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https://www.readbyqxmd.com/read/28214335/the-role-of-c-ski-in-regulation-of-tgf%C3%AE-induced-human-cardiac-fibroblast-proliferation-and-ecm-protein-expression
#1
Juan Wang, Liping Guo, Difei Shen, Xiao Xu, Jiaping Wang, Suxia Han, Wen He
Cardiac fibrosis is characterized by over-deposition of extracellular matrix (ECM) proteins and over-proliferation of cardiac fibroblast, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. Transforming growth factor β 1 (TGFβ1) is as an essential inducing factor of cardiac fibrosis. C-Ski protein has been identified as an inhibitory regulator of TGFβ signaling. In the present study, we revealed the repressive effect of c-Ski on TGFβ1-induced human cardiac fibroblast (HCFB) proliferation and ECM protein increase (Collagen I and α-SMA)...
February 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28204585/a-short-splicing-isoform-of-hbs1l-links-the-cytoplasmic-exosome-and-ski-complexes-in-humans
#2
Katarzyna Kalisiak, Tomasz M Kuliński, Rafał Tomecki, Dominik Cysewski, Zbigniew Pietras, Aleksander Chlebowski, Katarzyna Kowalska, Andrzej Dziembowski
No abstract text is available yet for this article.
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28202374/walking-on-four-limbs-a-systematic-review-of-nordic-walking-in-parkinson-disease
#3
REVIEW
Federica Bombieri, Federico Schena, Barbara Pellegrini, Paolo Barone, Michele Tinazzi, Roberto Erro
Nordic Walking is a relatively high intensity activity that is becoming increasingly popular. It involves marching using poles adapted from cross-country skiing poles in order to activate upper body muscles that would not be used during normal walking. Several studies have been performed using this technique in Parkinson disease patients with contradictory results. Thus, we reviewed here all studies using this technique in Parkinson disease patients and further performed a meta-analysis of RCTs where Nordic Walking was evaluated against standard medical care or other types of physical exercise...
February 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28178740/-impact-of-the-overlap-region-between-acoustic-and-electric-stimulation
#4
Uwe Baumann, Moritz Mocka
Patients with residual hearing in the low frequencies and ski-slope hearing loss with partial deafness at medium and high frequencies receive a cochlear implant treatment with electric-acoustic stimulation (EAS, "hybrid" stimulation). In the border region between electric and acoustic stimulation a superposition of the 2 types of stimulation is expected. The area of overlap is determined by the insertion depth of the stimulating electrode and the lower starting point of signal transmission provided by the CI speech processor...
February 8, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28165392/sphingosine-kinase-1-involves-the-inhibitory-action-of-hif-1%C3%AE-by-chlorogenic-acid-in-hypoxic-du145-cells
#5
Myoung-Sun Lee, Seon-Ok Lee, Kyu-Ri Kim, Hyo-Jeong Lee
Hypoxia enhances cancer development in a solid tumor. Hypoxia-inducible factor-1 α (HIF-1α) is a transcription factor that is dominantly expressed under hypoxia in solid tumor cells and is a key factor that regulates tumor. HIF-1α regulates several target genes involved in many aspects of cancer progression, including angiogenesis, metastasis, anti-apoptosis and cell proliferation as well as imparts resistance to cancer treatment. In this study, we assessed Crataegus Pinnatifida Bunge var. typical Schneider ethanol extract (CPE) for its anti-cancer effects in hypoxia-induced DU145 human prostate cancer cell line...
February 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28162172/-radiographic-and-clinical-assessment-of-supracondylar-humeral-fractures-resulted-from-sports-in-children
#6
Z J Liu, S N Pan, L J Zhang
Objective: To investigate the radiographic and clinical assessment for supracondylar humeral fractures resulted from sports in children. Methods: The medical records of 166 patients with displaced supracondylar humerus fractures treated in Shengjing Hospital of China Medical University from January 2015 to December 2015 were reviewed.The etiology of 56 of 166 cases was relevant to the sports.Medical records of 56 of 166 patients were reviewed, incluidng gender, the mean age of patient at the time of surgery, the mean duration of injury, radiographic assessment based on the anteroposterior (AP) and lateral radiographs of the elbow, neurologic injury, the Mayo Elbow Performance Score (MEPS) and the criteria of Flynn...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28155748/-background-ln-the-current-context-of-increasing-numbers-of-children-living-with-a-chronic-disease-and-increasing-numbers-of-people-supervising-extracurricular-activities-difficulties-appear-to-persist-despite-the-personalised-core-project-pcp-this-study-explores
#7
Agnès Desserprix, Claire Marchand, Cyril Crozet
This study confirms the value of the PCP, but also the Jack of preparation of people supervising extracurricu/ar activ ities. lt highlights the need for training to allow these people to ensure the safety of chi /dren living with chronic diseases.</ce:para>.
