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https://www.readbyqxmd.com/read/29304227/combining-environmental-investigation-and-a-dual-analytical-strategy-to-isolate-the-legionella-longbeachae-strain-linked-to-two-occupational-cases-of-legionellosis
#1
Genevieve Marchand, Judith Lord, Carole Pépin, Nancy Lacombe
Legionella has a global distribution, mainly in aquatic and man-made environments. Under the right conditions, this bacterium is a notorious human pathogen responsible for severe pulmonary illnesses. Legionellosis outbreaks are reported around the world, and exposure to water droplet aerosols containing Legionella pneumophila is usually the mechanism of its transmission. Even if L. pneumophila causes most outbreaks, Legionella longbeachae also accounts for some cases. Unlike most other Legionella strains, L...
January 3, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29203712/heat-shock-protein-90-its-inhibition-and-function
#2
REVIEW
Abbey D Zuehlke, Michael A Moses, Len Neckers
The molecular chaperone heat shock protein 90 (Hsp90) facilitates metastable protein maturation, stabilization of aggregation-prone proteins, quality control of misfolded proteins and assists in keeping proteins in activation-competent conformations. Proteins that rely on Hsp90 for function are delivered to Hsp90 utilizing a co-chaperone-assisted cycle. Co-chaperones play a role in client transfer to Hsp90, Hsp90 ATPase regulation and stabilization of various Hsp90 conformational states. Many of the proteins chaperoned by Hsp90 (Hsp90 clients) are essential for the progression of various diseases, including cancer, Alzheimer's disease and other neurodegenerative diseases, as well as viral and bacterial infections...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29186670/changes-in-extreme-events-and-the-potential-impacts-on-human-health
#3
Jesse E Bell, Claudia Langford Brown, Kathryn Conlon, Stephanie Herring, Kenneth E Kunkel, Jay Lawrimore, George Luber, Carl Schreck, Adam Smith, Christopher Uejio
Extreme weather and climate-related events affect human health by causing death, injury, and illness, as well as having large socioeconomic impacts. Climate change has caused changes in extreme event frequency, intensity and geographic distribution, and will continue to be a driver for change in the future. Some of these events include heat waves, droughts, wildfires, dust storms, flooding rains, coastal flooding, storm surge, and hurricanes. The pathways connecting extreme events to health outcomes and economic losses can be diverse and complex...
November 29, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29183634/group-6-modalities-and-frequency-of-monitoring-of-patients-with-adrenal-insufficiency-patient-education
#4
Laurence Guignat, Emmanuelle Proust-Lemoine, Yves Reznik, Delphine Zenaty
Patients with adrenal insufficiency require regular, specialised monitoring in order to optimise their replacement therapy, to detect signs of under- and over-dosage, and to examine for possible associated disorders (auto-immune disorders in the case of auto-immune primary adrenal insufficiency either isolated or as part of auto-immune polyendocrinopathy syndrome type 1; illnesses with underlying monogenic causes). The transition period between adolescence and adulthood represents an added risk of a breakdown in monitoring which requires particular attention from medical teams and coordination between adult and pediatric medical teams...
November 25, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29165429/air-temperature-exposure-and-agricultural-occupational-injuries-in-the-autonomous-province-of-trento-2000-2013-north-eastern-italy
#5
Matteo Riccò
OBJECTIVES: The aim of this study was to evaluate the relationship between high air temperatures and occupational injuries (OIs) occurred during the summer seasons 2000-2013 in agricultural workers from the Autonomous Province of Trento (APT), North-Eastern Italy. MATERIAL AND METHODS: Data about OIs for the APT from 2000 to 2013 occurring during the warm season (N = 7325) was provided by the National Institute of Insurance for Occupational Illness and Injury. Daily average and daily maximum temperatures values for the specific geographical site of events were retrieved...
November 20, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29157839/lifestyles-guide-and-glaucoma-i-sports-and-activities
#6
J Moreno-Montañés, A Antón-López, S Duch-Tuesta, P Corsino Fernández-Vila, J García-Feijoó, E Millá-Griñó, F J Muñoz-Negrete, L Pablo-Júlvez, I Rodríguez-Agirretxe, J L Urcelay-Segura, F Ussa-Herrera, M P Villegas-Pérez
PURPOSES: The increase in quality and life expectancy, often leads to many patients asking the glaucoma specialist whether some sports, activities or hobbies would affect their illness. The aim of this article is to establish guidelines for patients, based on the scientific evidence of published papers. METHODS: Review of all published articles on glaucoma and sports or other activities. The papers were classified according to the level of scientific evidence based on the Oxford Centre for Evidence-Based Medicine classification...
