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JOURNAL ARTICLE
Faizal Z Asumda, Nellie A Campbell, Mohamed A Hassan, Reza Fathi, Daniella F Vasquez Rico, Melanie Kiem, Ethan V Vang, Yo Han Kim, Xin Luo, Daniel R O'Brien, Sarah A Buhrow, Joel M Reid, Michael J Moore, Vered Katz Ben-Yair, Mark L Levitt, Jennifer L Leiting, Amro M Abdelrahman, Xinli Zhu, Fabrice Lucien, Mark J Truty, Lewis R Roberts
Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and the urokinase-type plasminogen activator (uPA). These enzymes are expressed in many cancers, especially during tissue remodeling and subsequent tumor cell invasion. Opaganib (ABC294640), a novel, orally available small molecule is a selective inhibitor of the phosphorylation of sphingosine to sphingosine-1-phosphate (S-1-P) by sphingosine kinase 2 (SPHK2)...
March 5, 2024: Cancers
#2
JOURNAL ARTICLE
Wenjing Wu, Yan Wang, Jingyi Chen, Fengju Zhang
PURPOSE: To explore the biomechanical proteins different between low myopic corneas and moderate to high myopic corneas. METHODS: A total of 27 myopic corneas were used for the Tandem Mass Tag (TMT) proteomics analysis. Differentially expressed proteins (DEPs) were clustered with fold changes > 1.20 or < 0.83 and p < 0.05. Proteins and Proteins Interactions (PPIs) were conducted to find hub proteins; Uniprot database was to screen proteins with biomechanical functions, and Parallel Reaction Monitoring (PRM) was performed to verify the TMT results...
March 11, 2024: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
#3
JOURNAL ARTICLE
Nianrong Mi, Zhe Li, Xueling Zhang, Yingjing Gao, Yanan Wang, Siyan Liu, Shaolian Wang
Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism resulting from autoantibody-induced stimulation of the thyroid gland. Despite recent advancements in understanding GD's pathogenesis, the molecular processes driving disease progression and treatment response remain poorly understood. In this study, we aimed to identify crucial immunogenic factors associated with GD prognosis and immunotherapeutic response. To achieve this, we implemented a comprehensive screening strategy that combined computational immunogenicity-potential scoring with multi-parametric cluster analysis to assess the immunomodulatory genes in GD-related subtypes involving stromal and immune cells...
March 15, 2024: Heliyon
#4
JOURNAL ARTICLE
Ivan Guerra, Francisco Barros, María Chaparro, José M Benítez, María Dolores Martín-Arranz, Ruth de Francisco, Marta Piqueras, Luisa de Castro, Ana Y Carbajo, Fernando Bermejo, Miguel Mínguez, Ana Gutiérrez, Francisco Mesonero, Fiorella Cañete, Carlos González-Muñoza, Marta Calvo, Beatriz Sicilia, Erika Alfambra, Montserrat Rivero, Alfredo J Lucendo, Carlos A Tardillo, Pedro Almela, Luis Bujanda, Manuel van Domselaar, Laura Ramos, María Fernández Sánchez, Esther Hinojosa, Cristina Verdejo, Anna Gimenez, Iago Rodríguez-Lago, Noemí Manceñido, José L Pérez Calle, Mónica Del Pilar Moreno, Pedro Genaro Delgado-Guillena, Beatriz Antolín, Patricia Ramírez de la Piscina, María José Casanova, Pilar Soto Escribano, Eduardo Martín Arranz, Isabel Pérez-Martínez, Raquel Mena, Natalia García Morales, Alicia Granja, Marta Maia Boscá Watts, Rubén Francés, Cristina Fernández, Margalida Calafat, Cristina Roig-Ramos, María Isabel Vera, Ángel Carracedo, Eugeni Domènech, Javier P Gisbert
BACKGROUND: Risk factors for developing pancreatitis due to thiopurines in patients with inflammatory bowel disease (IBD) are not clearly identified. AIM: Our aim was to evaluate the predictive pharmacogenetic risk of pancreatitis in IBD patients treated with thiopurines. METHODS: We conducted an observational pharmacogenetic study of acute pancreatitis events in a cohort study of IBD patients treated with thiopurines from the prospectively maintained ENEIDA registry biobank of GETECCU...
