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closed circuit anesthesia

Leonardo C Faria, Feng Gu, Isabel Parada, Ben Barres, Z David Luo, David A Prince
The alpha2delta-1 subunit (α2δ-1) of voltage-gated calcium channels is a receptor for astrocyte-secreted thrombospondins that promote developmental synaptogenesis. Alpha2delta-1 receptors are upregulated in models of injury-induced peripheral pain and epileptogenic neocortical trauma associated with an enhancement of excitatory synaptic connectivity. These results lead to the hypothesis that overexpression of α2δ-1 alone in neocortex of uninjured transgenic (TG) mice might result in increased excitatory connectivity and consequent cortical hyperexcitability and epileptiform activity...
June 2017: Neurobiology of Disease
Tatsuo Igarashi, Takuro Ishii, Tomohiko Aoe, Wen-Wei Yu, Yuma Ebihara, Hiroshi Kawahira, Shiro Isono, Yukio Naya
BACKGROUND: Laparoscopic and robot-assisted surgeries are performed under carbon dioxide insufflation. Switching from gas to an isotonic irrigant introduces several benefits and avoids some adverse effects of gas insufflation. We developed an irrigating device and apparatus designed for single-incision laparoscopic surgery and tested its advantages and drawbacks during surgery in a porcine model. MATERIALS AND METHODS: Six pigs underwent surgical procedures under general anesthesia...
February 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Timur Özelsel, Seok Hee Kim, Saifee Rashiq, Ban C H Tsui
No abstract text is available yet for this article.
December 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Sung-Wook Park, Jun-Young Chung, Eun-Jin Moon, Young-Jin Kang, Jong-Man Kang
BACKGROUND: The aim of this study was to determine whether the end-tidal concentration of desflurane would be affected by a breathing circuit system filter attached at two different positions in anesthetic breathing circuit systems. METHODS: An artificial lung was ventilated under five different conditions. The first group was without any filter or desflurane (n = 5, sham), the second was with desflurane but without any filter (n = 10, control), the third group had a bacterial filter on the expiratory limb (n = 10), and the fourth and fifth groups had a viral/bacterial filter added on the expiratory limb (n = 10) or at the Y-piece of the breathing circuit (n = 10), respectively...
August 2015: Korean Journal of Anesthesiology
Rik Carette, Andre M De Wolf, Jan F A Hendrickx
The FLOW-i anesthesia machine (Maquet, Solna, Sweden) can be equipped with automated gas control (AGC), an automated low flow tool with target control of the inspired oxygen concentration (FIO2) and end-expired concentration (FA) of a potent inhaled anesthetic. We examined the performance and quantitative aspects of the AGC. After IRB approval and individual informed consent, anesthesia in 24 ASA I-II patients undergoing abdominal or gynecological surgery was maintained with sevoflurane in O2/air with a target FIO2 of 40 % and a target sevoflurane FA (FAsevo) of 2...
June 2016: Journal of Clinical Monitoring and Computing
Ivana Jurickova, Karel Roubík, Martin Muller
BACKGROUND: Heliox is a mixture of oxygen and helium which reduces airway resistance in patients with airway obstruction. In clinical practice, patients breathing spontaneously receive heliox via an open circuit. Recently, a semi-closed circuit for heliox administration has been proposed which minimizes consumption of heliox and therefore cost of the heliox therapy; although, the semi-closed circuit is associated with additional costs. The aim of the study is to conduct an economical analysis comparing total cost of heliox therapy using an open versus a semi-closed circuit in spontaneously breathing patients with airway obstruction...
2015: BMC Pulmonary Medicine
Michael O Ayeko, Ahmed A M Hesham, Mohan Gyanendra
No abstract text is available yet for this article.
November 2014: Saudi Journal of Anaesthesia
Sofie De Cooman, Jan F A Hendrickx, Philip John Peyton, Jean-Luc Demeere, Andre M De Wolf
BACKGROUND: Earlier software versions of the Zeus® (Lübeck, Dräger, Germany) failed to provide true closed circuit anesthesia (CCA) conditions. We examined whether the latest software (SW 4.03 MK 04672-00) achieves this goal. METHODS: In 8 ASA I-III patients, the CCA mode of the Zeus® was used to maintain the inspired O2 (FIO2) and end-expired sevoflurane % (FAsevo) at 50 and 1.8%, respectively. The fresh gas flow (FGF) of O2 and air and the sevoflurane injection rate (=Vinjsevo, mL liquid sevo/h) were videotaped from the control screen and entered offline into a spreadsheet...
2014: BMC Research Notes
Jorge Ronaldo Moll, Joaquim Edson Vieira, Judymara Lauzi Gozzani, Lígia Andrade Silva Telles Mathias
BACKGROUND AND OBJECTIVES: Few investigations have addressed the safety of oxygen from concentrators for use in anesthesia in association with nitrous oxide. This study evaluated the percent of oxygen from a concentrator in association with nitrous oxide in a semi-closed rebreathing circuit. METHODS: Adult patients undergoing low risk surgery were randomly allocated into two groups, receiving a fresh gas flow of oxygen from concentrators (O293) or of oxygen from concentrators and nitrous oxide (O293N2O)...
May 2014: Brazilian Journal of Anesthesiology
No abstract text is available yet for this article.
June 1950: Anesthésie et Analgésie
No abstract text is available yet for this article.
