keyword
MENU ▼
Read by QxMD icon Read
search

Sucrase

keyword
https://www.readbyqxmd.com/read/29885400/biological-interaction-of-newly-synthesized-astaxanthin-s-allyl-cysteine-biconjugate-with-saccharomyces-cerevisiae-and-mammalian-%C3%AE-glucosidase-in-vitro-kinetics-and-in-silico-docking-analysis
#1
Sakayanathan Penislusshiyan, Loganathan Chitra, Iruthayaraj Ancy, Periyasamy Premkumar, Poomani Kumaradhas, Periasamy Viswanathamurthi, Thayumanavan Palvannan
In humans, alpha-glucosidase activity is present in sucrase-isomaltase (SI) and maltase-glucoamylase (MGAM). α-glucosidase is involved in the hydrolyses of disaccharide into monosaccharides and results in hyperglycemia. Subsequently chronic hyperglycemia induces oxidative stress and ultimately leads to the secondary complications of diabetes. Hence, identifying compounds with dual beneficial activity such as efficient antioxidant and α-glucosidase inhibition property has attracted the attention in recent years...
June 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29762381/13c-labeled-starch-breath-test-in-congenital-sucrase-isomaltase-deficiency
#2
Claudia C Robayo-Torres, Marisela Diaz-Sotomayor, Bruce R Hamaker, Susan S Baker, Bruno P Chumpitazi, Antone R Opekun, Buford L Nichols
BACKGROUND AND HYPOTHESES: Human starch digestion is a multienzyme process involving 6 different enzymes: salivary and pancreatic α-amylase; sucrase and isomaltase (from sucrose-isomaltase [SI]), and maltase and glucoamylase (from maltase-glucoamylase [MGAM]). Together these enzymes cleave starch to smaller molecules ultimately resulting in the absorbable monosaccharide glucose. Approximately 80% of all mucosal maltase activity is accounted for by SI and the reminder by MGAM. Clinical studies suggest that starch may be poorly digested in those with congenital sucrase-isomaltase deficiency (CSID)...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762380/clinical-characteristics-of-disaccharidase-deficiencies-among-children-undergoing-upper-endoscopy
#3
Stanley A Cohen, Hannah Oloyede, Benjamin D Gold, Aminu Mohammed, Heather E Elser
OBJECTIVES: The epidemiology and clinical significance of disaccharidase deficiencies have not been thoroughly characterized. Recent work suggests at least genetic sucrase-isomaltase deficiency is more prevalent than previously believed. Because lactase deficiency (LD) is well described, the present study focuses on the clinical characteristics of children with disaccharidase deficiencies determined by esophagogastroduodenoscopy. METHODS: Endoscopic records were reviewed from patients undergoing esophagogastroduodenoscopies with biopsies assayed for disaccharidase activity performed by 13 pediatric gastroenterologists during 5 years (2010-2014)...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762372/metabolic-impacts-of-maltase-deficiencies
#4
Buford L Nichols, Susan S Baker, Roberto Quezada-Calvillo
The mucosal maltase enzymes are characterized by an activity that produces glucose from linear glucose polymers, assayed with the disaccharide maltose. The related enzyme isomaltase produces glucose from branched glucose polymers, assayed with palatinose. Maltase and isomaltase activities are part of the 4 disaccharidases assayed from clinical duodenal biopsy homogenates. The reported maltase activities are more difficult to interpret than lactase or sucrase activities because both the sucrase-isomaltase and maltase-glucoamylase proteins have overlapping maltase activities...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762371/posttranslational-processing-and-function-of-mucosal-maltases
#5
Mahdi Amiri, Hassan Y Naim
The final step of carbohydrate digestion in the intestine is performed by 2 major α-glucosidases of the intestinal mucosa, sucrase-isomaltase (SI) and maltase-glucoamylase. Both of these enzymes are type II membrane glycoproteins, which share a significant level of homology in gene and protein structures and yet have differences in the posttranslational processing, substrate specificity and functional capacity. Insufficient activity of these disaccharidases particularly SI as a result of genetic mutations or secondary intestinal pathologies is associated with carbohydrate maldigestion and gastrointestinal intolerances...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762370/molecular-regulations-of-mucosal-maltase-expressions
#6
Toshinao Goda, Kazue Honma
