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https://www.readbyqxmd.com/read/29666294/laryngeal-responses-to-mechanically-assisted-cough-in-progressing-amyotrophic-lateral-sclerosis
#1
Tiina M Andersen, Astrid Sandnes, Ove Fondenes, Roy M Nilsen, Ole-Bjørn Tysnes, John-Helge Heimdal, Hege H Clemm, Thomas Halvorsen, Maria Vollsœter, Ola D Røksund
BACKGROUND: Respiratory complications represent the major cause of death in amyotrophic lateral sclerosis (ALS). Noninvasive respiratory support is the mainstay therapy, but treatment becomes challenging as the disease progresses, possibly due to a malfunctioning larynx, which is the entrance to the airways. We studied laryngeal response patterns to mechanically assisted cough (mechanical insufflation-exsufflation) as ALS progresses. METHODS: This prospective longitudinal study of 13 consecutively included subjects with ALS were followed up during 2011-2016 with repeated tests of lung function, neurological status, and laryngeal responses to mechanical insufflation-exsufflation using video-recorded flexible transnasal fiberoptic laryngoscopy...
April 17, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29664942/dietary-cyanogen-exposure-and-early-child-neurodevelopment-an-observational-study-from-the-democratic-republic-of-congo
#2
Espérance Kashala-Abotnes, Marie-Thérèse Sombo, Daniel L Okitundu, Marcel Kunyu, Guy Bumoko Makila-Mabe, Thorkild Tylleskär, Alla Sikorskii, Jean-Pierre Banea, Dieudonné Mumba Ngoyi, Désiré Tshala-Katumbay, Michael J Boivin
BACKGROUND: Dietary cyanogen exposure from ingesting bitter (toxic) cassava as a main source of food in sub-Saharan Africa is related to neurological impairments in sub-Saharan Africa. We explored possible association with early child neurodevelopmental outcomes. METHODS: We undertook a cross-sectional neurodevelopmental assessment of 12-48 month-old children using the Mullen Scale of Early Learning (MSEL) and the Gensini Gavito Scale (GGS). We used the Hopkins Symptoms Checklist-10 (HSCL-10) and Goldberg Depression Anxiety Scale (GDAS) to screen for symptoms of maternal depression-anxiety...
2018: PloS One
https://www.readbyqxmd.com/read/29662290/extra-intestinal-manifestations-of-non-celiac-gluten-sensitivity-an-expanding-paradigm
#3
REVIEW
Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Annacinzia Amoruso, Enzo Ierardi, Alfredo Di Leo, Michele Barone
Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most cases they are characterized by vague symptoms such as 'foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. NCGS has an immune-related background...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29661209/gastrointestinal-and-urinary-complaints-in-adults-with-hereditary-spastic-paraparesis
#4
Øivind J Kanavin, Krister W Fjermestad
BACKGROUND: Hereditary spastic paraparesis (HSP) is a group of rare genetic disorders affecting the central nervous system. Pure HSP is limited to lower limb spasticity and urinary voiding dysfunction. Complex HSP involves additional neurological features. Beyond the described core symptoms, knowledge about the burden of disease for adults with HSP is limited, particularly regarding gastrointestinal functions, fecal incontinence, and urinary symptoms. METHODS: We conducted a cross-sectional self-report survey with 108 adult HSP patients (Mage  = 57...
April 16, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29660949/concussion-and-the-autonomic-nervous-system-an-introduction-to-the-field-and-the-results-of-a-systematic-review
#5
Jon L Pertab, Tricia L Merkley, Alex J Cramond, Kelly Cramond, Holly Paxton, Trevor Wu
BACKGROUND: Recent evidence suggests that autonomic nervous dysfunction may be one of many potential factors contributing to persisting post-concussion symptoms. OBJECTIVE: This is the first systematic review to explore the impact of concussion on multiple aspects of autonomic nervous system functioning. METHODS: The methods employed are in compliance with the American Academy of Neurology (AAN) and PRISMA standards. Embase, MEDLINE, PsychINFO, and Science Citation Index literature searches were performed using relevant indexing terms for articles published prior to the end of December 2016...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29651832/psychological-wellbeing-in-parents-of-children-with-phenylketonuria-and-association-with-treatment-adherence
#6
Lidia Borghi, Elisabetta Salvatici, Giuseppe Banderali, Enrica Riva, Marcello Giovannini, Elena Vegni
BACKGROUND: Phenylketonuria (PKU) is a rare metabolic disorder that leads to severe neurological abnormalities unless early treated with a strict phenylalanine (Phe)-restricted diet. The parents' involvement in PKU management is crucial and could lead to psychological distress; however, few studies have explored the parents' psychological wellbeing. The study aimed to: 1) evaluate the presence of psychological distress and impaired quality of life among parents of children with PKU, assessing the load of the diagnosis and the load of the treatment management; 2) explore the associations with their children's blood-Phe levels...