March 7, 2024: Digestive Diseases
#5
JOURNAL ARTICLE
Simon-Pierre Guay, Martine Paquette, Amélie Taschereau, Véronique Desgagné, Luigi Bouchard, Sophie Bernard, Alexis Baass
BACKGROUND: Multifactorial chylomicronemia syndrome (MCS) is a severe form of hypertriglyceridemia associated with an increased risk of acute pancreatitis (AP). The risk of AP is heterogenous and is associated with increased level of triglycerides (TG) and presence of rare variants in TG metabolism-related genes. OBJECTIVE: To determine if the accumulation of common variants in pancreatitis susceptibility genes, measured with a weighted polygenic risk score (PRS), is associated with AP in MCS patients...
February 23, 2024: Journal of Clinical Lipidology
#6
JOURNAL ARTICLE
Di Wu, Nan Ru, Yuan-Chen Wang, Guo-Xiu Ma, Tian-Yu Shi, Si-Huai Xiong, Ai-Jun You, Lei Wang, Liang-Hao Hu, Zhao-Shen Li, Wen-Bin Zou, Zhuan Liao
OBJECTIVES: The effects of genetic factors on pregnancy outcomes in chronic pancreatitis (CP) patients remain unclear. We evaluated the impacts of clinical features and mutations in main CP-susceptibility genes (SPINK1, PRSS1, CTRC, CFTR) on pregnancy outcomes in Chinese CP patients. METHODS: This was a prospective cohort study with 14-year follow-up. The sample comprised female CP patients with documented pregnancy and known genetic backgrounds. Adverse pregnancy outcomes were compared between patients with and without gene mutations...
February 9, 2024: Clinical and Translational Gastroenterology
#7
JOURNAL ARTICLE
Hui Liu, Xichen Wan, Liyun Yao, Qihan Zhao, Yong Yang, Hongtao Liu, Jun Shang, Fanfan Zeng, Xin Wang, Shaoxin Huang
BACKGROUND: Cadmium (Cd) exposure has been found to have detrimental effects on the development of the central nervous system and cognitive ability in children. However, there is ongoing debate regarding the impact of maternal Cd exposure on the cognitive ability of offspring. In this study, we aimed to investigate the mechanisms underlying the influence of maternal Cd exposure on the cognitive ability of offspring rats. METHODS: Here, we constructed a model of cadmium poisoning in first-generation rats through gavage...
January 29, 2024: European Journal of Medical Research
#8
REVIEW
Erum Khan, Soura Chakrabarty, Sanobar Shariff, Mainak Bardhan
Chronic pancreatitis is a long-term fibroinflammatory condition of the pancreas with varying incidences across countries. The recent increase in its occurrence implies the involvement of genetic, hereditary, and unconventional risk factors. However, there is a lack of updated literature on recent advances in genetic polymorphisms of chronic pancreatitis. Therefore, this review aims to present recent findings on the genetic implications of chronic pancreatitis based on individual gene mechanisms and to discuss epigenetics and epistasis involved in the disease...
December 2023: Global medical genetics
#9
JOURNAL ARTICLE
Hasan Baş, Selçuk Dişibeyaz, Erkin Öztaş, Yusuf Aydemir, Tuncer Temel, Oğuz Çilingir, Beyhan Durak Aras, Sevilhan Artan
BACKGROUND/AIMS: Pancreatitis is one of the leading causes of digestive system-related hospital admissions, and it has a genetic background in a considerable portion of the patients. In this study, we aimed to investigate the genetic risk factors of idiopathic pancreatitis in Turkish patients and the contribution of copy number variations to the pathogenesis. MATERIALS AND METHODS: Idiopathic pancreatitis is defined as failure to detect risk factors despite comprehensive clinical assessments...
October 12, 2023: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
#10
JOURNAL ARTICLE
Bechien U Wu, Qiaoling Chen, Becky H Moon, Eva Lustigova, Erin G Nielsen, Monica Alvarado, Syed A Ahmed
BACKGROUND: Screening for pancreatic cancer (PC) is suggested for high-risk individuals (HRI). Additional risk factors may enhance early detection in this population. METHODS: Retrospective cohort study among patients with germline variants and/or familial pancreatic cancer in an integrated healthcare system between 2003-2019. We calculated incidence rate (IR) by risk category and performed a nested case-control study to evaluate relationship between HbA1C and PC within 3 years prior to diagnosis(cases) or match date(controls)...
