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https://www.readbyqxmd.com/read/29331172/blood-phenylalanine-reduction-corrects-cns-dopamine-and-serotonin-deficiencies-and-partially-improves-behavioral-performance-in-adult-phenylketonuric-mice
#1
Shelley R Winn, Tanja Scherer, Beat Thöny, Ming Ying, Aurora Martinez, Sydney Weber, Jacob Raber, Cary O Harding
Central nervous system (CNS) deficiencies of the monoamine neurotransmitters dopamine and serotonin have been implicated in the pathophysiology of neuropsychiatric dysfunction in human phenylketonuria (PKU). In this study, we confirmed the occurrence of brain dopamine and serotonin deficiencies in association with severe behavioral alterations and cognitive impairments in hyperphenylalaninemic C57BL/6-Pahenu2/enu2 mice, a model of human PKU. Phenylalanine-reducing treatments, including either dietary phenylalanine restriction or liver-directed gene therapy, initiated during adulthood were associated with increased brain monoamine content along with improvements in nesting behavior but without a change in the severe cognitive deficits exhibited by these mice...
January 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29330840/clinical-assessment-of-class-ii-resin-based-composites-versus-preformed-metal-crowns-performed-on-primary-molars-in-patients-at-high-risk-of-caries
#2
A Alyahya, A Khanum, M Qudeimat
AIM: To compare class II resin composite with preformed metal crowns (PMC) in the treatment of proximal dentinal caries in high caries-risk patients. METHODS: The charts (270) of paediatric patients with proximal caries of their primary molars were reviewed. Success or failure of a procedure was assessed using the dental notes. Survival analysis was used to calculate the mean survival time (MST) for both procedures. The influence of variables on the mean survival time was investigated...
January 12, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29330524/nf-%C3%AE%C2%BAb-inducing-kinase-is-a-therapeutic-target-for-systemic-lupus-erythematosus
#3
Hans D Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B Gogol, Georgette M Castanedo, Benjamin T Jackson, Youngsu C Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M Berezhkovskiy, Peter W Fan, Zora Modrusan, Kelli Veliz, Michael J Townsend, Jason DeVoss, Adam R Johnson, Robert Godemann, Wyne P Lee, Cary D Austin, Brent S McKenzie, Jason A Hackney, James J Crawford, Steven T Staben, Moulay H Alaoui Ismaili, Lawren C Wu, Nico Ghilardi
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we show that experimental lupus in NZB/W F1 mice can be treated with a highly selective and potent NIK small molecule inhibitor. Both in vitro as well as in vivo, NIK inhibition recapitulates the pharmacological effects of BAFF blockade, which is clinically efficacious in SLE...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29329905/consensus-recommendations-for-evaluation-interpretation-and%C3%A2-utilization-of-computed-tomography-and-magnetic-resonance-enterography-in-patients-with-small-bowel-crohn-s%C3%A2-disease
#4
David H Bruining, Ellen M Zimmermann, Edward V Loftus, William J Sandborn, Cary G Sauer, Scott A Strong
Computed tomography and magnetic resonance enterography have become routine small bowel imaging tests to evaluate patients with established or suspected Crohn's disease, but the interpretation and use of these imaging modalities can vary widely. A shared understanding of imaging findings, nomenclature, and utilization will improve the utility of these imaging techniques to guide treatment options, as well as assess for treatment response and complications. Representatives from the Society of Abdominal Radiology Crohn's Disease-Focused Panel, the Society of Pediatric Radiology, the American Gastroenterological Association, and other experts, systematically evaluated evidence for imaging findings associated with small bowel Crohn's disease enteric inflammation and established recommendations for the evaluation, interpretation, and use of computed tomography and magnetic resonance enterography in small bowel Crohn's disease...
December 30, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29329566/general-and-erosive-tooth-wear-of-16-year-old-adolescents-in-kuantan-malaysia-prevalence-and-association-with-dental-caries
#5
Noorhazayti Ab Halim, Rashidah Esa, Hooi Pin Chew
BACKGROUND: The objective of this study was to determine the prevalence and severity of general tooth wear (GTW), i.e. tooth wear irrespective of etiology and erosive tooth wear (ETW), i.e. tooth wear predominantly due to erosion; and also to investigate the relationship between ETW and dental caries experience in 16-year-old adolescents in Kuantan, Malaysia. METHODS: A multi-staged cluster sampling method was employed. A total of 598 16-year-old adolescents participated in this study...
January 12, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29327482/streptococcus-oralis-maintains-homeostasis-in-supragingival-biofilms-by-antagonizing-cariogenic-pathogen-streptococcus-mutans
#6
Thomas Thurnheer, Georgios N Belibasakis
Bacteria residing in oral biofilms live in a state of dynamic equilibrium with one another. The intricate synergistic or antagonistic interactions between them are crucial for determining this balance. Using the 6-species Zürich "supragingival" biofilm model, this study aimed to investigate interactions regarding growth and localization of the constituent species. As control, an inoculum containing all six strains was used, whereas in each of the further five inocula one of the bacterial species was absent, and in the last both streptococci were absent...
