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https://www.readbyqxmd.com/read/28424132/outcomes-of-recreational-activity-associated-trauma-in-elderly-persons-on-blood-thinning-medications
#1
Zachary M DeBoard, Jonathan Grotts, Lisa Ferrigno
With increasing life expectancy, the elderly are participating in recreational activities traditionally pursued by younger persons. Elderly patients have many reasons for worse outcomes after trauma, one of which may be the rising use of anticoagulant and/or antiplatelet medications. This study aimed to determine whether preinjury use of these agents yielded worse outcomes in geriatric patients injured during high-impact recreational activities. The National Trauma Data Bank was reviewed from 2007 to 2010 for patients ≥65 years admitted to Level I or II trauma centers with ICD-9 E-codes for specific mechanisms of injury...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28416566/structure-of-deah-rha-atpase-prp43p-bound-to-rna-implicates-a-pair-of-hairpins-and-motif-va-in-translocation-along-rna
#2
Yangzi He, Jonathan P Staley, Gregers Rom Andersen, Klaus H Nielsen
Three families of nucleic acid-dependent ATPases (DEAH/RHA, Ski2-like and NS3/NPH-II), termed the DExH ATPases, are thought to execute myriad functions by processive, ATP-dependent, 3' to 5' translocation along single-stranded nucleic acid. While the mechanism of translocation of the viral NS3/NPH-II family has been studied extensively, it has not been clear if or how the principles that have emerged for this family extend to the other two families. Here we report the crystal structure of the yeast DEAH/RHA family ATPase Prp43p, which functions in splicing and ribosome biogenesis, in complex with poly-uracil and a non-hydrolysable ATP analogue...
April 17, 2017: RNA
https://www.readbyqxmd.com/read/28415868/-epidemiological-data-of-hungarian-skiers-and-snowboarders-medical-problems
#3
Péter Felkai, Ingrid Lengyel, Miklós Szokoly, Gábor Forgó
INTRODUCTION AND AIM: There are no high mountains or any advantageous circumstances for winter sports in Hungary, yet within the 10 million population there are about half a million people (the exact number is 550,000) who tend to go for skiing or snowboarding abroad. Authors compared the injury statistical data with results described in the international literature in order to develop conclusions about the differences in the injury patterns and frequency between the Hungarian ones' and those found in countries with plenty of winter sport possibilities...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28408609/skiing-for-science
#4
Daniel T Blumstein
No abstract text is available yet for this article.
April 14, 2017: Science
https://www.readbyqxmd.com/read/28405684/sphk1-modulates-cell-migration-and-emt-related-marker-expression-by-regulating-the-expression-of-p-fak-in-colorectal-cancer-cells
#5
Chun-Yan Xu, Shi-Quan Liu, Meng-Bin Qin, Chun-Feng Zhuge, Lin Qin, Nan Qin, Ming-Yu Lai, Jie-An Huang
Sphingosine kinase 1 (SphK1) plays an important role in colorectal carcinoma metastasis. However, whether SphK1 modulates epithelial-mesenchymal transition (EMT)-related marker expression and the underlying mechanisms remain unclear. In this study, in order to clarify this issue, we used various colorectal cancer (CRC) cell lines, Caco2, HT29, RKO and HCT116. Each of the cell lines was divided into 3 groups as follows: the control group, SKI-Ⅱ (SphK1 inhibitor) group and PF-562271 [focal adhesion kinase (FAK) inhibitor] group...
