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P Hadji, K A Ryan, C-R Yu, S Mirkin, Barry S Komm
OBJECTIVES: To evaluate the efficacy of conjugated estrogens/bazedoxifene (CE/BZA) on bone mineral density (BMD), bone turnover markers (BTM), and menopause-specific quality of life (MENQOL) in European women. METHODS: Data through 12 months were pooled from two double-blind, randomized, controlled trials in non-hysterectomized postmenopausal women who received CE/BZA or placebo. Women from European study sites with evaluable BMD (n = 60), BTM (n = 56), and MENQOL questionnaire (n = 236) data were included and compared with 1523 women from US study sites (n = 730 with evaluable data for bone outcomes)...
October 2016: Climacteric: the Journal of the International Menopause Society
Adam Tucker, Darren McCusker, Nidhi Gupta, Jonathon Bunn, Mark Murnaghan
INTRODUCTION: Arthroplasty is commonplace in orthopaedic practice, and post operative pain has been shown to substantially hinder recovery and discharge from hospital. OBJECTIVES: The current study assessed a multidisciplinary, multimodal Orthopaedic ERP in terms of its effect on patient perceived post operative pain in hip and knee arthroplasty. Secondary outcome was in the form of a cost analysis. METHODS: A prospective study was performed on consecutive arthroplasty patients across a 6 week period in a district orthopaedic unit...
May 2016: Ulster Medical Journal
Saiprasad Ravi, Mark Zhu, Christopher Luey, Simon W Young
BACKGROUND: Prophylactic antibiotics significantly reduce prosthetic joint infection (PJI) rates after hip and knee arthroplasty. However, rising antibiotic resistance has raised concerns over the adequacy of conventional prophylaxis. This study aimed to identify organisms causing PJIs in hip and knee arthroplasty secondary to perioperative contamination and their susceptibility to current prophylactic antibiotics. METHODS: We performed a retrospective audit of 4009 primary hip and knee arthroplasties (1852 hips and 2157 knees) at three tertiary referral hospitals...
August 25, 2016: ANZ Journal of Surgery
L Pei, Z W Guan, X J Ji, Q F Wen, F Sun, Z Zhao, J Y Jin, J Zhu, J L Zhang, F Huang
Objective: To investigate the value of (18)F fluorodeoxyglucose-positron emission tomography/computed tomography ((18)F FDG-PET-CT) in the diagnosis and the evaluation of disease activity and remission of dermatomyositis(DM). Methods: DM patients who were admitted to the Department of Rheumatology, the People's Liberation Army General Hospital (PLAGH) and underwent (18)F FDG-PET-CT examination were retrospectively reviewed from January 2012 to May 2015.Gender and age matched healthy controls (HC) were also enrolled...
July 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
U Dorn, F Landauer, T Hofstaedter
Gluteal tendinopathy as well as partial and full-thickness tears of gluteal tendons (gluteus minimus and/or medius tendon) were underestimated as a cause of chronic pain in the past, and treatment was most commonly based on the diagnosis of trochanteric bursitis. Tendinous pathologies can either stay asymptomatic or cause pain and muscular dysfunction, not necessarily being associated with osteoarthritis of the hip 1. As the terminus "rotator cuff tear of the hip" was published in 1997 2, its aetiopathogenesis was reconsidered, resulting in improvements in diagnosis and treatment...
June 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
M Kalder, I Kyvernitakis, O Hars, A Kauka, P Hadji
OBJECTIVES: To compare the effects on bone mineral density (BMD) measured by dual-energy X-ray absorptiometry at the lumbar spine, the femoral neck and the total hip following 2 years of treatment with a low-dose combined hormone therapy (HT) comprised of 1 mg estradiol and 0.5 mg norethisterone acetate (E2/NETA) versus 2.5 mg tibolone in postmenopausal women. Additionally, quantitative ultrasonometry (QUS) of the os calcaneus and of the phalanges was performed. METHODS: Changes in BMD, QUS and side-effects were assessed at baseline, 6, 12 and 24 months in 50 postmenopausal women who received either E2/NETA (n = 26) or tibolone (n = 24) for 2 years...
October 2016: Climacteric: the Journal of the International Menopause Society
P D Miller, N Pannacciulli, J P Brown, E Czerwinski, B S Nedergaard, M A Bolognese, J Malouf, H G Bone, J-Y Reginster, A Singer, C Wang, R B Wagman, S R Cummings
CONTEXT: Denosumab and zoledronic acid (ZOL) are parenteral treatments for patients with osteoporosis. OBJECTIVE: The objective of the study was to compare the effect of transitioning from oral bisphosphonates to denosumab or ZOL on bone mineral density (BMD) and bone turnover. DESIGN AND SETTING: This was an international, multicenter, randomized, double-blind trial. PARTICIPANTS: A total of 643 postmenopausal women with osteoporosis previously treated with oral bisphosphonates participated in the study...
