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https://www.readbyqxmd.com/read/28088535/neurobiological-consequences-of-juvenile-stress-a-gabaergic-perspective-on-risk-and-resilience
#1
REVIEW
Anne Albrecht, Iris Müller, Ziv Ardi, Gürsel Çalışkan, David Gruber, Sebastian Ivens, Menahem Segal, Joachim Behr, Uwe Heinemann, Oliver Stork, Gal Richter-Levin
ALBRECHT, A., MÜLLER, I., ARDI, Z., ÇALIŞKAN, G., GRUBER, D., IVENS, S., SEGAL, M., BEHR, J., HEINEMANN, U., STORK, O., and RICHTER-LEVIN, G. Neurobiological consequences of juvenile stress: a GABAergic perspective on risk and resilience. NEUROSCI BIOBEHAV REV XXX-XXX, 2016. - Childhood adversity is among the most potent risk factors for developing mood and anxiety disorders later in life. Therefore, understanding how stress during childhood shapes and rewires the brain may optimize preventive and therapeutic strategies for these disorders...
January 11, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28088534/the-social-transmission-of-metacontrol-policies-mechanisms-underlying-the-interpersonal-transfer-of-persistence-and-flexibility
#2
REVIEW
Bernhard Hommel, Lorenza S Colzato
Humans often face binary cognitive-control dilemmas, with the choice between persistence and flexibility being a crucial one. Tackling these dilemmas requires metacontrol, i.e., the control of the current cognitive-control policy. As predicted from functional, psychometric, neuroscientific, and modeling approaches, interindividual variability in metacontrol biases towards persistence or flexibility could be demonstrated in metacontrol-sensitive tasks. These biases covary systematically with genetic predispositions regarding mesofrontal and nigrostriatal dopaminergic functioning and the individualistic or collectivistic nature of the cultural background...
January 11, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28087766/control-of-amygdala-circuits-by-5-ht-neurons-via-5-ht-and-glutamate-co-transmission
#3
Ayesha Sengupta, Marco Bocchio, David M Bannerman, Trevor Sharp, Marco Capogna
: The serotonin (5-HT) system and the amygdala are key regulators of emotional behavior. Several lines of evidence suggest that 5-HT transmission in the amygdala is implicated in the susceptibility and drug treatment of mood disorders. Thus, elucidating the physiological mechanisms through which midbrain 5-HT neurons modulate amygdala circuits could be pivotal in understanding emotional regulation in health and disease. To shed light on these mechanisms, we performed patch-clamp recordings from basal amygdala (BA) neurons in brain slices from mice with channelrhodopsin (ChR2) genetically targeted to 5-HT neurons...
January 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28087404/mood-and-anxiety-disorders-precede-development-of-functional-gastrointestinal-disorders-in-patients-but-not-in-the-population
#4
Michael P Jones, Jan Tack, Lukas Van Oudenhove, Marjorie M Walker, Gerald Holtmann, Natasha A Koloski, Nicholas J Talley
BACKGROUND & AIMS: Understanding the interactions between brain and gastrointestinal disorders requires analysis of the order of disease onset. We analyzed data from 2 independent studies to determine the proportion of individuals with diagnoses of functional gastrointestinal disorders (FGIDs) before diagnoses of mood or anxiety disorders (gut to brain), and vice versa (brain to gut). METHODS: We collected data from a retrospective study of 4966 patients diagnosed with a FGID (irritable bowel syndrome, dyspepsia, or constipation) and mood or anxiety disorder at general practices in the United Kingdom (health care seekers) over an average period of 13...
January 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28087369/multidimensional-assessment-of-impulsivity-in-relation-to-obesity-and-food-addiction
#5
Lauren VanderBroek-Stice, Monika K Stojek, Steven R H Beach, Michelle R vanDellen, James MacKillop
Based on similarities between overconsumption of food and addictive drugs, there is increasing interest in "food addiction," a compulsive eating pattern defined using symptoms parallel to substance use disorders. Impulsivity, a multidimensional construct robustly linked to drug addiction, has been increasingly examined as an obesity determinant, but with mixed findings. This study sought to clarify relations between three major domains of impulsivity (i.e., impulsive personality traits, discounting of delayed rewards, and behavioral inhibition) in both obesity and food addiction...
January 10, 2017: Appetite
https://www.readbyqxmd.com/read/28087201/reduction-in-adolescent-depression-after-contact-with-mental-health-services-a-longitudinal-cohort-study-in-the-uk
#6
Sharon A S Neufeld, Valerie J Dunn, Peter B Jones, Tim J Croudace, Ian M Goodyer
BACKGROUND: Evidence regarding the association between service contact and subsequent mental health in adolescents is scarce, and previous findings are mixed. We aimed to longitudinally assess the extent to which depressive symptoms in adolescents change after contact with mental health services. METHODS: As part of a longitudinal cohort study, between April 28, 2005, and March 17, 2010, we recruited 1238 14-year-old adolescents and their primary caregivers from 18 secondary schools in Cambridgeshire, UK...
