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Functional neurologic symptom

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https://www.readbyqxmd.com/read/29908963/nonfunctional-mutant-wrn-protein-leads-to-neurological-deficits-neuronal-stress-microglial-alteration-and-immune-imbalance-in-a-mouse-model-of-werner-syndrome
#1
Chin Wai Hui, Marie-Kim St-Pierre, Jérôme Detuncq, Lucie Aumailley, Marie-Julie Dubois, Vanessa Couture, Daniel Skuk, André Marette, Jacques P Tremblay, Michel Lebel, Marie-Ève Tremblay
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter lifespan. Yet, little is known about the impact of WRN mutations on the central nervous system in both humans and mouse models of WS. In the current study, we have performed a longitudinal behavioral assessment on mice bearing a Wrn helicase deletion. Behavioral tests demonstrated a loss of motor activity and coordination, reduction in perception, increase in repetitive behavior, and deficits in both spatial and social novelty memories in Wrn mutant mice compared to age-matched wild type mice...
June 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29908719/inter-capsular-resection-of-cervical-vagus-nerve-schwannoma
#2
Masafumi Kuroiwa, Takehiro Yako, Tetsuya Goto, Kayoko Higuchi, Kazuo Kitazawa, Tetsuyoshi Horiuchi, Shigeaki Kobayashi
Cervical vagus nerve schwannoma is rare and its surgical procedure is controversial. The tumor is in general benign and slowly growing without causing symptoms, and therefore it should be advised to remove the tumor while preserving neural function. We operated on two patients with cervical vagus nerve schwannoma with the inter-capsular resection technique proposed by Hashimoto et al. without causing neurological deficits. It is the first time that the plane between the tumor-complex capsule layer (epineurium and perineurium) and true tumor capsule layer was histopathologically proved in this paper...
June 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29907475/radiotherapy-for-langerhans-cell-histiocytosis-with-paraplegia-a-rare-oncologic-emergency-case-report-in-infancy-and-literature-review
#3
Kentaro Nakashima, Yuhki Koga, Yasunari Sakai, Hidetoshi Takada, Katsumi Harimaya, Saiji Ohga, Tomoaki Taguchi, Yoshinao Oda, Hiroshi Honda, Shouichi Ohga
BACKGROUND: Langerhans cell histiocytosis (LCH) is a clonal disease with focal or disseminated lesions that may compress the surrounding tissues, including the spinal cord. Because few reports have described the spinal symptoms as the first manifestation of pediatric LCH, the long-term neurological outcomes remain unclear. CASE REPORT AND LITERATURE REVIEW: We report a 21-month-old boy who presented with sudden-onset paraplegia. Imaging analyses revealed that osteolytic lesions and epidural tumors compressing the spinal cord at the T7-9 vertebrae...
June 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29904888/olfactory-dysfunction-in-neurodegenerative-diseases
#4
REVIEW
Concepció Marin, Dolores Vilas, Cristóbal Langdon, Isam Alobid, Mauricio López-Chacón, Antje Haehner, Thomas Hummel, Joaquim Mullol
PURPOSE OF REVIEW: The sense of smell is today one of the focuses of interest in aging and neurodegenerative disease research. In several neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, the olfactory dysfunction is one of the initial symptoms appearing years before motor symptoms and cognitive decline, being considered a clinical marker of these diseases' early stages and a marker of disease progression and cognitive decline. Overall and under the umbrella of precision medicine, attention to olfactory function may help to improve chances of success for neuroprotective and disease-modifying therapeutic strategies...
