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https://www.readbyqxmd.com/read/29882452/cost-effectiveness-modeling-for-neuropathic-pain-treatments-investigating-the-relative-importance-of-parameters-using-an-open-source-model
#1
Matthew Hirst, Matthew W Bending, Gianluca Baio, Amina Yesufu-Udechuku, William C N Dunlop
AIMS: The study objective was to develop an open-source replicate of a cost-effectiveness model developed by National Institute for Health and Care (NICE) in order to explore uncertainties in health economic modeling of novel pharmacological neuropathic pain treatments. MATERIALS AND METHODS: The NICE model, consisting of a decision tree with branches for discrete levels of pain relief and adverse event (AE) severities, was replicated using R and used to compare a hypothetical neuropathic pain drug to pregabalin...
June 8, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29879685/cost-utility-analysis-of-searching-electronic-health-records-and-cascade-testing-to-identify-and-diagnose-familial-hypercholesterolaemia-in-england-and-wales
#2
Paul Crosland, Ross Maconachie, Sara Buckner, Hugh McGuire, Steve E Humphries, Nadeem Qureshi
BACKGROUND AND AIMS: The cost effectiveness of cascade testing for familial hypercholesterolaemia (FH) is well recognised. Less clear is the cost effectiveness of FH screening when it includes case identification strategies that incorporate routinely available data from primary and secondary care electronic health records. METHODS: Nine strategies were compared, all using cascade testing in combination with different index case approaches (primary care identification, secondary care identification, and clinical assessment using the Simon Broome (SB) or Dutch Lipid Clinic Network (DLCN) criteria)...
May 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29859057/sodium-valproate-in-pregnancy-what-are-the-risks-and-should-we-use-a-shared-decision-making-approach
#3
Alastair Macfarlane, Trisha Greenhalgh
BACKGROUND: Despite significant teratogenic risks, sodium valproate is still widely prescribed in many countries to women of childbearing age, as a mood stabiliser in bipolar disorder and also in epilepsy. The UK has recently banned valproate use in women who are not in a pregnancy prevention programme. Whilst this ruling reflects prevailing clinical practice, it also highlights an ongoing debate about when (if ever) a woman who is or could become pregnant should be allowed to choose to take valproate...
June 1, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29858635/correction-to-applicability-and-accuracy-of-pretest-probability-calculations-implemented-in-the-nice-clinical-guideline-for-decision-making-about-imaging-in-patients-with-chest-pain-of-recent-onset
#4
Robert Roehle, Viktoria Wieske, Georg M Schuetz, Pascal Gueret, Daniele Andreini, Willem Bob Meijboom, Gianluca Pontone, Mario Garcia, Hatem Alkadhi, Lily Honoris, Jörg Hausleiter, Nuno Bettencourt, Elke Zimmermann, Sebastian Leschka, Bernhard Gerber, Carlos Rochitte, U Joseph Schoepf, Abbas Arjmand Shabestari, Bjarne Nørgaard, Akira Sato, Juhani Knuuti, Matthijs F L Meijs, Harald Brodoefel, Shona M M Jenkins, Kristian Altern Øvrehus, Axel Cosmus Pyndt Diederichsen, Ashraf Hamdan, Bjørn Arild Halvorsen, Vladimir Mendoza Rodriguez, Yung Liang Wan, Johannes Rixe, Mehraj Sheikh, Christoph Langer, Said Ghostine, Eugenio Martuscelli, Hiroyuki Niinuma, Arthur Scholte, Konstantin Nikolaou, Geir Ulimoen, Zhaoqi Zhang, Hans Mickley, Koen Nieman, Philipp A Kaufmann, Ronny Ralf Buechel, Bernhard A Herzog, Melvin Clouse, David A Halon, Jonathan Leipsic, David Bush, Reda Jakamy, Kai Sun, Lin Yang, Thorsten Johnson, Jean-Pierre Laissy, Roy Marcus, Simone Muraglia, Jean-Claude Tardif, Benjamin Chow, Narinder Paul, David Maintz, John Hoe, Albert de Roos, Robert Haase, Michael Laule, Peter Schlattmann, Marc Dewey
The original version of this article, published on 19 March 2018, unfortunately contained a mistake. The following correction has therefore been made in the original: The names of the authors Philipp A. Kaufmann, Ronny Ralf Buechel and Bernhard A. Herzog were presented incorrectly.
