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Continuous glucose monitoring

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https://www.readbyqxmd.com/read/29774672/glucose-sensitive-silicone-hydrogel-contact-lens-toward-tear-glucose-monitoring
#1
Ramachandram Badugu, Edward Albert Reece, Joseph R Lakowicz
Accurate and reliable monitoring of blood glucose is needed for the treatment of diabetes, which has many challenges, including lack of patient compliance. Measuring tear glucose is an alternative to traditional finger-stick tests used to track blood sugar levels, but glucose sensing using tears has yet to be achieved. We report a methodology for possible tear glucose monitoring using glucose-sensitive silicone hydrogel (SiHG) contact lenses, the primary type of lenses available in today's market. Initially, we assessed the interpenetrating polymer network, with nearly pure silicone and water regions, existing in the SiHGs using a polarity-sensitive probe Prodan...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29772654/consistency-of-continuous-ambulatory-interstitial-glucose-monitoring-sensors
#2
Pei T Wu, David E Segovia, Cathy C Lee, Kim-Lien Nguyen
AIMS: The abdominal region is the most common location for continuous glucose monitor (CGM) sensor insertion. However, a paucity of post-marketing data is available to demonstrate intra-individual consistency of CGM readings at different abdominal insertion sites. METHODS: Healthy adults (fasting glucose (FG) < 5.5 mmol/L; BMI < 30 kg/m²) were recruited and a CGM sensor was placed on each side of the abdomen. Postprandial and continuous 48-h interstitial glucose levels were analyzed...
May 16, 2018: Biosensors
https://www.readbyqxmd.com/read/29770541/effect-of-short-term-treatment-with-sitagliptin-or-glibenclamide-on-daily-glucose-fluctuation-in-drug-na%C3%A3-ve-japanese-patients-with-type-2-diabetes-mellitus
#3
Ryo Suzuki, Jun-Ichi Eiki, Takashi Moritoyo, Kenichi Furihata, Akira Wakana, Yukari Ohta, Shigeru Tokita, Takashi Kadowaki
AIMS: To compare the effect of a dipeptidyl peptidase-4 inhibitor (DPP4-i) and a sulfonylurea (SU) on daily glucose fluctuation in drug-naïve Japanese patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Fifty-three drug-naïve Japanese patients with T2DM (HbA1c of 7.0% to 9.0% and fasting plasma glucose of 6.1 mmol/L or higher) were randomly assigned to either sitagliptin 50 mg q.d. or glibenclamide 2.5 mg per day (given in divided doses) in a 1:1 ratio...
May 17, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29769806/paediatric-type-1-diabetes-2018-clinical-and-research-insights
#4
Stephen J Zborovski, Farid H Mahmud
The management of children and adolescents with type 1 diabetes continues to progress as clinical and technological innovations enter into practice. Variability in glucose readings can present a significant challenge for care providers, patients and families alike and recent research demonstrates that insulin selection and site-related lipohypertrophy can significantly influence blood glucose levels. New technology aims to improve both glycemic control and quality of life. New insulin analogues have been developed and insulin pumps and continuous glucose monitoring systems continue to evolve toward a fully closed-loop system...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29767510/non-enzymatic-wearable-sensor-for-electrochemical-analysis-of-perspiration-glucose
#5
Xiaofei Zhu, Yinhui Ju, Jian Chen, Deye Liu, Hong Liu
We report a non-enzymatic wearable sensor for electrochemical analysis of perspiration glucose. Multi-potential steps are applied on a Au electrode, including a high negative pretreatment potential step for proton reduction which produc-es a localized alkaline condition, a moderate potential step for electrocatalytic oxidation of glucose under the alkaline condi-tion, and a positive potential step to clean and reactivate the electrode surface for the next detection. Fluorocarbon-based materials were coated on the Au electrode for improving the selectivity and robustness of the sensor...
May 16, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29764813/real-time-continuous-glucose-monitoring-improves-glycaemic-variability-and-neonatal-outcomes-in-pregnant-women-with-type-1-diabetes
#6
REVIEW
Sally K Abell, Sophia Zoungas
No abstract text is available yet for this article.
May 15, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29763267/top-20-research-studies-of-2017-for-primary-care-physicians
#7
Mark H Ebell, Roland Grad
Based on systematic surveillance of more than 110 medical journals, 247 studies met criteria as POEMs (patient-oriented evidence that matters) in 2017. Members of the Canadian Medical Association identified 20 of these POEMs as most relevant to practice. This article reviews the clinical questions and bottom-line answers from these studies. Blood pressure should be measured after a period of rest, using a bare arm, and orthostatic blood pressure is more predictive when measured after one minute of standing rather than three minutes...