June 15, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29904454/a-rare-case-of-native-mitral-valve-bacillus-cereus-endocarditis-culminating-into-a-cerebrovascular-infarction
#5
Bibai Ren, Glenmore Lasam
We report a case of a 56-year-old man who presented initially with a sudden onset of right-sided facial droop and weakness, aphasia, and confusion with no associated fever, chills, syncope, fatigue, weight loss, night sweats, nausea, vomiting, diarrhea, odontalgia, palpitations, cough, or dyspnea. Code stroke was called and the patient received tissue plasminogen activator (tPA) with subsequent resolution of his symptoms. Cranial magnetic resonance imaging showed left frontal punctate cortical restricted diffusion consistent with subacute to acute infarction...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29896560/single-dose-lidocaine-spinal-anesthesia-in-hip-and-knee-arthroplasty
#6
Nicholas B Frisch, Brian Darrith, Dane C Hansen, Adrienne Wells, Sheila Sanders, Richard A Berger
Background: With the increasing interest in fast recovery and outpatient joint arthroplasty, short-acting local anesthetic agents and minimal narcotic use are preferred. Lidocaine is a fast-onset, short-duration local anesthetic that has been used for many years in spinal anesthesia. However, lidocaine spinal anesthesia has been reported to have a risk of transient neurologic symptoms (TNSs). The purpose of this study is to determine the safety and efficacy of single-dose lidocaine spinal anesthesia in the setting of outpatient joint arthroplasty...
June 2018: Arthroplasty Today
https://www.readbyqxmd.com/read/29894456/objective-assessment-of-lingual-nerve-microsurgical-reconstruction
#7
Federico Biglioli, Alessandro Lozza, Giacomo Colletti, Fabiana Allevi
Lingual nerve (LN) injury is one of the most serious consequences of oral surgery. Prompt microsurgical reconstruction of the nerve can alleviate most of those symptoms leading to satisfactory functional recovery.Thirty-five patients with partial to complete LN injury underwent surgery in the period between January 2006 and May 2015. All patients underwent a preoperative clinical and neurological evaluation with the assessment of lingual tactile and pain sensory thresholds and masseteric inhibitory reflex.All patients underwent explorative surgery and direct microneurorrhaphy of distal and proximal stumps in case of complete lesion, while the removal of traumatic neuroma and the following microneurorrhaphy of distal and proximal stumps of the injured nerve was performed in case of incomplete lesion...
June 11, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29889077/cancer-from-wild-type-to-mutant-huntingtin
#8
Morgane Sonia Thion, Sandrine Humbert
Huntingtin (HTT) is a scaffold protein mostly known because it gives rise to the severe and incurable inherited neurological disorder Huntington's disease (HD) when mutated. The Huntingtin gene (HTT) carries a polymorphic trinucleotide expansion of CAGs in exon 1 that ranges from 9 to 35 in the non-HD affected population. However, if it exceeds 35 CAG repeats, the altered protein is referred to as mutant HTT and leads to the development of HD. Given the wide spectrum of severe symptoms developed by HD individuals, wild-type and mutant HTT have been mostly studied in the context of this disorder...
June 4, 2018: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/29879784/surgical-outcomes-of-pediatric-patients-with-asymptomatic-tethered-cord-syndrome
#9
Toshitaka Seki, Kazutoshi Hida, Shunsuke Yano, Kiyohiro Houkin
STUDY DESIGN: A retrospective cohort study. PURPOSE: To examine the validity of prophylactic surgery for children with tethered cord syndrome (TCS). OVERVIEW OF LITERATURE: Prophylactic surgery for pediatric patients with TCS remains controversial. METHODS: We retrospectively analyzed the surgical outcomes of 14 children (nine boys and five girls) with asymptomatic TCS who were surgically treated at Hokkaido University Hospital between 1989 and 2015...
June 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29877965/physiology-of-transcranial-direct-current-stimulation
#10
Charlotte J Stagg, Andrea Antal, Michael A Nitsche
Direct current stimulation is a neuromodulatory noninvasive brain stimulation tool, which was first introduced in animal and human experiments in the 1950s, and added to the standard arsenal of methods to alter brain physiology as well as psychological, motor, and behavioral processes and clinical symptoms in neurological and psychiatric diseases about 20 years ago. In contrast to other noninvasive brain stimulation tools, such as transcranial magnetic stimulation, it does not directly induce cerebral activity, but rather alters spontaneous brain activity and excitability by subthreshold modulation of neuronal membranes...
