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Ashley Vena, Andrea King, Royce Lee, Harriet de Wit
INTRODUCTION: Preclinical and clinical evidence suggest that the neuropeptide oxytocin may be of value in treating alcohol use disorder, either by reducing the rewarding effects of alcohol or reducing negative affect induced by alcohol withdrawal. However, the effect of a single dose of oxytocin on subjective and psychomotor responses to alcohol in social drinkers is not known. METHODS: The present study examined the effect of intranasal oxytocin on subjective, behavioral, and physiological responses to a moderate dose of alcohol (0...
June 19, 2018: Alcoholism, Clinical and Experimental Research
Mao-Hsuan Huang, Yu-Chuan Chiu, Chia-Fen Tsai
PLA2G6-associated neurodegeneration is a major subtype of neurodegeneration with brain iron accumulation. Patients with PLA2G6-associated neurodegeneration usually present degenerative motor symptoms with neuropsychiatric disturbance. This report presents a patient with PLA2G6-related dystonia-parkinsonism, who had neuropsychiatric symptoms preceding movement symptoms. Antipsychotic drug was prescribed, and he developed parkinsonism years later. Differential diagnosis between drug-induced parkinsonism and PLA2G6-related dystonia-parkinsonism could be challenging...
June 18, 2018: Clinical Neuropharmacology
Cinzia Grassi, Antonio Del Casale, Stefano Ferracuti, Petri Cucè, Roberto Santorsa, Andrea Pelliccione, Gemma Marotta, Giuseppe Tavella, Roberto Tatarelli, Paolo Girardi, Chiara Rapinesi, Georgios D Kotzalidis, Maurizio Pompili
BACKGROUND: Suicide in international police is 2-3-fold that of the general population. Risk factors include suicidal ideation, diagnosis of mood or post-traumatic stress disorders, family/psychological problems, suffered abuse, alcohol use, service suspension, and stigma. A false stigma-related myth is to believe that suicide does not cause concern within military settings. METHODS: We administered post-training to 6103 Italian Police workers a 30-item questionnaire to assess the perception of suicidal phenomena...
April 2018: Annali Dell'Istituto Superiore di Sanità
Hande Gezer, Ozgur Zeliha Karaahmet, Eda Gurcay, Deniz Dulgeroglu, Aytul Cakci
BACKGROUND AND AIMS: To compare the effects of aerobic exercise and conventional exercise that were applied during the rehabilitation process on the aerobic capacity, motor function, activity limitation, quality of life, depression level, and sleep quality in subacute stroke patients. METHODS: The patients were divided into two groups; aerobic exercise group (n = 22) or conventional exercise group (n = 20). Both groups participated in a conventional stroke rehabilitation program; however, aerobic exercise program was applied only for the patients in group 1...
June 19, 2018: Irish Journal of Medical Science
Barbara Grabowska-Fudala, Krystyna Jaracz, Krystyna Górna, Izabela Miechowicz, Izabela Wojtasz, Jan Jaracz, Radosław Kaźmierski
INTRODUCTION: This is a prospective study, first to compare the frequency of depressive symptoms in stroke survivors treated, and non-treated, with intravenous thrombolysis and second, to explore relationships between post-stroke depression (PSD) and stroke treatment modalities, taking into account other possible determinants of PSD, including post-traumatic stress symptoms. METHODS: Groups of 73 thrombolysed and 73 non-thrombolysed patients matched for age and gender were examined at 3 and 12 months after discharge...
June 18, 2018: Journal of Neurology
Ricardo B Viana, Paulo Gentil, Vinício S Lorenço, Carlos A Vieira, Mário H Campos, Douglas A T Santos, Wellington F Silva, Marilia S Andrade, Rodrigo L Vancini, Claudio A B de Lira
Background: It is possible that physical education professionals, especially those who participate in aerobic activities, have predisposing factors, signs and symptoms of overreaching (OVR) and overtraining (OVT) due to a high load and volume of exercise followed by suboptimal recovery time. The present study aimed to identify the predisposing factors, signs and symptoms of OVR and OVT in physical education professionals. Methods: A questionnaire consisting of 42 questions (10 questions group) about predisposing factors and signs/symptoms was answered by 132 physical education professionals from both sexes (83 men and 49 women) who were allocated into a resistance training group (RG, n  = 74), aerobic training group (AG, n  = 20) and resistance and aerobic training group (RAG, n  = 38)...
