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https://www.readbyqxmd.com/read/28938767/isothermal-gelation-behavior-of-myofibrillar-proteins-from-white-and-red-chicken-meat-at-different-temperatures
#1
S Glorieux, L Steen, H Paelinck, I Foubert, I Fraeye
This paper provides insights in the isothermal gelation behavior of white and red chicken myofibrillar proteins (CMP) at different temperatures (20 to 80°C) and the underlying aggregation mechanism, allowing understanding of structure formation in poultry products during thermal processing. At low temperatures (20 to 60°C), an increase in aromatic surface hydrophobicity (SoANS) was found, suggesting potential formation of hydrophobic interactions between CMP. At higher temperatures (60 to 80°C), high SoANS and a significant decrease in total sulfhydryl amount (SH-amount) strongly indicate the presence of hydrophobic interactions and disulfide bonding, resulting in aggregation, as suggested by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE)...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938559/doxorubicin-loaded-platelets-conjugated-with-anti-cd22-mabs-a-novel-targeted-delivery-system-for-lymphoma-treatment-with-cardiopulmonary-avoidance
#2
Peipei Xu, Huaqin Zuo, Rongfu Zhou, Fan Wang, Xu Liu, Jian Ouyang, Bing Chen
B-cell lymphoma accounts for approximately 85% of all adult non-Hodgkin's lymphoma cases. Doxorubicin (DOX) is an indispensable drug for the treatment of non-Hodgkin's lymphoma. However, DOX causes severe cardiotoxicity, which limits its use in conventional treatment strategies. In this study, we developed a novel drug delivery system for lymphoma treatment: DOX-loaded platelets that were conjugated with anti-CD22 monoclonal antibodies (mAbs) (DOX-platelet-CD22). Platelets are bio- and immune-compatible drug carriers that can prolong the circulation time of drugs...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938209/interactions-between-biogenic-selenium-nanoparticles-and-goethite-colloids-and-consequence-for-remediation-of-elemental-mercury-contaminated-groundwater
#3
Xiaonan Wang, Daoyong Zhang, Haifeng Qian, Yan Liang, Xiangliang Pan, Geoffrey Michael Gadd
Ubiquitous colloidal minerals such as goethite can have a significant impact on the performance of nanoparticles-based groundwater remediation due to aggregation. Heteroaggregation and retention of Se nanoparticles (SeNPs) by goethite in groundwater, and its impact on Hg(0) remediation by SeNPs were investigated in this study. In order to mitigate the adverse effects of aggregation, the effects of bacterial extracellular polymeric substances (EPS) on the stability of SeNPs and Hg(0) sequestration using SeNPs were also evaluated...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938121/huntingtin-fibrils-poke-membranes
#4
Pedro Guedes-Dias, Erika L F Holzbaur
A hallmark of Huntington's disease is the presence of intracellular aggregates of mutant huntingtin, the pathological significance of which has long been debated. Using cryo-electron tomography, Bauerlein et al. reveal the fibrillary structure of huntingtin aggregates in situ and show that huntingtin fibrils interact with the endoplasmic reticulum, distorting its morphology and dynamics.
