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https://www.readbyqxmd.com/read/29456305/a-clinicoradiographic-assessment-of-1-metformin-gel-with-platelet-rich-fibrin-in-the-treatment-of-mandibular-grade-ii-furcation-defects
#1
Parul Sharma, Harpreet Singh Grover, Sujata Surendra Masamatti, Neha Saksena
Background: Management of furcation defects is challenging, and constantly newer therapeutic strategies are evolving. Platelet-rich fibrin (PRF) is successfully used alone and in combination with various agents in the furcation defects. Lately, metformin (MF), a second generation biguanide has gained popularity owing to its osteogenic potential. Aims and Objectives: The aim of the present study was to evaluate the clinical and radiographic effectiveness of open flap debridement (OFD) and PRF when compared to OFD + PRF + 1% MF gel in the management of mandibular Grade II furcation defects...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29455676/evaluation-of-an-ophthalmoscopy-simulator-to-teach-funduscopy-skills-to-pediatric-residents
#2
Elizabeth Kouzmitcheva, Stephanie A Grover, Tara Berenbaum, Asim Ali, Adelle Atkinson, E Ann Yeh
BACKGROUND: Medical school and residency training in ophthalmoscopic evaluation is limited, reducing diagnostic accuracy. We sought to evaluate the efficacy of self-study using an ophthalmoscopy simulator to improve the technical motor skills involved in direct funduscopy in postgraduate pediatric residents. METHODS: In this randomized-controlled study, 17 pediatric residents (postgraduate years 1-3) were randomized to control (n=8) or intervention (n=9) groups...
February 19, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29453664/analysis-of-transactivation-potential-of-rice-oryza-sativa-l-heat-shock-factors
#3
Dhruv Lavania, Anuradha Dhingra, Anil Grover
Based on yeast one-hybrid assays, we show that the presence of C-terminal AHA motifs is not a prerequisite for transactivation potential in rice heat shock factors. Transcriptional activation or transactivation (TA) of heat stress responsive genes takes place by binding of heat shock factors (Hsfs) to heat shock elements. Analysis of TA potential of thirteen rice (Oryza sativa L.) Hsfs (OsHsfs) carried out in this study by yeast one-hybrid assay showed that OsHsfsA3 possesses strong TA potential while OsHsfs A1a, A2a, A2b, A4a, A4d, A5, A7b, B1, B2a, B2b, B2c and B4d lack TA potential...
February 16, 2018: Planta
https://www.readbyqxmd.com/read/29443962/a-programmable-two-qubit-quantum-processor-in-silicon
#4
T F Watson, S G J Philips, E Kawakami, D R Ward, P Scarlino, M Veldhorst, D E Savage, M G Lagally, Mark Friesen, S N Coppersmith, M A Eriksson, L M K Vandersypen
Now that it is possible to achieve measurement and control fidelities for individual quantum bits (qubits) above the threshold for fault tolerance, attention is moving towards the difficult task of scaling up the number of physical qubits to the large numbers that are needed for fault-tolerant quantum computing. In this context, quantum-dot-based spin qubits could have substantial advantages over other types of qubit owing to their potential for all-electrical operation and ability to be integrated at high density onto an industrial platform...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29443699/grover-disease-with-epidermal-dysmaturation-pattern-a-common-histopathologic-finding
#5
Ohoud Z Aljarbou, Masoud Asgari, Nagla Al-Saidi, Elizabeth O Silloca-Cabana, Mamoun Alathamneh, Omar Sangueza
BACKGROUND: Grover disease is an entity whose diagnosis is based on clinicopathologic correlation. Histopathologically, focal acantholysis is the most common finding. In some cases, there is prominent squamous atypia which can prove to be very challenging and the lesion may be confused with an epidermal neoplasm. OBJECTIVE: To report on atypical histopathological changes in Grover disease and to provide helpful clues to differentiate between the epidermal atypia seen in some cases of Grover disease and epithelial neoplasms...
February 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29441291/nail-biopsy-a-user-s-manual
#6
REVIEW
Chander Grover, Shikha Bansal
Nail biopsy is a procedure not routinely resorted to; but when indicated, it is often the only clue left for diagnosis. At such times, it pays to be conversant with it. It is an investigation that not only provides etiologic, diagnostic, and prognostic information but also aids in understanding the pathogenesis of nail diseases. It can be of therapeutic value, especially with respect to nail tumors. This article compiles the procedural techniques for nail biopsy of various types and attempts to summarize the evidence available in the literature...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29437578/tissue-factor-an-essential-mediator-of-hemostasis-and-trigger-of-thrombosis
#7
REVIEW
Steven P Grover, Nigel Mackman
Tissue factor (TF) is the high-affinity receptor and cofactor for FVII/VIIa. The TF-FVIIa complex is the primary initiator of blood coagulation and plays an essential role in hemostasis. TF is expressed on perivascular and epithelial cells at organ and body surfaces where it forms a hemostatic barrier. TF also provides additional hemostatic protection to vital organs, such as the brain, lung, and heart. Under pathological conditions, TF can trigger both arterial and venous thrombosis. For instance, atherosclerosis plaques contain high levels of TF on macrophage foam cells and microvesicles that drives thrombus formation after plaque rupture...
