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https://www.readbyqxmd.com/read/29677623/cerebrospinal-fluid-fgf23-levels-correlate-with-a-measure-of-impulsivity
#1
Hui Li, Zhiyong Cao, Jinzhong Xu, Fan Wang, Rongrong Xiong, Zeping Xu, Xianming Luo, Guohua Li, Xingqi Tan, Zhiyang Liu, Zhiqin Gao, Yimin Kang, Jian Xiao, Yanlong Liu, Xiaokun Li
Fibroblast growth factor 23 (FGF23) is a bone-derived protein produced mainly by osteocytes and osteoblasts and at low levels in specific parts of the brain. It has been shown to associate with mood regulation. Lithium treatment gives rise to significant elevations of serum FGF23 levels in depressive patients. High peripheral blood FGF23 levels correlated with poor cognitive performance in hemodialysis patients. However, no direct evidence demonstrates a relationship between FGF23 and mood regulation. In this study, we aimed to measure the concentration of cerebrospinal fluid (CSF) FGF23 and to explore its relationship with a cluster of emotional characteristics...
April 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29676337/familial-aggregation-of-mood-disorders-among-relatives-of-schizophrenia-probands-admitted-in-a-hospital-in-south-eastern-nigeria-a-family-comparative-study
#2
Justus Uchenna Onu, Jude Uzoma Ohaeri
Introduction: The debate on the current nosological status of schizophrenia and mood disorders as distinct entities is very active among scholars. There is a paucity of genetic epidemiological data to contribute an African perspective to this debate. Aim: This study aimed to assess the morbid risk of mood disorders in the relatives of schizophrenia probands, in comparison with the families of a sample of healthy controls. Subjects and Methods: This study elicited the information on the morbid risk of mood disorders among 5259 relatives of schizophrenia probands (n = 138) and 6734 relatives of healthy controls (n = 138) through direct interview of patients, available relatives of patients and the comparison group...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675582/multifunctional-opioid-ligands
#3
Jessica P Anand, Deanna Montgomery
The opioid receptor system plays a major role in the regulation of mood, reward, and pain. The opioid receptors therefore make attractive targets for the treatment of many different conditions, including pain, depression, and addiction. However, stimulation or blockade of any one opioid receptor type often leads to on-target adverse effects that limit the clinical utility of a selective opioid agonist or antagonist. Literature precedent suggests that the opioid receptors do not act in isolation and that interactions among the opioid receptors and between the opioid receptors and other proteins may produce clinically useful targets...
April 20, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29675463/caregiver-burden-and-caregiver-appraisal-of-psychiatric-symptoms-are-not-modulated-by-subthalamic-deep-brain-stimulation-for-parkinson-s-disease
#4
Philip E Mosley, Michael Breakspear, Terry Coyne, Peter Silburn, David Smith
Subthalamic deep brain stimulation is an advanced therapy that typically improves quality of life for persons with Parkinson's disease (PD). However, the effect on caregiver burden is unclear. We recruited 64 persons with PD and their caregivers from a movement disorders clinic during the assessment of eligibility for subthalamic DBS. We used clinician-, patient- and caregiver-rated instruments to follow the patient-caregiver dyad from pre- to postoperative status, sampling repeatedly in the postoperative period to ascertain fluctuations in phenotypic variables...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29674601/the-relationship-between-the-number-of-manic-episodes-and-oxidative-stress-indicators-in-bipolar-disorder
#5
Süleyman Akarsu, Abdullah Bolu, Emre Aydemir, Selma Bozkurt Zincir, Yasemin Gülcan Kurt, Serkan Zincir, Murat Erdem, Özcan Uzun
Objective: Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes that has a lifetime prevalence of 0.4- 5.5%. The neurochemical mechanism of BD is not fully understood. Oxidative stress in neurons causes lipid peroxidation in proteins associated with neuronal membranes and intracellular enzymes and it may lead to dysfunction in neurotransmitter reuptake and enzyme activities. These pathological processes are thought to occur in brain regions associated with affective functions and emotions in BD...
