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https://www.readbyqxmd.com/read/29055260/swimming-exercise-reverses-cums-induced-changes-in-depression-like-behaviors-and-hippocampal-plasticity-related-proteins
#1
Weina Liu, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi
BACKGROUND: Stress-induced failed resilience of brain plasticity can contribute to the onset and recurrence of depression. Chronic stress has been reported to open windows of epigenetic plasticity in hippocampus. However, how hippocampal plasticity underlies depression-like behaviors and how it adapts in response to stress has not been addressed. The present study aimed to investigate the signaling mechanisms of CUMS affecting hippocampal plasticity-related proteins expression and the regulation of swimming exercise in mice...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055214/effect-of-magnetic-powder-on-membrane-fouling-mitigation-and-microbial-community-composition-in-membrane-bioreactors-mbrs-for-municipal-wastewater-treatment
#2
Yi Liu, Qiang Liu, Jixiang Li, Huu Hao Ngo, Wenshan Guo, Jiajun Hu, Min-Tian Gao, Qiyuan Wang, Yuansheng Hou
This study aims to investigate the usefulness of magnetic powder addition in membrane bioreactors (MBRs) for membrane fouling mitigation and its effect on microbial community and composition. The comparison between the two MBRs (one with magnetic powder (MAS-MBR) and one without magnetic powder (C-MBR)) was carried out to treat synthetic municipal wastewater. Results showed that bioflocculation and adsorption of magnetic powder contributed only minimally to membrane fouling mitigation while the slower fouling rate might be ascribed to magnetic bio-effect...
October 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29055146/association-between-natural-killer-cell-activity-and-the-risk-of-colorectal-neoplasia
#3
Yoon Suk Jung, Min-Jung Kwon, Dong Il Park, Chong Il Sohn, Jung Ho Park
BACKGROUND: Low activity of natural killer (NK) cells is known to be associated with higher risk of cancer, especially with poor prognosis and the presence of colorectal cancer (CRC). We investigated whether NK cells activity differs between subjects with and without colorectal neoplasia (CRN). METHODS: A cross-sectional study was performed on 1818 asymptomatic examinees aged ≥30 years who underwent NK cell activity test (which quantitates the amount of interferon-γ secreted into the plasma by NK cells) and a colonoscopy as part of a health check-up...
October 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29055108/semi-quantitative-analysis-of-tramadol-dextromethorphan-and-metabolites-in-decomposed-skeletal-tissues-by-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-uplc-qtof-ms
#4
H M Cornthwaite, L Labine, J H Watterson
The use of filtration/pass-through extraction (FPTE) and ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-qTOF-MS) to detect tramadol (TRAM), dextromethorphan (DXM) and metabolites from skeletal remains is described. Rats (n=5) received 50 mg/kg tramadol and were euthanized by CO2 asphyxiation approximately 30 min post-dose. Rats (n=4) received 75 mg/kg dextromethorphan and were euthanized by CO2 asphyxiation approximately 45 min post-dose. Remains decomposed to skeleton outdoors and vertebral bones were collected...
October 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29055041/the-possible-clinical-impact-of-risperidone-on-p-glycoprotein-mediated-transport-of-tacrolimus-a-case-report-and-in-vitro-study
#5
Nao Watanabe, Hiroki Higashi, Saki Nakamura, Keiko Nomura, Yuichi Adachi, Masato Taguchi
The authors encountered the case of an 8-fold increase in the concentration/dose (C/D) ratio of tacrolimus (TAC) following the coadministration of voriconazole (VRCZ) in a hematopoietic stem cell transplantation (HSCT) recipient. The interaction observed was much greater than expected and the patient had also been treated with oral risperidone (RSP). We hypothesized that cytochrome P450 (CYP)3A inhibition of the small intestine by VRCZ and P-glycoprotein (P-gp) inhibition of the small intestine by RSP exerted a synergistic effect on the bioavailability of TAC...