Two major α-glucosidase (maltase) genes, sucrase-isomaltase (SI) and maltase-glucoamylase (MGAM), respectively, are expressed in the small intestine. In this review, we have summarized whether jejunal expression of these maltase genes is regulated by dietary manipulations, which may affect carbohydrate availability from the luminal side, through changes in the binding of transcription factors and/or histone code on these genes. Studies using a model of mice fed either a low-starch or a high-starch diet for 7 days, found the mRNA levels of SI, MGAM, and Na-glucose cotransporter (SGLT1) genes in the jejunum to be increased in parallel by feeding a high-starch diet...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762369/structural-studies-of-the-intestinal-%C3%AE-glucosidases-maltase-glucoamylase-and-sucrase-isomaltase
#7
David R Rose, Marcia M Chaudet, Kyra Jones
OBJECTIVES: Maltase-glucoamylase and sucrase-isomaltase are enzymes in the brush-border membrane of the small intestinal lumen responsible for the breakdown of postamylase starch polysaccharides to release monomeric glucose. As such, they are critical players in healthy nutrition and their malfunction can lead to severe disorders. METHODS: This review covers investigations of the structures and functions of these enzymes. RESULTS: Each consists of 2 enzyme domains of the glycoside hydrolase family GH31 classification, yet with somewhat differing enzymatic properties...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762368/maltase-has-most-versatile-%C3%AE-hydrolytic-activity-among-the-mucosal-%C3%AE-glucosidases-of-the-small-intestine
#8
Byung-Hoo Lee, Bruce R Hamaker
Complete digestion of the glycemic carbohydrates to glucose takes place through the combined action of the 4 mucosal α-glucosidases (maltase-glucoamylase and sucrase-isomaltase) in the small intestine. Maltase digests α-1,2- and α-1,3-disaccharides better than the other α-glucosidases, and has, as well, the capability to effectively hydrolyze α-1,4 and α-1,6 linkages that form the major backbone of a starch molecule. This broad hydrolytic activity on α-linkages makes it an enzyme that has the most versatile α-hydrolytic activity among the 4mucosal α-glucosidases...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29762367/the-history-of-maltose-active-disaccharidases
#9
Michael J Lentze
The history of maltose-active disaccharidases is closely related to the history of the sugar and starch industry. It began in the 19th century, when a shortage of cane sugar occurred in continental Europe, because Napoleon Bonaparte decreed that no goods could be imported from England to the countries he occupied. Other sugar sources had to be found, and it led to the identification of sugar beets as alternative source of sugar by Marggraf in 1774, to the detection of starch hydrolysis by diluted sulfuric acid by Kirchhoff in 1812, and to the starch digestion enzyme, α-amylase, by Payen in 1833...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29761590/the-interaction-of-anti-diabetic-%C3%AE-glucosidase-inhibitors-and-gut-bacteria-%C3%AE-glucosidase
#10
Kemin Tan, Christine Tesar, Rosemarie Wilton, Robert P Jedrzejczak, Andrzej Joachimiak
Carbohydrate hydrolyzing α-glucosidases are commonly found in microorganisms present in the human intestine microbiome. We have previously reported crystal structures of an α-glucosidase from the human gut bacterium Blaubia (Ruminococcus) obeum (Ro-αG1) and its substrate preference/specificity switch. This novel member of the GH31 family is a structural homolog of human intestinal maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) with a highly conserved active site that is predicted to be common in Ro-αG1 homologs among other species that colonize the human gut...
May 15, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29722232/-effects-of-exogenous-spermidine-and-arbuscular-mycorrhizal-fungi-on-plant-growth-of-cucumber
#11
Ya Sheng Wu, Shi Rong Guo, Jie Zhang, Nan Shan Du, Jin Sun
Effects of spermidine (Spd) and arbuscular mycorrhizal fungi (AMF) on the growth and photosynthesis of cucumber (Cucumis sativus L., cv. Jinchun 2) seedlings, fruit yield and quality, microorganism and enzymatic activity in rhizosphere were investigated. The results showed that combined Spd and AMF addition significantly promoted the growth of cucumber seedlings, increased the root activity, fruit production and quality, enhanced nutrients absorption of seedlings. Net photosynthetic rate, actual photochemical efficiency, light quantum efficiency, carboxylation efficiency and light respiration rate of cucumber seedlings were increased by combined addition of Spd and AMF...
