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https://www.readbyqxmd.com/read/29765826/rates-and-locations-of-regional-metastases-in-sinonasal-malignancies-the-mayo-clinic-experience
#1
Brandon W Peck, Kathryn M Van Abel, Eric J Moore, Daniel L Price
Objectives  The objective of this study was to identify factors that may influence the rate and location of regional metastasis in sinonasal malignancies (SNMs). Design  This is a retrospective review. Setting  This study was set at the single-institution tertiary referral center. Participants  A total of 299 patients were treated for SNMs from 1994 to 2014. Main Outcome Measures  The main outcome measures were incidence and distribution of regional metastases. Results  Several histologic subtypes were treated, with squamous cell carcinoma (28...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29748886/multifactorial-analysis-of-prognostic-factors-and-survival-rates-among-706-mucosal-melanoma-patients
#2
ChuanLiang Cui, Bin Lian, Li Zhou, Xin Song, XiaoShi Zhang, Di Wu, ZhiHong Chi, Lu Si, XiNan Sheng, Yan Kong, BiXia Tang, LiLi Mao, Xuan Wang, SiMing Li, Jie Dai, XieQiao Yan, Xue Bai, Charles M Balch, Jun Guo
BACKGROUND: The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis. METHODS: Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors. RESULTS: Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0...
May 10, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29746316/the-clinical-significance-of-kit-mutations-in-melanoma-a-meta-analysis
#3
Hui Z Gong, He Y Zheng, Jun Li
This study aimed to evaluate the association of KIT mutations with clinicopathologic features of melanomas using a meta-analysis and to identify differences between Asian and White populations using subgroup analyses. We selected 32 studies from the literature including 5224 patients. The pooled data were combined, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity and publication bias were also determined. KIT mutations were reported in 497 (9.5%) of 5224 patients with melanomas, and were associated significantly with age, clinical melanoma subtype, anatomic location, and chronic sun-damage (CSD), but not with sex, histological type, Breslow thickness, ulceration, mitotic rate, or tumor stage...
May 9, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29732360/primary-malignant-melanoma-of-the-small-intestine-a-report-of-2-cases-and-a-review-of-the-literature
#4
Kwan Mo Yang, Chan Wook Kim, So-Woon Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
The majority of malignant melanomas in the small intestine are metastases from primary cutaneous lesions, it can also develop as a primary mucosal tumor in the gastrointestinal tract. In this report, we present rare cases of primary small bowel melanoma and review the current literature. A 78-year-old male presented with abdominal pain and CT enterography identified a ileal mass. A 79-year-old female presented with signs and symptoms of partial small bowel obstruction. Abdominopelvic CT and small bowel series revealed a obstructing mass in the distal jejunum...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29725330/hyperprogressive-disease-in-anorectal-melanoma-treated-by-pd-1-inhibitors
#5
Marjorie Faure, Philippe Rochigneux, Daniel Olive, Sébastien Taix, Isabelle Brenot-Rossi, Marine Gilabert
The 5-year survival rate of primary anorectal malignant melanoma is less than 20%. Optimal treatment of this condition remains controversial regarding locally disease, and whether any preferential survival benefit arises from either abdominoperineal resection or wide local excision remains unknown. The majority of patients progress to metastatic disease, and for decades, the use of chemotherapies, such as platines or dacarbazine, has been advocated to improve overall survival. The therapeutic use of new checkpoint inhibitors in a variety of trials has provided evidence for an antitumoral effect of PD-1 and/or CTL4 inhibitors in mucosal melanomas, but these treatments must still be further evaluated...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29723382/what-does-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumors-2017-bring-new-about-mucosal-melanomas
#6
José Cândido Caldeira Xavier Júnior, Juliana Polizel Ocanha-Xavier
The recently published 4th Edition of the World Health Organization Classification of Head and Neck Tumors addresses the most relevant and updated aspects of tumor biology, including clinical presentation, histopathology, immunohistochemistry, and prognosis of head and neck tumors. The objective of the present study is to compare these updates to the 3rd edition of that book with regard to mucosal melanomas and to highlight the potential factors that differ those tumors from cutaneous melanomas. We observed progress in the understanding of oral and sinonasal mucosal melanomas, which also present themselves, in the molecular scope, differently form cutaneous melanomas...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29719740/abscopal-effect-in-a-stage-iv-melanoma-patient-who-progressed-on-pembrolizumab
#7
James M Tsui, Catalin Mihalcioiu, Fabio L Cury
In this case report, we present the clinical course of a woman with locally advanced mucosal melanoma of the oral cavity. She was initially treated with surgery with adjuvant local radiation of 50 Gy in 20 fractions. She quickly relapsed with an aggressive regional recurrence of the disease on the neck and with numerous pulmonary metastases. Immunotherapy with pembrolizumab was started, with initial good response and reduction in the size of the lesion in the neck. The regression, however, was short-lived, as the mass quickly grew at a remarkable rate and the lung lesions progressed significantly...
