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Heat related emergencies

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https://www.readbyqxmd.com/read/28938469/taming-the-flames-targeting-white-adipose-tissue-browning-in-hypermetabolic-conditions
#1
Abdikarim Abdullahi, Marc G Jeschke
In this era of increased obesity and diabetes prevalence, the browning of white adipose tissue (WAT) has emerged as a promising therapeutic target to induce weight loss and improve insulin sensitivity in this population. The browning process entails a shift in the WAT from primarily storing excess energy to the dissipation of energy as heat. However, this idealistic view of WAT browning being the saviour of the metabolic syndrome has been criticized by studies in burns and cancer patients that have shown browning to be detrimental rather than being beneficial...
August 30, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28934724/integrating-health-into-local-climate-response-lessons-from-the-u-s-cdc-climate-ready-states-and-cities-initiative
#2
Mary C Sheehan, Mary A Fox, Charlotte Kaye, Beth Resnick
Public health has potential to serve as a frame to convey the urgency of behavior change needed to adapt to a changing climate and reduce greenhouse gas emissions. Local governments form the backbone of climate-related public health preparedness. Yet local health agencies are often inadequately prepared and poorly integrated into climate change assessments and plans. We reviewed the climate health profiles of 16 states and two cities participating in the U.S. Centers for Disease Control and Prevention (CDC)'s Climate-Ready States and Cities Initiative (CRSCI) that aims to build local capacity to assess and respond to the health impacts of climate change...
September 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28923709/the-impact-of-heat-waves-and-cold-spells-on-respiratory-emergency-department-visits-in-beijing-china
#3
Xuping Song, Shigong Wang, Tanshi Li, Jinhui Tian, Guowu Ding, Jiaxin Wang, Jiexin Wang, Kezheng Shang
The objectives of this article were (i) to find the association between extreme temperatures and respiratory emergency department (ED) visits and (ii) to explore the added effects of heat waves and cold spells on respiratory ED visits in Beijing from 2009 to 2012. A quasi-Poisson generalised linear model combined with a distributed lag non-linear model was performed to quantify this association. The results indicated that (i) ambient temperature related to respiratory ED visits exhibited a U-shaped association...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28914306/enhanced-intermediate-temperature-co2-splitting-using-nonstoichiometric-ceria-and-ceria-zirconia
#4
Zhenlong Zhao, Mruthunjaya Uddi, Nikolai Tsvetkov, Bilge Yildiz, Ahmed F Ghoniem
CO2 splitting via thermo-chemical or reactive redox has emerged as a novel and promising carbon-neutral energy solution. Its performance depends critically on the properties of the oxygen carriers (OC). Ceria is recognized as one of the most promising OC candidates, because of its fast chemistry, high ionic diffusivity, and large oxygen storage capacity. The fundamental surface ion-incorporation pathways, along with the role of surface defects and the adsorbates remain largely unknown. This study presents a detailed kinetics study of CO2 splitting using CeO2 and Ce0...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28902917/hsp70-j-protein-machinery-from-glossina-morsitans-morsitans-vector-of-african-trypanosomiasis
#5
Stephen J Bentley, Aileen Boshoff
Tsetse flies (Glossina spp.) are the sole vectors of the protozoan parasites of the genus Trypanosoma, the causative agents of African Trypanosomiasis. Species of Glossina differ in vector competence and Glossina morsitans morsitans is associated with transmission of Trypanosoma brucei rhodesiense, which causes an acute and often fatal form of African Trypanosomiasis. Heat shock proteins are evolutionarily conserved proteins that play critical roles in proteostasis. The activity of heat shock protein 70 (Hsp70) is regulated by interactions with its J-protein (Hsp40) co-chaperones...
2017: PloS One
https://www.readbyqxmd.com/read/28888667/preimmunization-with-a-heat-killed-preparation-of-mycobacterium-vaccae-enhances-fear-extinction-in-the-fear-potentiated-startle-paradigm
#6
James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowry
The hygiene hypothesis or "Old Friends" hypothesis proposes that inflammatory diseases are increasing in modern urban societies, due in part to reduced exposure to microorganisms that drive immunoregulatory circuits, and a failure to terminate inappropriate inflammatory responses. Inappropriate inflammation is also emerging as a risk factor for trauma-related, anxiety, and affective disorders, including posttraumatic stress disorder (PTSD), which is characterized as persistent re-experiencing of the trauma after a traumatic experience...
September 6, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28877241/real-time-surveillance-of-heat-related-morbidity-relation-to-excess-mortality-associated-with-extreme-heat
#7
Robert W Mathes, Kazuhiko Ito, Kathryn Lane, Thomas D Matte
The impact of heat on mortality is well documented but deaths tend to occur after (or lag) extreme heat events, and mortality data is generally not available for timely surveillance during extreme heat events. Recently, systems for near-real time surveillance of heat illness have been reported but have not been validated as predictors of non-external cause of deaths associated with extreme heat events. We analyzed associations between daily weather conditions, emergency medical system (EMS) calls flagged as heat-related by EMS dispatchers, emergency department (ED) visits classified as heat-related based on chief complaint text, and excess non-external cause mortality in New York City...