September 21, 2017: Cell
https://www.readbyqxmd.com/read/28938031/evaluation-of-a-titanium-surface-treated-with-hydroxyapatite-nanocrystals-on-osteoblastic-cell-behavior-an-in-vitro-study
#5
Elizabeth Ferreira Martinez, Guilherme Junji Ishikawa, Alexandre Barboza de Lemos, Fábio José Barbosa Bezerra, Marcelo Sperandio, Marcelo Henrique Napimoga
PURPOSE: In the context of macrostructural and microstructural modifications to the design of dental implants, surface topography changes with different treatments have the purpose of accelerating bone formation. The aim of this study was to evaluate in vitro the influence of aggregated hydroxyapatite nanocrystals to surfaces treated with double acid etching (Nano) on osteoblastic cell behavior compared with a conventional double acid-etched surface (DE). MATERIALS AND METHODS: Commercially pure Grade 4 titanium discs (6 × 2 mm) were selected, and both cell proliferation and viability were assessed at 24, 48, and 72 hours using Trypan blue vital dye and MTT, respectively...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28937985/interference-with-plastome-gene-expression-and-clp-protease-activity-in-arabidopsis-triggers-a-chloroplast-unfolded-protein-response-to-restore-protein-homeostasis
#6
Ernesto Llamas, Pablo Pulido, Manuel Rodriguez-Concepcion
Disruption of protein homeostasis in chloroplasts impairs the correct functioning of essential metabolic pathways, including the methylerythritol 4-phosphate (MEP) pathway for the production of plastidial isoprenoids involved in photosynthesis and growth. We previously found that misfolded and aggregated forms of the first enzyme of the MEP pathway are degraded by the Clp protease with the involvement of Hsp70 and Hsp100/ClpC1 chaperones in Arabidopsis thaliana. By contrast, the combined unfolding and disaggregating actions of Hsp70 and Hsp100/ClpB3 chaperones allow solubilization and hence reactivation of the enzyme...
September 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28937907/direct-pulp-capping-in-primary-molars-using-mineral-trioxide-aggregate-an-in-vivo-study
#7
Elzbieta Luczaj-Cepowicz, Grazyna Marczuk-Kolada, Malgorzata Pawinska, Marta Obidzinska
OBJECTIVE: To do a clinical and radiographic evaluation of the effectiveness of MTA when used as a direct pulp capping material in primary molars. STUDY DESIGN: Clinical and radiographic follow-up was performed on 30 primary molars with deep caries lesions in 30 patients from 3 to 9.75 years of age. Pulps exposed during cavity preparation were treated by direct pulp capping with MTA. The follow-up clinical and radiographic examinations were carried out at different time intervals: 6, 7-12, 13-18, 19-24, and >24 months after treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937763/hybrid-cis-trans-tetra-arylethenes-with-switchable-aie-and-reversible-photochromism-in-the-solution-pmma-film-solid-powder-and-single-crystal
#8
Qianfu Luo, Fei Cao, Chaochao Xiong, Qingyu Dou, Da-Hui Qu
How to efficiently design and synthesize multifunctional molecules is particularly challenging. Here we devote to constructing a kind of simple structures with composite functionalities through straightforward preparation. Starting from common commercially available materials, the titled cis/ tans-tetraarylethenes can be conveniently obtained by one-pot under mild conditions. The different configurations were confirmed by 1H NMR and single crystal data analysis. The trans-tetraarylethenes could be converted into cis-forms not only by photo-irradiation but also by microwave irradiation, which provided us a new choice for isomeric conversion, especially for which sensitive to light...
September 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28937747/photo-and-electrocatalytic-hydrogen-production-using-valence-isomers-of-n2s2-type-nickel-complexes
#9
Satoshi Inoue, Manabu Mitsuhashi, Takeshi Ono, Yin-Nan Yan, Yusuke Kataoka, Makoto Handa, Tatsuya Kawamoto
Three Schiff-base-type nickel(II) complexes (1a-3a) and the corresponding noninnocent-type complexes (1b-3b) were synthesized, and the equilibria between these valence isomers were observed in tetrahydrofuran (THF) at room temperature. The electronic state of the noninnocent-type nickel complex was also confirmed by isolation of the one-electron-reduced species. The catalytic ability for the photogeneration of hydrogen from water was examined about 1a-3a and 1b-3b in the presence of a photosensitizer and a sacrificial electron donor...
September 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28937677/synthesis-and-materialization-of-a-reaction-diffusion-french-flag-pattern
#10
Anton S Zadorin, Yannick Rondelez, Guillaume Gines, Vadim Dilhas, Georg Urtel, Adrian Zambrano, Jean-Christophe Galas, André Estevez-Torres
During embryo development, patterns of protein concentration appear in response to morphogen gradients. These patterns provide spatial and chemical information that directs the fate of the underlying cells. Here, we emulate this process within non-living matter and demonstrate the autonomous structuration of a synthetic material. First, we use DNA-based reaction networks to synthesize a French flag, an archetypal pattern composed of three chemically distinct zones with sharp borders whose synthetic analogue has remained elusive...