2018: PeerJ
Hamdi Cihan Emeksiz, Aysun Bideci, Burçin Nalbantoğlu, Ayşin Nalbantoğlu, Cem Çelik, Yasemin Yulaf, Mahmut Orhun Çamurdan, Peyami Cinaz
Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) have higher levels of anxiety and depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist in adolescents affected by PCOS. The aim of the present study is to assess differences in anxiety and depression levels between adolescents with PCOS and age- and body mass index (BMI)-matched controls and to determine the possible factor(s) impacting these psychological parameters in adolescents with PCOS...
June 14, 2018: Turkish Journal of Medical Sciences
Craig P Hutton, Jennifer A Lemon, Boris Sakic, C David Rollo, Douglas R Boreham, Margaret Fahnestock, J Martin Wojtowicz, Suzanna Becker
The increasing global burden of Alzheimer's disease (AD) and failure of conventional treatments to stop neurodegeneration necessitates an alternative approach. Evidence of inflammation, mitochondrial dysfunction, and oxidative stress prior to the accumulation of amyloid-β in the prodromal stage of AD (mild cognitive impairment; MCI) suggests that early interventions which counteract these features, such as dietary supplements, may ameliorate the onset of MCI-like behavioral symptoms. We administered a polyphenol-containing multiple ingredient dietary supplement (MDS), or vehicle, to both sexes of triple transgenic (3xTg-AD) mice and wildtype mice for 2 months from 2-4 months of age...
June 9, 2018: Journal of Alzheimer's Disease: JAD
Lasse M Giil, Dag Aarsland, Kristoffer Hellton, Anders Lund, Harald Heidecke, Kai Schulze-Forster, Gabriela Riemekasten, Audun Osland Vik-Mo, Einar K Kristoffersen, Christian A Vedeler, Jan Erik Nordrehaug
BACKGROUND: Endogenous antibodies to signaling molecules and receptors (Abs) are associated with Alzheimer's disease (AD). OBJECTIVES: To investigate the association of 33 Abs to dopaminergic, serotoninergic, muscarinic, adrenergic, vascular, and immune receptors with cognitive, neuropsychiatric, and mortality outcomes. METHODS: Ninety-one patients with mild AD were followed annually for 5 years with the Mini-Mental State Examination (MMSE) and the Neuropsychiatric Inventory (NPI; composite outcomes: "psychosis" (item 1 + 2), "mood" (item 4 + 5 + 7), and "agitation" (item 3 + 8 + 9))...
June 9, 2018: Journal of Alzheimer's Disease: JAD
Sigridur Gunnarsdottir, Sandra E Ward, Ronald C Serlin
Prevalence estimates of pain differ depending on how it is defined and measured and on the populations studied. It has been estimated that on a given day, as many as 30-44% of the general population experience some kind of pain. Information about the prevalence of pain in Iceland is not available. The aims of this study were to evaluate the prevalence of pain of various origins among the general population of Iceland, to test hypotheses regarding relationships between pain, quality of life (QOL) and demographic variables, to evaluate participants' beliefs about causes of their pain, and to evaluate how those who experience pain manage it...
December 29, 2017: Scandinavian Journal of Pain
Steven J Linton
Background and aims Chronic pain patients often present with a host of psychological and somatic problems and are unable to work despite receiving traditional pain management. For example, it is common that patients with persistent pain also suffer from a variety of anxiety and depressive symptoms. Indeed, the regulation of emotions may be one important factor that is associated with the development of persistent pain. Dialectical behavior therapy, a form of cognitive-behavioral therapy, focuses on emotion regulation and has successfully addressed other complex problems...
December 29, 2017: Scandinavian Journal of Pain
Jarkko Kalliomäki, Märta Segerdahl, Lynn Webster, Annika Reimfelt, Karin Huizar, Peter Annas, Rolf Karlsten, Hans Quiding
Aim To evaluate the analgesic efficacy of AZD1940, a novel peripherally acting cannabinoid CB1/CB2 receptor agonist, in patients undergoing third molar surgical removal. Methods This was a randomized, double-blind, placebo-controlled study in patients scheduled for surgical removal of an impacted lower third molar. Patients received a single oral dose of 800 μg AZD1940, 500 mg naproxen or placebo 1.5 h before surgery. The dose of 800 μg AZD1940 was selected based on earlier data from a single dose study in man, in which it was identified as the highest well tolerated dose...