January 11, 2018: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29326814/paediatric-dentistry-novel-evolvement
#7
REVIEW
Saleha Shah
Pediatric dentistry provides primary and comprehensive preventive and therapeutic oral health care for infants and children through adolescence, together with special health care needs. This specialty encompasses a variety of skills, disciplines, procedures and techniques that share a common origin with other dental specialties however these have been modified and reformed to the distinctive requirements of infants, children, adolescents and special health care needs. Disciplines comprise of behavior guidance, care of the medically and developmentally compromised and disabled patient, supervision of orofacial growth and development, caries prevention, sedation, pharmacological management, and hospital dentistry including other traditional fields of dentistry...
January 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29326522/fragile-x-syndrome-a-rare-case-report-with-unusual-oral-features
#8
Prayas Ray, Arpanna Singh, Jayanta Kumar Dash, Prasanna Kumar Sahoo, Jitendra Kumar Dash
Fragile X syndrome (FXS) is a rare variant of special health-care need demonstrating delayed developmental milestones and associated with intellectual and emotional disabilities ranging from learning problem to mental retardation. The syndrome is usually not diagnosed until 8-9 years of age since the clinical manifestations of the syndrome are greatly attenuated in childhood. The physical characteristics such as facial features, hyperactivity, attention deficit, autistic behavior, and macroorchidism are quite evident in younger age group...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326512/evaluating-the-effect-of-different-conditioning-agents-on-the-shear-bond-strength-of-resin-modified-glass-ionomers
#9
Namith Rai, Rajaram Naik, Ravi Gupta, Shobana Shetty, Amith Singh
Aim of the Study: This study aims to evaluate the effects three different conditioning agents on the shear bond strength of resin-modified glass ionomers to human dentin. Materials and Methods: One hundred and twenty recently extracted, caries-free premolars and molars will be cleaned of debris and disinfected in a 0.5% solution of sodium hypochlorite and sterile water for 30 min. The occlusal surface of each tooth will be reduced using conventional model trimmer with water to produce the dentin surface...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326510/isolation-and-typing-of-streptococcus-mutans-and-streptococcus-sobrinus-from-caries-active-subjects
#10
Hamzah Abdulrahman Salman, R Senthilkumar, Khalid Imran, K Panneer Selvam
Background: Streptococcus mutans and Streptococcus sobrinus are main etiological agents of dental caries. Aim: The aim of the study was to isolate, identify, characterize, and determine the minimum inhibitory concentration (MIC) of S. mutans and S. sobrinus from caries-active subjects. Materials and Methods: Sixty-five plaque samples were collected from caries-active subjects aged between 35 and 44 years, processed and cultured on mitis salivarius bacitracin agar...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326503/impact-of-dental-trauma-on-quality-of-life-among-11-14-years-schoolchildren
#11
Ibrahim Hassan El-Kalla, Hanaa Mahmoud Shalan, Rabaa Abo Bakr
Background: Traumatic injuries are common dental problems in pediatric dentistry that may influence the children's quality of life. Aim: the aim of this study is to assess the impact of traumatic dental injuries (TDI) and oral health-related quality of life (OHRQoL) among Egyptian schoolchildren aged 11-14 years. Materials and Methods: A cross-sectional study was carried out involving a sample of 11700 schoolchildren from public and private schools of Mansoura city, Egypt...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326501/analysis-of-salivary-iga-amylase-lactoferrin-and-lysozyme-before-and-after-comprehensive-dental-treatment-in-children-a-prospective-study
#12
Akhilesh Sharma, Priya Subramaniam, Shebin Moiden
Objective: This study aimed to evaluate the levels of salivary IgA, amylase, lactoferrin, and lysozyme before and after comprehensive dental treatment in children with early childhood caries. Design: Thirty children aged 36-60 months, with a deft score ≥5, were selected for the study. Before dental treatment, paraffin-stimulated whole saliva was collected in a sterile graduated cup for a period of 5 min. The saliva samples were quantitatively analyzed for levels of IgA, amylase, lactoferrin, and lysozyme using enzyme-linked immunosorbent assay...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326441/dental-caries-caries-risk-assessment-tools
#13
C A Yeung
No abstract text is available yet for this article.
January 12, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29326104/rethinking-neoadjuvant-chemotherapy-for-breast-cancer
#14
Jayant S Vaidya, Samuele Massarut, Hrisheekesh J Vaidya, Emma C Alexander, Thomas Richards, Jochem A Caris, Bhawna Sirohi, Jeffrey S Tobias
No abstract text is available yet for this article.
