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https://www.readbyqxmd.com/read/28929659/-effects-and-mechanisms-of-shenkang-injection-promoting-extracellular-matrix-degradation-via-regulating-erk1-2-mmps-signaling-pathway-in-renal-failure-rats
#1
Jing-Jing Yang, Zhi-Min Mao, Yi-Gang Wan, Wei Wu, Yan-Ru Huang, Ge Shi, Wen-Bei Han, Jian Yao
This study aimed to clarify preliminarily the effects and mechanisms of Shenkang injection (SKI) promoting extracellular matrix(ECM)degradation via regulating extracellular-signal regulated protein kinase(ERK)1/2/matrix metalloproteinases(MMPs)signaling pathway in renal failure rats. Twenty rats were randomly divided into 4 groups:the Sham group,the Model group,the SKI group and the Enalapril maleate(EM)group. The model rats with renal failure were induced by intragastric administration of adenine and unilateral ureteral obstruction(UUO)...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28921697/cross-country-skiing-is-associated-with-lower-all-cause-mortality-a-population-based-follow-up-study
#2
Jari A Laukkanen, Tanjaniina Laukkanen, Setor K Kunutsor
OBJECTIVES: The prospective relationship between leisure time cross-country skiing and any fatal events is uncertain. We aimed to assess the associations of leisure time cross-country skiing habits with the risk of all-cause mortality in a general population. METHODS: A 12-month physical activity questionnaire was used at baseline to assess the frequency, average duration, and intensity of cross-country skiing in a prospective population-based cohort of 2,087 middle-aged men from Eastern Finland...
September 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28912731/long-term-athletic-development-in-youth-alpine-ski-racing-the-effect-of-physical-fitness-ski-racing-technique-anthropometrics-and-biological-maturity-status-on-injuries
#3
Lisa Müller, Carolin Hildebrandt, Erich Müller, Christian Fink, Christian Raschner
Alpine ski racing is known to be a sport with a high risk of injuries. Because most studies have focused mainly on top-level athletes and on traumatic injuries, limited research exists about injury risk factors among youth ski racers. The aim of this study was to determine the intrinsic risk factors (anthropometrics, biological maturity, physical fitness, racing technique) for injury among youth alpine ski racers. Study participants were 81 youth ski racers attending a ski boarding school (50 males, 31 females; 9-14 years)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28912656/do-maximal-roller-skiing-speed-and-double-poling-performance-predict-youth-cross-country-skiing-performance
#4
Roland Stöggl, Erich Müller, Thomas Stöggl
The aims of the current study were to analyze whether specific roller skiing tests and cycle length are determinants of youth cross-country (XC) skiing performance, and to evaluate sex specific differences by applying non-invasive diagnostics. Forty-nine young XC skiers (33 boys; 13.8 ± 0.6 yrs and 16 girls; 13.4 ± 0.9 yrs) performed roller skiing tests consisting of both shorter (50 m) and longer durations (575 m). Test results were correlated with on snow XC skiing performance (PXC) based on 3 skating and 3 classical distance competitions (3 to 6 km)...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28905115/clinical-application-of-snp-array-analysis-in-fetuses-with-ventricular-septal-defects-and-normal-karyotypes
#5
Fang Fu, Qiong Deng, Ting-Ying Lei, Ru Li, Xiang-Yi Jing, Xin Yang, Can Liao
PURPOSE: The present study aims to evaluate the utility of high-resolution single-nucleotide polymorphism (SNP) arrays in fetuses with ventricular septal defects (VSDs) with or without other structural anomalies but with normal karyotypes and to investigate the outcomes of cases of prenatal VSDs via clinical follow-up. METHODS: We analyzed 144 fetuses with VSDs and normal karyotypes using Affymetrix CytoScan HD arrays and the analyses were carried out a year after birth...
