Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Maria Hjorth, Anncarin Svanberg, Riccardo LoMartire, Elenor Kaminsky, Fredrik Rorsman
BACKGROUND: Cirrhosis treatment implies prevention and alleviation of serious disease events. Healthcare providers may, however, fail to meet patients' expectations of collaboration and specific needs of information and support. Individualised nursing care could meet patients' needs. The aim was thus to measure patient-perceived quality of care after adjunctive registered nurse-based intervention Quality Liver Nursing Care Model (QLiNCaM) compared with standard medical care. METHODS: This pragmatic multicentre study consecutively randomised patients to either adjunctive registered nurse-based care, or standard medical care for 24 months (ClinicalTrials...
April 19, 2024: BMC Nursing
#22
JOURNAL ARTICLE
Ankur Jindal, Hitesh Singh, Guresh Kumar, Vinod Arora, Manoj Kumar Sharma, Rakhi Maiwall, V Rajan, Harsh Vardhan Tewathia, Chitranshu Vasishtha, Shiv Kumar Sarin
BACKGROUND AND AIMS: Terlipressin infusion is effective in hepatorenal syndrome (HRS-AKI). However, its efficacy for HRS-AKI resolution in acute-on-chronic liver failure (ACLF) patients has been suboptimal. Progression of AKI is rapid in ACLF. We investigated whether early initiation of terlipressin(eTerli) can improve response rates. METHODS: Consecutive ACLF patients with stage II/III AKI despite albumin resuscitation (40 g) were randomized to receive terlipressin at 2 mg/24 h plus albumin at 12 h (ET, n = 35) or at 48 h as standard therapy (ST, n = 35)...
April 18, 2024: Digestive Diseases and Sciences
#23
JOURNAL ARTICLE
Bram Brouwers, Girish Rao, Yuanyuan Tang, Ángel Rodríguez, Leonard C Glass, Mark L Hartman
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most common form of chronic liver disease. It exists as either simple steatosis or its more progressive form, metabolic dysfunction-associated steatohepatitis (MASH), formerly, non-alcoholic steatohepatitis (NASH). The global prevalence of MASLD is estimated to be 32% among adults and is projected to continue to rise with increasing rates of obesity, type 2 diabetes, and metabolic syndrome...
April 16, 2024: Diabetes Research and Clinical Practice
#24
JOURNAL ARTICLE
Emmanuel A Tsochatzis, Luca Valenti, Maja Thiele, Sophie Péloquin, Patrice Lazure, Mounia Heddad Masson, Alina M Allen, Jeffrey V Lazarus, Mazen Noureddin, Mary Rinella, Frank Tacke, Suzanne Murray
BACKGROUND AND AIMS: Non-invasive tests (NITs) are underutilized for diagnosis and risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD), despite good accuracy. This study aimed to identify challenges and barriers to the use of NITs in clinical practice. METHODS: We conducted a qualitative exploratory study in Germany, Italy, United Kingdom and United States. Phase 1 participants (primary care physicians, hepatologists, diabetologists, researchers, healthcare administrators, payers and patient advocates; n = 29) were interviewed...
April 18, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
#25
JOURNAL ARTICLE
Marta Garcia-Guix, Alba Ardevol, Victor Sapena, Edilmar Alvarado-Tápias, Anna Huertas, Anna Brujats, Javier Fajardo, Berta Cuyas, María Poca, Carlos Guarner, Xavier Torras, Àngels Escorsell, Càndid Villanueva
BACKGROUND AND AIMS: Decompensated-cirrhosis encompasses several stages with different prognosis, such as bleeding, ascites and bleeding-plus-ascites. Development of further-decompensation worsens survival, while non-selective β-blockers (NSBBs) can modify the risk. However, how this applies to each stage is uncertain. We aimed to investigate, in each stage of decompensated-cirrhosis, the influence of further-decompensation on mortality and whether changes in portal-pressure (HVPG) under NSBBs influence these outcomes...
