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https://www.readbyqxmd.com/read/28531220/highly-conserved-type-1-pili-promote-enterotoxigenic-e-coli-pathogen-host-interactions
#1
Alaullah Sheikh, Rasheduzzaman Rashu, Yasmin Ara Begum, F Matthew Kuhlman, Matthew A Ciorba, Scott J Hultgren, Firdausi Qadri, James M Fleckenstein
Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries. Efficient delivery of these toxins requires ETEC to engage target host enterocytes. This engagement is accomplished using a variety of pathovar-specific and conserved E. coli adhesin molecules as well as plasmid encoded colonization factors. Some of these adhesins undergo significant transcriptional modulation as ETEC encounter intestinal epithelia, perhaps suggesting that they cooperatively facilitate interaction with the host...
May 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28509764/environmental-and-physiological-factors-affect-football-head-impact-biomechanics
#2
Jason P Mihalik, Adam Z Sumrall, Susan W Yeargin, Kevin M Guskiewicz, Kevin B King, Scott C Trulock, Edgar W Shields
PURPOSE: Recent anecdotal trends suggest a disproportionate number of head injuries in collegiate football players occur during preseason football camp. In warmer climates, this season also represents the highest risk for heat-related illness among collegiate football players. Since concussion and heat illnesses share many common symptoms, we need 1) to understand if environmental conditions, body temperature, and hydration status affect head impact biomechanics; and 2) to determine if an in-helmet thermistor could provide a valid measure of gastrointestinal temperature...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28505092/molecular-characterization-and-expression-profiling-of-tomato-grf-transcription-factor-family-genes-in-response-to-abiotic-stresses-and-phytohormones
#3
Khadiza Khatun, Arif Hasan Khan Robin, Jong-In Park, Ujjal Kumar Nath, Chang Kil Kim, Ki-Byung Lim, Ill Sup Nou, Mi-Young Chung
Growth regulating factors (GRFs) are plant-specific transcription factors that are involved in diverse biological and physiological processes, such as growth, development and stress and hormone responses. However, the roles of GRFs in vegetative and reproductive growth, development and stress responses in tomato (Solanum lycopersicum) have not been extensively explored. In this study, we characterized the 13 SlGRF genes. In silico analysis of protein motif organization, intron-exon distribution, and phylogenetic classification confirmed the presence of GRF proteins in tomato...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28489460/a-preliminary-study-in-the-alterations-of-mitochondrial-respiration-in-patients-with-carbon-monoxide-poisoning-measured-in-blood-cells
#4
David H Jang, Matthew Kelly, Kevin Hardy, David S Lambert, Frances S Shofer, David M Eckmann
OBJECTIVES: Carbon monoxide (CO) is a colorless and odorless gas responsible for poisoning mortality and morbidity in the United States. At this time, there is no reliable method to predict the severity of poisoning or clinical prognosis following CO exposure. Whole blood cells, such as peripheral blood mononuclear cells (PBMCs) and platelets, have been explored for their potential use to act as sensitive biomarkers for mitochondrial dysfunction which may have a role in CO poisoning. DESIGN: The objective of this study was to measure mitochondrial respiration using intact cells obtained from patients exposed to CO as a potential biomarker for mitochondrial inhibition with results that can be obtained in a time frame useful for guiding clinical care...
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28484148/plasma-endotoxin-activity-in-eastern-grey-kangaroos-macropus-giganteus-with-lumpy-jaw-disease
#5
Yukari Sotohira, Kazuyuki Suzuki, Marina Otsuka, Masakazu Tsuchiya, Toshio Shimamori, Yasunobu Nishi, Kenji Tsukano, Mitsuhiko Asakawa
Progressive pyogranulomatous osteomyelitis involving the mandible or maxilla of captive macropods, referred to as "Lumpy jaw disease (LJD)", is one of the most significant causes of illness and death in captive macropods. The aim of the present study was to evaluate the relationship between the severity of LJD and plasma endotoxin activity in kangaroos. Plasma samples obtained from moderate (n=24) and severe LJD (n=12), and healthy kangaroos (n=46), were diluted 1:20 in endotoxin-free water and heated to 80°C for 10 min...
May 8, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28452907/in-a-mouse-model-of-sepsis-hepcidin-ablation-ameliorates-anemia-more-effectively-than-iron-and-erythropoietin-treatment
#6
Eeman Khorramian, Eileen Fung, Kristine Chua, Victoria Gabayan, Tomas Ganz, Elizabeta Nemeth, Airie Kim
Intensive Care Unit (ICU) anemia is an extreme version of anemia of inflammation (AI) that occurs commonly in critically ill patients and is associated with increased morbidity and mortality. Currently available therapies for ICU anemia have shown inconsistent efficacies in clinical trials. We conducted a systematic study of the effects of early versus delayed iron (Fe) and/or erythropoietin (EPO) therapy in our previously characterized mouse model of ICU anemia based on an injection of heat-killed Brucella abortus (BA)...
