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https://www.readbyqxmd.com/read/29676967/municipal-solid-waste-generation-and-disposal-in-robe-town-ethiopia
#1
Duguma Erasu, Tesfaye Faye, Amaha Kiros, Abel Balew
The amount of solid waste generated in developing countries is rising from time to time due to economic growth, change in consumer behavior and lifestyles of people. But it is hard to manage and handle the increase of solid waste with existing waste management infrastructure. Thus, the management system of solid waste is very poor and become a serious problem. The main purpose of this study is to quantify the volume of solid waste generated and investigate factors affecting generation and disposal of wastes in the study area...
April 20, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29676680/midline-central-fluid-percussion-model-of-traumatic-brain-injury-in-pediatric-and-adolescent-rats
#2
Rachel K Rowe, Jordan L Harrison, Timothy W Ellis, P David Adelson, Jonathan Lifshitz
OBJECTIVE Experimental traumatic brain injury (TBI) models hold significant validity to the human condition, with each model replicating a subset of clinical features and symptoms. TBI is the leading cause of mortality and morbidity in children and teenagers; thus, it is critical to develop preclinical models of these ages to test emerging treatments. Midline fluid percussion injury (FPI) might best represent mild and diffuse clinical brain injury because of the acute behavioral deficits, the late onset of behavioral morbidities, and the absence of gross histopathology...
April 20, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29674985/dog-owner-attachment-is-associated-with-oxytocin-receptor-gene-polymorphisms-in-both-parties-a-comparative-study-on-austrian-and-hungarian-border-collies
#3
Krisztina Kovács, Zsófia Virányi, Anna Kis, Borbála Turcsán, Ágnes Hudecz, Maria T Marmota, Dóra Koller, Zsolt Rónai, Márta Gácsi, József Topál
Variations in human infants' attachment behavior are associated with single nucleotide polymorphisms (SNPs) in the oxytocin receptor (OXTR) gene, suggesting a genetic component to infant-mother attachment. However, due to the genetic relatedness of infants and their mothers, it is difficult to separate the genetic effects of infants' OXTR genotype from the environmental effects of mothers' genotype possibly affecting their parental behavior. The apparent functional analogy between child-parent and dog-owner relationship, however, offers a way to disentangle the effects of these factors because pet dogs are not genetically related to their caregivers...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674983/is-there-a-conjunction-fallacy-in-legal-probabilistic-decision-making
#4
Bartosz W Wojciechowski, Emmanuel M Pothos
Classical probability theory (CPT) has represented the rational standard for decision making in human cognition. Even though CPT has provided many descriptively excellent decision models, there have also been some empirical results persistently problematic for CPT accounts. The tension between the normative prescription of CPT and human behavior is particularly acute in cases where we have higher expectations for rational decisions. One such case concerns legal decision making from legal experts, such as attorneys and prosecutors and, more so, judges...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674980/decision-making-in-suicidal-behavior-the-protective-role-of-loss-aversion
#5
Gergö Hadlaczky, Sebastian Hökby, Anahit Mkrtchian, Danuta Wasserman, Judit Balazs, Núria Machín, Marco Sarchiapone, Merike Sisask, Vladimir Carli
Background: Loss aversion is a central and well operationalized trait behavior that describes the tendency for humans to strongly prefer avoiding losses to making equivalent gains. Human decision-making is thus biased toward safer choices. Aim: The aim of this study was to explore the relationship between loss aversion and suicidal behavior in a large cohort of adolescents recruited in 30 schools of seven European countries for a longitudinal study (Current Controlled Trials ISRCTN65120704)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29674817/evaluation-of-retention-and-fracture-resistance-of-different-fiber-reinforced-posts-an-in-vitro-study
#6
Varun Pruthi, Sangeeta Talwar, Ruchika Roongta Nawal, Preeti Jain Pruthi, Sarika Choudhary, Seema Yadav
Aim: The aim of this study was to evaluate retention & fracture resistance of different fibre posts. Methodology: 90 extracted human permanent maxillary central incisors were used in this study. For retention evaluation, after obturation, post space preparation was done in all root canals and posts were cemented under three groups. Later, the posts were grasped & pulled out from the roots with the help of a three-jaw chuck at a cross-head speed of 5mm/min...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29674112/cadherin-profiling-for-therapeutic-interventions-in-epithelial-mesenchymal-transition-emt-and-tumorigenesis
#7
REVIEW
Mintu Pal, Sourya Bhattacharya, Gazal Kalyan, Saugata Hazra
The major hallmarks of Epithelial-Mesenchymal Transition (EMT) is the loss of epithelial cell polarity and loss of expression of the cell- cell adhesion molecule like E-cadherin and acquired mesenchymal cells marker called N-Cadherin. This phenotypical changes of E-M plasticity of cells is extensively considered to be a crucial factor for tumor cells invasion and cancer metastasis; landmark events for transforming a locally growing tumor (benign tumor) into a systemic and live-threatening disease (malignant tumor)...
