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Functional neurologic symptom

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https://www.readbyqxmd.com/read/29218227/lessons-learnt-from-a-case-of-missed-central-hypothyroidism
#1
Tessa Glyn, Beverley Harris, Kate Allen
We present the case of a 57-year-old lady who had a delayed diagnosis of central hypothyroidism on a background of Grave's thyrotoxicosis and a partial thyroidectomy. During the twenty years following her partial thyroidectomy, the patient developed a constellation of symptoms and new diagnoses, which were investigated by numerous specialists from various fields, namely rheumatology, renal and respiratory. She developed significantly impaired renal function and raised creatine kinase (CK). She was also referred to a tertiary neurology service for investigation of myositis, which resulted in inconclusive muscle biopsies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29216914/rasch-analysis-of-the-participation-scale-p-scale-usefulness-of-the-p-scale-to-a-rehabilitation-services-network
#2
Mariana Angélica Peixoto Souza, Wendy Jane Coster, Marisa Cotta Mancini, Fabiana Caetano Martins Silva Dutra, Jessica Kramer, Rosana Ferreira Sampaio
BACKGROUND: A person's participation is acknowledged as an important outcome of the rehabilitation process. The Participation Scale (P-Scale) is an instrument that was designed to assess the participation of individuals with a health condition or disability. The scale was developed in an effort to better describe the participation of people living in middle-income and low-income countries. The aim of this study was to use Rasch analysis to examine whether the Participation Scale is suitable to assess the perceived ability to take part in participation situations by patients with diverse levels of function...
December 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29216834/inventory-of-real-world-data-sources-in-parkinson-s-disease
#3
Audrey Tanguy, Linus Jönsson, Lianna Ishihara
BACKGROUND: Real world data have an important role to play in the evaluation of epidemiology and burden of disease; and in assisting health-care decision-makers, especially related to coverage and payment decisions. However, there is currently no overview of the existing longitudinal real world data sources in Parkinson's disease (PD) in the USA. Such an assessment can be very helpful, to support a future effort to harmonize real world data collection and use the available resources in an optimal way...
December 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29216828/factors-necessary-for-independent-walking-in-patients-with-thalamic-hemorrhage
#4
Shigenori Hiraoka, Shinichiro Maeshima, Hideto Okazaki, Hirokazu Hori, Shinichiro Tanaka, Sayaka Okamoto, Reisuke Funahashi, Kei Yagihashi, Ikuko Fuse, Naoki Asano, Shigeru Sonoda
BACKGROUND: Thalamic hemorrhages cause motor paralysis, sensory impairment, and cognitive dysfunctions, all of which may significantly affect walking independence. We examined the factors related to independent walking in patients with thalamic hemorrhage who were admitted to a rehabilitation hospital. METHODS: We evaluated 128 patients with thalamic hemorrhage (75 men and 53 women; age range, 40-93 years) who were admitted to our rehabilitation hospital. The mean duration from symptom onset to rehabilitation hospital admission was 27...
December 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29214049/latent-autoimmune-diabetes-of-adulthood-case-report
#5
Cristen P Page, Brian Fitzgerald, Emily M Hawes
Background: Primary care clinicians will see a higher incidence of type 2 diabetes in adult patients, and the diagnosis and management of an initial presentation of type 1 diabetes can pose challenges to clinicians who see it less frequently. Symptoms of hyperglycemia and risk of ketoacidosis may be missed. Further, endocrine autoimmune disease can run together in patients and families. Case presentation: A 49-year-old Caucasian female with history of pituitary adenoma and Graves' disease with history of thyroid ablation presented in the outpatient setting due to hand tingling of her right middle finger that was worse in the mornings and improved throughout the day...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29213529/therapeutic-effect-of-transcranial-direct-current-stimulation-on-neuropsychological-symptoms-of-an-elderly-patient-a-case-report
#6
Aline Iannone, Joaquim Brasil-Neto, Antonio Pedro Mello Cruz, Corina Satler, Nasser Allam
Although growing evidence points to the potential therapeutic effects of transcranial Direct Current Stimulation (tDCS), there is still no consensus on the most appropriate protocol to be used in specific neurological and neuropsychological symptoms. This case report evaluated the neuromodulatory therapeutic effects of two 15-day courses of tDCS on an elderly female patient, aged 78 years with mild neurocognitive disorder, chronic pain and depression-related symptoms. Results indicated an overall significant improvement of cognitive and executive functions, as well as reduction in both depression and chronic pain symptoms...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29212396/dysautonomia-in-the-pathogenesis-of-migraine
#7
Parisa Gazerani, Brian Edwin Cairns
Migraine is a common complex neurological disorder involving multiple brain areas that regulate autonomic, affective, cognitive, and sensory functions. This review explores autonomic nervous system (ANS) dysfunction in migraine headache sufferers. Areas covered: Reference material for this review was obtained through PubMed searches. Migraine attacks can present with up to 4 phases (premonitory, aura, headache, postdrome) each with distinguishable signs and symptoms. Altered ANS tone can be found from the premonitory through the postdrome phases...
