Jaka Fadraersada, Raúl Alva-Gallegos, Pavel Skořepa, František Musil, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Markéta Paclíková, Alejandro Carazo, Vladimír Blaha, Přemysl Mladěnka
An imbalance in coagulation is associated with cardiovascular events. For prevention and treatment, anticoagulants, currently mainly xabans and gatrans, are used. The purpose of the present study was to provide a head-to-head comparison since there are no studies directly evaluating these novel anticoagulants. An additional aim was to find whether selected anthropological and biochemical factors can affect their anticoagulant properties as they are used in fixed doses. In this cross-sectional study, blood from 50 generally healthy donors was collected, and coagulation responses to dabigatran, argatroban, rivaroxaban, and apixaban, at a concentration of 1 μM, were analyzed...
December 19, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology