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https://www.readbyqxmd.com/read/29770187/primary-jejunal-burkitt-lymphoma-in-a-child-ultrasonic-detection
#1
Tatsuya Okamoto, Akane Sekiya, Tomoo Daifu, Ryuichiro Doi, Hisato Kobayashi
Gastrointestinal Burkitt lymphoma (BL) is a highly aggressive malignancy in childhood, and early treatment is critical for its favorable prognosis. Ultrasonography is a widely accepted initial imaging workup; therefore, recognition of the sonographic features of BL should contribute to its early diagnosis and initiation of treatment. We present a 4-year-old boy with primary jejunal BL with intussusception mimicking presentation, in which initial abdominal US allowed sustainable detection and characterization of the intestinal lesion...
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29760574/seasonal-variations-in-body-composition-maximal-oxygen-uptake-and-gas-exchange-threshold-in-cross-country-skiers
#2
Metin Polat, Selcen Korkmaz Eryılmaz, Sami Aydoğan
Introduction: In order to ensure that athletes achieve their highest performance levels during competitive seasons, monitoring their long-term performance data is crucial for understanding the impact of ongoing training programs and evaluating training strategies. The present study was thus designed to investigate the variations in body composition, maximal oxygen uptake (VO2max ), and gas exchange threshold values of cross-country skiers across training phases throughout a season. Materials and methods: In total, 15 athletes who participate in international cross-country ski competitions voluntarily took part in this study...
2018: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/29755656/single-walled-and-multi-walled-carbon-nanotubes-induce-sequence-specific-epigenetic-alterations-in-16-hbe-cells
#3
Manosij Ghosh, Deniz Öner, Radu C Duca, Bram Bekaert, Jeroen A J Vanoirbeek, Lode Godderis, Peter H M Hoet
Recent studies have identified carbon nanotube (CNT)-induced epigenetic changes as one of the key players in patho-physiological response. In the present study, we investigated whether CNT exposure is associated with epigenetic changes in human bronchial epithelial cells (16 HBE), in vitro . We focused on global DNA methylation, methylation of LINE-1 elements and promoter sequence of twelve functionally important genes ( SKI, DNMT1, HDAC4 , NPAT, ATM, BCL2L11, MAP3K10, PIK3R2, MYO1C, TCF3, FGFR 1 and AGRN )...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29735299/discontinuation-of-tyrosine-kinase-inhibitor-therapy-in-chronic-myeloid-leukaemia-euro-ski-a-prespecified-interim-analysis-of-a-prospective-multicentre-non-randomised-trial
#4
Susanne Saussele, Johan Richter, Joelle Guilhot, Franz X Gruber, Henrik Hjorth-Hansen, Antonio Almeida, Jeroen J W M Janssen, Jiri Mayer, Perttu Koskenvesa, Panayiotis Panayiotidis, Ulla Olsson-Strömberg, Joaquin Martinez-Lopez, Philippe Rousselot, Hanne Vestergaard, Hans Ehrencrona, Veli Kairisto, Katerina Machová Poláková, Martin C Müller, Satu Mustjoki, Marc G Berger, Alice Fabarius, Wolf-Karsten Hofmann, Andreas Hochhaus, Markus Pfirrmann, Francois-Xavier Mahon
BACKGROUND: Tyrosine kinase inhibitors (TKIs) have improved the survival of patients with chronic myeloid leukaemia. Many patients have deep molecular responses, a prerequisite for TKI therapy discontinuation. We aimed to define precise conditions for stopping treatment. METHODS: In this prospective, non-randomised trial, we enrolled patients with chronic myeloid leukaemia at 61 European centres in 11 countries. Eligible patients had chronic-phase chronic myeloid leukaemia, had received any TKI for at least 3 years (without treatment failure according to European LeukemiaNet [ELN] recommendations), and had a confirmed deep molecular response for at least 1 year...
