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Continuous glucose monitoring

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https://www.readbyqxmd.com/read/28213374/diurnal-differences-in-risk-of-cardiac-arrhythmias-during-spontaneous-hypoglycemia-in-young-people-with-type-1-diabetes
#1
Peter Novodvorsky, Alan Bernjak, Elaine Chow, Ahmed Iqbal, Lianne Sellors, Scott Williams, Robert A Fawdry, Bhavin Parekh, Richard M Jacques, Jefferson L B Marques, Paul J Sheridan, Simon R Heller
OBJECTIVE: Hypoglycemia may exert proarrhythmogenic effects on the heart via sympathoadrenal stimulation and hypokalemia. Hypoglycemia-induced cardiac dysrhythmias are linked to the "dead-in-bed syndrome," a rare, but devastating, condition. We examined the effect of nocturnal and daytime clinical hypoglycemia on electrocardiogram (ECG) in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS: Thirty-seven individuals with type 1 diabetes underwent 96 h of simultaneous ambulatory ECG and blinded continuous interstitial glucose monitoring (CGM) while symptomatic hypoglycemia was recorded...
February 17, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28209654/replace-bg-a-randomized-trial-comparing-continuous-glucose-monitoring-with-and-without-routine-blood-glucose-monitoring-in-well-controlled-adults-with-type-1-diabetes
#2
Grazia Aleppo, Katrina J Ruedy, Tonya D Riddlesworth, Davida F Kruger, Anne L Peters, Irl Hirsch, Richard M Bergenstal, Elena Toschi, Andrew J Ahmann, Viral N Shah, Michael R Rickels, Bruce W Bode, Athena Philis-Tsimikas, Rodica Pop-Busui, Henry Rodriguez, Emily Eyth, Anuj Bhargava, Craig Kollman, Roy W Beck
OBJECTIVE: To determine whether the use of continuous glucose monitoring (CGM) without confirmatory blood glucose monitoring (BGM) measurements is as safe and effective as using CGM adjunctive to BGM in well-controlled adults with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: A randomized noninferiority clinical trial was conducted at 14 sites in the T1D Exchange Clinic Network. Participants were ≥18 years of age (mean 44 ± 14 years), had T1D for ≥1 year (mean duration 24 ± 12 years), used an insulin pump, and had an HbA1c ≤9...
February 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28205324/evaluation-of-subcutaneous-glucose-monitoring-systems-under-routine-environmental-conditions-in-patients-with-type-1-diabetes
#3
Felix Aberer, Martin Hajnsek, Markus Rumpler, Sabine Zenz, Petra Baumann, Hesham Elsayed, Adelheid Puffing, Gerlies Treiber, Thomas R Pieber, Harald Sourij, Julia K Mader
: Continuous and flash glucose monitoring (GM) systems have been established in diabetes care. We compared sensor performance of three commercially available GM systems. 12 patients with type 1 diabetes were included in a single-centre, open-label study where sensor performance of Abbott FreeStyle libre (Abbott), Dexcom G4 Platinum (Dexcom) and Medtronic MiniMed 640G (Medtronic) over 12 hours was compared during mimicked real-life conditions (meals, exercise, hypo- and hyperglycaemia)...
February 16, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28195034/treatment-of-spinocerebellar-ataxia-with-mesenchymal-stem-cells-a-phase-i-iia-clinical-study
#4
Yun-An Tsai, Ren-Shyan Liu, Jiing-Feng Lirng, Bang-Hung Yang, Chin-Hao Chang, YiChen Wang, Yu-Shan Wu, Jennifer Hui-Chun Ho, Oscar K Lee, Bing-Wen Soong
Ataxia is one of the most devastating symptoms of many neurodegenerative disorders. As of today, there isn’tany effective treatment to retard its progression. Mesenchymal stem cells (MSCs) have shown promise in treating neurodegenerative diseases. We hereby report the results of a phase I/IIa clinical study conducted in Taiwan to primarily evaluate the safety, tolerability and, secondarily, the possible efficacy of intravenous administration of allogeneic adipose tissuederived MSCs from healthy donors...