June 1950: Anesthésie et Analgésie
A V Rylova, A Iu Beliaev, A Iu Lubnin
Among anesthetic agents used in neurosurgery xenon appears to be the most advantageous. It preserves arterial blood pressure, assures rapid recovery and neuroprotection. But the data is lacking on xenon effect upon cerebral blood flow under anesthetic conditions. We measured flow velocity in middle cerebral artery in neurosurgical patients without intracranial hypertension during closed circuit xenon anesthesia comparing propofol and xenon effect in the same patients. In our study xenon didn't seem to induce clinically relevant changes in cerebral blood flow and preserved cerebral vascular reactivity thus proving its safety in patients without intracranial hypertension...
July 2013: Anesteziologiia i Reanimatologiia
S Parthasarathy
A breathing system is defined as an assembly of components, which delivers gases from the anesthesia machine to the patients' airways. When the components are arranged as a circle, it is termed a circle system. The flow of exhaled gases is unidirectional in the system. The system contains a component (absorber), which absorbs exhaled carbon dioxide and it is not necessary to give high fresh gas flows as in Mapleson systems. When the adjustable pressure limiting (APL) valve is closed and all the exhaled gases without carbon dioxide are returned to the patient, the system becomes a totally closed one...
September 2013: Indian Journal of Anaesthesia
Miguel Valencia, Mario Chavez, Julio Artieda, J Paul Bolam, Juan Mena-Segovia
The activity of the basal ganglia is altered in Parkinson's disease (PD) as a consequence of the degeneration of dopamine neurons in the substantia nigra pars compacta. This results in aberrant discharge patterns and expression of exaggerated oscillatory activity across the basal ganglia circuit. Altered activity has also been reported in some of the targets of the basal ganglia, including the pedunculopontine nucleus (PPN), possibly due to its close interconnectivity with most regions of the basal ganglia...
January 2014: Journal of Neurophysiology
Marianna Bacellar, Janice Querubin, Simon M Petersen-Jones
PURPOSE: The purpose of this study is to report a method for making a cheap and effective anesthesia facemask for laboratory rodents and chicks that allows access to the eyes for ophthalmic procedures such as electroretinography (ERG) and optical coherence tomography (OCT). METHODS: The facemask is fabricated from a bulb syringe and a medicine dropper (Luvs(®) , Jamaica, NY) both intended for use in infants. The tip of the bulb syringe is removed to make a plastic cone (1...
July 2013: Veterinary Ophthalmology
Jennifer L Collins, Xinqi Peng, Robyn Lee, Alicia Witriol, Zdenka Pierre, Alfred M Sciuto
Nerve agents pose a threat to the respiratory tract with exposure that could result in acute compromised lung performance and death. The determination of toxicity by inhalation is important for the rational development of timely therapeutic countermeasures. This study was designed to deliver aerosolized dilute nerve agents in a dose-response manner to investigate the extent of lethality of nerve agents: soman, sarin, VX and VR. Male rats (240-270 g) were anesthetized intramuscularly with 10 mg/kg xylazine and 90 mg/kg ketamine...
February 2013: Toxicology Mechanisms and Methods
Joseph Rinehart, Elena Chung, Cecilia Canales, Maxime Cannesson
OBJECTIVE: The authors compared the performance of a group of anesthesia providers to closed-loop (Learning Intravenous Resuscitator [LIR]) management in a simulated hemorrhage scenario using cardiac output monitoring. DESIGN: A prospective cohort study. SETTING: In silico simulation. PARTICIPANTS: University hospital anesthesiologists and the LIR closed-loop fluid administration system. INTERVENTIONS: Using a patient simulator, a 90-minute simulated hemorrhage protocol was run, which included a 1,200-mL blood loss over 30 minutes...
October 2012: Journal of Cardiothoracic and Vascular Anesthesia
Metha Brattwall, Margareta Warrén-Stomberg, Fredrik Hesselvik, Jan Jakobsson
PURPOSE: The aim of this brief review is to provide an update on the theory regarding minimal fresh gas flow techniques for inhaled general anesthesia. The article also includes an update and discussion of the practical aspects associated with minimal-flow anesthesia, including the advantages, potential limitations, and safety considerations of this important anesthetic technique. PRINCIPAL FINDINGS: Reducing the fresh gas flow to < 1 L·min(-1) during maintenance of anesthesia is associated with several benefits...
August 2012: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Karel Roubík, Roman Zazula, Adéla Strnadová, Vladimír Zábrodský, Antonín Spálený, Martin Müller, Jan Chlumský, Tomáš Tyll
INTRODUCTION: The use of helium-oxygen mixture (heliox) for ventilation has an advantage in patients with obstruction of the airways. The physical properties of helium enable an easier gas flow through the airways; this enables easier breathing for the patient when compared to standard ventilation of air. A high cost of heliox falls within the factors that limit the use of heliox in clinical practice. At present, heliox is administered by use of an open circuit. The aim of this study is to propose a way of heliox administration that reduces heliox consumption but does not affect the positive heliox effects upon the airway resistance...
June 2012: International Journal of Artificial Organs
Jeffrey M Feldman
Anesthetic drugs have the potential to contribute to global warming. There is some debate about the overall impact of anesthetic drugs relative to carbon dioxide, but there is no question that practice patterns can limit the degree of environmental contamination. In particular, careful attention to managing fresh gas flow can use anesthetic drugs more efficiently--reducing waste while achieving the same effect on the patient. The environmental impact of a single case may be minimal, but when compounded over an entire career, the manner in which fresh gas flow is managed by each individual practitioner can make a significant difference in the volume of anesthetic gases released into the atmosphere...
May 2012: Anesthesia and Analgesia
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