Vivek Shukla, Haitao Wang, Lyuba Varticovski, Songjoon Baek, Ruihong Wang, Xinwei Wu, Frank Echtenkamp, Frank Villa Hernandez, Katherine P Prothro, Sudheer K Gara, Mary R Zhang, Stephanie Shiffka, Razi Raziuddin, Leonard M Neckers, W Marston Linehan, Haobin Chen, Gordon L Hager, David S Schrump
BACKGROUND: Recent insights regarding mechanisms mediating stemness, heterogeneity, and metastatic potential of lung cancers have yet to be fully translated to effective regimens for the treatment of these malignancies. This study sought to identify novel targets for lung cancer therapy. METHODS: Transcriptomes and DNA methylomes of 14 SCLC and 10 NSCLC lines were compared to normal human small airway epithelial cells (SAEC) and induced pluripotent stem cell (iPSC) clones derived from SAEC...
April 5, 2024: Journal of Thoracic Oncology