April 18, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
#26
JOURNAL ARTICLE
Shunhua Qiu, Lifen Jin, Dan Yang, Dewen Zhang
BACKGROUND: Chronic hepatitis B virus (HBV) infection is a severe disease affecting the physical and economic well-being of patients. The relationship between polymorphisms in the MTHFR gene and disease progression following HBV infection remains a controversial topic. AIM: To study MTHFR and MTRR gene polymorphisms in patients with chronic HBV infections in Zigong, Sichuan Province. SUBJECTS AND METHODS: One hundred and ninety-one patients with chronic HBV infections were divided into three groups: the chronic hepatitis B (CHB) group ( n = 71), the hepatitis B-induced liver cirrhosis (LC) group ( n = 56), and the hepatitis B-related primary liver cancer (PLC) group ( n = 64)...
February 2024: Annals of Human Biology
#27
Sayan Malakar, Nishant Shah, Ankit Mishra, Vipin Pandey, Vivek V Shirol, Naganath K Wodeyar, Prabhat Verma, Sai Prathap, Kartik Balankhe, Ramnawal Rao, Uday C Ghoshal
Acute viral hepatitis E (HEV) is the most common form of acute viral hepatitis in India. It is associated with self-limiting disease in most cases. However, the chronic form of HEV is also being increasingly recognized. Other viral infections like the hepatitis A virus (HAV) have been implicated in inciting autoimmune hepatitis. HEV infection has been associated with the formation of circulating liver-directed autoantibodies, however autoimmune liver disease following acute HEV infection has been rarely reported...
March 2024: Curēus
#28
Soichiro Okamoto, Yusuke Matsui, Shoichi Komoto, Takao Hiraki
We report the rare case of an 80-year-old man with hepatocellular carcinoma that ruptured in the gallbladder, causing a cystic artery pseudoaneurysm and hemobilia. Emergency transarterial embolization (TAE) successfully controlled the bleeding without causing ischemic cholecystitis. Cone-beam computed tomography angiography was useful in identifying the bleeding branch of the selectively embolized cystic artery. Although the patient had poor liver function (Child-Pugh class C) before TAE, it remarkably improved after embolization due to the resolution of coagulopathy and obstructive jaundice caused by hemobilia...
March 2024: Curēus
#29
JOURNAL ARTICLE
Andrea Cavallaro, Antonio Zanghì, Maria Di Vita, Vito Emanuele Catania, Giovanni Longo, Emanuele Lo Menzo, Roberta Granata, Maria Rosaria Valenti, Alessandro Cappellani, Simone Di Majo
INTRODUCTION: Gastric antral vascular ectasia (GAVE) is a rare cause of chronic or acute gastrointestinal bleeding. This condition accounts for ∼4% of upper gastrointestinal bleeding cases. This disease is often associated with systemic diseases, such as liver cirrhosis, chronic kidney failure, autoimmune conditions, diabetes mellitus, hypothyroidism, and cardiovascular diseases. However, its etiopathogenesis remains controversial. MATERIALS AND METHOD: We retrospectively reviewed the cases of GAVE treated at our digestive surgery unit...
2024: Frontiers in Surgery
#30
REVIEW
Pınar Korkmaz, Ali Asan, Faruk Karakeçili, Süda Tekin, Neşe Demirtürk
Hepatitis B virus (HBV) infection is the leading cause of chronic liver disease worldwide. HBV-infected patients are at a lifetime risk of developing liver cirrhosis and hepatocellular carcinoma (HCC). Today, pegylated interferon (Peg-IFN) and nucleos(t)ide analogs (NAs) are used in the treatment of patients with chronic hepatitis B (CHB). Both treatment options have limitations. Despite effective viral suppression, NAs have little effect on covalently closed circular DNA (cccDNA), the stable episomal form of the HBV genome in hepatocytes...
