Xiaodong Zhuang, Giulia Gallo, Parul Sharma, Jiyeon Ha, Andrea Magri, Helene Borrmann, James M Harris, Senko Tsukuda, Eleanor Bentley, Adam Kirby, Simon de Neck, Hongbing Yang, Peter Balfe, Peter A C Wing, David Matthews, Adrian L Harris, Anja Kipar, James P Stewart, Dalan Bailey, Jane A McKeating
Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limited. Hypoxia inducible factors (HIFs) define metabolic responses to low oxygen and regulate inflammatory responses in the lower respiratory tract. We demonstrate a role for HIFs to suppress RSV entry and RNA replication. We show that hypoxia and HIF prolyl-hydroxylase inhibitors reduce the expression of the RSV entry receptor nucleolin and inhibit viral cell-cell fusion...
January 19, 2024: IScience