October 19, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28155690/high-dimensional-omics-data-analysis-using-a-variable-screening-protocol-with-prior-knowledge-integration-ski
#8
Cong Liu, Jianping Jiang, Jianlei Gu, Zhangsheng Yu, Tao Wang, Hui Lu
BACKGROUND: High-throughput technology could generate thousands to millions biomarker measurements in one experiment. However, results from high throughput analysis are often barely reproducible due to small sample size. Different statistical methods have been proposed to tackle this "small n and large p" scenario, for example different datasets could be pooled or integrated together to provide an effective way to improve reproducibility. However, the raw data is either unavailable or hard to integrate due to different experimental conditions, thus there is an emerging need to develop a method for "knowledge integration" in high-throughput data analysis...
December 23, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28149223/successful-nerve-transfers-for-traumatic-brachial-plexus-palsy-in-a-septuagenarian-a-case-report
#9
Parker H Johnsen, Scott W Wolfe
Background: Conventional wisdom and the available literature demonstrate compromised outcomes following nerve reconstruction for traumatic brachial plexus palsy in the elderly. We present a 74-year-old male who was reconstructed with multiple nerve transfers for brachial plexus palsy after a ski accident. Methods: Triceps to axillary nerve transfer, spinal accessory to suprascapular nerve transfer, and ulnar to musculocutaneous nerve transfer were performed 16 weeks post injury. Results: At 11 years post-op, the patient could abduct to 65° and forward flex at M4 strength, limited only by painful glenohumeral arthritis...
December 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28141537/joint-inertial-sensor-orientation-drift-reduction-for-highly-dynamic-movements
#10
Benedikt Fasel, Jorg Sporri, Julien Chardonnens, Josef Kroll, Erich Muller, Kamiar Aminian
Inertial sensor drift is usually corrected on a single-sensor unit level. When multiple sensor units are used, mutual information from different units can be exploited for drift correction. This study introduces a method for a drift-reduced estimation of three dimensional (3D) segment orientations and joint angles for motion capture of highly dynamic movements as present in many sports. 3D acceleration measured on two adjacent segments is mapped to the connecting joint. Drift is estimated and reduced based on the mapped accelerations' vector orientation differences in the global frame...
January 26, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28133171/-gastric-cancer-diagnosed-with-metastasis-of-the-navel-sister-mary-joseph-s-nodule-a-case-report
#11
Tomohiro Katayama, Takaaki Ishii, Takeshi Tono, Yusuke Okubo, Koji Shinozaki, Yasuhito Kawasaki, Shuho Senba, Seiji Yasuda, Minoru Otsuru
A woman in her 60s was admitted to our hospital with pain and induration of the navel. She was diagnosed with gastric cancer with metastasis to the navel and underwent total gastrectomy and navel extraction. Because disseminated nodules were detected in the Douglas pouch and sigmoid colon, sigmoidectomy was performed to prevent bowel obstruction. The navel tumor was histologically diagnosed as a metastasis of the gastric cancer. One month after surgery, a chest skin tumor, which was also a skin metastasis of the gastric cancer[T4aN3M1(SKI, OTH)H0P1, fStage IV ], was detected, and tumor enucleation was performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28120046/music-and-mind-in-memoriam-professor-carlo-alberto-pagni-md-phd-february-13-1931-march-1-2009
#12
Klaus R H von Wild
Carlo Alberto Pagni, born in La Spezia, Italy, on February 13, 1931, was an eminent and respected professor of neurosurgery and chairman of the neurosurgical clinic of the University of Turin from 1980 to 2003. He died on March 1, 2009. As a professor of neurology and neurological surgery he was renowned as an expert on vascular, tumor, and functional neurosurgery. Beyond the Italian Neurosurgical Society, he was the doyen of functional neurosurgery, specializing in motor cortex stimulation for the treatment of focal dystonia, Parkinson's disease, and postictal spasticity and pain...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28118026/literature-review-on-risky-driving-videos-on-youtube-unknown-effects-and-areas-for-concern
#13
Evelyn Vingilis, Zümrüt Yıldırım-Yenier, Larissa Vingilis-Jaremko, Christine Wickens, Jane Seeley, Judy Fleiter, Daniel H Grushka
OBJECTIVE: Entry of terms reflective of extreme risky driving behaviours into the YouTube website yields millions of videos. The majority of the top 20 highly subscribed automotive YouTube websites are focused on high performance vehicles, high speed and often risky driving. Moreover, young men are the heaviest users of online video sharing sites, overall streaming more videos and watching them longer than any other group. The purpose of the paper is to review the literature on YouTube videos and risky driving...
January 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28115165/repression-of-smad3-by-stat3-and-c-ski-snon-induces-gefitinib-resistance-in-lung-adenocarcinoma
#14
Yojiro Makino, Jeong-Hwan Yoon, Eunjin Bae, Mitsuyasu Kato, Keiji Miyazawa, Tatsuo Ohira, Norihiko Ikeda, Masahiko Kuroda, Mizuko Mamura
Cancer-associated inflammation develops resistance to the epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) harboring oncogenic EGFR mutations. Stat3-mediated interleukin (IL)-6 signaling and Smad-mediated transforming growth factor-β (TGF-β) signaling pathways play crucial regulatory roles in cancer-associated inflammation. However, mechanisms how these pathways regulate sensitivity and resistance to EGFR-TKI in NSCLCs remain largely undetermined...
