keyword
https://read.qxmd.com/read/38547147/driving-factors-and-grouping-paths-of-rural-sports-development-in-china-a-qualitative-comparative-analysis-based-on-fuzzy-sets
#21
JOURNAL ARTICLE
Duan Yu, Hongwei Fan, Ning Zhang
The development of rural sports depends on many factors, but the complex causal relationship between various factors and the level of rural sports development is not clear. Using data envelopment analysis (DEA) and fuzzy set qualitative comparative analysis (fsQCA), this study aims to examine the driving role of various factors on rural sports development and construct various grouping paths to improve the level of rural sports development in China. The results shows that the area of fitness venues and social capital participation are sufficient conditions for the development of rural sports in China...
2024: PloS One
https://read.qxmd.com/read/38547125/protocol-for-predicting-multivariate-change-of-brain-patterns-using-model-informed-fmri-activations
#22
JOURNAL ARTICLE
Leon Möhring, Jan Gläscher
Investigating the spatially distributed information contained in fMRI data is essential for understanding brain functions. Here, we present a protocol to dynamically predict short-term changes in neural patterns using trial-by-trial blood-oxygen-level-dependent (BOLD) activity of a seed region. We describe steps for setting fMRI data acquisition parameters and quantification of changes in multivariate patterns. We then detail procedures for defining seed regions and identifying brain areas in which changes in multivariate patterns can be predicted by BOLD activity of the seed region...
March 26, 2024: STAR protocols
https://read.qxmd.com/read/38547084/raising-awareness-of-uncertain-choices-in-empirical-data-analysis-a-teaching-concept-toward-replicable-research-practices
#23
JOURNAL ARTICLE
Maximilian M Mandl, Sabine Hoffmann, Sebastian Bieringer, Anna E Jacob, Marie Kraft, Simon Lemster, Anne-Laure Boulesteix
Throughout their education and when reading the scientific literature, students may get the impression that there is a unique and correct analysis strategy for every data analysis task and that this analysis strategy will always yield a significant and noteworthy result. This expectation conflicts with a growing realization that there is a multiplicity of possible analysis strategies in empirical research, which will lead to overoptimism and nonreplicable research findings if it is combined with result-dependent selective reporting...
March 2024: PLoS Computational Biology
https://read.qxmd.com/read/38547061/the-%C3%AE-2-adrenergic-receptor-associates-with-cxcr4-multimers-in-human-cancer-cells
#24
JOURNAL ARTICLE
Junyi Liang, Mohamed Seghiri, Pradeep Kumar Singh, Hyeon Gyu Seo, Ji Yeong Lee, Yoonjung Jo, Yong Bhum Song, Chulo Park, Piotr Zalicki, Jae-Yeon Jeong, Won-Ki Huh, Niña G Caculitan, Adam W Smith
While the existence and functional role of class C G-protein-coupled receptors (GPCR) dimers is well established, there is still a lack of consensus regarding class A and B GPCR multimerization. This lack of consensus is largely due to the inherent challenges of demonstrating the presence of multimeric receptor complexes in a physiologically relevant cellular context. The C-X-C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer therapy. Here, we investigated the potential of CXCR4 to form multimeric complexes with other GPCRs and characterized the relative size of the complexes in a live-cell environment...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38547058/nsun5-tet2-directed-chromatin-associated-rna-modification-of-5-methylcytosine-to-5-hydroxymethylcytosine-governs-glioma-immune-evasion
#25
JOURNAL ARTICLE
Ruixin Wu, Chunming Sun, Xi Chen, Runyue Yang, Yuxuan Luan, Xiang Zhao, Panpan Yu, Rongkui Luo, Yingyong Hou, Ruotong Tian, Shasha Bian, Yuli Li, Yinghua Dong, Qian Liu, Weiwei Dai, Zhuoyang Fan, Rucheng Yan, Binyang Pan, Siheng Feng, Jing Wu, Fangzhen Chen, Changle Yang, Hanlin Wang, Haochen Dai, Minfeng Shu
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains unclear, as does the contribution of m5C-modified RNA to the glioma immune microenvironment. In this study, we demonstrate that the canonical 28SrRNA methyltransferase NSUN5 down-regulates β-catenin by promoting the degradation of its mRNA, leading to enhanced phagocytosis of tumor-associated macrophages (TAMs)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38547039/combined-wrist-extensor-tenodesis-and-tendon-transfers-for-severe-spastic-flexed-wrist-deformity-surgical-technique-and-case-series
#26
JOURNAL ARTICLE
Paula A Pino, Christopher S Crowe, Kitty Y Wu, Peter C Rhee
Spastic wrist flexion deformities both limit the functional use of the hand for grasp and pinch producing a stigmatizing appearance. Tendon transfers and total wrist arthrodesis are treatment options for this condition depending on the patient's characteristics, the latter the most commonly used in patients with severe wrist flexion deformities. Tendon transfers alone in this scenario have the tendency for recurrent deformity due to tenorrhaphy failure or soft tissue creep and resultant loss of tension. Total wrist arthrodesis is a more invasive procedure, which can have hardware or fusion problems and that is irreversible...