February 14, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28192020/continuous-glucose-monitoring-in-2016
#5
Bruce W Bode, Tadej Battelino
No abstract text is available yet for this article.
February 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28174144/eating-and-rumination-behaviour-in-cows-with-traumatic-reticuloperitonitis
#6
U Braun, T Tschoner, M Hässig, K Nuss
Eating and rumination behaviour in 22 cows with traumatic reticuloperitonitis was recorded after the start of treatment. Based on the results of clinical, ultrasonographic and radiographic examinations, the cows were divided into two groups: Group A consisted of 12 cows without an intramural or perforating foreign body and group B had 10 cows with an intramural or perforating foreign body. Cows of group A received amoxicillin, flunixin meglumine and a NaCl-glucose infusion, and cows of group B received the same treatment accompanied by foreign body removal via ruminotomy...
February 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28169570/effectiveness-of-interventions-for-promoting-objectively-measured-physical-activity-of-adults-with-type-2-diabetes-a-systematic-review
#7
Shaima Alothman, Abdalghani Yahya, Jason Rucker, Patricia M Kluding
BACKGROUND: Many people with type 2 diabetes (T2D) are sedentary despite strong recommendations of regular physical activity (PA). Objective measures of PA provide accurate reflection of daily PA level. The purpose of this review was to analyze studies used pedometers or accelerometers to determine the outcome of interventions promoted daily PA in people with T2D. METHODS: An electronic literature search was conducted using the PubMed and CINAHL databases (2000 - 2016), with search terms: sedentary, diabetes, pedometer, physical activity, and accelerometer...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28168194/decolourisation-capabilities-of-ligninolytic-enzymes-produced-by-marasmius-cladophyllus-umas-ms8-on-remazol-brilliant-blue-r-and-other-azo-dyes
#8
Ngieng Ngui Sing, Ahmad Husaini, Azham Zulkharnain, Hairul Azman Roslan
Marasmius cladophyllus was examined for its ability to degradatively decolourise the recalcitrant dye Remazol Brilliant Blue R (RBBR) and screened for the production of ligninolytic enzymes using specific substrates. Monitoring dye decolourisation by the decrease in absorbance ratio of A592/A500 shows that the decolourisation of RBBR dye was associated with the dye degradation. Marasmius cladophyllus produces laccase and lignin peroxidase in glucose minimal liquid medium containing RBBR. Both enzyme activities were increased, with laccase activity recorded 70 times higher reaching up to 390 U L(-1) on day 12...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28163257/the-relation-of-glycaemic-variability-with-inflammatory-markers-in-obese-children-with-insulin-resistance-and-metabolic-syndrome
#9
Abdurrahman Kaya, Cemil Koçyiğit, Gönül Çatlı, Elif Büşra Özkan, Bumin Nuri Dündar
OBJECTIVE: To investigate the relationship between glycaemic variability and inflammatory parameters in obese children with insulin resistance and to elucidate their effects on the development of metabolic syndrome. METHODS: Fifty obese adolescents with insulin resistance were included in the study. All patients underwent anthropometric measurements, body fat analysis and continuous glucose monitoring system (CGMS) for 24 hours. Serum lipids, adiponectin and interleukin-6 (IL-6) levels were measured...
February 6, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28161977/achieving-effective-glycaemic-control-using-an-insulin-micro-pump
#10
Peter Kelly
For those with type 1 diabetes mellitus (T1DM), a deranged blood glucose level can cause hypo/hyperglycaemic episodes and in the long term contribute to microvascular disease. Such outcomes can effect concordance with insulin management regimens and affect the patient's quality of life. A variety of insulin delivery methods are available, including continuous subcutaneous insulin infusion (CSII) via either a tethered or patch pump. Pumps have the potential to improve delivery, monitoring and adjustment of insulin regimens, thus freeing patient's time and affording more control of their disease...
