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https://www.readbyqxmd.com/read/28937434/th17-response-of-borderline-lepromatous-leprosy-inhibits-rash-manifestation-of-dapsone-hypersensitivity-syndrome-case-report
#1
Tamara de Nardo Vanzela, Fred Bernardes Filho, Carlos Gustavo Wambier, Francesca Maia Faria, Norma Tiraboschi Foss, Marco Andrey Cipriani Frade
BACKGROUND: Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. OBJECTIVE: Evaluation of immunological factors involved in the sparing of borderline-lepromatous (BL) leprosy patches by the severe exanthema related to DHS. METHODS: The authors describe a 19-year-old man with borderline-lepromatous leprosy with a recent diffuse rash, sparing only the hypochromic patches of leprosy, generalized lymphadenopathy, hepatomegaly, and jaundice 25 days after the start of multibacillary multidrug therapy...
September 11, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28926961/effects-of-metal-ions-temperature-and-a-denaturant-on-the-oxidative-folding-pathways-of-bovine-%C3%AE-lactalbumin
#2
Reina Shinozaki, Michio Iwaoka
Bovine α-lactalbumin (αLA) has four disulfide (SS) bonds in the native form (N). On the oxidative folding pathways of this protein, two specific SS folding intermediates, i.e., (61-77, 73-91) and des[6-120], which have two and three native SS bonds, respectively, accumulate predominantly in the presence of Ca(2+). In this study, we reinvestigated the pathways using a water-soluble cyclic selenoxide reagent, trans-3,4-dihydroxyselenolane oxide (DHS(ox)), as a strong and quantitative oxidant to oxidize the fully reduced form (R)...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28890773/the-use-of-facilities-for-labor-and-delivery-the-views-of-women-in-rural-uganda
#3
Rebecca Newell, Ian Spillman, Marie-Louise Newell
The aim of the paper is to explore factors associated with home or hospital delivery in rural Uganda. Qualitative interviews with recently-delivered women in rural Uganda and statistical analysis of data from the 2011 Ugandan Demographic and Health Survey (DHS) to assess the association between socio-demographic and cultural factors and delivery location in multivariable regression models. In the DHS, 61.7% (of 4907) women had a facility-based delivery (FBD); in adjusted analyses, FBD was associated with an urban setting [adjusted odds ratio (aOR) 3...
June 23, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28883744/sexual-autonomy-and-contraceptive-use-among-women-in-nigeria-findings-from-the-demographic-and-health-survey-data
#4
Saritha P Viswan, T K Sundari Ravindran, Ngianga-Bakwin Kandala, Max G Petzold, Sharon Fonn
CONTEXT: The persistent low contraceptive use and high fertility in Nigeria despite improvements in educational achievements calls for an examination of the role of factors, which may moderate the use of modern contraception. This article explores the influence of sexual autonomy on the use of modern contraceptive methods among women and its relative importance compared with other, more traditional, indicators of women's autonomy such as education and occupation. DATA AND METHODS: Data from two Demographic and Health Surveys (DHS), 2008 and 2013, were used in this study...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28878427/mortality-and-disability-adjusted-life-years-dalys-for-common-neglected-tropical-diseases-in-ethiopia-1990-2015-evidence-from-the-global-burden-of-disease-study-2015
#5
A Deribew, B Kebede, G A Tessema, Y A Adama, A Misganaw, T Gebre, A Hailu, S Biadgilign, A Amberbir, B Desalegn, A A Abajobir, O Shafi, S F Abera, N Negussu, B Mengistu, A T Amare, A Mulugeta, Z Kebede, B Mengistu, Z Tadesse, M Sileshi, M Tamiru, E A Chromwel, S D Glenn, J D Stanaway, K Deribe
INTRODUCTION: Neglected tropical diseases (NTDs) are important public health problems in Ethiopia. In 2013, the Federal Ministry of Health (FMOH) has launched a national NTD master plan to eliminate major NTDs of public health importance by 2020. Benchmarking the current status of NTDs in the country is important to monitor and evaluate the progress in the implementation of interventions and their impacts. Therefore, this study aims to assess the trends of mortality and Disability-adjusted Life-Years (DALY) for the priority NTDs over the last 25 years...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28870516/a-docking-model-of-dapsone-bound-to-hla-b-13-01-explains-the-risk-of-dapsone-hypersensitivity-syndrome
#6
Hideaki Watanabe, Yurie Watanabe, Yasuya Tashiro, Taisei Mushiroda, Takeshi Ozeki, Hideo Hashizume, Hirohiko Sueki, Toshinori Yamamoto, Naoko Utsunomiya-Tate, Hiroaki Gouda, Yoshio Kusakabe
BACKGROUND: Dapsone (4,4'-diaminodiphenylsulfone) has been widely used for the treatment of infections such as leprosy. Dapsone hypersensitivity syndrome (DHS) is a major side effect, developing in 0.5-3.6% of patients treated with dapsone, and its mortality rate is ∼10%. Recently, human leukocyte antigen (HLA)-B*13:01 was identified as a marker of susceptibility to DHS. OBJECTIVES: To investigate why HLA-B*13:01 is responsible for DHS from a structural point of view...