April 12, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29643261/primary-results-of-the-multicenter-arise-ii-study-analysis-of-revascularization-in-ischemic-stroke-with-embotrap
#7
Osama O Zaidat, Hormozd Bozorgchami, Marc Ribó, Jeffrey L Saver, Heinrich P Mattle, René Chapot, Ana Paula Narata, Olivier Francois, Ashutosh P Jadhav, Jonathan A Grossberg, Christian H Riedel, Alejandro Tomasello, Wayne M Clark, Hannes Nordmeyer, Eugene Lin, Raul G Nogueira, Albert J Yoo, Tudor G Jovin, Adnan H Siddiqui, Thierry Bernard, Mairsíl Claffey, Tommy Andersson
BACKGROUND AND PURPOSE: EmboTrap is a novel stent retriever designed to achieve rapid and substantial flow restoration in acute ischemic stroke secondary to large-vessel occlusions. Here, we evaluated EmboTrap's safety and efficacy compared with established stent retrievers. METHODS: ARISE II (Analysis of Revascularization in Ischemic Stroke With EmboTrap) was a single-arm, prospective, multicenter study, comparing the EmboTrap device to a composite performance goal criterion derived using a Bayesian meta-analysis from the pivotal SWIFT (Solitaire device) and TREVO 2 (Trevo device) trials...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29628294/the-inpatient-assessment-and-management-of-motor-functional-neurological-disorders-an-interdisciplinary-perspective
#8
Kathleen McKee, Sean Glass, Caitlin Adams, Christopher D Stephen, Franklin King, Kristin Parlman, David L Perez, Nicholas Kontos
BACKGROUND: Motor functional neurologic disorders (FND)-previously termed "hysteria" and later "conversion disorder"-are exceedingly common and frequently encountered in the acute hospital setting. Despite their high prevalence, patients with motor FND can be challenging to diagnose accurately and manage effectively. To date, there is limited guidance on the inpatient approach to the neuropsychiatric evaluation of patients with functional (psychogenic) neurologic symptoms...
January 8, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29627874/meningiomas-skull-base-versus-non-skull-base
#9
Torstein R Meling, Michele Da Broi, David Scheie, Eirik Helseth
To identify differences between skull base meningiomas (SBM) and non-skull base meningiomas (NSBM). All adult patients (18.0-69.9 years) operated for intracranial meningiomas between 1990 and 2010 at our institution were investigated. Al-Mefty's definition was used to dichotomize tumors into SBM and NSBM. Overall, 1148 consecutive patients were identified. Median age at surgery was 54.2 years [18.1-69.9]. Median follow-up was 7.4 years [0.0-20.9]. There were 562 patients (49%) with SBM and 586 (51%) with NSBM...
April 7, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29625339/comparison-of-the-clinical-efficacy-of-craniotomy-and-craniopuncture-therapy-for-the-early-stage-of-moderate-volume-spontaneous-intracerebral-haemorrhage-in-basal-ganglia-using-the-cta-spot-sign-as-an-entry-criterion
#10
Chunyan Ge, Wangmiao Zhao, Hong Guo, Zhaosheng Sun, Wanzeng Zhang, Xiaowei Li, Xuehui Yang, Jinrong Zhang, Dongxin Wang, Yi Xiang, Jianhui Mao, Wenchao Zhang, Hao Guo, Yazhao Zhang, Jianchao Chen
OBJECTIVES: Surgical treatment is widely used for haematoma removal in spontaneous intracerebral haemorrhage (ICH) patients, but there is controversy about the selection of surgical methods. The CT angiography (CTA) spot sign has been proven to be a promising factor predicting haematoma expansion and is recommended as an entry criterion for haemostatic therapy in patients with ICH. This trial was designed to evaluate the clinical efficacy of two surgical methods (haematoma removal by craniotomy and craniopuncture combined with urokinase infusion) for patients in the early stage (≤6h from symptom onset) of spontaneous ICH with a moderate haematoma volume (30 ml - 60 ml)...