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29761993/-design-and-implementation-of-real-time-continuous-glucose-monitoring-instrument
#8
Yonghong Huang, Hongying Liu, Senfu Tian, Ziru Jia, Zi Wang, Xitian Pi
Real-time continuous glucose monitoring can help diabetics to control blood sugar levels within the normal range. However, in the process of practical monitoring, the output of real-time continuous glucose monitoring system is susceptible to glucose sensor and environment noise, which will influence the measurement accuracy of the system. Aiming at this problem, a dual-calibration algorithm for the moving-window double-layer filtering algorithm combined with real-time self-compensation calibration algorithm is proposed in this paper, which can realize the signal drift compensation for current data...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29761917/cationic-europium-complexes-for-visualizing-fluctuations-in-mitochondrial-atp-levels-in-living-cells
#9
Romain Mailhot, Thomas Traviss-Pollard, Robert Pal, Stephen Jonathan Butler
The ability to study cellular metabolism and enzymatic processes involving adenosine triphosphate (ATP) is impeded by the lack of imaging probes capable of signaling the concentration of intracellular ATP rapidly, with high sensitivity. We report the first example of a luminescent lanthanide complex capable of visualizing changes in the concentration of ATP in the mitochondria of living cells. Four cationic europium(III) complexes [Eu.1-4]+ have been synthesized and their binding affinities towards nucleoside polyphosphate anions examined at physiological pH...
May 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29753624/a-critical-review-and-analysis-of-ethical-issues-associated-with-the-artificial-pancreas
#10
REVIEW
A Quintal, V Messier, R Rabasa-Lhoret, E Racine
The artificial pancreas combines a hormone infusion pump with a continuous glucose ontinuous glucose monitoring, supported by a dosing algorithm currently installed on the pump. It allows for dynamic infusions of insulin (and possibly other hormones such as glucagon) tailored to patient needs. For patients with type 1 diabetes the artificial pancreas has been shown to prevent more effectively hypoglycaemic events and hyperglycaemia than insulin pump therapy and has the potential to simplify care. However, the potential ethical issues associated with the upcoming integration of the artificial pancreas into clinical practice have not yet been discussed...
April 25, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29753586/cost-effectiveness-of-sensor-augmented-pump-therapy-in-two-different-patient-populations-with-type-1-diabetes-in-italy
#11
A Nicolucci, M C Rossi, D D'Ostilio, A Delbaere, S de Portu, S Roze
BACKGROUND AND AIMS: Sensor-augmented pump therapy (SAP) combines real time continuous glucose monitoring (CGM) with Continuous Subcutaneous Insulin Infusion (CSII) and provides additional benefits beyond those provided by CSII alone. SAP with automated insulin suspension provides early warning of the onset of hyperglycemia and hypoglycemia and has the functionality to suspend insulin delivery if sensor glucose levels are predicted to fall below a predefined threshold. Aim of this study was to assess the cost-effectiveness of SAP with automated insulin suspension versus CSII alone in type 1 diabetes...
April 5, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29750797/critical-depth-raman-spectroscopy-enables-home-use-non-invasive-glucose-monitoring
#12
Signe M Lundsgaard-Nielsen, Anders Pors, Stefan O Banke, Jan E Henriksen, Dietrich K Hepp, Anders Weber
One of the most ambitious endeavors in the field of diabetes technology is non-invasive glucose sensing. In the past decades, a number of different technologies have been assessed, but none of these have found its entry into general clinical use. We report on the development of a table-top confocal Raman spectrometer that was used in the home of patients with diabetes and operated for extended periods of time unsupervised and without recalibration. The system is based on measurement of glucose levels at a 'critical depth' in the skin, specifically in the interstitial fluid located below the stratum corneum but above the underlying adipose tissue layer...
2018: PloS One
https://www.readbyqxmd.com/read/29750502/wearable-contact-lens-biosensors-for-continuous-glucose-monitoring-using-smartphones
#13
Mohamed Elsherif, Muhammad Umair Hassan, Ali K Yetisen, Haider Butt
Low-cost, robust, and reusable continuous glucose monitoring systems that can provide quantitative measurements at point-of-care settings is an unmet medical need. Optical glucose sensors require complex and time-consuming fabrication process and their readouts are not practical for quantitative analyses. Here, a wearable contact lens optical sensor was created for the continuous quantification of glucose at physiological conditions, simplifying the fabrication process and facilitating smartphone readouts. A photonic microstructure having a periodicity of 1...
May 11, 2018: ACS Nano
https://www.readbyqxmd.com/read/29749032/comparison-between-preprandial-versus-postprandial-insulin-aspart-administration-in-patients-with-type-1-diabetes-benefiting-from-insulin-pump-and-real-time-continuous-glucose-monitoring
#14
Philippe Thuillier, Emmanuel Sonnet, Zarrin Alavi, Nathalie Roudaut, Emmanuel Nowak, Angélina Dion, Véronique Kerlan
BACKGROUND: The objective was to compare glycemic control between pre- and post-prandial bolus administration (15min before (PRE) or immediately after the meal (POST)) in patients with type 1 diabetes using insulin pump and real time continuous glucose monitoring (RT-CGM). METHODS: Between September 2015 and February 2016, a single-centre, open randomized, two-way crossover study of patients on bolus insulin aspart administration was conducted during two 14-days periods and according to two administration regimen schedules(...