May 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28398944/alpine-skiing-as-winter-time-high-intensity-training
#6
Thomas Stöggl, Christoph Schwarzl, Edith E Müller, Masaru Nagasaki, Julia Stöggl, Martin Schönfelder, Josef Niebauer
INTRODUCTION: To counteract the winter activity deficit, we set out to analyze cardiorespiratory and metabolic responses of two high intensity training (HIT) protocols during alpine skiing (AS), cross-country skiing (XCS) and indoor cycling (IC) and the effects of sex, age and fitness level in this comparison. METHODS: Nineteen healthy subjects (two age and fitness groups, both sexes) performed AS, XCS, and IC with measurements of oxygen uptake (VO2), energy expenditure (EE), heart rate (HR), lactate, blood glucose and rate of perceived exertion, determined during 4-min of continuous high intensity (HITc: 90% HRmax for XCS and IC or short turn skiing during AS) or 10-min intermittent HIT [HITint: 5x1' high intensity (>90% HRmax or short turn skiing), 1' active recovery]...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28398634/ski-regulates-smads-and-taz-signaling-to-suppress-lung-cancer-progression
#7
Mian Xie, Xiaojun Wu, Jinjun Zhang, Jiexia Zhang, Xiangxiang Li
Ski, the transforming protein of the avian Sloan-Kettering retrovirus, displays both pro-oncogenic and anti-oncogenic activities in human cancer. The mechanisms underlying these conflicting observations have not been fully understood. Herein, we investigated the mechanism underlying the tumor suppressor activity of Ski. To investigate the effect of Ski re-activation on TGF-β and Hippo/TAZ pathway, we measured its effect on the endogenous Smad target genes (PAI-1 and P15(INK4B) ) and TAZ target gene CTGF. The results revealed that Ski exerted its inhibitory activity in TGF-β1/Smad signaling pathway...
April 11, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28397834/snon-stabilizes-the-smad3-smad4-protein-complex
#8
Karin Walldén, Tomas Nyman, B Martin Hällberg
TGF-β signaling regulates cellular processes such as proliferation, differentiation and apoptosis through activation of SMAD transcription factors that are in turn modulated by members of the Ski-SnoN family. In this process, Ski has been shown to negatively modulate TGF-β signaling by disrupting active R-SMAD/Co-SMAD heteromers. Here, we show that the related regulator SnoN forms a stable complex with the R-SMAD (SMAD3) and the Co-SMAD (SMAD4). To rationalize this stabilization at the molecular level, we determined the crystal structure of a complex between the SAND domain of SnoN and the MH2-domain of SMAD4...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394833/optimizing-half-squat-post-activation-potential-load-in-squat-jump-training-for-eliciting-relative-maximal-power-in-ski-jumpers
#9
A Gołaś, M Wilk, P Statsny, A Maszczyk, K Pajerska, A Zajac
Training load manipulation in a single workout session can increase or decrease training effectiveness in terms of athlete's strength or power gains. In ski jumping the complex training that elicits maximal power gains may take advantage of the post activation potentiation mechanism (PAP). The aim of research was to evaluate the changes in rate of force development (RFD), rate of power development (RPD) and jump height during a complex training session consisted of the barbell half squat (Sq) as an conditioning exercise with loads ranged between 60-100% of 1 repetition maximum (1RM), followed by a body weight squat jump (SqJ) as a performance task...
April 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28382550/sitting-position-affects-performance-in-cross-country-sit-skiing
#10
M Lund Ohlsson, M S Laaksonen
PURPOSE: In cross-country sit-skiing (XCSS), athletes with reduced trunk control predominantly sit with the knees higher than the hips (KH); a position often associated with large spinal flexion. Therefore, to improve spinal curvature a new sledge with frontal trunk support, where knees are lower than hips (KL) was created. It was hypothesized that the KL position would improve respiratory function and enhance performance in seated double-poling compared to KH. METHODS: Ten female able-bodied cross-country skiers (age 25...
April 5, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28370704/dyadic-incongruence-in-chronic-heart-failure-implications-for-patient-and-carer-psychological-health-and-self-care
#11
Jan Cameron, David R Thompson, Dion Szer, Joannah Greig, Chantal F Ski
AIM AND OBJECTIVES: To examine whether chronic heart failure (CHF) patient-carer dyads who disagree about the division of illness management tasks (incongruent) experience poorer psychosocial health and self-care, than those who agree (congruent). BACKGROUND: Informal carers often assist patients with (CHF) in the complex management of their illness but little is known about how relationship dynamics may affect psychosocial health. DESIGN: A prospective cross-sectional study was adopted with a purposeful sample of 25 CHF patient-carer dyads residing in Australia...
