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https://www.readbyqxmd.com/read/28648301/associations-of-early-kidney-disease-with-brain-magnetic-resonance-imaging-and-cognitive-function-in-african-americans-with-type-2-diabetes-mellitus
#1
Barry I Freedman, Kaycee M Sink, Christina E Hugenschmidt, Timothy M Hughes, Jeff D Williamson, Christopher T Whitlow, Nicholette D Palmer, Michael E Miller, Laura C Lovato, Jianzhao Xu, S Carrie Smith, Lenore J Launer, Joshua I Barzilay, Robert M Cohen, Mark D Sullivan, R Nick Bryan, Benjamin C Wagner, Donald W Bowden, Joseph A Maldjian, Jasmin Divers
BACKGROUND: Relationships between early kidney disease, neurocognitive function, and brain anatomy are poorly defined in African Americans with type 2 diabetes mellitus (T2DM). STUDY DESIGN: Cross-sectional associations were assessed between cerebral anatomy and cognitive performance with estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) in African Americans with T2DM. SETTING & PARTICIPANTS: African Americans with cognitive testing and cerebral magnetic resonance imaging (MRI) in the African American-Diabetes Heart Study Memory in Diabetes (AA-DHS MIND; n=512; 480 with MRI) and Action to Control Cardiovascular Risk in Diabetes (ACCORD) MIND (n=484; 104 with MRI) studies...
June 22, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28642500/genome-wide-mapping-of-dnase-i-hypersensitive-sites-reveals-chromatin-accessibility-changes-in-arabidopsis-euchromatin-and-heterochromatin-regions-under-extended-darkness
#2
Yue Liu, Wenli Zhang, Kang Zhang, Qi You, Hengyu Yan, Yuannian Jiao, Jiming Jiang, Wenying Xu, Zhen Su
Light, as the energy source in photosynthesis, is essential for plant growth and development. Extended darkness causes dramatic gene expression changes. In this study, we applied DNase-seq (DNase I hypersensitive site sequencing) to study changes of chromatin accessibility in euchromatic and heterochromatic regions under extended darkness in Arabidopsis. We generated 27 Gb DNase-seq and 67.6 Gb RNA-seq data to investigate chromatin accessibility changes and global gene expression under extended darkness and control condition in Arabidopsis...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28641583/prevalence-and-risk-factors-of-infertility-in-turkey-evidence-from-demographic-and-health-surveys-1993-2013
#3
Melike Sarac, Ismet Koc
The inability to have children affects couples worldwide and causes emotional and psychological distress in both men and women. Turkey is a country that lays particular emphasis on the issue of infertility, especially after experiencing a dramatic fertility decline over the last two decades. This study aimed to understand the changes in the prevalence of infertility in Turkey using three different approaches: the DHS Approach, the Constructed Approach and the Current Duration Approach. Furthermore, the factors contributing to elevated risks of infertility as derived from the Constructed Approach were investigated using four different logistic regression models...
June 23, 2017: Journal of Biosocial Science
https://www.readbyqxmd.com/read/28641443/dissecting-the-accountability-of-parameterized-and-parameter-free-single-hybrid-and-double-hybrid-functionals-for-photophysical-properties-of-tadf-based-oleds
#4
Mojtaba Alipour, Niloofar Karimi
Organic light emitting diodes (OLEDs) based on thermally activated delayed fluorescence (TADF) emitters are an attractive category of materials that have witnessed a booming development in recent years. In the present contribution, we scrutinize the accountability of parameterized and parameter-free single-hybrid (SH) and double-hybrid (DH) functionals through the two formalisms, full time-dependent density functional theory (TD-DFT) and Tamm-Dancoff approximation (TDA), for the estimation of photophysical properties like absorption energy, emission energy, zero-zero transition energy, and singlet-triplet energy splitting of TADF molecules...
June 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28641057/child-anthropometry-data-quality-from-demographic-and-health-surveys-multiple-indicator-cluster-surveys-and-national-nutrition-surveys-in-the-west-central-africa-region-are-we-comparing-apples-and-oranges
#5
Daniel J Corsi, Jessica M Perkins, S V Subramanian
BACKGROUND: There has been limited work comparing survey characteristics and assessing the quality of child anthropometric data from population-based surveys. OBJECTIVE: To investigate survey characteristics and indicators of quality of anthropometric data in children aged 0-59 months from 23 countries in the West Central Africa region. METHODS: Using established methodologies and criteria to examine child age, sex, height, and weight, we conducted a comprehensive assessment and scoring of the quality of anthropometric data collected in 100 national surveys...
