Patricia Davenport, Hsuan-Hao Fan, Emily Nolton, Henry A Feldman, Viola Lorenz, Jorge Canas, Maikel Acosta-Zaldívar, William Yakah, Connie Arthur, Camilia Martin, Sean Stowell, Julia Koehler, Donald Mager, Martha Sola-Visner
BACKGROUND: Platelet transfusions (PTxs) are often given to septic preterm neonates at high platelet count thresholds in an attempt to reduce bleeding risk. However, the largest randomized controlled trial (RCT) of neonatal transfusion thresholds found higher mortality and/or major bleeding in infants transfused at higher thresholds. Using a murine model, we investigated the effects of adult PTx on neonatal sepsis-induced mortality, systemic inflammation, and platelet consumption. STUDY DESIGN AND METHODS: Polymicrobial sepsis was induced via intraperitoneal injection of cecal slurry preparations (CS1, 2, 3) into P10 pups...
June 2022: Transfusion