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https://www.readbyqxmd.com/read/28339489/human-subtilisin-kexin-isozyme-1-ski-1-site-1-protease-s1p-regulates-cytoplasmic-lipid-droplet-abundance-a-potential-target-for-indirect-acting-anti-dengue-virus-agents
#1
Anastasia Hyrina, Fanrui Meng, Steven J McArthur, Sharlene Eivemark, Ivan R Nabi, François Jean
Viral hijacking and manipulation of host-cell biosynthetic pathways by human enveloped viruses are shared molecular events essential for the viral lifecycle. For Flaviviridae members such as hepatitis C virus and dengue virus (DENV), one of the key subsets of cellular pathways that undergo manipulation is the lipid metabolic pathways, underlining the importance of cellular lipids and, in particular, lipid droplets (LDs) in viral infection. Here, we hypothesize that targeting cellular enzymes that act as key regulators of lipid homeostasis and LD formation could represent a powerful approach to developing a novel class of broad-spectrum antivirals against infection associated with all DENV serotypes (1-4) circulating around the world...
2017: PloS One
https://www.readbyqxmd.com/read/28333997/learning-better-by-repetition-or-variation-is-transfer-at-odds-with-task-specific-training
#2
Emmanuel Bonney, Lemke Dorothee Jelsma, Gillian D Ferguson, Bouwien C M Smits-Engelsman
OBJECTIVE: Transfer of motor skills is the ultimate goal of motor training in rehabilitation practice. In children with Developmental Coordination Disorder (DCD), very little is known about how skills are transferred from training situations to real life contexts. In this study we examined the influence of two types of practice on transfer of motor skills acquired in a virtual reality (VR) environment. METHOD: One hundred and eleven children with DCD and their typically developing (TD) peers, aged 6-10 years (M = 8...
2017: PloS One
https://www.readbyqxmd.com/read/28314090/prevalence-age-at-onset-and-risk-factors-of-self-reported-asthma-among-swedish-adolescent-elite-cross-country-skiers
#3
L M Eriksson, T Irewall, Anne Lindberg, Nikolai Stenfors
The objective of the study was to compare the prevalence of self-reported physician-diagnosed asthma and age at asthma onset between Swedish adolescent elite skiers and a reference group and to assess risk factors associated with asthma. Postal questionnaires were sent to 253 pupils at the Swedish National Elite Sport Schools for cross-country skiing, biathlon, and ski-orienteering ("skiers") and a random sample of 500 adolescents aged 16-20, matched for sport school municipalities ("reference"). The response rate was 96% among the skiers and 48% in the reference group...
March 17, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28298338/quality-of-care-in-performance-based-financing-how-it-is-incorporated-in-32-programs-across-28-countries
#4
REVIEW
Jessica Gergen, Erik Josephson, Martha Coe, Samantha Ski, Supriya Madhavan, Sebastian Bauhoff
OBJECTIVE: To describe how quality of care is incorporated into performance-based financing (PBF) programs, what quality indicators are being used, and how these indicators are measured and verified. METHODS: An exploratory scoping methodology was used to characterize the full range of quality components in 32 PBF programs, initiated between 2008 and 2015 in 28 low- and middle-income countries, totaling 68 quality tools and 8,490 quality indicators. The programs were identified through a review of the peer-reviewed and gray literature as well as through expert consultation with key donor representatives...
March 15, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28291666/risk-and-protective-factors-for-sudden-cardiac-death-during-leisure-activities-in-the-mountains-an-update
#5
REVIEW
Martin Burtscher
INTRODUCTION: Annually, more than 100 million tourists with widely varying health and fitness status are attracted by the mountainous areas around the world. Whereas mountaineering activities may contribute to the well established beneficial effects of regular exercise, for certain individuals these activities are also associated with a relatively high risk of death. METHODS: This manuscript presents an updated overview of risk and protective factors for sudden cardiac death during leisure activities in the mountains...
February 28, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28287028/technique-analysis-in-elite-athletes-using-principal-component-analysis
#6
Øyvind Gløersen, Håvard Myklebust, Jostein Hallén, Peter Federolf
The aim of this study was to advance current movement analysis methodology to enable a technique analysis in sports facilitating (1) concurrent comparison of the techniques between several athletes; (2) identification of potentially beneficial technique modifications and (3) a visual representation of the findings for feedback to the athletes. Six elite cross-country skiers, three world cup winners and three national elite, roller ski skated using the V2 technique on a treadmill while their movement patterns were recorded using 41 reflective markers...