October 6, 2023: Clinical and Translational Gastroenterology
#11
JOURNAL ARTICLE
Huma Arshad Cheema, Zafar Fayyaz, Anjum Saeed, Muhammad Nadeem Anjum, Sadaqat Ijaz, Muhammad Arshad Alvi, Syeda Sara L Batoo
BACKGROUND/AIMS: The purpose of this study was to identify the spectrum and frequency of pathogenic variants as well as the clinical and genetic insight of hereditary chronic pancreatitis in Pakistani children. MATERIALS AND METHODS: The deoxyribonucleic acid of affected probands of 44 unrelated Pakistani families, having hereditary chronic pancreatitis-affected children, were subjected to massive parallel sequencing for candidate reported genes (SPINK1, PRSS1, CFTR, CPA1, CTRC, CBS, AGL, PHKB, and LPL)...
August 21, 2023: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
#12
JOURNAL ARTICLE
Emmanuelle Masson, Wen-Bin Zou, Na Pu, Vinciane Rebours, Emmanuelle Génin, Hao Wu, Jin-Huan Lin, Yuan-Chen Wang, Zhao-Shen Li, David N Cooper, Claude Férec, Zhuan Liao, Jian-Min Chen
BACKGROUND: PRSS1 was the first reported chronic pancreatitis (CP) gene. The existence of both gain-of-function (GoF) and gain-of-proteotoxicity (GoP) pathological PRSS1 variants, together with the fact that PRSS1 variants have been identified in CP subtypes spanning the range from monogenic to multifactorial, has made the classification of PRSS1 variants very challenging. METHODS: All currently reported PRSS1 variants (derived primarily from two databases) were manually reviewed with respect to their clinical genetics, functional analysis and population allele frequency...
August 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#13
JOURNAL ARTICLE
M M Litvinova, K F Khafizov, A S Speranskaya, A D Matsvay, A Yu Asanov, K A Nikolskaya, L V Vinokurova, E A Dubtsova, M G Ipatova, T F Mukhina, M A Karnaushkina, D S Bordin
UNLABELLED: The aim of the study was to define the spectrum of genetic risk factors of chronic pancreatitis (CP) development in patients living in the European part of the Russian Federation. MATERIALS AND METHODS: The study group included 105 patients with CP, with the age of the disease onset under 40 years old (the average age of onset was 26.9 years). The control group consisted of 76 persons without clinical signs of pancreatitis. The diagnosis of chronic pancreatitis in patients was made on the basis of clinical manifestations and the results of laboratory and instrumental investigations...
2023: Sovremennye Tekhnologii V Meditsine
#14
JOURNAL ARTICLE
Tianxiang Geng, Mengxue Zheng, Yongfeng Wang, Janne Elin Reseland, Athina Samara
Background: Ovarian Serous Adenocarcinoma is a malignant tumor originating from epithelial cells and one of the most common causes of death from gynecological cancers. The objective of this study was to develop a prediction model based on extracellular matrix proteins, using artificial intelligence techniques. The model aimed to aid healthcare professionals to predict the overall survival of patients with ovarian cancer (OC) and determine the efficacy of immunotherapy. Methods: The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) data collection was used as the study dataset, whereas the TCGA-Pancancer dataset was used for validation...
2023: Frontiers in Molecular Biosciences
#15
JOURNAL ARTICLE
Elena Jamali, Arash Safarzadeh, Bashdar Mahmud Hussen, Thomas Liehr, Soudeh Ghafouri-Fard, Mohammad Taheri
Pancreatic ductal adenocarcinoma (PDAC) is a cancer that is usually diagnosed at late stages. This highly aggressive tumor is resistant to most therapeutic approaches, necessitating identification of differentially expressed genes to design new therapies. Herein, we have analyzed single cell RNA-seq data with a systems biology approach to identify important differentially expressed genes in PDAC samples compared to adjacent non-cancerous samples. Our approach revealed 1462 DEmRNAs, including 1389 downregulated DEmRNAs (like PRSS1 and CLPS) and 73 upregulated DEmRNAs (like HSPA1A and SOCS3), 27 DElncRNAs, including 26 downregulated DElncRNAs (like LINC00472 and SNHG7) and 1 upregulated DElncRNA (SNHG5)...