February 8, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29436410/gastric-outlet-obstruction-due-to-pyloric-mass-in-a-12-year-old-girl
#8
Bradley MacDonald, Sarah Rumore, Ajay Sharma, Zubin Grover
No abstract text is available yet for this article.
February 7, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29436045/spontaneous-resolution-of-labial-adhesions-in-pre-pubertal-girls
#9
Jean E Norris, Charlotte V Elder, Angela M Dunford, Deepti Rampal, Charleen Cheung, Sonia R Grover
AIMS: This study sought to observe the rate and timing of spontaneous resolution of labial adhesions that had been diagnosed in pre-pubertal girls. The secondary aim was to evaluate the conservative approach to management of labial adhesions that has been advocated by the Gynaecology Department, by assessing the rates of concurrent uro-gynaecological symptoms in this population, as well as parent satisfaction with their child's management. METHODS: A retrospective chart review was performed of all patients diagnosed with labial adhesions in the Department of Paediatric and Adolescent Gynaecology between 2000 and 2017...
February 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29433424/molecular-dynamics-simulations-revealed-structural-differences-among-wrky-domain-dna-interaction-in-barley-hordeum-vulgare
#10
Bharati Pandey, Abhinav Grover, Pradeep Sharma
BACKGROUND: The WRKY transcription factors are a class of DNA-binding proteins involved in diverse plant processes play critical roles in response to abiotic and biotic stresses. Genome-wide divergence analysis of WRKY gene family in Hordeum vulgare provided a framework for molecular evolution and functional roles. So far, the crystal structure of WRKY from barley has not been resolved; moreover, knowledge of the three-dimensional structure of WRKY domain is pre-requisites for exploring the protein-DNA recognition mechanisms...
February 12, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29430770/structuring-of-hydrogels-across-multiple-length-scales-for-biomedical-applications
#11
REVIEW
Megan E Cooke, Simon W Jones, Britt Ter Horst, Naiem Moiemen, Martyn Snow, Gurpreet Chouhan, Lisa J Hill, Maryam Esmaeli, Richard J A Moakes, James Holton, Rajpal Nandra, Richard L Williams, Alan M Smith, Liam M Grover
The development of new materials for clinical use is limited by an onerous regulatory framework, which means that taking a completely new material into the clinic can make translation economically unfeasible. One way to get around this issue is to structure materials that are already approved by the regulator, such that they exhibit very distinct physical properties and can be used in a broader range of clinical applications. Here, the focus is on the structuring of soft materials at multiple length scales by modifying processing conditions...
February 12, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29422472/evaluation-of-hemoglobin-concentration-and-hematocrit-values-in-temporomandibular-joint-ankylosis-patients-in-comparison-to-nonankylosed-patients
#12
Deepinder Singh, Guneet Kaur, Dipanshu Bakshi, Jasjit Sahota, Ambika Thakur, Shekhar Grover
AIM: The aim of this study is to find if there is any correlation between the hematological parameters and temporomandibular joint (TMJ) ankylosis and severity of the disease in such patients when compared with the nonankylosed patients. MATERIALS AND METHODS: A total of 70 patients with age ranging from 10 to 40 years were included in the study after excluding the subjects according to the inclusion criteria. We categorized the subjects into two major groups: group I: control (nonankylosed/ healthy subjects) and group II: study group (ankylosed subjects) with each group containing 35 subjects (n = 35) respectively...
February 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29422465/estimation-of-plasma-levels-of-tumor-necrosis-factor-a-interleukin-4-and-6-in-patients-with-chronic-periodontitis-and-type-ii-diabetes-mellitus
#13
Dipanshu Bakshi, Guneet Kaur, Deepinder Singh, Jasjit Sahota, Ambika Thakur, Shekhar Grover
INTRODUCTION: Both periodontitis and type II diabetes mellitus (T2DM) are common diseases with a multifactorial etiology and have influence of cytokines in their pathogenesis and thus may also influence each other. In recent times, more attention has been given to understanding the influences of these inflammatory cytokines which are a main part of oral chronic inflammation on systemic health of the individuals. Therefore, the aim of this study was to evaluate the plasma cytokine levels, specifically tumor necrosis factor-a (TNF-a), interleukin (IL)-6, and IL-4, in chronic periodontitis patients and T2DM patients, so as to investigate the influence of chronic periodontitis in systemic inflammation associated with diabetes mellitus...
February 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29421878/construction-of-a-coarse-grain-quasi-classical-trajectory-method-ii-comparison-against-the-direct-molecular-simulation-method
#14
R L Macdonald, M S Grover, T E Schwartzentruber, M Panesi
This work presents the analysis of non-equilibrium energy transfer and dissociation of nitrogen molecules (N2(Σg+1)) using two different approaches: the direct molecular simulation (DMS) method and the coarse-grain quasi-classical trajectory (CG-QCT) method. The two methods are used to study thermochemical relaxation in a zero-dimensional isochoric and isothermal reactor in which the nitrogen molecules are heated to several thousand degrees Kelvin, forcing the system into strong non-equilibrium. The analysis considers thermochemical relaxation for temperatures ranging from 10 000 to 25 000 K...
