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https://www.readbyqxmd.com/read/29774376/roles-of-heat-shock-factor-1-beyond-the-heat-shock-response
#1
REVIEW
János Barna, Péter Csermely, Tibor Vellai
Various stress factors leading to protein damage induce the activation of an evolutionarily conserved cell protective mechanism, the heat shock response (HSR), to maintain protein homeostasis in virtually all eukaryotic cells. Heat shock factor 1 (HSF1) plays a central role in the HSR. HSF1 was initially known as a transcription factor that upregulates genes encoding heat shock proteins (HSPs), also called molecular chaperones, which assist in refolding or degrading injured intracellular proteins. However, recent accumulating evidence indicates multiple additional functions for HSF1 beyond the activation of HSPs...
May 17, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29770536/combination-of-ifitm1-knockdown-and-radiotherapy-inhibits-the-growth-of-oral-cancer
#2
Jie Yang, Lei Li, Yan Xi, Ruimei Sun, Hu Wang, Yanxin Ren, Liufang Zhao, Xiaoli Wang, Xiaojiang Li
This research aimed to analyze the effect of IFITM1 on the radioresistance of oral neoplasm. IFITM1 emerged using multi-group heat map from GSE9716 analysis of GEO database as the relevant radioresistance gene. IFITM1 was screened by TCGA database before its expression was analyzed. IFITM1 expression was quantified by qRT-PCR and immunohistochemistry in 19 paired oral neoplasm cases. The effects of time and dose of radiation on IFITM1 expression level in CAL27 and TSCC1 cell lines was tested via qRT-PCR. Oral neoplasm cells were transfected with siRNA after radiotherapy to disturb IFITM1 expression...
May 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29755958/gut-microbiota-contributes-to-resistance-against-pneumococcal-pneumonia-in-immunodeficient-rag-mice
#3
Krysta M Felix, Ivan A Jaimez, Thuy-Vi V Nguyen, Heqing Ma, Walid A Raslan, Christina N Klinger, Kristian P Doyle, Hsin-Jung J Wu
Streptococcus pneumoniae causes infection-related mortality worldwide. Immunocompromised individuals, including young children, the elderly, and those with immunodeficiency, are especially vulnerable, yet little is known regarding S. pneumoniae- related pathogenesis and protection in immunocompromised hosts. Recently, strong interest has emerged in the gut microbiota's impact on lung diseases, or the "gut-lung axis." However, the mechanisms of gut microbiota protection against gut-distal lung diseases like pneumonia remain unclear...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29742138/a-novel-early-risk-assessment-tool-for-detecting-clinical-outcomes-in-patients-with-heat-related-illness-j-erato-score-development-and-validation-in-independent-cohorts-in-japan
#4
Kei Hayashida, Yutaka Kondo, Toru Hifumi, Junya Shimazaki, Yasutaka Oda, Shinichiro Shiraishi, Tatsuma Fukuda, Junichi Sasaki, Keiki Shimizu
BACKGROUND: We sought to develop a novel risk assessment tool to predict the clinical outcomes after heat-related illness. METHODS: Prospective, multicenter observational study. Patients who transferred to emergency hospitals in Japan with heat-related illness were registered. The sample was divided into two parts: 60% to construct the score and 40% to validate it. A binary logistic regression model was used to predict hospital admission as a primary outcome. The resulting model was transformed into a scoring system...