April 20, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29674252/predicting-enrollment-in-two-randomized-controlled-trials-of-nonpharmacologic-interventions-for-youth-with-primary-mood-disorders
#6
Andrea S Young, Adina M Seidenfeld, K Zachary Healy, L Eugene Arnold, Mary A Fristad
BACKGROUND: As recruitment and retention are often challenging in randomized controlled trials (RCTs), this study sought to identify predictors of participation (i.e., trial enrollment). METHOD: These analyses identified predictors of enrollment among 119 youth, ages 7-14, with a primary mood disorder, who screened eligible for the Omega-3 and Therapy pilot studies; 95 (79.8%) actually participated in the treatment. RESULTS: Youth who received some form of travel assistance (16...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29674225/mood-and-restrained-eating-moderate-food-associated-response-inhibition-in-obese-individuals-with-binge-eating-disorder
#7
Sabine Loeber, Martina Rustemeier, Georgios Paslakis, Reinhard Pietrowsky, Astrid Müller, Stephan Herpertz
Recent research suggests that obese individuals with binge eating disorder (BED) show deficits in response inhibition, but findings are not consistent, especially when food-associated stimuli are presented. The aim of the present study was to assess the role of moderating factors by taking into account restrained eating and mood. Seventeen obese women with BED, 20 obese women without BED and 20 normal-weight controls (NW) were recruited. A go/no-go task with food-associated and control stimuli and questionnaires were administered...
March 30, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29673965/a-review-on-neuroimaging-studies-of-genetic-and-environmental-influences-on-early-brain-development
#8
REVIEW
Wei Gao, Karen Grewen, Rebecca C Knickmeyer, Anqi Qiu, Andrew Salzwedel, Weili Lin, John H Gilmore
The past decades witnessed a surge of interest in neuroimaging study of normal and abnormal early brain development. Structural and functional studies of normal early brain development revealed massive structural maturation as well as sequential, coordinated, and hierarchical emergence of functional networks during the infancy period, providing a great foundation for the investigation of abnormal early brain development mechanisms. Indeed, studies of altered brain development associated with either genetic or environmental risks emerged and thrived...
April 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29673929/sleep-disorders-in-adolescents-and-young-adults-insights-into-types-relationship-to-obesity-and-high-altitude-and-possible-lines-of-management
#9
REVIEW
Ahmed M Kabel, Amani M Al Thumali, Khayriah A Aldowiala, Raghad D Habib, Shoroq S Aljuaid, Huda A Alharthi
A sleep disorder is a medical disorder of the sleep pattern of a person that may be serious enough to interfere with normal physical, mental and emotional functioning. Disruptions in sleep can be caused by a variety of causes, from teeth grinding to night terrors. Sleep disorders are usually prevalent among adolescents and young adults, possibly due to factors related to life style, dietary habits, hormonal and emotional disturbances. Other factors that may precipitate sleep disorders include environmental, psychological and genetic factors...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29673620/effects-of-opioid-and-non-opioid-analgesics-on-responses-to-psychosocial-stress-in-humans
#10
Anya K Bershad, Melissa A Miller, Greg J Norman, Harriet de Wit
Both preclinical and clinical evidence suggests that the endogenous opioid system is involved in responses to stress. For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress. We recently reported that the mixed mu agonist and kappa antagonist buprenorphine dampened responses to acute psychosocial stress in humans. Now we extend this to study the effects of a pure mu-opioid agonist, hydromorphone, and a non-opioid analgesic, acetaminophen, on response to social stress...
April 16, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29673379/erythropoietin-as-an-add-on-treatment-for-cognitive-side-effects-of-electroconvulsive-therapy-a-study-protocol-for-a-randomized-controlled-trial
#11
Lejla Sjanic Schmidt, Jeff Zarp Petersen, Maj Vinberg, Ida Hageman, Niels Vidiendal Olsen, Lars Vedel Kessing, Martin Balslev Jørgensen, Kamilla Woznica Miskowiak
BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but its use is impeded by its cognitive side effects. Novel treatments that can counteract these side effects may therefore improve current treatment strategies for depression. The present randomized trial investigates (1) whether short-term add-on treatment with erythropoietin (EPO) can reduce the cognitive side -effects of ECT and (2) whether such effects are long-lasting. Further, structural and functional magnetic resonance imaging (MRI) will be used to explore the neural underpinnings of such beneficial effects of EPO...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29673132/the-effects-of-vortioxetine-on-cognitive-dysfunction-in-patients-with-inadequate-response-to-current-antidepressants-in-major-depressive-disorder-a-short-term-randomized-double-blind-exploratory-study-versus-escitalopram
#12
Eduard Vieta, Lasse B Sluth, Christina K Olsen
BACKGROUND: Major Depressive Disorder (MDD) is a heterogeneous disease characterized by emotional, physical and cognitive symptoms. This study explored the effects of vortioxetine versus escitalopram on outcomes of cognition, functioning and mood symptoms in depressed patients with inadequate response to current antidepressant treatment. METHODS: In this parallel-group, active-comparator study, adult patients (18-65 years, N = 101) with MDD, with inadequate response to current antidepressant monotherapy, were randomized 1:1 to 8 weeks' double-blind treatment with flexible doses (10-20mg/day) of either vortioxetine or escitalopram...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29673069/short-term-memory-impairment-in-vestibular-patients-can-arise-independently-of-psychiatric-impairment-fatigue-and-sleeplessness
#13
Laura Smith, David Wilkinson, Mayur Bodani, Rowena Bicknell, S S Surenthiran
Vestibular dysfunction is associated with visual short-term memory impairment; however, it remains unclear if this impairment arises as a direct result of the vestibular dysfunction or is a consequence of comorbid changes in mood, affect, fatigue, and/or sleep. To this end, we assessed the concurrence and interdependence of these comorbidities in 101 individuals recruited from a tertiary balance clinic with a neuro-otological diagnosis. Over fifty per cent of the sample showed reduced visuospatial short-term memory, 60% and 37% exceeded cut-off on the Beck Anxiety and Depression Inventories, respectively, 70% exceeded cut-off on the Fatigue Severity Scale, 44% reported daytime sleepiness on the Epworth Sleepiness Scale, and 78% scored above cut-off on the Pittsburgh Sleep Quality Index...
April 19, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29672965/acute-hematological-and-mood-perception-effects-of-bitter-orange-extract-p-synephrine-consumed-alone-and-in-combination-with-caffeine-a-placebo-controlled-double-blind-study
#14
Jill A Bush, Nicholas A Ratamess, Sidney J Stohs, Nicole L Ellis, Ira T Vought, Elizabeth A O'Grady, Jeremy D Kuper, Jie Kang, Avery D Faigenbaum
The purpose of this study was to examine acute hematological and mood perception responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects visited the laboratory on 6 occasions and were given (in randomized double-blind manner) 103-mg p-synephrine (S), 233-mg caffeine + 104-mg p-synephrine, 240-mg caffeine, 337-mg caffeine + 46-mg p-synephrine, 325-mg caffeine, or a placebo (PL). The subjects sat quietly for 3 hr while completing mood state questionnaires every 30 min...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29672801/antisuicidal-effects-in-mood-disorders-are-they-unique-to-lithium
#15
Leonardo Tondo, Ross J Baldessarini
INTRODUCTION: Suicidal behavior is strongly associated with depression in major depressive (MDD) and bipolar (BD) disorders, especially with associated behavioral activation, dysphoria, or agitation. A rare intervention with evidence of suicide risk-reducing as well as mood-stabilizing effects in mood disorder patients is lithium. METHODS: We reviewed available research evidence on associations of long-term treatment with lithium with risk of suicidal behavior. We meta-analyzed 12 randomized trials in 10 reports (with at least 1 suicide in either treatment arm) including both BD and MDD subjects, with particular attention to comparisons of lithium with placebo or other pharmacological treatments...
