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Transient acantholytic dermatosis

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https://www.readbyqxmd.com/read/27532022/grover-s-like-drug-eruption-in-a-patient-with-metastatic-melanoma-under-ipilimumab-therapy
#1
Viktor H Koelzer, Tobias Buser, Niels Willi, Sacha I Rothschild, Andreas Wicki, Peter Schiller, Gieri Cathomas, Alfred Zippelius, Kirsten D Mertz
BACKGROUND: Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand 1 (PD-L1). Skin toxicity most commonly includes a maculopapular erythematous rash and pruritus. Rarely life threatening complications such as Steven's Johnson syndrome or toxic epidermal necrolysis may occur. CASE PRESENTATION: Here we report the uncommon event of a drug-induced transient acantholytic dermatosis (Grover's disease) in a 73-year-old Caucasian male treated with ipilimumab for metastatic melanoma...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27358215/transient-acantholytic-dyskeratosis-grover-s-disease-after-bone-marrow-transplantation
#2
Penny Poh Lu Lim, Pablo Fernandez Penas, David Gottlieb
Cutaneous eruptions in recipients of allogeneic haematopoietic stem cell transplantation (AHSCT) are frequent, and common aetiologies include graft-versus-host disease (GVHD), drug reactions, viral infections and engraftment syndrome. Transient acantholytic dermatosis or Grover's disease has been described in oncology patients and it is rarely reported after AHSCT. However, this benign and self-limiting condition should be histologically distinguished from other, more serious entities, mainly stage IV GVHD, in order to avoid inappropriate treatment with corticosteroids and intensive immunosuppression...
June 30, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/25396080/epidermal-multinucleated-giant-cells-are-not-always-a-histopathologic-clue-to-a-herpes-virus-infection-multinucleated-epithelial-giant-cells-in-the-epidermis-of-lesional-skin-biopsies-from-patients-with-acantholytic-dermatoses-can-histologically-mimic-a-herpes
#3
REVIEW
Philip R Cohen, Taraneh Paravar, Robert A Lee
BACKGROUND: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. PURPOSE: To review the histologic differential diagnosis of conditions with epithelial and histiocytic multinucleated giant cells-since multinucleated giant cells in the epidermis are not always pathognomonic of a cutaneous herpes virus infection-and to summarize dermatoses in which herpes virus infection has been observed to coexist...
October 2014: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/24442041/malassezia-skin-diseases-in-humans
#4
E M Difonzo, E Faggi, A Bassi, E Campisi, M Arunachalam, G Pini, F Scarfì, M Galeone
Although Malassezia yeasts are a part of the normal microflora, under certain conditions they can cause superficial skin infection, such as pityriasis versicolor (PV) and Malassezia folliculitis. Moreover the yeasts of the genus Malassezia have been associated with seborrheic dermatitis and dandruff, atopic dermatitis, psoriasis, and, less commonly, with confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis. The study of the clinical role of Malassezia species has been surrounded by controversy due to the relative difficulty in isolation, cultivation, and identification...
December 2013: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/24327039/pruritus-in-the-older-patient-a-clinical-review
#5
REVIEW
Timothy G Berger, Melissa Shive, G Michael Harper
IMPORTANCE: Pruritus is a common problem among elderly people and, when severe, causes as much discomfort as chronic pain. Little evidence supports pruritus treatment, limiting therapeutic possibilities and resulting in challenging management problems. OBJECTIVES: To present the evidence on the etiology, diagnosis, and treatment of pruritus in the elderly and, using the best available evidence, provide an approach for generalist physicians caring for older patients with pruritus...
December 11, 2013: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/24152615/grover-disease-transient-acantholytic-dermatosis-in-acute-myeloid-leukemia-on-fdg-pet-ct
#6
Hongyun June Zhu, Lindsey N Clark, Linda A Deloney, James E McDonald
A 48-year-old man with a newly diagnosed acute myeloid leukemia developed purpuric rash on day 6 after chemotherapy. Skin biopsy on day 8 demonstrated Grover disease. Triamcinolone treatment started on day 10 with subjective improvement on day 15. Initial FDG PET/CT on day 12 demonstrated rarely seen diffuse skin uptake that was interpreted as technical artifact and repeated on day 16. Accurately reviewing both PET and CT imaging would prevent confusion between diffuse cutaneous hypermetabolic activity and a technical artifact...