April 27, 2017: Shock
https://www.readbyqxmd.com/read/28447137/-climate-change-physical-and-mental-consequences
#7
REVIEW
Maxie Bunz, Hans-Guido Mücke
Climate change has already had a large influence on the human environmental system and directly or indirectly affects physical and mental health. Triggered by extreme meteorological conditions, for example, storms, floods, earth slides and heat periods, the direct consequences range from illnesses to serious accidents with injuries, or in extreme cases fatalities. Indirectly, a changed environment due to climate change affects, amongst other things, the cardiovascular system and respiratory tract, and can also cause allergies and infectious diseases...
April 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28445399/advances-in-psychiatric-diagnosis-past-present-and-future
#8
EDITORIAL
Carol S North, Alina M Surís
This editorial examines controversies identified by the articles in this special issue, which explore psychopathology in the broad history of the classification of selected psychiatric disorders and syndromes over time through current American criteria. Psychiatric diagnosis has a long history of scientific investigation and application, with periods of rapid change, instability, and heated controversy associated with it. The articles in this issue examine the history of psychiatric nomenclature and explore current and future directions in psychiatric diagnosis through the various versions of accepted diagnostic criteria and accompanying research literature addressing the criteria...
April 26, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28436284/exertional-heat-illness-among-secondary-school-athletes
#9
Jill Rodgers, Peggy Slota, Beth Zamboni
Exertional heat illness (EHI) is a leading cause of preventable death among student athletes. While causes and preventative measures for EHI are known, school districts may not be implementing evidence-based practices. This descriptive, exploratory study explored school policies, resources, and practices of coaches in a mid-Atlantic state in the prevention and identification of EHI; 397 responded. Ninety-three percent knew of EHI, but only 52% scheduled acclimatization. Coaches reporting a heat emergency plan (56%) were significantly more likely to follow other evidence-based recommendations: altering equipment ( p < ...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/28430667/enhanced-thermal-imaging-of-wound-tissue-for-better-clinical-decision-making
#10
Ellen Keenan, Georgina Gethin, Louisa Flynn, David Watterson, Gerard M O'Connor
Infrared cameras are increasingly applied in clinical applications as they allow fast, inexpensive and non-contact temperature measurements. As abnormal heat distribution can indicate illness, infrared cameras have been applied in the prediction, diagnosis and monitoring of medical conditions. Current practices, however, often overlook the importance of emissivity when taking thermal measurements. The consensus is that human skin has an emissivity of 0.98 but this value varies between individuals, areas examined, and if the skin is damaged...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28422207/oxygen-thermomigration-in-acceptor-doped-perovskite
#11
Donghoon Shin, Han-Ill Yoo
The recent proposal of possible oxygen-thermomigration as a plausible mechanism for unipolar resistive switching of oxide memristors is now widely employed in modelling or simulating their memristive function on the grounds of the conventional picture that the mobile component O is always thermophobic, with its reduced heat-of-transport being equal to its migrational enthalpy (qO* = ΔHm > 0). At 1000 °C, we measured the thermomigration of mobile-component O in a prototype memristive perovskite, CaTi0.90Sc0...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28414703/recruitment-methods-and-descriptive-results-of-a-physiologic-assessment-of-latino-farmworkers-the-california-heat-illness-prevention-study
#12
Diane C Mitchell, Javier Castro, Tracey L Armitage, Alondra J Vega-Arroyo, Sally C Moyce, Daniel J Tancredi, Deborah H Bennett, James H Jones, Tord Kjellstrom, Marc B Schenker
OBJECTIVE: The California heat illness prevention study (CHIPS) devised methodology and collected physiological data to assess heat related illness (HRI) risk in Latino farmworkers. METHODS: Bilingual researchers monitored HRI across a workshift, recording core temperature, work rate (metabolic equivalents [METs]), and heart rate at minute intervals. Hydration status was assessed by changes in weight and blood osmolality. Personal data loggers and a weather station measured exposure to heat...
April 14, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28411725/effects-of-heat-stress-on-risk-perceptions-and-risk-taking
#13
Chu-Hsiang Chang, Thomas E Bernard, Jennifer Logan
Exposure to extreme heat at work is a serious occupational hazard, as exposure can result in heat-related illnesses, and it has been linked to increased risk of accidents and injuries. The current study aimed to examine whether heat exposure is related to changes in individuals' psychological process of risk evaluation, and whether acclimatization can mitigate the effect of heat exposure. A study with quasi-experiment research design was used to compare participants' risk perceptions and risk-taking behaviors at baseline, initial exposure to heat, and exposure after acclimatization across male participants who were exposed to heat (N = 6), and males (N = 5) and females (N = 6) who were in the control group who were exposed to ambient temperature...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28408306/heart-failure-and-thermoregulatory-control-can-patients-with-heart-failure-handle-the-heat
#14
REVIEW
Bryce N Balmain, Surendran Sabapathy, Ollie Jay, Julie Adsett, Glenn M Stewart, Rohan Jayasinghe, Norman R Morris
Upon heat exposure, the thermoregulatory system evokes reflex increases in sweating and skin blood flow responses to facilitate heat dissipation and maintain heat balance to prevent the continuing rise in core temperature. These heat dissipating responses are mediated primarily by autonomic and cardiovascular adjustments; which if attenuated, may compromise thermoregulatory control. In patients with heart failure (HF), the neurohumoral and cardiovascular dysfunction that underpins this condition may potentially impair thermoregulatory responses and, consequently, place these patients at a greater risk of heat-related illness...