September 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28904979/the-russians-are-the-fastest-in-marathon-cross-country-skiing-the-engadin-ski-marathon
#6
Pantelis Theodoros Nikolaidis, Jan Heller, Beat Knechtle
It is well known that athletes from a specific region or country are dominating certain sports disciplines such as marathon running or Ironman triathlon; however, little relevant information exists on cross-country skiing. Therefore, the aim of the present study was to investigate the aspect of region and nationality in one of the largest cross-country skiing marathons in Europe, the "Engadin Ski Marathon." All athletes (n = 197,125) who finished the "Engadin Ski Marathon" between 1998 and 2016 were considered...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28901201/sex-differences-in-balance-among-alpine-ski-racers-cross-sectional-age-comparisons
#7
Christian Raschner, Carolin Hildebrandt, Johanna Mohr, Lisa Müller
Although balance is a key ability in the strength demands of alpine ski racing, affecting both performance and injury prevention, few studies have examined balance or related sex differences among still-maturing athletes. In this 10-year study, we investigated cross-sectional balance performances at different age periods of a representative sample of over 500 11-18-year-old elite skiers of both genders. Participants performed balance tests using the MFT S3-Check. Left-right and forward-backward movements were used to calculate sensory and symmetry balance scores, which were both incorporated into a stability score...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28899914/military-training-elicits-marked-increases-in-plasma-metabolomic-signatures-of-energy-metabolism-lipolysis-fatty-acid-oxidation-and-ketogenesis
#8
J Philip Karl, Lee M Margolis, Nancy E Murphy, Christopher T Carrigan, John W Castellani, Elisabeth H Madslien, Hilde-Kristin Teien, Svein Martini, Scott J Montain, Stefan M Pasiakos
Military training studies provide unique insight into metabolic responses to extreme physiologic stress induced by multiple stressor environments, and the impacts of nutrition in mediating these responses. Advances in metabolomics have provided new approaches for extending current understanding of factors modulating dynamic metabolic responses in these environments. In this study, whole-body metabolic responses to strenuous military training were explored in relation to energy balance and macronutrient intake by performing nontargeted global metabolite profiling on plasma collected from 25 male soldiers before and after completing a 4-day, 51-km cross-country ski march that produced high total daily energy expenditures (25...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28894440/otitis-media-caused-by-v-cholerae-o100-a-case-report-and-review-of-the-literature
#9
Peter Kechker, Yigal Senderovich, Shifra Ken-Dror, Sivan Laviad-Shitrit, Eiji Arakawa, Malka Halpern
Infections due to Vibrio cholerae are rarely documented in Israel. Here we report a case of recurrent otitis media in a young male, caused by V. cholerae non-O1/O139. This extra-intestinal infection was caused by V. cholerae O100 and has been associated with freshwater exposure and travel. Symptoms of chronic periodic earaches along with purulent exudate began about one week after the patient suffered a water skiing accident on a river in Australia. The condition lasted for three years, until his ear exudate was examined in a clinical laboratory, diagnosed and treated...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28893254/skip-controls-flowering-time-via-the-alternative-splicing-of-sef-pre-mrna-in-arabidopsis
#10
Zhibo Cui, Aizi Tong, Yiqiong Huo, Zhiqiang Yan, Weiqi Yang, Xianli Yang, Xiao-Xue Wang
BACKGROUND: Similar to other eukaryotes, splicing is emerging as an important process affecting development and stress tolerance in plants. Ski-interacting protein (SKIP), a splicing factor, is essential for circadian clock function and abiotic stress tolerance; however, the mechanisms whereby it regulates flowering time are unknown. RESULTS: In this study, we found that SKIP is required for the splicing of serrated leaves and early flowering (SEF) pre-messenger RNA (mRNA), which encodes a component of the ATP-dependent SWR1 chromatin remodeling complex (SWR1-C)...
