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https://www.readbyqxmd.com/read/29474316/autoantibodies-against-n-methyl-d-aspartate-receptor-1-in-health-and-disease
#1
Hannelore Ehrenreich
PURPOSE OF REVIEW: Humoral autoimmunity has gained highest interest in neurology and psychiatry. Despite numerous recent articles on this hot topic, however, the biological significance of natural autoantibodies (AB) and the normal autoimmune repertoire of mammals remained quite obscure. AB may contribute to disorder-relevant phenotypes and are even believed to induce diseases themselves, but the circumstances under which AB become pathogenic are not fully understood. This review will focus on the highly frequent AB against the N-methyl-d-aspartate receptor 1 (NMDAR1-AB) as an illustrating example and provide a critical overview of current work (please note that the new nomenclature, GluN1, is disregarded here for consistency with the AB literature)...
February 22, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29473781/prediction-of-depression-and-anxiety-via-patient-assessed-tremor-severity-not-physician-reported-motor-symptom-severity-in-patients-with-parkinson-s-disease-or-essential-tremor-who-have-undergone-deep-brain-stimulation
#2
Rebecca L Achey, Erin Yamamoto, Daniel Sexton, Christine Hammer, Bryan S Lee, Robert S Butler, Nicolas R Thompson, Sean J Nagel, Andre G Machado, Darlene A Lobel
OBJECTIVE Deep brain stimulation (DBS) is an effective therapy for movement disorders such as idiopathic Parkinson's disease (PD) and essential tremor (ET). However, some patients who demonstrate benefit on objective motor function tests do not experience postoperative improvement in depression or anxiety, 2 important components of quality of life (QOL). Thus, to examine other possible explanations for the lack of a post-DBS correlation between improved objective motor function and decreased depression or anxiety, the authors investigated whether patient perceptions of motor symptom severity might contribute to disease-associated depression and anxiety...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29465562/subacute-onset-leukodystrophy-and-visual-spatial-disorders-revealing-phenylketonuria-combined-with-homocysteinmia-in-adulthood-a-case-report
#3
Chunchen Wang, Jieying Li
RATIONALE: Phenylketonuria (PKU) is a metabolic disorder, which manifests a progressive irreversible neurological impairment during infancy and childhood. Hyperhomocysteinemia also showed that it might be involved in pathophysiology of many neuropsychiatric disorders. The late-onset clinical manifestations of these 2 diseases have not been reported elsewhere. We speculated that the late-onset PKU is caused by 2 kinds of metabolic dysfunction synergistically, especially a short period of irregular diet directly caused clinical symptoms...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464374/heterogeneous-pattern-of-autonomic-dysfunction-in-parkinson-s-disease
#4
Laurène Leclair-Visonneau, Laurent Magy, Christelle Volteau, Thomas Clairembault, Séverine Le Dily, Cécile Préterre, Arnaud Peyre, Philippe Damier, Michel Neunlist, Yann Péréon, Pascal Derkinderen
Dysautonomic symptoms are frequent non-motor complaints in patients with Parkinson's disease. Numerous neuropathological studies have shown that Lewy bodies and neurites, the pathological hallmarks of Parkinson's disease, are widely distributed throughout the peripheral autonomic nervous systems and across end organs. However, few investigations integrally explored the symptoms and physiology of dysautonomia in Parkinson's disease. We, therefore, performed a comprehensive evaluation of the autonomic function in a prospective group of 45 patients with idiopathic Parkinson's disease...