2017: PloS One
https://www.readbyqxmd.com/read/28853883/characterization-of-the-degradation-profile-of-umbelliprenin-a-bioactive-prenylated-coumarin-of-a-ferulago-species
#8
Salvatore Genovese, Vito Alessandro Taddeo, Francesco Epifano, Serena Fiorito, Cécile Bize, Arnaud Rives, Philippe de Medina
Umbelliprenin is a secondary plant metabolite that displays promising chemopreventive, anti-inflammatory, and antigenotoxic properties. It possesses potential for applications to human welfare notably to prevent the emergence of cancer. For this purpose, stability studies are needed to define proper storage conditions and adapted formulations for this drug candidate. The identification of degradative products is a major concern for the preclinical development of umbelliprenin, providing also interesting information related to potential original phytochemicals formed in plants exposed to stressors...
August 30, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28829536/pediatric-heat-related-illness-recommendations-for-prevention-and-management-digest
#9
Roberta J Dunn, Tommy Y Kim, Pradip Chaudhari
Infants, children, and adolescents are at increased risk for heat-related illness due to their inability to remove themselves from dangerous environments. Evidence shows that morbidity and mortality from heat illness is related to the length of time core temperature is elevated, so rapid reduction and accurate serial measurements are crucial to prevention of organ system damage and death. The primary methods of patient cooling are conduction (ice-water immersion, cold packs) and convection (moisture and moving air)...
August 22, 2017: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/28825639/a-geographical-analysis-of-emergency-medical-service-calls-and-extreme-heat-in-king-county-wa-usa-2007-2012
#10
Aubrey C DeVine, Phuong T Vu, Michael G Yost, Edmund Y W Seto, Tania M Busch Isaksen
This research analyzed the relationship between extreme heat and Emergency Medical Service (EMS) calls in King County, WA, USA between 2007 and 2012, including the effect of community-level characteristics. Extreme heat thresholds for the Basic Life Support (BLS) data and the Advanced Life Support (ALS) data were found using a piecewise generalized linear model with Akaike Information Criterion (AIC). The association between heat exposure and EMS call rates was investigated using a generalized estimating equations with Poisson mean model, while adjusting for community-level indicators of poverty, impervious surface, and elderly population (65+)...
August 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28818509/the-use-of-high-flow-nasal-cannula-in-the-pediatric-emergency-department
#11
REVIEW
Katherine N Slain, Steven L Shein, Alexandre T Rotta
OBJECTIVES: To summarize the current literature describing high-flow nasal cannula use in children, the components and mechanisms of action of a high-flow nasal cannula system, the appropriate clinical applications, and its role in the pediatric emergency department. SOURCES: A computer-based search of PubMed/MEDLINE and Google Scholar for literature on high-flow nasal cannula use in children was performed. DATA SUMMARY: High-flow nasal cannula, a non-invasive respiratory support modality, provides heated and fully humidified gas mixtures to patients via a nasal cannula interface...
August 15, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28793217/mutation-in-the-core-structure-of-desmin-intermediate-filaments-affects-myoblast-elasticity
#12
Catherine Even, Gilles Abramovici, Florence Delort, Anna F Rigato, Virginie Bailleux, Abel de Sousa Moreira, Patrick Vicart, Felix Rico, Sabrina Batonnet-Pichon, Fatma Briki
Elastic properties of cells are mainly derived from the actin cytoskeleton. However, intermediate filaments are emerging as major contributors to the mechanical properties of cells. Using atomic force microscopy, we studied the elasticity of mouse myoblasts expressing a mutant form of the gene encoding for desmin intermediate filaments, p.D399Y. This variant produces desmin aggregates, the main pathological symptom of myofibrillar myopathies. Here we show that desmin-mutated cells display a 39% increased median elastic modulus compared to wild-type cells...
August 8, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28777512/carbon-monoxide-poisoning-in-utah-1996-2013
#13
Lindell K Weaver, Kayla Deru, Susan Churchill, Joshua Legler, Greg Snow, Todd Grey
INTRODUCTION: The true incidence of carbon monoxide (CO) poisoning is not clearly known, but a description of possible trends could aid in prevention. METHODS: Investigators searched Utah state databases for emergency department (ED) visits and admissions for CO poisoning and medical examiner records for CO-related fatalities. RESULTS: From 1996-2013, 7,590 individuals were diagnosed with CO poisoning: 6,469 were treated/ released from EDs; 596 were admitted; 525 died...
