keyword
https://read.qxmd.com/read/38437201/mousepzt-a-simple-reliable-low-cost-device-for-vital-sign-monitoring-and-respiratory-gating-in-mice-under-anesthesia
#1
JOURNAL ARTICLE
Daniel A Rivera, Anne E Buglione, Sadie E Ray, Chris B Schaffer
Small animal studies in biomedical research often require anesthesia to reduce pain or stress experienced by research animals and to minimize motion artifact during imaging or other measurements. Anesthetized animals must be closely monitored for the safety of the animals and to prevent unintended effects of altered physiology on experimental outcomes. Many currently available monitoring devices are expensive, invasive, or interfere with experimental design. Here, we present MousePZT, a low-cost device based on a simple piezoelectric sensor, with a custom circuit and computer software that allows for measurements of both respiratory rate and heart rate in a non-invasive, minimal contact manner...
2024: PloS One
https://read.qxmd.com/read/38328136/propofol-disrupts-the-functional-core-matrix-architecture-of-the-thalamus-in-humans
#2
Zirui Huang, George A Mashour, Anthony G Hudetz
Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either the thalamus as a whole or focused on specific subregions, overlooking the distinct neuronal subtypes like core and matrix cells. We conducted a study of heathy volunteers and functional magnetic resonance imaging during conscious baseline, deep sedation, and recovery. We advanced the functional gradient mapping technique to delineate the functional geometry of thalamocortical circuits, within a framework of the unimodal-transmodal functional axis of the cortex...
January 24, 2024: bioRxiv
https://read.qxmd.com/read/38310593/the-10%C3%A2-hz-dynamic-response-of-a-fluid-filled-pressure-monitoring-system-is-a-novel-alternative-to-the-fast-flush-test-and-indicative-of-unacceptable-systolic-pressure-overshoot
#3
JOURNAL ARTICLE
Tomoki Hirahata, Shuichi Hashimoto, Hiroaki Watanabe, Shin-Ichi Yagi, Mitsutaka Edanaga, Michiaki Yamakage
The standard method for qualitatively evaluating the dynamic response is to see if the gain of the amplitude spectrum curve approaches 1 (input signal = output signal) over the frequency band of the blood pressure waveform. In a previous report, Watanabe reported that Gardner's natural frequency and damping coefficient, which are widely used as evaluation methods, do not reflect the dynamic response of the circuit. Therefore, new parameters for evaluating the dynamic response of pressure monitoring circuits were desired...
February 4, 2024: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/38168365/developmentally-unique-cerebellar-processing-prioritizes-self-over-other-generated-movements
#4
Angela M Richardson, Greta Sokoloff, Mark S Blumberg
UNLABELLED: To compute internal models of movement, the cerebellum must distinguish sensory input arising from self- and other-generated movements (reafference and exafference, respectively). This distinction is enabled by copies of motor commands (i.e., corollary discharges) that are sent to the cerebellum. The capacity to compute internal models emerges gradually through a process that is not yet understood. Previously, we demonstrated in 8-day-old (P8) rats that precerebellar nuclei-including the inferior olive and lateral reticular nucleus-convey corollary discharge and reafference to the cerebellum during active (REM) sleep when pups produce self-generated limb twitches...
December 16, 2023: bioRxiv
https://read.qxmd.com/read/38166574/major-pneumothorax-during-pediatric-cardiac-mri-procedure-under-general-anesthesia-step-by-step-analysis-and-importance-of-a-well-known-environment-and-material
#5
JOURNAL ARTICLE
Quentin Delhez, Laurent Bairy, John Mitchell, Adrien Maseri
BACKGROUND: To perform step-by-step analysis of the different factors (material, anesthesia technique, human, and location) that led to major pneumothorax during an infrequent pediatric cardiac MRI and to prevent its occurrence in the future. Anesthesia equipment used in a remote location is often different than those in operating rooms. For magnetic resonance imaging (MRI), ventilation devices and monitors must be compatible with the magnetic fields. During cardiac MRI numerous apneas are required and, visual contact with the patient is limited for clinical evaluation...