February 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29464188/glycine-receptor-modulating-antibody-predicting-treatable-stiff-person-spectrum-disorders
#5
Shannon R Hinson, A Sebastian Lopez-Chiriboga, James H Bower, Joseph Y Matsumoto, Anhar Hassan, Eati Basal, Vanda A Lennon, Sean J Pittock, Andrew McKeon
Background: Glycine receptor alpha-1 subunit (GlyRα1)-immunoglobulin G (IgG) is diagnostic of stiff-person syndrome (SPS) spectrum but has been reported detectable in other neurologic diseases for which significance is less certain. Methods: To assess GlyRα1-IgGs as biomarkers of SPS spectrum among patients and controls, specimens were tested using cell-based assays (binding [4°C] and modulating [antigen endocytosing, 37°C]). Medical records of seropositive patients were reviewed...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29464140/a-case-report-of-recombinant-tissue-plasminogen-activator-use-in-a-span-100-positive-geriatric-patient-with-thrombocytopenia
#6
Ilya Bragin, Justine M Chen
Thrombocytopenia (platelet count: < 100,000/mm3 ) is considered a contraindication in the use of intravenous thrombolysis for acute ischemic stroke. Little literature exists regarding tissue plasminogen activator (tPA) usage in thrombocytopenic patients, especially in older patients. Age and stroke severity are major prognostic indicators of the risk of hemorrhagic transformation. The Stroke Prognostication using Age and NIH Stroke Scale (SPAN) index estimates a patient's risk of intracerebral hemorrhage (ICH) and clinical response to thrombolysis by combining age in years with the National Institutes of Health Stroke Scale (NIHSS) scores...
December 11, 2017: Curēus
https://www.readbyqxmd.com/read/29463338/a-novel-treatment-protocol-nocebo-hypothesis-cognitive-behavioural-therapy-nh-cbt-for-functional-neurological-symptom-disorder-conversion-disorder-a-retrospective-consecutive-case-series
#7
Matt Richardson, Gina Isbister, Brad Nicholson
BACKGROUND: Theories concerning the aetiology of functional neurological symptom disorder (FNSD; also known as conversion disorder) have historically inferred that psychological factors or dissociative states underlie patients' symptoms. Current psychological models of functional neurological symptoms suggest that some type of 'top-down' representations/beliefs are activated automatically (without conscious awareness), leading to symptoms. It is assumed that these representations or beliefs are similar to the idea 'I am neurologically damaged', as in our clinical experience, almost all patients have some reason to doubt the integrity of their neurological system...
February 21, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29462248/quality-of-life-analysis-of-the-mito-8-mango-bgog-ov1-ago-ovar2-16-engot-ov1-gcig-study-comparing-platinum-based-versus-non-platinum-based-chemotherapy-in-patients-with-partially-platinum-sensitive-recurrent-ovarian-cancer
#8
M C Piccirillo, G Scambia, A Bologna, S Signoriello, I Vergote, K Baumann, D Lorusso, V Murgia, R Sorio, G Ferrandina, C Sacco, G Cormio, E Breda, S Cinieri, D Natale, G Mangili, C Pisano, S C Cecere, M Di Napoli, V Salutari, F Raspagliesi, L Arenare, A Bergamini, J Bryce, G Daniele, C Gallo, S Pignata, F Perrone
Background: MITO-8 showed that prolonging platinum-free interval by introducing non-platinum-based chemotherapy (NPBC) does not improve prognosis of patients with partially platinum-sensitive recurrent ovarian cancer. Quality of life (QOL) was a secondary outcome. Patients and methods: Ovarian cancer patients recurring or progressing 6-12 months after previous platinum-based chemotherapy (PBC) were randomized to receive PBC or NPBC as first treatment. QOL was assessed at baseline, 3rd and 6th cycle, with the EORTC C-30 and OV-28 questionnaires...