November 17, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29147922/the-effect-of-head-to-head-competition-on-behavioural-thermoregulation-thermophysiological-strain-and-performance-during-exercise-in-the-heat
#7
Jo Corbett, Danny K White, Martin J Barwood, Christopher R D Wagstaff, Michael J Tipton, Terry McMorris, Joseph T Costello
BACKGROUND: It has been suggested that pacing is a thermoregulatory behaviour. We investigated the effect of competition on pacing, performance and thermophysiological strain during exercise in the heat and the psychological factors mediating competition effects. METHOD: Eighteen males (maximum oxygen uptake [V O 2max] 3.69 [0.44] L min(-1)) undertook a preliminary 20-km cool (wet-bulb globe temperature [WBGT] 12 °C) cycling time trial (TT) and three experimental 20-km trials (balanced order): (i) cool TT (CoolSolo); (ii) hot (WBGT 26 °C) TT (HotSolo); (iii) hot head-to-head competition (HotH2H)...
November 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29144831/attention-deficit-hyperactivity-disorder-unique-considerations-in-athletes
#8
Chaney G Stewman, Catherine Liebman, Laura Fink, Brad Sandella
CONTEXT: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition in the general population, with evidence suggesting that it may be more common among athletes. EVIDENCE ACQUISITION: Literature searches were performed on PubMed, MEDLINE, and Cochrane databases for the years 2000 to 2016 utilizing the following key search terms: ADHD, ADD, guidelines, diagnosis, athlete, sports, treatment, pharmacotherapy, stimulants, risk, cardiovascular effects, concussion, and traumatic brain injury (TBI)...
November 1, 2017: Sports Health
https://www.readbyqxmd.com/read/29122180/associations-between-heat-exposure-vigilance-and-balance-performance-in-summer-tree-fruit-harvesters
#9
June T Spector, Jennifer Krenz, Miriam Calkins, Dawn Ryan, Jose Carmona, Mengjie Pan, Anna Zemke, Paul D Sampson
BACKGROUND: We sought to evaluate potential mediators of the relationship between heat exposure and traumatic injuries in outdoor agricultural workers. METHODS: Linear mixed models were used to estimate associations between maximum work-shift Wet Bulb Globe Temperature (WBGTmax) and post-shift vigilance (reaction time) and postural sway (total path length) in a cross-sectional sample of 46 Washington State tree fruit harvesters in August-September 2015. RESULTS: The mean (SD) WBGTmax was 27...
February 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29104933/heat-resistance-mediated-by-plm58-plasmid-borne-clpl-in-listeria-monocytogenes
#10
Anna Pöntinen, Mariella Aalto-Araneda, Miia Lindström, Hannu Korkeala
Listeria monocytogenes is one of the most heat-resistant non-spore-forming food-borne pathogens and poses a notable risk to food safety, particularly when mild heat treatments are used in food processing and preparation. While general heat stress properties and response mechanisms of L. monocytogenes have been described, accessory mechanisms providing particular L. monocytogenes strains with the advantage of enhanced heat resistance are unknown. Here, we report plasmid-mediated heat resistance of L. monocytogenes for the first time...
November 2017: MSphere
https://www.readbyqxmd.com/read/29096566/perivascular-extension-of-microwave-ablation-zone-demonstrated-using-an-ex-vivo-porcine-perfusion-liver-model
#11
Saurabh Singh, Pulathis Nilantha Siriwardana, Edward William Johnston, Jennifer Watkins, Steve Bandula, Rowland Illing, Brian Ritchie Davidson
Microwave ablation (MWA) has been proposed to suffer less from the heat sink effect compared to radiofrequency ablation but has been reported to cause extension of the ablation zone along intrahepatic vessels in clinical practice. To study this effect in detail, eight fresh porcine livers were perfused in an ex-vivo organ perfusion system. Livers were perfused with oxygenated, O-positive human blood at 37°C. Perfusion was discontinued immediately before ablation in the non-perfused group (n = 4) whilst in the perfused group (n = 4) perfusion was maintained during MWA (140W X 2min)...
November 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29090983/assessment-of-occupational-exposure-to-heat-stress-and-solar-ultraviolet-radiation-among-groundskeepers-in-an-eastern-north-carolina-university-setting
#12
Nicole Beck, Jo Anne G Balanay, Terri Johnson
Groundskeepers spend most of the year working outdoors, exposing them to heat and solar ultraviolet (UV) radiation and increasing their risk to related adverse health effects. Various studies on heat and UV exposures in different occupations have been published, but those on groundskeepers are rare. The purpose of this study was to assess the exposure to heat stress and solar UV radiation among groundskeepers in an eastern North Carolina university setting. Wet bulb globe temperature (WBGT) index using a heat stress monitor and UV effective irradiance (UVeff) index using a digital UV meter were recorded in various work areas 3 times a day (morning, noon, afternoon) and during 3 seasons (spring, summer, fall)...
November 1, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29084063/central-vertigo
#13
Jeong-Yoon Choi, Seung-Han Lee, Ji-Soo Kim
PURPOSE OF REVIEW: This review considers recent advances in central vertigo in terms of clinical and laboratory features and pathophysiology. RECENT FINDINGS: Strokes presenting dizziness-vertigo are more likely to be associated with a misdiagnosis in the emergency setting. The risk of future strokes after discharge is higher in patients diagnosed with peripheral vertigo than in control patients. Strokes and transient ischemic attacks account for one-quarter of acute transient vestibular syndrome...