October 20, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29054915/prevalence-of-sleep-apnoea-and-capnographic-detection-of-nocturnal-hypoventilation-in-amyotrophic-lateral-sclerosis
#6
Matthias Boentert, Christian Glatz, Cornelia Helmle, Angelika Okegwo, Peter Young
OBJECTIVE: This retrospective study aimed to investigate whether overnight oxymetry and early morning blood gas analysis predict nocturnal hypoventilation (NH) as reflected by night-time hypercapnia in patients with amyotrophic lateral sclerosis (ALS). In addition, prevalence and clinical determinants of sleep apnoea in ALS were evaluated. METHODS: In 250 patients with non-ventilated ALS, transcutaneous capnometry was performed along with polysomnography or polygraphy and early morning blood gases...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29054846/diabetes-and-ckd-in-the-united-states-population-2009-2014
#7
Leila R Zelnick, Noel S Weiss, Bryan R Kestenbaum, Cassianne Robinson-Cohen, Patrick J Heagerty, Katherine Tuttle, Yoshio N Hall, Irl B Hirsch, Ian H de Boer
BACKGROUND AND OBJECTIVES: Diabetes is an important cause of CKD. However, among people with diabetes, it is unclear to what extent CKD is attributable to diabetes itself versus comorbid conditions, such as advanced age and hypertension. We examined associations of diabetes with clinical manifestations of CKD independent of age and BP and the extent to which diabetes contributes to the overall prevalence of CKD in the United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a cross-sectional study of 15,675 participants in the National Health and Nutrition Examination Surveys from 2009 to 2014...
October 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29054827/characterization-of-a-double-wap-domain-containing-protein-from-the-red-swamp-crayfish-procambarus-clarkii
#8
Hong-Wei Zhang, Xin Man, Yue Wang, Qi-Sheng Song, David Stanley, Kai-Min Hui, Xiao-Wen Zhang
Crustaceans express multiple whey acidic protein (WAP) domain containing proteins which are components of host immunity. In the present study, a new double WAP domain containing protein was identified from red swamp crayfish Procambarus clarkii, designated Pc-DWD. The ORF is 387 bp, encoding 128 amino acids consisting of signal peptide of 18 residues, and two tandem WAP domains of 38 and 44 residues. Multiple alignment indicates the presence of conserved motifs in both WAP domains, and phylogenetic analysis shows that Pc-DWD is a new member of the type-IV crustin family...
October 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29054803/comparison-of-short-term-effects-of-mobilization-with-movement-and-kinesiotaping-on-pain-function-and-balance-in-patellofemoral-pain
#9
Serdar Demirci, Gizem Irem Kinikli, Michael J Callaghan, Volga Bayrakci Tunay
OBJECTIVE: The aim of this study was to compare the short-term effects of Mobilization with movement (MWM) and Kinesiotaping (KT) on patients with patellofemoral pain (PFP) respect to pain, function and balance. METHODS: Thirty-five female patients diagnosed with unilateral PFP were assigned into 2 groups. The first group (n = 18) received two techniques of MWM intervention (Straight Leg-Raise with Traction and Tibial Gliding) while KT was applied to the other group (n = 17)...
October 17, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29054773/microsurgical-vs-endovascular-treatments-for-blood-blister-aneurysms-of-the-internal-carotid-artery-a-retrospective-study-of-83-patients-in-a-single-center
#10
Yanming Ren, Lunxin Liu, Hong Sun, Yi Liu, Hao Li, Lu Ma, Chang-Wei Zhang, Xiao-Dong Xie, Min He, Chao You, Jin Li
BACKGROUND: Blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) are challenging lesions with high morbidity and mortality. Currently, both surgical and endovascular approaches have been used to treat the BBAs; however, little is known about their safety and efficacy. OBJECTIVE: To review our experience with the treatment of BBAs and explore the optimal treatment strategy. METHODS: A total of 83 patients with BBAs were reviewed retrospectively...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054743/simultaneous-rna-seq-based-transcriptional-profiling-of-intracellular-brucella-abortus-and-b-abortus-infected-murine-macrophages
#11
Huynh Tan Hop, Lauren Togonon Arayan, Alisha Wehdnesday Bernardo Reyes, Tran Xuan Ngoc Huy, WonGi Min, Hu Jang Lee, Jee Soo Son, Suk Kim
Brucella is a zoonotic pathogen that survives within macrophages; however the replicative mechanisms involved are not fully understood. We describe the isolation of sufficient Brucella abortus RNA from primary host cell environment using modified reported methods for RNA-seq analysis, and simultaneously characterize the transcriptional profiles of intracellular B. abortus and bone marrow-derived macrophages (BMM) from BALB/c mice at 24 h (replicative phase) post-infection. Our results revealed that 25.12% (801/3190) and 16...
