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https://www.readbyqxmd.com/read/28315949/-89-zr-onartuzumab-pet-imaging-of-c-met-receptor-dynamics
#1
Martin Pool, Anton G T Terwisscha van Scheltinga, Arjan Kol, Danique Giesen, Elisabeth G E de Vries, Marjolijn N Lub-de Hooge
PURPOSE: c-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug efficacy or emergence of resistance. Noninvasive visualization of c-MET dynamics could therefore potentially guide c-MET-directed therapies. We investigated the feasibility of (89)Zr-labelled one-armed c-MET antibody onartuzumab PET for detecting relevant changes in c-MET levels induced by c-MET-mediated epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib resistance or heat shock protein-90 (HSP90) inhibitor NVP-AUY-922 treatment in human non-small-cell lung cancer (NSCLC) xenografts...
March 19, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28314926/american-football-and-fatal-exertional-heat-stroke-a-case-study-of-korey-stringer
#2
Andrew Grundstein, John A Knox, Jennifer Vanos, Earl R Cooper, Douglas J Casa
On August 1, 2001, Korey Stringer, a Pro Bowl offensive tackle for the Minnesota Vikings, became the first and to date the only professional American football player to die from exertional heat stroke (EHS). The death helped raise awareness of the dangers of exertional heat illnesses in athletes and prompted the development of heat safety policies at the professional, collegiate, and interscholastic levels. Despite the public awareness of this death, no published study has examined in detail the circumstances surrounding Stringer's fatal EHS...
March 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28301350/a-phase-ii-study-of-ganetespib-as-second-line-or-third-line-therapy-for-metastatic-pancreatic-cancer
#3
Dana B Cardin, Ramya Thota, Laura W Goff, Jordan D Berlin, Clyde M Jones, Gregory D Ayers, Jennifer G Whisenant, Emily Chan
OBJECTIVES: Heat shock protein 90 regulates multiple signaling proteins involved in key pathways of pancreatic cancer pathogenesis. Ganetespib binds to heat shock protein 90 and interferes with its binding to client proteins thus leading to inactivation and degradation of the signaling proteins that promote cancer progression. This phase II study was designed to evaluate the efficacy of ganetespib in patients with refractory metastatic pancreatic cancer (rMPC). METHODS: Patients with rMPC received 175 mg/m ganetespib intravenously once weekly for 3 weeks in 4-week cycles...
March 15, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28300610/changes-in-microrna-abundance-may-regulate-diapause-in-the-flesh-fly-sarcophaga-bullata
#4
Julie A Reynolds, Justin T Peyton, David L Denlinger
Diapause, an alternative developmental pathway characterized by changes in developmental timing and metabolism, is coordinated by molecular mechanisms that are not completely understood. MicroRNA (miRNA) mediated gene silencing is emerging as a key component of animal development and may have a significant role in initiating, maintaining, and terminating insect diapause. In the present study, we test this possibility by using high-throughput sequencing and qRT-PCR to discover diapause-related shifts in miRNA abundance in the flesh fly, Sarcophaga bullata...
March 11, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28282618/integrating-multiple-stressors-across-life-stages-and-latitudes-combined-and-delayed-effects-of-an-egg-heat-wave-and-larval-pesticide-exposure-in-a-damselfly
#5
Szymon Sniegula, Lizanne Janssens, Robby Stoks
To understand the effects of pollutants in a changing world we need multistressor studies that combine pollutants with other stressors associated with global change such as heat waves. We tested for the delayed and combined impact of a heat wave during the egg stage and subsequent sublethal exposure to the pesticide esfenvalerate during the larval stage on life history and physiology in the larval and adult stage of the damselfly Lestes sponsa. We studied this in a common garden experiment with replicated central- and high latitude populations to explore potential effects of local thermal adaptation and differences in life history shaping the multistressor responses...
