keyword
https://read.qxmd.com/read/38492996/assessment-of-postmastectomy-radiation-therapy-receipt-by-age-and-association-with-outcomes-in-women-with-breast-cancer
#1
JOURNAL ARTICLE
Carolina E Fasola, Elaina Graham, Wei Sha, Courtney R Schepel, Sally J Trufan, Anna Hecksher, Richard L White, Lejla Hadzikadic-Gusic
PURPOSE: Postmastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and improves overall survival (OS) in patients with breast cancer. Young age has been recognized as a risk factor for LRR. The primary objective of this study was to determine if recommendations for PMRT differed among patients younger than 50 years as compared to women aged 50 years or older. METHODS: We reviewed medical records of patients with breast cancer who underwent mastectomy with or without PMRT from 2010 through 2018...
February 28, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38492276/platinum-chemotherapy-for-early-triple-negative-breast-cancer
#2
REVIEW
Sofia Re Mason, Melina L Willson, Sam J Egger, Jane Beith, Rachel F Dear, Annabel Goodwin
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with shorter survival and a higher likelihood of recurrence. In early TNBC, platinum chemotherapy has been shown to improve pathological complete response (pCR); however, its effect on long-term survival outcomes has not been fully elucidated. METHODS: Randomised controlled trials examining neoadjuvant or adjuvant platinum chemotherapy for early TNBC were included...
March 12, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38492259/oncologic-safety-of-breast-conserving-surgery-after-neoadjuvant-chemotherapy-in-patients-with-multiple-ipsilateral-breast-cancer-a-retrospective-multi-institutional-cohort-study
#3
JOURNAL ARTICLE
Élise Di Lena, Stephanie M Wong, Ericka Iny, Sarah Mashal, Mark Basik, Jean-François Boileau, Karyne Martel, Miranda Addie Bassel, Sarkis Meterissian, Ipshita Prakash
INTRODUCTION: The recent ACOSOG Z11102 trial demonstrated low recurrence rates with breast conserving surgery (BCS) in women with multiple ipsilateral breast cancers (MIBC). Questions remain regarding the oncologic safety of BCS in women with MIBC receiving neoadjuvant chemotherapy (NAC). METHODS: We conducted a retrospective cohort study of adult patients who underwent BCS following NAC for stage I-III breast cancer from 2012 to 2021 at two academic centers...
March 12, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38492205/liquid-biopsy-for-breast-cancer-and-other-solid-tumors-a-review-of-recent-advances
#4
JOURNAL ARTICLE
Hirofumi Ohmura, Fumiyasu Hanamura, Yuta Okumura, Yuki Ando, Takaaki Masuda, Koshi Mimori, Koichi Akashi, Eishi Baba
Liquid biopsy using circulating tumor DNA (ctDNA) has been reported to be less invasive and effective for comprehensive genetic analysis of heterogeneous solid tumors, including decision-making for therapeutic strategies, predicting recurrence, and detecting genetic factors related to treatment resistance in various types of cancers. Breast cancer, colorectal cancer, and lung cancer are among the most prevalent malignancies worldwide, and clinical studies of liquid biopsy for these cancers are ongoing. Liquid biopsy has been used as a companion diagnostic tool in clinical settings, and research findings have accumulated, especially in cases of colorectal cancer after curative resection and non-small cell lung cancer (NSCLC) after curative chemoradiotherapy, in which ctDNA detection helps predict eligibility for adjuvant chemotherapy...