August 2016: Journal of Clinical Endocrinology and Metabolism
Nicola Rani, Giacomo Sabbioni, Alessandro Mazzotta, Martina Rocchi, Cesare Stagni, Mattia Filanti, Dante Dallari
Osteoarthritis (OA) is a very common disease, its prevalence increases with age and is a frequent cause of disability.Osteoarthritis is characterised by joint pain, stiffness and loss of range of motion. Overall, as many as 40% of those aged over 65 years in the community may have symptomatic OA of the knee or hip (1). OA results from a complex interaction of biomechanical and biochemical factors and is characterised by cartilage disruption and hypertrophy of bone. Intraarticular proinflammatory cytokines and proteinases in OA interfere with the synthesis of hyaluronic acid (HA), a complex glycosaminoglycan composed of repeated disaccharide units to form a linear polymer, resulting in an HA with a significantly reduced molecular weight and a reduction in synovial fluid viscoelasticity (2-3)...
May 14, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
M Crespo, J Navarro, M Martinez-Rebollar, D Podzamczer, P Domingo, J Mallolas, M Saumoy, G M Mateo, A Curran, J Gatell, E Ribera
OBJECTIVE: To compare 48-week changes in bone mineral density (BMD) and body fat distribution between patients continuing lopinavir/ritonavir and two NRTIs and those switching to lopinavir/ritonavir and lamivudine. METHODS: Substudy of a randomized, open-label, multicenter OLE study was carried out. Adult HIV-infected patients with <50 copies/mL for ≥6 months were randomized (1:1) to continue lopinavir/ritonavir and two NRTIs or switching to lopinavir/ritonavir and lamivudine...
May 2016: HIV Clinical Trials
C Beaudoin, S Jean, L Bessette, L-G Ste-Marie, L Moore, J P Brown
UNLABELLED: The aim of this review is to compare the efficacy and safety of denosumab over other treatments for osteoporosis. The results of this study suggest that the safety of denosumab and its efficacy in reducing fractures is not significantly different from bisphosphonates. Denosumab was, however, more effective in increasing bone mineral density. INTRODUCTION: This study was conducted to compare the efficacy and safety of denosumab over other pharmacological treatments for osteoporosis in individuals at risk of fracture...
September 2016: Osteoporosis International
Young-Kyun Lee, Yong-Chan Ha, Woo-Lam Jo, Tae-Young Kim, Woon-Hwa Jung, Kyung-Hoi Koo
BACKGROUND: Fourth generation (Delta) ceramic bearing was developed to reduce dislocation after total hip arthroplasty (THA) by increasing the head diameter. We tested a hypothesis that 32/36 mm Delta ceramic bearing decreases the dislocation rate. We also evaluated ceramic-related complications and early outcome of this thin liner-on-large head ceramic bearing. METHODS: We performed a prospective study on patients who underwent THA with use of 32/36 mm Delta ceramic bearing...
May 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Seung-Jae Lim, Sang-Min Kim, Dong-Wook Kim, Young-Wan Moon, Youn-Soo Park
PURPOSE: The purpose of this study was to evaluate the results of cementless total hip arthroplasty (THA) using a 32 mm or larger Biolox®delta ceramic-on-ceramic (CoC) bearing in patients with osteonecrosis of the femoral head after a minimum of 5 years of follow-up. MATERIALS AND METHODS: We retrospectively analysed 44 patients (53 hips) who underwent cementless THA using Biolox®delta CoC bearing. There were 33 men (40 hips) and 11 women (13 hips) with the mean age of 49 years...
March 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
David A Wampler, Chloe Pineda, Joan Polk, Emily Kidd, Dale Leboeuf, Marti Flores, Mike Shown, Chetan Kharod, Ronald M Stewart, Craig Cooley
OBJECTIVE: For thirty years, emergency medical services agencies have emphasized limiting spinal motion during transport of the trauma patient to the emergency department. The long spine board (LSB) has been the mainstay of spinal motion restriction practices, despite the paucity of data to support its use. The purpose of this study was to determine reduction in lateral motion afforded by the LSB in comparison to the stretcher mattress alone. METHODS: This was a randomized controlled crossover trial where healthy volunteer subjects were randomly assigned to either LSB or stretcher mattress only...