February 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29462072/anterior-to-dorsal-root-entry-zone-myelotomy-adrezotomy-a-new-surgical-approach-for-the-treatment-of-ventrolateral-deep-intramedullary-spinal-cord-cavernous-malformations
#9
Jian Ren, Chuan He, Tao Hong, Xiaoyu Li, Yongjie Ma, Jiaxing Yu, Feng Ling, Hongqi Zhang
STUDY DESIGN: A retrospective review of prospectively collected data. OBJECTIVE: To confirm the feasibility of using anterior to dorsal root entry zone myelotomy (ADREZotomy), a new surgical approach, for the treatment of ventrolateral deep ISCCMs. SUMMARY OF BACKGROUND DATA: Surgical removal of ventrolateral deep intramedullary spinal cord cavernous malformations (ISCCMs) is highly risky and remains problematic. METHODS: The authors performed a retrospective study exploring the surgical removal of ventrolateral intrinsic ISCCMs using ADREZotomy in 10 patients...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29460636/neurological-physical-and-sociodemographic-correlates-of-employment-in-multiple-sclerosis-a-meta-analysis
#10
Larissa Gerhard, Diana S Dorstyn, Gregory Murphy, Rachel M Roberts
Illness severity and sociodemographic characteristics of 7,053 employees with multiple sclerosis and 11,043 peers not in the workforce were compared (Hedges' g with 95% confidence interval and p values). Pooled findings from 25 studies confirmed the main role of a relapsing-remitting disease course and higher education to employment. To a lesser extent, disease duration, fatigue and pain symptoms and age also differentiated the two groups. Vocational interventions for persons with multiple sclerosis should focus on job retention, including mechanisms to accommodate and facilitate functional independence...
February 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29458125/pluripotent-stem-cells-for-uncovering-the-role-of-mitochondria-in-human-brain-function-and-dysfunction
#11
REVIEW
Annika Zink, Josef Priller, Alessandro Prigione
Mitochondrial dysfunctions are a known pathogenetic mechanism of a number of neurological and psychiatric disorders. At the same time, mutations in genes encoding for components of the mitochondrial respiratory chain cause mitochondrial diseases, which commonly exhibit neurological symptoms. Mitochondria are therefore critical for the functionality of the human nervous system. The importance of mitochondria stems from their key roles in cellular metabolism, calcium handling, redox and protein homeostasis, and overall cellular homeostasis through their dynamic network...
February 16, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29455486/-anterior-cervical-hybrid-surgical-treatment-for-multilevel-cervical-spondylotic-myelopathy
#12
Bi-Shui Zhan, Xue-Sheng Jiang, Guo-Shun Zhou, Ya-Feng Ji
OBJECTIVE: To evaluate the clinical results of anterior cervical discectomy and reconstruction with a self-locking cage and internal fixation with short segmental plate for multilevel cervical spondylotic myelopathy. METHODS: From January 2012 to June 2015, a total of 106 patients received anterior cervical discectomy and reconstruction with a self-locking cage and internal fixation with short segmental plate were followed up. There were 71 males and 35 females, aged from 42 to 74 years old with an average of(55...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29450761/an-electroglottographical-analysis-based-discriminant-function-model-differentiating-multiple-sclerosis-patients-from-healthy-controls
#13
George D Vavougios, Triantafyllos Doskas, Kostas Konstantopoulos
Dysarthrophonia is a predominant symptom in many neurological diseases, affecting the quality of life of the patients. In this study, we produced a discriminant function equation that can differentiate MS patients from healthy controls, using electroglottographic variables not analyzed in a previous study. We applied stepwise linear discriminant function analysis in order to produce a function and score derived from electroglottographic variables extracted from a previous study. The derived discriminant function's statistical significance was determined via Wilk's λ test (and the associated p value)...
February 15, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29450484/neurological-manifestations-among-us-government-personnel-reporting-directional-audible-and-sensory-phenomena-in-havana-cuba
#14
Randel L Swanson, Stephen Hampton, Judith Green-McKenzie, Ramon Diaz-Arrastia, M Sean Grady, Ragini Verma, Rosette Biester, Diana Duda, Ronald L Wolf, Douglas H Smith
Importance: From late 2016 through August 2017, US government personnel serving on diplomatic assignment in Havana, Cuba, reported neurological symptoms associated with exposure to auditory and sensory phenomena. Objective: To describe the neurological manifestations that followed exposure to an unknown energy source associated with auditory and sensory phenomena. Design, Setting, and Participants: Preliminary results from a retrospective case series of US government personnel in Havana, Cuba...