March 30, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28351605/infections-associated-with-adventure-travel-a-systematic-review
#12
REVIEW
Nathan D Gundacker, Robert J Rolfe, J Martin Rodriguez
AIM: To review infections associated with adventure travel. METHODS: The PubMed, Embase and Scopus databases were searched combining the words infection with the following keywords: rafting, whitewater, surfing, (surfer* or windsurf*), (caves or caving or spelunking), (triathlon or trekking) or (hiking or adventure race), bicycling, backpacking, (mountain climb* or bouldering), horseback riding, orienteering, trekking, and skiing. RESULTS: Adventure travel is becoming much more common among travelers and it is associated with a subset of infectious diseases including: leptospirosis, schistosomiasis, viral hemorrhagic fevers, rickettsial diseases and endemic mycosis...
March 27, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28349621/-it-feels-sometimes-like-my-house-has-burnt-down-but-i-can-see-the-sky-a-qualitative-study-exploring-patients-views-of-cognitive-behavioural-therapy-for-chronic-fatigue-syndrome
#13
Federica Picariello, Sheila Ali, Caroline Foubister, Trudie Chalder
OBJECTIVES: Cognitive behavioural therapy (CBT) is currently a first-line treatment for chronic fatigue syndrome (CFS). Even though the results from trials are promising, there is variability in patient outcomes. The aim of this study was to explore the experiences of patients with CFS who undertook CBT at a specialist service for CFS. DESIGN: This was a qualitative study. METHODS: Thirteen patients with CFS, approaching the end of CBT, participated in semi-structured interviews...
March 28, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28348529/sport-specific-capacity-to-use-elastic-energy-in-the-patellar-and-achilles-tendons-of-elite-athletes
#14
Hans-Peter Wiesinger, Florian Rieder, Alexander Kösters, Erich Müller, Olivier R Seynnes
Introduction: During running and jumping activities, elastic energy is utilized to enhance muscle mechanical output and efficiency. However, training-induced variations in tendon spring-like properties remain under-investigated. The present work extends earlier findings on sport-specific profiles of tendon stiffness and cross-sectional area to examine whether years of distinct loading patterns are reflected by tendons' ability to store and return energy. Methods:Ultrasound scans were performed to examine the morphological features of knee extensor and plantar flexor muscle-tendon units in elite ski jumpers, distance runners, water polo players, and sedentary controls...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28339489/human-subtilisin-kexin-isozyme-1-ski-1-site-1-protease-s1p-regulates-cytoplasmic-lipid-droplet-abundance-a-potential-target-for-indirect-acting-anti-dengue-virus-agents
#15
Anastasia Hyrina, Fanrui Meng, Steven J McArthur, Sharlene Eivemark, Ivan R Nabi, François Jean
Viral hijacking and manipulation of host-cell biosynthetic pathways by human enveloped viruses are shared molecular events essential for the viral lifecycle. For Flaviviridae members such as hepatitis C virus and dengue virus (DENV), one of the key subsets of cellular pathways that undergo manipulation is the lipid metabolic pathways, underlining the importance of cellular lipids and, in particular, lipid droplets (LDs) in viral infection. Here, we hypothesize that targeting cellular enzymes that act as key regulators of lipid homeostasis and LD formation could represent a powerful approach to developing a novel class of broad-spectrum antivirals against infection associated with all DENV serotypes (1-4) circulating around the world...