June 5, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29876911/-new-insights-in-inborn-errors-of-metabolism-are-leading-to-new-paradigms-in-child-neurology
#11
A Garcia-Cazorla, J M Saudubray
In the last recent years, the -omics era has already transformed child neurology. Next generation sequencing (NGS) has identified many novel disease causing genes and phenotypes. While genetics is of great importance as a diagnostic tool, it is less helpful when it comes to a comprehensive understanding of mechanisms of brain dysfunction. Child neurologists are at high risk of being lost in genomics if they do not face the necessity of a new approach in their clinical practice. The large amount of data provided by NGS is just one more element in a complex puzzle...
June 5, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29876262/-motoring-in-idle-the-default-mode-and-somatomotor-networks-are-overactive-in-children-and-adolescents-with-functional-neurological-symptoms
#12
Kasia Kozlowska, Chris J Spooner, Donna M Palmer, Anthony Harris, Mayuresh S Korgaonkar, Stephen Scher, Leanne M Williams
Objective: Children and adolescents with functional neurological symptom disorder (FND) present with diverse neurological symptoms not explained by a disease process. Functional neurological symptoms have been conceptualized as somatoform dissociation, a disruption of the brain's intrinsic organization and reversion to a more primitive level of function. We used EEG to investigate neural function and functional brain organization in children/adolescents with FND. Method: EEG was recorded in the resting eyes-open condition in 57 patients (aged 8...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29876020/thyroid-function-in-the-etiology-of-fatigue-in-breast-cancer
#13
Nagi B Kumar, Angelina Fink, Silvina Levis, Ping Xu, Roy Tamura, Jeffrey Krischer
Background: Cancer related fatigue (CRF), reported in about 90% of breast cancer patients receiving chemotherapy, and has a profound impact on physical function, psychological distress and quality of life. Although several etiological factors such as anemia, depression, chronic inflammation, neurological pathology and alterations in metabolism have been proposed, the mechanisms of CRF are largely unknown. Methods: We conducted a pilot, prospective, case-control study to estimate the magnitude of change in thyroid function in breast cancer patients from baseline to 24 months, compared to cancer-free, age-matched controls...
May 22, 2018: Oncotarget
https://www.readbyqxmd.com/read/29872383/from-the-bottom-up-chemotherapy-and-gut-brain-axis-dysregulation
#14
REVIEW
Juliana E Bajic, Ian N Johnston, Gordon S Howarth, Mark R Hutchinson
The central nervous system and gastrointestinal tract form the primary targets of chemotherapy-induced toxicities. Symptoms associated with damage to these regions have been clinically termed chemotherapy-induced cognitive impairment and mucositis. Whilst extensive literature outlines the complex etiology of each pathology, to date neither chemotherapy-induced side-effect has considered the potential impact of one on the pathogenesis of the other disorder. This is surprising considering the close bidirectional relationship shared between each organ; the gut-brain axis...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29868890/current-concepts-in-diagnosis-and-treatment-of-functional-neurological-disorders
#15
Alberto J Espay, Selma Aybek, Alan Carson, Mark J Edwards, Laura H Goldstein, Mark Hallett, Kathrin LaFaver, W Curt LaFrance, Anthony E Lang, Tim Nicholson, Glenn Nielsen, Markus Reuber, Valerie Voon, Jon Stone, Francesca Morgante
Importance: Functional neurological disorders (FND) are common sources of disability in medicine. Patients have often been misdiagnosed, correctly diagnosed after lengthy delays, and/or subjected to poorly delivered diagnoses that prevent diagnostic understanding and lead to inappropriate treatments, iatrogenic harm, unnecessary and costly evaluations, and poor outcomes. Observations: Functional Neurological Symptom Disorder/Conversion Disorder was adopted by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, replacing the term psychogenic with functional and removing the criterion of psychological stress as a prerequisite for FND...
