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https://www.readbyqxmd.com/read/29044052/management-of-nasolacrimal-duct-obstruction-in-children-how-is-it-changing
#1
EDITORIAL
Ashok Kumar Grover
No abstract text is available yet for this article.
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29041772/randomized-apertures-high-resolution-imaging-in-far-field-erratum
#2
Xiaopeng Peng, Garreth J Ruane, Marco B Quadrelli, Grover A Swartzlander
We note a correction to Eq. (6) for [ Opt. Express25(15), 18296 (2017)].
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29033063/factor-analysis-of-symptom-profile-in-early-onset-and-late-onset-ocd
#3
Sandeep Grover, Siddharth Sarkar, Gourav Gupta, Natasha Kate, Abhishek Ghosh, Subho Chakrabarti, Ajit Avasthi
This study aimed to assess the factor structure of early and late onset OCD. Additionally, cluster analysis was conducted in the same sample to assess the applicability of the factors. 345 participants were assessed with Yale Brown Obsessive Compulsive Scale symptom checklist. Patients were classified as early onset (onset of symptoms at age ≤ 18 years) and late onset (onset at age > 18 years) OCD depending upon the age of onset of the symptoms. Factor analysis and cluster analysis of early-onset and late-onset OCD was conducted...
October 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29024731/the-y-technique-an-attempt-to-standardize-nail-dressing
#4
Karalikkattil T Ashique, Chander Grover
No abstract text is available yet for this article.
October 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29021126/healthydads-ca-what-do-men-want-in-a-website-designed-to-promote-emotional-wellness-and-healthy-behaviors-during-the-transition-to-parenthood
#5
Deborah Da Costa, Phyllis Zelkowitz, Nicole Letourneau, Andrew Howlett, Cindy-Lee Dennis, Brian Russell, Steven Grover, Ilka Lowensteyn, Peter Chan, Samir Khalifé
BACKGROUND: Up to 18% of men experience depression and/or anxiety during the transition to parenthood. Interventions designed specifically to promote the mental health of men during the transition to parenthood are scarce. Internet-delivered interventions may be acceptable and far-reaching in enhancing mental health, parenting knowledge, and healthy behaviors in expectant or new fathers. OBJECTIVE: To guide the development of Healthydads.ca, a website designed to enhance mental health and healthy behaviors in expectant fathers, a needs assessment was conducted to identify fathers' perspectives of barriers to seeking help for emotional wellness, informational needs, and factors affecting the decision to visit such a website...
October 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29017269/cancer-attributable-mortality-among-people-with-treated-human-immunodeficiency-virus-infection-in-north-america
#6
Eric A Engels, Elizabeth L Yanik, Willian Wheeler, M John Gill, Meredith S Shiels, Robert Dubrow, Keri N Althoff, Michael J Silverberg, John T Brooks, Mari M Kitahata, James J Goedert, Surbhi Grover, Angel M Mayor, Richard D Moore, Lesley S Park, Anita Rachlis, Keith Sigel, Timothy R Sterling, Jennifer E Thorne, Ruth M Pfeiffer
Background: Cancer remains an important cause of morbidity and mortality in people with human immunodeficiency virus (PWHIV) on effective antiretroviral therapy (ART). Estimates of cancer-attributable mortality can inform public health efforts. Methods: We evaluated 46956 PWHIV receiving ART in North American HIV cohorts (1995-2009). Using information on incident cancers and deaths, we calculated population-attributable fractions (PAFs), estimating the proportion of deaths due to cancer...
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28993120/coronary-lumen-volume-to-myocardial-mass-ratio-in-primary-microvascular-angina
#7
Rominder Grover, Jonathon A Leipsic, John Mooney, Shaw-Hua Kueh, Mickael Ohana, Bjarne L Nᴓrgaard, Ashkan Eftekhari, Jeroen J Bax, Darra T Murphy, Cameron J Hague, Michael A Seidman, Philipp Blanke, Tara Sedlak, Stephanie L Sellers
BACKGROUND: Microvascular angina (MVA) is an incompletely understood clinical entity. Computational analysis of coronary Computed Tomography Angiography (CTA) has shown an association between low coronary lumen volume to myocardial mass (V/M) ratio and lower Fractional Flow Reserve values, independent of plaque measures. We hypothesized that low V/M ratio may be present in patients with MVA. METHODS: A retrospective case-control analysis was performed using patients fulfilling guideline criteria for MVA with controls matched for age, gender, coronary risk factors and atherosclerotic plaque burden...