January 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28086827/mothers-accounts-of-the-impact-on-emotional-wellbeing-of-organised-peer-support-in-pregnancy-and-early-parenthood-a-qualitative-study
#7
Jenny McLeish, Maggie Redshaw
BACKGROUND: The transition to parenthood is a potentially vulnerable time for mothers' mental health and approximately 9-21% of women experience depression and/or anxiety at this time. Many more experience sub-clinical symptoms of depression and anxiety, as well as stress, low self-esteem and a loss of confidence. Women's emotional wellbeing is more at risk if they have little social support, a low income, are single parents or have a poor relationship with their partner. Peer support can comprise emotional, affirmational, informational and practical support; evidence of its impact on emotional wellbeing during pregnancy and afterwards is mixed...
January 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28086766/psychoeducational-preventive-treatment-for-women-at-risk-of-postpartum-depression-study-protocol-for-a-randomized-controlled-trial-progea
#8
Amaia Ugarte Ugarte, Purificación López-Peña, Carmen Serrulla Vangeneberg, Julia Gemma Torregaray Royo, Maria Asunción Arrieta Ugarte, Maria Teresa Zabalza Compains, Maria Pilar Riaño Medrano, Nerea Muñoz Toyos, Edurne Arenaza Lamo, Maria Begoña Beneitez Dueñas, Ana González-Pinto
BACKGROUND: Postpartum depression is a disease with a prevalence of 20% that has deleterious consequences not only for the mother but also for the baby and can cause delays in physical, social and cognitive development. In this context, the European Union Committee on Public Health has declared it essential that preventative measures are taken by centres providing care for women with a multidisciplinary approach. PROGEA is a multicentre, single-blind randomized, 3-year, longitudinal clinical trial aiming to evaluate the efficacy of a psychoeducational programme in preventing postpartum depression in at-risk women, based on a range of clinical variables, and explore prognostic factors...
January 13, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28080264/convergent-and-criterion-validity-of-the-cogstate-computerized-brief-battery-cognitive-assessment-in-women-with-and-without-breast-cancer
#9
Sunita K Patel, Adrienne M Meier, Nathaniel Fernandez, Tracy T Y Lo, Colleen Moore, Nicole Delgado
OBJECTIVE: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional 'pencil and-paper' neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized tests in breast cancer survivors, a group known to present with mostly mild, subtle cognitive dysfunction...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28080107/feasibility-and-adherence-paradigm-to-ecological-momentary-assessments-in-urban-minority-youth
#10
Mariya P Shiyko, Seth Perkins, Linda Caldwell
All adolescents in general, including ethnic and racial minorities, report high levels of cell phone use, making mobile technology a useful tool for assessment and intervention. Known health and education disparities based on minority status motivated us to conduct an in-depth investigation regarding feasibility of and adherence to the ecological momentary assessment (EMA) research protocol, studying daily life of urban minority youth. In addition, this paper presents a methodological approach to conceptualizing and reporting adherence in EMA studies...
January 12, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28079769/posttraumatic-stress-disorder-relapse-and-clitoral-reconstruction-after-female-genital-mutilation
#11
Jasmine Abdulcadir, Francesco Bianchi Demicheli, Alexia Willame, Nathalie Recordon, Patrick Petignat
BACKGROUND: Evidence on clitoral reconstruction after female genital mutilation is lacking. CASE: A woman with female genital mutilation experiencing clitoral pain during sex consulted to undergo clitoral reconstruction. The surgery was complicated by a wound infection responsible for severe postoperative pain. Such genital pain made our patient recall the traumatic experience of genital mutilation and experience a relapse of posttraumatic stress disorder symptoms...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079649/factors-affecting-the-ability-of-people-with-diabetes-to-avoid-hypoglycemia
#12
Fei-Ling Wu, En-Chang Wu, Yue-Cune Chang, Wen-Yu Hu, Jyuhn-Huarng Juang, Mei Chang Yeh
BACKGROUND: Hypoglycemia is recognized as a limiting factor in diabetes management. Fear of experiencing hypoglycemia may lead to lower quality of life, impaired glycemic control, and emotional distress, all of which impair the ability of patients to self-manage their diabetes effectively. Problem solving is central to diabetes self-management and may help patients achieve effective self-care of their disease. PURPOSE: The aim of this study was to investigate the ability of people with diabetes to avoid hypoglycemia and to explore associated factors...
January 11, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28079600/acute-administration-of-cyclosporine-a-does-not-impair-attention-or-memory-performance-in-healthy-men
#13
Anna L Kahl, Julia Kirchhof, Anna Füting, Bernd-Otto Hütter, Benjamin Wilde, Oliver Witzke, Sven Benson, Martin Hadamitzky, Manfred Schedlowski
There is clinical and experimental evidence that treatment with immunosuppressive and antiproliferative drugs such as the calcineurin inhibitor cyclosporine A (CsA) is associated with mental health problems and neuropsychological disturbances in patients. However, it remains unclear whether and to what extent cognitive functions such as memory and attention processes are affected by the pharmacological treatment. This is partly because of the fact that it is difficult to refer the observed neuropsychological disturbances in patients to the drug itself, to drug-induced immune suppression, or to interaction with other medication or comorbidities...