2018: PloS One
https://www.readbyqxmd.com/read/29725631/kidney-diseases-in-agricultural-communities-a-case-against-heat-stress-nephropathy
#5
REVIEW
Chula Herath, Channa Jayasumana, P Mangala C S De Silva, P H Chaminda De Silva, Sisira Siribaddana, Marc E De Broe
The beginning of the 21st century has seen the emergence of a new chronic tubulo-interstitial kidney disease of uncertain cause among agricultural communities in Central America and Sri Lanka. Despite many similarities in demography, presentation, clinical features, and renal histopathology in affected individuals in these regions, a toxic etiology has been considered mainly in Sri Lanka, whereas the predominant hypothesis in Central America has been that recurrent acute kidney injury (AKI) caused by heat stress leads to chronic kidney disease (CKD)...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29723551/evaluation-of-airborne-asbestos-exposure-from-routine-handling-of-asbestos-containing-wire-gauze-pads-in-the-research-laboratory
#6
Ediberto Garcia, Daniel Newfang, Jayme P Coyle, Charles L Blake, John W Spencer, Leonard G Burrelli, Giffe T Johnson, Raymond D Harbison
Three independently conducted asbestos exposure evaluations were conducted using wire gauze pads similar to standard practice in the laboratory setting. All testing occurred in a controlled atmosphere inside an enclosed chamber simulating a laboratory setting. Separate teams consisting of a laboratory technician, or technician and assistant simulated common tasks involving wire gauze pads, including heating and direct wire gauze manipulation. Area and personal air samples were collected and evaluated for asbestos consistent with the National Institute of Occupational Safety Health method 7400 and 7402, and the Asbestos Hazard Emergency Response Act (AHERA) method...
April 30, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29702234/immuno-protective-role-of-biologically-synthesized-dietary-selenium-nanoparticles-against-multiple-stressors-in-pangasinodon-hypophthalmus
#7
Neeraj Kumar, K K Krishnani, Sanjay Kumar Gupta, Rupam Sharma, Raju Baitha, Dilip Kumar Singh, Narendra Pratap Singh
An environment friendly and sustainable approach is being emerged in the area of nanotechnology for accelerated growth and development of culturable aquatic animals hence green chemistry is gaining momentum in recent years. The present study has been carried out to delineate the effects of selenium nanoparticles (Se-NPs) on growth performance, antioxidative status and immunity of fish reared under lead (Pb) and high temperature (34 °C). Three hundred and sixty five fish were equally distributed in seven treatments in triplicates...
April 24, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29701411/true-brachial-artery-aneurysm-after-arteriovenous-fistula-for-hemodialysis-case-report
#8
Tiago Soares, Ricardo Castro-Ferreira, João Rocha Neves, Marina Neto, Joel Sousa, José Pedro Pinto, Luis Gamas, Alfredo Cerqueira, Sérgio Sampaio, José Fernando Teixeira
INTRODUCTION: Brachial artery aneurysms are relatively uncommon and generally due to infectious, post-traumatic or iatrogenic etiology. They seem to affect 4.5% of arteriovenous fistula. The usual manifestation is an accidental finding of a pulsatile, painless, and asymptomatic mass. Complications include sac thrombosis, thromboembolic ischaemic events, and disruption with profuse bleeding. METHODS: The aim of this study is to present a case of true brachial artery aneurysm in end-stage renal disease patient after arteriovenous fistula creation...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29688539/detection-of-dna-of-leishmania-siamensis-in-sergentomyia-neophlebotomus-iyengari-diptera-psychodidae-and-molecular-identification-of-blood-meals-of-sand-flies-in-an-affected-area-southern-thailand
#9
Suradej Siripattanapipong, Saovanee Leelayoova, Ubolrat Ninsaeng, Mathirut Mungthin
In Thailand, leishmaniasis is an emerging vector-borne disease that has become a public health concern. In related epidemiological surveys to identify potential Leishmania vectors in the affected areas, DNA of Leishmania martiniquensis (Kinetoplastida: Trypanosomatidae) was detected in Sergentomyia (Neophebotomus) gemmea (Diptera: Psychodidae) and Sergentomyia (Parrotomyia) barraudi (Diptera: Psychodidae). Recently, a more elaborate study was conducted in the same areas that included sand fly species identification, screening sand flies for the presence of Leishmania DNA and blood meal analysis to identify potential reservoir hosts directed toward assessing the risk of human infection...
April 24, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29681184/tam-infiltration-differences-in-tumor-first-and-zheng-first-models-and-the-underlying-inflammatory-molecular-mechanism-in-pancreatic-cancer
#10
Feng-Jiao Wang, Peng Wang, Lian-Yu Chen, Ya-Wen Geng, Hao Chen, Zhi-Qiang Meng, Lu-Ming Liu, Zhen Chen
BACKGROUND: Syndrome ( ZHENG in Chinese) in traditional Chinese medicine (TCM) refers to the intrinsic characteristics of a pathological process at a certain stage; these characteristics are influenced by internal and external environments and reveal the nature of a disease. Proper syndrome differentiation is the basic principle that guides clinical treatment. OBJECTIVE: To have a good understanding of tumor progression and the different mechanisms related to ZHENG that have occurred before and after tumor development and to explore the valid evaluation criteria of different pancreatic cancer syndromes to improve the guiding role of TCM syndrome differentiation in pancreatic cancer treatment...
