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Jane E Girling, Samuel Cj Hawthorne, Jennifer L Marino, Abdul G Nur Azurah, Sonia R Grover, Yasmin L Jayasinghe
STUDY OBJECTIVE: No studies have specifically considered paternal understanding of menstruation. This study aimed to establish the degree of understanding of fathers of adolescent girls with menstrual symptoms relative to mothers. DESIGN AND SETTING: This is a cross-sectional survey-based study. Adolescent patients attending an outpatient gynaecology clinic for dysmenorrhoea and/or heavy menstrual bleeding (HMB) and their parents were invited to complete surveys...
April 12, 2018: Journal of Pediatric and Adolescent Gynecology
Bhanuramya Mangalampalli, Naresh Dumala, Paramjit Grover
Allium cepa bioassay had been used from decades for the assessment of toxicants and their harmful effects on environment as well as human health. Magnesium oxide (MgO) particles are being utilized in different fields. However, reports on the adverse effects of MgO nanoparticles on the environment and mankind are scarce. Hence, the toxicity of MgO particles is of concern because of their increased utilization. In the current study, A. cepa was used as an indicator to assess the toxicological efficiency of MgO nano- and microparticles (NPs and MPs) at a range of exposure concentrations (12...
April 2018: Journal of Environmental Sciences (China)
Jutta Keller, Gabrio Bassotti, John Clarke, Phil Dinning, Mark Fox, Madhusudan Grover, Per M Hellström, Meiyun Ke, Peter Layer, Carolina Malagelada, Henry P Parkman, S Mark Scott, Jan Tack, Magnus Simren, Hans Törnblom, Michael Camilleri
Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large proportion of the population worldwide, impair quality of life and cause considerable health-care costs. Assessment of gastrointestinal motility in these patients can serve to establish diagnosis and to guide therapy. Major advances in diagnostic techniques during the past 5-10 years have led to this update about indications for and selection and performance of currently available tests. As symptoms have poor concordance with gastrointestinal motor dysfunction, clinical motility testing is indicated in patients in whom there is no evidence of causative mucosal or structural diseases such as inflammatory or malignant disease...
April 6, 2018: Nature Reviews. Gastroenterology & Hepatology
Todd C Lee, Mohammed Kaouache, Steven A Grover
BACKGROUND: Evolocumab, a proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitor, has been shown to reduce low-density lipoprotein levels by up to 60%. Despite the absence of a reduction in overall or cardiovascular mortality in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, some believe that, with longer treatment, such a benefit might eventually be realized. Our aim was to estimate the potential mortality benefit over a patient's lifetime and the cost per year of life saved (YOLS) for an average Canadian with established coronary artery disease...
April 3, 2018: CMAJ Open
Surbhi Grover, Memory Bvochora-Nsingo, Alyssa Yeager, Sebathu Chiyapo, Rohini Bhatia, Emily MacDuffie, Priya Puri, Dawn Balang, Sarah Ratcliffe, Mohan Narasimhamurthy, Elliphine Gwangwava, Sylvia Tsietso, Mukendi K A Kayembe, Doreen Ramogola-Masire, Scott Dryden-Peterson, Umesh Mahantshetty, Akila N Viswanathan, Nicola M Zetola, Lilie L Lin
PURPOSE: To prospectively compare survival between human immunodeficiency virus (HIV)-infected versus HIV-uninfected cervical cancer patients who initiated curative chemoradiation therapy (CRT) in a limited-resource setting. METHODS AND MATERIALS: Women with locally advanced cervical cancer with or without HIV infection initiating radical CRT in Botswana were enrolled in a prospective, observational, cohort study from July 2013 through January 2015. RESULTS: Of 182 women treated for cervical cancer during the study period, 143 women initiating curative CRT were included in the study...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Gunvant Patil, Tri D Vuong, Sandip Kale, Babu Valliyodan, Rupesh Deshmukh, Chengsong Zhu, Xiaolei Wu, Yonghe Bai, Dennis Yungbluth, Fang Lu, Siva Kumpatla, J Grover Shannon, Rajeev K Varshney, Henry T Nguyen
The cultivated [Glycine max (L) Merr.] and wild [Glycine soja Siebold & Zucc.] soybean species comprise wide variation in seed composition traits. Compared to wild soybean, cultivated soybean contains low protein, high oil and high sucrose. In this study, an inter-specific population was derived from a cross between G. max (Williams 82) and G. soja (PI 483460B). This recombinant inbred line (RIL) population of 188 lines was sequenced at 0.3x depth. Based on 91,342 single nucleotide polymorphisms (SNPs), recombination events in RILs were defined, and a high-resolution bin map was developed (4,070 bins)...
