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https://www.readbyqxmd.com/read/28102002/pseudoherpetic-transient-acantholytic-dermatosis-grover-disease-case-series-and-review-of-the-literature
#1
Kiran Motaparthi
Three cases of pseudoherpetic transient acantholytic dermatosis (Grover disease) are presented, followed by a brief review of prior reports. All three patients were above the age of 60 and presented with a pruritic eruption composed of papules with or without vesicles distributed on the trunk. For all three patients, the clinical differential diagnosis included drug eruption but did not include Grover disease; in one patient, the clinical impression included herpesvirus infection. Similar histologic and immunohistochemical findings were demonstrated in all three cases...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28090287/transcription-factors-transcriptional-coregulators-and-epigenetic-modulation-in-the-control-of-pulmonary-vascular-cell-phenotype-therapeutic-implications-for-pulmonary-hypertension-2015-grover-conference-series
#2
REVIEW
Soni S Pullamsetti, Frédéric Perros, Prakash Chelladurai, Jason Yuan, Kurt Stenmark
Pulmonary hypertension (PH) is a complex and multifactorial disease involving genetic, epigenetic, and environmental factors. Numerous stimuli and pathological conditions facilitate severe vascular remodeling in PH by activation of a complex cascade of signaling pathways involving vascular cell proliferation, differentiation, and inflammation. Multiple signaling cascades modulate the activity of certain sequence-specific DNA-binding transcription factors (TFs) and coregulators that are critical for the transcriptional regulation of gene expression that facilitates PH-associated vascular cell phenotypes, as demonstrated by several studies summarized in this review...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28090286/novel-methods-in-pulmonary-hypertension-phenotyping-in-the-age-of-precision-medicine-2015-grover-conference-series
#3
REVIEW
Jarrod W Barnes, Adriano R Tonelli, Gustavo A Heresi, Jennie E Newman, Noël E Mellor, David E Grove, Raed A Dweik
Among pulmonary vascular diseases, pulmonary hypertension (PH) is the best studied and has been the focus of our work. The current classification of PH is based on a relatively simple combination of patient characteristics and hemodynamics. This leads to inherent limitations, including the inability to customize treatment and the lack of clarity from a more granular identification based on individual patient phenotypes. Accurate phenotyping of PH can be used in the clinic to select therapies and determine prognosis and in research to increase the homogeneity of study cohorts...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28090285/pulmonary-vascular-and-ventricular-dysfunction-in-the-susceptible-patient-2015-grover-conference-series
#4
REVIEW
Bradley A Maron, Roberto F Machado, Larissa Shimoda
Pulmonary blood vessel structure and tone are maintained by a complex interplay between endogenous vasoactive factors and oxygen-sensing intermediaries. Under physiological conditions, these signaling networks function as an adaptive interface between the pulmonary circulation and environmental or acquired perturbations to preserve oxygenation and maintain systemic delivery of oxygen-rich hemoglobin. Chronic exposure to hypoxia, however, triggers a range of pathogenetic mechanisms that include hypoxia-inducible factor 1α (HIF-1α)-dependent upregulation of the vasoconstrictor peptide endothelin 1 in pulmonary endothelial cells...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28087034/dermoscopy-of-grover-disease
#5
Luciana de Abreu, Natália Gomes Guimarães Cordeiro, Alice Mota Buçard, Danielle Carvalho Quintella, Giuseppe Argenziano
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28078207/health-care-needs-of-remitted-patients-with-bipolar-disorder-a-comparison-with-schizophrenia
#6
Rajarshi Neogi, Subho Chakrabarti, Sandeep Grover
AIM: To investigate health-care needs and their correlates among patients with remitted bipolar disorder (BD) compared to patients with remitted schizophrenia. METHODS: Outpatients with BD (n = 150) and schizophrenia (n = 75) meeting clearly defined remission criteria were included in the study along with their relatives. Diagnostic ascertainment was carried out using the Mini International Neuropsychiatric Interview. Demographic and clinical details were recorded using structured formats...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28077764/antimicrobial-peptide-coatings-for-hydroxyapatite-electrostatic-and-covalent-attachment-of-antimicrobial-peptides-to-surfaces
#7
Leigh Townsend, Richard L Williams, Olachi Anuforom, Matthew R Berwick, Fenella Halstead, Erik Hughes, Artemis Stamboulis, Beryl Oppenheim, Julie Gough, Liam Grover, Robert A H Scott, Mark Webber, Anna F A Peacock, Antonio Belli, Ann Logan, Felicity de Cogan
The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material-tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs...
