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https://www.readbyqxmd.com/read/28633970/unified-neural-field-theory-of-brain-dynamics-underlying-oscillations-in-parkinson-s-disease-and-generalized-epilepsies
#1
E J Müller, S J van Albada, J W Kim, P A Robinson
The mechanisms underlying pathologically synchronized neural oscillations in Parkinson's disease (PD) and generalized epilepsies are explored in parallel via a physiologically-based neural field model of the corticothalamic-basal ganglia (CTBG) system. The basal ganglia (BG) are approximated as a single effective population and their roles in the modulation of oscillatory dynamics of the corticothalamic (CT) system and vice versa are analyzed. In addition to normal EEG rhythms, enhanced activity around 4 Hz and 20 Hz exists in the model, consistent with the characteristic frequencies observed in PD...
June 17, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28633091/cyclic-alternating-pattern-and-interictal-epileptiform-discharges-during-morning-sleep-after-sleep-deprivation-in-temporal-lobe-epilepsy
#2
Filippo Sean Giorgi, Michelangelo Maestri, Melania Guida, Luca Carnicelli, Lorenzo Caciagli, Raffaele Ferri, Ubaldo Bonuccelli, Enrica Bonanni
PURPOSE: Sleep deprivation (SD) increases the occurrence of interictal epileptiform discharges (IED) compared to basal EEG in temporal lobe epilepsy (TLE). In adults, EEG after SD is usually performed in the morning after SD. We aimed to evaluate whether morning sleep after SD bears additional IED-inducing effects compared with nocturnal physiological sleep, and whether changes in sleep stability (described by the cyclic alternating pattern-CAP) play a significant role. METHODS: Adult patients with TLE underwent in-lab night polysomnography (n-PSG) and, within 7days from n-PSG, they underwent also a morning EEG after night SD (SD-EEG)...
June 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28622122/exploding-head-syndrome-in-the-epilepsy-monitoring-unit-case-report-and-literature-review
#3
Kara Gillis, Marcus C Ng
Diagnosis of paroxysmal events in epilepsy patients is often made through video-telemetry electroencephalography in the epilepsy monitoring unit. This case report describes the first-ever diagnosis of exploding head syndrome in a patient with longstanding epilepsy and novel nocturnal events. In this report, we describe the presentation of exploding head syndrome and its prevalence and risk factors. In addition, the prevalence of newly diagnosed sleep disorders through video-telemetry electroencephalography in the epilepsy monitoring unit is briefly reviewed...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/28584610/the-usefulness-of-nap-sleep-recording-during-routine-electroencephalography-an-audit-study
#4
Sami Farah Al-Rawas, Khidir M Abdelbasit, Huda Hussain Al-Lawati, Rajesh Poothrikovil, Amal Khalfan Al-Rawahi, Abdul Aleem Khan, Robert Shane Delamont
OBJECTIVES: A measure to increase the electroencephalogram (EEG) outcome includes a short period of nap sleep during a routine standard EEG with the aim of increasing its sensitivity to interictal abnormalities or provoking seizures. As part of an ongoing auditing of our EEG data, we aimed to investigate the contribution of nap sleep during routine outpatient department based EEGs requested for a variety of reasons. METHODS: EEG data at the Department of Clinical Physiology at Sultan Qaboos University Hospital, Oman, from July 2006 to December 2007 and from January 2009 to December 2010 (total 42 months) were reviewed...
May 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28576131/analysis-of-31-year-old-patient-with-syngap1-gene-defect-points-to-importance-of-variants-in-broader-splice-regions-and-reveals-developmental-trajectory-of-syngap1-associated-phenotype-case-report
#5
Darina Prchalova, Marketa Havlovicova, Katalin Sterbova, Viktor Stranecky, Miroslava Hancarova, Zdenek Sedlacek
BACKGROUND: Whole exome sequencing is a powerful tool for the analysis of genetically heterogeneous conditions. The prioritization of variants identified often focuses on nonsense, frameshift and canonical splice site mutations, and highly deleterious missense variants, although other defects can also play a role. The definition of the phenotype range and course of rare genetic conditions requires long-term clinical follow-up of patients. CASE PRESENTATION: We report an adult female patient with severe intellectual disability, severe speech delay, epilepsy, autistic features, aggressiveness, sleep problems, broad-based clumsy gait and constipation...