March 1, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28268879/optimal-control-of-inspired-perfluorocarbon-temperature-for-induction-of-hypothermia-by-total-liquid-ventilation-in-juvenile-lamb-model
#6
Mathieu Nadeau, Michael Sage, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau
Mild hypothermia is well known for its therapeutic value in cardio- and neuroprotection. Many recent experimental studies have shown that the swiftness of the cooling offered by total liquid ventilation (TLV) holds great promise in achieving maximal therapeutic effect. TLV is an emerging ventilation technique in which the lungs are filled with breathable liquids, namely perfluorocarbons (PFCs). A liquid ventilator ensures subject ventilation by periodically renewing a volume of oxygenated, CO2-free and temperature-controlled breathable PFC...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28240166/synthesis-of-medicinally-privileged-heterocycles-through-dielectric-heating
#7
Debasish Bandyopadhyay, Bimal K Banik
This review summarizes the potential application of microwave irradiation (dielectric heating) to synthesize biologically important heterocyclic small molecules in the recent past. A huge number of heterocyclic compounds are present in various natural sources like plant, marine microbe or other organisms and many of them possess unique biological activity. In addition to nature-derived heterocyclic compounds, a large number of synthetic heterocycles are being used as medicines. This review describes the relevant recent examples of microwave irradiation to accomplish various chemical transformations accelerated by a variety of catalysts which include, but not limited to, Lewis acids, other metal containing catalysts, organocatalysts, heterogeneous catalysts, phase-transfer catalysts, solid-supported catalysts, inorganic catalysts (bases, acids and salts) and so on...
February 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28238050/wing-shape-mediated-carry-over-effects-of-a-heat-wave-during-the-larval-stage-on-post-metamorphic-locomotor-ability
#8
Hélène Arambourou, Iago Sanmartín-Villar, Robby Stoks
Two key insights to better assess the ecological impact of global warming have been poorly investigated to date: global warming effects on the integrated life cycle and effects of heat waves. We tested the effect of a simulated mild (25 °C) and severe (30 °C) heat wave experienced during the larval stage on the flight ability of the damselfly Ischnura elegans. To get a mechanistic understanding of how heat stress may translate into reduced post-metamorphic flight ability, we evaluated the hypothesized mediatory role of adult size-related traits, and also tested alternative pathways operating through changes in wing shape and two flight-related traits (both relative fat and flight muscle contents)...
February 25, 2017: Oecologia
https://www.readbyqxmd.com/read/28237841/relationship-between-serum-anti-heat-shock-protein-27-antibody-levels-and-obesity
#9
Mehrdad Kargari, Samira Tavassoli, Amir Avan, Mahmoud Ebrahimi, Mahmoud Reza Azarpazhooh, Rasool Asoodeh, Mohsen Nematy, Seyed Mahdi Hassanian, Farzad Rahmani, Elham Mohammadzade, Habibollah Esmaeili, Mohsen Moohebati, Gordon A Ferns, Majid Ghayour-Mobarhan, Seyed Mohammad Reza Parizadeh
BACKGROUND: Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is expressed at high levels following the exposure of cells to environmental stressors such as heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been reported in several conditions including cardiovascular disease and cancers. We measured serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between serum anti-HSP27 antibody levels and demographic characteristics including coronary risk factors...