February 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29075863/copeptin-reflects-physiological-strain-during-thermal-stress
#14
Michael John Stacey, Simon K Delves, Sophie E Britland, Adrian J Allsopp, Stephen J Brett, Joanne L Fallowfield, David R Woods
PURPOSE: To prevent heat-related illnesses, guidelines recommend limiting core body temperature (T c) ≤ 38 °C during thermal stress. Copeptin, a surrogate for arginine vasopressin secretion, could provide useful information about fluid balance, thermal strain and health risks. It was hypothesised that plasma copeptin would rise with dehydration from occupational heat stress, concurrent with sympathoadrenal activation and reduced glomerular filtration, and that these changes would reflect T c responses...
October 27, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29074022/a-field-study-of-the-effectiveness-and-practicality-of-a-novel-hybrid-personal-cooling-vest-worn-during-rest-in-hong-kong-construction-industry
#15
Albert P C Chan, Ying Zhang, Faming Wang, Francis F K Wong, Daniel W M Chan
A novel hybrid cooling vest (HCV) incorporated with phase change materials (PCMs) and ventilation fans has been developed for construction workers in Hong Kong to attenuate heat stress and prevent heat-related illnesses, and its effectiveness and practicality have been validated in this study. A total of 140 wear trials involving of 140 workers were conducted in Hong Kong construction sites during the summer time. Each wear trial involves a two-day wear test, of which one day workers wore the HCV (denoted as VEST) during resting, and another day they wore traditional workwear (denoted as CON)...
December 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29066054/the-validity-of-the-heat-tolerance-test-in-prediction-of-recurrent-exertional-heat-illness-events
#16
Haggai Schermann, Yuval Heled, Chen Fleischmann, Itay Ketko, Nathan Schiffmann, Yoram Epstein, Ran Yanovich
OBJECTIVES: Heat-tolerance-testing (HTT) protocol is used as a screening test for secondary prevention of exertional heat illness (EHI) in the military. Subjects whose test results are positive (heat-intolerant, HI) are presumed to be at higher risk of repeated EHI events than heat-tolerant subjects (HT) and are therefore prevented from return to combat duty, but may return to unsupervised recreational activity. Our aim was to determine, whether HTT results predict the risk of repeated episodes of exertional heat illness (EHI)...
October 12, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29063376/recurrent-heat-shock-impairs-the-proliferation-and-differentiation-of-c2c12-myoblasts
#17
Daniel J Bolus, Gobinath Shanmugam, Madhusudhanan Narasimhan, Namakkal S Rajasekaran
Heat-related illness and injury are becoming a growing safety concern for the farmers, construction workers, miners, firefighters, manufacturing workers, and other outdoor workforces who are exposed to heat stress in their routine lives. A primary response by a cell to an acute heat shock (HS) exposure is the induction of heat-shock proteins (HSPs), which chaperone and facilitate cellular protein folding and remodeling processes. While acute HS is well studied, the effect of repeated bouts of hyperthermia and the sustained production of HSPs in the myoblast-myotube model system of C2C12 cells are poorly characterized...
October 24, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29057127/heat-stroke-a-medical-emergency-appearing-in-new-regions
#18
Sofie Søndergaard Mørch, Johnny Dohn Holmgren Andersen, Morten Heiberg Bestle
Heat stroke is an acute, life-threatening emergency characterized clinically by elevated body temperature and central nervous system dysfunction. Early recognition and treatment including aggressive cooling and management of life-threatening systemic complications are essential to reduce morbidity and mortality. This case report describes two Danish patients diagnosed with heat stroke syndrome during a heat wave in the summer of 2014. Both patients were morbidly obese and had several predisposing illnesses...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29036718/glutamatergic-response-to-heat-pain-stress-in-schizophrenia
#19
Joshua Chiappelli, Qiaoyun Shi, Sarah Andrea Wijtenburg, Raimi Quiton, Krista Wisner, Frank Gaston, Priyadurga Kodi, Christopher Gaudiot, Peter Kochunov, Laura M Rowland, Liyi Elliot Hong
Regulation of stress response involves top-down mechanisms of the frontal-limbic glutamatergic system. As schizophrenia is associated with glutamatergic abnormalities, we hypothesized that schizophrenia patients may have abnormal glutamatergic reactivity within the dorsal anterior cingulate cortex (dACC), a key region involved in perception of and reaction to stress. To test this, we developed a somatic stress paradigm involving pseudorandom application of safe but painfully hot stimuli to the forearm of participants while they were undergoing serial proton magnetic resonance spectroscopy to measure changes in glutamate and glutamine levels in the dACC...
September 23, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036206/risk-characterization-of-hospitalizations-for-mental-illness-and-or-behavioral-disorders-with-concurrent-heat-related-illness
#20
Michael T Schmeltz, Janet L Gamble
BACKGROUND: Many studies have found significant associations between high ambient temperatures and increases in heat-related morbidity and mortality. Several studies have demonstrated that increases in heat-related hospitalizations are elevated among individuals with diagnosed mental illnesses and/or behavioral disorders (MBD). However, there are a limited number of studies regarding risk factors associated with specific mental illnesses that contribute, at least in part, to heat-related illnesses (HRI) in the United States...
2017: PloS One
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