February 2, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28159448/characterization-of-micro-resonator-based-on-enhanced-metal-insulator-semiconductor-capacitor-for-glucose-recognition
#11
Rajendra Dhakal, E S Kim, Yong-Hwa Jo, Sung-Soo Kim, Nam-Young Kim
We present a concept for the characterization of micro-fabricated based resonator incorporating air-bridge metal-insulator-semiconductor (MIS) capacitor to continuously monitor an individual's state of glucose levels based on frequency variation. The investigation revealed that, the micro-resonator based on MIS capacitor holds considerable promise for implementation and recognition as a glucose sensor for human serum. The discrepancy in complex permittivity as a result of enhanced capacitor was achieved for the detection and determination of random glucose concentration levels using a unique variation of capacitor that indeed results in an adequate variation of the resonance frequency...
January 31, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28154987/striving-for-control-lessons-learned-from-a-successful-international-type-1-diabetes-youth-challenge
#12
Olga Kordonouri, Andriani Vazeou, Mauro Scharf, Martina Würsig, Tadej Battelino
AIMS: To demonstrate whether young people with T1D using modern insulin treatment and CGM could successfully participate in extreme sport activity while maintaining good glycemic control. METHODS: The challenge took place in Crete/Greece over 4 days combining a long-distance trek of different levels of severity with final destination the summit of the White Mountains at 2080 m. Eleven participants (5/6 female/male, age 18.2 ± 1.3 years, T1D duration 7.9 ± 3...
February 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28150413/monitoring-of-gas-emboli-during-hysteroscopic-surgery-a-prospective-study
#13
Sheng-Qun Liu, Su-Zhen Zhao, Zhan-Wen Li, Su-Ping Lv, Yue-Qiang Liu, Yi Li
OBJECTIVES: Previous studies have demonstrated a high frequency of gas emboli during hysteroscopy, but guidelines for the prevention, early detection, and intervention of gas embolism during hysteroscopic procedures are still lacking. This study aimed to gain a clearer understanding of risk factors and specific signs and symptoms associated with gas emboli. METHODS: This prospective study enrolled 120 women scheduled for hysteroscopy using 5% glucose as distension medium...
February 2, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28147347/ph-response-and-tooth-surface-solubility-at-the-tooth-bacteria-interface
#14
Gen Mayanagi, Koei Igarashi, Jumpei Washio, Nobuhiro Takahashi
Evaluating the physiochemical processes at the tooth surface/bacteria interface is important for elucidating the etiology of dental caries. This study aimed to compare the mineral solubility and protein degradation of coronal enamel (CE) and root dentin (RD), and investigate the involvement of dissolved components in bacteria-induced pH changes using a model of tooth/bacteria interface. An experimental apparatus forming a well was made of polymethyl methacrylate, and a bovine tooth (CE or RD) specimen was fixed at the bottom of the well...
February 2, 2017: Caries Research
https://www.readbyqxmd.com/read/28144048/continuous-glucose-monitoring-a-perspective-on-its-past-present-and-future-applications-for-diabetes-management
#15
Hanna S Mariani, Brian T Layden, Grazia Aleppo
No abstract text is available yet for this article.
January 2017: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/28143733/fear-of-hypoglycemia-influence-on-glycemic-variability-and-self-management-behavior-in-young-adults-with-type-1-diabetes
#16
Pamela Martyn-Nemeth, Laurie Quinn, Sue Penckofer, Chang Park, Vanessa Hofer, Larisa Burke
PURPOSE: The purpose of this study was to examine how fear of hypoglycemia (FOH) is associated with glycemic variability (GV) and self-management behavior in young adults (aged 18-35) with type 1 diabetes (T1DM). PROCEDURES: Using a prospective repeated-measures design, in 35 young adults, within- and between-person and temporal associations of FOH, specific self-management behaviors, and GV were measured. The data were collected using questionnaires and real-time measures using daily diaries, insulin pump downloads, actigraphy, and continuous glucose monitoring...