April 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29624652/religious-stigmata-a-dermato-psychiatric-approach-and-differential-diagnosis
#11
REVIEW
Elio Kechichian, Elie Khoury, Sami Richa, Roland Tomb
BACKGROUND: Stigma refers to the wounds reproduced on the human body, similar to the ones inflicted on the Christ during his crucifixion, on the palms, soles, and head, as well as the right or the left side of the chest, the lips and, the back. Whether they are genuine or fabricated, stigmata are still considered a medical enigma. OBJECTIVE: To summarize and analyze all available medical data about stigmata, integrating both its dermatological and psychiatric features...
April 6, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29622504/effect-of-surgical-decompression-of-spinal-metastases-in-acute-treatment-predictors-of-neurological-outcome
#12
Christoph Hohenberger, Corinna Schmidt, Julius Höhne, Alexander Brawanski, Florian Zeman, Karl-Michael Schebesch
OBJECTIVE: Space-occupying spinal metastases (SM), commonly diagnosed because of acute neurological deterioration, consequently lead to immediate decompression with tumor removal or debulking. In this study, we analyzed a series of patients with surgically treated spinal metastases and explicitly sought to determine individual predictors of functional outcome. PATIENTS AND METHODS: 94 patients (26 women, 68 men; mean age 64.0 years) with spinal metastases, who had been surgically treated at our department, were included retrospectively...
April 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29621974/characteristics-of-a-newly-diagnosed-polish-cohort-of-patients-with-neurological-manifestations-of-wilson-disease-evaluated-with-the-unified-wilson-s-disease-rating-scale
#13
Anna Członkowska, Tomasz Litwin, Karolina Dzieżyc, Michal Karliński, Johan Bring, Carl Bjartmar
BACKGROUND: Wilson disease is a rare genetic disorder in which impaired copper excretion results in toxic copper levels and tissue damage. Manifestations are primarily hepatic and/or neuropsychiatric, with a variety of neurological phenotypes. The aim of this study was to characterize neurological signs of Wilson disease in newly diagnosed patients and to determine whether they correlated with disability, liver function, and copper metabolism. METHODS: Fifty-three treatment-naïve patients recently diagnosed with Wilson disease who exhibited neurological symptoms were included...
April 5, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29619928/studies-of-upper-limb-pain-in-occupational-medicine-in-general-practice-and-among-computer-operators
#14
Jørgen Riis Jepsen
Diagnostic consensus criteria cannot be applied in a major proportion of patients with upper limb complaints, many of which are regarded as "non-specific". The three empirical studies in this thesis aimed to address this diagnostic challenge by incorporating representative neurological qualities in the physical examination.
Patterns of muscle weakness, sensory abnormalities and nerve trunk allodynia based on the nerves' topography and their motor and cutaneous innervation were defined to reflect peripheral nerve afflictions and their locations...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619565/quantitative-assessment-of-finger-tapping-characteristics-in-mild-cognitive-impairment-alzheimer-s-disease-and-parkinson-s-disease
#15
David R Roalf, Petra Rupert, Dawn Mechanic-Hamilton, Laura Brennan, John E Duda, Daniel Weintraub, John Q Trojanowski, David Wolk, Paul J Moberg
BACKGROUND: Fine motor impairments are common in neurodegenerative disorders, yet standardized, quantitative measurements of motor abilities are uncommonly used in neurological practice. Thus, understanding and comparing fine motor abilities across disorders have been limited. OBJECTIVES: The current study compared differences in finger tapping, inter-tap interval, and variability in Alzheimer's disease (AD), Parkinson's disease (PD), mild cognitive impairment (MCI), and healthy older adults (HOA)...