2017: Global Health Action
https://www.readbyqxmd.com/read/28640837/identification-and-prediction-of-alternative-transcription-start-sites-that-generate-rod-photoreceptor-specific-transcripts-from-ubiquitously-expressed-genes
#6
Evgenya Y Popova, Anna C Salzberg, Chen Yang, Samuel Shao-Min Zhang, Colin J Barnstable
Transcriptome complexity is substantially increased by the use of multiple transcription start sites for a given gene. By utilizing a rod photoreceptor-specific chromatin signature, and the RefSeq database of established transcription start sites, we have identified essentially all known rod photoreceptor genes as well as a group of novel genes that have a high probability of being expressed in rod photoreceptors. Approximately half of these novel rod genes are transcribed into multiple mRNA and/or protein isoforms through alternative transcriptional start sites (ATSS), only one of which has a rod-specific epigenetic signature and gives rise to a rod transcript...
2017: PloS One
https://www.readbyqxmd.com/read/28601994/radiologic-features-of-dropped-head-syndrome-in-the-overall-sagittal-alignment-of-the-spine
#7
Kazuki Hashimoto, Hiroshi Miyamoto, Terumasa Ikeda, Masao Akagi
PURPOSE: Dropped head syndrome (DHS) is a rare clinical entity which is defined as a chin-on-chest deformity in the standing or sitting position, resulting from sagittal imbalance of the cervical region. The purpose of the present study was to clarify the radiologic features of DHS in the overall sagittal alignment of the spine. We also investigated the changes in sagittal alignment after correction surgery for DHS. METHODS: Twenty DHS patients [1 male and 19 female, with an average age of 78...
June 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28594828/an-individual-level-meta-analysis-assessing-the-impact-of-community-level-sanitation-access-on-child-stunting-anemia-and-diarrhea-evidence-from-dhs-and-mics-surveys
#8
David A Larsen, Thomas Grisham, Erik Slawsky, Lutchmie Narine
BACKGROUND: A lack of access to sanitation is an important risk factor child health, facilitating fecal-oral transmission of pathogens including soil-transmitted helminthes and various causes of diarrheal disease. We conducted a meta-analysis of cross-sectional surveys to determine the impact that community-level sanitation access has on child health for children with and without household sanitation access. METHODOLOGY/PRINCIPAL FINDINGS: Using 301 two-stage demographic health surveys and multiple indicator cluster surveys conducted between 1990 and 2015 we calculated the sanitation access in the community as the proportion of households in the sampled cluster that had household access to any type of sanitation facility...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28593806/a-nitrogen-removal-system-to-limit-water-exchange-for-recirculating-freshwater-aquarium-using-dhs-usb-reactor
#9
Nur Adlin, Norihisa Matsuura, Yuki Ohta, Yuga Hirakata, Shinya Maki, Masashi Hatamoto, Takashi Yamaguchi
This study proposes a biological nitrogen removal system for freshwater aquaria consisting of a down-flow hanging sponge (DHS) and an up-flow sludge blanket (USB). DHS-USB systems can perform nitrification and denitrification simultaneously, reducing ammonia (NH3) and nitrate (NO3(-)) toxicity in the water. The performance of the system was evaluated using on-site fresh water aquaria at ambient temperature (23-34°C) over 192 days. NH3 and nitrite (NO2(-)) were maintained at a detection limit of 0.01 mg N L(-1) and NO3(-) was maintained below 10 mg N L(-1), despite limited water exchange...
June 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28588998/significance-of-informal-on-the-job-learning-and-leadership-development-in-health-systems-lessons-from-a-district-finance-team-in-south-africa
#10
S Choonara, J Goudge, N Nxumalo, J Eyles
BACKGROUND: The district health system (DHS) has a critical role to play in the delivery of primary healthcare (PHC). Effective district management, particularly leadership is considered to be crucial element of the DHS. Internationally, the debate around developing leadership competencies such as motivation or empowerment of staff, managing relationships, being solution driven as well as fostering teamwork are argued to be possible through approaches such as formal and informal training...