June 2, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28575759/development-of-a-web-based-executive-functioning-intervention-for-adolescents-with-epilepsy-the-epilepsy-journey
#6
Avani C Modi, Matthew Schmidt, Aimee W Smith, Luke Turnier, Noah Glaser, Shari L Wade
INTRODUCTION: Youth with epilepsy exhibit significant deficits in executive functioning (EF), yet there are few interventions to improve EF for adolescents. The aims of the current study were to develop an individually-tailored intervention, called Epilepsy Journey, to improve aspects of EF through an iterative, patient-centered process including focus groups and usability testing. METHODS: Five adolescents and caregivers participated in focus groups. This input was used to develop ten learning modules based on subscales of the Behavioral Rating Inventory of Executive Functions and key issues that may impact EF in adolescents...
May 30, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28555759/postictal-generalized-eeg-suppression-and-respiratory-dysfunction-following-generalized-tonic-clonic-seizures-in-sleep-and-wakefulness
#7
Weifeng Peng, Jessica L Danison, Masud Seyal
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is a common cause of death in epilepsy and frequently occurs following generalized tonic-clonic seizures (GTCS) in sleep. Postictal generalized electroencephalography (EEG) suppression (PGES), postictal immobility, and periictal respiratory dysfunction are potential risk factors for SUDEP. We sought to determine whether there was a difference in respiratory dysfunction, PGES, and postictal immobility for GTCS occurring during wakefulness or sleep...
May 28, 2017: Epilepsia
https://www.readbyqxmd.com/read/28555070/absence-seizure-control-by-a-brain-computer-interface
#8
Vladimir A Maksimenko, Sabrina van Heukelum, Vladimir V Makarov, Janita Kelderhuis, Annika Lüttjohann, Alexey A Koronovskii, Alexander E Hramov, Gilles van Luijtelaar
The ultimate goal of epileptology is the complete abolishment of epileptic seizures. This might be achieved by a system that predicts seizure onset combined with a system that interferes with the process that leads to the onset of a seizure. Seizure prediction remains, as of yet, unresolved in absence-epilepsy, due to the sudden onset of seizures. We have developed a real-time absence seizure prediction algorithm, evaluated it and implemented it in an on-line, closed-loop brain stimulation system designed to prevent the spike-wave-discharges (SWDs), typical for absence epilepsy, in a genetic rat model...
May 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28542864/circadian-clustering-of-spontaneous-epileptic-seizures-emerges-after-pilocarpine-induced-status-epilepticus
#9
Julika Pitsch, Albert J Becker, Susanne Schoch, Johannes Alexander Müller, Marco de Curtis, Vadym Gnatkovsky
OBJECTIVE: Seizures in mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis are thought to develop with various latency intervals after an initial transient brain insult. To study seizure dynamics after an initial transient precipitating insult in a systematic fashion, we utilized continuous video-electroencephalography (EEG) monitoring after the induction of status epilepticus (SE) in a mouse MTLE model. METHODS: Continuous 24/7 video/telemetric hippocampal EEG recordings in the systemic pilocarpine MTLE mouse model...
