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Amanda R Jimenez, Arielle Shaeffer Weiss, Anthony C Campagna
Lung Cancer is the primary cause of cancer-related death in the United States. We have recognized a need for novel methods of identification and consideration of enrollment into a lung cancer screening program for those at the highest risk of lung cancer. Our primary goal was to determine if pulmonary function test (PFT) demographic data would be useful in identifying patients for lung cancer screening. We retrospectively reviewed PFTs performed at Lahey Hospital & Medical Center (LHMC) January 2012 through January 2013 and found that of patients identified as high risk of lung cancer, 89% had passed through our PFT lab but had not yet been screened...
February 19, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Thijs T Wingelaar, Paul Clarijs, Pieter-Jan Am van Ooij, Dave Aa Koch, Rob A van Hulst
INTRODUCTION: Pulmonary function testing (PFT) is an important part of dive medical examinations. Depending on the standard used to assess fitness to dive, different reference sets and fixed cut-off points are used. Reference values are part of an ongoing debate regarding the validity and accuracy related to different age groups, sex and ethnic backgrounds. The Global Lung Initiative (GLI) has provided an all-age reference set which corrects for sex and ethnicity (GLI-2012); this has had substantial impact on pulmonary medicine...
March 31, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Soyoung Park, Ah-Young Oh, Jung-Hyun Cho, Min-Ho Yoon, Tae-Guen Woo, Somi Kang, Ho-Young Lee, Yunjin Jung, Bum-Joon Park
Quinacrine (QNC), anti-protozoan drug commonly used against Malaria and Giardiasis, has been recently tried for rheumatics and prion diseases via drug repositioning. In addition, several reports suggest anti-tumor effects of QNC through suppression of NF-κB and activation of p53. This study, demonstrates the anti-cancer effect of QNC via a novel pathway through the elimination of check point kinase 1/2 (Chk1/2) under p53 inactivated conditions. Inhibition of p53, by PFT-α or siRNA, promotes QNC-induced apoptosis in normal fibroblast and p53-intact cancer cells...
March 15, 2018: Molecular Cancer Research: MCR
Erin L Beatty, Alexandra Muller-Gass, Dorothy Wojtarowicz, Marie-Eve Jobidon, Ingrid Smith, Quan Lam, Oshin Vartanian
Humans rely on topographical memory to encode information about spatial aspects of environments. However, even though people adopt different strategies when learning new maps, little is known about the impact of those strategies on topographical memory, and their neural correlates. To examine that issue, we presented participants with 40 unfamiliar maps, each of which displayed one major route and three landmarks. Half were instructed to memorize the maps by focusing on the route, whereas the other half memorized the maps by focusing on the landmarks...
March 14, 2018: Neuroreport
Douglas C Johnson
No abstract text is available yet for this article.
March 13, 2018: American Journal of Respiratory and Critical Care Medicine
Bruce H Culver, Brian L Graham, Neil R MacIntyre, Meredith McCormack, David A Kaminsky, Allan L Coates, Daniel J Weiner, Margaret Rosenfeld, Jack Wanger
No abstract text is available yet for this article.
March 13, 2018: American Journal of Respiratory and Critical Care Medicine
Francis Ali-Osman, Alicia Mangram, Joseph Sucher, Gina Shirah, Van Johnson, Phillip Moeser, Natasha K Sinchuk, James K Dzandu
BACKGROUND: Patient outcomes after muscle sparing minimally invasive thoracotomy rib fixation (MSMIT-ORF) in geriatric G60 trauma patients remain poorly studied. This study determined the effect of MSMIT-ORF on pulmonary function (PFT). Non-operatively managed (NOM) patients were also described. METHODS: Medical records of G60 patients with severe rib fractures with PFTs measured before and after MSMIT-ORF were examined. Patient outcomes (MSMIT-ORF vs NOM) were adjusted in a multivariate logistic regression model...
