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https://www.readbyqxmd.com/read/28944718/obesity-is-associated-with-altered-mid-insula-functional-connectivity-to-limbic-regions-underlying-appetitive-responses-to-foods
#1
Jason A Avery, Joshua N Powell, Florence J Breslin, Rebecca J Lepping, Laura E Martin, Trisha M Patrician, Joseph E Donnelly, Cary R Savage, W Kyle Simmons
Obesity is fundamentally a disorder of energy balance. In obese individuals, more energy is consumed than is expended, leading to excessive weight gain through the accumulation of adipose tissue. Complications arising from obesity, including cardiovascular disease, elevated peripheral inflammation, and the development of Type II diabetes, make obesity one of the leading preventable causes of morbidity and mortality. Thus, it is of paramount importance to both individual and public health that we understand the neural circuitry underlying the behavioral regulation of energy balance...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28944591/the-impact-of-muc5b-gene-on-dental-caries
#2
Tayla Cavallari, Heloísa Salomão, Simone Tetu Moysés, Samuel Jorge Moysés, Renata Iani Werneck
OBJECTIVE: To identify the impact of MUC5B polymorphisms on dental caries. METHODS: A case-control study was performed with patients recruited at Pontifícia Universidade Católica do Paraná. This individuals were aged 12 years old or more. Dental caries was diagnosed using the International Caries Detection and Assessment System and the effects of socioeconomic, dietary, and hygiene factors on dental caries were investigated. Furthermore, buccal cells were collected, and their DNA was extracted and amplified using PCR...
September 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28944563/a-randomized-controlled-trial-of-levodopa-in-patients-with-angelman-syndrome
#3
Wen-Hann Tan, Lynne M Bird, Anjali Sadhwani, Rene L Barbieri-Welge, Steven A Skinner, Lucia T Horowitz, Carlos A Bacino, Lisa M Noll, Cary Fu, Rachel J Hundley, Logan K Wink, Craig A Erickson, Gregory N Barnes, Anne Slavotinek, Rita Jeremy, Alexander Rotenberg, Sanjeev V Kothare, Heather E Olson, Annapurna Poduri, Mark P Nespeca, Hillary C Chu, Jennifer M Willen, Kevin F Haas, Edwin J Weeber, Paul A Rufo
Treatment for Angelman syndrome (AS) is currently limited to symptomatic interventions. A mouse model of AS has reduced calcium/calmodulin-dependent kinase II activity due to excessive phosphorylation of specific threonine residues, leading to diminished long-term potentiation. In a rat model of Parkinson disease, levodopa reduced phosphorylation of various proteins, including calcium/calmodulin-dependent kinase II. Further studies demonstrated that AS mice treated with levodopa performed better on rotarod testing than untreated AS mice...
September 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28944499/fluoride-mouthrinses-for-preventing-dental-caries-in-children-and-adolescents
#4
REVIEW
Josie Bidwell
The Mission of the Cochrane Nursing Care Field (CNCF) is to improve health outcomes through increasing the use of the Cochrane Library and supporting Cochrane's role by providing an evidence base for nurses and related health care professionals involved in delivering, leading, or researching nursing care. The CNCF produces "Cochrane Corner" columns (summaries of recent nursing-care-relevant Cochrane Reviews) that are regularly published in collaborating nursing-care-related journals. Information on the processes this Field has developed can be accessed at: http://cncf...
September 25, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28944375/influence-of-different-calcium-phosphates-on-an-experimental-adhesive-resin
#5
Isadora Martini Garcia, Vicente Castelo Branco Leitune, Susana Maria Werner Samuel, Fabrício Mezzomo Collares
PURPOSE: To formulate adhesive resins with 2 wt% of hydroxyapatite (HAp), α-tricalcium phosphate (α-TCP), or octacalcium phosphate (OCP) and to compare these groups with an unfilled adhesive regarding the degree of conversion, polymerization rate, microshear bond strength and mineral deposition. MATERIALS AND METHODS: The experimental adhesive resin was formulated mixing 66.6 wt% bisphenol A glycol dimethacrylate (bis-GMA), 33.3 wt% 2-hydroxyethyl methacrylate (HEMA), and a photoinitiator system...
September 21, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28944293/preventing-caries-in-american-indian-children-lost-battle-or-new-hope
#6
J Albino, T S Batliner, T Tiwari
Knowledge Transfer Statement: Preventing early childhood caries in American Indian children has proved to be an unexpectedly challenging goal. Biological and behavioral variables, as well as parental psychosocial characteristics and experiences, suggest new routes for understanding and mitigating the progress of disease. We provide our reflections after a decade of studying these issues in collaboration with tribal communities.
