmaz, M Yilmaz, N Şen, C Altin, Z E Ünsal, A Tekin, Ş Akçay
OBJECTIVE: Although the relationship between obesity-asthma, obesity-atrial fibrillation (AF) and obesity-sudden cardiac death is clearly known, the risk of AF and ventricular arrhythmia has not been clearly determined in asthmatic patients. The aim of this study was to investigate whether AF, ventricular arrhythmia, and sudden cardiac death risk were increased in asthmatic patients using P wave dispersion (PWD) and corrected QT interval dispersion (CQTD). PATIENTS AND METHODS: The study was designed as a cross-sectional study...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461262/genetics-of-atrial-fibrillation-an-update
#19
Hannah M Campbell, Xander H T Wehrens
PURPOSE OF REVIEW: Atrial fibrillation is a common cardiac arrhythmia with a high morbidity and mortality affecting 34 million worldwide. Current therapies are inadequate and often fail to directly address molecular mechanisms of the disease. In this review, we will provide an overview of recent advances in our understanding of the genetic underpinnings of atrial fibrillation. RECENT FINDINGS: Large-scale genetic association studies have more than doubled the number of genetic loci associated with atrial fibrillation during the last year...
February 15, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29460900/-the-study-of-the-membrane-protective-potential-of-the-combination-of-2-ethyl-6-methyl-3-hydroxypyridine-succinate-and-citicoline
#20
E Yu Solovyeva, A N Karneev, A V Chekanov, O A Baranova, V A Shchelkonogov, A M Sinebryukhova, K I Farakhova, G M Sorokoumova
AIM: To assess the changes in the composition of plasma phospholipids in patients with chronic cerebrovascular disease treated with neuroprotectors 2-ethyl-6-methyl-3-hydroxypyridine succinate (neurox) and citicoline (neipilept), the natural metabolites involved in biochemical processes in the body, and their composition. MATERIAL AND METHODS: The study included 40 patients, 18 men and 22 women, aged from 54 to 72 years, with chronic cerebrovascular disease at the decompensation stage complicated with the hypertensive crisis and/or arrhythmia...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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