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Heat related emergencies

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https://www.readbyqxmd.com/read/28525284/intrinsically-disordered-proteins-as-important-players-during-desiccation-stress-of-the-soybean-radicles
#1
Yun Liu, Jiahui Wu, Nan Sun, Chengjian Tu, Xiaoying Shi, Hua Cheng, Simu Liu, Shuiming Li, Yong Wang, Yizhi Zheng, Vladimir N Uversky
Intrinsically disordered proteins (IDPs) play a variety of important physiological roles in all living organisms. However, there is no comprehensive analysis of the abundance of IDPs associated with environmental stress in plants. Here, we show that a set of heat-stable proteins (i.e., proteins that do not denature after boiling at 100°C for 10 min) was present in R0mm and R15mm radicles (i.e., before the radicle emergence and the 15 mm long radicles) of soybean (Glycine max) seeds. This set of 795 iTRAQ-quantified heat-stable proteins contained a high proportion of wholly or highly disordered proteins (15%), which was significantly higher than that estimated for the whole soybean proteome containing 55,787 proteins (9%)...
May 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28520817/heat-in-the-southeastern-united-states-characteristics-trends-and-potential-health-impact
#2
Jeremy E Diem, Christine E Stauber, Richard Rothenberg
High summer temperatures in extratropical areas have an impact on the public's health, mainly through heat stress, high air pollution concentrations, and the transmission of tropical diseases. The purpose of this study is to examine the current characteristics of heat events and future projections of summer apparent temperature (AT)-and associated health concerns-throughout the southeastern United States. Synoptic climatology was used to assess the atmospheric characteristics of extreme heat days (EHDs) from 1979-2015...
2017: PloS One
https://www.readbyqxmd.com/read/28505754/generalized-balance-equations-for-charged-particle-transport-via-localized-and-delocalized-states-mobility-generalized-einstein-relations-and-fractional-transport
#3
Peter W Stokes, Bronson Philippa, Daniel Cocks, Ronald D White
A generalized phase-space kinetic Boltzmann equation for highly nonequilibrium charged particle transport via localized and delocalized states is used to develop continuity, momentum, and energy balance equations, accounting explicitly for scattering, trapping and detrapping, and recombination loss processes. Analytic expressions detail the effect of these microscopic processes on mobility and diffusivity. Generalized Einstein relations (GER) are developed that enable the anisotropic nature of diffusion to be determined in terms of the measured field dependence of the mobility...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28503805/development-of-a-siyalon-glaze-for-improved-osteoconductivity-of-implantable-medical-devices
#4
Ryan M Bock, Elia Marin, Alfredo Rondinella, Francesco Boschetto, Tetsuya Adachi, Bryan J McEntire, B Sonny Bal, Giuseppe Pezzotti
The application of bioactive coatings onto orthopaedic appliances is commonly performed to compensate for the otherwise bioinert nature of medical devices and to improve their osseointegration. Calcium phosphates, hydroxyapatite (HAp), and bioglasses are commercially available for this purpose. Until recently, few other inorganic compounds have been identified with similar biofunctionality. However, silicon nitride (Si3 N4 ) has emerged as a new orthopaedic material whose unique surface chemistry also enhances osteoconductivity...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28499499/heat-related-morbidity-and-mortality-in-new-england-evidence-for-local-policy
#5
Gregory A Wellenius, Melissa N Eliot, Kathleen F Bush, Dennis Holt, Rebecca A Lincoln, Andrew E Smith, Julia Gold
BACKGROUND: Heat-related morbidity and mortality is a recognized public health concern. However, public health officials need to base policy decisions on local evidence, which is often lacking for smaller communities. OBJECTIVES: To evaluate the association between maximum daily heat index (HI) and morbidity and mortality in 15 New England communities (combined population: 2.7 million) in order to provide actionable evidence for local officials. METHODS: We applied overdispersed Poisson nonlinear distributed lag models to evaluate the association between HI and daily (May-September) emergency department (ED) admissions and deaths in each of 15 study sites in New Hampshire, Maine, and Rhode Island, controlling for time trends, day of week, and federal holidays...
March 25, 2017: Environmental Research
https://www.readbyqxmd.com/read/28447447/nuclear-targeting-gold-nanorods-for-extremely-low-nir-activated-photothermal-therapy
#6
Limin Pan, Jianan Liu, Jianlin Shi
Photorelated nanomedicine is of particular interest as an emerging paradigm toward precise cancer therapy, as demonstrated by recent developments of photothermal therapy (PTT), an emerging technique employing light-converting agents to burn cancerous cells by overdosed optical energy-converted heat. However, most of the laser irradiations needed for effective PTT significantly exceed the maximal permissible power density in human skin, which is likely to damage surrounding normal tissues. Herein, we report a strategy of intranuclear PTT of cancer enabled by nuclear-targeted delivery of gold nanorods of ∼10...