June 1, 2018: European Radiology
https://www.readbyqxmd.com/read/29858433/crohn-s-disease-management-in-adults-children-and-young-people-concise-guidance
#5
Gloria Sz Tun, Sarah Cripps, Alan J Lobo
Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract. Individuals with CD present with acute inflammatory exacerbations as well as acute and chronic complications. Management requires specialist input from gastroenterologists, colorectal surgeons, nurse specialists and pharmacists as well as general and primary care physicians to allow appropriate selection of treatment options including surgery and rapid assessment and treatment of those with acute exacerbations. Monitoring of the individual and their medication is crucial in preventing and recognising complications including those associated with treatment...
June 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29843807/what-is-the-impact-of-regulatory-guidance-and-expiry-of-drug-patents-on-dementia-drug-prescriptions-in-england-a-trend-analysis-in-the-clinical-practice-research-datalink
#6
Venexia M Walker, Neil M Davies, Patrick G Kehoe, Richard M Martin
BACKGROUND: Drugs for dementia have been available in England since 1997. Since their launch, there have been several changes to national guidelines and initiatives that may have influenced prescribing. These include changes in National Institute for Health and Care Excellence (NICE) guidance, several government dementia strategies, the addition of dementia to the Quality and Outcomes Framework (QOF), and the expiry of drug patents. Despite this, there has been little research into the effect of these events on prescribing...
May 29, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29796026/a-systematic-review-of-clinical-practice-guidelines-for-castration-resistant-prostate-cancer
#7
Mohamad Javad Foroughi Moghadam, Saeed Taheri, Farzad Peiravian
Cancer constitutes a huge burden on societies in countries with any level of economic development. Prostate cancer is the first most diagnosed cancer of men in developed countries and the forth one in developing countries in terms of incidence rate. It is also the third incident cancer of men in Iran along with a prevalence of about 10,000 cases. Castration-resistant prostate cancer (CRPC) is a severe stage of the disease with a number of newly discovered treatment options. These therapeutic alternatives including abiraterone acetate, enzalutamide, cabazitaxel, immunotherapy with sipuleucel-T, radiopharmaceuticals and bone-targeted therapies (zoledronic acid, denosumab) along with docetaxel have made the decision making process complex and challenging for clinicians...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29787524/critical-appraisal-of-international-clinical-practice-guidelines-in-kidney-transplantation-using-the-appraisal-of-guidelines-for-research-and-education-agree-ii-tool-a-systematic-review
#8
Katriona Jane Marie OʼDonoghue, Rhiannon D Reed, Simon R Knight, John M O'Callaghan, Anam A Ayaz-Shah, Sevda Hassan, Annemarie Weissenbacher, Peter J Morris, Liset H M Pengel
BACKGROUND: Whilst Clinical Practice Guidelines (CPGs) are used for the development of local protocols in kidney transplantation (Ktx), the quality of their methodology is variable. This systematic review aimed to critically appraise international CPGs in all aspects of Ktx using the Appraisal of Guidelines for Research and Evaluation (AGREE) II tool. METHODS: CPGs in Ktx and donation published between 2010 and 2017 were identified from MEDLINE, Embase, National Guideline Clearinghouse, NHS and NICE Evidence Searches, and the websites of transplant societies...
May 22, 2018: Transplantation
https://www.readbyqxmd.com/read/29786155/is-home-blood-pressure-monitoring-in-hypertensive-disorders-of-pregnancy-consistent-with-clinic-recordings
#9
Erkan Kalafat, Iffat Mir, Helen Perry, Basky Thilaganathan, Asma Khalil
OBJECTIVES: To assess the agreement of home blood-pressure monitoring (HBPM) and office blood pressure measurements in a cohort of pregnant women with Hypertensive Disorders of Pregnancy (HDP). METHODS: This was a cohort study at St George's Hospital, University of London conducted between years 2016 and 2017. The inclusion criteria were chronic hypertension, gestational hypertension or high risk of developing preeclampsia, no significant proteinuria and no hematological or biochemical abnormalities...