January 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28587778/advanced-method-optimization-for-volatile-aroma-profiling-of-beer-using-two-dimensional-gas-chromatography-time-of-flight-mass-spectrometry
#11
Pierre-Hugues Stefanuto, Katelynn A Perrault, Lena M Dubois, Benjamin L'Homme, Catherine Allen, Caitriona Loughnane, Nobuo Ochiai, Jean-François Focant
The complex mixture of volatile organic compounds (VOCs) present in the headspace of Trappist and craft beers was studied to illustrate the efficiency of thermal desorption (TD) comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS) for highlighting subtle differences between highly complex mixtures of VOCs. Headspace solid-phase microextraction (HS-SPME), multiple (and classical) stir bar sorptive extraction (mSBSE), static headspace (SHS), and dynamic headspace (DHS) were compared for the extraction of a set of 21 representative flavor compounds of beer aroma...
June 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28585900/strategies-for-the-screening-of-antibiotic-residues-in-eggs-comparison-of-the-validation-of-classical-microbiological-method-with-an-immunobiosensor-method
#12
Valérie Gaudin, Annie Rault, Celine Hedou, Christophe Soumet, Eric Verdon
Efficient screening methods are needed to control antibiotic residues in eggs. A microbiological kit (Explorer® 2.0 test (Zeu Inmunotech, Spain)) and an immunobiosensor kit (Microarray II (AM® II) on the Evidence Investigator™ system (Randox, UK)) have been evaluated and validated for screening of antibiotic residues in eggs, according to Decision EC/2002/657 (2002) and to the European guideline for the validation of screening methods (Crl 2010). The e-reader™ system, a new automatic incubator/reading system, was coupled to the Explorer® 2...
June 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28584091/dissecting-bmp-signaling-input-into-the-gene-regulatory-networks-driving-specification-of-the-blood-stem-cell-lineage
#13
Arif Kirmizitas, Stuart Meiklejohn, Aldo Ciau-Uitz, Rachel Stephenson, Roger Patient
Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenesis. They emerge from a specialized endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dorsal aorta (DA). In Xenopus, we have been studying the gene regulatory networks (GRNs) required for the formation of HSCs, and critically found that the hemogenic potential is defined at an earlier time point when precursors to the DA express hematopoietic as well as endothelial genes, in the definitive hemangioblasts (DHs)...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28583419/modified-dynamic-hip-screw-loaded-with-autologous-bone-graft-for-treating-pauwels-type-3-vertical-femoral-neck-fractures
#14
Deqing Luo, Weitao Zou, Yijiao He, Hang Xian, Lei Wang, Jiazuo Shen, Kejian Lian, Dasheng Lin
INTRODUCTION: Management of Pauwels type-3 vertical femoral neck fractures has been a challenging clinical problem as they experience high shear forces and thus a greater risk of treatment failure. There is no apparent consensus on the optimal implant type for these injuries. We developed a modified dynamic hip screw (DHS), which was designed to a cage in the lag screw, loaded with autologous bone graft for the treatment of Pauwels type-3 vertical femoral neck fractures. METHODS: Between February 2010 and January 2012, 17 consecutive patients with Pauwels type-3 vertical femoral neck fractures were treated with the modified DHS loaded with autologous bone graft...
May 26, 2017: Injury
https://www.readbyqxmd.com/read/28575856/trans-4-4-dihydroxystilbene-dhs-inhibits-human-neuroblastoma-tumor-growth-and-induces-mitochondrial-and-lysosomal-damages-in-neuroblastoma-cell-lines
#15
Bhaskar Saha, Birija Sankar Patro, Mrunesh Koli, Ganesh Pai, Jharna Ray, Sandip K Bandyopadhyay, Subrata Chattopadhyay
In view of the inadequacy of neuroblastoma treatment, five hydroxystilbenes and resveratrol (Resv) were screened for their cytotoxic property against human neuroblastoma cell lines. The mechanism of cytotoxic action of the most potent compound, trans-4,4'-dihydroxystilbene (DHS) was investigated in vitro using human neuroblastoma cell lines. DHS was also tested in a mouse xenograft model of human neuroblastoma tumor. The MTT, sub-G1, annexin V and clonogenic assays as well as microscopy established higher cytotoxicity of DHS than Resv to the IMR32 cell line...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28575580/evaluation-of-the-process-performance-of-a-down-flow-hanging-sponge-reactor-for-direct-treatment-of-domestic-wastewater-in-bangkok-thailand
#16
Yuma Miyaoka, Wilasinee Yoochatchaval, Haruhiko Sumino, Pathan Banjongproo, Takashi Yamaguchi, Takashi Onodera, Tomohiro Okadera, Kazuaki Syutsubo
This study assesses the performance of an aerobic trickling filter, down-flow hanging sponge (DHS) reactor, as a decentralized domestic wastewater treatment technology. Also, the characteristic eukaryotic community structure in DHS reactor was investigated. Long-term operation of a DHS reactor for direct treatment of domestic wastewater (COD = 150-170 mg/L and BOD = 60-90 mg/L) was performed under the average ambient temperature ranged from 28°C to 31°C in Bangkok, Thailand. Throughout the evaluation period of 550 days, the DHS reactor at a hydraulic retention time of 3 h showed better performance than the existing oxidation ditch process in the removal of organic carbon (COD removal rate = 80-83% and BOD removal rate = 91%), nitrogen compounds (total nitrogen removal rate = 45-51% and NH4(+)-N removal rate = 95-98%), and low excess sludge production (0...