April 19, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29672106/mmpi-2-rf-characteristics-of-veterans-seeking-treatment-for-military-sexual-trauma
#16
Eliza S McManus, Lisa-Ann J Cuccurullo, Madeline Uddo, C Laurel Franklin
Military sexual trauma (MST) is defined as experiences of sexual assault or repeated, threatening, harassment during military service. MST events may not qualify within posttraumatic stress disorder (PTSD) Criterion A, making symptoms associated with MST unique from trauma-related disorders. Little research has been done to understand those presenting for MST treatment. Thus, this article provides Minnesota Multiphasic Personality Inventory 2-Restructured Form (MMPI-2-RF) scores of 33 U.S. veterans who experienced MST in an effort to better understand psychological and personality characteristics of this important and unique group of veterans...
April 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29671235/evaluation-of-neurotransmitter-alterations-in-four-distinct-brain-regions-after-rapid-eye-movement-sleep-deprivation-remsd-induced-mania-like-behaviour-in-swiss-albino-mice
#17
Saiful Alom Siddique, Thangavel Tamilselvan, Manikkannan Vishnupriya, Elumalai Balamurugan
A number of neurotransmitter systems have been implicated in contributing to the pathology of mood disorders, including those of dopamine (DA), serotonin (5-HT), norepinephrine (NE) and γ-aminobutyric acid (GABA). Rapid eye movement sleep deprivation (REMSD) alters most of the neurotransmitters, which may have adverse behavioural changes and other health consequences like mania and other psychiatric disorders. The exact role of REMSD altered neurotransmitter levels and the manner in which emerging consequences lead to mania-like behaviour is poorly understood...
April 18, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29670554/mood-detection-in-ambiguous-messages-the-interaction-between-text-and-emoticons
#18
Nerea Aldunate, Mario Villena-González, Felipe Rojas-Thomas, Vladimir López, Conrado A Bosman
Face-to-face communication has several sources of contextual information that enables language comprehension. This information is used, for instance, to perceive mood of interlocutors, clarifying ambiguous messages. However, these contextual cues are absent in text-based communication. Emoticons have been proposed as cues used to stress the emotional intentions on this channel of communication. Most studies have suggested that their role is to contribute to a more accurate perception of emotions. Nevertheless, it is not clear if their influence on disambiguation is independent of their emotional valence and its interaction with text message valence...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29670494/social-identity-in-people-with-multiple-sclerosis-an-examination-of-family-identity-and-mood
#19
Alex B Barker, Nadina B Lincoln, Nigel Hunt, Roshan dasNair
Background: Mood disorders are highly prevalent in people with multiple sclerosis (MS). MS causes changes to a person's sense of self. The Social Identity Model of Identity Change posits that group membership can have a positive effect on mood during identity change. The family is a social group implicated in adjustment to MS. The objectives of this study were to investigate whether family identity can predict mood in people with MS and to test whether this prediction was mediated by social support and connectedness to others...
March 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29670397/effectiveness-of-fixed-site-high-frequency-transcutaneous-electrical-nerve-stimulation-in-chronic-pain-a-large-scale-observational-study
#20
Xuan Kong, Shai N Gozani
Objective: The objective of this study was to assess the effectiveness of fixed-site high-frequency transcutaneous electrical nerve stimulation (FS-TENS) in a real-world chronic pain sample. Background: There is a need for nonpharmacological treatment options for chronic pain. FS-TENS improved multisite chronic pain in a previous interventional study. Large observational studies are needed to further characterize its effectiveness. Methods: This retrospective observational cohort study examined changes in chronic pain measures following 60 days of FS-TENS use...
2018: Journal of Pain Research
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