March 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29715699/effect-of-gestational-and-lactational-exposure-to-dehp-dinp-and-dep-on-intestinal-morphology-disaccharidases-and-alkaline-phosphatase-in-rats-during-postnatal-development
#12
K Setti Ahmed, O Kharoubi, A E K Aoues, M Bouchekara, B Khaladi, M Taleb
INTRODUCTION:  The diesters of 1,2-benzenedicarboxylic acid (phthalic acid), commonly known as phthalates, are used primarily as plasticizers of polyvinyl chloride and as additives in consumer and personal care products. OBJECTIVE:  This study was designed to evaluate the impact of in utero and postnatal exposure to diisononyl phthalate (DINP), diethylhexyl phthalate (DEHP), and diethyl phthalate (DEP) on gut maturation in a Wistar rat model. MATERIALS AND METHODS:  Pregnant females were gavaged from day 8 of gestation through postnatal day (pd) 30 with 0 (vehicle control), DEHP (380 mg/kg/d), DINP (380 mg/kg/d), or DEP (800 mg/kg/d) dissolved in corn oil...
May 1, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29710469/hydroxytyrosol-nicotinate-a-new-multifunctional-hypolipidemic-and-hypoglycemic-agent
#13
Yun-Dong Xie, Zi-Zhang Chen, Na Li, Wen-Fang Lu, Yan-Hong Xu, Yuan-Yuan Lin, Li-Hua Shao, Qiu-Tang Wang, Li-Ying Guo, Yu-Qiong Gao, Guang-De Yang, Yi-Ping Li, Xiao-Li Bian
Hydroxytyrosol (HT) is a natural polyphenol antioxidant that exists in olive oil. In the study of multifunctional hypolipidemic of nicotinic derivatives, we found that hydroxytyrosol nicotinate (HT-N) incorporation of niacin with HT displayed ?-glucosidase inhibitory activities in vitro, such as yeast ?-glucosidase (IC50 ?=?117.72??M) and rat intestinal ?-glucosidases maltase (IC50 ?=?31.86??M) and sucrase (IC50 ?=?22.99??M), and had a good control of postprandial blood glucose (PBG). HT-N shown significantly hypoglycemic action by 16...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29701065/total-synthesis-of-natural-hyacinthacine-c-5-and-six-related-hyacinthacine-c-5-epimers
#14
Anthony W Carroll, Kongdech Savaspun, Anthony C Willis, Masako Hoshino, Atsushi Kato, Stephen G Pyne
The total synthesis of natural (+)-hyacinthacine C5 was achieved, which allowed correction of its initially proposed structure, as well as six additional hyacinthacine C-type compounds. These compounds were readily accessible from two epimeric anti-1,2-amino alcohols. Keeping a common A-ring configuration, chemical manipulation occurred selectively on the B-ring of the hyacinthacine C-type products through methods of syn-dihydroxylation, SN 2 ring-opening of a cyclic sulfate, and also employing either ( R)- or ( R, S)-α-methylallyl amine for the Petasis borono Mannich reaction...
May 18, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29660731/remediation-of-multiple-heavy-metal-contaminated-soil-through-the-combination-of-soil-washing-and-in-situ-immobilization
#15
Xiuqing Zhai, Zhongwu Li, Bin Huang, Ninglin Luo, Mei Huang, Qiu Zhang, Guangming Zeng
The remediation of heavy metal-contaminated soils is a great challenge for global environmental sciences and engineering. To control the ecological risks of heavy metal-contaminated soil more effectively, the present study focused on the combination of soil washing (with FeCl3 ) and in situ immobilization (with lime, biochar, and black carbon). The results showed that the removal rate of Cd, Pb, Zn, and Cu was 62.9%, 52.1%, 30.0%, and 16.7%, respectively, when washed with FeCl3 . After the combined remediation (immobilization with 1% (w/w) lime), the contaminated soils showed 36...
