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https://www.readbyqxmd.com/read/28745084/patient-with-unresectable-cholangiocarcinoma-treated-with-radiofrequency-hyperthermia-in-combination-with-chemotherapy-a-case-report
#1
Juyoung Ryu, Kangwook Lee, Changmug Joe, JongCheon Joo, Namhun Lee, Hwa-Seung Yoo
Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy...
July 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28718257/risk-factors-for-heat-related-deaths-during-the-june-2015-heat-wave-in-karachi-pakistan
#2
Syed Ghazanfar Saleem, Tehreem Ansari, Ashraf Shamshad Ali, Sara Fatima, Mariam Hassan Rizvi, Muhammad Abdul Samad
BACKGROUND: Mortality as a consequence of heat related illness is a public health concern. Emergency department (ED) experiences increased patients' flow and decreased survival as a consequence of heat stroke during the episodes of heat wave. The present study was conducted to identify the risk factors for mortality among victims of heat wave (17th - 23rd June), 2015 evaluated in the Emergency Department of The Indus Hospital (TIH), Karachi. METHODS: In this cross-sectional study data was retrospectively collected...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28708081/modeling-the-effects-of-urban-design-on-emergency-medical-response-calls-during-extreme-heat-events-in-toronto-canada
#3
Drew A Graham, Jennifer K Vanos, Natasha A Kenny, Robert D Brown
Urban residents are at risk of health-related illness during extreme heat events but the dangers are not equal in all parts of a city. Previous studies have found a relationship between physical characteristics of neighborhoods and the number of emergency medical response (EMR) calls. We used a human energy budget model to test the effects of landscape modifications that are designed to cool the environment on the expected number of EMR calls in two neighborhoods in Toronto, Canada during extreme heat events...
July 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28700537/qst-response-patterns-to-capsaicin-and-uv-b-induced-local-skin-hypersensitization-in-healthy-subjects-a-machine-learned-analysis
#4
Jörn Lötsch, Gerd Geisslinger, Sarah Heinemann, Florian Lerch, Bruno G Oertel, Alfred Ultsch
The comprehensive assessment of pain-related human phenotypes requires combinations of nociceptive measures that produce complex high-dimensional data, posing challenges to bioinformatic analysis. In this study, we assessed established experimental models of heat hyperalgesia of the skin, consisting of local ultraviolet-B (UV-B) irradiation or capsaicin application, in 82 healthy subjects using a variety of noxious stimuli. We extended the original heat simulation by applying cold and mechanical stimuli and assessing the hypersensitization effects with a clinically established quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain)...
July 8, 2017: Pain
https://www.readbyqxmd.com/read/28696476/on-the-origin-of-the-driving-force-in-the-marangoni-propelled-gas-bubble-trapping-mechanism
#5
A Miniewicz, C Quintard, H Orlikowska, S Bartkiewicz
Gas bubbles can be trapped and then manipulated with laser light. In this report, we propose the detailed optical trapping mechanism of gas bubbles confined inside a thin light-absorbing liquid layer between two glass plates. The necessary condition of bubble trapping in this case is the direct absorption of light by the solution containing a dye. Due to heat release, fluid whirls propelled by the surface Marangoni effect at the liquid/gas interface emerge and extend to large distances. We report the experimental microscopic observation of the origin of whirls at an initially flat liquid/air interface as well as at the curved interface of a liquid/gas bubble and support this finding with advanced numerical simulations using the finite element method within the COMSOL Multiphysics platform...