October 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28937675/coherent-singlet-fission-activated-by-symmetry-breaking
#11
Kiyoshi Miyata, Yuki Kurashige, Kazuya Watanabe, Toshiki Sugimoto, Shota Takahashi, Shunsuke Tanaka, Jun Takeya, Takeshi Yanai, Yoshiyasu Matsumoto
Singlet fission, in which a singlet exciton is converted to two triplet excitons, is a process that could be beneficial in photovoltaic applications. A full understanding of the dynamics of singlet fission in molecular systems requires detailed knowledge of the relevant potential energy surfaces and their (conical) intersections. However, obtaining such information is a nontrivial task, particularly for molecular aggregates. Here we investigate singlet fission in rubrene crystals using transient absorption spectroscopy and state-of-the-art quantum chemical calculations...
October 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28937661/a-spectral-probe-for-detection-of-aluminum-iii-ions-using-surface-functionalized-gold-nanoparticles
#12
Surendra Shinde, Dae-Young Kim, Rijuta Ganesh Saratale, Asad Syed, Fuad Ameen, Gajanan Ghodake
A simple green route has been developed for the synthesis of casein peptide functionalized gold nanoparticles (AuNPs), in which casein peptide acts as a reducing as well as the stabilizing agent. In this report, AuNPs have been characterized on the basis of spectroscopic and microscopic results; which showed selective and sensitive response toward Al(3+) in aqueous media, and Al(3+) induces aggregation of AuNPs. The sensing study performed for Al(3+) revealed that the color change from red to blue was due to a red-shift in the surface plasmon resonance (SPR) band and the formation of aggregated species of AuNPs...
September 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28937634/the-physiological-and-pathological-implications-of-the-formation-of-hydrogels-with-a-specific-focus-on-amyloid-polypeptides
#13
REVIEW
Létitia Jean, Alex C Foley, David J T Vaux
Hydrogels are water-swollen and viscoelastic three-dimensional cross-linked polymeric network originating from monomer polymerisation. Hydrogel-forming polypeptides are widely found in nature and, at a cellular and organismal level, they provide a wide range of functions for the organism making them. Amyloid structures, arising from polypeptide aggregation, can be damaging or beneficial to different types of organisms. Although the best-known amyloids are those associated with human pathologies, this underlying structure is commonly used by higher eukaryotes to maintain normal cellular activities, and also by microbial communities to promote their survival and growth...
September 22, 2017: Biomolecules
https://www.readbyqxmd.com/read/28937603/proteome-stability-as-a-key-factor-of-genome-integrity
#14
REVIEW
Sentiljana Gumeni, Zoi Evangelakou, Vassilis G Gorgoulis, Ioannis P Trougakos
DNA damage is constantly produced by both endogenous and exogenous factors; DNA lesions then trigger the so-called DNA damaged response (DDR). This is a highly synchronized pathway that involves recognition, signaling and repair of the damage. Failure to eliminate DNA lesions is associated with genome instability, a driving force in tumorigenesis. Proteins carry out the vast majority of cellular functions and thus proteome quality control (PQC) is critical for the maintenance of cellular functionality. PQC is assured by the proteostasis network (PN), which under conditions of proteome instability address the triage decision of protein fold, hold, or degrade...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937218/role-of-calcium-in-the-coagulation-of-nom-with-ferric-chloride
#15
Christina C Davis, Marc A Edwards
Natural organic matter (NOM) is capable of interfering with Fe hydrolysis and influencing the size, morphology, and identity of Fe precipitates. Conversely, Ca(2+) raises surface potential and increases the size and aggregation of Fe precipitates, leading to more effective coagulation and widening the pH range of water treatment. Experiments and modeling were conducted to investigate the significance of the Fe/NOM ratio and the presence of Ca(2+) in coagulation. At the high Fe/NOM ratio, sufficient or excess Fe was available for NOM removal, and coagulation proceeded according to expectations based upon the literature...
