keyword
MENU ▼
Read by QxMD icon Read
search

aggregation

keyword
https://www.readbyqxmd.com/read/28749601/chiral-recognition-system-orchestrated-by-self-assembly-a-cascade-of-molecular-chirality-self-assembly-morphology-fluorescence-response
#1
Takao Noguchi, Seiji Shinkai
The newly developed oligophenylenevinylene (OPV)-based fluorescent (FL) chiral chemosensor (OPV-Me) for the representative enantiomeric guest, 1,2-cyclohexanedicarboxylic acid (1,2-CHDA: RR- and SS-form) showed the high chiral discrimination ability, resulting in the different aggregation modes of OPV-Me self-assembly: RR-CHDA directed the fibrous supramolecular aggregate, whereas SS-CHDA directed the finite aggregate. The consequent FL intensity toward RR-CHDA was maximum 30 times larger than that toward SS-CHDA...
July 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28749565/melatonin-suppresses-platelet-activation-and-function-against-cardiac-ischemia-reperfusion-injury-via-ppar%C3%AE-fundc1-mitophagy-pathways
#2
Hao Zhou, Dandan Li, Pingjun Zhu, Shunying Hu, Nan Hu, Sai Ma, Ying Zhang, Tianwen Han, Jun Ren, Feng Cao, Yundai Chen
Platelet activation is a major (patho-) physiological mechanism that underlies ischemia/reperfusion (I/R) injury. In this study, we explored the molecular signals for platelet hyperactivity and investigated the beneficial effects of melatonin on platelet reactivity in response to I/R injury. After reperfusion, peroxisome proliferator-activated receptor γ (PPARγ) was progressively downregulated in patients with acute myocardial infarction undergoing coronary artery bypass grafting (CABG) surgery and in mice with I/R injury model...
July 27, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28749494/two-intensified-fluorescence-colors-switching-achieved-by-branched-dye-nanoaggregates
#3
Ge Ding, Yao Lu, Jihong Su, Xiaozhuan Qin, Ziping Luo, Fang Gao, Lingyun Chen, Hongru Li
In this study, a variety of branched target dyes containing double internal proton transfer segments were synthesized. For comparison, some linear analogs including a single internal proton transfer part were synthesized. The corresponding reference molecules lacking proton transfer segments were also prepared. The properties and aggregation modes of these dye aggregates were investigated on the basis of scanning electron microscopy images, transmission electron microscopy images, dynamic light scattering, X-ray diffraction, UV/visible absorption spectra and fluorescence emission spectra...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749490/evidence-for-cooperative-na-and-cl-binding-by-strongly-hydrated-l-proline
#4
Olga A Dmitrieva, Marina V Fedotova, Richard Buchner
In nature the amino acid l-proline (Pro) is a ubiquitous and highly effective osmolyte protecting cells against osmotic stress. To understand this effect knowledge of the hydration of Pro and its interactions with dissolved salts is essential. We studied these properties by combining statistical mechanics and broadband dielectric spectroscopy and found that Pro remains strongly hydrated up to high amino-acid concentrations. This is also the case upon NaCl addition to a 0.6 M Pro solution. Here, additionally a Pro·NaCl aggregate is formed with a stability constant of K° ≈ 0...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749143/self-assembly-of-escin-molecules-at-the-air-water-interface-studied-by-molecular-dynamics
#5
Sonya Rusiyanova Tsibranska, Anela Ivanova, Slavka Tcholakova, Nikolai D Denkov
Escin belongs to a large class of natural bio-surfactants, called saponins, which are present in more than 500 plant species. Saponins are applied in pharmaceutical, cosmetic, food and beverage industries, due to their variously expressed bioactivity and surface activity. In particular, Escin adsorption layers at the air-water interface exhibit unusually high surface elastic modulus (> 1100 mN/m) and high surface viscosity (ca. 130 N.s/m). The molecular origin of these unusual surface rheological properties is still unclear...