January 11, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28079488/association-analysis-of-ank3-variants-with-bipolar-disorder-in-the-korean-population
#14
Chul-Hyun Cho, Soojin Kim, Dongho Geum, Heon-Jeong Lee
BACKGROUND: Bipolar disorder (BD) is a major psychiatric disorder characterized by alternating mood episodes, including major depressive, hypomanic, and manic episodes. Previous genetic studies of BD have reported several genes as potentially associated with BD. The ANK3 gene has been identified as a possible BD susceptibility gene in genome-wide association analyses. AIMS: The goal of the present study was to evaluate the association of ANK3 variants with BD in the Korean population...
January 12, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28078988/bdnf-nf-kb-signaling-in-the-neurobiology-of-depression
#15
Ariel Caviedes, Carlos Lafourcade, Claudio Soto, Ursula Wyneken
BACKGROUND: Mood disorders, consisting of unipolar and bipolar depression, are complex diseases characterized by depressed mood and anhedonia. These core symptoms are accompanied in a varying manner by anxiety, several neurovegetative symptoms and cognitive impairment. Mood disorders are characterized by decreases in neurogenesis, alteration in synaptic structure and synaptic transmission, all of them regulated by BDNF, a neurotrophin that performs multiple functions in the adult central nervous system...
January 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28078214/pharmacology-of-testosterone-replacement-therapy-preparations
#16
REVIEW
Jennifer J Shoskes, Meghan K Wilson, Michael L Spinner
The goal of testosterone replacement therapy (TRT) is to return serum testosterone levels to within physiologic range and improve symptoms in hypogonadal men. Some of the symptoms aimed to improve upon include decreased libido, erectile dysfunction, infertility, hot flashes, depressed mood, and loss of muscle mass or hair. Clinical use of testosterone for replacement therapy began approximately 70 years ago. Over the decades, numerous preparations and formulations have been developed primarily focusing on different routes of delivery and thus pharmacokinetics (PKs)...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078206/infectious-atopic-and-inflammatory-diseases-childhood-adversities-and-familial-aggregation-are-independently-associated-with-the-risk-for-mental-disorders-results-from-a-large-swiss-epidemiological-study
#17
Vladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Margot Mutsch, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Enrique Castelao, Marie-Pierre F Strippoli, Caroline Vandeleur, Roland von Känel, Rosa Paolicelli, Markus A Landolt, Cornelia Witthauer, Roselind Lieb, Martin Preisig
AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28077452/does-it-matter-if-we-disagree-the-impact-of-incongruent-care-preferences-on-persons-with-dementia-and-their-care-partners
#18
Evan G Shelton, Silvia Orsulic-Jeras, Carol J Whitlatch, Sarah M Szabo
PURPOSE: To gain a better understanding of how actual and perceived incongruence of care preferences affects the psychosocial well-being of persons with dementia and their family caregiver. DESIGN AND METHODS: In-depth interviews were conducted with 128 dyads each consisting of a person with dementia and a family caregiver. Baseline data from an intervention study were used to examine the relationship between the caregiver's care-related preferences, the person with dementia's care-related preferences, and the caregiver's perception of the person with dementia's preferences...
January 10, 2017: Gerontologist
https://www.readbyqxmd.com/read/28077345/tips-and-traps-lessons-from-codesigning-a-clinician-e-monitoring-tool-for-computerized-cognitive-behavioral-therapy
#19
Frederick Sundram, Susan J Hawken, Karolina Stasiak, Mathijs Fg Lucassen, Theresa Fleming, Matthew Shepherd, Andrea Greenwood, Raechel Osborne, Sally N Merry
BACKGROUND: Computerized cognitive behavioral therapy (cCBT) is an acceptable and promising treatment modality for adolescents with mild-to-moderate depression. Many cCBT programs are standalone packages with no way for clinicians to monitor progress or outcomes. We sought to develop an electronic monitoring (e-monitoring) tool in consultation with clinicians and adolescents to allow clinicians to monitor mood, risk, and treatment adherence of adolescents completing a cCBT program called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts)...
January 11, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28077219/cognitive-behavioral-therapy-for-depression-using-mind-over-mood-cbt-skill-use-and-differential-symptom-alleviation
#20
Lance L Hawley, Christine A Padesky, Steven D Hollon, Enza Mancuso, Judith M Laposa, Karen Brozina, Zindel V Segal
Cognitive-behavioral therapy (CBT) for depression is highly effective. An essential element of this therapy involves acquiring and utilizing CBT skills; however, it is unclear whether the type of CBT skill used is associated with differential symptom alleviation. Outpatients (N = 356) diagnosed with a primary mood disorder received 14 two-hour group sessions of CBT for depression, using the Mind Over Mood protocol. In each session, patients completed the Beck Depression Inventory and throughout the week they reported on their use of CBT skills: behavioral activation (BA), cognitive restructuring (CR), and core belief (CB) strategies...
January 2017: Behavior Therapy
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