September 22, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28989700/toxicological-implications-of-mitochondrial-localization-of-cyp2e1
#8
Jessica H Hartman, Grover P Miller, Joel N Meyer
Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants, drugs, and other small molecules, often resulting in bioactivation to reactive metabolites. Therefore, it is unsurprising that it has been the subject of decades of research publications and reviews. However, while CYP2E1 has historically been studied in the endoplasmic reticulum (erCYP2E1), active CYP2E1 is also present in mitochondria (mtCYP2E1). Relatively few studies have specifically focused on mtCYP2E1, but there is growing interest in this form of the enzyme as a driver in toxicological mechanisms given its activity and location...
2017: Toxicology Research
https://www.readbyqxmd.com/read/28989133/gingival-crevicular-fluid-turnover-markers-in-premenopausal-vs-postmenopausal-women-receiving-orthodontic-treatment
#9
Anusha Bitra, B Jhansi Rani, Sanket S Agarkar, Anuj S Parihar, Gopinath P Vynath, Shekhar Grover
BACKGROUND: Orthodontic treatment is one of the commonly used dental treatments. Orthodontic forces act on the bone by modulating the biomolecules, chiefly the osteoprotegerin (OPG), osteopontin (OPN), receptor activator of nuclear factor kappa-B (RANK), and RANK ligand (RANKL) (OPG ligand). Hormonal changes are known to cause marked alteration in the levels of these biomolecules. Hence, we planned this study to evaluate the response of bone biomarkers in the gingival crevicular fluid (GCF) in postmenopausal women undergoing fixed orthodontic therapy...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28986147/fractional-flow-reserve-derived-from-coronary-computed-tomography-angiography-reclassification-rate-using-value-distal-to-lesion-compared-to-lowest-value
#10
Shaw Hua Kueh, John Mooney, Mickaël Ohana, Ung Kim, Philipp Blanke, Rominder Grover, Stephanie Sellers, Jennifer Ellis, Darra Murphy, Cameron Hague, Jeroen J Bax, Bjarne L Nørgaard, Mark Rabbat, Jonathon A Leipsic
INTRODUCTION: A standardised approach to the interpretation of FFRCT data is currently lacking. We evaluated the rate of reclassification of FFRCT positivity using the FFRCT value distal to an anatomical stenoses compared to the lowest FFRCT value. METHOD: Patients who underwent coronary CTA and FFRCT analysis were eligible. FFRCT value of ≤ 0.80 was considered positive. Positive FFRCT distal to stenosis was defined as those with a stenoses of ≥ 25% with an associated FFRCT value of ≤ 0...
September 21, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28985687/evaluating-the-swelling-erosion-and-compaction-properties-of-cellulose-ethers
#11
Muhammad U Ghori, Liam M Grover, Kofi Asare-Addo, Alan M Smith, Barbara R Conway
Swelling, erosion, deformation and consolidation properties can affect the performance of cellulose ethers, the most commonly used matrix former in hydrophilic sustained tablet formulations. The present study was designed to comparatively evaluate the swelling, erosion, compression, compaction and relaxation properties of the cellulose ethers in a comprehensive study using standardised conditions. The interrelationship between various compressional models and the inherent deformation and consolidation properties of the polymers on the derived swelling and erosion parameters are consolidated...
October 6, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28981210/proteome-and-structural-organization-of-the-knob-complex-on-the-surface-of-the-plasmodium-infected-red-blood-cell
#12
ShubaVarshini Alampalli, Manish Grover, Syama Chandran, Utpal Tatu, Pragyan Achary
PURPOSE: The cell membrane of the erythrocytes infected with the malaria parasite Plasmodium falciparum undergoes several changes during the course of parasite life cycle and forms protrusions known as 'knobs' on its surface during the mature trophozoite and schizont stages. The structural organization of knob components especially PfEMP1 on the iRBC surface is the main determinant for the cytoadhesive and rosetting capacity of the iRBC by binding to various host receptors as well as for the variable antigenicity, which is crucial for immunoevasion...
October 5, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28980723/role-of-pnca-gene-mutations-w68r-and-w68g-in-pyrazinamide-resistance
#13
Mansi Aggarwal, Aditi Singh, Sonam Grover, Bharati Pandey, Anchala Kumari, Abhinav Grover
Mycobacterium tuberculosis (Mtb) resistance towards anti-tuberculosis drugs is a widespread problem. Pyrazinamide (PZA) is a first line antitubercular drug that kills semi-dormant bacilli when converted into its activated form i.e. pyrazinoic acid (POA) by Pyrazinamidase (PZase) enzyme coded by pncA gene. In this study, we conducted several analyses on native and mutant structures (W68R, W68G) of PZase before and after docking with the PZA drug to explore the molecular mechanism behind PZA resistance caused due to pncA mutations...
