Mark V Savitskii, Natalia E Moskaleva, Alex Brito, Pavel A Markin, Nailya A Zigangirova, Anna V Soloveva, Anna B Sheremet, Natalia E Bondareva, Nadezhda L Lubenec, Franco Tagliaro, Vadim V Tarasov, Kristina A Tatzhikova, Svetlana A Appolonova
Growing antimicrobial resistance has accelerated the development of anti-virulence drugs to suppress bacterial toxicity without affecting cell viability. Fluorothiazinon (FT), an anti-virulence, type three secretion system and flagella motility inhibitor which has shown promise to suppress drug-resistant pathogens having the potential to enhance the efficacy of commonly prescribed antibiotics when used in combination. In this study we characterized the pharmacokinetics, tissue distribution, bioavailability and excretion of FT in rats and rabbits...
March 15, 2024: Journal of Antibiotics