June 2, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28571583/effect-of-user-preferences-on-itn-use-a-review-of-literature-and-data
#17
Hannah Koenker, Joshua O Yukich
BACKGROUND: Insecticide-treated bed nets (ITNs) are the primary tool for vector control, and optimizing ITN use is a key concern of national programmes. Available evidence indicates that bed net users often have preferences for shape, colour, size, and other attributes, but it is unclear whether these preferences are strong enough to have any significant effect on bed net use, and whether countries and donors should invest in more expensive attributes in order to maximize ITN use. The link between bed net attributes, preferences, and use was investigated using a literature review and review of publicly available, nationally representative household surveys from sub-Saharan Africa...
June 1, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28571221/a-comparative-study-of-the-dynamic-hip-screw-the-cemented-bipolar-hemiarthroplasty-and-the-proximal-femoral-nail-for-the-treatment-of-unstable-intertrochanteric-fractures
#18
Sameer Ajit Mansukhani, Sanesh Vijay Tuteja, Vaibhav B Kasodekar, Shyamlal R Mukhi
INTRODUCTION: Fractures of the Intertrochanteric (IT) region are some of the most common fractures encountered by an orthopedic surgeon in his lifetime. With increase in life expectancy, the incidence of these fractures is also increasing. By 2040, the incidence of these fractures is expected to double. Unstable IT fractures are a major cause of concern in the elderly due to the associated increase in morbidity and mortality. AIM: The purpose of this study was to compare the intraoperative and postoperative parameters using the Dynamic Hip Screw (DHS), the Cemented Bipolar Hemiarthroplasty (BH) and the Proximal Femoral Nail (PFN) for the management of unstable IT fractures...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28561138/skin-color-and-maternal-near-miss-exploring-a-demographic-and-health-survey-in-brazil
#19
Karayna Gil Fernandes, Maria Helena Sousa, José Guilherme Cecatti
Purpose In 2013, it was estimated that 289,000 maternal deaths occurred worldwide. The maternal mortality ratio has decreased in many countries in the past decades, due to early identification and treatment of obstetric complications, despite the dissimilarities observed in diverse locations and populations. Black women, for instance, have always been more susceptible to the occurrence of maternal mortality and severe morbidity. Therefore, the objective of this study is to assess skin color as a predictive factor for maternal near miss (MNM) in a sample of Brazilian women interviewed in the Brazilian National Demographic and Health Survey (DHS) of 2006...
May 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28542176/measuring-personal-beliefs-and-perceived-norms-about-intimate-partner-violence-population-based-survey-experiment-in-rural-uganda
#20
Alexander C Tsai, Bernard Kakuhikire, Jessica M Perkins, Dagmar Vořechovská, Amy Q McDonough, Elizabeth L Ogburn, Jordan M Downey, David R Bangsberg
BACKGROUND: Demographic and Health Surveys (DHS) conducted throughout sub-Saharan Africa indicate there is widespread acceptance of intimate partner violence, contributing to an adverse health risk environment for women. While qualitative studies suggest important limitations in the accuracy of the DHS methods used to elicit attitudes toward intimate partner violence, to date there has been little experimental evidence from sub-Saharan Africa that can be brought to bear on this issue...
May 2017: PLoS Medicine
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