October 5, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28980535/the-nail-as-an-investigative-tool-in-medicine-what-a-dermatologist-ought-to-know
#14
REVIEW
Chander Grover, Shikha Bansal
The nail is an important skin appendage, but not many dermatologists are aware of the importance it receives outside our specialty. This article focuses on the nail in non-dermatological contexts. The nail is a keratinized matrix capable of continuous growth with the ability to incorporate various compounds within its structure. Therefore it can be used to monitor long-term consumption of drugs. It is also an excellent source of germ-line DNA for genetic analyses. With an increased undrstanding of nail physiology, there is now a better understanding of its connection to various pathologies as well...
October 4, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28980266/mendelian-randomization
#15
Sandeep Grover, Fabiola Del Greco M, Catherine M Stein, Andreas Ziegler
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding. It utilizes one or more genetic polymorphisms as a proxy for the exposure variable of interest. Polymorphisms are randomly distributed in a population, they are static throughout an individual's lifetime, and may thus help in inferring directionality in exposure-outcome associations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28980063/evaluation-of-two-staged-fowler-stephens-laparoscopic-orchidopexy-fslo-for-intra-abdominal-testes-iat
#16
Deepak Bagga, Ashish Prasad, Shabnam Bhandari Grover, Nidhi Sugandhi, Narender Tekchandani, Samir Kant Acharya, Amat Samie
INTRODUCTION: The best operative intervention for intrabdominal testis (IAT) has not been standardized as yet. The question of whether to bring down an IAT with a single-staged vessel-intact laparoscopic orchidopexy (VILO) or a two-staged laparoscopic Fowler-Stephens orchidopexy (FSLO) is still undergoing debate, with both the procedures being popular. The present study has been designed to evaluate the factors predicting the success or failure of two-staged FSLO for (IAT). METHODS: 43 boys with 49 non-palpable testes underwent diagnostic laparoscopy out of which 35 underwent two-staged FSLO...
October 4, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28979869/nicolau-syndrome-following-intramatricial-triamcinolone-injection-for-nail-lichen-planus
#17
Chander Grover, Geetali Kharghoria, Deepashree Daulatabad, Sambit N Bhattacharya
Nicolau syndrome (Embolia cutis medicamentosa) is a rare complication following parenteral administration of a drug. It has been reported in association with intramuscular, subcutaneous, intravenous and intra-articular injections. However, Nicolau syndrome following intramatricial injection has not been described to the best of our knowledge. We report the case of an 18-year-old male who developed this complication following 7(th) session of intramatricial injection. The patient was started on broad spectrum antibiotic coverage, vasodilator therapy, analgesics, and daily dressing...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28975346/annals-story-slam-luther
#18
Samir C Grover
No abstract text is available yet for this article.
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28974747/annexin-enriched-osteoblast-derived-vesicles-act-as-an-extracellular-site-of-mineral-nucleation-within-developing-stem-cell-cultures
#19
O G Davies, S C Cox, R L Williams, D Tsaroucha, R M Dorrepaal, M P Lewis, L M Grover
The application of extracellular vesicles (EVs) as natural delivery vehicles capable of enhancing tissue regeneration could represent an exciting new phase in medicine. We sought to define the capacity of EVs derived from mineralising osteoblasts (MO-EVs) to induce mineralisation in mesenchymal stem cell (MSC) cultures and delineate the underlying biochemical mechanisms involved. Strikingly, we show that the addition of MO-EVs to MSC cultures significantly (P < 0.05) enhanced the expression of alkaline phosphatase, as well as the rate and volume of mineralisation beyond the current gold-standard, BMP-2...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28972371/enzymatic-generation-of-highly-anticoagulant-bovine-intestinal-heparin
#20
Li Fu, Kevin Li, Daisuke Mori, Makoto Hirakane, Lei Lin, Navdeep Grover, Payel Datta, Yanlei Yu, Jing Zhao, Fuming Zhang, Murat Yalcin, Shaker A Mousa, Jonathan S Dordick, Robert J Linhardt
Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1, -3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.
October 16, 2017: Journal of Medicinal Chemistry
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