March 13, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28274967/effect-of-using-cardiovascular-risk-scoring-in-routine-risk-assessment-in-primary-prevention-of-cardiovascular-disease-protocol-for-an-overview-of-systematic-reviews
#7
Krzysztof Studzin Ski, Tomasz Tomasik, Janusz Krzyszton, Jacek Józ Wiak, Adam Windak
INTRODUCTION: Major clinical practice guidelines recommend assessing risk of cardiovascular disease (CVD) using absolute/global/total CVD risk scores. However, the effectiveness of using them in clinical practice, despite publication of numerous randomised controlled trials (RCTs), is still poorly understood. To summarise and analyse current knowledge in this field, we will carry out an overview of existing systematic reviews (SRs). The objective of this overview will be to assess the effect of using cardiovascular risk scoring in routine risk assessment in primary prevention of CVD compared with standard care...
March 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28271769/watch-out-for-the-impatient-patient
#8
Jane Bates
'How long will we be, nurse?' This is the question that sends my spirits downhill faster than a mountain bike on skis.
March 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28270769/the-role-of-power-fluctuations-in-the-preference-of-diagonal-vs-double-poling-sub-technique-at-different-incline-speed-combinations-in-elite-cross-country-skiers
#9
Christine Dahl, Øyvind Sandbakk, Jørgen Danielsen, Gertjan Ettema
In classical cross-country skiing, diagonal stride (DIA) is the major uphill sub-technique, while double poling (DP) is used on relatively flat terrain. Although, the dependence of incline and speed on the preference of either sub-technique seems clearly established, the mechanisms behind these preferences are not clear. Therefore, the purpose of this study was to compare kinetics and energy consumption in DP and DIA at the same submaximal workload in cross-country skiing under two different incline-speed combinations...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28254746/what-strategies-can-be-used-to-effectively-reduce-the-risk-of-concussion-in-sport
#10
REVIEW
Carolyn A Emery, Amanda M Black, Ash Kolstad, German Martinez, Alberto Nettel-Aguirre, Lars Engebretsen, Karen Johnston, James Kissick, David Maddocks, Charles Tator, Mark Aubry, Jiří Dvorák, Shinji Nagahiro, Kathryn Schneider
AIM OR OBJECTIVE: To examine the effectiveness of concussion prevention strategies in reducing concussion risk in sport. DESIGN: Systematic review according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. DATA SOURCES: Eleven electronic databases searched and hand-search of references from selected studies. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: The following were the study inclusion criteria: (1) contained original human research data; (2) investigated an outcome of concussion or head impact; (3) evaluated a concussion prevention intervention; (4) included sport participants; (5) analytical study designand (6) peer-reviewed...
March 2, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28241030/effects-of-upper-body-sprint-interval-training-on-strength-and-endurance-capacities-in-female-cross-country-skiers
#11
Kristine Vandbakk, Boye Welde, Andrea Hovstein Kruken, Julia Baumgart, Gertjan Ettema, Trine Karlsen, Øyvind Sandbakk
This study compared the effects of adding upper-body sprint-intervals or continuous double poling endurance training to the normal training on maximal upper-body strength and endurance capacity in female cross-country skiers. In total, 17 female skiers (age: 18.1±0.8yr, body mass: 60±7 kg, maximal oxygen uptake (VO2max): 3.30±0.37 L.min-1) performed an 8-week training intervention. Here, either two weekly sessions of six to eight 30-s maximal upper-body double poling sprint-intervals (SIG, n = 8) or 45-75 min of continuous low-to-moderate intensity double poling on roller skis (CG, n = 9) were added to their training...
2017: PloS One
https://www.readbyqxmd.com/read/28225644/a-narrative-synthesis-of-nintendo-wii-fit-gaming-protocol-in-addressing-balance-among-healthy-older-adults-what-system-works
#12
Donald G Manlapaz, Gisela Sole, Prasath Jayakaran, Cathy M Chapple
BACKGROUND: Balance is crucial in performing functional tasks particularly among older adults. Exergaming is gaining attention as a novel approach to enhance balance in a number of clinical populations. OBJECTIVES: The aim of this review was to synthesize and present published evidence for Nintendo Wii Fit™ gaming system protocols. These include game preference, intervention setting, and exercise dosage for improving balance in healthy older adults. Commonly used outcome measures were also identified...
February 22, 2017: Games for Health
https://www.readbyqxmd.com/read/28223309/how-can-we-prove-that-a-preventive-measure-in-elite-sport-is-effective-when-the-prevalence-of-the-injury-eg-acl-tear-in-alpine-ski-racing-is-low-a-case-for-surrogate-outcomes
#13
EDITORIAL
Josef Kröll, Jörg Spörri, Sophie Elspeth Steenstrup, Hermann Schwameder, Erich Müller, Roald Bahr
No abstract text is available yet for this article.