October 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29054725/accelerometer-based-and-computer-assisted-navigation-in-total-knee-arthroplasty-a-reduction-in-mechanical-axis-outliers-does-not-lead-to-improvement-in-functional-outcomes-or-quality-of-life-when-compared-to-conventional-total-knee-arthroplasty
#12
Graham Seow-Hng Goh, Ming Han Lincoln Liow, Darren Keng-Jin Tay, Ngai-Nung Lo, Seng-Jin Yeo, Mann-Hong Tan
BACKGROUND: Accelerometer-based navigation (ABN) is a novel navigation system that attempts to combine the accuracy of computer-assisted surgery (CAS) with the familiarity of conventional instrumentation (CON). No studies have compared the clinical outcomes of this new technology with existing techniques to date. METHODS: From July 2013 to April 2014, 152 consecutive patients (152 knees) underwent total knee arthroplasty using ABN (n = 38), CAS (n = 38), or CON (n = 76)...
September 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29054699/silymarin-attenuated-paraquat-induced-cytotoxicity-in-macrophage-by-regulating-trx-txnip-complex-inhibiting-nlrp3-inflammasome-activation-and-apoptosis
#13
Zhenning Liu, Mingli Sun, Yu Wang, Lichun Zhang, Hang Zhao, Min Zhao
Oxidative stress and inflammation are involved in paraquat-induced cytotoxicity. Silymarin can exert a potent antioxidative and anti-inflammatory effect in various pathophysiological processes. The aim of this current study is to explore the protective effect and potential mechanism of silymarin in paraquat-induced macrophage injury. Cells were pretreated with different doses of silymarin for 3h before exposure to paraquat. At 24h after exposure to paraquat, the paraquat-induced cytotoxicity to macrophage was measured via the MTT assay and LDH release...
October 17, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29054507/comparison-of-a-web-based-teaching-tool-and-traditional-didactic-learning-for-in-vitro-fertilization-patients-a-preliminary-randomized-controlled-trial
#14
Tannys Dawn Reiko Vause, David J Allison, Tricia Vause, Ayda Tekok-Kilic, David S Ditor, Jason K Min
OBJECTIVE: The objective of this prospective RCT was to compare the efficacy of a web-based teaching tool to traditional didactic teaching in IVF patients. METHODS: Forty women undergoing their first IVF cycle were randomly allocated to an interactive web-based teaching session or a nurse-led didactic teaching session. The primary outcome measure was participant knowledge regarding the IVF process, risks, and logistics assessed before and after the respective teaching session...
October 17, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29054505/biomonitor-2-pilot-study-early-experience-with-implantation-of-the-biotronik-biomonitor-2-implantable-cardiac-monitor
#15
Sze-Yuan Ooi, Ben Ng, Suresh Singarayar, Kevin Hellestrand, Peter Illes, Uwais Mohamed, Shakeeb Razak, Rukshen Weerasooriya
BACKGROUND: The BioMonitor 2 Pilot Study assessed the implantation procedure, the sensing amplitude and the remote monitoring transmission success rate of the second generation implantable cardiac monitor, the BioMonitor 2 (Biotronik, Berlin, Germany). METHODS: This was a prospective, multi-centre, single-arm, non-randomised study involving seven operators in five sites across Australia. Data were collected at implantation, during clinic visits at 1 week and 1 month post-implantation, and through wireless remote monitoring...