September 11, 2017: BMC Biology
https://www.readbyqxmd.com/read/28890935/ski-178-a-multitargeted-inhibitor-of-sphingosine-kinase-and-microtubule-dynamics-demonstrating-therapeutic-efficacy-in-acute-myeloid-leukemia-models
#11
Jeremy A Hengst, Taryn E Dick, Arati Sharma, Kenichiro Doi, Shailaja Hegde, Su-Fern Tan, Laura M Geffert, Todd E Fox, Arun K Sharma, Dhimant Desai, Shantu Amin, Mark Kester, Thomas P Loughran, Robert F Paulson, David F Claxton, Hong-Gang Wang, Jong K Yun
AIM: To further characterize the selectivity, mechanism-of-action and therapeutic efficacy of the novel small molecule inhibitor, SKI-178. METHODS: Using the state-of-the-art Cellular Thermal Shift Assay (CETSA) technique to detect "direct target engagement" of proteins intact cells, in vitro and in vivo assays, pharmacological assays and multiple mouse models of acute myeloid leukemia (AML). RESULTS: Herein, we demonstrate that SKI-178 directly target engages both Sphingosine Kinase 1 and 2...
July 2017: Cancer Translational Medicine
https://www.readbyqxmd.com/read/28878888/cardiovascular-and-thermal-strain-during-3-4%C3%A2-days-of-a-metabolically-demanding-cold-weather-military-operation
#12
John W Castellani, Marissa G Spitz, Anthony J Karis, Svein Martini, Andrew J Young, Lee M Margolis, J Phillip Karl, Nancy E Murphy, Xiaojiang Xu, Scott J Montain, Jamie A Bohn, Hilde K Teien, Pål H Stenberg, Yngvar Gundersen, Stefan M Pasiakos
BACKGROUND: Cardiovascular (CV) and thermal responses to metabolically demanding multi-day military operations in extreme cold-weather environments are not well described. Characterization of these operations will provide greater insights into possible performance capabilities and cold injury risk. METHODS: Soldiers from two cold-weather field training exercises (FTX) were studied during 3-day (study 1, n = 18, age: 20 ± 1 year, height: 182 ± 7 cm, mass: 82 ± 9 kg) and 4-day (study 2, n = 10, age: 20 ± 1 year, height: 182 ± 6 cm, mass: 80...
2017: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/28863392/mindfulness-mediates-the-physiological-markers-of-stress-systematic-review-and-meta-analysis
#13
Michaela C Pascoe, David R Thompson, Zoe M Jenkins, Chantal F Ski
Meditation is a popular form of stress management, argued to mediate stress reactivity. However, many studies in this field commonly fail to include an active control group. Given the frequency with which people are selecting meditation as a form of self-management, it is important to validate if the practice is effective in mediating stress-reactivity using well-controlled studies. Thus, we aimed to conduct a meta-analysis investigating the neurobiological effects of meditation, including focused attention, open monitoring and automatic self-transcending subtypes, compared to an active control, on markers of stress...
August 23, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28860339/treatment-outcome-in-a-population-based-real-world-cohort-of-chronic-myeloid-leukemia-patients
#14
Inge G P Geelen, Noortje Thielen, Jeroen J W M Janssen, Mels Hoogendoorn, Tanja J A Roosma, Sten P Willemsen, Otto Visser, Jan J Cornelissen, Peter E Westerweel
Real-world evaluations of the efficacy and safety of tyrosine kinase inhibitors in patients with chronic myeloid leukemia are scarce. A nationwide population-based chronic myeloid leukemia registry was analyzed to evaluate (deep) response rates to first and subsequent treatment lines and eligibility for a treatment cessation attempt in adults diagnosed between January 2008 and April 2013 in the Netherlands. The registries covered 457 patients; 434 in chronic (95%) and 15 patients (3%) in advanced disease phase...
August 31, 2017: Haematologica
https://www.readbyqxmd.com/read/28855239/closed-loop-control-during-intense-prolonged-outdoor-exercise-in-adolescents-with-type-1-diabetes-the-artificial-pancreas-ski-study
#15
Marc D Breton, Daniel R Cherñavvsky, Gregory P Forlenza, Mark D DeBoer, Jessica Robic, R Paul Wadwa, Laurel H Messer, Boris P Kovatchev, David M Maahs
OBJECTIVE: Intense exercise is a major challenge to the management of type 1 diabetes (T1D). Closed loop control (CLC) systems (artificial pancreas) improve glycemic control during limited intensity and short duration of physical activity (PA). However, CLC has not been tested during extended vigorous outdoor exercise common among adolescents. RESEARCH DESIGN AND METHODS: Skiing presents unique metabolic challenges: intense prolonged PA, cold, altitude, and stress/fear/excitement...
