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Asia T McCleary-Gaddy, Carol T Miller, Kristie W Grover, James J Hodge, Brenda Major
Background: Stigmatized people exhibit blunted cortisol responses to many stressors. Purpose: To examine the cortisol responses of individuals who are overweight to a stigma-related stressor involving interviewing for a weight-discriminatory company. Methods: We recruited 170 men and women (mean age = 35.01) from towns located within about a 30-min drive of the study center. Weight was assessed using body mass index (BMI) and self-perceptions about being overweight...
June 16, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Oscar Calzada, Jeffrey M Switchenko, Joseph J Maly, Kristie A Blum, Natalie Grover, Stephanie Mathews, Steven I Park, Max Gordon, Alexey Danilov, Narendranath Epperla, Timothy S Fenske, Mehdi Hamadani, Christopher R Flowers, Jonathon B Cohen
Prospective identification of candidates for deferred therapy is not standardized and many patients receive immediate therapy regardless of risk. We conducted a retrospective, multi-center cohort analysis of MCL patients with comprehensive clinical data to examine the use and safety of deferred therapy for newly diagnosed patients. Previously untreated patients ≥18 years-old with MCL diagnosed in 1993-2015 at five academic sites were included. Of 395 patients, 72 (18%) received deferred therapy (defined as receipt of first treatment >90 days following initial diagnosis)...
June 18, 2018: Leukemia & Lymphoma
E Ann Yeh, Nicole Chiang, Bindia Darshan, Nadine Nejati, Stephanie A Grover, Carolyn E Schwartz, Ruth Slater, Marcia Finlayson
Rates of medication nonadherence in youth with multiple sclerosis (MS) range from 10% to 60%. Qualitative studies of adherence can provide insight into children's own perspectives about barriers and facilitators to their adherence and inform future interventions. This qualitative longitudinal descriptive study included children with MS ( n = 28) participating in a randomized controlled trial focused on medication adherence ( : NCT02234713). Following established methods, three independent reviewers coded transcripts of motivational interviewing (MI) sessions (three interviews per subject, performed monthly over a 3-month period) for relevant themes...
June 1, 2018: Qualitative Health Research
Anil Pareek, Indranil Purkait, Anu Grover, Ravi Tejraj Mehta
No abstract text is available yet for this article.
March 2018: Indian Journal of Endocrinology and Metabolism
Yogesh Bhattarai, Brianna B Williams, Eric J Battaglioli, Weston R Whitaker, Lisa Till, Madhusudan Grover, David R Linden, Yasutada Akiba, Karunya K Kandimalla, Nicholas C Zachos, Jonathan D Kaunitz, Justin L Sonnenburg, Michael A Fischbach, Gianrico Farrugia, Purna C Kashyap
Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine in the gastrointestinal (GI) tract remains unknown. Here, we show that the biological effects of tryptamine are mediated through the 5-HT4 receptor (5-HT4 R), a G-protein-coupled receptor (GPCR) uniquely expressed in the colonic epithelium. Tryptamine increases both ionic flux across the colonic epithelium and fluid secretion in colonoids from germ-free (GF) and humanized (ex-GF colonized with human stool) mice, consistent with increased intestinal secretion...
June 13, 2018: Cell Host & Microbe
Shoko Edogawa, Stephanie A Peters, Gregory D Jenkins, Sakteesh V Gurunathan, Wendy J Sundt, Stephen Johnson, Ryan J Lennon, Roy B Dyer, Michael Camilleri, Purna C Kashyap, Gianrico Farrugia, Jun Chen, Ravinder J Singh, Madhusudan Grover
Intestinal barrier function and microbiota are integrally related and play critical roles in maintenance of host physiology. Sex is a key biologic variable for several disorders. Our aim was to determine sex-based differences in response to perturbation and subsequent recovery of intestinal barrier function and microbiota in healthy humans. Twenty-three volunteers underwent duodenal biopsies, mucosal impedance, and in vivo permeability measurement. Permeability testing was repeated after administration of indomethacin, then 4 to 6 wk after its discontinuation...