May 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28437773/are-hospital-emergency-department-visits-due-to-dog-bites-associated-with-ambient-temperature-a-time-series-study-in-beijing-china
#7
Yongming Zhang, Qi Zhao, Wenyi Zhang, Shanshan Li, Gongbo Chen, Zhihai Han, Yuming Guo
BACKGROUND: It is well documented that suboptimal ambient temperature is associated with cardiovascular and respiratory diseases. However, no study has examined the relation between temperature and dog bites. OBJECTIVES: To study the association between ambient temperature and daily hospital emergency department visits due to dog bites (EDVDBs) in Beijing, China; and to explore whether the temperature-EDVDB association varies by sex and age. METHODS: Daily EDVDBs were collected from a hospital appointed for dog bites in Beijing during 2012-2014...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28426518/pathophysiologic-insight-into-mesoamerican-nephropathy
#8
Magdalena Madero, Fernando E García-Arroyo, Laura-Gabriela Sánchez-Lozada
PURPOSE OF REVIEW: Mesoamerican nephropathy (MeN) is an emerging pathophysiological entity of Chronic kidney desease (CKD) not related to traditional risk factors (diabetes and hypertension) that have caused thousands of deaths in Central America, mainly in sugarcane workers. The focus of this review is to discuss the risk factors and probable mechanisms involved in the initiation and progression of this devastating disease. RECENT FINDINGS: Frequent episodes of subclinical Acute kidney injury caused by repetitive heat stress, dehydration, and strenuous work have been regarded as the main risk factors for MeN...
April 19, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28421177/variation-in-population-vulnerability-to-heat-wave-in-western-australia
#9
Jianguo Xiao, Tony Spicer, Le Jian, Grace Yajuan Yun, Changying Shao, John Nairn, Robert J B Fawcett, Andrew Robertson, Tarun Stephen Weeramanthri
Heat waves (HWs) have killed more people in Australia than all other natural hazards combined. Climate change is expected to increase the frequency, duration, and intensity of HWs and leads to a doubling of heat-related deaths over the next 40 years. Despite being a significant public health issue, HWs do not attract the same level of attention from researchers, policy makers, and emergency management agencies compared to other natural hazards. The purpose of the study was to identify risk factors that might lead to population vulnerability to HW in Western Australia (WA)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28394746/stochasticity-among-antibiotic-resistance-profiles-of-common-burn-related-pathogens-over-a-six-year-period
#10
Zachary J Collier, Lawrence J Gottlieb, John C Alverdy
BACKGROUND: One of the most significant contributors to morbidity and death in patients with burns is infection, which accounts for 30%-75% of post-burn fatalities. Because of concerns for the development of antibiotic resistance in burn-related pathogens, the aims of this study were to identify antibiotic resistance trends for the four most common burn-related pathogens over a six-year period. PATIENTS AND METHODS: The study used prospectively collected and de-identified aggregate data for all burn patients admitted to the burn unit between 2009 and 2014...
April 2017: Surgical Infections
https://www.readbyqxmd.com/read/28389052/dry-anaerobic-digestion-of-cow-manure-and-agricultural-products-in-a-full-scale-plant-efficiency-and-comparison-with-wet-fermentation
#11
Alessandro Chiumenti, Francesco da Borso, Sonia Limina
For years, anaerobic digestion processes have been implemented for the management of organic wastes, agricultural residues, and animal manure. Wet anaerobic digestion still represents the most common technology, while dry fermentation, dedicated to the treatment of solid inputs (TS>20%) can be considered as an emerging technology, not in terms of technological maturity, but of diffusion. The first agricultural dry anaerobic digestion plant constructed in Italy was monitored from the start-up, for over a year...
April 4, 2017: Waste Management
https://www.readbyqxmd.com/read/28379784/evaluation-of-diagnostic-codes-in-morbidity-and-mortality-data-sources-for-heat-related-illness-surveillance
#12
Laurel Harduar Morano, Sharon Watkins
OBJECTIVES: The primary objective of this study was to identify patients with heat-related illness (HRI) using codes for heat-related injury diagnosis and external cause of injury in 3 administrative data sets: emergency department (ED) visit records, hospital discharge records, and death certificates. METHODS: We obtained data on ED visits, hospitalizations, and deaths for Florida residents for May 1 through October 31, 2005-2012. To identify patients with HRI, we used codes from the International Classification of Diseases, Ninth Revision, Clinical Modification ( ICD-9-CM) to search data on ED visits and hospitalizations and codes from the International Classification of Diseases, Tenth Revision ( ICD-10) to search data on deaths...
May 2017: Public Health Reports
https://www.readbyqxmd.com/read/28362854/molecular-and-cellular-responses-of-the-pathogenic-fungus-lomentospora-prolificans-to-the-antifungal-drug-voriconazole
#13
Aize Pellon, Andoni Ramirez-Garcia, Idoia Buldain, Aitziber Antoran, Aitor Rementeria, Fernando L Hernando
The filamentous fungus Lomentospora (Scedosporium) prolificans is an emerging opportunistic pathogen associated with fatal infections in patients with disturbed immune function. Unfortunately, conventional therapies are hardly of any use against this fungus due to its intrinsic resistance. Therefore, we performed an integrated study of the L. prolificans responses to the first option to treat these mycoses, namely voriconazole, with the aim of unveiling mechanisms involved in the resistance to this compound...