December 7, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29209156/machine-learning-classification-combining-multiple-features-of-a-hyper-network-of-fmri-data-in-alzheimer-s-disease
#8
Hao Guo, Fan Zhang, Junjie Chen, Yong Xu, Jie Xiang
Exploring functional interactions among various brain regions is helpful for understanding the pathological underpinnings of neurological disorders. Brain networks provide an important representation of those functional interactions, and thus are widely applied in the diagnosis and classification of neurodegenerative diseases. Many mental disorders involve a sharp decline in cognitive ability as a major symptom, which can be caused by abnormal connectivity patterns among several brain regions. However, conventional functional connectivity networks are usually constructed based on pairwise correlations among different brain regions...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29208729/persistent-postural-perceptual-dizziness-pppd-a-common-characteristic-and-treatable-cause-of-chronic-dizziness
#9
REVIEW
Stoyan Popkirov, Jeffrey P Staab, Jon Stone
Persistent postural-perceptual dizziness (PPPD) is a newly defined diagnostic syndrome that unifies key features of chronic subjective dizziness, phobic postural vertigo and related disorders. It describes a common chronic dysfunction of the vestibular system and brain that produces persistent dizziness, non-spinning vertigo and/or unsteadiness. The disorder constitutes a long-term maladaptation to a neuro-otological, medical or psychological event that triggered vestibular symptoms, and is usefully considered within the spectrum of other functional neurological disorders...
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29208534/loss-of-cdkl5-disrupts-respiratory-function-in-mice
#10
Kun-Ze Lee, Wenlin Liao
Cyclin-dependent kinase-like 5 (CDKL5) is an X-linked gene encoding a serine-threonine kinase that is highly expressed in the central nervous system. Mutations in CDKL5 cause neurological and psychiatric symptoms, including early-onset seizures, motor dysfunction, autistic features and sleep breathing abnormalities in patients. It remains to be addressed whether loss of CDKL5 causes respiratory dysfunction in mice. Here, we examined the respiratory pattern of male Cdkl5-/y mice at 1-3 months of age during resting breathing and respiratory challenge (i...
December 2, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29205262/perceptions-on-the-value-of-bodily-functions-in-multiple-sclerosis
#11
C Heesen, R Haase, S Melzig, J Poettgen, M Berghoff, P Friedemann, U Zettl, M Marziniak, K Angstwurm, R Kern, T Ziemssen, J P Stellmann
BACKGROUND: In neurological diseases presenting with a plethora of symptoms, the value of bodily functions for a given patient might be a guide for clinical management. Multiple sclerosis (MS) is paradigmatic in this respect, and little is known about the value of different bodily functions of patients and their physicians' perceptions. METHODS: In a multicenter study, 171 patients with relapsing-remitting multiple sclerosis (RRMS), 61% with a clinically active disease within the last 2 years were followed over up to 3 years and yearly patients and their study physician rated on the perceived value of 13 bodily functions via a priority list...