May 4, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29734252/are-ski-and-snon-involved-in-the-tumorigenesis-of-oral-squamous-cell-carcinoma-through-smad4
#5
Mojgan Alaeddini, Shahroo Etemad-Moghadam
Transforming growth factor-β has been implicated in the tumorigenesis of oral squamous cell carcinoma (OSCC). Ski and SnoN are negative regulators of transforming growth factor-β/Smad pathway with both prooncogenic and antioncogenic functions in different cancers. The aim of this study was to assess the expression of Ski and SnoN in OSCC for the first time. Smad4 was also evaluated in these tumors. Clinical data on 61 primary OSCCs were gathered, and the specimens were subjected to immunohistochemical staining with monoclonal antibodies against SKI, SnoN, and Smad4 and scored semiquantitatively...
May 4, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29729772/safety-on-the-slopes-ski-versus-snowboard-injuries-in-children-treated-at-united-states-trauma-centers
#6
Stephanie F Polites, Shennen A Mao, Amy E Glasgow, Christopher R Moir, Elizabeth B Habermann
PURPOSE: Skiing and snowboarding are popular winter sports. The purpose of this study was to determine differences in injury patterns and severity between children participating in these sports treated at trauma centers in the United States. METHODS: Ski and snowboard injuries in children <15 identified from the 2011-2015 National Trauma Data Bank were compared using t tests, chi squared tests, and multivariable analyses. Time trends were evaluated using the Cochran Armitage trend test...
May 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29727925/effect-of-the-construction-of-ski-runs-on-changes-in-relief-in-a-mountain-catchment-inner-carpathians-southern-poland
#7
Joanna Fidelus-Orzechowska, Dominika Wrońska-Wałach, Jarosław Cebulski, Mirosław Żelazny
In the last decade increasing popularity of winter tourism in mountain areas in Poland influenced development of ski infrastructure. This type of human activity may induce changes in mountain relief. The purpose of the study was to quantify ongoing change patterns via: (i) a determination of spatial and quantitative changes in catchment covered by new ski runs, (ii) a determination of the effect of new ski runs on the rejuvenation of relief in valleys adjacent to ski runs, (iii) an identification of changes in the surface runoff pattern before and after the construction of ski runs...
July 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29721101/the-effect-of-aging-on-pacing-strategies-of-cross-country-skiers-and-the-role-of-performance-level
#8
Pantelis Theodoros Nikolaidis, Elias Villiger, Thomas Rosemann, Beat Knechtle
Background: The participation of master cross-country (XC) skiers in training and competition has increased during the last decades; however, little is known yet about whether these athletes differ from their younger counterparts in aspects of performance such as pacing. Therefore, the aim of the present study was to examine the combined effect of age and performance (race time) on pacing in cross-country (XC) skiing. We analyzed all finishers ( n  = 79,722) in 'Vasaloppet' from 2012 to 2017, the largest cross-country skiing race in the world, classified according to their race time into 10 groups: 3-4 h, 4-5 h, ...
2018: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/29718973/abrogation-of-transforming-growth-factor-%C3%AE-induced-tissue-fibrosis-in-tbricacol1a2cre-transgenic-mice-by-the-second-generation-tyrosine-kinase-inhibitor-ski-606-bosutinib
#9
Peter J Wermuth, Sergio A Jimenez
Transforming growth factor-β (TGF-β) plays a crucial role in the pathogenesis of Systemic Sclerosis (SSc) and other fibrotic disorders. TGF-β-mediated c-Abl and Src kinase activation induces strong profibrotic cascade signaling. The purpose of this study was to test in vivo the antifibrotic activity of Bosutinib (SKI-606), a second generation c-Abl and Src kinase inhibitor, on TGF-β induced cutaneous and pulmonary fibrosis. For this purpose, we employed the TBRIcaCol1a2Cre transgenic mice expressing an inducible constitutively active TGF-β receptor 1 constitutively activated by Col1a promoter-mediated Cre recombinase...
2018: PloS One
https://www.readbyqxmd.com/read/29718971/personal-social-and-environmental-factors-associated-with-lifejacket-wear-in-adults-and-children-a-systematic-literature-review
#10
Amy E Peden, Daniel Demant, Martin S Hagger, Kyra Hamilton
OBJECTIVE: Drowning claims 7% of the global burden of injury-related deaths. Lifejackets are routinely recommended as a drowning prevention strategy; however, a review of related factors regarding lifejacket wear has not previously been investigated. METHODS: This systematic review examined literature published from inception to December 2016 in English and German languages. The personal, social, and environmental factors associated with lifejacket wear among adults and children were investigated, a quantitative evaluation of the results undertaken, and gaps in the literature identified...