June 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Neo M Tapela, Michael J Peluso, Racquel E Kohler, Irene I Setlhako, Kerapetse Botebele, Kemiso Gabegwe, Isaac Nkele, Mohan Narasimhamurthy, Mompati Mmalane, Surbhi Grover, Tomer Barak, Lawrence N Shulman, Shahin Lockman, Scott Dryden-Peterson
Introduction: Health system delays in diagnosis of cancer contribute to the glaring disparities in cancer mortality between high-income countries and low- and middle-income countries. In Botswana, approximately 70% of cancers are diagnosed at late stage and median time from first health facility visit for cancer-related symptoms to specialty cancer care was 160 days (IQR 59-653). We describe the implementation and early outcomes of training targeting primary care providers, which is a part of a multi-component implementation study in Kweneng-East district aiming to enhance timely diagnosis of cancers...
2018: Frontiers in Oncology
Prabina K Meher, Tanmaya K Sahu, Jyotilipsa Mohanty, Shachi Gahoi, Supriya Purru, Monendra Grover, Atmakuri R Rao
As inorganic nitrogen compounds are essential for basic building blocks of life (e.g., nucleotides and amino acids), the role of biological nitrogen-fixation (BNF) is indispensible. All nitrogen fixing microbes rely on the same nitrogenase enzyme for nitrogen reduction, which is in fact an enzyme complex consists of as many as 20 genes. However, the occurrence of six genes viz., nifB, nifD, nifE, nifH, nifK , and nifN has been proposed to be essential for a functional nitrogenase enzyme. Therefore, identification of these genes is important to understand the mechanism of BNF as well as to explore the possibilities for improving BNF from agricultural sustainability point of view...
2018: Frontiers in Microbiology
Shefali R Gajjar, Eric A Mellon, Serguei A Castaneda, Sigfredo Romero Zoghbi, Ricardo Llorente, Vincent DeGennaro, Surbhi Grover, Nalia Cruz Ventura
No abstract text is available yet for this article.
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Robin Keegan, Leslie T Grover, David Patron, Olivia K Sugarman, Krystal Griffith, Suzy Sonnier, Benjamin F Springgate, Lauren Crapanzano Jumonville, Sarah Gardner, Willie Massey, Jeanne Miranda, Bowen Chung, Kenneth B Wells, Stephen Phillippi, Ed Trapido, Alexa Ramirez, Diana Meyers, Catherine Haywood, Craig Landry, Ashley Wennerstrom
BACKGROUND: Addressing behavioral health impacts of major disasters is a priority of increasing national attention, but there are limited examples of implementation strategies to guide new disaster responses. We provide a case study of an effort being applied in response to the 2016 Great Flood in Baton Rouge. METHODS: Resilient Baton Rouge was designed to support recovery after major flooding by building local capacity to implement an expanded model of depression collaborative care for adults, coupled with identifying and responding to local priorities and assets for recovery...
June 8, 2018: International Journal of Environmental Research and Public Health
Sandeep Grover, Aseem Mehra, Eish Dalla, Subho Chakrabarti, Ajit Avasthi
This naturalistic study aimed to assess treatment dropout pattern, course of symptoms and outcome of depression among the elderly. This study aimed to assess the course and outcome of depression and treatment dropout pattern of patients with depression in old age. Additionally an attempt was made to study the predictors of outcome and dropout. 140 elderly patients (≥ 60 years) were followed up at 6 months and 1 year to evaluate the status of their depression and treatment pattern. Out of the 140 patients recruited at the baseline, 58 (41...
June 1, 2018: Psychiatry Research
Himanshu Singla, Sandeep Grover
Electroconvulsive therapy (ECT) is one of the safest treatment options for psychiatric illnesses with no absolute contraindications. However, certain medical conditions including cardiac ailments such as aortic stenosis are associated with increased risk with ECT. We present the case of a 74-year-old female who was suffering from severe depression with psychotic symptoms (which had not responded to two adequate trials of antidepressants), along with severe aortic stenosis, who was managed with modified bilateral ECT and review the available literature...
May 2018: Indian Journal of Psychological Medicine
Sandeep Grover, Aseem Mehra
Incubus syndrome, characterized by delusional belief in female patients of being sexually approached by an unforeseen person, is rarely described in literature and description has been limited to isolated case reports. We describe four patients with schizophrenia, who reported the phenomenon of incubus and responded well to treatment with antipsychotics. A review of literature yielded five reports (describing six cases), most of which were described in the context of schizophrenia.