February 27, 2018: Curēus
https://www.readbyqxmd.com/read/29707161/immunotherapy-in-mucosal-melanoma-a-case-report-and-review-of-the-literature
#8
Hana Studentova, Hana Kalabova, Pavel Koranda, Karin Chytilova, Ladislava Kucerova, Bohuslav Melichar, David Vrana
Background: Mucosal melanoma is a rare form of melanoma presenting variably as sores or unexplained bleeding located mainly in the head and neck region, anorectal region or female genital tract. Mucosal melanoma is usually diagnosed at an advanced stage and is characterized by an aggressive behavior. Surgery represents the mainstay of treatment for early stage melanomas, but for advanced disease there have been until recently very limited treatment options. Ipilimumab, a human monoclonal antibody directed against the cytotoxic T lymphocyte antigen 4, was the first treatment modality to demonstrate survival benefit in advanced malignant melanoma...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29698627/bronchial-mucosal-interferon-%C3%AE-%C3%AE-and-pattern-recognition-receptor-expression-in-experimental-rhinovirus-induced-asthma-exacerbations
#9
Jie Zhu, Simon D Message, Patrick Mallia, Tatiana Kebadze, Marco Contoli, Christine K Ward, Elliot S Barnathan, Mary Ann Mascelli, Onn M Kon, Alberto Papi, Luminita A Stanciu, Michael R Edwards, Peter K Jeffery, Sebastian L Johnston
BACKGROUND: The innate immune system senses viral infection via pattern recognition receptors (PRRs) leading to type I interferon (IFN) production: their roles in rhinovirus (RV)-induced asthma exacerbations in vivo are uncertain. OBJECTIVES: To compare bronchial mucosal type I IFN and PRR expression at baseline and following RV infection in atopic asthmatic and control subjects. METHODS: Immunohistochemistry was used to detect expression of IFN-α, IFN-β and the PRRs, toll-like receptor (TLR)-3, melanoma-differentiation-associated gene-5 (MDA-5) and retinoic-acid-inducible protein-I (RIG-I) in bronchial biopsies from 10 atopic asthmatics and 15 non-asthmatic non-atopic controls at baseline and on day four and six weeks following RV infection...
April 23, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29686784/primary-malignant-melanoma-of-the-lung-a-case-report-of-a-rare-tumor-and-review-of-the-literature
#10
Muharrem Yunce, Stephen Selinger, William Krimsky, Daniel P Harley
Primary malignant melanoma of the lung (PMML) is a rare malignancy that exhibits aggressive behavior and has a very poor prognosis. We are reporting on a case of PMML in an otherwise healthy 22-year-old Caucasian male with no significant past medical history and an unremarkable family history. The patient initially presented with a 2-month history of a cough and an unexplained 22-lb weight loss. His initial chest X-ray demonstrated opacification of the right lower lobe (RLL) of his lung and a subsequent computerized tomography scan (CT scan) of his lung revealed a large mass occupying most of his RLL (Figure 1)...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29666297/phase-ii-study-of-everolimus-in-metastatic-malignant-melanoma-ncctg-n0377-alliance
#11
Jesus Vera Aguilera, Ravi D Rao, Jacob B Allred, Vera J Suman, Harold E Windschitl, Judith S Kaur, William J Maples, Val J Lowe, Edward T Creagan, Lori A Erickson, Svetomir Markovic
LESSONS LEARNED: Everolimus does not have sufficient activity to justify its use as single agent in metastatic melanoma.Patients treated with 10 mg per day dose were most likely to require dose reductions.Everolimus appeared to reduce the numbers of regulatory T cells in approximately half of the treated patients; unfortunately, these effects were not correlated with clinical outcomes. BACKGROUND: Everolimus (RAD-001) is an orally active rapamycin analogue shown in preclinical data to produce cytostatic cell inhibition, which may be potentially beneficial in treating melanoma...
April 17, 2018: Oncologist
https://www.readbyqxmd.com/read/29626308/patterns-of-treatment-failure-in-patients-with-sinonasal-mucosal-melanoma
#12
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
BACKGROUND: Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites. OBJECTIVE: The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure. METHODS: This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29624176/genital-mucosal-melanoma-with-somatic-sf3b1-r625c-mutation
#13
Naoki Oiso, Kazuko Sakai, Shigeto Yanagihara, Kazuto Nishio, Akira Kawada
No abstract text is available yet for this article.
April 6, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29600692/the-window-of-opportunities-for-targeted-therapy-in-brafwt-nraswt-kitwt-melanoma-biology-and-clinical-implications-of-fusion-proteins-and-other-mutations
#14
Marina Berger, Georg Richtig, Karl Kashofer, Ariane Aigelsreiter, Erika Richtig
Treatment options in advanced melanoma have been subject to a major change over the last years. The discovery of the oncogenic point mutation BRAFV600E and subsequently developed BRAF inhibitors had a major impact on patient's survival. Further important mutations have been found in the NRAS gene, although not yet druggable, and others involve c-kit in acral and mucosal melanoma. Imatinib was shown to achieve high response rates in c-kit mutated melanoma. Despite good response rates in these targeted therapies and introduction of immunotherapy, there are still patients left, who develop resistance upon therapy or patients without the option of targeted therapy...