2018: PloS One
https://www.readbyqxmd.com/read/29709035/does-the-use-of-outdoor-fitness-equipment-by-older-adults-qualify-as-moderate-to-vigorous-physical-activity
#11
Hsueh-Wen Chow, Chia-Hua Ho
Despite the rapid worldwide expansion of parks with outdoor fitness equipment (OFE), no objective data regarding the intensity of activity associated with using OFE are available. Hence, this study quantified the energy expenditure and intensity of physical activity by examining four outdoor fitness devices widely used by older adults and provides objective evidence-based intensity references for the Compendium of Physical Activities. Sixteen older adults (mean age: 70.7 ± 5.6 yr) equipped with a portable metabolic system for measuring energy expenditure and activity intensity completed tasks while walking or using four types of OFE...
2018: PloS One
https://www.readbyqxmd.com/read/29708489/fmri-as-a-preimplant-objective-tool-to-predict-children-s-postimplant-auditory-and-language-outcomes-as-measured-by-parental-observations
#12
Aniruddha K Deshpande, Lirong Tan, Long J Lu, Mekibib Altaye, Scott K Holland
BACKGROUND: The trends in cochlear implantation candidacy and benefit have changed rapidly in the last two decades. It is now widely accepted that early implantation leads to better postimplant outcomes. Although some generalizations can be made about postimplant auditory and language performance, neural mechanisms need to be studied to predict individual prognosis. PURPOSE: The aim of this study was to use functional magnetic resonance imaging (fMRI) to identify preimplant neuroimaging biomarkers that predict children's postimplant auditory and language outcomes as measured by parental observation/reports...
May 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29700792/preventive-effect-of-shenkang-injection-against-high-glucose-induced-senescence-of-renal-tubular-cells
#13
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
Shenkang injection (SKI) is a classic prescription composed of Radix Astragali, rhubarb, Astragalus, Safflower, and Salvia. This treatment was approved by the State Food and Drug Administration of China in 1999 for treatment of chronic kidney diseases based on good efficacy and safety. This study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescence and its underlying mechanism. Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), medium containing 5 mmol/L glucose; (2) mannitol medium (mannitol group), medium containing 5 mmol/L glucose, and 25 mmol/L mannitol; (3) HG medium (HG group) containing 30 mmol/L glucose; (4) SKI treatment at high (200 mg/L), medium (100 mg/L), or low (50 mg/L) concentration in HG medium (HG + SKI group); or (5) 200 mg/L SKI treatment in control medium (control + SKI group) for 72 h...
April 25, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29698480/type-d-personality-stress-coping-and-performance-on-a-novel-sport-task
#14
Erika Borkoles, Mariana Kaiseler, Andrew Evans, Chantal F Ski, David R Thompson, Remco C J Polman
We investigated (1) the relationship between Type D personality, stress intensity appraisal of a self-selected stressor, coping, and perceived coping effectiveness and (2) the relationship between Type D personality and performance. In study one, 482 athletes completed the Type D personality questionnaire (DS14), stress thermometer and MCOPE in relation to a recently experienced sport stressor. Type D was associated with increased levels of perceived stress and selection of coping strategies (more emotion and avoidance coping) as well as perceptions of their effectiveness...
2018: PloS One
https://www.readbyqxmd.com/read/29697586/benefits-of-bimodal-hearing-with-cochlear-and-middle-ear-implants-preliminary-results-in-four-patients
#15
Hyun Jin Lee, Sung Huhn Kim, In Seok Moon, Jinsei Jung, Jeon Mi Lee, Jae Young Choi
OBJECTIVE: Conventional hearing aids have some limitations in overcoming a large air-bone gap or in cases of severe high-frequency hearing loss. The authors aimed to evaluate the benefit of a new bimodal hearing configuration combining cochlear implantation (CI) and middle ear implant (MEI) in patients with severe mixed conductive and ski-slope hearing loss. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Four patients with severe to profound hearing loss, who underwent CI in one ear and MEI in the other, were enrolled...