December 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29204279/sellar-plasmacytoma-presenting-with-symptoms-of-anterior-pituitary-dysfunction
#12
Ana G Ferreira, Tiago N Silva, Henrique V Luiz, Filipa D Campos, Maria C Cordeiro, Jorge R Portugal
Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. We describe a case associated with extensive anterior pituitary involvement, which is a rare form of presentation. A 68-year-old man was referred to our Endocrinology outpatient clinic due to gynecomastia, reduced libido and sexual impotence...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29204183/evaluation-of-outcomes-for-psychosis-and-epilepsy-treatment-delivered-by-primary-health-care-workers-in-nepal-a-cohort-study
#13
M J D Jordans, L Aldridge, N P Luitel, F Baingana, B A Kohrt
Background: Most evaluations of task-shifting have focused on common mental disorders. Much less work has been done on severe mental neurological and substance use (MNS) disorders, such as chronic psychosis and epilepsy. Given the high burden associated with severe MNS and the lack of mental health professionals in low and middle income countries, evaluations on the impact of task-shifting for these disorders are important. Methods: In a rural district of Nepal, a community mental health program, based on World Health Organization's Mental Health Gap Action Programme guidelines, was evaluated using a cohort study design...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29201045/functional-bowel-disorders-are-associated-with-a-central-immune-activation
#14
Per G Farup, Thor Ueland, Knut Rudi, Stian Lydersen, Knut Hestad
Background: Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders. Methods: The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS)...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29198853/effects-of-exercise-on-cancer-patients-suffering-chemotherapy-induced-peripheral-neuropathy-undergoing-treatment-a-systematic-review
#15
REVIEW
Federica Duregon, Barbara Vendramin, Valentina Bullo, Stefano Gobbo, Cugusi Lucia, Andrea Di Blasio, Daniel Neunhaeuserer, Marco Zaccaria, Marco Bergamin, Andrea Ermolao
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurological and clinically relevant side effect of many commonly used chemotherapeutic agents. Moreover, little effort has been done to investigate the potentially beneficial effects of specific exercises to counteract the CIPN symptoms. OBJECTIVE: This document aims to summarize and analyze systematically the current body of evidence about the effects of specific exercise protocols on CIPN symptoms, balance control, physical function and quality of life in patients with CIPN...
November 7, 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198278/brain-based-biomarkers-for-the-treatment-of-depression-evolution-of-an-idea
#16
Allison C Waters, Helen S Mayberg
An ambition of depression biomarker research is to augment psychometric and cognitive assessment of clinically relevant phenomena with neural measures. Although such applications have been slow to arrive, we observe a steady evolution of the idea and anticipate emerging technologies with some optimism. To highlight critical themes and innovations in depression biomarker research, we take as our point of reference a specific research narrative. We begin with an early model of frontal-limbic dysfunction, which represents a conceptual shift from localized pathology to understanding symptoms as an emergent property of distributed networks...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29194534/why-not-try-harder-computational-approach-to-motivation-deficits-in-neuro-psychiatric-diseases
#17
Mathias Pessiglione, Fabien Vinckier, Sébastien Bouret, Jean Daunizeau, Raphaël Le Bouc
Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric diseases. Even when they are not the core symptom, they reduce quality of life, compromise functional outcome and increase the burden for caregivers. They are currently assessed with clinical scales that do not give any mechanistic insight susceptible to guide therapeutic intervention. Here, we present another approach that consists of phenotyping the behaviour of patients in motivation tests, using computational models...
November 29, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29192875/circumferential-dural-resection-technique-and-reconstruction-for-the-removal-of-giant-calcified-transdural-herniated-thoracic-discs
#18
Corey T Walker, M Yashar S Kalani, Mark E Oppenlander, Jakub Godzik, Nikolay L Martirosyan, Robert J Standerfer, Nicholas Theodore
OBJECTIVE The authors report a novel paradigm for resection of the disc or dural complex to treat giant calcified transdural herniated thoracic discs, and they describe a technique for the repair of dural defects. These herniated thoracic discs are uncommon, complicated lesions that often require a multidisciplinary team for effective treatment. The intradural component must be removed to effectively decompress the spinal cord. The opening of the friable dura mater, which frequently adheres to the extradural component of the disc, can result in large defects and difficult-to-manage CSF leaks...
December 1, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29186725/-screening-of-executive-functions-in-patients-with-parkinson-s-disease-using-the-new-rapid-test-pal-5
#19
Jannik Florian Scheffels, Jasmin Elaine Engels, Elke Kalbe, Josef Kessler
Parkinson's disease (PD) is the second most prevalent chronic neurodegenerative disorder worldwide, following Alzheimer's disease. Along with the characteristic motor symptoms of the disorder, especially bradykinesia, cognitive deficits can often be found prior to the onset of the disorder. These mainly concern executive functioning. To detect cognitive deficits at an early stage, initial screening procedures are recommended. The new cognitive rapid test Paarassoziationslernen-5 ("PAL-5") has been developed to detect the most prevalent cognitive symptoms - namely executive impairments - of PD patients...
November 29, 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29185540/functional-movement-disorders-five-new-things
#20
Tamara Pringsheim, Mark Edwards
Purpose of review: Functional movement disorders (FMD) are commonly seen in neurologic practice, but are associated with poor outcomes. Recent years have seen a resurgence of interest in this area, with new developments in pathophysiologic understanding and therapeutic management. Recent findings: Individuals with FMD are a psychologically heterogeneous group, with many individuals having no detectable psychopathology on symptom screening measures, and possibly significant etiologically relevant life events only revealed through in-depth interviews...
April 2017: Neurology. Clinical Practice
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