May 10, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29746878/effect-of-short-bouts-of-high-intensity-activity-on-glucose-among-adults-with-prediabetes-a-pilot-randomized-crossover-study
#15
Jennifer L Gay, David M Buchner, Melissa L Erickson, Adolphia Lauture
AIM: Few data exist on the effects of vigorous-intensity activity on blood glucose. The study aim was to determine the effects of 2-min and 4-min bouts of vigorous-intensity stair climbing on glucose levels. METHODS: Nine overweight/obese adults with prediabetes (40-64 years, HbA1C 5.7%-6.4%) participated in a randomized cross-over design with three conditions on consecutive days: control; 2-min bouts of stair climbing once per hour for 8 hours; and 4-min bouts of stair climbing once every 2 hours for 8 hours, with the two activity days randomized in order...
May 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29744820/artificial-pancreas-as-an-effective-and-safe-alternative-in-patients-with-type-1-diabetes-mellitus-a-systematic-review-and-meta-analysis
#16
Xia Dai, Zu-Chun Luo, Lu Zhai, Wen-Piao Zhao, Feng Huang
INTRODUCTION: Insulin injection is the main treatment in patients with type 1 diabetes mellitus (T1DM). Even though continuous glucose monitoring has significantly improved the conditions of these patients, limitations still exist. To further enhance glucose control in patients with T1DM, an artificial pancreas has been developed. We aimed to systematically compare artificial pancreas with its control group during a 24-h basis in patients with T1DM. METHODS: Electronic databases were carefully searched for English publications comparing artificial pancreas with its control group...
May 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29744819/comparison-of-glycemic-variability-in-chinese-t2dm-patients-treated-with-exenatide-or-insulin-glargine-a-randomized-controlled-trial
#17
Ting-Ting Yin, Yan Bi, Ping Li, Shan-Mei Shen, Xiao-Lu Xiong, Li-Jun Gao, Can Jiang, Yan Wang, Wen-Huan Feng, Da-Long Zhu
INTRODUCTION: Increasing the frequency of blood glucose monitoring aids the evaluation of glycemic variability and blood glucose control by antidiabetic drugs. It remains unclear, however, whether GLP-1 receptor agonists or basal insulin has a better effect on glycemic variability in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled by metformin. We used a continuous glucose monitoring system (CGMS) to compare patients on a GLP-1 receptor agonist with patients on basal insulin in terms of glycemic variability...
May 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29743073/parallel-substrate-supply-and-ph-stabilization-for-optimal-screening-of-e-coli-with-the-membrane-based-fed-batch-shake-flask
#18
P Philip, D Kern, J Goldmanns, F Seiler, A Schulte, T Habicher, J Büchs
BACKGROUND: Screening in the fed-batch operation mode is essential for biological cultivations facing challenges as oxygen limitation, osmotic inhibition, catabolite repression, substrate inhibition or overflow metabolism. As a screening tool on shake flask level, the membrane-based fed-batch shake flask was developed. While a controlled supply of a substrate was realized with the in-built membrane tip, the possibilities for replenishing nutrients and stabilizing pH values was not yet exploited...
May 9, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29737587/the-glycaemic-benefits-of-a-very-low-carbohydrate-ketogenic-diet-in-adults-with-type-1-diabetes-mellitus-may-be-opposed-by-increased-hypoglycaemia-risk-and-dyslipidaemia
#19
Z Z X Leow, K J Guelfi, E A Davis, T W Jones, P A Fournier
AIMS: To investigate whether very-low-carbohydrate high-fat diets, typical of ketogenic diets, can improve glycaemic control without causing any ill health effects in adults with Type 1 diabetes. METHODS: In this observational study, 11 adults with Type 1 diabetes (seven men, four women, mean ± sd age 36.1± 6.8 years, mean ± sd duration of diabetes 12.8 ± 10.3 years), who followed a ketogenic diet (< 55 g carbohydrate per day) for a mean ± sd of 2.6 ± 3...
May 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29737202/health-care-costs-hospital-admissions-and-glycemic-control-using-a-standalone-real-time-continuous-glucose-monitoring-system-in-commercially-insured-patients-with-type-1-diabetes
#20
Max Gill, Cyrus Zhu, Mona Shah, Harmeet Chhabra
BACKGROUND: Studies comparing standalone real-time continuous glucose monitoring (rtCGM) to self-monitoring of blood glucose (SMBG) in patients with type 1 diabetes mellitus (T1DM) have found that rtCGM is associated with lower glycated hemoglobin (A1C) levels, yet does not increase the risk of severe hypoglycemia. However, little is known about the relationship between rtCGM and health care costs and utilization. The objective of this study was to compare health care spending, hospital admissions, and A1C levels of patients using rtCGM to that of patients not using rtCGM...
May 1, 2018: Journal of Diabetes Science and Technology
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