December 2023: Infect Dis Clin Microbiol
#31
JOURNAL ARTICLE
Shanshan Xu, Xiao-Hang Wu, Lin Wu, Jia-Min Zhai, Shi-Jun Li, Yichuan Kou, Wei Peng, Qing-Na Zheng, Jing-Hua Tian, Yue-Jiao Zhang, Jian-Feng Li
Hepatitis B virus (HBV) is a major cause of liver cirrhosis and hepatocellular carcinoma, with HBV surface antigen (HBsAg) being a crucial marker in the clinical detection of HBV. Due to the significant harm and ease of transmission associated with HBV, HBsAg testing has become an essential part of preoperative assessments, particularly for emergency surgeries where healthcare professionals face exposure risks. Therefore, a timely and accurate detection method for HBsAg is urgently needed. In this study, a surface-enhanced Raman scattering (SERS) sensor with a sandwich structure was developed for HBsAg detection...
April 18, 2024: Analytical Chemistry
#32
JOURNAL ARTICLE
Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Gustav Ahlberg, Vinicius Tragante, Søren A Rand, Joseph Brancale, Silvia Vilarinho, Pia Rengtved Lundegaard, Erik Sørensen, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, Søren Brunak, Karina Banasik, Henrik Ullum, Niek Verweij, Luca Lotta, Aris Baras, Tooraj Mirshahi, David J Carey, David E Kaplan, Julie Lynch, Timothy Morgan, Tae-Hwi Schwantes-An, Daniel R Dochtermann, Saiju Pyarajan, Philip S Tsao, Triin Laisk, Reedik Mägi, Julia Kozlitina, Anne Tybjærg-Hansen, David Jones, Kirk U Knowlton, Lincoln Nadauld, Egil Ferkingstad, Einar S Björnsson, Magnus O Ulfarsson, Árni Sturluson, Patrick Sulem, Ole B Pedersen, Sisse R Ostrowski, Daniel F Gudbjartsson, Kari Stefansson, Morten Salling Olesen, Kyong-Mi Chang, Hilma Holm, Henning Bundgaard, Stefan Stender
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism...
April 17, 2024: Nature Genetics
#33
REVIEW
Jamshid Roozbeh, Shahrokh Ezzatzadegan Jahromi, Mohamad Hossein Rezazadeh, Anahid Hamidianjahromi, Leila Malekmakan
BACKGROUND: Hepatorenal syndrome (HRS), a multiorgan condition of acute kidney injury, is seen in advanced liver disease. This study aims to evaluate the current treatment for HRS. METHODS: The authors searched PubMed, Scopus and Google Scholar literature. After quality assessment, 31 studies were included in this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology and the population, intervention, comparison and outcome scheme were used...
April 17, 2024: BMJ Open Gastroenterology
#34
JOURNAL ARTICLE
Shaohua Shi, Minghui Zhang, Xuliang Chen, Zhuoyi Wang, Songming Ding, Zhitao Chen, Yu Yang, Shusen Zheng
No abstract text is available yet for this article.
April 17, 2024: Chinese Medical Journal
#35
JOURNAL ARTICLE
Chengnan Guo, Zhenqiu Liu, Hong Fan, Haili Wang, Xin Zhang, Shuzhen Zhao, Yi Li, Xinyu Han, Tianye Wang, Xingdong Chen, Tiejun Zhang
BACKGROUND AND AIMS: The liver cirrhosis complications occur after long asymptomatic stages of progressive fibrosis and are generally diagnosed late. We aimed to develop a plasma metabolomic-based score tool to predict these events. APPROACH AND RESULTS: We enrolled 64,005 UK biobank participants with metabolomic profile. Participants were randomly divided into the training (n=43,734) and validation cohorts (n=20,271). Liver cirrhosis complications were defined as hospitalization for liver cirrhosis or presentation with hepatocellular carcinoma...