February 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29421342/more-than-grapes-and-bleeding-an-updated-look-at-pelvic-rhabdomyosarcoma-in-young-females
#15
Aalia Sachedina, Kiri Chan, Duncan MacGregor, Martin Campbell, Sonia R Grover
STUDY OBJECTIVE: To review our local experience with urogenital RMS to determine the most common clinical presentation(s). DESIGN: Retrospective case series of all cases of female urogenital RMS presenting to a tertiary pediatric hospital between 1996 and 2016. All institutional electronic pathology reports were screened for RMS and those that were pelvic in origin and occurring in female patients were included for further analysis. Seventeen cases of urogenital RMS in female patients were identified and reviewed...
February 5, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29416240/intensive-care-unit-delirium-a-wide-gap-between-actual-prevalence-and-psychiatric-referral
#16
Sandeep Grover, Siddharth Sarkar, Lakshmi Narayana Yaddanapudi, Abhishek Ghosh, Amit Desouza, Debasish Basu
Background and Aims: The study aimed to assess the rates of delirium in an Intensive Care Unit (ICU) prospectively assessed with a delirium screening instrument and confirmed through psychiatrist evaluation. In addition, the referral rate to psychiatric consultation liaison services from the same ICU was assessed through the rates of psychiatric referral over the previous 10 years. Material and Methods: In the prospective part of the study, consecutive patients aged 16 years or more admitted to the ICU of a tertiary care hospital were assessed daily for delirium using confusion assessment method for the ICU, a validated instrument that can be used for both mechanically ventilated and nonventilated patient by trained heath care personnel...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29414473/formulation-and-viscoelasticity-of-mineralised-hydrogels-for-use-in-bone-cartilage-interfacial-reconstruction
#17
Trina Majumdar, Megan E Cooke, Bernard M Lawless, Francis Bellier, Erik A B Hughes, Liam M Grover, Simon W Jones, Sophie C Cox
Articular cartilage is a viscoelastic tissue whose structural integrity is important in maintaining joint health. To restore the functionality of osteoarthritic joints it is vital that regenerative strategies mimic the dynamic loading response of cartilage and bone. Here, a rotating simplex model was employed to optimise the composition of agarose and gellan hydrogel constructs structured with hydroxyapatite (HA) with the aim of obtaining composites mechanically comparable to human cartilage in terms of their ability to dissipate energy...
January 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29414386/electroconvulsive-therapy-among-elderly-patients-a-study-from-tertiary-care-centre-in-north-india
#18
Sandeep Grover, Ashirbad Satapathy, Subho Chakrabarti, Ajit Avasthi
OBJECTIVE: This retrospective study aimed to evaluate the effectiveness and safety of ECT among elderly patients receiving electroconvulsive therapy (ECT). METHODS: During the study period of January 2008 to May 2017, 151 patients aged ≥60 years received ECT and they formed the study sample. Data on patients aged 19 to 59 years for the period of 3 years (2014-2016) was also extracted for comparison purposes. RESULTS: The mean age of the elderly subjects was 65...
January 31, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29413227/to-use-the-brief-psychiatric-rating-scale-to-detect-disorganized-speech-in-schizophrenia-findings-from-the-reap-ap-study
#19
Yong Chon Park, Shigenobu Kanba, Mian-Yoon Chong, Adarsh Tripathi, Roy Abraham Kallivayalil, Ajit Avasthi, Sandeep Grover, Kok Yoon Chee, Andi J Tanra, Marigarita M Maramis, Shu-Yu Yang, Norman Sartorius, Chay-Hoon Tan, Naotaka Shinfuku, Seon-Cheol Park
Our study aimed to assess the psychometric validity of the conceptual disorganization item and other items of the Brief Psychiatric Rating Scale (BPRS) for detecting disorganized speech in patients with schizophrenia. We included 357 schizophrenia patients with disorganized speech and 1082 without disorganized speech from the survey centers in India, Indonesia, Japan, Malaysia, and Taiwan, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. After adjusting the effects of confounding variables, a binary logistic regression model was fitted to identify BPRS items independently associated with disorganized speech...
February 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29409753/iodine-mediated-pyrazolo-quinoline-derivatives-as-potent-anti-proliferative-agents
#20
Suresh Kasaboina, Venkatesh Ramineni, Saleha Banu, Yadagiri Bandi, Lingaiah Nagarapu, Naresh Dumala, Paramjit Grover
A novel series of substituted pyrazolo-quinoline derivatives 7pa-7qg were synthesized efficiently by using molecular iodine in DMSO and further characterized based on 1H NMR, 13C NMR, IR and HRMS spectral studies. All the synthesized derivatives were screened for their in vitro cytotoxic activity against a panel of five different cancer cell lines such as A549, HeLa, SKNSH, HepG2 and MCF7. The compounds 7pc, 7pd, and 7pj exhibited considerable to promising anti-proliferative activity with IC50 values of 3.76, 3...
February 3, 2018: Bioorganic & Medicinal Chemistry Letters
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