January 2, 2024: BMC Anesthesiology
https://read.qxmd.com/read/37639312/erratum-rat-model-of-normothermic-ex-situ-perfused-heterotopic-heart-transplantation
#6
JOURNAL ARTICLE
(no author information available yet)
An erratum was issued for: Rat Model of Normothermic Ex-Situ Perfused Heterotopic Heart Transplantation. The Protocol section was updated. Section 4 of the Protocol was updated from: 4. Implantation Preparation of recipient Begin the recipient preparation 30 min before the cessation of ex situ perfusion. Anesthetize the recipient animal using the same method as mentioned in step 2.2. Place the rat in a supine position on the heating pad and insert the temperature probe into the rectum to maintain the body temperature at 37 °C...
August 28, 2023: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/37497434/a-large-arteriovenous-fistula-steals-a-considerable-part-of-systemic-blood-flow-during-veno-arterial-extracorporeal-circulation-support-in-a-porcine-model
#7
JOURNAL ARTICLE
A Valerianova, M Mlcek, O Kittnar, T Grus, L Tejkl, V Lejsek, J Malik
Background: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is one of the most frequently used mechanical circulatory support devices. Distribution of extracorporeal membrane oxygenation flow depends (similarly as the cardiac output distribution) on regional vascular resistance. Arteriovenous fistulas (AVFs), used frequently as hemodialysis access, represent a low-resistant circuit which steals part of the systemic perfusion. We tested the hypothesis that the presence of a large Arteriovenous fistulas significantly changes organ perfusion during a partial and a full Veno-arterial extracorporeal membrane oxygenation support...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37465699/comparing-the-hemodynamic-effect-of-a-large-arteriovenous-fistula-during-high-and-low-cardiac-output-states
#8
JOURNAL ARTICLE
A Valerianova, M Mlcek, J Malik, T Grus, L Tejkl, B Kolosova, V Lejsek, O Kittnar
Background: A large arteriovenous fistula (AVF) is a low-resistant circuit that affects organ perfusion and systemic hemodynamics even in standard conditions. The extent of its' effect in critical states has not been elucidated yet. We used norepinephrine to create systemic vasoconstriction, dobutamine to create high cardiac output, and rapid right ventricle pacing as a model of acute heart failure in a porcine model of high-flow AVF circulation. Methods: The protocol was performed on nine domestic female pigs under general anesthesia...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37358290/porcine-normothermic-isolated-liver-perfusion
#9
JOURNAL ARTICLE
Joris Blondeel, Nicholas Gilbo, Tine Wylin, Veerle Heedfeld, Diethard Monbaliu
Porcine models of liver ex situ normothermic machine perfusion (NMP) are increasingly being used in transplant research. Contrary to rodents, porcine livers are anatomically and physiologically close to humans, with similar organ size and bile composition. NMP preserves the liver graft at near-to-physiological conditions by recirculating a warm, oxygenated, and nutrient-enriched red blood cell-based perfusate through the liver vasculature. NMP can be used to study ischemia-reperfusion injury, preserve a liver ex situ before transplantation, assess the liver's function prior to implantation, and provide a platform for organ repair and regeneration...
June 9, 2023: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/37166694/behaviour-and-stability-of-thermodilution-signals-in-a-closed-extracorporeal-circuit-a-bench-study
#10
JOURNAL ARTICLE
Elia J Stanger, David C Berger, Hansjörg Jenni, Kaspar F Bachmann
Thermodilution is the gold standard for cardiac output measurement in critically ill patients. Its application in extracorporeal therapy is limited, as a portion of the thermal indicator is drawn into the extracorporeal circuit. The behaviour of thermodilution signals in extracorporeal circuits is unknown. We investigated thermodilution curves within a closed-circuit and assessed the impact of injection volume, flow and distance on the behaviour of the thermodilution signals and catheter constants. We injected 3, 5, 7 and 10 ml of thermal indicator into a heated closed circuit...