April 4, 2018: Plant Biotechnology Journal
Anoop K Gupta, Swapnajeet Sahoo, Sandeep Grover
<b/> Narcolepsy is an uncommon sleep cycle disorder with a usual onset in adolescence, but it is often misdiagnosed and underdiagnosed. Rarely is the tetrad of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis seen in patients. The clinical characteristics of narcolepsy are often confused with many psychiatric and neurologic disorders. Lack of clinical awareness about narcolepsy leads to frequent prescriptions of antiepileptics and psychotropics, which can adversely affect the quality of life of children and adolescents...
July 2017: Innovations in Clinical Neuroscience
Davinder S Grover, Oluwatosin Smith, Ronald L Fellman, David G Godfrey, Aditi Gupta, Ildamaris Montes de Oca, William J Feuer
PURPOSE: Provide 24-month follow up on surgical success and safety of an ab interno circumferential 360-degree trabeculotomy. PATIENTS AND METHODS: Chart review of patients who underwent a GATT procedure by 4 of the authors (D.S.G., O.S., R.L.F., D.G.G.). The surgery was performed in adults with various open-angle glaucomas with pre-operative intraocular pressures (IOP) of ≥18▒mm Hg. RESULTS: 198 patients aged 24-89 years underwent the GATT procedure with at least 18 months follow-up...
April 2, 2018: Journal of Glaucoma
Xiaoying Zhu, Michael J Grover
Cervicogenic dizziness is a sensation of disequilibrium caused by abnormal afferent activity from the neck. Its diagnosis and treatment are challenging. In a case of cervicogenic dizziness, we performed diagnostic upper cervical medial branch nerve blocks with near complete symptomatic relief for around 20 hours. Radiofrequency ablation of these nerves resulted in near complete relief for 7 months. Subsequent repeat ablations provided the same relief lasting for 6-10 months. This case suggests that upper cervical medial branch block can serve as a diagnostic test for cervicogenic dizziness, and radiofrequency ablation of these nerves might be an effective treatment...
March 15, 2018: A&A practice
Claudia Sellmaier, Pauline Jivanjee, Eileen M Brennan, Leigh Grover
No abstract text is available yet for this article.
March 29, 2018: Journal of Behavioral Health Services & Research
Udai S Sibia, Jennifer Grover, Justin J Turcotte, Michelle L Seanger, Kimberly A England, Jennifer L King, Paul J King
PURPOSE: We describe a process for studying and improving baseline postanesthesia care unit (PACU)-to-floor transfer times after total joint replacements. DESIGN: Quality improvement project using lean methodology. METHODS: Phase I of the investigational process involved collection of baseline data. Phase II involved developing targeted solutions to improve throughput. Phase III involved measured project sustainability. FINDINGS: Phase I investigations revealed that patients spent an additional 62 minutes waiting in the PACU after being designated ready for transfer...
April 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
I Brian Greenwell, Ashley D Staton, Michael J Lee, Jeffrey M Switchenko, Debra F Saxe, Joseph J Maly, Kristie A Blum, Natalie S Grover, Stephanie P Mathews, Max J Gordon, Alexey V Danilov, Narendranath Epperla, Timothy S Fenske, Mehdi Hamadani, Steven I Park, Christopher R Flowers, Jonathon B Cohen
BACKGROUND: Risk stratification of newly diagnosed patients with mantle cell lymphoma (MCL) primarily is based on the MCL International Prognostic Index (MIPI) and Ki-67 proliferative index. Single-center studies have reported inferior outcomes in patients with a complex karyotype (CK), but this remains an area of controversy. METHODS: The authors retrospectively reviewed 483 patients from 5 academic centers in the United States and described the effect of a CK on survival outcomes in individuals with MCL...
March 26, 2018: Cancer
Ashlee Kimball, Sanjana Patil, Bogda Koczwara, Karthigesh Sree Raman, Rebecca Perry, Suchi Grover, Joseph Selvanayagam
BACKGROUND: Anthracycline (A) and trastuzumab (T) chemotherapy have well-recognized cardiac toxicity, potentially leading to significant morbidity and mortality. Our previous work in 46 prospectively enrolled breast cancer patients showed early left ventricular (LV) and right ventricular (RV) function decline at 1 and 3 months, but only persistent RV dysfunction at 12 months which correlated with myocardial oedema observed early (1 and 3 months) after administration of chemotherapy regimes...