April 2016: American Journal of Emergency Medicine
Kate A Ward, Ann Prentice, Diana L Kuh, Judith E Adams, Gina L Ambrosini
Evidence for the contribution of individual foods and nutrients to bone health is weak. Few studies have considered hypothesis-based dietary patterns and bone health. We investigated whether a protein-calcium-potassium-rich (PrCaK-rich) dietary pattern over the adult life course, was positively associated with bone outcomes at 60 to 64 years of age. Diet diaries were collected at ages 36, 46, 53, and 60 to 64 years in 1263 participants (661 women) from the MRC National Survey of Health and Development. DXA and pQCT measurements were obtained at age 60 to 64 years, including size-adjusted bone mineral content (SA-BMC) and volumetric bone mineral density (vBMD)...
June 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Laurent Maïmoun, Thibault Mura, Elodie Leprieur, Antoine Avignon, Denis Mariano-Goulart, Ariane Sultan
No abstract text is available yet for this article.
September 2016: Bone
Kumiko Ono, Satoru Ohashi, Hiroyuki Oka, Yuho Kadono, Tetsuro Yasui, Yasunori Omata, Jinju Nishino, Sakae Tanaka, Shigeto Tohma
OBJECTIVES: To investigate the effect of bilateral and unilateral joint disease on the Modified Health Assessment Questionnaire (MHAQ) scores and the differences in joint weighting in rheumatoid arthritis patients. METHODS: A total of 9212 subjects from the Japanese nationwide cohort database NinJa, 2011, were analyzed. The presence or absence of disease in each joint, including swelling and/or tenderness, was investigated. The correlations between bilateral and unilateral disease in each joint and MHAQ scores were investigated using multivariable logistic regression analysis...
July 2016: Modern Rheumatology
Anthony M Reginato, Humberto Riera, Mariflor Vera, Adrian R Torres, Rolando Espinosa, Jorge A Esquivel, Oscar Jair Felipe, Jorge Roman Blas, Oscar Rillo, Silvia Papasidero, Renee Souto, Cesar Rossi, José F Molina, Francisco Ballesteros, Francisco Radrigan, Marlene Guibert, Araceli Chico, María L Gil, Walter Camacho, Lorena Urioste, Abraham K Garcia, Isa Iraheta, Carmen E Gutierrez, Margarita Duarte, Oswaldo Castañeda, Ibsen Coimbra, Roberto Muñoz Louis, John Reveille, Maritza Quintero
BACKGROUND: Latin America is a heterogeneous region made up of different populations, cultures, latitudes, altitudes, and immigrants from different areas and ethnic groups. OBJECTIVE: The purpose of this study is to describe the clinical and demographic profile of patients with osteoarthritis (OA) evaluated by a selected group of rheumatologists in 13 Latin American countries. METHODS: A descriptive, observational, cross-sectional study was conducted in 13 Latin American countries of patients with symptomatic OA...
December 2015: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Rajajeyakumar Manivel, Pirabhu Ravanan, Chenniappan Meenakshisundram, Niranjana Dhanaprakasam, Sivan Arul Selvan Sundramoorthy, Sushmita Sreekumar, Janitha Alagarsamy, Arun Amaladass
INTRODUCTION: Normal vascular is associated with gradual change of vascular structure and function, resulting in increased arterial stiffening and decreased arterial compliance. Arterial stiffness is a marker of vascular ageing and a predictor of cardiovascular events. Premature or early vascular ageing is measured by pulse wave velocity or the arterial augmentation index based on pulse wave analysis. AIM: To study the predictor of vascular dysfunctions in high risk young adult offsprings of type 2 diabetes mellitus and hypertensive parents...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
Carlos Irwin A Oronce, Hui Shao, Lizheng Shi
BACKGROUND: Policymakers have expanded readmissions penalties to include elective total hip arthroplasties (THA), but little is known whether disparities exist on the basis of race, socioeconomic status, or payer. OBJECTIVE: To identify disparities in elective primary THA readmissions based on race, socioeconomic status, and type of insurance. RESEARCH DESIGN: This analysis is a retrospective cohort study of patients discharged for an elective THA...
November 2015: Medical Care
Chei Won Kim, Seokbo Hong, Se Hwan Oh, Jung Jin Lee, Joo Young Han, Seongbin Hong, So Hun Kim, Moonsuk Nam, Yong Seong Kim
Untreated hyperthyroidism and high-dose thyroid hormone are associated with osteoporosis, and increased bone mineral density (BMD) has been demonstrated in postmenopausal females with hypoparathyroidism. Studies on the effect of suppressive levothyroxine (LT4) therapy on BMD and bone metabolism after total thyroidectomy in patients with differentiated thyroid carcinoma have presented conflicting results, and few studies in relation to the status of hypoparathyroidism have been studied. One hundred postmenopausal women and 24 premenopausal women on LT4 suppression therapy were included in this study...
August 2015: Journal of Bone Metabolism
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