October 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29054454/senescent-hepatocyte-secretion-of-matrix-metalloproteinases-is-regulated-by-nuclear-factor-%C3%AE%C2%BAb-signaling
#16
Jinfeng Zang, Min Sha, Chi Zhang, Jun Ye, Kezhi Zhang, Junye Gao
AIMS: Cellular senescence and matrix metalloproteinases (MMPs) play an important role in liver diseases. The source and regulating factors of MMPs in senescent hepatocytes are not known. We investigated whether senescent hepatocytes secreted MMPs and if this was regulated by nuclear factor (NF)-κB. MATERIALS AND METHODS: The TGF-α transgenic mouse hepatocyte line AML12 was treated with H2O2 to induce senescence. NF-κB signaling was examined by Western blotting and luciferase reporter assays...
October 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/29054384/arthroscopic-subscapularis-repair-using-single-row-mattress-suture-technique-clinical-results-and-structural-integrity
#17
Jeung Yeol Jeong, Hai-Le Pan, Seung Yeop Song, Sang Min Lee, Jae Chul Yoo
BACKGROUND: Rupture of the subscapularis (SSC) tendon, isolated or combined, is rare, and the treatment modalities are controversial. The purpose of this study was to evaluate, by magnetic resonance imaging (MRI), the clinical outcomes and structural integrity of the SSC tendon after all-arthroscopic repair with single-row mattress suture for isolated or combined SSC tendon tears. METHODS: This study included 68 patients who underwent all-arthroscopic repair using single-row mattress suture for isolated or combined SSC tendon tears between April 2011 and January 2013...
October 17, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29054302/monitoring-the-biomechanical-and-physiological-effects-of-postural-changes-during-leisure-chair-sitting
#18
Peter R Worsley, Dan Rebolledo, Sally Webb, Silvia Caggiari, Dan L Bader
BACKGROUND: Individuals with limited mobility can spend prolonged periods in leisure chairs, increasing their risk of developing a seated acquired pressure ulcer. The present study aims to use objective measures of posture and tissue viability to identify the associated risks of leisure chair related pressure ulcers. METHODS: Healthy participants (n = 13) were recruited to sit on a leisure chair with either a viscoelastic foam or air cushion. Participants were asked to adopt four different postures for a period of 10 min followed by a 10 min refractory period...
October 12, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29054287/differential-modulatory-effects-of-cocaine-on-marmoset-monkey-recognition-memory
#19
Jonathan L Melamed, Fernando M de Jesus, Jéssica Aquino, Clarissa R S Vannuchi, Renata B M Duarte, Rafael S Maior, Carlos Tomaz, Marilia Barros
Acute and repeated exposure to cocaine alters the cognitive performance of humans and animals. How each administration schedule affects the same memory task has yet to be properly established in nonhuman primates. Therefore, we assessed the performance of marmoset monkeys in a spontaneous object-location (SOL) recognition memory task after acute and repeated exposure to cocaine (COC; 5mg/kg, ip). Two identical neutral stimuli were explored on the 10-min sample trial, after which preferential exploration of the displaced vs the stationary object was analyzed on the 10-min test trial...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29054260/edge-enhancement-algorithm-for-low-dose-x-ray-fluoroscopic-imaging
#20
Min Seok Lee, Chul Hee Park, Moon Gi Kang
BACKGROUND AND OBJECTIVE: Low-dose X-ray fluoroscopy has continually evolved to reduce radiation risk to patients during clinical diagnosis and surgery. However, the reduction in dose exposure causes quality degradation of the acquired images. In general, an X-ray device has a time-average pre-processor to remove the generated quantum noise. However, this pre-processor causes blurring and artifacts within the moving edge regions, and noise remains in the image. During high-pass filtering (HPF) to enhance edge detail, this noise in the image is amplified...
December 2017: Computer Methods and Programs in Biomedicine
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