April 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29676648/global-tobacco-use-old-and-new-products
#11
Ana Navas-Acien
Tobacco use and exposure to tobacco smoke remain major but avoidable causes of premature mortality and disease worldwide. Although the age-standardized prevalence of daily smoking has declined for both men and women in many countries, the number of smokers continues to increase because of global population growth. Although cigarettes are the most commonly used tobacco product, the tobacco epidemic has become tremendously complex with the emergence and popularity of alternative products such as waterpipes and electronic cigarettes (also known as e-cigarettes)...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29651510/-vomiting-and-collapse-of-a-28-year-old-male-long-distance-runner-in-middle-european-summer
#12
J Herold, A Mitrasch, E Lorenz, U Lodes, I Tanev, R Braun-Dullaeus, F Meyer
BACKGROUND: Hyperthermia often ends fatally and must therefore be promptly recognized and adequately treated. CASE: A 28-year-old man participated in a long-distance race (3 km) on a hot summer day (28 °C). The runner collapsed, had to vomit but continued the run and reached the finish. Neurologically, the patient presented with intermittent cerebral seizures. External cooling batteries were immediately applied and cold infusions were started. The patient was admitted to the intensive care unit of the university hospital (body temperature 40...
April 12, 2018: Der Internist
https://www.readbyqxmd.com/read/29650755/thermosensory-perception-regulates-speed-of-movement-in-response-to-temperature-changes-in-drosophila-melanogaster
#13
Andrea Soto-Padilla, Rick Ruijsink, Ody C M Sibon, Hedderik van Rijn, Jean-Christophe Billeter
Temperature influences physiology and behavior of all organisms. For ectotherms, which lack central temperature regulation, temperature adaptation requires sheltering from or moving to a heat source. As temperature constrains the rate of metabolic reactions, it can directly affect ectotherm physiology and thus behavioral performance. This direct effect is particularly relevant for insects whose small body readily equilibrates with ambient temperature. In fact, models of enzyme kinetics applied to insect behavior predict performance at different temperatures, suggesting that thermal physiology governs behavior...
April 12, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29643111/cardiovascular-and-cerebrovascular-emergency-department-visits-associated-with-wildfire-smoke-exposure-in-california-in-2015
#14
Zachary S Wettstein, Sumi Hoshiko, Jahan Fahimi, Robert J Harrison, Wayne E Cascio, Ana G Rappold
BACKGROUND: Wildfire smoke is known to exacerbate respiratory conditions; however, evidence for cardiovascular and cerebrovascular events has been inconsistent, despite biological plausibility. METHODS AND RESULTS: A population-based epidemiologic analysis was conducted for daily cardiovascular and cerebrovascular emergency department (ED) visits and wildfire smoke exposure in 2015 among adults in 8 California air basins. A quasi-Poisson regression model was used for zip code-level counts of ED visits, adjusting for heat index, day of week, seasonality, and population...
