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tryptophan hydroxylase1

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https://www.readbyqxmd.com/read/24520366/acute-fluoxetine-treatment-induces-slow-rolling-of-leukocytes-on-endothelium-in-mice
#1
Nadine Herr, Maximilian Mauler, Thilo Witsch, Daniela Stallmann, Stefanie Schmitt, Julius Mezger, Christoph Bode, Daniel Duerschmied
OBJECTIVE: Activated platelets release serotonin at sites of inflammation where it acts as inflammatory mediator and enhances recruitment of neutrophils. Chronic treatment with selective serotonin reuptake inhibitors (SSRI) depletes the serotonin storage pool in platelets, leading to reduced leukocyte recruitment in murine experiments. Here, we examined the direct and acute effects of SSRI on leukocyte recruitment in murine peritonitis. METHODS: C57Bl/6 and Tph1-/- (Tryptophan hydroxylase1) mice underwent acute treatment with the SSRI fluoxetine or vehicle...
2014: PloS One
https://www.readbyqxmd.com/read/21288331/impaired-dermal-wound-healing-in-discoidin-domain-receptor-2-deficient-mice-associated-with-defective-extracellular-matrix-remodeling
#2
Elvira Olaso, Hsin-Chieh Lin, Li-Hsien Wang, Scott L Friedman
BACKGROUND: The wounding response relies on tightly regulated crosstalk between recruited fibroblasts and the collagenous extracellular matrix (ECM). Discoidin domain receptor 2 (DDR2) is a tyrosine kinase receptor for fibrillar collagen expressed during pathologic scarring, for example wound healing, arthritis and cancer. We have previously shown that DDR2 phosphorylation drives key wounding responses in skin fibroblasts including proliferation, chemotactic migration and secretion of both metalloproteinases and fibrillar collagen...
2011: Fibrogenesis & Tissue Repair
https://www.readbyqxmd.com/read/17663674/pulmonary-hypertension-and-the-serotonin-hypothesis-where-are-we-now
#3
REVIEW
M R MacLean
In the 1960s, serotonin (5HT) was associated with pulmonary arterial hypertension (PAH) caused by certain diet pills, but has recently been the subject of renewed interest in the field of PAH. Serotonin can be synthesised in the pulmonary endothelium with the rate-limiting step being the activity of tryptophan hydroxylase1 (Tph1). The serotonin is released and can then: (i) pass into the underlying pulmonary smooth muscle cells through the serotonin transporter (SERT) to initiate proliferation and/or (ii) activate serotonin receptors on pulmonary smooth muscle cells to evoke proliferation and/or contraction...
September 2007: International Journal of Clinical Practice. Supplement
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