February 20, 2018: American Journal of Surgery
Manu Jain, Grs Budinger, Borko Jovanovic, Jane Dematte, Sara Duffey, Jayesh Mehta
Pulmonary chronic graft-versus-host disease (p-CGVHD) following allogeneic HSCT is devastating with limited proven treatments. Although sporadically associated with pulmonary toxicity, the proteasome inhibitor bortezomib may be efficacious in p-CGVHD. We sought to establish safety and tolerability of bortezomib in pilot, open-label trial of patients with p-CGVHD. The primary endpoint was adverse events. Efficacy was assessed by comparing FEV1 decline prior to p-CGVHD diagnosis to during the bortezomib treatment period...
March 9, 2018: Bone Marrow Transplantation
Gloria Pelizzo, Anna Guddo, Aurora Puglisi, Annalisa De Silvestri, Calogero Comparato, Mario Valenza, Emanuele Bordonaro, Valeria Calcaterra
The reliability of wearable photoplethysmography (PPG) sensors to measure heart rate (HR) in hospitalized patients has only been demonstrated in adults. We evaluated the accuracy of HR monitoring with a personal fitness tracker (PFT) in children undergoing surgery. HR monitoring was performed using a wrist-worn PFT (Fitbit Charge HR) in 30 children (8.21 ± 3.09 years) undergoing laparoscopy ( n = 8) or open surgery ( n = 22). HR values were analyzed preoperatively and during surgery. The accuracy of HR recordings was compared with measurements recorded during continuous electrocardiographic (cECG) monitoring; HRs derived from continuous monitoring with pulse oximetry (SpO2R) were used as a positive control...
March 8, 2018: Children
Myung Hee Chung, Bo Mi Gil, Soon Seog Kwon, Hae-Il Park, Sun Wha Song, Na Young Jung, Won Jong Yoo
OBJECTIVES: To determine what computed tomographic (CT) dimensions can predict obstructive lung disease on routine chest CT scans by comparing morphological and densitometric CT findings with pulmonary function test (PFT) in normal subjects and patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: Consecutive patients (n = 646; 260 females and 386 males; mean age 54.9 years, ranged 20-90 years) who received chest CT scans with densitometry during a 3-month period were retrospectively analyzed in single center...
March 2018: European Journal of Radiology
Jennifer L A Tran, Rena Sheng, Allyson Beaulieu, Miguel Villodas, Keith McBurnett, Linda J Pfiffner, Leslie Wilson
We conducted a cost-effectiveness analysis (CEA) of two behavioral psychosocial interventions for children with ADHD-inattentive type: Child Life and Attention Skills (CLAS) program and parent-focused treatment (PFT) compared to community-based treatment as usual (TAU). The CEA evaluated cost per ADHD case resolved measured by parent and teacher reports of ADHD inattentive symptoms. Total cost per patient for CLAS, PFT, and TAU were $1559, $710, and $0. CLAS, the costliest treatment, was more effective than PFT and TAU...
February 26, 2018: Administration and Policy in Mental Health
Sibel Mentese, Coskun Bakar, Nihal Arzu Mirici, Sibel Oymak, Muserref Tatman Otkun
Few epidemiological studies investigating the association between air pollution and health are available in Turkey. The aim of this cohort-type study is to examine the relationships between ambient air quality, respiratory diseases, and decreases in pulmonary function over a year in three different towns in Canakkale: Canakkale Central town (region I), Lapseki town center (region II), and Can town (region III). Region III had four different sub-regions, which were Can town center (region III-A), and the villages located around Can town, namely Durali (region III-B), Kulfal (region III-C), and Yuvalar (region III-D)...
February 24, 2018: Environmental Science and Pollution Research International
Reema Kathuria, Kausik Chattopadhyay
Vibrio cholerae cytolysin (VCC) is a membrane-damaging protein toxin with potent cytolytic/cytotoxic activity against wide range of eukaryotic cells. VCC is a β-barrel pore-forming toxin (β-PFT), and it inflicts damage to the target cell membranes by forming transmembrane heptameric β-barrel pores. To exert pore-forming activity, VCC must bind to the cell membranes in an efficient manner. Efficient interaction with the cell membranes is an essential pre-requisite to trigger subsequent structural/conformational and organizational changes in the toxin molecules leading toward formation of the transmembrane oligomeric β-barrel pores...