December 29, 2017: Scandinavian Journal of Pain
E Horjales, N B Finnerup, T S Jensen, P Svensson
Background/aims Previous studies have focused on the effect of negative emotions generated by music, pictures or odours on pain perception. This study tested whether emotionally loaded visual and gustatory stimuli could influence experimental tonic jaw muscle pain in healthy subjects. Methods 32 healthy subjects (16 men, 16 women; 18-39 years old) participated. In two sessions experimental jaw muscle pain was evoked by injection of 0.2 ml hypertonic saline into the masseter muscle. In the first session with each injection an emotion (positive, negative or neutral) was generated by visual stimuli (pictures taken from International Affective Picture System)...
December 29, 2017: Scandinavian Journal of Pain
Harald Breivik
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
C Peter, N Watson
Background The use of opioids for chronic non-cancer pain (CNCP) remains very controversial. There are a number of randomized controlled trials (RCTs) showing efficacy and safety in the short-term, but long-term data are limited. Methods This article contains 10 case reports (followed to 2011) that were selected from a survey of 84 patients with intractable CNCP treated with opioids and followed every 3 months now for a median of 10 years. The previous published survey of this group reported outcomes of pain severity, adverse effects, pain relief, satisfaction, mood, problematic opioid use, tolerance, physical dependency, functional status, health-related quality of life (HRQL), immune status and sexual function...
December 29, 2017: Scandinavian Journal of Pain
Steven J Linton, Sofia Bergbom
Background and aims Patients seeking care for a pain problem very often also report symptoms of depression.In fact, depression is associated with the development of chronic pain as well as poor treatment results. Yet, the mechanisms by which depression and pain impact upon one another are not clear. This paper provides a critical review of the literature with the aim of shedding light on the relationship between pain and depression. Further, we introduce the Örebro Behavioral Emotion Regulation Model which may stimulate understanding in addition to research...
December 29, 2017: Scandinavian Journal of Pain
Niklas Stabell, Trond Flægstad, Audun Stubhaug, Christopher Sivert Nielsen
Background and aims The prevalence of depression is increased among patients with abdominal pain (AP) and Irritable Bowel Syndrome (IBS), but little is known about this association among adolescents in the general population. Furthermore, there is considerable uncertainty about exactly which dimensions of AP and IBS are associated with depression. The aims of this study were therefore: (a) to describe the prevalence of AP, IBS and depression in a representative sample of adolescents, (b) to analyze the association of AP and IBS with depression and lastly, (c) to analyze the relationship between depression and specific AP and IBS symptom dimensions, i...
December 29, 2017: Scandinavian Journal of Pain
Heinrich Wernze, Thomas Herdegen
Objective No single drug is broadly efficacious in the long-term treatment of fibromyalgia syndrome (FMS). Spironolactone is known to ameliorate mood and tension headache or migraine in women with premenstrual syndrome or clinical signs of hyperandrogenism. In a case series of women with treatment resistant FMS spironolactone was therefore added to their medication, and they were observed for at least 12 months. Methods 31 women with treatment-resistant FMS received spironolactone as add-on medication to various pain modulating drugs...
December 29, 2017: Scandinavian Journal of Pain
Ulrike Zetsche, Paul-Christian Bürkner, Lars Schulze
Individuals who experience recurrent negative thoughts are at elevated risk for mood and anxiety disorders. It is thus essential to understand why some individuals get stuck in recurrent negative thinking (RNT), whereas others are able to disengage eventually. Theoretical models propose that individuals high in recurrent negative thinking suffer from deficits in controlling the contents of working memory. Empirical findings, however, are inconclusive. In this meta-analysis, we synthesize findings from 94 studies to examine the proposed association between RNT and deficits in cognitive control...
June 11, 2018: Clinical Psychology Review
Livia Navon
OBJECTIVES: To understand trends in health care use among people living with HIV/AIDS (PLWHA), this study compared trends in hospitalization rates, comorbidities, and hospital death rates of hospitalized PLWHA with the overall hospitalized population in Illinois during 2008-2014. METHODS: This study identified principal hospitalizations (the principal discharge diagnosis coded with an HIV-related billing code) and secondary HIV hospitalizations (a non-principal discharge diagnosis coded with an HIV-related billing code) from 2008-2014 Illinois hospital discharge data...
January 1, 2018: Public Health Reports
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