July 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28692392/evaluation-of-a-novel-syndromic-surveillance-query-for-heat-related-illness-using-hospital-data-from-maricopa-county-arizona-2015
#6
Jessica R White, Vjollca Berisha, Kathryn Lane, Henri Ménager, Aaron Gettel, Carol R Braun
OBJECTIVES: We evaluated a novel syndromic surveillance query, developed by the Council of State and Territorial Epidemiologists (CSTE) Heat Syndrome Workgroup, for identifying heat-related illness cases in near real time, using emergency department and inpatient hospital data from Maricopa County, Arizona, in 2015. METHODS: The Maricopa County Department of Public Health applied 2 queries for heat-related illness to area hospital data transmitted to the National Syndromic Surveillance Program BioSense Platform: the BioSense "heat, excessive" query and the novel CSTE query...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28692389/evaluation-of-the-components-of-the-north-carolina-syndromic-surveillance-system-heat-syndrome-case-definition
#7
Laurel Harduar Morano, Anna E Waller
OBJECTIVES: To improve heat-related illness surveillance, we evaluated and refined North Carolina's heat syndrome case definition. METHODS: We analyzed North Carolina emergency department (ED) visits during 2012-2014. We evaluated the current heat syndrome case definition (ie, keywords in chief complaint/triage notes or International Classification of Diseases, Ninth Revision, Clinical Modification [ ICD-9-CM] codes) and additional heat-related inclusion and exclusion keywords...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28692384/advancing-the-use-of-emergency-department-syndromic-surveillance-data-new-york-city-2012-2016
#8
Ramona Lall, Jasmine Abdelnabi, Stephanie Ngai, Hilary B Parton, Kelly Saunders, Jessica Sell, Amanda Wahnich, Don Weiss, Robert W Mathes
INTRODUCTION: The use of syndromic surveillance has expanded from its initial purpose of bioterrorism detection. We present 6 use cases from New York City that demonstrate the value of syndromic surveillance for public health response and decision making across a broad range of health outcomes: synthetic cannabinoid drug use, heat-related illness, suspected meningococcal disease, medical needs after severe weather, asthma exacerbation after a building collapse, and Ebola-like illness in travelers returning from West Africa...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28662696/contribution-of-trans-regulatory-eqtl-to-cryptic-genetic-variation-in-c-elegans
#9
Basten L Snoek, Mark G Sterken, Roel P J Bevers, Rita J M Volkers, Arjen Van't Hof, Rachel Brenchley, Joost A G Riksen, Andrew Cossins, Jan E Kammenga
BACKGROUND: Cryptic genetic variation (CGV) is the hidden genetic variation that can be unlocked by perturbing normal conditions. CGV can drive the emergence of novel complex phenotypes through changes in gene expression. Although our theoretical understanding of CGV has thoroughly increased over the past decade, insight into polymorphic gene expression regulation underlying CGV is scarce. Here we investigated the transcriptional architecture of CGV in response to rapid temperature changes in the nematode Caenorhabditis elegans...
June 29, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28628050/arizona-hospital-discharge-and-emergency-department-database-implications-for-occupational-health-surveillance
#10
Philip Harber, Jennifer Ha, Matthew Roach
OBJECTIVES: The objective of the project was to identify trends in emergency department visits and inpatient admissions for occupational injury and disease frequency and describe the financial impact from specific clinical groups known to have occupational risk factors. METHODS: Workers compensation cases among 19 million records in the Arizona statewide hospital discharge database (HDD) were assessed for seven clinical groups from 2008 to 2014, including back, cardiac, carpal tunnel syndrome, heat-related, psychiatric, pulmonary, and trauma...
April 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28616614/an-analysis-of-emergency-medical-services-demand-time-of-day-day-of-the-week-and-location-in-the-city
#11
Gorkem Sariyer, Mustafa Gokalp Ataman, Serhat Akay, Turhan Sofuoglu, Zeynep Sofuoglu
OBJECTIVE: Effective planning of Emergency Medical Services (EMS), which is highly dependent on the analysis of past data trends, is important in reducing response time. Thus, we aimed to analyze demand for these services based on time and location trends to inform planning for an effective EMS. MATERIALS AND METHODS: Data for this retrospective study were obtained from the Izmir EMS 112 system. All calls reaching these services during first six months of 2013 were descriptively analyzed, based on time and location trends as a heat-map form...
June 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28606202/an-assessment-of-climate-change-impacts-on-los-angeles-california-usa-hospitals-wildfires-highest-priority
#12
Sabrina A Adelaine, Mizuki Sato, Yufang Jin, Hilary Godwin
Introduction Although many studies have delineated the variety and magnitude of impacts that climate change is likely to have on health, very little is known about how well hospitals are poised to respond to these impacts. Hypothesis/Problem The hypothesis is that most modern hospitals in urban areas in the United States need to augment their current disaster planning to include climate-related impacts. METHODS: Using Los Angeles County (California USA) as a case study, historical data for emergency department (ED) visits and projections for extreme-heat events were used to determine how much climate change is likely to increase ED visits by mid-century for each hospital...
June 13, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28599264/time-series-analysis-of-heat-waves-and-emergency-department-visits-in-atlanta-1993-to-2012
#13
(no author information available yet)
BACKGROUND: Heat waves are extreme weather events that have been associated with adverse health outcomes. However, there is limited knowledge of heat waves' impact on population morbidity, such as emergency department (ED) visits. OBJECTIVES: We investigated associations between heat waves and ED visits for 17 outcomes in Atlanta over a 20-year period, 1993-2012. METHODS: Associations were estimated using Poisson log-linear models controlling for continuous air temperature, dew-point temperature, day of week, holidays, and time trends...
May 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28525284/intrinsically-disordered-proteins-as-important-players-during-desiccation-stress-of-soybean-radicles
#14
Yun Liu, Jiahui Wu, Nan Sun, Chengjian Tu, Xiaoying Shi, Hua Cheng, Simu Liu, Shuiming Li, Yong Wang, Yizhi Zheng, Vladimir N Uversky
Intrinsically disordered proteins (IDPs) play a variety of important physiological roles in all living organisms. However, there is no comprehensive analysis of the abundance of IDPs associated with environmental stress in plants. Here, we show that a set of heat-stable proteins (i.e., proteins that do not denature after boiling at 100 °C for 10 min) was present in R0mm and R15mm radicles (i.e., before radicle emergence and 15 mm long radicles) of soybean (Glycine max) seeds. This set of 795 iTRAQ-quantified heat-stable proteins contained a high proportion of wholly or highly disordered proteins (15%), which was significantly higher than that estimated for the whole soybean proteome containing 55,787 proteins (9%)...