May 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/28542735/sleep-convulsive-seizures-predict-lack-of-remission-in-genetic-generalized-epilepsies-a-retrospective-study-from-a-single-epilepsy-center-in-egypt
#10
A Ashmawi, H Hosny, M Gadallah, E Beghi
BACKGROUND: Genetic generalized epilepsies (GGEs) represent 15-20% of all epilepsies. There are no studies on the outcome of GGEs in the Middle East. AIMS: To investigate the long-term prognosis of GGEs and identify prognostic predictors in Egypt. MATERIAL & METHODS: This is a retrospective cohort study of consecutive children and adults with GGEs seen in an epilepsy clinic in Cairo, Egypt, followed for 10+ years. Follow-up visits were scheduled every 3-6 months or earlier...
May 21, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28535638/-application-of-long-term-video-electroencephalogram-and-resting-state-functional-magnetic-resonance-imaging-in-detection-of-cognition-in-patients-with-benign-epilepsy-of-childhood-with-centrotemporal-spikes
#11
X X Yan, Q Yu, Y T Gao, L T Li, D H Yu, Y Chen, X J Yao, W D Yang, Z J Chen, J Z Yin, Y An, K Tan
Objective: To study the relationship between the changes of brain network and cognition in patients with benign epilepsy of childhood with centrotemporal spikes (BECTS) by using long term video electroencephalogram (VEEG) and resting-state functional magnetic resonance imaging (RS-fMRI) technology. Methods: Eleven patients with right-handed were recruited (from April 2015 to September 2016) from epilepsy specialist outpatients and functional department of neurosurgery of Tianjin Medical University General Hospital...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28532713/electroencephalography-after-a-single-unprovoked-seizure
#12
REVIEW
Derek B Debicki
Electroencephalography (EEG) is an essential diagnostic tool in the evaluation of seizure disorders. In particular, EEG is used as an additional investigation for a single unprovoked seizure. Epileptiform abnormalities are related to seizure disorders and have been shown to predict recurrent unprovoked seizures (i.e., a clinical definition of epilepsy). Thus, the identification of epileptiform abnormalities after a single unprovoked seizure can inform treatment options. The current review addresses the relationship between EEG abnormalities and seizure recurrence...
July 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28511919/the-debate-treatment-after-the-first-seizure-the-pro
#13
REVIEW
David G Olmes, Hajo M Hamer
According to current diagnosis criteria, first seizures constitute beginning epilepsy when they carry recurrence risks of ≥60% over the next 10 years. This is frequently the case and warrants AED treatment. Evidence argues against deferring treatment when provoking factors such as sleep deprivation are reported. There are several characteristics of first seizures which markedly increase recurrence risk but not clearly beyond 60%. This includes status epilepticus or seizure flurries at first manifestation or focal semiology indicating focal epilepsy...
July 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28501473/electrical-status-epilepticus-during-sleep-in-mowat-wilson-syndrome
#14
Paolo Bonanni, Susanna Negrin, Anna Volzone, Nicoletta Zanotta, Roberta Epifanio, Claudio Zucca, Elisa Osanni, Elisa Petacchi, Franco Fabbro
AIM: Mowat-Wilson Syndrome (MWS) is a genetic rare disease. Epilepsy is present in 70-75% of Patients and an age-dependent electroclinical pattern has been described. Up to date, there are studies with overnight sleep EEGs, probably because of the severe intellectual disability (ID) and hyperactivity of these Patients. Our purpose was to verify the hypothesis that MWS Patients might have electrical status epilepticus in slow wave sleep (ESES pattern). METHODS: A retrospective analysis of anamnestic and electrographic data was performed on 7 consecutive MWS Patients followed between 2007 and 2016...
May 10, 2017: Brain & Development
https://www.readbyqxmd.com/read/28486925/the-mutual-interaction-between-sleep-and-epilepsy-on-the-neurobiological-basis-and-therapy
#15
Yi-Qun Wang, Meng-Qi Zhang, Rui Li, Wei-Min Qu, Zhi-Li Huang
Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our understanding of this relationship remains unclear. In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them. The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non-rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Neuromodulators-such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine-promote wakefulness and are considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep...