July 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28749141/aggregation-and-solvation-of-n-butyllithium
#6
Onkei Tai, Russell Hopson, Paul G Williard
Solution characterizations and ligand binding constants were determined for n-butyllithium in hydrocarbon and ethereal solvents using diffusion-ordered NMR. In hydrocarbon solvents, n-butyllithium exists primarily as an octamer at -40 °C and deaggregates to a hexamer when the temperature is increased. In the presence of THF or diethyl ether, n-butyllithium exists predominantly as a tetra-solvated tetramer and deaggregates to a tetra-solvated dimer in the presence of a large excess or neat THF. The ligand binding constants for the tetra-solvated tetramers were measured using (1)H NMR/DOSY titration...
July 27, 2017: Organic Letters
https://www.readbyqxmd.com/read/28749049/mineral-trioxide-aggregate-enhances-the-osteogenic-capacity-of-periodontal-ligament-stem-cells-via-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#7
Yanqiu Wang, Yixiang Zhou, Lin Jin, Xiyao Pang, Yadie Lu, Zilu Wang, Yan Yu, Jinhua Yu
INTRODUCTION: Mineral trioxide aggregate (MTA), as a bioactive material, has a widespread application in clinical practice. To date, the effects of MTA on the proliferation and differentiation of human periodontal ligament stem cells (hPDLSCs) remain unclear. MATERIALS AND METHODS: hPDLSCs were isolated from human periodontal ligament tissues and cultured with MTA conditioned media. Cell counting kit-8 (CCK-8) assay was performed to assess the proliferation capacity of MTA-treated hPDLSCs...
July 27, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28748639/how-nurses-cope-with-patient-death-a-systematic-review-and-qualitative-meta-synthesis
#8
REVIEW
Ruishuang Zheng, Susan Fiona Lee, Melissa Jane Bloomer
AIMS AND OBJECTIVES: To review literature on nurses' coping strategies with patient death. BACKGROUND: dealing with the loss of a patient was viewed as one of the most demanding and challenging encounters in clinical practice. Those nurses who are not competent in coping with patient death may be inadequate in supporting dying patients and their family members, and minimize the quality of end-of-life care. To get a broader understanding of how nurses cope with patient death and to develop meaningful and effective interventions, a systematic review which would help underpin the multidimensional approaches is needed...
July 26, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28748527/the-prevalence-of-dicer1-pathogenic-variation-in-population-databases
#9
Jung Kim, Amanda Field, Kris Ann P Schultz, D Ashley Hill, Douglas R Stewart
The DICER1 syndrome is associated with a variety of rare benign and malignant tumors, including pleuropulmonary blastoma (PPB), cystic nephroma (CN) and Sertoli-Leydig cell tumor (SLCT). The prevalence and penetrance of pathogenic DICER1 variation in the general population is unknown. We examined three publicly-available germline whole exome sequence datasets: Exome Aggregation Consortium (ExAC), 1000 Genomes (1000G), and the Exome Sequencing Project (ESP). To avoid over-estimation of pathogenic DICER1 variation from cancer-associated exomes, we excluded The Cancer Genome Atlas (TCGA) variants from ExAC...
July 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28748508/autophagy-enhancement-is-rendered-ineffective-in-presence-of-%C3%AE-synuclein-in-melanoma-cells
#10
Swapna Nandakumar, Bejoy Vijayan, Asha Kishore, Anoopkumar Thekkuveettil
Increased cellular concentration of α-synuclein (α-syn) predisposes it to misfolding and aggregation that in turn impair the degradation pathways. This poses a limitation to the use of overexpression models for studies on α-syn clearance by autophagy, which is widely investigated for its therapeutic potential. This limitation can be overcome with the use of endogenous models. In this study, SK-MEL-28, a melanoma cell model with endogenous α-syn expression, was employed to study α-syn clearance through autophagy...