May 22, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29776383/escalate-adaptive-treatment-approach-for-adolescents-and-adults-with-adhd-study-protocol-for-a-randomized-controlled-trial
#10
Toivo Zinnow, Tobias Banaschewski, Andreas J Fallgatter, Carolin Jenkner, Florence Philipp-Wiegmann, Alexandra Philipsen, Wolfgang Retz, Esther Sobanski, Johannes Thome, Michael Rösler
BACKGROUND: Over the last decade, a wide range of attention-deficit/hyperactivity disorder (ADHD) treatment approaches for adults, including both pharmacological interventions and psychosocial treatments, have been proposed and observed to be efficient. In practice, individual treatment concepts are based on results of clinical studies as well as international guidelines (NICE Guidelines) that recommend a step-by-step treatment approach. Since the evidence supporting this approach is limited, the aim of the present study is to determine an optimal intervention regarding severity levels of ADHD symptomatology conducting a randomized controlled trial...
May 18, 2018: Trials
https://www.readbyqxmd.com/read/29754712/to-what-extent-do-clinical-practice-guidelines-respond-to-the-needs-and-preferences-of-patients-diagnosed-with-obsessive-compulsive-disorder
#11
Amelia Villena-Jimena, Clara Gómez-Ocaña, Gisela Amor-Mercado, Amanda Núñez-Vega, José Miguel Morales-Asencio, María Magdalena Hurtado
INTRODUCTION: The number of Clinical Practice Guidelines (CPG) to help in making clinical decisions is increasing. However, there is currently a lack of CPG for Obsessive-Compulsive Disorder that take into account the requirements and expectations of the patients. OBJECTIVE: The aim of the present study was to determine whether recommendations of the NICE guideline, "Obsessive-compulsive disorder: core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder" agrees with the needs and preferences of patients diagnosed with OCD in the mental health service...
April 2018: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29722491/-routine-preoperative-testing-in-adults-undergoing-elective-non-cardiothoracic-surgery
#12
REVIEW
N Benahmed, G Briat, K Rondia, J Vlayen
INTRODUCTION: The Belgian Health Care Knowledge Center (KCE) developed a guideline about routine preoperative testing in adults undergoing elective non-cardiothoracic surgery. The guideline is intended for all care providers involved in the preoperative and perioperative management (incl. anesthesiologists, surgeons, cardiologists, lung specialists, radiologists, clinical biologists, general practitioners, etc). METHOD: A recent English guideline published by NICE (National Institute for Health and Care Excellence) was used as a starting point and adapted to the Belgian context...
2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29722052/the-methodological-quality-of-guidelines-for-hospital-acquired-pneumonia-and-ventilator-associated-pneumonia-a-systematic-review
#13
REVIEW
R Ambaras Khan, Z Aziz
WHAT IS KNOWN AND OBJECTIVES: Clinical practice guidelines serve as a framework for physicians to make decisions and to support best practice for optimizing patient care. However, if the guidelines do not address all the important components of optimal care sufficiently, the quality and validity of the guidelines can be reduced. The objectives of this study were to systematically review current guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), evaluate their methodological quality and highlight the similarities and differences in their recommendations for empirical antibiotic and antibiotic de-escalation strategies...
May 2, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29664124/a-comparison-of-the-treatment-recommendations-for-neurogenic-lower-urinary-tract-dysfunction-in-the-national-institute-for-health-and-care-excellence-european-association-of-urology-and-international-consultations-on-incontinence-guidelines
#14
Ashley Jaggi, Marcus Drake, Emad Siddiqui, Francis Fatoye
AIMS: Healthcare guidelines are an important vehicle in establishing up-to-date evidence based medicine (EBM) in clinical practice. Due to varying development processes, clinical guidelines created by different institutions can often contain contrasting recommendations. This can have implications for optimal and standardized patient care across management settings. METHODS: The similarities and differences of treatment recommendations made in the National Institute for Health and Care Excellence (NICE), The European Association of Urology (EAU), and the International Consultation on Continence (ICI) guidelines for neurogenic lower urinary tract dysfunction (NLUTD) were assessed...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29656532/of-lamp-posts-keys-and-fabled-drunkards-a-perspectival-tale-of-4-guidelines
#15
Trisha Greenhalgh
BACKGROUND: Evidence-based medicine is the application of research findings to inform individual clinical decisions. There is a tension-both philosophical and practical-between the average result from a population study and the circumstances and needs of an individual patient. This personal account of "evidence-based" trauma care illustrates and explores this tension. THE CASE: The author, a keen athlete, describes her experience of a high-impact cycle accident that led to limb fractures (which were diagnosed and treated according to evidence-based guidelines) and also an occult injury to the cervical spine (which was not diagnosed at the time)...