February 22, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28235600/descending-facilitatory-pain-pathways-mediate-ongoing-pain-and-tactile-hypersensitivity-in-a-rat-model-of-trigeminal-neuropathic-pain
#10
C F M Nones, R F Claudino, L E N Ferreira, R C Dos Reis, T King, J G Chichorro
The Chronic Constriction Injury of the Infraorbital Nerve (CCI-ION) is a well-established model to study facial sensory changes related to trigeminal neuropathic pain. CCI-ION induces heat hypersensitivity that resolves within 2-3 weeks and a delayed mechanical hypersensitivity that emerges during the second week post-injury. The role of descending facilitatory pain pathways from the rostro ventromedial medulla (RVM) in mediating the heat and tactile hypersensitivity was examined. CCI-ION induced heat hypersensitivity observed 5days post-surgery was reversed by systemic, but not RVM lidocaine...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28229462/harmonization-of-nucleic-acid-testing-for-zika-virus-development-of-the-1-st-world-health-organization-international-standard
#11
Sally A Baylis, Kay-Martin O Hanschmann, Barbara S Schnierle, Jan-Hendrik Trösemeier, Johannes Blümel
BACKGROUND: With the ongoing public health emergency due to Zika virus (ZIKV), nucleic acid testing (NAT) is essential for clinical diagnosis and screening of blood donors. However, NAT for ZIKV has not been standardized, and this study was performed to establish a World Health Organization (WHO) International Standard (IS) for ZIKV RNA; WHO ISs have been used to improve detection and quantification of blood-borne viruses. STUDY DESIGN AND METHODS: The candidate IS (cIS), code number 11468/16, was prepared by heat inactivation and lyophilization of a ZIKV strain isolated from a patient in French Polynesia in 2013...
February 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28227077/optimal-control-of-inspired-perfluorocarbon-temperature-for-induction-of-hypothermia-by-total-liquid-ventilation-in-juvenile-lamb-model
#12
Mathieu Nadeau, Michael Sage, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau, Mathieu Nadeau, Michael Sage, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau, Michael Sage, Philippe Micheau, Jean-Paul Praud, Mathieu Nadeau, Herve Walti, Renaud Tissier
Mild hypothermia is well known for its therapeutic value in cardio- and neuroprotection. Many recent experimental studies have shown that the swiftness of the cooling offered by total liquid ventilation (TLV) holds great promise in achieving maximal therapeutic effect. TLV is an emerging ventilation technique in which the lungs are filled with breathable liquids, namely perfluorocarbons (PFCs). A liquid ventilator ensures subject ventilation by periodically renewing a volume of oxygenated, CO2-free and temperature-controlled breathable PFC...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28210860/a-heat-vulnerability-index-to-improve-urban-public-health-management-in-san-juan-puerto-rico
#13
Pablo Méndez-Lázaro, Frank E Muller-Karger, Daniel Otis, Matthew J McCarthy, Ernesto Rodríguez
Increased frequency and length of high heat episodes are leading to more cardiovascular issues and asthmatic responses among the population of San Juan, the capital of the island of Puerto Rico, USA. An urban heat island effect, which leads to foci of higher temperatures in some urban areas, can raise heat-related mortality. The objective of this research is to map the risk of high temperature in particular locations by creating heat maps of the city of San Juan. The heat vulnerability index (HVI) maps were developed using images collected by satellite-based remote sensing combined with census data...
February 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28176835/microscopic-description-for-the-emergence-of-collective-dissipation-in-extended-quantum-systems
#14
Fernando Galve, Antonio Mandarino, Matteo G A Paris, Claudia Benedetti, Roberta Zambrini
Practical implementations of quantum technology are limited by unavoidable effects of decoherence and dissipation. With achieved experimental control for individual atoms and photons, more complex platforms composed by several units can be assembled enabling distinctive forms of dissipation and decoherence, in independent heat baths or collectively into a common bath, with dramatic consequences for the preservation of quantum coherence. The cross-over between these two regimes has been widely attributed in the literature to the system units being farther apart than the bath's correlation length...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28141809/self-organised-criticality-in-the-evolution-of-a-thermodynamic-model-of-rodent-thermoregulatory-huddling
#15
Stuart P Wilson
A thermodynamic model of thermoregulatory huddling interactions between endotherms is developed. The model is presented as a Monte Carlo algorithm in which animals are iteratively exchanged between groups, with a probability of exchanging groups defined in terms of the temperature of the environment and the body temperatures of the animals. The temperature-dependent exchange of animals between groups is shown to reproduce a second-order critical phase transition, i.e., a smooth switch to huddling when the environment gets colder, as measured in recent experiments...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28133853/molecular-response-of-sargassum-vulgare-to-acidification-at-volcanic-co2-vents-insights-from-de-novo-transcriptomic-analysis
#16
Amit Kumar, Immacolata Castellano, Francesco Paolo Patti, Massimo Delledonne, Hamada Abdelgawad, Gerrit T S Beemster, Han Asard, Anna Palumbo, Maria Cristina Buia
Ocean acidification is an emerging problem that is expected to impact ocean species to varying degrees. Currently, little is known about its effect on molecular mechanisms induced in fleshy macroalgae. To elucidate genome wide responses to acidification, a comparative transcriptome analysis was carried out between Sargassum vulgare populations growing under acidified conditions at volcanic CO2 vents and a control site. Several transcripts involved in a wide range of cellular and metabolic processes were differentially expressed...
