Ying Chen, Ming-Fei Wu, Man-Man Xie, Yang Lu, Chao Li, Shuai-Shuai Xie, Wen-Xian Ma, Ming-Lu Ji, Rui Hou, Ze-Hui Dong, Ruo-Bing He, Meng-Meng Zhang, Hao Lu, Li Gao, Jia-Gen Wen, Juan Jin, Xiao-Wu Dong, Jin-Xin Che, Xiao-Ming Meng
Acute kidney injury (AKI) is defined as sudden loss of renal function characterized by increased serum creatinine levels and reduced urinary output with a duration of 7 days. Ferroptosis, an iron-dependent regulated necrotic pathway, has been implicated in the progression of AKI, while ferrostatin-1 (Fer-1), a selective inhibitor of ferroptosis, inhibited renal damage, oxidative stress and tubular cell death in AKI mouse models. However, the clinical translation of Fer-1 is limited due to its lack of efficacy and metabolic instability...
April 19, 2024: Acta Pharmacologica Sinica