April 17, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#36
JOURNAL ARTICLE
Anja Schollmeier, Michael Basic, Mirco Glitscher, Eberhard Hildt
Chronic hepatitis B virus (HBV) infections are strongly associated with liver cirrhosis, inflammation, and hepatocellular carcinoma. In this context, the viral HBx protein is considered as a major factor influencing HBV-associated pathogenesis through deregulation of multiple cellular signaling pathways and is therefore a potential target for prognostic and therapeutic applications. However, HBV-associated pathogenesis differs significantly between genotypes, with the relevant factors and in particular the contribution of the genetic diversity of HBx being largely unknown...
April 17, 2024: Journal of Virology
#37
JOURNAL ARTICLE
Pingping Zhou, Jun Yang
The hepatopulmonary syndrome (HPS) is characterized by arterial oxygenation defect induced by intrapulmonary vascular dilatations in the setting of liver disease. We report a 57-year-old woman with a history of liver cirrhosis presented with progressive cyanosis, exertional dyspnea and a dry cough. Oxyhemoglobin saturation was 88.5% on room air. Contrast transthoracic echocardiography (cTTE) and technetium-99m-macroaggregated albumin (99m Tc-MAA) scintigraphy showed an intrapulmonary shunting and confirmed HPS...
April 18, 2024: Hellenic Journal of Nuclear Medicine
#38
JOURNAL ARTICLE
Maria Mironova, Harish Gopalakrishna, Gracia Maria Viana Rodriguez, Nehna Abdul Majeed, Asif A Hitawala, Ivan J Fuss, Jenna R E Bergerson, Alison J Faust, Jacqueline M Laurin, Jaha Norman-Wheeler, Shani Scott, Julian Hercun, Bernadette Redd, David E Kleiner, Christopher Koh, Theo Heller
BACKGROUND: Non-cirrhotic portal hypertension (NCPH) is a spectrum of liver diseases, including porto-sinusoidal vascular disorder, with portal hypertension (PH) in the absence of cirrhosis. The natural history and diagnostic approach to NCPH are not well understood. AIM: We aimed to evaluate disease progression and outcomes in NCPH. METHODS: Patients with or at risk for NCPH were enrolled in a single centre prospective study; two groups were formed based on the presence of specific features of PH, such as varices, collaterals, portal hypertensive gastropathy or portal hypertensive bleeding...
April 17, 2024: Alimentary Pharmacology & Therapeutics
#39
JOURNAL ARTICLE
Marlone Cunha-Silva, Clauber Teles Veiga, Larissa Bastos Eloy da Costa, Simone Reges Perales, Amanda Avesani Cavotto Furlan, Elaine Cristina de Ataíde, Ilka de Fátima Santana Ferreira Boin, Tiago Sevá-Pereira
Giant hepatic hemangiomas are occasional in patients with cirrhosis. It remains a challenge to decide on the need for treatment and choose the most appropriate intervention. A 62-year-old woman was recently diagnosed with cirrhosis and complained of upper abdominal fullness, reduction in oral food intake, and weight loss of 6 kg over the last three years. Upper digestive endoscopy evidenced thin-caliber esophageal varices and significant extrinsic compression of the lesser gastric curvature. Abdominal computed tomography revealed an exophytic tumor in the left hepatic lobe, measuring 11...
2024: Autopsy & Case Reports
#40
JOURNAL ARTICLE
Bradly Brown, Peter E Frasco, Alexander D Stoker
BACKGROUND A paradoxical air embolism (PAE) occurs when air entering the central venous circulation reaches the systemic circulation, occurring through an intracardiac shunt or intrapulmonary shunting. Patients presenting for liver transplantation often have intrapulmonary shunting due to pulmonary arterial vasodilation, even in the absence of hepatopulmonary syndrome. Here, we present a case of hemodynamic collapse believed to be caused by a PAE, which was diagnosed intraoperatively with transesophageal echocardiography (TEE)...
April 17, 2024: American Journal of Case Reports
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