June 13, 2023: Pathology, Research and Practice
#16
JOURNAL ARTICLE
Lu Yan, Min-Yue Jiang, Xin-Sheng Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease with limited therapy. Renshen Pingfei Formula (RPFF), a classic Chinese medicine derivative formula, has been shown to exert therapeutic effects on IPF. AIM OF THE STUDY: The study aimed to explore the anti-pulmonary fibrosis mechanism of RPFF through network pharmacology, clinical plasma metabolomics, and in vitro experiment. METHODS: Network pharmacology was used to study the holistic pharmacological mechanism of RPFF in the treatment of IPF...
June 10, 2023: Journal of Ethnopharmacology
#17
JOURNAL ARTICLE
Xin Lu, Yan He, Yue Liu, Xin-Ping Wang, Yu-Ling Xue, Zi-Yi Zheng, Su-Yang Duan, Hong-Liang Kong, Rong-Zhi Zhang, Jiao-Long Huang, Jie Deng, Peng Duan
Ionic liquids (ILs) are thought to have negative effects on human health. Researchers have explored the effects of ILs on zebrafish development during the early stages, but the intergenerational toxicity of ILs on zebrafish development has rarely been reported. Herein, parental zebrafish were exposed to different concentrations (0, 12.5, 25, and 50 mg/L) of [Cn mim]NO3 (n = 2, 4, 6) for 1 week. Subsequently, the F1 offspring were cultured in clean water for 96 h. [Cn mim]NO3 (n = 2, 4, 6) exposure inhibited spermatogenesis and oogenesis in F0 adults, even causing obvious lacunae in the testis and atretic follicle oocytes in ovary...
June 10, 2023: Environmental Toxicology
#18
JOURNAL ARTICLE
Bryson W Katona, Kelsey Klute, Randall E Brand, Jessica N Everett, James J Farrell, Kieran Hawthorne, Vivek Kaul, Sonia S Kupfer, Salvatore Paiella, Diane M Simeone, Daniel A Sussman, George Zogopoulos, Aimee L Lucas, Fay Kastrinos
UNLABELLED: Since its inception two years ago, the international, multicenter Pancreatic Cancer Early Detection (PRECEDE) Consortium has enrolled high-risk individuals (HRI) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Herein we aim to evaluate enrollment disparities in PRECEDE. Data on HRIs enrolled between May 2020 and March 2022 were collected, with HRIs defined as participants enrolled in PRECEDE meeting guideline-based criteria for PDAC surveillance. Of 1,273 HRIs enrolled, 1,113 were eligible for inclusion, with 47...
June 1, 2023: Cancer Prevention Research
#19
JOURNAL ARTICLE
Zhangyong Ren, Bing Pan, Fangfei Wang, Shaocheng Lyu, Jialei Zhai, Xiumei Hu, Zhe Liu, Lixin Li, Ren Lang, Qiang He, Xin Zhao
BACKGROUND: Understanding the spatial heterogeneity of the tumor microenvironment (TME) in pancreatic cancer (PC) remains challenging. METHODS: In this study, we performed spatial transcriptomics (ST) to investigate the gene expression features across one normal pancreatic tissue, PC tissue, adjacent tumor tissue, and tumor stroma. We divided 18,075 spatial spots into 22 clusters with t-distributed stochastic neighbor embedding based on gene expression profiles...
2023: Frontiers in Oncology
#20
JOURNAL ARTICLE
Junde Zhao, Wenjian Jiao, Xiaohui Sui, Jiani Zou, Jiuling Wang, Zhiheng Lin
OBJECTIVE: Endometrial cancer is one of the most common tumors of the female reproductive system, and the existing treatment options for advanced and metastatic endometrial cancer have certain limitations. The antitumor activity of luteolin has been gradually discovered. The purpose of this study was to predict the potential of luteolin in the treatment of endometrial cancer and to provide reference for future clinical drug use. METHODS: The target gene database of luteolin and differential gene dataset of uterine corpus endometrial carcinoma (UCEC) have been constructed to obtain the differential genes (DR-DEGs) for luteolin and UCEC...
2023: American Journal of Translational Research
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