January 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28076262/physician-cost-consciousness-and-use-of-low-value-clinical-services
#8
Michael Grover, Neena Abraham, Yu-Hui Chang, Jon Tilburt
PURPOSE: Choosing Wisely(TM) engaged medical specialties, creating "top 5 lists" of low-value services. We describe primary care physicians' (PCPs') self-reported use of these services and perceived barriers to guideline adherence. We quantify physician cost consciousness and determine associations with use. METHODS: PCP attendees of a continuing medical education conference completed a survey. For each Family Medicine Choosing Wisely behavior, participants reported clinical adherence...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28074021/the-assimilation-of-diazotroph-derived-nitrogen-by-scleractinian-corals-depends-on-their-metabolic-status
#9
Vanessa N Bednarz, Renaud Grover, Jean-François Maguer, Maoz Fine, Christine Ferrier-Pagès
: Tropical corals are associated with a diverse community of dinitrogen (N2)-fixing prokaryotes (diazotrophs) providing the coral an additional source of bioavailable nitrogen (N) in oligotrophic waters. The overall activity of these diazotrophs changes depending on the current environmental conditions, but to what extent it affects the assimilation of diazotroph-derived N (DDN) by corals is still unknown. Here, in a series of (15)N2 tracer experiments, we directly quantified DDN assimilation by scleractinian corals from the Red Sea exposed to different environmental conditions...
January 10, 2017: MBio
https://www.readbyqxmd.com/read/28071975/dynamics-of-fluoroquinolones-induced-resistance-in-dna-gyrase-of-mycobacterium-tuberculosis
#10
Bharati Pandey, Sonam Grover, Chetna Tyagi, Sukriti Goyal, Salma Jamal, Aditi Singh, Jagdeep Kaur, Abhinav Grover
DNA gyrase is a validated target of fluoroquinolones which are key components of multidrug resistance (MDR) TB treatment. Most frequent occurring mutations associated with high level of resistance to fluoroquinolone in clinical isolates of TB patients are A90V, D94G and A90V-D94G (double mutant), present in the larger subunit of DNA Gyrase. In order to explicate the molecular mechanism of drug resistance corresponding to these mutations, molecular dynamics and mechanics approach was applied. Structure based molecular docking of complex comprised of DNA bound with Gyrase A (large subunit) and Gyrase C (small subunit) with moxifloxacin revealed high binding affinity to wild type with considerably high Glide XP docking score of -7...
January 10, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28069350/prevalence-risk-factors-and-outcomes-of-irritable-bowel-syndrome-after-infectious-enteritis-a-systematic-review-and-meta-analysis
#11
Fabiane Klem, Akhilesh Wadhwa, Larry Prokop, Wendy Sundt, Gianrico Farrugia, Michael Camilleri, Siddharth Singh, Madhusudan Grover
BACKGROUND & AIMS: Foodborne illness affects 15% of the United States population each year and is a risk factor for irritable bowel syndrome (IBS). We evaluated risk of, risk factors for, and outcomes of IBS after infectious enteritis METHODS: We performed a systematic review of electronic databases from 1994 through August 31, 2015 to identify cohort studies of the prevalence of IBS 3 months or more after infectious enteritis. We used random effects meta-analysis to calculate the summary point prevalence of IBS after infectious enteritis, as well as relative risk (compared to individuals without infectious enteritis) and host- and enteritis-related risk factors...
January 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28067396/edge-effect-of-strained-bilayer-nanofilms-for-tunable-multistability-and-actuation
#12
N Hu, X Han, S Huang, H M Grover, X Yu, L N Zhang, I Trase, J X J Zhang, L Zhang, L X Dong, Z Chen
We employed both theoretical and computational models supported by experiments to study the multistable behavior of an edge-effect driven Si/Cr micro-claw. Our study showed that individual micro-claws demonstrate either monostability or bistability as the magnitude of the edge effect is varied.
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28066953/diabetic-and-idiopathic-gastroparesis-is-associated-with-loss-of-cd206-positive-macrophages-in-the-gastric-antrum
#13
M Grover, C E Bernard, P J Pasricha, H P Parkman, S J Gibbons, J Tonascia, K L Koch, R W McCallum, I Sarosiek, W L Hasler, L A B Nguyen, T L Abell, W J Snape, M L Kendrick, T A Kellogg, T J McKenzie, F A Hamilton, G Farrugia
BACKGROUND: Animal studies have increasingly highlighted the role of macrophages in the development of delayed gastric emptying. However, their role in the pathophysiology of human gastroparesis is unclear. Our aim was to determine changes in macrophages and other cell types in the gastric antrum muscularis propria of patients with diabetic and idiopathic gastroparesis. METHODS: Full thickness gastric antrum biopsies were obtained from patients enrolled in the Gastroparesis Clinical Research Consortium (11 diabetic, 6 idiopathic) and 5 controls...