2017: PloS One
https://www.readbyqxmd.com/read/28352286/an-approach-to-developing-local-climate-change-environmental-public-health-indicators-in-a-rural-district
#14
REVIEW
Adele Houghton, Jessica Austin, Abby Beerman, Clayton Horton
Climate change represents a significant and growing threat to population health. Rural areas face unique challenges, such as high rates of vulnerable populations; economic uncertainty due to their reliance on industries that are vulnerable to climate change; less resilient infrastructure; and lower levels of access to community and emergency services than urban areas. This article fills a gap in public health practice by developing climate and health environmental public health indicators for a local public health department in a rural area...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28342386/association-between-environmental-factors-and-emergency-hospital-admissions-due-to-alzheimer-s-disease-in-madrid
#15
D R Culqui, C Linares, C Ortiz, R Carmona, J Díaz
INTRODUCTION: There are scarce studies of time series that analysed the short-term association between emergency hospital admissions due to Alzheimer's disease (AD) and environmental factors. The objective is to analyse the effect of heat waves, noise and air pollutants on urgent hospital admissions due to AD in Madrid. METHODS: Longitudinal ecological time series study was performed. The dependent variable was the emergency AD hospital admissions occurred in Madrid during the period 2001-2009...
March 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28315949/-89-zr-onartuzumab-pet-imaging-of-c-met-receptor-dynamics
#16
Martin Pool, Anton G T Terwisscha van Scheltinga, Arjan Kol, Danique Giesen, Elisabeth G E de Vries, Marjolijn N Lub-de Hooge
PURPOSE: c-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug efficacy or emergence of resistance. Noninvasive visualization of c-MET dynamics could therefore potentially guide c-MET-directed therapies. We investigated the feasibility of (89)Zr-labelled one-armed c-MET antibody onartuzumab PET for detecting relevant changes in c-MET levels induced by c-MET-mediated epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib resistance or heat shock protein-90 (HSP90) inhibitor NVP-AUY-922 treatment in human non-small-cell lung cancer (NSCLC) xenografts...
March 19, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28314926/american-football-and-fatal-exertional-heat-stroke-a-case-study-of-korey-stringer
#17
Andrew Grundstein, John A Knox, Jennifer Vanos, Earl R Cooper, Douglas J Casa
On August 1, 2001, Korey Stringer, a Pro Bowl offensive tackle for the Minnesota Vikings, became the first and to date the only professional American football player to die from exertional heat stroke (EHS). The death helped raise awareness of the dangers of exertional heat illnesses in athletes and prompted the development of heat safety policies at the professional, collegiate, and interscholastic levels. Despite the public awareness of this death, no published study has examined in detail the circumstances surrounding Stringer's fatal EHS...
March 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28301350/a-phase-ii-study-of-ganetespib-as-second-line-or-third-line-therapy-for-metastatic-pancreatic-cancer
#18
Dana B Cardin, Ramya Thota, Laura W Goff, Jordan D Berlin, Clyde M Jones, Gregory D Ayers, Jennifer G Whisenant, Emily Chan
OBJECTIVES: Heat shock protein 90 regulates multiple signaling proteins involved in key pathways of pancreatic cancer pathogenesis. Ganetespib binds to heat shock protein 90 and interferes with its binding to client proteins thus leading to inactivation and degradation of the signaling proteins that promote cancer progression. This phase II study was designed to evaluate the efficacy of ganetespib in patients with refractory metastatic pancreatic cancer (rMPC). METHODS: Patients with rMPC received 175 mg/m ganetespib intravenously once weekly for 3 weeks in 4-week cycles...
March 15, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28300610/changes-in-microrna-abundance-may-regulate-diapause-in-the-flesh-fly-sarcophaga-bullata
#19
Julie A Reynolds, Justin T Peyton, David L Denlinger
Diapause, an alternative developmental pathway characterized by changes in developmental timing and metabolism, is coordinated by molecular mechanisms that are not completely understood. MicroRNA (miRNA) mediated gene silencing is emerging as a key component of animal development and may have a significant role in initiating, maintaining, and terminating insect diapause. In the present study, we test this possibility by using high-throughput sequencing and qRT-PCR to discover diapause-related shifts in miRNA abundance in the flesh fly, Sarcophaga bullata...
May 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28282618/integrating-multiple-stressors-across-life-stages-and-latitudes-combined-and-delayed-effects-of-an-egg-heat-wave-and-larval-pesticide-exposure-in-a-damselfly
#20
Szymon Sniegula, Lizanne Janssens, Robby Stoks
To understand the effects of pollutants in a changing world we need multistressor studies that combine pollutants with other stressors associated with global change such as heat waves. We tested for the delayed and combined impact of a heat wave during the egg stage and subsequent sublethal exposure to the pesticide esfenvalerate during the larval stage on life history and physiology in the larval and adult stage of the damselfly Lestes sponsa. We studied this in a common garden experiment with replicated central- and high latitude populations to explore potential effects of local thermal adaptation and differences in life history shaping the multistressor responses...
March 1, 2017: Aquatic Toxicology
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