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28942310/dental-and-temporomandibular-joint-pathology-of-the-north-american-brown-bear-ursus-arctos-horribilis-ursus-arctos-middendorffi-and-ursus-arctos-sitkensis
#7
J N Winer, B Arzi, S Döring, P H Kass, F J M Verstraete
Museum specimens (maxillae and mandibles) from 393 North American brown bears (Ursus arctos) from Alaska were examined macroscopically according to predefined criteria and 204 specimens were included in this study. The specimens were acquired between 1905 and 2012. There were 99 specimens (48.5%) from male animals, 87 (42.7%) from female animals and 18 (8.8%) from animals of unknown sex. The ages of the animals ranged from neonate to adult, with 92 adults (45.1%) and 112 young adults (54.9%) included and neonates/juveniles excluded from the study...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28941082/liver-biopsy-in-assessment-of-extended-criteria-donors
#8
Joseph B Oliver, Praveena Machineni, Advaith Bongu, Trusha Patel, Joseph Nespral, Carie Kadric, Michael J Goldstein, Harvey Lerner, David Gee, Richard Hillbom, Lloyd Brown, Kenneth Washburn, Baburao Koneru
INTRODUCTION: The safety and liver utilization with prerecovery liver biopsy (PLB) in extended criteria liver donors are unclear. METHODS: We conducted a retrospective cohort study in 1323 brain death donors (PLB=496) from three organ procurement organizations (OPOs). Outcomes were complications, preemption of liver recovery (PLR) and livers transplanted (LT). Additional analyses included liver only and propensity score-matched multiorgan donor subgroups. RESULTS: PLB donors were older (57yrs vs 53yrs, p<0...
September 21, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28940755/a-systematic-review-of-the-effects-of-supervised-toothbrushing-on-caries-incidence-in-children-and-adolescents
#9
REVIEW
Ana Paula Pires Dos Santos, Branca Heloisa de Oliveira, Paulo Nadanovsky
BACKGROUND: The anticaries effect of supervised toothbrushing, irrespective of the effect of fluoride toothpaste, has not been clearly determined yet. AIM: To assess the effects of supervised toothbrushing on caries incidence in children and adolescents. DESIGN: A systematic review of controlled trials was performed (CRD42014013879). Electronic and hand searches retrieved 2046 records, 112 of which were read in full and independently assessed by two reviewers, who collected data regarding characteristics of participants, interventions, outcomes, length of follow-up and risk of bias...
September 21, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28939374/factors-associated-with-early-outcomes-following-standardised-therapy-in-children-with-ulcerative-colitis-protect-a-multicentre-inception-cohort-study
#10
Jeffrey S Hyams, Sonia Davis, David R Mack, Brendan Boyle, Anne M Griffiths, Neal S LeLeiko, Cary G Sauer, David J Keljo, James Markowitz, Susan S Baker, Joel Rosh, Robert N Baldassano, Ashish Patel, Marian Pfefferkorn, Anthony Otley, Melvin Heyman, Joshua Noe, Maria Oliva-Hemker, Paul Rufo, Jennifer Strople, David Ziring, Stephen L Guthery, Boris Sudel, Keith Benkov, Prateek Wali, Dedrick Moulton, Jonathan Evans, Michael D Kappelman, Alison Marquis, Francisco A Sylvester, Margaret H Collins, Suresh Venkateswaran, Marla Dubinsky, Vin Tangpricha, Krista L Spada, Ashley Britt, Bradley Saul, Nathan Gotman, Jessie Wang, Jose Serrano, Subra Kugathasan, Thomas Walters, Lee A Denson
BACKGROUND: Previous retrospective studies of paediatric ulcerative colitis have had limited ability to describe disease progression and identify predictors of treatment response. In this study, we aimed to identify characteristics associated with outcomes following standardised therapy after initial diagnosis. METHODS: The PROTECT multicentre inception cohort study was based at 29 centres in the USA and Canada and included paediatric patients aged 4-17 years who were newly diagnosed with ulcerative colitis...
September 19, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28937907/direct-pulp-capping-in-primary-molars-using-mineral-trioxide-aggregate-an-in-vivo-study
#11
Elzbieta Luczaj-Cepowicz, Grazyna Marczuk-Kolada, Malgorzata Pawinska, Marta Obidzinska
OBJECTIVE: To do a clinical and radiographic evaluation of the effectiveness of MTA when used as a direct pulp capping material in primary molars. STUDY DESIGN: Clinical and radiographic follow-up was performed on 30 primary molars with deep caries lesions in 30 patients from 3 to 9.75 years of age. Pulps exposed during cavity preparation were treated by direct pulp capping with MTA. The follow-up clinical and radiographic examinations were carried out at different time intervals: 6, 7-12, 13-18, 19-24, and >24 months after treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937900/parents-attitude-towards-the-use-of-fluorides-and-fissure-sealants-and-its-effect-on-their-children-s-oral-health
#12
Sigalit Blumer, Tal Ratson, Benjamin Peretz, Nurit Dagon
OBJECTIVES: To characterize the attitudes of Israeli parents towards caries preventive measures. STUDY DESIGN: participating parents completed a 21-item questionnaire on their demographics, dental history, attitudes and satisfaction from fluorides and fissure sealants. RESULTS: One hundred parents (average age 41.62±4.9 years, 85 females) participated. Most of the parents (88% of the mothers and 84% of the fathers) had an academic education...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937897/the-role-of-genetic-factors-in-the-outbreak-mechanism-of-dental-caries
#13
Junko Shimomura-Kuroki, Tomoko Nashida, Yukio Miyagawa, Tsuneo Sekimoto