March 8, 2018: International Journal of Cardiology
Anchala Kumari, Rinky Rajput, Nidhi Shrivastava, Pallavi Somvanshi, Abhinav Grover
Alzheimer's disease is a severe brain illness that causes vast numbers of nerve cells in the brain to die, driven by the production and deposition of amyloid beta (Aβ) peptides. Intrinsically disordered proteins (IDPs) generally lack stable structures and are abundant in nature. Aβ peptide is a well-known IDP with a wide range of oligomeric forms. Dysfunctions in Aβ lead to oligomerization, formation of fibrils, and neurodegenerative disorders or other forms of dementia. In this study, we used replica exchange molecular dynamics (REMD) to elucidate the roles of different osmolytes, particularly urea and trimethylamine N-oxide (TMAO), to study shifts in IDP populations...
March 20, 2018: International Journal of Biochemistry & Cell Biology
Toshihiro Sato, Fakher F Assaad, Tarun Grover
The absence of the negative sign problem in quantum Monte Carlo simulations of spin and fermion systems has different origins. World-line based algorithms for spins require positivity of matrix elements whereas auxiliary field approaches for fermions depend on symmetries such as particle-hole symmetry. For negative-sign-free spin and fermionic systems, we show that one can formulate a negative-sign-free auxiliary field quantum Monte Carlo algorithm that allows Kondo coupling of fermions with the spins. Using this general approach, we study a half-filled Kondo lattice model on the honeycomb lattice with geometric frustration...
March 9, 2018: Physical Review Letters
Jeffrey W Grover, Timmy Kendall, Abdul Baten, Diane Burgess, Michael Freeling, Graham J King, Rebecca A Mosher
Small RNAs trigger repressive DNA methylation at thousands of transposable elements in a process called RNA-directed DNA Methylation (RdDM). The molecular mechanism of RdDM is well-characterized in Arabidopsis, yet the biological function remains unclear, since loss of RdDM in Arabidopsis causes no overt defects, even after generations of inbreeding. 24 nucleotide Pol IV-dependent siRNAs, the hallmark of RdDM, are abundant in flowers and developing seeds, indicating that RdDM might be important during reproduction...
March 23, 2018: Plant Journal: for Cell and Molecular Biology
Alexandra Iordachescu, Philippa Hulley, Liam M Grover
Nanovesicles, exosomes and other membrane bound particles excreted by cells are currently gaining research attention since they have been shown to play a significant role in many biologically related processes. Vesicles are now thought to mediate cellular communication, transmission of some diseases and pathologically mediated calcification. Matrix vesicles have long been proposed to be central to the controlled mineralisation of bone. They remain relatively poorly studied, however, since they are challenging to extract from biological media...
February 13, 2018: RSC Advances
Suzanne V Arnold, Sean M O'Brien, Sreekanth Vemulapalli, David J Cohen, Amanda Stebbins, J Matthew Brennan, David M Shahian, Fred L Grover, David R Holmes, Vinod H Thourani, Eric D Peterson, Fred H Edwards
OBJECTIVES: The aim of this study was to develop and validate a risk adjustment model for 30-day mortality after transcatheter aortic valve replacement (TAVR) that accounted for both standard clinical factors and pre-procedural health status and frailty. BACKGROUND: Assessment of risk for TAVR is important both for patient selection and provider comparisons. Prior efforts for risk adjustment have focused on in-hospital mortality, which is easily obtainable but can be biased because of early discharge of ill patients...
March 26, 2018: JACC. Cardiovascular Interventions
Brooke L Namboodri, Tony Rosen, Joseph A Dayaa, Jason J Bischof, Nadeem Ramadan, Mehul D Patel, Joseph Grover, Jane H Brice, Timothy F Platts-Mills
OBJECTIVES: To describe statewide emergency medical service (EMS) protocols relating to identification, management, and reporting of elder abuse in the prehospital setting. DESIGN: Cross-sectional analysis. SETTING: Statewide EMS protocols in the United States. PARTICIPANTS: Publicly available statewide EMS protocols identified from published literature,, and each state's public health website...
March 22, 2018: Journal of the American Geriatrics Society
Steven P Grover, Wolfgang Bergmeier, Nigel Mackman
No abstract text is available yet for this article.
April 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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