April 15, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29650474/current-trends-in-the-medical-management-of-osteoradionecrosis-using-triple-therapy
#16
J Dhanda, L Rennie, R Shaw
Recent guidelines from the National Institute for Health and Care Excellence (NICE) have suggested that the medical management of osteoradionecrosis (ORN) of the jaws should be used in clinical trials only, and some drugs and therapeutics committees have withdrawn funds for such prescriptions. With increased scrutiny on the use of these agents, the aims of this study were to ascertain current trends in the presentation and management of ORN, with particular focus on which agents are being used.
June 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29645347/does-the-introduction-of-prostate-multiparametric-magnetic-resonance-imaging-into-the-active-surveillance-protocol-for-localized-prostate-cancer-improve-patient-re-classification
#17
Richard J Bryant, Bob Yang, Yiannis Philippou, Karla Lam, Maureen Obiakor, Jennifer Ayers, Virginia Chiocchia, Fergus Gleeson, Ruth MacPherson, Clare Verrill, Prasanna Sooriakumaran, Freddie C Hamdy, Simon F Brewster
OBJECTIVES: To determine whether replacement of protocol-driven repeat prostate biopsy (PB) with multiparametric magnetic resonance imaging (mpMRI) ± repeat targeted prostate biopsy (TB) when evaluating men on active surveillance (AS) for low-volume, low- to intermediate-risk prostate cancer (PCa) altered the likelihood of or time to treatment, or reduced the number of repeat biopsies required to trigger treatment. PATIENTS AND METHODS: A total of 445 patients underwent AS in the period 2010-2016 at our institution, with a median (interquartile range [IQR]) follow-up of 2...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29617060/prospective-real-world-analysis-of-onabotulinumtoxina-in-chronic-migraine-post-national-institute-for-health-and-care-excellence-uk-technology-appraisal
#18
A P Andreou, M Trimboli, A Al-Kaisy, M Murphy, S Palmisani, C Fenech, T Smith, G Lambru
BACKGROUND AND PURPOSE: The National Institute for Health and Care Excellence (NICE) in the UK recommends the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service. In view of the lack of data on the efficacy of this therapy following implementation of these guidelines in clinical practice and on the evaluation of guidance compliance, we aimed to evaluate the effectiveness and safety of BoNTA in patients with CM following the NICE guidelines...
April 4, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29591538/quality-measurement-recommendations-relevant-to-clinical-guidelines-in-germany-and-the-united-kingdom-what-can-we-learn-from-each-other
#19
Thomas Petzold, Stefanie Deckert, Paula R Williamson, Jochen Schmitt
We conducted a systematic review of clinical guidelines (CGs) to examine the methodological approaches of quality indicator derivation in CGs, the frequency of quality indicators to check CG recommendations in routine care, and clinimetric properties of quality indicators. We analyzed the publicly available CG databases of the Association of the Scientific Medical Societies in Germany (AWMF) and National Institute for Health and Care Excellence (NICE). Data on the methodology of subsequent quality indicator derivation, the content and definition of recommended quality indicators, and clinimetric properties of measurement instruments were extracted...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29568729/audit-of-physical-health-monitoring-in-children-and-adolescents-receiving-antipsychotics-in-neurodevelopmental-clinics-in-northumberland
#20
Sundar Gnanavel, Sharafat Hussain
AIM: To ascertain performance against the standards set by National Institute for Clinical Excellence (NICE) guidelines on physical health monitoring of thirty children and adolescents prescribed antipsychotics in neurodevelopmental clinics in Northumberland and identifying areas for improvement in practice. METHODS: The audit involved a review of recorded documentation pertaining to physical health monitoring in patient electronic records pertaining to children and adolescents attending neurodevelopmental clinics in Northumberland prescribed antipsychotics...
March 22, 2018: World Journal of Psychiatry
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