January 30, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28127181/non-surgical-ablative-therapy-for-management-of-small-renal-masses-current-status-and-future-trends
#17
REVIEW
K Farrag, S Sriprasad
A large number of small renal masses (SRMs) with size less than 4 cm are being identified due to advances in diagnostic imaging. As the natural history of these tumours remains unknown, there is no reliable way to predict their behaviour or future growth. Although, partial nephrectomy is the gold standard for treatment of these tumours, ablative non-surgical therapies such as cryoablation and radiofrequency ablation provide a less invasive option of treatment with comparable oncological outcomes. In this systematic review, the principle, indications, methods of treatment, oncological control, complication and renal function of ablative therapies are critically reviewed...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28123861/thermal-injury-patterns-associated-with-electronic-cigarettes
#18
Alisha Z Jiwani, James F Williams, Julie A Rizzo, Kevin K Chung, Booker T King, Leopoldo C Cancio
E-cigarettes are typically lithium-ion battery-operated devices that simulate smoking by heating a nicotine-solution into a vapor that the user inhales. E-cigarette use is becoming rapidly popular as an alternative to traditional cigarette smoking. This report describes an emerging problem associated with e-cigarettes, consisting of 10 thermally injured patients seen at a single burn center over a 2-year period from 2014 to 2016. Our cohort was comprised mainly of young adults who sustained mixed partial and full thickness burns as a result of e-cigarette-related explosions...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28119443/measuring-physical-stigmata-of-niacin-associated-skin-toxicity-by-colorimetry-white-light-spectroscopy-laser-doppler-flowmetry-and-thermometry-in-combination-with-symptom-perception-scoring-methods-to-aid-development-of-niacin-mimetics
#19
Richard L Dunbar, Harsh Goel, Sony Tuteja, Wen-Liang Song, Grace Nathanson, Zeeshan Babar, Dusanka Lalic, Joel M Gelfand, Daniel J Rader, Gary L Grove
Though cardioprotective, niacin monotherapy is limited by unpleasant cutaneous symptoms mimicking dermatitis: Niacin-Associated Skin Toxicity (NASTy). Niacin is prototypical of several emerging drugs suffering off-target rubefacient properties, whereby agonizing the GPR109A receptor on cutaneous immune cells provokes vasodilation, prompting skin plethora and rubor, as well as dolor, tumor, and calor, and systemically, heat loss, frigor, chills, and rigors. Typically, NASTy effects are described by subjective, patient-reported perception, at best semi-quantitative and bias-prone...
January 23, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28112940/adaptive-landscape-flattening-accelerates-sampling-of-alchemical-space-in-multisite-%C3%AE-dynamics
#20
Ryan L Hayes, Kira A Armacost, Jonah Z Vilseck, Charles L Brooks
Multisite λ dynamics (MSλD) is a powerful emerging method in free energy calculation that allows prediction of relative free energies for a large set of compounds from very few simulations. Calculating free energy differences between substituents that constitute large volume or flexibility jumps in chemical space is difficult for free energy methods in general, and for MSλD in particular, due to large free energy barriers in alchemical space. This study demonstrates that a simple biasing potential can flatten these barriers and introduces an algorithm that determines system specific biasing potential coefficients...
February 10, 2017: Journal of Physical Chemistry. B
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