July 26, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28748441/ozone-risk-assessment-in-three-oak-species-as-affected-by-soil-water-availability
#11
Yasutomo Hoshika, Barbara Moura, Elena Paoletti
To derive ozone (O3) dose-response relationships for three European oak species (Quercus ilex, Quercus pubescens, and Quercus robur) under a range of soil water availability, an experiment was carried out with 2-year-old potted seedlings exposed to three levels of water availability in the soil and three levels of O3 pollution for one growing season in an ozone free-air controlled exposure (FACE) facility. Total biomass losses were estimated relative to a hypothetical clean air at the pre-industrial age, i...
July 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28748367/commercial-online-social-network-data-and-statin-side-effect-surveillance-a-pilot-observational-study-of-aggregate-mentions-on-facebook
#12
Marco D Huesch
INTRODUCTION: Surveillance of the safety of prescribed drugs after marketing approval has been secured remains fraught with complications. Formal ascertainment by providers and reporting to adverse-event registries, formal surveys by manufacturers, and mining of electronic medical records are all well-known approaches with varying degrees of difficulty, cost, and success. Novel approaches may be a useful adjunct, especially approaches that mine or sample internet-based methods such as online social networks...
July 26, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28748286/normalized-levels-of-red-blood-cells-expressing-phosphatidylserine-their-microparticles-and-activated-platelets-in-young-patients-with-%C3%AE-thalassemia-following-bone-marrow-transplantation
#13
Phatchanat Klaihmon, Sinmanus Vimonpatranon, Egarit Noulsri, Surapong Lertthammakiat, Usanarat Anurathapan, Nongnuch Sirachainan, Suradej Hongeng, Kovit Pattanapanyasat
Bone marrow transplantation (BMT) serves as the only curative treatment for patients with β-thalassemia major; however, hemostatic changes have been observed in these BMT patients. Aggregability of thalassemic red blood cells (RBCs) and increased red blood cell-derived microparticles (RMPs) expressing phosphatidylserine (PS) are thought to participate in thromboembolic events by initially triggering platelet activation. To our knowledge, there has been no report providing quantitation of these circulating PS-expressing RBCs and RMPs in young β-thalassemia patients after BMT...
July 26, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28748091/the-tetravalent-formulation-of-domain-iii-capsid-proteins-recalls-memory-b-and-t-cell-responses-induced-in-monkeys-by-an-experimental-dengue-virus-infection
#14
Lázaro Gil, Laura Lazo, Iris Valdés, Edith Suzarte, Phuong Yen, Rosa Ramírez, Mayling Álvarez, Le T Dung, Karem Cobas, Ernesto Marcos, Yusleidi Pérez, María G Guzmán, Ngyen D Hien, Gerardo Guillén, Lisset Hermida
Tetra DIIIC is a vaccine candidate against dengue virus (DENV) composed by four chimeric proteins that fuse the domain III of the envelope protein of each virus to the corresponding capsid protein. Containing B- and T-cell epitopes, these proteins form aggregates after the incubation with an immunostimulatory oligodeoxynucleotide, and their tetravalent formulation induces neutralizing antibodies and cellular immune response in mice and monkeys. Also, Tetra DIIIC protects mice after challenge with each DENV, and the monovalent formulation obtained from DENV-2 protects monkeys upon homologous viral challenge...