May 2018: Indian Journal of Psychological Medicine
Aseem Mehra, Debashish Basu, Sandeep Grover
The mind-altering agents such as tobacco, cannabis, and opium have been widely used since the evolution of human being. These substances have been widely used for recreational purposes. However, derivatives from reptiles such as snakes, reptiles, and scorpions can also be used for recreational purposes and as a substitute for other substances. Their use is rare and related literature is very scanty. In this report, we present a case of snake venom abuse and review the existing literature.
May 2018: Indian Journal of Psychological Medicine
Athos Patsalides, Cristiano Oliveira, Jessica Wilcox, Kenroy Brown, Kartikey Grover, Yves Pierre Gobin, Marc J Dinkin
AIMS: We report the cerebrospinal fluid opening pressure (CSF-OP) measurements obtained before and after venous sinus stenting (VSS) in 50 patients with idiopathic intracranial hypertension. METHODS: The CSF-OP was measured with a spinal tap 3 months before and 3 months after treatment. All data were prospectively collected and included patient demographics, weight (kg), body mass index (BMI), acetazolamide daily dosage (mg), procedural details, complications, venous sinus pressures (mm Hg), trans-stenotic pressure gradient (mm Hg), transverse sinus symmetry, and type of venous sinus stenosis...
June 5, 2018: Journal of Neurointerventional Surgery
Rebecca F Hough, Sunita Bhattacharya, Jahar Bhattacharya
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
Soumya Jhanda, Savita Malhotra, Sandeep Grover
OBJECTIVES: This study aimed to evaluate the impact of comorbid attention deficit hyperkinetic disorder (ADHD) on Bipolar disorder (BD). METHODS: Patients aged 13-40 years with diagnosis of BD with ADHD (N = 30) were compared to those with BD without ADHD (N = 69) for clinical course, functional outcome and quality of life. RESULTS: Those with BD + ADHD had significantly lower age of onset of BD (p < 0.001), a significantly higher number of total lifetime episodes (p = 0...
May 19, 2018: Asian Journal of Psychiatry
Swapnajeet Sahoo, Sandeep Grover, Ritu Nehra
BACKGROUND: Neurocognitive deficits have been well documented in patients with schizophrenia. Research has shown that a significant proportion of patients with schizophrenia have co-morbid obsessive-compulsive symptoms/disorder (OCS/OCD). However, the impact of OCS/OCD on various neurocognitive domains in patients with schizophrenia is less understood. METHODS: 40 patients with schizophrenia and comorbid OCD (Group-I) were matched with 39 patients with schizophrenia without OCD (Group-II) and were assessed on Trail making test A and B (TMT-A/B), Controlled Oral Word Association test (COWA), Stroop test and Tower of London (TOL)...
May 29, 2018: Schizophrenia Research
Viswas Dayal, Timothy Grover, Patricia Limousin, Harith Akram, Davide Cappon, Joseph Candelario, Maricel Salazar, Elina Tripoliti, Ludvic Zrinzo, Jonathan Hyam, Marjan Jahanshahi, Marwan Hariz, Thomas Foltynie
BACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) is an established treatment for selected Parkinson's disease (PD) patients, but therapy is often limited by side effects. Previous studies indicate an inverse relationship of the therapeutic window (TW) to pulse width (PW) settings down to 60μs, but there is limited data available on the effect of shorter PWs. OBJECTIVE: To define the TW of STN-DBS in PD at PW of 30μs (PW30) relative to standard PW settings at 60μs (PW60), and to compare speed of gait and speech intelligibility on the two PW conditions...
May 19, 2018: Journal of Parkinson's Disease
Michael F Bode, Alyson C Auriemma, Steven P Grover, Yohei Hisada, Alex Rennie, Weeranun D Bode, Rashi Vora, Saravanan Subramaniam, Brian Cooley, Patricia Andrade-Gordon, Silvio Antoniak, Nigel Mackman
INTRODUCTION: Rivaroxaban selectively inhibits factor Xa (FXa), which plays a central role in blood coagulation. In addition, FXa activates protease-activated receptor-2 (PAR-2). We have shown that PAR-2-/- mice exhibit less cardiac dysfunction after cardiac injury. MATERIAL AND METHODS: Wild-type (WT) and PAR-2-/- mice were subjected to left anterior descending artery (LAD) ligation to induce cardiac injury and heart failure. Mice received either placebo or rivaroxaban chow either starting at the time of surgery or 3 days after surgery and continued up to 28 days...
May 17, 2018: Thrombosis Research
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