February 2014: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/24131368/is-grover-s-disease-an-autoimmune-dermatosis
#7
Courtney Phillips, Mina Kalantari-Dehaghi, Steve Marchenko, Alex I Chernyavsky, Valentin Galitovskiy, Vivian Gindi, Sookhee Chun, David Paslin, Sergei A Grando
Grover's disease (GD) is a transient or persistent, monomorphous, papulovesicular, asymptomatic or pruritic eruption classified as non-familial acantholytic disorder. Contribution of autoimmune mechanisms to GD pathogenesis remains controversial. The purpose of this study was to investigate antibody-mediated autoimmunity in 11 patients with GD, 4 of which were positive for IgA and/or IgG antikeratinocyte antibodies by indirect immunofluorescence. We used the most sensitive proteomic technique for an unbiased analysis of IgA- and IgG-autoantibody reactivities...
December 2013: Experimental Dermatology
https://www.readbyqxmd.com/read/23783409/transient-acantholytic-dermatosis-grover-s-disease-with-an-isolated-eruption
#8
LETTER
Sei-ichiro Motegi, Akihiko Uchiyama, Osamu Ishikawa
No abstract text is available yet for this article.
May 2013: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/23320241/grover-s-disease-after-heart-transplantation-a-case-report
#9
Giovanbattista Ippoliti, Marco Paulli, Marco Lucioni, Andrea Maria D'Armini, Marinella Lauriola, Rany Mahrous Haleem Saaleb
Grover's disease is a transient acantholytic dermatosis of unknown cause, manifesting clinically as a papular skin eruption that is usually located on the anterior chest and abdomen. Histologically characterized by an acantholytic pattern, it has been associated with numerous disorders, including hematologic malignancies, chronic renal failure, and HIV infection, as well as with chemotherapy and bone marrow and/or kidney transplant. Evaluation of followup and treatment is often complicated by spontaneous remission and the occasionally fluctuant course of the disease...
2012: Case Reports in Transplantation
https://www.readbyqxmd.com/read/22106724/grover-disease-transient-acantholytic-dermatosis-induced-by-anastrozole
#10
Joel S Crockett, Nicole M Burkemper
We present the case of a 79-year-old woman with a history of breast cancer who developed Grover disease (transient acantholytic dermatosis) following initiation of an aromatase inhibitor, anastrozole, as adjunctive treatment of her breast cancer. A number of drugs have been associated with this condition; however, to our knowledge, this case is the first report of anastrozole-induced Grover disease.
October 2011: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/21252638/atypical-variant-of-galli-galli-disease-grover-like-eruption-with-lentiginous-freckling-in-a-liver-transplant-patient
#11
Franco Rongioletti, Valentina Fausti, Konstantina Christana, Martina Montinari, Aurora Parodi, Roberto Fiocca
Galli-Galli disease is considered as a rare variant of Dowling-Degos disease, sharing the same clinical features of reticulate hyperpigmentation of the flexures. Histopathologically, there is acantholysis and suparabasal lacunae. Grover disease (transient acantholytic dermatosis) is a transient dermatosis which clinically presents as an eruption of erythematous excoriated papules located on the trunk and histologically with dyskeratosis and acantholysis. Grover disease has occasionally been reported in patients with chronic renal failure, human immunodeficiency virus infection, hematological malignancies, bone marrow allotransplantation, and renal transplantation...
July 2011: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/21242761/leukemia-cutis-in-association-with-grover-s-disease
#12
Bishr Aldabagh, Rishi R Patel, Kord Honda
Grover's disease (GD), or transient acantholytic dermatosis, is a persistent recurrent dermatosis that usually occurs in men older than 50 years. Rare cases of GD and hematologic malignancy in the same cutaneous biopsy specimen have been reported. We report a case of GD in association with leukemia cutis. A 72-year-old man with a history of myelodysplastic syndrome presented with numerous pruritic papules on the torso, which were clinically diagnosed as GD. A skin biopsy revealed foci of suprabasal acantholysis and dyskeratosis consistent with GD and dense aggregates of mononuclear atypical cells in the superficial dermis consistent with leukemia cutis...
June 2011: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/20526170/grover-disease-a-reappraisal-of-histopathological-diagnostic-criteria-in-120-cases
#13
María-Teresa Fernández-Figueras, Luis Puig, Pablo Cannata, Miriam Cuatrecases, Ariadna Quer, Carlos Ferrándiz, Aurelio Ariza
Grover disease (GD) is a rather common papular pruritic dermatosis that can be transient, persistent, or asymptomatic. The microscopic diagnosis of clinically suspected lesions can be challenging because GD can adopt different patterns, and involved areas are generally admitted to be mostly focal. The histopathologic hallmark of the disease is acantholysis, frequently combined with dyskeratosis, which confers the lesions an appearance similar to Darier disease, Hailey-Hailey disease, or pemphigus. Eczematous features can be observed as well...