April 10, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28402203/hydration-and-cooling-practices-among-farmworkers-in-oregon-and-washington
#15
Jeffrey W Bethel, June T Spector, Jennifer Krenz
BACKGROUND: Although recommendations for preventing occupational heat-related illness among farmworkers include hydration and cooling practices, the extent to which these recommendations are universally practiced is unknown. The objective of this analysis was to compare hydration and cooling practices between farmworkers in Oregon and Washington. METHODS: A survey was administered to a purposive sample of Oregon and Washington farmworkers. Data collected included demographics, work history and current work practices, hydration practices, access and use of cooling measures, and headwear and clothing worn...
April 12, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28389141/luteolin-restricts-dengue-virus-replication-through-inhibition-of-the-proprotein-convertase-furin
#16
Minhua Peng, Satoru Watanabe, Kitti Wing Ki Chan, Qiuyan He, Ya Zhao, Zhongde Zhang, Xiaoping Lai, Dahai Luo, Subhash G Vasudevan, Geng Li
In many countries afflicted with dengue fever, traditional medicines are widely used as panaceas for illness, and here we describe the systematic evaluation of a widely known natural product, luteolin, originating from the "heat clearing" class of herbs. We show that luteolin inhibits the replication of all four serotypes of dengue virus, but the selectivity of the inhibition was weak. In addition, ADE-mediated dengue virus infection of human cell lines and primary PBMCs was inhibited. In a time-of-drug-addition study, luteolin was found to reduce infectious virus particle formation, but not viral RNA synthesis, in Huh-7 cells...
April 5, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28388909/hospitalizations-for-heat-stress-illness-varies-between-rural-and-urban-areas-an-analysis-of-illinois-data-1987-2014
#17
Jyotsna S Jagai, Elena Grossman, Livia Navon, Apostolis Sambanis, Samuel Dorevitch
BACKGROUND: The disease burden due to heat-stress illness (HSI), which can result in significant morbidity and mortality, is expected to increase as the climate continues to warm. In the United States (U.S.) much of what is known about HSI epidemiology is from analyses of urban heat waves. There is limited research addressing whether HSI hospitalization risk varies between urban and rural areas, nor is much known about additional diagnoses of patients hospitalized for HSI. METHODS: Hospitalizations in Illinois for HSI (ICD-9-CM codes 992...
April 7, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28379784/evaluation-of-diagnostic-codes-in-morbidity-and-mortality-data-sources-for-heat-related-illness-surveillance
#18
Laurel Harduar Morano, Sharon Watkins
OBJECTIVES: The primary objective of this study was to identify patients with heat-related illness (HRI) using codes for heat-related injury diagnosis and external cause of injury in 3 administrative data sets: emergency department (ED) visit records, hospital discharge records, and death certificates. METHODS: We obtained data on ED visits, hospitalizations, and deaths for Florida residents for May 1 through October 31, 2005-2012. To identify patients with HRI, we used codes from the International Classification of Diseases, Ninth Revision, Clinical Modification ( ICD-9-CM) to search data on ED visits and hospitalizations and codes from the International Classification of Diseases, Tenth Revision ( ICD-10) to search data on deaths...
May 2017: Public Health Reports
https://www.readbyqxmd.com/read/28358522/update-exertional-hyponatremia-active-component-u-s-armed-forces-2001-2016
#19
(no author information available yet)
From 2001 through 2016, there were 1,519 incident diagnoses of exertional hyponatremia among active component service members (incidence rate: 6.9 cases per 100,000 person-years [p-yrs]). The incidence rate in 2016 (6.6 cases per 100,000 p-yrs) represented a decrease of 23.3% from 2015. Compared to their respective counterparts, overall incidence rates of exertional hyponatremia were higher among females, those aged 19 years or younger, and recruit trainees. The overall incidence rate during the surveillance period was highest in the Marine Corps, intermediate in the Army and Air Force, and lowest in the Navy...
March 2017: MSMR
https://www.readbyqxmd.com/read/28358520/update-heat-illness-active-component-u-s-armed-forces-2016
#20
(no author information available yet)
In 2016, there were 2,536 incident diagnoses of heat illness among active component service members (incidence rate: 1.96 cases per 1,000 person-years [p-yrs]). The overall crude incidence rates of heat stroke and "other heat illness" were 0.31 and 1.65 per 1,000 p-yrs, respectively. In 2016, subgroup-specific incidence rates of heat stroke were highest among males and service members aged 19 years or younger, Asian/Pacific Islanders, Marine Corps and Army members, recruit trainees, and those in combat-specific and "other" occupations...
March 2017: MSMR
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