January 9, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28066016/thrombocytopenia-associated-with-olanzapine-a-case-report-and-review-of-literature
#14
Swapnajeet Sahoo, Himanshu Singla, M Spoorty, Pankaj Malhotra, Sandeep Grover
There is limited literature on olanzapine-associated thrombocytopenia. In this report, we present a case of a 32-year-old female, suffering from persistent delusional disorder who had thrombocytopenia (46,000/mm(3)) with the use of olanzapine 25 mg/day, 6 weeks after starting medication. Blood film did not reveal any evidence of any dysplastic cells, disturbance in the count of other cell lines, and autoimmune workup including antinuclear antibodies and anti-neutrophil cytoplasmic antibodies were found to be negative...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28066007/stigma-and-its-correlates-in-patients-with-schizophrenia-attending-a-general-hospital-psychiatric-unit
#15
Aakanksha Singh, Surendra K Mattoo, Sandeep Grover
BACKGROUND: Very few studies from India have studied stigma experienced by patients with schizophrenia. AIM OF THE STUDY: To study stigma in patients with schizophrenia (in the form of internalized stigma, perceived stigma and social-participation-restriction stigma) and its relationship with specified demographic and clinical variables (demographic variables, clinical profile, level of psychopathology, knowledge about illness, and insight). MATERIALS AND METHODS: Selected by purposive random sampling, 100 patients with schizophrenia in remission were evaluated on internalized stigma of mental illness scale (ISMIS), explanatory model interview catalog stigma scale, participation scale (P-scale), positive and negative syndrome scale for schizophrenia, global assessment of functioning scale, scale to assess unawareness of mental disorder, and knowledge of mental illness scale...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28064176/root-xylem-plasticity-to-improve-water-use-and-yield-in-water-stressed-soybean
#16
Silvas J Prince, Mackensie Murphy, Raymond N Mutava, Lorellin A Durnell, Babu Valliyodan, J Grover Shannon, Henry T Nguyen
We tested the hypothesis that increasing the number of metaxylem vessels would enhance the efficiency of water uptake in soybean (Glycine max) and decrease the yield gap in water-limited environments. A panel of 41 soybean accessions was evaluated in greenhouse, rainout shelter, and rain-fed field environments. The metaxylem number influenced the internal capture of CO2 and improved stomatal conductance, enhancing water uptake/use in soybeans exposed to stress during the reproductive stage. We determined that other root anatomical features, such as cortex cell area and the percentage of stele that comprised cortical cells, also affected seed yield under similar growth parameters...
January 7, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28062755/evolutionary-conservation-and-divergence-of-gene-coexpression-networks-in-gossypium-cotton-seeds
#17
Guanjing Hu, Ran Hovav, Corrinne E Grover, Adi Faigenboim-Doron, Noa Kadmon, Justin T Page, Joshua A Udall, Jonathan F Wendel
The cotton genus (Gossypium) provides a superior system for the study of diversification, genome evolution, polyploidization, and human-mediated selection. To gain insight into phenotypic diversification in cotton seeds, we conducted coexpression network analysis of developing seeds from diploid and allopolyploid cotton species and explored network properties. Key network modules and functional associations were identified related to seed oil content and seed weight. We compared species-specific networks to reveal topological changes, including rewired edges and differentially coexpressed genes, associated with speciation, polyploidy, and cotton domestication...
January 6, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28050999/retaining-health-workforce-in-rural-and-underserved-areas-of-india-what-works-and-what-doesn-t-a-critical-interpretative-synthesis
#18
REVIEW
Sonu Goel, Federica Angeli, Nidhi Bhatnagar, Neetu Singla, Manoj Grover, Hans Maarse
BACKGROUND: Human resource for health is critical in quality healthcare delivery. India, with a large rural population (68.8%), needs to urgently bridge the gaps in health workforce deployment between urban and rural areas. METHODS: We did a critical interpretative synthesis of the existing literature by using a predefined selection criteria to assess relevant manuscripts to identify the reasons for retaining the health workforce in rural and underserved areas. We discuss different strategies for retention of health workforce in rural areas on the basis of four major retention interventions, viz...
July 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28050526/non-surgical-management-of-teeth-with-wide-open-apices-and-large-periapical-lesions-a-conservative-reality
#19
Sarang Sharma, Shibani Grover, Pooja Dudeja, Vivek Sharma, Deepak Passi
No abstract text is available yet for this article.
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050079/gemella-sanguinis-a-rare-cause-of-native-valve-endocarditis-in-a-child
#20
Mugunthan M, Sharad Bhalla, Vishal Shete, Naveen Grover
No abstract text is available yet for this article.
December 2016: Medical Journal, Armed Forces India
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