August 24, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28854785/direct-contact-sorptive-extraction-a-robust-method-for-sampling-plant-volatiles-in-the-field
#7
Nicole Kfoury, Eric Scott, Colin Orians, Albert Robbat
Plants produce volatile organic compounds (VOCs) with diverse structures and functions, which change in response to environmental stimuli and have important consequences for interactions with other organisms. To understand these changes, in situ sampling is necessary. In contrast to dynamic headspace (DHS), which is the most often employed method, direct contact sampling employing a magnetic stir bar held in place by a magnet eliminates artifacts produced by enclosing plant materials in glass or plastic chambers...
September 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28844681/dynamic-hip-system-blade-versus-cannulated-compression-screw-for-the-treatment-of-femoral-neck-fractures-a-retrospective-study
#8
Chao Chen, Li Yu, Xin Tang, Mo-Zhen Liu, Li-Zhong Sun, Changjian Liu, Zhen Zhang, Chang-Zhou Li
OBJECTIVE: The aim of this study was to compare clinical outcomes of patients with femoral neck fractures treated with the dynamic hip system blade (DHS-BLADE) or cannulated compression screws. METHODS: Eighty-six patients with femoral neck fractures were treated by closed reduction internal fixation with a DHS-BLADE (n = 42; 18 males and 24 females; mean age: 56.3 years (37-87)) or cannulated compression screws (n = 44; 20 males and 24 females; mean age: 53...
August 24, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28841091/persistent-inequity-in-maternal-health-care-utilization-in-nepal-despite-impressive-overall-gains
#9
Mats Målqvist, Asha Pun, Hendrikus Raaijmakers, Ashish Kc
BACKGROUND: Maternal health care utilization is at the core of global public health provision and an area of focus in the now-concluded Millennium Development Goal agenda. OBJECTIVE: This study aims to examine trends in maternal health care utilization over the last 15 years in Nepal, focusing on coverage and equity. METHODS: This paper used data from the Demographic Health Survey (DHS) 2001, 2006 and 2011 and Multiple Indicator Cluster Survey (MICS), 2014...
2017: Global Health Action
https://www.readbyqxmd.com/read/28837274/association-between-bone-mineral-density-and-depressive-symptoms-in-a-population-based-sample
#10
Rocco D Hlis, Roger S McIntyre, Naim M Maalouf, Erin Van Enkevort, E Sherwood Brown
OBJECTIVE: This analysis was conducted to determine the relationship between bone mineral density (BMD) and depressive symptoms in a population-based cohort. METHODS: Data were extracted from the second phase of the Dallas Heart Study (DHS-2), a large, multiethnic population sample in Dallas County, Texas, from September 1, 2007, to December 31, 2009. Depressive symptom severity was measured with the 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR₁₆), which is derived from DSM-IV major depressive disorder criteria...
August 22, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28834954/low-varicella-zoster-virus-seroprevalence-among-young-children-in-the-democratic-republic-of-the-congo
#11
Reena H Doshi, Vivian H Alfonso, Patrick Mukadi, Nicole A Hoff, Sue Gerber, Ado Bwaka, Stephen G Higgins, Brian Cowell, Guillaume Ngoie Mwamba, Emile Okitolonda, Jean-Jacques Muyembe-Tamfum, Anne W Rimoin
BACKGROUND: Varicella zoster virus (VZV) causes both varicella (chickenpox) and herpes zoster (shingles) and is associated with significant global morbidity. Most epidemiological data on VZV come from high-come countries and to date there are limited data on the burden of VZV in Africa. METHODS: We assessed the seroprevalence of VZV antibodies among children in the Democratic Republic of Congo in collaboration with the 2013-2014 Demographic and Health Survey (DHS)...
August 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28826251/prevalence-of-iron-deficiency-and-iron-deficiency-anemia-in-the-northern-and-southern-provinces-of-rwanda
#12
Moira Donahue Angel, Peter Berti, Kendra Siekmans, Pierrot Lundimu Tugirimana, Erick Boy
BACKGROUND: Anemia remains a public health problem in Rwanda, affecting 38% of young children and 17% of reproductive-aged women (Demographic and Health Survey [DHS] 2010). The importance of iron deficiency (ID) as a cause of anemia in Rwanda is not known. OBJECTIVE: We aimed to estimate the prevalence of ID and iron deficiency anemia (IDA) among young children and women in 2 provinces of Rwanda. METHODS: We conducted a cluster randomized survey, selecting 408 rural households each in the Northern and Southern Provinces of Rwanda in 2010...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28819816/a-new-non-radioactive-deoxyhypusine-synthase-assay-adaptable-to-high-throughput-screening
#13
Myung Hee Park, Ajeet Mandal, Swati Mandal, Edith C Wolff
Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N (ε) -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N (ε) -4-amino-2-hydroxybutyl(lysine)]. Hypusine synthesis represents the most critical function of polyamine. As eIF5A has been implicated in various human diseases, identification of specific inhibitors of hypusine modification is of vital importance...