November 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28775351/setting-the-stage-for-debating-the-roles-of-risk-assessment-and-life-cycle-assessment-of-engineered-nanomaterials
#14
Jeroen B Guinée, Reinout Heijungs, Martina G Vijver, Willie J G M Peijnenburg
Although technological and environmental benefits are important stimuli for nanotechnology development, these technologies have been contested from an environmental point of view. The steady growth of applications of engineered nanomaterials has heated up the debate on quantifying the environmental repercussions. The two main scientific methods to address these environmental repercussions are risk assessment and life-cycle assessment. The strengths and weaknesses of each of these methods, and the relation between them, have been a topic of debate in the world of traditional chemistry for over two decades...
August 4, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28758577/translational-shift-of-hsp90-as-a-novel-therapeutic-target-from-cancer-to-neurodegenerative-disorders-an-emerging-trend-in-the-cure-of-alzheimer-s-and-parkinson-s-diseases
#15
Qamre Alam, Mohammad Zubair Alam, Khalid Hussain Wali Sait, Nisreen Anfinan, Abdul Wahab Noorwali, Mohd Sajjad Ahmad Khan, Mohammad A Kamal, Absarul Haque
Parkinson's disease (PD) is considered as the second most common neurodegenerative disorder after Alzheimer's disease (AD). Despite having extensive research, the apparent pathogenic mechanism of these neurodegenerative disorders has not yet been fully understood. Recently, a ubiquitous molecular chaperone known as Heat Shock Protein 90 (HSP90) has been shown to play a key role in averting protein mis-folding and involves in assisting immature protein aggregation through inhibition of apoptotic activity in neuro-inflammatory disease...
July 28, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28745084/patient-with-unresectable-cholangiocarcinoma-treated-with-radiofrequency-hyperthermia-in-combination-with-chemotherapy-a-case-report
#16
Juyoung Ryu, Kangwook Lee, Changmug Joe, JongCheon Joo, Namhun Lee, Hwa-Seung Yoo
Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy...
July 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28718257/risk-factors-for-heat-related-deaths-during-the-june-2015-heat-wave-in-karachi-pakistan
#17
Syed Ghazanfar Saleem, Tehreem Ansari, Ashraf Shamshad Ali, Sara Fatima, Mariam Hassan Rizvi, Muhammad Abdul Samad
BACKGROUND: Mortality as a consequence of heat related illness is a public health concern. Emergency department (ED) experiences increased patients' flow and decreased survival as a consequence of heat stroke during the episodes of heat wave. The present study was conducted to identify the risk factors for mortality among victims of heat wave (17th - 23rd June), 2015 evaluated in the Emergency Department of The Indus Hospital (TIH), Karachi. METHODS: In this cross-sectional study data was retrospectively collected...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28708081/modeling-the-effects-of-urban-design-on-emergency-medical-response-calls-during-extreme-heat-events-in-toronto-canada
#18
Drew A Graham, Jennifer K Vanos, Natasha A Kenny, Robert D Brown
Urban residents are at risk of health-related illness during extreme heat events but the dangers are not equal in all parts of a city. Previous studies have found a relationship between physical characteristics of neighborhoods and the number of emergency medical response (EMR) calls. We used a human energy budget model to test the effects of landscape modifications that are designed to cool the environment on the expected number of EMR calls in two neighborhoods in Toronto, Canada during extreme heat events...
July 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28700537/quantitative-sensory-testing-response-patterns-to-capsaicin-and-ultraviolet-b-induced-local-skin-hypersensitization-in-healthy-subjects-a-machine-learned-analysis
#19
Jörn Lötsch, Gerd Geisslinger, Sarah Heinemann, Florian Lerch, Bruno G Oertel, Alfred Ultsch
The comprehensive assessment of pain-related human phenotypes requires combinations of nociceptive measures that produce complex high-dimensional data, posing challenges to bioinformatic analysis. In this study, we assessed established experimental models of heat hyperalgesia of the skin, consisting of local ultraviolet-B (UV-B) irradiation or capsaicin application, in 82 healthy subjects using a variety of noxious stimuli. We extended the original heat stimulation by applying cold and mechanical stimuli and assessing the hypersensitization effects with a clinically established quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain)...
August 16, 2017: Pain
https://www.readbyqxmd.com/read/28696476/on-the-origin-of-the-driving-force-in-the-marangoni-propelled-gas-bubble-trapping-mechanism
#20
A Miniewicz, C Quintard, H Orlikowska, S Bartkiewicz
Gas bubbles can be trapped and then manipulated with laser light. In this report, we propose the detailed optical trapping mechanism of gas bubbles confined inside a thin light-absorbing liquid layer between two glass plates. The necessary condition of bubble trapping in this case is the direct absorption of light by the solution containing a dye. Due to heat release, fluid whirls propelled by the surface Marangoni effect at the liquid/gas interface emerge and extend to large distances. We report the experimental microscopic observation of the origin of whirls at an initially flat liquid/air interface as well as at the curved interface of a liquid/gas bubble and support this finding with advanced numerical simulations using the finite element method within the COMSOL Multiphysics platform...
July 11, 2017: Physical Chemistry Chemical Physics: PCCP
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