May 11, 2023: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/36317426/general-anesthesia-and-sleep-like-and-unlike
#11
REVIEW
Jieun Jung, Tae Kim
General anesthesia and sleep have long been discussed in the neurobiological context owing to their commonalities, such as unconsciousness, immobility, non-responsiveness to external stimuli, and lack of memory upon returning to consciousness. Sleep is regulated by complex interactions between wake-promoting and sleep-promoting neural circuits. Anesthetics exert their effects partly by inhibiting wake-promoting neurons or activating sleep-promoting neurons. Unconscious but arousable sedation is more related to sleep-wake circuitries, whereas unconscious and unarousable anesthesia is independent of them...
October 2022: Anesthesia and pain medicine
https://read.qxmd.com/read/36102998/translational-design-for-limited-resource-settings-as-demonstrated-by-vent-lock-a-3d-printed-ventilator-multiplexer
#12
JOURNAL ARTICLE
Helen Xun, Christopher Shallal, Justin Unger, Runhan Tao, Alberto Torres, Michael Vladimirov, Jenna Frye, Mohit Singhala, Brockett Horne, Bo Soo Kim, Broc Burke, Michael Montana, Michael Talcott, Bradford Winters, Margaret Frisella, Bradley S Kushner, Justin M Sacks, James K Guest, Sung Hoon Kang, Julie Caffrey
BACKGROUND: Mechanical ventilators are essential to patients who become critically ill with acute respiratory distress syndrome (ARDS), and shortages have been reported due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: We utilized 3D printing (3DP) technology to rapidly prototype and test critical components for a novel ventilator multiplexer system, Vent-Lock, to split one ventilator or anesthesia gas machine between two patients...
September 14, 2022: 3D Printing in Medicine
https://read.qxmd.com/read/35103886/memsorb%C3%A2-a-novel-co-2-removal-device-part-ii-in-vivo-performance-with-the-zeus-ie-%C3%A2
#13
JOURNAL ARTICLE
Sarah A Eerlings, Mohammed K Bashraheel, Andre M De Wolf, Arne Neyrinck, Marc Van de Velde, Geert Vandenbroucke, Rik Carette, Jeffrey Feldman, Jan F A Hendrickx
Memsorb™ (DMF Medical, Halifax, Canada) is a novel device based upon membrane oxygenator technology designed to eliminate CO2 from exhaled gas when using a circle anesthesia circuit. Exhaled gases pass through semipermeable hollow fibers and sweep gas flowing through these fibers creates a diffusion gradient for CO2 removal. In vivo Memsorb™ performance was tested during target-controlled closed-circuit anesthesia (TCCCA) with desflurane in O2 /air using a Zeus IE® anesthesia workstation (Dräger, Lübeck, Germany)...
February 1, 2022: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/35089526/memsorb%C3%A2-a-novel-co-2-removal-device-part-i-in-vitro-performance-with-the-zeus-ie%C3%A2
#14
JOURNAL ARTICLE
Mohammed K Bashraheel, Sarah A Eerlings, Andre M De Wolf, Arne Neyrinck, Marc Van de Velde, Geert Vandenbroucke, Rik Carette, Jeffrey Feldman, Jan F A Hendrickx
Soda lime-based CO2 absorbents are safe, but not ideal for reasons of ecology, economy, and dust formation. The Memsorb™ is a novel CO2 removal device that uses cardiopulmonary bypass oxygenator technology instead: a sweep gas passes through semipermeable hollow fibers, adding or removing gas from the circle breathing system. We studied the in vitro performance of a prototype Memsorb™ used with a Zeus IE® anesthesia machine when administering sevoflurane and desflurane in O2 /air mixtures. The Zeus IE® equipped with Memsorb™ ventilated a 2L breathing bag with a CO2 inflow port in its tip...
January 28, 2022: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/34903173/preparation-of-dr%C3%A3-ger-atlan-a350-and-general-electric-healthcare-carestation-650-anesthesia-workstations-for-malignant-hyperthermia-susceptible-patients
#15
JOURNAL ARTICLE
Sebastian Heiderich, Christian Thoben, Nils Dennhardt, Terence Krauß, Robert Sümpelmann, Stefan Zimmermann, Michael Reitz, Henrik Rüffert
BACKGROUND: Patients at risk of malignant hyperthermia need trigger-free anesthesia. Therefore, anesthesia machines prepared for safe use in predisposed patients should be free of volatile anesthetics. The washout time depends on the composition of rubber and plastic in the anesthesia machine. Therefore, new anesthesia machines should be evaluated regarding the safe preparation for trigger-free anesthesia. This study investigates wash out procedures of volatile anesthetics for two new anesthetic workstations: Dräger Atlan A350 and General Electric Healthcare (GE) Carestation 650 and compare it with preparation using activated charcoal filters (ACF)...