August 2010: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/19722762/grover-disease-transient-acantholytic-dermatosis
#14
REVIEW
Joshua Weaver, Wilma F Bergfeld
Grover disease, also known as transient acantholytic dermatosis, is a papulovesicular rash of the upper trunk, generally among older white males; it is usually pruritic but temporary. Grover disease is characterized by 4 different acantholytic histologic patterns, and it has been associated with numerous disorders, including hematologic malignancies. Follow-up and treatment are often difficult to evaluate secondary to the spontaneous remittance and occasional fluctuant course of the disease. Our objective will be to discuss the diagnostic considerations of Grover disease and focus on the postulated pathogenesis, including concurrent disorders and the role of the pathologist in examining skin biopsies of this nonhereditary vesicobullous disorder...
September 2009: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/18429645/occult-herpes-simplex-virus-colonization-of-bullous-dermatitides
#15
Arjen F Nikkels, Philippe Delvenne, Michael Herfs, Gérald E Pierard
BACKGROUND: Acantholytic disorders, including pemphigus vulgaris, chronic benign familial pemphigus (Hailey-Hailey disease, superficial pemphigus), Darier disease, and Grover transient acantholytic dermatosis, as well as other vesiculo-bullous disorders, including bullous pemphigoid, epidermolysis bullosa, and atopic dermatitis, are prone to florid infections by herpes simplex virus (HSV)-I and -II, and, more rarely, by varicella-zoster virus (VZV). As these infections are difficult to recognize clinically and histologically, their frequency remains unknown...
2008: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/18222327/galli-galli-disease-a-case-report-with-review-of-the-literature
#16
REVIEW
Heidi Gilchrist, Scott Jackson, Lisa Morse, Thomas Nicotri, Lee T Nesbitt
Galli-Galli disease is a rare variant of the genodermatosis Dowling-Degos disease with the histologic finding of acantholysis. We present the case of a patient who presented with reticulated pigmentary changes in the flexures as well as a pruritic papular eruption and histologic features consistent with Galli-Galli disease. A literature search revealed 3 previous case reports of Galli-Galli disease. These case reports were reviewed and summarized, and the clinical and histologic presentations were compared with those of our patient...
February 2008: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/17725068/antibiotic-ointment-in-the-treatment-of-grover-disease
#17
Kell N Julliard, Peter B Milburn
Grover disease, or transient acantholytic dermatosis, chiefly affects the upper part of the trunk in men older than 40 years. Lesions may last for weeks, months, or years, and often are accompanied by intense pruritus. Some patients respond to topical steroid treatment but many do not. This article reports major or total resolution of Grover disease in 6 of 9 patients following topical application of a triple antibiotic ointment. It also proposes using a case registry as a way of further investigating the efficacy of this treatment so that dermatologists may participate...
July 2007: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/16844509/seasonal-variation-of-transient-acantholytic-dyskeratosis-grover-s-disease
#18
Noah Scheinfeld, Joan Mones
BACKGROUND: Grover's disease (GD), or transient acantholytic dermatosis, is a pruritic, papulovesicular eruption characterized histopathologically by acantholysis with or without dyskeratosis. The origin of GD is unknown. Suggested causes include sweating, heat, immobilization occlusion, external beam and ultraviolet radiation, and xerosis. GD has also been found to occur in association with other diseases. OBJECTIVE: Our aim was to assess whether GD exhibits seasonal variation and, if so, to determine whether any inferences can be drawn from its seasonal variation regarding its cause...
August 2006: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/16778425/grover-s-disease-induced-by-cetuximab
#19
G G Tscharner, S Bühler, M Borner, T Hunziker
A 71-year-old man exhibited an acute acneiform rash affecting the face and the upper trunk about 2 weeks after starting cetuximab, an epidermal growth factor (EGF) receptor antagonist treatment for metastatic colon cancer. The skin eruption faded after stopping cetuximab and applying topical corticosteroids. The reexposure to cetuximab 3 weeks later provoked a more extended relapse of the skin rash, which then clinically and histologically corresponded to transient acantholytic dermatosis . While the acneiform cutaneous side effects of the EGF receptor antagonists are interpreted as a result of the direct interference with pilosebaceous follicle homeostasis, in this case an acrosyringium-related pathogenesis might be postulated...
2006: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/16620222/transient-acantholytic-dermatosis-grover-s-disease-in-a-renal-transplant-patient
#20
Fotini Boutli, Maria Voyatzi, Ioanna Lefaki, Giorgos Chaidemenos, Jean Kanitakis
Grover's disease ("transient acantholytic dermatosis") is a transient dermatosis of unknown cause manifesting clinically as a papular skin eruption located usually on the anterior chest and abdomen and histologically with dyskeratosis and acantholysis. Grover's disease has occasionally been reported in patients with chronic renal failure, HIV infection, hematological malignancies and bone-marrow allotransplantation. We report herein a new case of Grover's disease that developed in a renal transplant patient...
March 2006: Journal of Dermatology
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