April 24, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29692376/sports-injury-related-fingers-and-thumb-deformity-due-to-tendon-or-ligament-rupture
#16
Rong-Jie Bai, Hui-Bo Zhang, Hui-Li Zhan, Zhan-Hua Qian, Nai-Li Wang, Yue Liu, Wen-Ting Li, Yu-Ming Yin
Background: Hand injuries are very common in sports, such as skiing and ball sports. One of the major reasons causing hand and finger deformity is due to ligament and tendon injury. The aim of this study was to investigate if the high-resolution 3T magnetic resonance imaging (MRI) can demonstrate the complex anatomy of the fingers and thumb, especially the tendons and ligaments, and provide the accurate diagnosis of clinically important fingers and thumbs deformity due to ligamentous and tendinous injuries during sport activities...
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29680335/the-sigmoid-notch-view-for-distal-radius-fractures
#17
Robin N Kamal, Fraser Leversedge, David S Ruch, Suhail K Mithani, Ilvy H F Cotterell, Marc J Richard
PURPOSE: This study defines the sigmoid notch view of the distal radius. Specifically, we tested the null hypothesis that there is no relationship between the subchondral stripe of bone seen on a sigmoid notch view of the distal radius and the articular surface of the sigmoid notch. METHODS: We used 44 wrist specimens for anatomic and fluoroscopic analysis. We measured the articular depth of the sigmoid notch from its deepest point and classified the shape of the sigmoid notch...
April 18, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29666157/cd30-expression-and-its-correlation-with-myc-and-bcl2-in-de-novo-diffuse-large-b-cell-lymphoma
#18
Qi-Xing Gong, Zhen Wang, Chong Liu, Xiao Li, Ting-Xun Lu, Jin-Hua Liang, Wei Xu, Jian-Yong Li, Zhi-Hong Zhang
AIM: CD30+ diffuse large B-cell lymphoma (DLBCL) has emerged as a new immunophenotypic variant of de novo DLBCLs. However, the prevalence of CD30 positivity is variable according to different studies, and the prognostic significance of CD30 is also controversial. This study aimed to investigate the positive expression rate and prognostic impact of CD30 in de novo DLBCLs and try to find the correlated influences. METHODS: A total of 241 patients with de novo DLBCL in east China from 2008 to 2015 were included to investigate the prevalence, clinicopathological features and outcomes of CD30+ de novo DLBCLs...
April 17, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29664803/posterior-shoulder-dislocation-associated-with-the-head-splitting-and-humeral-neck-fracture-impact-of-understanding-radiologic-signs-and-experience-with-an-extended-deltopectoral-approach
#19
Kemal Gokkus, Ergin Sagtas, Hasan Kara, Ahmet T Aydin
In this paper, our main objective was to emphasize the competency of extended deltopectoral exposure, enforced with the supraspinatus and subscapularis detachment, to gain access to the entire head. The second important point in this paper was to underline the importance of the knowledge that is necessary for interpreting classic radiologic signs of posterior fracture-dislocation of the shoulder. A 47-year-old woman fell down directly onto her shoulder while she was skiing. She was diagnosed with posterior shoulder dislocation, associated with fracture of the head (head splitting) and humeral neck fracture, with the aid of plain radiographs and computed tomographic results...
April 11, 2018: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/29663161/granulometric-and-pebble-morphometric-applications-to-benin-flank-sediments-in-western-anambra-basin-nigeria-proxies-for-paleoenvironmental-reconstruction
#20
Azuka Ocheli, Anthony Uwaoma Okoro, Ovie Benjamin Ogbe, Godwin Okumagbe Aigbadon
Integrated granulometric and pebble morphometric study of Late Cretaceous rocks of the Benin Flank, Nigeria, were used to delineate depositional process and environment of the rocks in the study area. Granulometric analysis reveals that the sandstones of the Lokoja Bassange Formation have an average graphic mean (Mz) of 0.59Φ (coarse grains), inclusive graphic standard deviation (δi) of 1.36Φ (poorly sorted), graphic kurtosis (Ka) of 1.12Φ (leptokurtic), and inclusive graphic skewness (Ski) of - 0.14Φ (stongly coarse skewed)...
April 17, 2018: Environmental Monitoring and Assessment
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