March 28, 2024: Techniques in Hand & Upper Extremity Surgery
https://read.qxmd.com/read/38546995/impact-of-background-foreground-and-manipulated-object-rendering-on-egocentric-depth-perception-in-virtual-and-augmented-indoor-environments
#27
JOURNAL ARTICLE
Matthew McQuaigue, Kalpathi Subramanian, Paula Goolkasian, Zachary Wartell
This research investigated how the similarity of the rendering parameters of background and foreground objects affected egocentric depth perception in indoor virtual and augmented environments. We refer to the similarity of the rendering parameters as visual 'congruence'. Study participants manipulated the depth of a sphere to match the depth of a designated target peg. In the first experiment, the sphere and peg were both virtual, while in the second experiment, the sphere is virtual and the peg is real. In both experiments, depth perception accuracy was found to depend on the levels of realism and congruence between the sphere, pegs, and background...
March 28, 2024: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/38546988/multicenter-hierarchical-federated-learning-with-fault-tolerance-mechanisms-for-resilient-edge-computing-networks
#28
JOURNAL ARTICLE
Xiaohong Chen, Guanying Xu, Xuesong Xu, Haichong Jiang, Zhiping Tian, Tao Ma
In the realm of federated learning (FL), the conventional dual-layered architecture, comprising a central parameter server and peripheral devices, often encounters challenges due to its significant reliance on the central server for communication and security. This dependence becomes particularly problematic in scenarios involving potential malfunctions of devices and servers. While existing device-edge-cloud hierarchical FL (HFL) models alleviate some dependence on central servers and reduce communication overheads, they primarily focus on load balancing within edge computing networks and fall short of achieving complete decentralization and edge-centric model aggregation...
March 28, 2024: IEEE Transactions on Neural Networks and Learning Systems
https://read.qxmd.com/read/38546986/size-tunable-manganese-doped-spheroidal-cspbcl-3-quantum-dots
#29
JOURNAL ARTICLE
Patrick von Schwerin, Markus Döblinger, Tushar Debnath, Jochen Feldmann, Quinten A Akkerman
Manganese doping has been demonstrated as a versatile tool to tune the emission of CsPbCl3 nanocrystals (NCs). Although this has been demonstrated in nanocubes and nanoplatelets, strategies for doping Mn2+ in size-tunable, excitonic CsPbCl3 quantum dots (QDs) remain absent. In this work, we demonstrate the synthesis of size-tunable spheroidal CsPbCl3 :Mn2+ QDs, which can be obtained by a water-hexane interfacial combined anion and cation exchange strategy starting from CsPbBr3 QDs. Interestingly, the QDs exhibit a fast 0...
March 28, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38546978/role-of-kcnk3-dysfunction-in-dasatinib-associated-pah-and-endothelial-cell-dysfunction
#30
JOURNAL ARTICLE
Hélène Le Ribeuz, Anaïs Saint-Martin Willer, Benoit Chevalier, Maria Sancho, Bastien Masson, Mélanie Eyries, Vincent Jung, Ida Chiara Guerrera, Mary Dutheil, Kristelle El Jekmek, Loann Laubry, Gilles Carpentier, Francisco Perez-Vizcaino, Ly Tu, Christophe Guignabert, Marie-Camille Chaumais, Christine Péchoux, Marc Humbert, Alexandre Hinzpeter, Olaf Mercier, Véronique Capuano, David Montani, Fabrice Antigny
Pulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function...