June 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28748048/effect-of-different-mixing-methods-on-the-bacterial-microleakage-of-white-portland-cement-and-white-mineral-trioxide-aggregate
#15
Shahriar Shahi, Asmar Bashirzadeh, Hamid Reza Yavari, Farnaz Jafari, Amin Salem Milani, Negin Ghasemi, Mohammad Samiei
Background. of this study was to investigate the effect of different mixing methods (ultrasonic, amalgamator, and conventional) on the bacterial microleakage of white Portland cement (WPC) and white MTA (Tooth-colored Formula, Dentsply, Tulsa Dental, Tulsa, OK). Methods. A hundred human single-rooted permanent teeth were decoronated to obtain 14 mm of root length in all the samples. The root canals were cleaned, shaped and obturated. Three millimeters of each root apex were cut off and randomly divided into 6 groups of 15 each (3 groups for WMTA and 3 groups for WPC, each with 3 different mixing methods) and 2 positive and negative control groups (each containing 5 samples)...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28748003/patient-attitudes-towards-community-based-tuberculosis-dot-and-adherence-to-treatment-in-an-urban-setting-kampala-uganda
#16
Sempeera Hassard, Anguzu Ronald, Kawooya Angella
INTRODUCTION: High Tuberculosis treatment default rate (17%) and sub-optimal treatment completion rates (45%) has burdened Kampala. Nevertheless, there are observable increase in the number of patients on TB DOT; from 6% to 29% in two consecutive annual reports. The main objective was to determine the association of TB patient attitudes towards community-based observers on the TB drug adherence on directly observed treatment for TB in Kampala. METHODS: A cross-sectional study was carried out in Lubaga division, Kampala...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28747975/blood-flow-improving-activity-of-methyl-jasmonate-treated-adventitious-roots-of-mountain-ginseng
#17
Young-Hwan Ban, Yeseul Cha, Jieun Choi, Eun Suk An, Ji Young Lee, Nu Ry Han, Da Woom Seo, Gooyoung Jung, Da-Hye Jeong, Man Hee Rhee, Ehn-Kyoung Choi, Yun-Bae Kim
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747893/the-indecision-model-of-psychophysical-performance-in-dual-presentation-tasks-parameter-estimation-and-comparative-analysis-of-response-formats
#18
Miguel A García-Pérez, Rocío Alcalá-Quintana
Psychophysical data from dual-presentation tasks are often collected with the two-alternative forced-choice (2AFC) response format, asking observers to guess when uncertain. For an analytical description of performance, psychometric functions are then fitted to data aggregated across the two orders/positions in which stimuli were presented. Yet, order effects make aggregated data uninterpretable, and the bias with which observers guess when uncertain precludes separating sensory from decisional components of performance...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28747872/l-3-n-butylphthalide-protects-hspb8-k141n-mutation-induced-oxidative-stress-by-modulating-the-mitochondrial-apoptotic-and-nrf2-pathways
#19
Xiao-Dong Yang, Zhi-Dong Cen, Hai-Peng Cheng, Kai Shi, Jie Bai, Fei Xie, Hong-Wei Wu, Bei-Bei Li, Wei Luo
Charcot-Marie-Tooth disease (CMT), also known as hereditary motor and sensory neuropathy, is the most common inherited peripheral nerve disorder. Missense mutations, such as K141N, in the small heat shock protein HSPB8 are known to cause distal hereditary motor neuropathy 2A (dHMN2A) or Charcot-Marie-Tooth neuropathy type 2L (CMT2L). However, of critical clinical significance, very few specific therapies for this disease exist. In the present study, we investigated the impact of mutant K141N HSPB8 on mitochondrial distribution and function in a cellular model of CMT2L...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28747810/differences-in-social-preference-between-the-sexes-during-ontogeny-drive-segregation-in-a-precocial-species
#20
Mark A Whiteside, Jayden O van Horik, Ellis J G Langley, Christine E Beardsworth, Philippa R Laker, Joah R Madden
ABSTRACT: Hypotheses for why animals sexually segregate typically rely on adult traits, such as differences in sexual roles causing differential habitat preferences, or size dimorphism inducing differences in diet or behaviour. However, segregation can occur in juveniles before such roles or size dimorphism is well established. In young humans, leading hypotheses suggest that (1) sexes differ in their activity and the synchronisation of behaviour causes segregation and (2) sexes separate in order to learn and maximise future reproductive roles...
2017: Behavioral Ecology and Sociobiology
keyword
keyword
18556
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"