January 11, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29324814/comprehensive-molecular-profiling-of-advanced-metastatic-olfactory-neuroblastomas
#15
Jasmina Topcagic, Rebecca Feldman, Anatole Ghazalpour, Jeffrey Swensen, Zoran Gatalica, Semir Vranic
Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. This study retrospectively evaluated 23 ONB samples profiled at Caris Life Sciences (Phoenix, Arizona) using DNA sequencing (Sanger/NGS [Illumina], n = 15) and gene fusions (Archer FusionPlex, n = 6), whole genome RNA microarray (HumanHT-12 v4 beadChip, Illumina, n = 4), gene copy number assays (chromogenic and fluorescent in situ hybridization), and immunohistochemistry...
2018: PloS One
https://www.readbyqxmd.com/read/29323776/remineralization-of-natural-human-carious-dentin-lesions-with-an-experimental-whisker-reinforced-atraumatic-restorative-treatment-composite
#16
Chao Zhang, Stephen D Campbell, Sabine H Dickens, Bin Yang
PURPOSE: To evaluate the remineralization of natural human dentin caries with an experimental whisker-reinforced Atraumatic Restorative Treatment (ART) composite. MATERIALS AND METHODS: Teeth with moderate active dentin caries were prepared with caries-disclosing dye and hand instruments, restored with ART or resin-modified glass ionomer cement (RM-GIC), and then wet sliced into 120-μm sections with 15 sections in each group. After taking transverse microradiographs and implementing digital image analysis to determine the "mineral-loss-before," each section was incubated in artificial saliva solution (pH = 7...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29322626/restorations-in-primary-teeth-a-systematic-review-on-survival-and-reasons-for-failures
#17
REVIEW
Luiz Alexandre Chisini, Kauê Collares, Mariana Gonzalez Cademartori, Luísa Jardim Corrêa de Oliveira, Marcus Cristian Muniz Conde, Flávio Fernando Demarco, Marcos Britto Corrêa
BACKGROUND: Several restorative materials with specific indications are used for filling cavities in primary teeth. AIM: To systematically review the literature in order to investigate the longevity of primary teeth restorations and the reasons for failure. DESIGN: Electronic databases were screened, and eligible studies were hand-searched to find longitudinal clinical studies evaluating the survival of restorations (class I, class II, and crown) placed with different materials in primary teeth with at least one year of follow-up...
January 10, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29322499/effect-of-body-weight-and-behavioural-factors-on-caries-severity-in-mexican-rural-and-urban-adolescents
#18
Cynthia Lara-Capi, Maria Grazia Cagetti, Fabio Cocco, Peter Lingström, Franklin García-Godoy, Guglielmo Campus
OBJECTIVES: To investigate if, in Mexican adolescents, body weight and caries severity are associated, and if this association differs between rural and urban populations. METHODS: Adolescents from the rural area of Tepancan and the city of Veracruz were enrolled. Caries was recorded using the International Caries Detection and Assessment System and the body mass index (BMI) was calculated. Oral habits (toothbrushing, flossing, dental check-ups) and dietary patterns (sweets intake) were assessed...
January 11, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29321070/the-effect-of-methamphetamine-abuse-on-dental-caries-and-periodontal-diseases-in-an-eastern-china-city
#19
Tao Ye, Dongliang Sun, Guangying Dong, Guangjie Xu, Ligang Wang, Jinjin Du, Pengcheng Ren, Shibin Yu
BACKGROUND: Dental diseases are among the most frequently reported health problems in drug abusers. However, few studies have been conducted on oral health of methamphetamine (meth) abusers in China. The aim of the present study was to investigate the caries and periodontal health profile of former meth abusers in Eastern China. METHODS: A cross-sectional study was conducted on 162 former meth abusers in the male Zhoushan Compulsory Detoxification Center. A standardized questionnaire, which collected information about age, drug-use duration / pattern, oral hygiene habit and systemic diseases, was administered...
January 10, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29321029/association-of-caries-experience-and-dental-plaque-with-sociodemographic-characteristics-in-elementary-school-aged-children-a-cross-sectional-study
#20
Saeed Bashirian, Samaneh Shirahmadi, Shabnam Seyedzadeh-Sabounchi, Ali Reza Soltanian, Akram Karimi-Shahanjarini, Farshid Vahdatinia
BACKGROUND: Dental caries among Iranian elementary school children aged 6-12 years continue to rise. To estimate treatment needs and guide health initiatives, current epidemiologic data are required. Such data are currently unavailable for dental health. The purpose of this study was to assess caries experience, dental plaque, and associated factors in elementary school-aged children from Iran. METHODS: In this cross-sectional study, 988 elementary school children aged 7-12 years were selected by multistage cluster sampling...
January 10, 2018: BMC Oral Health
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