February 15, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29445958/histopathological-and-behavioral-assessments-of-aging-effects-on-stem-cell-transplants-in-an-experimental-traumatic-brain-injury
#15
Jea-Young Lee, Roger Lin, Hung Nguyen, M Grant Liska, Trenton Lippert, Yuji Kaneko, Cesar V Borlongan
Traumatic brain injury (TBI) displays cognitive and motor symptoms following the initial injury which can be exacerbated by secondary cell death. Aging contributes significantly to the morbidity of TBI, with higher rates of negative neurological and behaviors outcomes. In the recent study, young and aged animals were injected intravenously with human adipose-derived mesenchymal stem cells (hADSCs) (Tx), conditioned media (CM), or vehicle (unconditioned media) following TBI. The beneficial effects of hADSCs were analyzed using various molecular and behavioral techniques...
February 15, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29445033/rett-syndrome-a-neurological-disorder-with-metabolic-components
#16
REVIEW
Stephanie M Kyle, Neeti Vashi, Monica J Justice
Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene methyl-CpG-binding protein 2 ( MECP2 ), a ubiquitously expressed transcriptional regulator. Despite remarkable scientific progress since its discovery, the mechanism by which MECP2 mutations cause RTT symptoms is largely unknown. Consequently, treatment options for patients are currently limited and centred on symptom relief. Thought to be an entirely neurological disorder, RTT research has focused on the role of MECP2 in the central nervous system...
February 2018: Open Biology
https://www.readbyqxmd.com/read/29442351/milk-alkali-syndrome-mas-as-a-complication-of-the-treatment-of-hypoparathyroidism
#17
Agata Skwarek, Janusz Pachucki, Tomasz Bednarczuk, Zuzanna Żurecka, Michał Popow
Milk-alkali syndrome (MAS), characterized by renal failure, metabolic alkalosis and hypercalcemia, is a severe and life-threatening complication of the treatment of hypoparathyroidism. The clinical course is often sudden and is not preceded by any prodromal symptoms. Occurrence does not depend on the duration of hypoparathyroidism treatment, although it is closely related to the applied therapy, especially the dose of calcium carbonate and active vitamin D preparations. Drugs influencing the glomerular filtration rate (angiotensin receptor blockers, sartans, aldosterone receptor antagonists, thiazide diuretics), lack of adequate routine control, changing the calcium carbonate supplementation, dehydration, a diet rich in pH-basic foods (i...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29438129/central-and-peripheral-processes-in-headache
#18
Adithya Varma, Saurabh Jain, Arshad Majid, Milena De Felice
PURPOSE OF REVIEW: Migraine is an extremely incapacitating collection of neurological symptoms that usually includes a severe, throbbing, recurring pain on one side of the head. The World Health Organization ranks migraine as the third most prevalent disease and the seventh commonest primary pain condition in the world. Trigeminovascular-mediated central sensitization has been implicated in the development of migraine symptoms including pain following light touch. This review explores the activation and sensitization of the brain systems that have emerged from recent studies and that contribute to migraine...
February 12, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29436489/-cryptogenic-drop-attacks-revisited-evidence-of-overlap-with-functional-neurological-disorder
#19
Ingrid Hoeritzauer, Alan J Carson, Jon Stone
OBJECTIVE: In their 1973 BMJ paper 'Cryptogenic Drop Attacks', Stevens and Matthews described 40, mostly middle-aged, female patients with drop attacks of unknown cause. Although clinically common, there has been little on this topic since. We aimed to determine clinical features, comorbidity and outcome of patients with drop attacks. METHODS: We carried out a retrospective review of patients with cryptogenic drop attacks seen consecutively by one clinician (JS) between 2006 and 2016...
February 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29435691/common-data-elements-collected-among-universities-for-sport-related-concussion-studies
#20
Jingzhen Yang, Corinne Peek-Asa, James M Noble, James Torner, Paul Schmidt, Martha L Cooper
BACKGROUND: Universities are increasingly implementing programs to effectively respond to and manage sport-related concussions (SRCs). One such effort is to develop common data elements (CDEs) and standardize data collection methods. The objectives of this study were to describe CDEs currently collected by Big Ten and Ivy League universities for SRC studies, and to compare the data collected with the core CDEs recommended by the National Institute of Neurological Disorders and Stroke (NINDS)...
February 12, 2018: Injury Epidemiology
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