April 11, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29607045/effect-of-maternal-foraging-habitat-on-offspring-quality-in-the-loggerhead-sea-turtle-caretta-caretta
#15
Hideo Hatase, Kazuyoshi Omuta, Koutarou Itou, Teruhisa Komatsu
Exploring a trade-off between quantity and quality of offspring allows differences in the fitness between alternative life histories to be accurately evaluated. We addressed the mechanism that maintains alternative life histories (small oceanic planktivores vs. large neritic benthivores) observed in a loggerhead sea turtle ( Caretta caretta ) population, which has been suggested to be environmental, based on the lack of genetic structure and a large difference in reproductive output. We examined whether maternal foraging habitat affects offspring quality, by measuring the morphology, emergence success, and righting response of hatchlings following incubation in a common open sand area over the whole nesting season at Yakushima Island, Japan, and by recording early growth and survival of offspring that were reared in a common environment at a Japanese aquarium...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29601546/assessing-vulnerability-to-urban-heat-a-study-of-disproportionate-heat-exposure-and-access-to-refuge-by-socio-demographic-status-in-portland-oregon
#16
Jackson Voelkel, Dana Hellman, Ryu Sakuma, Vivek Shandas
Extreme urban heat is a powerful environmental stressor which poses a significant threat to human health and well-being. Exacerbated by the urban heat island phenomenon, heat events are expected to become more intense and frequent as climate change progresses, though we have limited understanding of the impact of such events on vulnerable populations at a neighborhood or census block group level. Focusing on the City of Portland, Oregon, this study aimed to determine which socio-demographic populations experience disproportionate exposure to extreme heat, as well as the level of access to refuge in the form of public cooling centers or residential central air conditioning...
March 30, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29601479/burden-and-risk-factors-for-cold-related-illness-and-death-in-new-york-city
#17
Kathryn Lane, Kazuhiko Ito, Sarah Johnson, Elizabeth A Gibson, Andrew Tang, Thomas Matte
Exposure to cold weather can cause cold-related illness and death, which are preventable. To understand the current burden, risk factors, and circumstances of exposure for illness and death directly attributed to cold, we examined hospital discharge, death certificate, and medical examiner data during the cold season from 2005 to 2014 in New York City (NYC), the largest city in the United States. On average each year, there were 180 treat-and-release emergency department visits (average annual rate of 21.6 per million) and 240 hospital admissions (29...
March 30, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29599023/comparative-environmental-and-human-health-evaluations-of-thermolysis-and-solvolysis-recycling-technologies-of-carbon-fiber-reinforced-polymer-waste
#18
Y F Khalil
This quantitative research aims to compare environmental and human health impacts associated with two recycling technologies of CFRP waste. The 'baseline' recycling technology is the conventional thermolysis process via pyrolysis and the 'alternative' recycling technology is an emerging chemical treatment via solvolysis using supercritical water (SCW) to digest the thermoset matrix. Two Gate-to-Gate recycling models are developed using GaBi LCA platform. The selected functional unit (FU) is 1 kg CFRP waste and the geographical boundary of this comparative LCIA is defined to be within the U...
March 26, 2018: Waste Management
https://www.readbyqxmd.com/read/29588164/nitrated-fatty-acids-in-cardiovascular-diseases
#19
REVIEW
Martin Mollenhauer, Dennis Mehrkens, Volker Rudolph
Cardiovascular disease (CVD) is the leading cause of death and accounts for one third of disease-related mortality worldwide. Dysregulated redox mechanisms, in particular the formation of reactive oxygen species (ROS) play a pivotal pathogenetic role in CVD. Nitro-fatty acids (NO2 -FAs) are electrophilic molecules which have a NO2 -group bound to one of their olefinic carbons. They are endogenously formed by the reaction of reactive nitrogen species with unsaturated fatty acids. Basal levels of NO2 -FAs are in the low nanomolar range and higher concentrations can be encountered under acidic (stomach) and inflammatory (e...
March 24, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29578086/batio-3-core-au-shell-nanoparticles-for-photothermal-therapy-and-bimodal-imaging
#20
Yanfei Wang, Aoune Barhoumi, Rong Tong, Weiping Wang, Tianjiao Ji, Xiaoran Deng, Lele Li, Sophie A Lyon, Gally Reznor, David Zurakowski, Daniel S Kohane
We report sub-100 nm metal-shell (Au) dielectric-core (BaTiO3 ) nanoparticles with bimodal imaging abilities and enhanced photothermal effects. The nanoparticles efficiently absorb light in the near infrared range of the spectrum and convert it to heat to ablate tumors. Their BaTiO3 core, a highly ordered non-centrosymmetric material, can be imaged by second harmonic generation, and their Au shell generates two-photon luminescence. The intrinsic dual imaging capability allows investigating the distribution of the nanoparticles in relation to the tumor vasculature morphology during photothermal ablation...
March 22, 2018: Acta Biomaterialia
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