May 8, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28482107/phasic-rem-transiently-approaches-wakefulness-in-the-human-cortex-a-single-pulse-electrical-stimulation-study
#16
Kiyohide Usami, Riki Matsumoto, Katsuya Kobayashi, Takefumi Hitomi, Masao Matsuhashi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
Study Objectives: To investigate the changes in cortical neural responses induced by external inputs during phasic rapid eye movement (REM) sleep. Methods: Single-pulse electrical stimulation (SPES) was directly applied to the human cortex during REM sleep through subdural electrodes, in seven patients who underwent invasive presurgical evaluation for intractable partial epilepsy. SPES was applied to parts of the cortex through the subdural electrodes, and induced cortical responses were recorded from adjacent and remote cortical areas...
May 8, 2017: Sleep
https://www.readbyqxmd.com/read/28464288/electroclinical-findings-of-minor-motor-events-during-sleep-in-temporal-lobe-epilepsy
#17
Loretta Giuliano, Denise Uccello, Daniela Fatuzzo, Greta Mainieri, Mario Zappia, Vito Sofia
OBJECTIVE: It is well known that sleep-related motor seizures can originate from the temporal lobe. However, little is known about the clinical features of minor motor manifestations during sleep in patients with temporal lobe epilepsy. The main objective of our study was to verify the existence of minor motor events during sleep in patients with mesial temporal lobe epilepsy (MTLE) and to define their clinical features and electroencephalography (EEG) correlations. METHODS: We enrolled in the study patients with diagnosis of symptomatic MTLE and a group of healthy controls...
May 2, 2017: Epilepsia
https://www.readbyqxmd.com/read/28463934/occipito-frontal-sharp-waves-an-under-recognized-electroencephalogram-pattern-in-self-limited-idiopathic-childhood-focal-epilepsy
#18
Elaine Wyllie, Ahsan N V Moosa
We report four children who highlight the potentially under-recognized electroencephalogram pattern of bilaterally synchronous occipito-frontal sharp waves, which may occur in children with Panayiotopoulos type self-limited childhood epilepsy but may be easily confused with the patterns of symptomatic generalized epilepsy. Our patients were young, healthy children who had infrequent, predominantly nocturnal, fairly prolonged seizures characterized by altered consciousness, vomiting, and autonomic features, or in one case nocturnal secondary generalized tonic-clonic convulsion...
May 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28460319/altered-mt1-and-mt2-melatonin-receptors-expression-in-the-hippocampus-of-pilocarpine-induced-epileptic-rats
#19
Anna Karynna Alves de Alencar Rocha, Eliangela de Lima, Fernanda Amaral, Rafael Peres, José Cipolla-Neto, Débora Amado
Clinical and experimental findings show that melatonin may be used as an adjuvant to the treatment of epilepsy-related complications by alleviates sleep disturbances, circadian alterations and attenuates seizures alone or in combination with AEDs. In addition, it has been observed that there is a circadian component on seizures, which cause changes in circadian system and in melatonin production. Nevertheless, the dynamic changes of the melatoninergic system, especially with regard to its membrane receptors (MT1 and MT2) in the natural course of TLE remain largely unknown...
June 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28452654/epilepsy-surgery-for-epileptic-encephalopathy-as-a-sequela-of-herpes-simplex-encephalitis-case-report
#20
Birce Dilge Taskin, Kurenai Tanji, Neil A Feldstein, Maureen McSwiggan-Hardin, Cigdem I Akman
Herpes simplex virus (HSV) encephalitis can manifest with different clinical presentations, including acute monophasic illness and biphasic chronic granulomatous HSV encephalitis. Chronic encephalitis is much less common, and very rare late relapses are associated with intractable epilepsy and progressive neurological deficits with or without evidence of HSV in the cerebrospinal fluid. The authors report on an 8-year-old girl with a history of treated HSV-1 encephalitis when she was 13 months of age and focal epilepsy when she was 2 years old...
April 28, 2017: Journal of Neurosurgery. Pediatrics
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