August 17, 2017: Amino Acids
https://www.readbyqxmd.com/read/28812805/changes-in-socio-economic-inequality-in-neonatal-mortality-in-iran-between-1995-2000-and-2005-2010-an-oaxaca-decomposition-analysis
#14
Mostafa Amini Rarani, Arash Rashidian, Ardeshir Khosravi, Mohammad Arab, Ezatollah Abbasian, Esmaeil Khedmati Morasae
BACKGROUND: Exploring changes in health inequality and its determinants over time is of policy interest. Accordingly, this study aimed to decompose inequality in neonatal mortality into its contributing factors and then explore changes from 1995-2000 to 2005-2010 in Iran. METHODS: Required data were drawn from two Iran's demographic and health survey (DHS) conducted in 2000 and 2010. Normalized concentration index (CI) was used to measure the magnitude of inequality in neonatal mortality...
September 24, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28809084/practice-characteristics-and-service-provision-rates-of-dental-hygienists-in-australia
#15
N Amarasena, D N Teusner, D S Brennan, J Satur
INTRODUCTION: Dental hygienists (DHs) have been practising in Australia since the early 1970s. OBJECTIVE: This study describes the clinical activity of Australian DHs. METHODS: A questionnaire was mailed to members of two professional associations representing DHs. Practitioner characteristics, employment characteristics and clinical activity on a self-reported typical practice day were collected. The proportion of each service item of all services provided was estimated...
August 14, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28802822/stillbirth-prevalence-in-brazil-an-exploration-of-regional-differences
#16
Taiana Silva Carvalho, Pat Doyle, Lucia Campos Pellanda
INTRODUCTION: Brazil is a large, heterogeneous, and diverse country, marked by social, economic, and regional inequalities. Stillbirth is a global concern, especially in low- and middle-income countries. This study investigated the prevalence and possible determinants of stillbirth in different regions of Brazil. METHODS: This is a cross-sectional study including all women of reproductive age who had had a pregnancy in the last five years, enrolled in the most recent Brazilian Demographic and Health Survey (DHS/PNDS-2006/07)...
August 9, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28802425/outcomes-of-dynamic-hip-screw-augmented-with-trochanteric-wiring-for-treatment-of-unstable-type-a2-intertrochanteric-femur-fractures
#17
Chetan Puram, Chetan Pradhan, Atul Patil, Vivek Sodhai, Parag Sancheti, Ashok Shyam
BACKGROUND: Posteromedial and greater trochanteric fragments are a major cause of telescoping and medialization of the femoral shaft in an unstable intertrochanteric fracture. This leads to significant limb shortening, fracture collapse in varus position and implant failure, which can be prevented by trochanteric wiring in addition to dynamic hip screw (DHS) fixation. The purpose of our study is to assess the outcomes of DHS augmented with trochanteric wiring in unstable type A2 intertrochanteric fractures...
August 2017: Injury
https://www.readbyqxmd.com/read/28802420/dhs-osteosynthesis-with-internal-bone-grafting-in-unstable-delayed-presented-intracapsular-neck-femur-fractures
#18
Wasudeo M Gadegone, R M Chandak, Vijayanand R Lokhande
OBJECTIVES: The aim of this study was to assess fracture union and complications following use of dynamic hip screw (DHS) with internal bone grafting in treatment of unstable delayed presented intracapsular neck femur fractures in patients younger than 65 years of age. MATERIAL AND METHODS: Thirty two patients with displaced intracapsular neck femur fractures(Garden III and IV, Pauwels III, with comminution) with delayed presentation (15-60 days) in the 45-65 year age group (mean 54...
August 2017: Injury
https://www.readbyqxmd.com/read/28802416/accuracy-of-valgus-osteotomy-using-dynamic-hip-screw
#19
Sunil G Kulkarni, G S Kulkarni, Sushrut Babhulkar, Milind G Kulkarni, Ruta M Kulkarni
BACKGROUND: Non-union of neck femur is a common but difficult situation to manage especially in young adults. There are two main options of arthroplasty or osteotomy. The aim of this study was to assess the results of intertrochanteric valgus osteotomy in non-union femoral neck fractures. PATIENTS AND METHODS: We present a study of 44 cases of neck femur non-union including untreated fractures, late presentations (more than 3 weeks), treated with compression screw, DHS...
August 2017: Injury
https://www.readbyqxmd.com/read/28795311/the-rise-of-female-sterilization-a-closer-look-at-colombia
#20
Beatriz M Folch, Sarah Betstadt, Dongmei Li, Natalie Whaley
Objective In the 1970s, OCPs and IUDs were the most popular contraceptive methods in Colombia. According to data from the most recent Demographic and Health Survey (DHS), sterilization has become the most common form of birth control in Colombia. This study aims to examine the characteristics of Colombian women desiring long-acting contraception. Methods This study uses the 2005 and 2010 Colombian DHS dataset. Women who choose long-acting contraception were divided into those using female sterilization and those using long-acting reversible contraception (LARC)...
August 9, 2017: Maternal and Child Health Journal
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