OBJECTIVE: The aim of the present study was to investigate the relationships between cariogenic bacterial infection and single nucleotide polymorphisms (SNPs) in candidate genes associated with dental caries, and to explore the factors related to caries in children. STUDY DESIGN: Children aged 3 to 11 years were selected. Detection of cariogenic bacteria (Streptococcus mutans, Streptococcus oralis, Streptococcus sobrinus and Lactobacillus) from the plaque of each patient, and SNP analyses of five candidate genes (MBL2, TAS2R38, GLUT2, MMP13 and CA6) were performed using DNA isolated from buccal mucosal cells...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937896/evaluation-of-oral-health-related-quality-of-life-to-assess-dental-treatment-in-preschool-children-with-early-childhood-caries-a-preliminary-study
#14
Ana Lúcia Vollú, Maria da Encarnação Perez Requejo da Costa, Lucianne Cople Maia, Andréa Fonseca-Gonçalves
PURPOSE: The oral health-related quality of life (OHRQoL) of preschool children with Early Childhood Caries (ECC) was used to assess the outcome of dental treatment. STUDY DESIGN: Children (3.56±1.31years) affected by ECC were selected. Anamnesis, clinical and radiographic exams were performed. Data about sociodemographic aspects, OHRQoL and dmf-t index were collected. The Brazilian version of Early Childhood Oral health Impact Scale (B-ECOHIS) was applied in two time intervals: before and after 30 days of treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937889/clinical-evaluation-of-ozone-on-dentinal-lesions-in-young-permanent-molars-using-the-stepwise-excavation
#15
Osama Safwat, Mona Elkateb, Karin Dowidar, Omar El Meligy
AIM: To evaluate the clinical changes in dentin of deep carious lesions in young permanent molars, following ozone application with and without the use of a remineralizing solution, using the stepwise excavation. STUDY DESIGN: The sample included 162 first permanent immature molars, showing deep occlusal carious cavities that were indicated for indirect pulp capping. Teeth were divided into 2 main groups according to the method of ozone treatment. Each group was further subdivided equally into test and control subgroups...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937103/new-chairside-guide-focuses-on-caries-prevention
#16
(no author information available yet)
No abstract text is available yet for this article.
September 22, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28937069/oral-health-in-diabetic-and-nondiabetic-patients-with-chronic-kidney-disease
#17
Lingam Amara Swapna, Pradeep Koppolu, Jyothi Prince
The objective of our study is to assess the subjective and objective oral manifestations and salivary pH in diabetic and nondiabetic uremic patients at a nephrology clinic. A total of 194 diabetic and nondiabetic patients with chronic kidney disease (CKD), who were divided into four groups, Group A, B, C, D, and who were attending a nephrology clinic were included in the study. Predialytic unstimulated whole salivary pH was recorded using pH- measuring strips. Subjective and objective findings were evaluated and recorded in the specially designed pro forma...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28936284/relationship-of-salivary-cd14-concentration-with-dental-caries-in-young-children
#18
Saurabh Kumar, Shobha Tandon, Rashmi Nayak, Runki Saran, Kalyana-Chakravarthy Pentapati
BACKGROUND: Dental caries is a chronic disease among children and there is need for studies assessing the caries risk factors using saliva. This study aimed to evaluate the association of salivary soluble CD14 and dental caries in young children. MATERIAL AND METHODS: A cross-sectional study was done among 300, 3-6 year old school children of Udupi district. A total of 40 children who were caries free, with no past systemic illness or craniofacial anomalies and 40 children with dental caries with no history of dental treatment for caries, with no past systemic illness or craniofacial anomalies were included in control and test groups respectively...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28936152/prevalence-and-severity-of-dental-caries-among-public-school-students-aged-16-l8-in-hai-l-kingdom-of-saudi-arabia
#19
Mohammad Aljanakh
OBJECTIVE: The objective of the study was to determine the prevalence and severity of dental caries among school students aged 16-18 in Ha'il urban city, Kingdom of Saudi Arabia (KSA). METHODS: This cross-sectional study randomly selected 480 students from eight secondary schools in Ha'il urban city from September to October 2015. Three calibrated examiners used the decayed, missing and filled teeth index (DMFT), based on the World Health Organization criteria, to examine the students...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28934367/exploring-the-salivary-microbiome-of-children-stratified-by-the-oral-hygiene-index
#20
Izumi Mashima, Citra F Theodorea, Boonyanit Thaweboon, Sroisiri Thaweboon, Frank A Scannapieco, Futoshi Nakazawa
Poor oral hygiene often leads to chronic diseases such as periodontitis and dental caries resulting in substantial economic costs and diminished quality of life in not only adults but also in children. In this study, the salivary microbiome was characterized in a group of children stratified by the Simplified Oral Hygiene Index (OHI-S). Illumina MiSeq high-throughput sequencing based on the 16S rRNA was utilized to analyze 90 salivary samples (24 Good, 31 Moderate and 35 Poor oral hygiene) from a cohort of Thai children...
2017: PloS One
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