September 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660529/bmsuc1-is-essential-for-glycometabolism-modulation-in-the-silkworm-bombyx-mori
#16
Quan Gan, Xinwei Zhang, Daobo Zhang, Liang Shi, Yue Zhou, Tongtong Sun, Song Jiang, Junshan Gao, Yan Meng
Sucrose is the most commonly transported sugar in plants and is easily assimilated by insects to fulfill the requirement of physiological metabolism. BmSuc1 is a novel animal β-fructofuranosidase (β-FFase, EC 3.2.1.26)-encoding gene that was firstly cloned and identified in silkworm, Bombyx mori. BmSUC1 was presumed to play an important role in the silkworm-mulberry enzymatic adaptation system by effectively hydrolyzing sucrose absorbed from mulberry leaves. However, this has not been proved with direct evidence thus far...
June 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29562339/dietary-chlorogenic-acid-improves-growth-performance-of-weaned-pigs-through-maintaining-antioxidant-capacity-and-intestinal-digestion-and-absorption-function
#17
Jiali Chen, Yan Li, Bing Yu, Daiwen Chen, Xiangbing Mao, Ping Zheng, Junqiu Luo, Jun He
Chlorogenic acid (CGA) is a natural phenolic acid, which is an important component of biologically active dietary phenols isolated from various species. Two experiments were conducted to investigate the effects of CGA on growth performance, antioxidant capacity, nutrient digestibility, diarrhea incidence, intestinal digestion and absorption function, and the expression levels of intestinal digestion and absorption-related genes in weaned pigs. In Exp. 1, 200 weaned pigs were randomly allotted to four dietary treatments and fed with a basal diet or a basal diet supplemented with 250, 500, or 1,000 mg/kg CGA, respectively, in a 14-d trial...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29550680/effect-of-different-dietary-non-starch-fiber-fractions-on-growth-performance-nutrient-digestibility-and-intestinal-development-in-weaned-pigs
#18
Xiying Wu, Daiwen Chen, Bing Yu, Yuheng Luo, Ping Zheng, Xiangbing Mao, Jie Yu, Jun He
OBJECTIVES: This study explored the effects of different fiber fractions on growth performance, nutrient digestibility and intestinal development in a porcine model. METHODS: Blood and tissue samples were collected from thirty-two weaned pigs fed with control diet (CON) or diet containing 5 % cellulose (CEL), xylan (XYL) or β-glucan (GLU). RESULTS: This reserch showed that GLU supplementation decreased the growth performance of pigs (P <0...
July 2018: Nutrition
https://www.readbyqxmd.com/read/29543768/calorie-restriction-effect-of-heat-processed-onion-extract-oni-using-in-vitro-and-in-vivo-animal-models
#19
Yu-Ri Kang, Hwang-Yong Choi, Jung-Yun Lee, Soo In Jang, Hanna Kang, Jung-Bae Oh, Hae-Dong Jang, Young-In Kwon
Onion ( Allium cepa L.) is widely consumed as food or medicinal plant due to its well-defined health benefits. The antioxidant and antihyperlipidemic effects of onion and its extracts have been reported well. However, very limited information on anti-hyperglycemic effect is available in processed onion extracts. In our previous study, we reported that Amadori rearrangement compounds (ARCs) produced by heat-processing in Korean ginseng can reduce carbohydrate absorption by inhibiting intestinal carbohydrate hydrolyzing enzymes in both in vitro and in vivo animal models...
March 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29524000/nutritional-implications-of-olives-and-sugar-attenuation-of-post-prandial-glucose-spikes-in-healthy-volunteers-by-inhibition-of-sucrose-hydrolysis-and-glucose-transport-by-oleuropein
#20
Asimina Kerimi, Hilda Nyambe-Silavwe, Alison Pyner, Ebun Oladele, Julia S Gauer, Yala Stevens, Gary Williamson
PURPOSE: The secoiridoid oleuropein, as found in olives and olive leaves, modulates some biomarkers of diabetes risk in vivo. A possible mechanism may be to attenuate sugar digestion and absorption. METHODS: We explored the potential of oleuropein, prepared from olive leaves in a water soluble form (OLE), to inhibit digestive enzymes (α-amylase, maltase, sucrase), and lower [14 C(U)]-glucose uptake in Xenopus oocytes expressing human GLUT2 and [14 C(U)]-glucose transport across differentiated Caco-2 cell monolayers...
March 9, 2018: European Journal of Nutrition
keyword
keyword
18485
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"