January 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28095083/physiological-capacity-and-training-routines-of-elite-cross-country-skiers-approaching-the-upper-limits-of-human-endurance
#15
Øyvind Sandbakk, Hans-Christer Holmberg
Cross-country skiing is one of the most demanding of endurance sports, involving protracted competitions on varying terrain employing a variety of skiing techniques that require upper- and/or lower-body work to different extents. Through more effective training and extensive improvements in equipment and track preparation, the speed of cross-country ski races has increased more than that of any other winter Olympic sport and, in addition, new types of racing events have been introduced. To a certain extent this has altered the optimal physiological capacity required to win and the training routines of successful skiers have evolved accordingly...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28095069/the-evolution-of-champion-cross-country-skier-training-from-lumberjacks-to-professional-athletes
#16
Øyvind Sandbakk
Competitive cross-country (XC) skiing has traditions extending back to the mid-19th century, and was included as a men's event in the first Winter Games in 1924. Since then, tremendous improvements in equipment, track preparation, and knowledge about training have prompted greater increases in XC skiing speeds than in any other Olympic sport. In response, this commentary focuses on how the training of successful XC skiers has evolved, with interviews and training data from surviving Norwegian world and Olympic XC champions as primary sources...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28076389/a-computational-study-on-the-relation-between-resting-heart-rate-and-atrial-fibrillation-hemodynamics-under-exercise
#17
Matteo Anselmino, Stefania Scarsoglio, Andrea Saglietto, Fiorenzo Gaita, Luca Ridolfi
AIMS: Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at investigating the impact of resting HR on the hemodynamic response to exercise in permanent AF patients by means of a computational cardiovascular model. METHODS: The AF lumped-parameter model was run to simulate resting (1 Metabolic Equivalent of Task-MET) and various exercise conditions (4 METs: brisk walking; 6 METs: skiing; 8 METs: running), considering different resting HR (70 bpm for the slower resting HR-SHR-simulations, and 100 bpm for the higher resting HR-HHR-simulations)...
2017: PloS One
https://www.readbyqxmd.com/read/28074775/axillary-artery-transection-and-bilateral-pulmonary-embolism-after-anterior-shoulder-dislocation-case-report
#18
Betty Leclerc, François Loisel, Maxime Ferrier, Mazen Al Sayed, Simon Rinckenbach, Laurent Obert
INTRODUCTION: Anterior shoulder dislocation can be associated with vascular and neurological complications. However, axillary artery injury associated with shoulder dislocation is rare and extremely rare without bone fracture. An early diagnosis of these complications allows predicting long-term functional outcomes. METHODS: This article reports the case of a 66-year-old patient who presented an anterior shoulder dislocation after a ski fall without any neurological dysfunction or pulse deficit...
2017: SICOT-J
https://www.readbyqxmd.com/read/28074067/expression-of-the-ctla-4-ligand-cd86-on-plasmacytoid-dendritic-cells-pdc-predicts-risk-of-disease-recurrence-after-treatment-discontinuation-in-cml
#19
C Schütz, S Inselmann, S Sausslele, C T Dietz, M C Mu Ller, E Eigendorff, C A Brendel, S K Metzelder, T H Bru Mmendorf, C Waller, J Dengler, M E Goebeler, R Herbst, G Freunek, S Hanzel, T Illmer, Y Wang, T Lange, F Finkernagel, R Hehlmann, M Huber, A Neubauer, A Hochhaus, J Guilhot, F Xavier Mahon, M Pfirrmann, A Burchert
It is unknown, why only a minority of chronic myeloid leukemia (CML) patients sustains treatment free remission (TFR) after discontinuation of tyrosine kinase inhibitor (TKI) therapy in deep molecular remission (MR). Here we studied, whether expression of the T-cell inhibitory receptor (CTLA-4)-ligand CD86 (B7.2) on plasmacytoid dendritic cells (pDC) affects relapse risk after TKI cessation. CML patients in MR displayed significantly higher CD86(+)pDC frequencies than normal donors (P<0.0024), whereas TFR patients had consistently low CD86(+)pDC (n=12)...
January 27, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28059863/spatiotemporal-expression-of-ski-after-rat-spinal-cord-injury
#20
Kaisheng Zhou, Wei Nan, Dongliang Feng, Zhigang Yi, Yandong Zhu, Zaiyun Long, Sen Li, Haihong Zhang, Yamin Wu
Ski is an evolutionarily conserved protein and widely participates in the regulation of various pathological and physiological processes such as wound healing, liver regeneration, development of the embryonic nervous system, muscle differentiation, and progression of many kinds of tumors. However, the distribution and function of Ski in central nervous system lesion and disease remain unclear. In this study, we investigated the spatiotemporal expression of Ski in a spinal cord injury (SCI) model in adult rats...
February 8, 2017: Neuroreport
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