May 30, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28520817/heat-in-the-southeastern-united-states-characteristics-trends-and-potential-health-impact
#15
Jeremy E Diem, Christine E Stauber, Richard Rothenberg
High summer temperatures in extratropical areas have an impact on the public's health, mainly through heat stress, high air pollution concentrations, and the transmission of tropical diseases. The purpose of this study is to examine the current characteristics of heat events and future projections of summer apparent temperature (AT)-and associated health concerns-throughout the southeastern United States. Synoptic climatology was used to assess the atmospheric characteristics of extreme heat days (EHDs) from 1979-2015...
2017: PloS One
https://www.readbyqxmd.com/read/28505754/generalized-balance-equations-for-charged-particle-transport-via-localized-and-delocalized-states-mobility-generalized-einstein-relations-and-fractional-transport
#16
Peter W Stokes, Bronson Philippa, Daniel Cocks, Ronald D White
A generalized phase-space kinetic Boltzmann equation for highly nonequilibrium charged particle transport via localized and delocalized states is used to develop continuity, momentum, and energy balance equations, accounting explicitly for scattering, trapping and detrapping, and recombination loss processes. Analytic expressions detail the effect of these microscopic processes on mobility and diffusivity. Generalized Einstein relations (GER) are developed that enable the anisotropic nature of diffusion to be determined in terms of the measured field dependence of the mobility...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28503805/development-of-a-siyalon-glaze-for-improved-osteoconductivity-of-implantable-medical-devices
#17
Ryan M Bock, Elia Marin, Alfredo Rondinella, Francesco Boschetto, Tetsuya Adachi, Bryan J McEntire, B Sonny Bal, Giuseppe Pezzotti
The application of bioactive coatings onto orthopaedic appliances is commonly performed to compensate for the otherwise bioinert nature of medical devices and to improve their osseointegration. Calcium phosphates, hydroxyapatite (HAp), and bioglasses are commercially available for this purpose. Until recently, few other inorganic compounds have been identified with similar biofunctionality. However, silicon nitride (Si3 N4 ) has emerged as a new orthopaedic material whose unique surface chemistry also enhances osteoconductivity...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28499499/heat-related-morbidity-and-mortality-in-new-england-evidence-for-local-policy
#18
Gregory A Wellenius, Melissa N Eliot, Kathleen F Bush, Dennis Holt, Rebecca A Lincoln, Andy E Smith, Julia Gold
BACKGROUND: Heat-related morbidity and mortality is a recognized public health concern. However, public health officials need to base policy decisions on local evidence, which is often lacking for smaller communities. OBJECTIVES: To evaluate the association between maximum daily heat index (HI) and morbidity and mortality in 15 New England communities (combined population: 2.7 million) in order to provide actionable evidence for local officials. METHODS: We applied overdispersed Poisson nonlinear distributed lag models to evaluate the association between HI and daily (May-September) emergency department (ED) admissions and deaths in each of 15 study sites in New Hampshire, Maine, and Rhode Island, controlling for time trends, day of week, and federal holidays...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28447447/nuclear-targeting-gold-nanorods-for-extremely-low-nir-activated-photothermal-therapy
#19
Limin Pan, Jianan Liu, Jianlin Shi
Photorelated nanomedicine is of particular interest as an emerging paradigm toward precise cancer therapy, as demonstrated by recent developments of photothermal therapy (PTT), an emerging technique employing light-converting agents to burn cancerous cells by overdosed optical energy-converted heat. However, most of the laser irradiations needed for effective PTT significantly exceed the maximal permissible power density in human skin, which is likely to damage surrounding normal tissues. Herein, we report a strategy of intranuclear PTT of cancer enabled by nuclear-targeted delivery of gold nanorods of ∼10...
May 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28437773/are-hospital-emergency-department-visits-due-to-dog-bites-associated-with-ambient-temperature-a-time-series-study-in-beijing-china
#20
Yongming Zhang, Qi Zhao, Wenyi Zhang, Shanshan Li, Gongbo Chen, Zhihai Han, Yuming Guo
BACKGROUND: It is well documented that suboptimal ambient temperature is associated with cardiovascular and respiratory diseases. However, no study has examined the relation between temperature and dog bites. OBJECTIVES: To study the association between ambient temperature and daily hospital emergency department visits due to dog bites (EDVDBs) in Beijing, China; and to explore whether the temperature-EDVDB association varies by sex and age. METHODS: Daily EDVDBs were collected from a hospital appointed for dog bites in Beijing during 2012-2014...
November 15, 2017: Science of the Total Environment
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