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29600494/duox2-induced-innate-immune-responses-in-the-respiratory-epithelium-and-intranasal-delivery-of-duox2-dna-using-polymer-that-mediates-immunization
#15
REVIEW
Yung Jin Jeon, Hyun Jik Kim
Respiratory mucosa especially nasal epithelium is well known as the first-line barrier of air-borne pathogens. High levels of reactive oxygen species (ROS) are detected in in vitro cultured human epithelial cells and in vivo lung. With identification of NADPH oxidase (Nox) system of respiratory epithelium, the antimicrobial role of ROS has been studied. Duox2 is the most abundant Nox isoform and produces the regulated amount of ROS in respiratory epithelium. Duox2-derived ROS are involved in antiviral innate immune responses but more studies are needed to verify the mechanism...
March 30, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29569184/mucosal-melanoma-a-literature-review
#16
REVIEW
Simon Skovsted Yde, Pia Sjoegren, Martin Heje, Lars B Stolle
PURPOSE OF REVIEW: Mucosal melanoma is of great interest due to its aggressive behavior and less favorable prognosis. The literature is mainly case reports and case series. Here, we will collect the knowledge on mucosal melanoma from the last decade and review the literature. The main focus is being site-specific clinical features, treatment, and prognosis. RECENT FINDINGS: The use of immunotherapy gain ground as for others subsets of melanoma. Anti-CTLA-4 and anti-PD-1/ PD-L1 blockade in mucosal melanoma have been evaluated in recent studies...
March 23, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29535967/primary-sinonasal-mucosal-melanoma-simulated-as-cystic-lesions-a-case-report
#17
Sung-Ho Shin, Hyun Seok, Seong-Gon Kim, Seong-Doo Hong
Sinonasal mucosal melanoma (SNMM) in the maxillary sinus is a rare disease condition. Compared to oral mucosal melanoma, SNMM has a bulky, exophytic, and polypoid appearance, is weakly pigmented, and associated with unspecific symptoms. Due to these features, SNMM in the maxillary sinus has been misdiagnosed as nasal polyps and chronic sinusitis. In this case report, we described SNMM occurring in the right maxillary sinus simulated as a cystic or benign lesion. Cortical bone thinning and expansion were observed around the mass...
February 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29515387/a-case-of-erythema-multiforme-major-developed-after-sequential-use-of-two-immune-checkpoint-inhibitors-nivolumab-and-ipilimumab-for-advanced-melanoma-possible-implication-of-synergistic-and-or-complementary-immunomodulatory-effects
#18
Akira Utsunomiya, Noritaka Oyama, Shiro Iino, Natsuki Baba, Takenao Chino, Natsuko Utsunomiya, Minoru Hasegawa
Immune checkpoint inhibitors, such as ipilimumab and nivolumab, reverse the imbalance of antitumor self-tolerance and enhance T-cell responses. Currently, ipilimumab and nivolumab have a reported therapeutic impact on unresectable or metastatic melanomas; however, they also induce immune-related adverse events (irAEs). Ipilimumab-induced cutaneous irAEs are mostly low grade and manageable, although all-grade rash may occur in approximately 45% of all patients. We here report the case of a young woman with erythema multiforme major, which developed after sequential use of these 2 immune checkpoint inhibitors for advanced melanoma of the scalp...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29505523/aberrations-and-clinical-significance-of-braf-in-malignant-melanoma-a-series-of-60-cases-in-chinese-uyghur
#19
Xiaojing Kang, Ying Zeng, Junqin Liang, Jing Li, Danyang Ren, Li Chai, Zhenzhu Sun, Shirong Yu, Xiujuan Wu, Wen Han, Weijia Wang
Malignant melanoma (MM) is a highly malignant melanocytic tumor, it occurs mostly in the skin, the mucous membrane close to the skin, but also in the tunicae rhagoides and the pia mater. The Uyghur is the largest ethnic group living in the Xinjiang Uyghur Autonomous Region of China, accounting for 46% of the total population of 20 million. Large-scale studies on MMs in Asian countries are limited. This study aimed to investigate BRAF mRNA expression and mutations in Chinese Uyghur patients with MMs and to identify the clinical features associated with these parameters...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29492677/contemporary-treatment-approaches-to-sinonasal-mucosal-melanoma
#20
REVIEW
Moran Amit, Shorook Na'ara, Ehab Y Hanna
Sinonasal mucosal melanoma (SNMM) is a rare oncological entity that comprises most head and neck mucosal melanomas. SNMM has distinctive genetic background, different from cutaneous melanoma. Survival outcomes among SNMM patients are poor; while there is no clear consensus on the optimal management of SNMM, the primary treatment modality is generally considered to be wide surgical excision, and radiation therapy (RT) is often used in the postoperative adjuvant setting to improve locoregional control. Systemic therapies have demonstrated little or no survival benefit, and most SNMM patients die of distant metastatic disease...
February 28, 2018: Current Oncology Reports
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