June 4, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29865933/complex-regional-pain-syndrome-type-1-in-the-medico-legal-setting-high-rates-of-somatoform-disorders-opiate-use-and-diagnostic-uncertainty
#16
Christopher Bass, Gregory Yates
Objective The aim of this study was to review demographic and clinical characteristics of patients with complex regional pain syndrome type 1 (CRPS) seen in a UK medico-legal setting - particularly the relationship between CRPS and somatoform disorders. Methods Fifty consecutive cases of CRPS (interviewed 2005-2016) undergoing psychiatric assessment were reviewed. A systematic assessment of mental states was conducted via interview and examination of medical/psychiatric records. Thirty patients also completed the Brief Illness Perception Questionnaire (BIPQ)...
January 1, 2018: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/29864558/cervical-gibbectomy-for-rigid-rounded-kyphosis-in-a-pediatric-patient-surgical-planning-with-technical-note
#17
Kunal C Shah, Akshay Gadia, Uday Pawar, Abhay Nene
OBJECTIVES: Cervical kyphosis surgery poses significant challenge to the spine surgeons. Etiologies of cervical kyphosis are many, each having its own outcome and treatment challenges. Irrespective of the etiology, the treating physician should consider all options fully to improve function and prevent neurological worsening. We outline management principles and decision-making in case of rigid rounded kyphosis of cervical spine and highlight the technique of the internal gibbectomy procedure, which is never reported in cervical spine METHODS: We report a case of Ewing's sarcoma of cervical spine that presented with progressive myelopathy symptoms...
June 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29863688/-the-prognosis-for-post-stroke-aphasia
#18
V V Alferova, V M Shklovskij, E G Ivanova, G V Ivanov, L A Mayorova, A G Petrushevsky, S V Kuptsova, A B Guekht
AIM: To determine risk factors and factors of favorable prognosis for regression of post-stroke aphasia in the early recovery period of ischemic stroke (IS). MATERIAL AND METHODS: A cohort study was undertaken with 40 patients with different clinical forms of aphasia. The duration of study was 3-4 months of the disease. The regression of speech and non-speech cognitive impairment was assessed by the Method of a 10-point evaluation of higher mental functions. The method involves a comprehensive assessment of all mental functions with more than 90 subtests at the beginning and at the end of rehabilitation course and the calculation of the difference in the scoring of each mental function as a measure of treatment efficacy...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29861534/understanding-activity-participation-among-individuals-with-wolfram-syndrome
#19
Emily Bumpus, Tamara Hershey, Tasha Doty, Samantha Ranck, Meredith Gronski, Fumihko Urano, Erin R Foster
Introduction: Wolfram Syndrome (WFS) is a rare genetic disease associated with a variety of progressive metabolic and neurologic impairments. Previous research has focused on WFS-related impairments and biomarkers for disease progression; however, information about how WFS impacts participation in daily activities is lacking. Methods: WFS (n=45; 20 children, 25 adults) participants completed an online questionnaire about activity participation. Thirty-six non-WFS comparison participants (11 children; 25 adults) completed a portion of the questionnaire...
June 2018: British Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29861191/a-large-case-series-of-successful-treatment-of-patients-exposed-to-mold-and-mycotoxin
#20
William J Rea
PURPOSE: The goal of this study was to present the results of treatment of 100 chemically sensitive and chronically mold-exposed patients, who continued to be disabled even after decontamination of their houses or work places or they were physically removed from their sources of mold. METHODS: Molds were identified, serum anti-mold immunoglobulin G antibodies were measured, patients were skin-tested, immunologic abnormalities were recorded, and objective neurologic tests were performed in a subset of patients...
May 31, 2018: Clinical Therapeutics
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