December 13, 2021: BMC Anesthesiology
https://read.qxmd.com/read/34056116/underwater-anesthesia-machines-well-almost-closed-circuit-rebreathers-and-the-leap-forward-for-advanced-diving-exploration-and-discovery
#16
JOURNAL ARTICLE
Christopher S Henson, Andrew D Pitkin, Derek B Covington
No abstract text is available yet for this article.
July 2020: Romanian Journal of Anaesthesia and Intensive Care
https://read.qxmd.com/read/33832426/electroencephalographic-dynamics-of-etomidate-induced-loss-of-consciousness
#17
JOURNAL ARTICLE
Lei Zhang, Shunqin Fan, Jiawei Zhang, Kun Fang, Lei Wang, Yuanyuan Cao, Lijian Chen, Xuesheng Liu, Erwei Gu
BACKGROUND: Highly structured electroencephalography (EEG) oscillations can occur in adults during etomidate-induced general anesthesia, but the link between these two phenomena is poorly understood. Therefore, in the present study, we investigated the electroencephalogram dynamics of etomidate-induced loss of consciousness (LOC) in order to understand the neurological mechanism of etomidate-induced LOC. METHODS: This study is a prospective observational study. Etomidate-induced anesthesia was performed on eligible patients undergoing elective surgery...
April 8, 2021: BMC Anesthesiology
https://read.qxmd.com/read/33591420/-commercial-soda-lime-ingestion-during-a-dive
#18
REVIEW
Mark Michael, Noemi Freise, Verena Keitel, Andreas Schaper, Christian Plettenberg, Sven Dreyer, Michael Bernhard
Breathing lime is used in closed circuit and semi-closed circuit rebreathers (CCR/SCR) for technical diving. Similar to the use in anesthesia systems, the lime usually contains hydroxycarbamide, which can react to caustic soda under the influence of water. The ingestion of components of the soda lime can lead to burns of the esophageal mucosa with the formation of colliquation necrosis and the danger of esophageal perforation. Early endoscopy is essential in this case to assess the consequences of ingestion...
February 16, 2021: Der Anaesthesist
https://read.qxmd.com/read/33560644/water-accumulation-in-amsorb-canister-may-cause-inspiratory-flow-obstruction-a-case-report
#19
JOURNAL ARTICLE
Jeffrey B Gross, Joseph P Scannell
A patient received closed-circuit anesthesia from a General Electric Avance S/5 (GE Healthcare, Madison, WI) anesthesia machine during a robotic abdominal procedure. With return of spontaneous ventilation at the end of the procedure, the negative airway pressure alarm began to sound, and a negative airway pressure of 10-15 cm H2O was observed with each breath. Replacing the CO2 absorber resolved the problem. There was considerable condensation on the walls of the Amsorb canister, and on disassembly, the sponge at the bottom was wet...
February 5, 2021: A&A Practice
https://read.qxmd.com/read/33501906/evidence-based-project-cost-savings-and-reduction-in-environmental-release-with-low-flow-anesthesia
#20
JOURNAL ARTICLE
Alicia Edmonds, Hilary Stambaugh, Scot Pettey, Kenn B Daratha
Volatile anesthetic agents act as greenhouse gases. Low-flow anesthesia techniques (≤1 L/min) are associated with lower costs. Decreasing volatile anesthetic delivery provides safe and effective strategies for anesthesia providers to decrease costs and reduce environmental pollution. This evidence-based project aimed to estimate cost savings and reduction in the environmental release of anesthetic gases, under simulated lower fresh gas flow (FGF) practices. For each surgical case, the exhaled anesthetic gas percent and FGF data were used to calculate the volume of fluid volatile anesthetic...
February 2021: AANA Journal
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