January 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28143495/self-monitoring-of-blood-glucose-in-non-insulin-treated-type-2-diabetes-the-smbg-study-study-protocol-for-a-randomised-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Sharon Parsons, Stephen Luzio, Stephen Bain, John Harvey, Jillian McKenna, Atir Khan, Sam Rice, Alan Watkins, David R Owens
BACKGROUND: The benefit of Self-monitoring of Blood Glucose (SMBG) in people with non-insulin treated type 2 diabetes remains unclear with inconsistent evidence from randomised controlled trials fuelling the continued debate. Lack of a consistent finding has been attributed to variations in study population and design, including the SMBG intervention. There is a growing consensus that structured SMBG, whereby the person with diabetes and health care provider are educated to detect patterns of glycaemic abnormality and take appropriate action according to the blood glucose profiles, can prove beneficial in terms of lowering HbA1c and improving overall well-being...
January 26, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28134564/glucose-outcomes-with-the-in-home-use-of-a-hybrid-closed-loop-insulin-delivery-system-in-adolescents-and-adults-with-type-1-diabetes
#18
Satish K Garg, Stuart A Weinzimer, William V Tamborlane, Bruce A Buckingham, Bruce W Bode, Timothy S Bailey, Ronald L Brazg, Jacob Ilany, Robert H Slover, Stacey M Anderson, Richard M Bergenstal, Benyamin Grosman, Anirban Roy, Toni L Cordero, John Shin, Scott W Lee, Francine R Kaufman
BACKGROUND: The safety and effectiveness of the in-home use of a hybrid closed-loop (HCL) system that automatically increases, decreases, and suspends insulin delivery in response to continuous glucose monitoring were investigated. METHODS: Adolescents (n = 30, ages 14-21 years) and adults (n = 94, ages 22-75 years) with type 1 diabetes participated in a multicenter (nine sites in the United States, one site in Israel) pivotal trial. The Medtronic MiniMed(®) 670G system was used during a 2-week run-in phase without HCL control, or Auto Mode, enabled (Manual Mode) and, thereafter, with Auto Mode enabled during a 3-month study phase...
January 30, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28126247/fluid-therapy-management-in-hospitalized-patients-results-from-a-cross-sectional-study
#19
Anna Brugnolli, Federica Canzan, Anita Bevilacqua, Oliva Marognolli, Giuseppe Verlato, Silvia Vincenzi, Elisa Ambrosi
PURPOSE: Intravenous (IV) fluid therapy is widely used in hospitalized patients. It has been internationally studied in surgical patients, but little attention to date has been dedicated to medical patients within the Italian context. The aims of the present study were to describe the prevalence of fluid therapy and associated factors among Italian patients admitted to medical and surgical units, describe the methods used to manage fluid therapy, and analyze the monitoring of patients by clinical staff...
January 23, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28123707/re-evaluation-of-glycated-hemoglobin-and-glycated-albumin-with-continuous-glucose-monitoring-system-as-markers-of-glycemia-in-patients-with-liver-cirrhosis
#20
Hiroshi Isoda, Hirokazu Takahashi, Yuichiro Eguchi, Motoyasu Kojima, Kanako Inoue, Kenichiro Murayama, Yayoi Matsuda, Keizo Anzai
Liver cirrhosis (LC) is frequently accompanied by glucose intolerance. The present study was designed to determine whether glycated hemoglobin A1c (HbA1c) and glycated albumin (GA) were predictive markers of glycemia, as determined by a continuous glucose monitoring system (CGMS), in patients with LC. A total of 30 patients with LC, including 3, 19, 5, 2 and 1 with LC due to hepatitis B virus, hepatitis C virus, non-alcoholic steatohepatitis, alcohol and unknown causes, respectively, were assessed by CGMS. The average, maximum and minimum blood glucose (BG) levels were measured by CGMS, and correlated with HbA1c and GA...
January 2017: Biomedical Reports
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