September 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28937173/adsorption-of-molecular-hydrogen-on-coronene-with-a-new-potential-energy-surface
#16
Massimiliano Bartolomei, Ricardo Pérez de Tudela, Kilian Arteaga, Tomás González-Lezana, Marta I Hernández, José Campos-Martínez, Pablo Villarreal, Javier Hernández-Rojas, José Bretón, Fernando Pirani
Benchmark interaction energies between coronene, C24H12, and molecular hydrogen, H2, have been computed by means of high level electronic structure calculations. Binding energies, equilibrium distances and strengths of the long range attraction, evaluated for the basic configurations of the H2-C24H12 complex, indicate that the system is not too affected by the relative orientations of the diatom, suggesting that its behavior can be approximated to that of a pseudoatom. The obtained energy profiles have confirmed the noncovalent nature of the bonding and serve to tune-up the parameters of a new force field based on the atom-bond approach which correctly describes the main features of the H2-coronene interaction...
September 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28937170/photochemistry-and-aggregation-behavior-of-triethylene-glycol-teg-terminated-stilbene-dendrimers
#17
Hiroya Sakurai, Takashi Maruyama, Tatsuo Arai
The photochemical properties of stilbene cored amphiphilic dendrimers (G0-G3) in THF and water were investigated. The solvation dynamics in water depended on the generation, while the behavior is almost the same in THF. Dendrimers G1 and G2 form molecular assemblies and undergo photodimerization reaction in addition to photoisomerization. G3 has enough TEG groups on the surface to cover the hydrophobic moiety within a single molecule. These dendrimers have free space around the core to undergo mutual isomerization even in water...
September 22, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28937165/a-facile-solvent-mediated-self-assembly-silver-nanoparticle-mirror-substrate-for-quantitatively-improved-surface-enhanced-raman-scattering
#18
Yanqi Qu, Chen Tan, Zhiyun Zhang, Lili He
Herein, a facile solvent mediated silver nanoparticle (AgNP) mirror was introduced as a reproducible and sensitive surface-enhanced Raman scattering (SERS) substrate. The AgNP mirror was fabricated based on commercially available citrate coated AgNPs via a facile and unique water-solvent interface assembly method without using any electrical equipment. By adding 0.2 mg ml(-1) citrate coated AgNPs dropwise into a mediating solvent, self-assembled AgNP mirrors were formed instantly and gradually settled down at the bottom...
September 22, 2017: Analyst
https://www.readbyqxmd.com/read/28937157/mutual-interference-of-cu-and-zn-ions-in-alzheimer-s-disease-perspectives-at-the-molecular-level
#19
Elena Atrián-Blasco, Amandine Conte-Daban, Christelle Hureau
While metal ions such as copper and zinc are essential in biology, they are also linked to several amyloid-related diseases, including Alzheimer's disease (AD). Zinc and copper can indeed modify the aggregation pathways of the amyloid-β (Aβ) peptide, the key component encountered in AD. In addition, the redox active copper ions do produce Reactive Oxygen Species (ROS) when bound to the Aβ peptide. While Cu(i) or Cu(ii) or Zn(ii) coordination to the Aβ has been extensively studied in the last ten years, characterization of hetero-bimetallic Aβ complexes is still scarce...
September 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28936833/-mechanism-of-salvianolate-injection-combined-with-aspirin-in-treatment-of-stable-angina-pectoris-based-on-biomolecules-network
#20
Yuan Li, Lian-Xin Wang, Yan-Ming Xie
Biomolecular network analysis was used to predict the mechanism of Salvianolate injection combined with aspirin for the treatment of stable angina pectoris(SAP). Related genes of Salvianolate injection, aspirin and SAP were obtained from Genecards, STITCH and DisGeNET databases. Agilent literature search software was used to construct biomolecular network; modules were identified by AP, MCODE and MCL methods. DAVID software was used for identification of related KEGG pathways. Results showed that Salvianolate injection and aspirin had a coverage rate of 45...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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