2017: PloS One
https://www.readbyqxmd.com/read/28337944/the-influence-of-gate-start-position-on-physical-performance-and-anxiety-perception-in-expert-bmx-athletes
#16
Franck Di Rienzo, Guillaume Martinent, Lucie Levêque, Tadhg MacIntyre, Christian Collet, Aymeric Guillot
The critical importance of the start phase in bicycle motocross (BMX) racing is increasingly acknowledged. Past experiments underlined that the internal lane of the starting gate provides a strong positional advantage. However, how lane position affects start performance and cognitive and somatic state anxiety remains unexplored. We examined the start performance and anxiety responses of youth national-level BMX riders in both experimental and ecological contexts. We used contextualization motor imagery routines to evaluate start performance and state anxiety from the internal and external lanes...
March 24, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28336545/changes-in-intestinal-microbiota-composition-and-metabolism-coincide-with-increased-intestinal-permeability-in-young-adults-under-prolonged-physiologic-stress
#17
J Philip Karl, Lee M Margolis, Elisabeth H Madslien, Nancy E Murphy, John W Castellani, Yngvar Gundersen, Allison V Hoke, Michael W Levangie, Raina Kumar, Nabarun Chakraborty, Aarti Gautam, Rasha Hammamieh, Svein Martini, Scott J Montain, Stefan M Pasiakos
The magnitude, temporal dynamics, and physiologic effects of intestinal microbiome responses to physiologic stress are poorly characterized. This study used a systems biology approach and multiple-stressor military training environment to determine the effects of physiologic stress on intestinal microbiota composition and metabolic activity, and intestinal permeability (IP). 73 Soldiers were provided three rations/d with or without protein- or carbohydrate-based supplements during a four day cross-country ski march (STRESS)...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28333997/learning-better-by-repetition-or-variation-is-transfer-at-odds-with-task-specific-training
#18
Emmanuel Bonney, Lemke Dorothee Jelsma, Gillian D Ferguson, Bouwien C M Smits-Engelsman
OBJECTIVE: Transfer of motor skills is the ultimate goal of motor training in rehabilitation practice. In children with Developmental Coordination Disorder (DCD), very little is known about how skills are transferred from training situations to real life contexts. In this study we examined the influence of two types of practice on transfer of motor skills acquired in a virtual reality (VR) environment. METHOD: One hundred and eleven children with DCD and their typically developing (TD) peers, aged 6-10 years (M = 8...
2017: PloS One
https://www.readbyqxmd.com/read/28314090/prevalence-age-at-onset-and-risk-factors-of-self-reported-asthma-among-swedish-adolescent-elite-cross-country-skiers
#19
L M Eriksson, T Irewall, Anne Lindberg, Nikolai Stenfors
The objective of the study was to compare the prevalence of self-reported physician-diagnosed asthma and age at asthma onset between Swedish adolescent elite skiers and a reference group and to assess risk factors associated with asthma. Postal questionnaires were sent to 253 pupils at the Swedish National Elite Sport Schools for cross-country skiing, biathlon, and ski-orienteering ("skiers") and a random sample of 500 adolescents aged 16-20, matched for sport school municipalities ("reference"). The response rate was 96% among the skiers and 48% in the reference group...
March 17, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28298338/quality-of-care-in-performance-based-financing-how-it-is-incorporated-in-32-programs-across-28-countries
#20
REVIEW
Jessica Gergen, Erik Josephson, Martha Coe, Samantha Ski, Supriya Madhavan, Sebastian Bauhoff
OBJECTIVE: To describe how quality of care is incorporated into performance-based financing (PBF) programs, what quality indicators are being used, and how these indicators are measured and verified. METHODS: An exploratory scoping methodology was used to characterize the full range of quality components in 32 PBF programs, initiated between 2008 and 2015 in 28 low- and middle-income countries, totaling 68 quality tools and 8,490 quality indicators. The programs were identified through a review of the peer-reviewed and gray literature as well as through expert consultation with key donor representatives...
March 15, 2017: Global Health, Science and Practice
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