April 4, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29618054/influence-of-residual-disease-following-surgical-resection-in-newly-diagnosed-glioblastoma-on-clinical-neurocognitive-and-patient-reported-outcomes
#16
William A Hall, Stephanie L Pugh, Jeffrey S Wefel, Terri S Armstrong, Mark R Gilbert, David G Brachman, Maria Werner-Wasik, Merideth M Wendland, Paul D Brown, Samuel T Chao, Kevin S Roof, H Ian Robins, Minesh P Mehta, Walter J Curran, Benjamin Movsas
BACKGROUND: The influence of subtotal resection (STR) on neurocognitive function (NCF), quality of life, and symptom burden in glioblastoma is unknown. If bevacizumab preferentially benefits patients with STR is unknown. OBJECTIVE: To examine these uncertainties. METHODS: NCF and patient reported outcomes (PRO) were prospectively collected in NRG Oncology RTOG 0525 and 0825. Changes in NCF and PRO measures from baseline to prespecified times were examined by Wilcoxon test, and mixed effects longitudinal modeling, to assess differences between patients who received STR vs gross-total resection...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29616233/normal-brain-imaging-accompanies-neuroimmunologically-justified-autoimmune-encephalomyelitis
#17
Daiki Takewaki, Youwei Lin, Wakiro Sato, Hirohiko Ono, Masakazu Nakamura, Manabu Araki, Tomoko Okamoto, Yuji Takahashi, Yukio Kimura, Miho Ota, Noriko Sato, Takashi Yamamura
Objective: To examine cases with a clinical course, signs, and symptoms mimicking MS, but without abnormalities on conventional MRI. Methods: Among 550 people with a tentative diagnosis of MS or neuromyelitis optica spectrum disorder (NMOSD), we selected patients, who met the 2010 McDonald diagnosis criteria for MS, but did not show abnormal findings on conventional brain and spinal cord MRI. After evaluating their clinical data, we analyzed fractional anisotropy (FA) values in the brain white matter on diffusion tensor MRIs and the frequencies of B-cell subsets in the peripheral blood in the corresponding cases as compared to healthy controls...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29615017/clinical-and-radiographic-outcome-of-dynamic-cervical-implant-dci-arthroplasty-for-degenerative-cervical-disc-disease-a-minimal-five-year-follow-up
#18
Lin-Nan Wang, Bo-Wen Hu, Lei Wang, Yue-Ming Song, Xi Yang, Li-Min Liu, Hao Liu
BACKGROUND: To evaluate the mid- to long-term clinical and radiographic outcomes of anterior cervical discectomy and dynamic cervical implant (DCI) arthroplasty for degenerative cervical disc disease. METHODS: From April 2010 to October 2010, 38 patients with single- or double-level cervical disc herniation underwent anterior cervical discectomy and DCI arthroplasty. The clinical results and radiographic outcomes of these 38 patients (42 levels) were retrospectively evaluated...
April 4, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29614641/neuropsychiatric-symptoms-and-the-diagnostic-stability-of-mild-cognitive-impairment
#19
Michael A Sugarman, Michael L Alosco, Yorghos Tripodis, Eric G Steinberg, Robert A Stern
BACKGROUND: Mild cognitive impairment (MCI) is an intermediate diagnosis between normal cognition (NC) and dementia, including Alzheimer's disease (AD) dementia. However, MCI is heterogeneous; many individuals subsequently revert to NC while others remain stable at MCI for several years. Identifying factors associated with this diagnostic instability could assist in defining clinical populations and determining cognitive prognoses. OBJECTIVE: The current study examined whether neuropsychiatric symptoms could partially account for the temporal instability in cognitive diagnoses...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29610014/gain-of-function-mutation-and-inflammasome-driven-diseases-in-human-and-mouse-models
#20
REVIEW
Mario D Cordero, Elísabet Alcocer-Gómez, Bernhard Ryffel
Activation of the NLRP3 inflammasome, a multiprotein complex, leading to caspase activation with production of proinflammatory IL-1β represents a major pathway of inflammation. Recent, studies in mice and human patients uncovered several gain-of- function (GOF) mutations in inflammasome sensor proteins that allow inflammasome assembly in the absence of cognate ligands to trigger autoinflammatory syndromes. Cryopyrin-associated periodic syndromes (CAPS) are rare autoinflammatory diseases, comprising a broad disease spectrum with varying severity...
March 30, 2018: Journal of Autoimmunity
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