March 28, 2024: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38546903/novel-multiplexed-high-throughput-screening-of-selective-inhibitors-for-drug-metabolizing-enzymes-using-human-hepatocytes
#31
JOURNAL ARTICLE
Jianhua Liu, Daria Vernikovskaya, Gary Bora, Anthony Carlo, Woodrow Burchett, Samantha Jordan, Lloyd Wei Tat Tang, Joy Yang, Ye Che, George Chang, Matthew D Troutman, Li Di
Selective chemical inhibitors are critical for reaction phenotyping to identify drug-metabolizing enzymes that are involved in the elimination of drug candidates. Although relatively selective inhibitors are available for the major cytochrome P450 enzymes (CYP), they are quite limited for the less common CYPs and non-CYPs. To address this gap, we developed a multiplexed high throughput screening (HTS) assay using 20 substrate reactions of multiple enzymes to simultaneously monitor the inhibition of enzymes in a 384-well format...
March 28, 2024: AAPS Journal
https://read.qxmd.com/read/38546899/micromorphology-and-silicon-of-the-leaf-epidermis-in-the-psammophyte-alyssum-desertorum-are-sensitive-to-soil-flooding
#32
JOURNAL ARTICLE
Olena Nedukha
The ultrastructure of the leaf epidermis and the localization and content of silicon in epidermal cells of the psammophyte Alyssum desertorum Stapf (Brassicaceae) were investigated using electron microscopy and laser confocal microscopy. The study aimed to examine the effect of flooding on the epidermal structure of the leaves, study the presence, localization, and content of silicon in the epidermal cells and determine whether changes in soil moisture affect the silicon content in the leaf epidermis. Silicon inclusions were observed in trichomes and typical epidermal cells on both leaf surfaces, with varying content depending on the cell type, leaf surface, and conditions growth...
March 28, 2024: Protoplasma
https://read.qxmd.com/read/38546894/a-novel-imprinted-locus-on-bovine-chromosome-18-homologous-with-human-chromosome-16q24-1
#33
JOURNAL ARTICLE
Haonan Huo, Cui Zhang, Kun Wang, Siwei Wang, Weina Chen, Yinjiao Zhang, Wenli Yu, Shujing Li, Shijie Li
Genomic imprinting is an epigenetic regulation mechanism in mammals resulting in the parentally dependent monoallelic expression of genes. Imprinting disorders in humans are associated with several congenital syndromes and cancers and remain the focus of many medical studies. Cattle is a better model organism for investigating human embryo development than mice. Imprinted genes usually cluster on chromosomes and are regulated by different methylation regions (DMRs) located in imprinting control regions that control gene expression in cis...
March 28, 2024: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/38546892/influence-of-degree-of-substitution-on-the-hydroxypropyl-%C3%AE-cyclodextrin-complexation-with-rifampicin-in-water-solution-a-molecular-simulation
#34
JOURNAL ARTICLE
Elena Alvira
CONTEXT: Hydroxypropyl-β-cyclodextrin (HPβCD) is one of the derivatized cyclodextrins most widely used as an excipient in the pharmaceutical industry, for its capacity to improve certain drugs properties. Different configurations of HPβCD are possible depending on the number and location of the 2-hydroxypropyl groups substituted on the glucose rings. Rifampicin has become the most commonly clinically used antibiotic against tuberculosis in recent years, despite its low solubility and variable bioavailability...
March 28, 2024: Journal of Molecular Modeling
https://read.qxmd.com/read/38546891/an-emerging-role-for-enhancer-rnas-in-brain-disorders
#35
REVIEW
Ankit Patel, Ashutosh Dharap
Noncoding DNA undergoes widespread context-dependent transcription to produce noncoding RNAs. In recent decades, tremendous advances in genomics and transcriptomics have revealed important regulatory roles for noncoding DNA elements and the RNAs that they produce. Enhancers are one such element that are well-established drivers of gene expression changes in response to a variety of factors such as external stimuli, cellular responses, developmental cues, and disease states. They are known to act at long distances, interact with multiple target gene loci simultaneously, synergize with other enhancers, and associate with dynamic chromatin architectures to form a complex regulatory network...