February 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28219091/-patrouille-des-glaciers-analysis-of-course-times
#14
Benedikt Andreas Gasser
Background Backcountry skiing has become more and more popular. The development of skis and equipment has been impressive and suggests that achieving a good performance level is much easier today than it was in the past. Taking the most popular backcountry skiing race in Switzerland, the "Patrouille des Glaciers (PDG)", we addressed the question as to whether this development has led to faster course times over the past ten years and what recommendations can be made for participants. Methods The average course times for the original course Zermatt - Arolla - Verbier were calculated over the past ten years for two cohorts (top-ten and median), separated by category...
February 20, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28214335/the-role-of-c-ski-in-regulation-of-tgf%C3%AE-induced-human-cardiac-fibroblast-proliferation-and-ecm-protein-expression
#15
Juan Wang, Liping Guo, Difei Shen, Xiao Xu, Jiaping Wang, Suxia Han, Wen He
Cardiac fibrosis is characterized by over-deposition of extracellular matrix (ECM) proteins and over-proliferation of cardiac fibroblast, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. Transforming growth factor β 1 (TGFβ1) is as an essential inducing factor of cardiac fibrosis. C-Ski protein has been identified as an inhibitory regulator of TGFβ signaling. In the present study, we revealed the repressive effect of c-Ski on TGFβ1-induced human cardiac fibroblast (HCFB) proliferation and ECM protein increase (Collagen I and α-SMA)...
February 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28204585/a-short-splicing-isoform-of-hbs1l-links-the-cytoplasmic-exosome-and-ski-complexes-in-humans
#16
Katarzyna Kalisiak, Tomasz M Kuliński, Rafał Tomecki, Dominik Cysewski, Zbigniew Pietras, Aleksander Chlebowski, Katarzyna Kowalska, Andrzej Dziembowski
No abstract text is available yet for this article.
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28202374/walking-on-four-limbs-a-systematic-review-of-nordic-walking-in-parkinson-disease
#17
REVIEW
Federica Bombieri, Federico Schena, Barbara Pellegrini, Paolo Barone, Michele Tinazzi, Roberto Erro
Nordic Walking is a relatively high intensity activity that is becoming increasingly popular. It involves marching using poles adapted from cross-country skiing poles in order to activate upper body muscles that would not be used during normal walking. Several studies have been performed using this technique in Parkinson disease patients with contradictory results. Thus, we reviewed here all studies using this technique in Parkinson disease patients and further performed a meta-analysis of RCTs where Nordic Walking was evaluated against standard medical care or other types of physical exercise...
February 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28178740/-impact-of-the-overlap-region-between-acoustic-and-electric-stimulation
#18
Uwe Baumann, Moritz Mocka
Patients with residual hearing in the low frequencies and ski-slope hearing loss with partial deafness at medium and high frequencies receive a cochlear implant treatment with electric-acoustic stimulation (EAS, "hybrid" stimulation). In the border region between electric and acoustic stimulation a superposition of the 2 types of stimulation is expected. The area of overlap is determined by the insertion depth of the stimulating electrode and the lower starting point of signal transmission provided by the CI speech processor...
February 8, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28165392/sphingosine-kinase-1-involves-the-inhibitory-action-of-hif-1%C3%AE-by-chlorogenic-acid-in-hypoxic-du145-cells
#19
Myoung-Sun Lee, Seon-Ok Lee, Kyu-Ri Kim, Hyo-Jeong Lee
Hypoxia enhances cancer development in a solid tumor. Hypoxia-inducible factor-1 α (HIF-1α) is a transcription factor that is dominantly expressed under hypoxia in solid tumor cells and is a key factor that regulates tumor. HIF-1α regulates several target genes involved in many aspects of cancer progression, including angiogenesis, metastasis, anti-apoptosis and cell proliferation as well as imparts resistance to cancer treatment. In this study, we assessed Crataegus Pinnatifida Bunge var. typical Schneider ethanol extract (CPE) for its anti-cancer effects in hypoxia-induced DU145 human prostate cancer cell line...
February 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28162172/-radiographic-and-clinical-assessment-of-supracondylar-humeral-fractures-resulted-from-sports-in-children
#20
Z J Liu, S N Pan, L J Zhang
Objective: To investigate the radiographic and clinical assessment for supracondylar humeral fractures resulted from sports in children. Methods: The medical records of 166 patients with displaced supracondylar humerus fractures treated in Shengjing Hospital of China Medical University from January 2015 to December 2015 were reviewed.The etiology of 56 of 166 cases was relevant to the sports.Medical records of 56 of 166 patients were reviewed, incluidng gender, the mean age of patient at the time of surgery, the mean duration of injury, radiographic assessment based on the anteroposterior (AP) and lateral radiographs of the elbow, neurologic injury, the Mayo Elbow Performance Score (MEPS) and the criteria of Flynn...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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