March 16, 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/38491813/cardiovascular-anti-inflammatory-drugs-repurposed-for-treating-or-preventing-cancer-a-systematic-review-and-meta-analysis-of-randomized-trials
#5
JOURNAL ARTICLE
David J Benjamin, Alyson Haslam, Vinay Prasad
BACKGROUND: Due to encouraging pre-clinical data and supportive observational studies, there has been growing interest in applying cardiovascular drugs (including aspirin, angiotensin-converting enzyme [ACE] inhibitors, statins, and metformin) approved to treat diseases such as hypertension, hyperlipidemia, and diabetes mellitus to the field of oncology. Moreover, given growing costs with cancer care, these medications have offered a potentially more affordable avenue to treat or prevent recurrence of cancer...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491186/an-efficient-breast-cancer-classification-model-using-bilateral-filtering-and-fuzzy-convolutional-neural-network
#6
JOURNAL ARTICLE
A Abdul Hayum, J Jaya, R Sivakumar, B Paulchamy
BC (Breast cancer) is the second most common reason for women to die from cancer. Recent workintroduced a model for BC classifications where input breast images were pre-processed using median filters for reducing noises. Weighed KMC (K-Means clustering) is used to segment the ROI (Region of Interest) after the input image has been cleaned of noise. Block-based CDF (Centre Distance Function) and CDTM (Diagonal Texture Matrix)-based texture and shape descriptors are utilized for feature extraction. The collected features are reduced in counts using KPCA (Kernel Principal Component Analysis)...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38489298/a-randomised-controlled-trial-of-pre-operative-oncotype-dx-testing-in-early-stage-breast-cancer-pre-dx-study-study-protocol
#7
JOURNAL ARTICLE
Matthew Northgraves, Judith Cohen, James Harvey, Chao Huang, Carlo Palmieri, Sarah Pinder, Pankaj Roy, Sarah Reynia, Marta Soares, Henry Cain
BACKGROUND: The Oncotype DX® Breast Recurrence Score assay can guide recommendations made to patients with oestrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer regarding post-surgery adjuvant therapy. Standard practice is to order the test in the post-operative setting on a specimen from the excised invasive carcinoma. However, it has been shown to be technically possible to perform the test on the diagnostic core biopsy. By testing the diagnostic core biopsy in the pre-operative setting, the wait for excised invasive carcinoma Recurrence Score results could be reduced allowing patients to be more accurately counselled regarding their treatment pathway sooner with any adjuvant treatment recommendations expedited...
2024: PloS One
https://read.qxmd.com/read/38489166/use-of-axillary-ultrasound-to-guide-breast-cancer-management-in-the-genomic-assay-era
#8
JOURNAL ARTICLE
Geok Hoon Lim, John Carson Allen, Yien Sien Lee, Sze Yiun Teo, Li Ching Lau, Thida Win, Lester Chee Hao Leong
INTRODUCTION: Chemotherapy is conventionally offered to non-stage IV breast cancer patients with metastatic nodes. However, the RxPONDER trial showed that chemotherapy can be omitted in selected patients with 1-3 metastatic nodes if the 21-gene assay recurrence score is ≤25. We aimed to investigate if axillary ultrasound can identify this group of patients with limited nodal burden so that they can undergo upfront surgery followed by gene assay testing, to potentially avoid chemotherapy...
2024: Breast Disease
https://read.qxmd.com/read/38489090/a-case-of-bloom-syndrome-manifesting-with-therapy-related-myelodysplastic-syndromes-harboring-a-novel-blm-gene-variant
#9
JOURNAL ARTICLE
Takuma Ohashi, Hiroyoshi Kunimoto, Jun Nukui, Haruka Teshigawara, Satoshi Koyama, Takuya Miyazaki, Maki Hagihara, Kenji Matsumoto, Eriko Koshimizu, Naomi Tsuchida, Haruka Hamanoue, Satoko Miyatake, Akihiro Yachie, Naomichi Matsumoto, Hideaki Nakajima
Bloom syndrome (BS) is an autosomal recessive genetic disorder caused by variants in the BLM gene. BS is characterized by distinct facial features, elongated limbs, and various dermatological complications including photosensitivity, poikiloderma, and telangiectatic erythema. The BLM gene encodes a RecQ helicase critical for genome maintenance, stability, and repair, and a deficiency in functional BLM protein leads to genomic instability and high predisposition to various types of cancers, particularly hematological and gastrointestinal malignancies...
March 15, 2024: International Journal of Hematology
https://read.qxmd.com/read/38488968/mr-contrast-enhanced-mammography-cem-for-follow-up-of-breast-cancer-patients-a-pros-and-cons-debate
#10
JOURNAL ARTICLE
Julia Camps-Herrero, Ruud Pijnappel, Corinne Balleyguier
Women with a personal history of breast cancer (PHBC) are at an increased risk of either a local recurrence or a new primary breast cancer. Thus, surveillance is essential for the detection of recurrent disease at the earliest possible stage, allowing for prompt treatment, and potentially improving overall survival. Nowadays, mammography follow-up is the only surveillance imaging technique recommended by international guidelines. Nevertheless, sensitivity of mammography is lower after breast cancer treatment, particularly during the first 5 years, due to increased density or post-treatment changes...