August 30, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28846855/expert-non-expert-differences-in-visual-behaviour-during-alpine-slalom-skiing
#16
Marjolein Decroix, Mohd Rozilee Wazir Norjali Wazir, Linus Zeuwts, Frederik F J A Deconinck, Matthieu Lenoir, Pieter Vansteenkiste
The aim of this study was to investigate visual behaviour of expert and non-expert ski athletes during an alpine slalom. Fourteen non-experts and five expert slalom skiers completed an alpine slalom course in an indoor ski slope while wearing a head-mounted eye tracking device. Experts completed the slalom clearly faster than non-experts, but no significant difference was found in timing and position of the turn initiation. Although both groups already looked at future obstacles approximately 0,5s before passing the upcoming pole, the higher speed of experts implied that they shifted gaze spatially earlier in the bend than non-experts...
August 25, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28844002/expression-of-ski-and-its-role-in-astrocyte-proliferation-and-migration
#17
X Zhao, X-W Wang, K-S Zhou, W Nan, Y-Q Guo, J-L Kou, J Wang, Y-Y Xia, H-H Zhang
Ski, as an evolutionarily conserved protein, is a versatile transcriptional regulator which widely distributes in various tissues and species. Recently, we have demonstrated for the first time that Ski was strikingly up-regulated in reactive astrocytes after spinal cord injury (SCI) in vivo, which indicates that maybe Ski is a new molecule that controls astrocytes' biological properties after SCI. However, the accurate distributions and functions of Ski in astrocytes after central nervous system (CNS) injury are still unclear...
August 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28827198/survival-of-cardiac-arrest-patients-on-ski-slopes-a-10-year-analysis-of-the-northern-french-alps-emergency-network
#18
Damien Viglino, Maxime Maignan, Arnaud Michalon, Julien Turk, Sarah K Buse, Marc Blancher, Tom P Aufderheide, Loïc Belle, Dominique Savary, François-Xavier Ageron, Guillaume Debaty
AIM: Intense physical activity, cold and altitude make mountain sports a cause of increased risk of out-of-hospital cardiac arrest (OHCA). The difficulties of pre-hospital management related to this challenging environment could be mitigated by the presence of ski-patrollers in ski areas and use of helicopters for medical rescue. We assess whether this particular situation positively impacts the chain of survival compared to the general population. METHODS: Analysis of prospectively collected data from the cardiac arrest registry of the Northern French Alps Emergency Network (RENAU) from 2004 to 2014...
August 4, 2017: Resuscitation
https://www.readbyqxmd.com/read/28821900/erratum-to-sitting-position-affects-performance-in-cross-country-sit-skiing
#19
M Lund Ohlsson, M S Laaksonen
No abstract text is available yet for this article.
August 19, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28812037/a-retrospective-analysis-of-concurrent-pathology-in-acl-reconstructed-knees-of-elite-alpine-ski-racers
#20
Matthew J Jordan, Patricia Doyle-Baker, Mark Heard, Per Aagaard, Walter Herzog
BACKGROUND: Anterior cruciate ligament (ACL) tear is the most frequent injury in alpine ski racing, and there is a high prevalence of ACL reinjury. Limited data exist on the concurrent pathology with primary ACL tears in elite alpine ski racers and the magnitude of injury progression after primary ACL reconstruction (ACLR). PURPOSE: To evaluate (1) the involvement of intra-articular and multiligament pathologies at the time of primary ACLR, (2) the subsequent progression in meniscal/chondral injuries, and (3) the occurrence of ACL reinjury in elite alpine ski racers...
July 2017: Orthopaedic Journal of Sports Medicine
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