February 22, 2018: IUBMB Life
Yetian Li, Fei Sheng, Chao Xia, Leilei Xu, Yong Qiu, Zezhang Zhu
STUDY DESIGN: A retrospective study. OBJECTIVES: To investigate the severity of pulmonary function impairment for AMC patients with concomitant scoliosis and to determine risk factors associated with the impaired pulmonary function in these patients.Summary of Background Data Arthrogryposis multiplex congenital (AMC) patients are generally believed to have impaired pulmonary function. However, the severity of respiratory morbidity and the associated risk factors have not been reported...
February 16, 2018: Spine
Aarti Shakkottai, Niko Kaciroti, Lauren Kasmikha, Samya Z Nasr
OBJECTIVE: Medication adherence among adolescents with cystic fibrosis (CF) is often suboptimal and this has significant impact on their health and quality of life. The purpose of the study was to evaluate the impact of frequent home pulmonary function (PFT) monitoring on medication adherence among adolescents with CF. HYPOTHESIS: We hypothesized that weekly home PFT monitoring will improve adherence while not significantly adding to the treatment burden. METHODS: Individuals aged 12-21 years with CF were provided a spirometer to measure PFTs weekly for 1 year...
February 19, 2018: Pediatric Pulmonology
Hatice Kilic, Asiye Kanbay, Aysegul Karalezli, H Canan Hasanoglu, Elif Babaoglu, Ozcan Erel, Can Ates
OBJECTIVE: To investigate the relationship between serum values of magnesium and the parameters of pulmonary function tests (PFT) in patients with chronic asthma. SUBJECTS AND METHODS: This study recruited 50 patients with chronic stable asthma and 40 healthy individuals as a control group. Data on age, sex, severity of asthma, PFT and details of drug therapy were obtained from each group. Serum magnesium, potassium, phosphorus, calcium, and sodium levels were also measured...
February 18, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Mizuho Nishio, Yutaka Tanaka
PURPOSE: To utilize Gaussian mixture model (GMM) for the quantification of chronic obstructive pulmonary disease (COPD) and to evaluate the combined use of multiple types of quantification. MATERIALS AND METHODS: Eighty-seven patients (67 men, 20 women; age, 67.4 ± 11.0 years) who had undergone computed tomography (CT) and pulmonary function test (PFT) were included. The heterogeneity of CT attenuation in emphysema (HC) was obtained by analyzing a distribution of CT attenuation with GMM...
2018: PloS One
Hanna M Nurmi, Hannu-Pekka Kettunen, Sanna-Katja Suoranta, Minna K Purokivi, Miia S Kärkkäinen, Tuomas A Selander, Riitta L Kaarteenaho
OBJECTIVE: To compare the presence and extent of several high-resolution computed tomography (HRCT) observations in different subtypes of rheumatoid arthritis-related interstitial lung disease (RA-ILD) and to examine associations between radiological findings, hospitalization, age, RA duration, pulmonary function tests (PFT) and survival. MATERIALS AND METHODS: HRCTs from 60 RA-ILD patients were independently evaluated and re-categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and unclassified subtypes by two radiologists...
January 2018: Respiratory Medicine
Mohammad Reza Khazdair, Omid Rajabi, Mahdi Balali-Mood, Farimah Beheshti, Mohammad Hossein Boskabady
BACKGROUND: Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, oxidant/antioxidant markers and pulmonary function tests (PFT) in veterans, 27-30 years after exposed to SM were studied. MATERIALS AND METHODS: Forty seven veterans allocated to three groups included: placebo group (P) and two groups treated with 5 and 10 mg/kg/day of Z...
January 16, 2018: Environmental Toxicology and Pharmacology
Ya-Ni Huang, Ling-Yu Yang, Nigel H Greig, Yu-Chio Wang, Chien-Cheng Lai, Jia-Yi Wang
Cortical and hippocampal neuronal damages caused by traumatic brain injury (TBI) are associated with motor and cognitive impairments; however, only little attention paid to the striatal damage. It is known that the p53 tumor-suppressor transcription factor participated in TBI-induced secondary brain damage. We investigated how the p53 inactivator pifithrin (PFT)-α affected TBI-induced striatal neuronal damage at 24 h post-injury. Sprague-Dawley rats subjected to a controlled cortical impact were used as TBI models...
February 5, 2018: Scientific Reports
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