March 15, 2024: European Radiology
https://read.qxmd.com/read/38484379/-local-treatment-of-ipsilateral-breast-cancer-recurrences-comparison-of-alternative-therapeutic-options
#11
JOURNAL ARTICLE
Viktor Smanykó
We compared the clinical outcomes of second breast conserving therapy (2ndBCT) versus salvage mastectomy (sMT) for the treatment of ipsilateral breast tumour recurrences (IBTR). 195 patients who presented with an IBTR after previous breast conserving treatment were salvaged either with re-excision and perioperative interstitial brachytherapy (n=39) or sMT (n=156). A total dose of 5×4.4Gy was delivered to the tumour bed, on 3 consecutive days. The median follow-up time was 59 and 56 months. During follow-up 4 (10...
March 14, 2024: Magyar Onkologia
https://read.qxmd.com/read/38484175/the-oncological-and-surgical-outcomes-of-immediate-oncoplastic-breast-reconstruction-with-contralateral-breast-adjustment
#12
JOURNAL ARTICLE
Ofir Sahar, Reut Har Zvi, Daphna Barsuk, Yoav Barnea, Or Gelbart Pridan, Keren Hod, Merav Akiva Ben-David
BACKGROUND: Oncoplastic surgery is an expanding approach for managing breast conservation because it offers improved cosmetic outcomes while maintaining oncological safety. OBJECTIVES: This study aimed to assess the oncological and surgical outcomes of patients who underwent oncoplastic procedures at a single institution. METHODS: The study population includes all consecutive breast cancer patients who underwent lumpectomy followed by immediate oncoplastic breast reconstruction with contralateral breast adjustment between 2010 and 2021...
March 14, 2024: Aesthetic Surgery Journal
https://read.qxmd.com/read/38481388/integrating-single-cell-and-spatial-transcriptomes-reveals-col4a1-2-facilitates-the-spatial-organisation-of-stromal-cells-differentiation-in-breast-phyllodes-tumours
#13
JOURNAL ARTICLE
Xia Li, Xuewen Yu, Jiaxin Bi, Xu Jiang, Lu Zhang, Zhixin Li, Mumin Shao
BACKGROUND: Breast phyllodes tumours (PTs) are a unique type of fibroepithelial neoplasms with metastatic potential and recurrence tendency. However, the precise nature of heterogeneity in breast PTs remains poorly understood. This study aimed to elucidate the cell subpopulations composition and spatial structure and investigate diagnostic markers in the pathogenesis of PTs. METHODS: We applied single-cell RNA sequencing and spatial transcriptomes on tumours and adjacent normal tissues for integration analysis...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38480629/tamoxifen-dose-de-escalation-an-effective-strategy-for-reducing-adverse-effects
#14
REVIEW
Sanne M Buijs, Stijn L W Koolen, Ron H J Mathijssen, Agnes Jager
Tamoxifen, a cornerstone in the adjuvant treatment of estrogen receptor-positive breast cancer, significantly reduces breast cancer recurrence and breast cancer mortality; however, its standard adjuvant dose of 20 mg daily presents challenges due to a broad spectrum of adverse effects, contributing to high discontinuation rates. Dose reductions of tamoxifen might be an option to reduce treatment-related toxicity, but large randomized controlled trials investigating the tolerability and, more importantly, efficacy of low-dose tamoxifen in the adjuvant setting are lacking...
March 14, 2024: Drugs
https://read.qxmd.com/read/38477918/adjuvant-ovarian-function-suppression-in-premenopausal-hormone-receptor-positive-breast-cancer
#15
JOURNAL ARTICLE
Robert B Basmadjian, Sasha Lupichuk, Yuan Xu, May Lynn Quan, Winson Y Cheung, Darren R Brenner
IMPORTANCE: Few oncology studies have assessed the effectiveness of adjuvant ovarian function suppression (OFS) in observational settings for premenopausal hormone receptor-positive breast cancer. Target trial emulation is increasingly used for estimating treatment outcomes in observational cohorts. OBJECTIVES: To describe hormone therapy and OFS treatment patterns (aim 1), examine the association between adding OFS to tamoxifen (TAM) or aromatase inhibitor (AI) and survival (aim 2), and examine the association between duration of hormone treatment (TAM or AI) plus OFS (H-OFS) and survival (aim 3)...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38477155/incidence-and-risk-factors-of-breast-cancer-related-lymphedema-in-korea-a-nationwide-retrospective-cohort-study
#16
JOURNAL ARTICLE
Ha Rim Ahn, Hyeong Eun Jeong, Choyun Jeong, Sang Yull Kang, Sung Hoo Jung, Hyun Jo Youn, Jong Seung Kim
BACKGROUND: Breast cancer-related lymphedema (BCRL) is a secondary lymphedema that occurs after breast cancer related treatments. BCRL develops from damage or dysfunction of the normally functioning lymphatic system due to surgery, radiation therapy and rarely due to cancer recurrence. This nationwide, retrospective study was aimed at investigating the incidence and risk factors of BCRL using the database of the Korean National Health Insurance Service (NHIS). METHODS: Patients with newly diagnosed breast cancer who underwent breast surgery from January 1, 2017 to December 31, 2020, were recruited...