March 28, 2024: Neuromolecular Medicine
https://read.qxmd.com/read/38546877/melittin-phospholipase-a-2-synergism-is-mediated-by-liquid-liquid-miscibility-phase-transition-in-giant-unilamellar-vesicles
#36
JOURNAL ARTICLE
Sein Min, Cyrus Picou, Hye Jin Jeong, Adam Bower, Keunhong Jeong, Jean K Chung
The primary constituents of honeybee venom, melittin and phospholipase A2 (PLA2 ), display toxin synergism in which the PLA2 activity is significantly enhanced by the presence of melittin. It has been shown previously that this is accomplished by the disruption in lipid packing, which allows PLA2 to become processive on the membrane surface. In this work, we show that melittin is capable of driving miscibility phase transition in giant unilamellar vesicles (GUVs) and that it raises the miscibility transition temperature ( T misc ) in a concentration-dependent manner...
March 28, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38546868/changes-in-stress-urinary-incontinence-symptoms-after-pelvic-organ-prolapse-surgery-a-nationwide-cohort-study-finpop
#37
JOURNAL ARTICLE
Päivi K Karjalainen, Anna-Maija Tolppanen, Olga Wihersaari, Kari Nieminen, Nina K Mattsson, Jyrki T Jalkanen
INTRODUCTION AND HYPOTHESIS: Various strategies are employed to manage stress urinary incontinence (SUI) during pelvic organ prolapse (POP) surgery. This study was aimed at facilitating shared decision-making by evaluating SUI symptom changes, staged SUI procedures, and their prognostic factors following POP surgery without concomitant SUI intervention. METHODS: We analyzed 2,677 POP surgeries from a population-based observational cohort, excluding patients with prior SUI surgery...
March 28, 2024: International Urogynecology Journal
https://read.qxmd.com/read/38546860/cat-bite-injuries-to-the-hand-and-forearm-the-impact-of-antibiotic-treatment-on-microbiological-findings-and-clinical-outcome
#38
JOURNAL ARTICLE
Sebastian Wangler, Miriam Elias, Linus Schoepke, Dominique N Merky, Rahel Meier, Esther Vögelin
INTRODUCTION: Patients and physicians often underestimate cat bite injuries. The deep and narrow wound seals quickly and provides an environment for the inoculated saliva and bacteria. Interestingly, the literature reports no bacterial growth in the microbiological workup of wound swaps in up to 43%. The time between bite injury and the first clinical presentation, the start of antibiotic treatment and surgical debridement might affect these findings. Therefore, the current project examines if (1) these factors impact the outcome of microbiological results following cat bite injuries and (2) the detection of bacterial growth leads to higher complication rates, longer hospital stays, longer total treatment time, or higher total treatment costs...
March 28, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38546850/salvage-transoral-robotic-surgery-in-recurrent-oropharyngeal-carcinoma-a-single-center-retrospective-study
#39
JOURNAL ARTICLE
Mohssen Ansarin, Giacomo Pietrobon, Marta Tagliabue, Chiara Mossinelli, Francesca Ruju, Fausto Maffini, Maria Cossu Rocca, Daniela Alterio, Christian Simon, Stefano Filippo Zorzi
PURPOSE: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to present oncological and functional outcomes of a monocentric experience in salvage transoral robotic surgery. METHODS: We performed a single-center retrospective analysis of patients submitted to transoral robotic salvage surgery with or without neck dissection for cT1-3 rOPSCC...
March 28, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38546835/ochratoxin-a-induces-hepatic-and-renal-toxicity-in-mice-through-increased-oxidative-stress-mitochondrial-damage-and-multiple-cell-death-mechanisms
#40
JOURNAL ARTICLE
Youlim Son, Hyun Jung Lee, Dojin Ryu, Jae-Ryong Kim, Hwa-Young Kim
Ochratoxin A (OTA) is a widespread food toxin produced by Aspergillus ochraceus and other molds. In this study, we developed and established acute OTA toxicity conditions in mice, which received daily oral doses of OTA between 0.5 up to 8 mg/kg body weight up to 7 days and were subjected to histological and biochemical analysis to characterize renal and hepatic damage. Oral administration of OTA for 7 days resulted in loss of body weight in a dose-dependent manner and increased the levels of serum biomarkers of hepatic and renal damage...
March 28, 2024: Archives of Toxicology
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