March 11, 2024: International Journal of Surgery
https://read.qxmd.com/read/38476641/the-role-of-ki-67-in-hr-her2-breast-cancer-a-real-world-study-of-956-patients
#17
JOURNAL ARTICLE
Qin Ma, Yao-Bang Liu, Tong She, Xin-Lan Liu
OBJECTIVE: This study determined the cut-off value of Ki-67 expression and discussed the interaction between Ki-67 and histological grade, further explored the prognostic role of Ki-67 in hormone receptor-positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) breast cancer;. MATERIALS AND METHODS: We assessed the Ki-67 expression of 956 patients with HR+/HER2 breast cancer diagnosed in the General Hospital of Ningxia Medical University from 2015 to 2019 by immunohistochemistry (IHC), The disease-free survival (DFS) was defined as the time from postoperative to the first local recurrence, distant metastasis or death of the disease...
2024: Breast Cancer: Targets and Therapy
https://read.qxmd.com/read/38476604/granulomatous-mastitis-in-accessory-breast-tissue-a-rare-presentation-and-surgical-management
#18
Abdulwahid M Salih, Lana Rα Pshtiwan, Shaban Latif, Halkawt O Ali, Ari M Abdullah, Hiwa O Baba, Jihad Ibrahim Hama, Shko H Hassan, Marwan N Hassan, Shvan H Mohammed, Mohammed L Ahmed, Fahmi H Kakamad
Granulomatous mastitis (GM) in accessory breast tissue is rare. The present study aimed to report a rare case of GM in accessory breast tissue. A 39-year-old female patient presented with right axillary discomfort and swelling for ~5 days. On clinical examination, a tender, firm lump was detected in the right axillary region. The ultrasound showed diffuse parenchymal heterogeneity and surrounding edema in the right accessory breast associated with reactive axillary lymph nodes. Following unresponsiveness to conservative treatment, a surgical procedure was performed in the form of an excisional biopsy and the lesion was diagnosed as GM...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38476474/tissue-engineering-scaffolds-loaded-with-a-variety-of-plant-extracts-novel-model-in-breast-cancer-therapy
#19
REVIEW
Reyhaneh Azhari Rad, Yasaman Naghdi, Mobina Majidi Jamalabadi, Sima Masoumi, Leila Rezakhani, Morteza Alizadeh
Despite recent improvements in detecting and managing breast cancer (BC), it continues to be a major worldwide health concern that annually affects millions of people. Exploring the anti-BC potentials of natural compounds has received a lot of scientific attention due to their multi-target mode of action and good safety profiles because of these unmet needs. Drugs made from herbs are secure and have a lot fewer negative effects than those made from synthetic materials. Early stage patients benefit from breast-conserving surgery, but the risk of local recurrence remains, necessitating implanted scaffolds...
2024: Breast Cancer: Basic and Clinical Research
https://read.qxmd.com/read/38475902/application-of-fluorocarbon-nanoparticles-of-131-i-fulvestrant-as-a-targeted-radiation-drug-for-endocrine-therapy-on-human-breast-cancer
#20
JOURNAL ARTICLE
Li Zhi, Chen Cheng, Luo Jing, Peng Zhi-Ping, Yang Lu, Tian Yan, Wang Zhi-Gang, Yin Guo-Bing
BACKGROUND: Breast cancer is the most prevalent malignant tumor among women, with hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these receptors, is utilized for advanced metastatic hormone receptor-positive breast cancer. Yet, its inhibitory effect on tumor cells is not strong, and it lacks direct cytotoxicity. Consequently, there's a significant challenge in preventing recurrence and metastasis once cancer cells develop resistance to fulvestrant. METHOD: To address these challenges, we engineered tumor-targeting nanoparticles termed 131 I-fulvestrant-ALA-PFP-FA-NPs...
March 12, 2024: Journal of Nanobiotechnology
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