April 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29673930/amelioration-of-neurosensory-structure-and-function-in-animal-and-cellular-models-of-a-congenital-blindness
#8
Ji Yun Song, Puya Aravand, Sergei Nikonov, Lanfranco Leo, Arkady Lyubarsky, Jeannette L Bennicelli, Jieyan Pan, Zhangyong Wei, Ivan Shpylchak, Pamela Herrera, Daniel J Bennett, Nicoletta Commins, Albert M Maguire, Jennifer Pham, Anneke I den Hollander, Frans P M Cremers, Robert K Koenekoop, Ronald Roepman, Patsy Nishina, Shangzhen Zhou, Wei Pan, Gui-Shuang Ying, Tomas S Aleman, Jimmy de Melo, Ilan McNamara, Junwei Sun, Jason Mills, Jean Bennett
Most genetically distinct inherited retinal degenerations are primary photoreceptor degenerations. We selected a severe early onset form of Leber congenital amaurosis (LCA), caused by mutations in the gene LCA5, in order to test the efficacy of gene augmentation therapy for a ciliopathy. The LCA5-encoded protein, Lebercilin, is essential for the trafficking of proteins and vesicles to the photoreceptor outer segment. Using the AAV serotype AAV7m8 to deliver a human LCA5 cDNA into an Lca5 null mouse model of LCA5, we show partial rescue of retinal structure and visual function...
March 21, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29673843/circulating-corticosterone-levels-vary-during-exposure-to-anthropogenic-stimuli-and-show-weak-correlation-with-behavior-across-an-urban-gradient-in-house-finches-haemorhous-mexicanus
#9
Melinda Weaver, Sisi Gao, Kevin J McGraw
Urban environments are rapidly expanding and presenting animal populations with novel challenges, many of which are thought to be stressors that contribute to low biodiversity. However, studies on stress responses in urban vs rural populations have produced mixed results, and many of these studies use a standard stressor that cannot be replicated in the wild (e.g. restraining an animal in a bag). Pairing physiological and behavioral measurements in response to urban-related stressors improves our understanding of the mechanism underlying animal success in human-dominated landscapes...
April 16, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29673714/discovery-and-evaluation-of-nna-v-1-5-sodium-channel-blockers-with-potent-cell-invasion-inhibitory-activity-in-breast-cancer-cells
#10
Shilpa Dutta, Osbaldo Lopez Charcas, Samuel Tanner, Frédéric Gradek, Virginie Driffort, Sébastien Roger, Katri Selander, Sadanandan E Velu, Wayne Brouillette
Voltage-gated sodium channels (VGSC) are a well-established drug target for anti-epileptic, anti-arrhythmic and pain medications due to their presence and the important roles that they play in excitable cells. Recently, their presence has been recognized in non-excitable cells such as cancer cells and their overexpression has been shown to be associated with metastatic behavior in a variety of human cancers. The neonatal isoform of the VGSC subtype, Nav 1.5 (nNav 1.5) is overexpressed in the highly aggressive human breast cancer cell line, MDA-MB-231...
April 3, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29673576/the-role-of-genetic-variation-of-human-metabolism-for-bmi-mental-traits-and-mental-disorders
#11
Johannes Hebebrand, Triinu Peters, Dick Schijven, Moritz Hebebrand, Corinna Grasemann, Thomas W Winkler, Iris M Heid, Jochen Antel, Manuel Föcker, Lisa Tegeler, Lena Brauner, Roger A H Adan, Jurjen J Luykx, Christoph U Correll, Inke R König, Anke Hinney, Lars Libuda
OBJECTIVE: The aim was to assess whether loci associated with metabolic traits also have a significant role in BMI and mental traits/disorders METHODS: We first assessed the number of single nucleotide polymorphisms (SNPs) with genome-wide significance for human metabolism (NHGRI-EBI Catalog). These 516 SNPs (216 independent loci) were looked-up in genome-wide association studies for association with body mass index (BMI) and the mental traits/disorders educational attainment, neuroticism, schizophrenia, well-being, anxiety, depressive symptoms, major depressive disorder, autism-spectrum disorder, attention-deficit/hyperactivity disorder, Alzheimer's disease, bipolar disorder, aggressive behavior, and internalizing problems...
April 3, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29673529/neurochemistry-of-anesthetic-states
#12
Ralph Lydic, Helen A Baghdoyan, Amanda L May
Anesthetic mechanisms that eliminate consciousness and perception of pain are products of the nervous system. Chemical approaches to the study of anesthetic mechanisms have the potential to serve as an ideal interface between basic and clinical neuroscience. There are disproportionately more basic neurochemical studies than clinical studies of anesthetic mechanisms. Even within neuroscience, the study of anesthetic mechanisms is sparse. The Society for Neuroscience hosts one of the world's largest and most vibrant scientific meetings, yet the content themes of that meeting do not include anesthesia...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29673485/functional-brain-networks-are-dominated-by-stable-group-and-individual-factors-not-cognitive-or-daily-variation
#13
Caterina Gratton, Timothy O Laumann, Ashley N Nielsen, Deanna J Greene, Evan M Gordon, Adrian W Gilmore, Steven M Nelson, Rebecca S Coalson, Abraham Z Snyder, Bradley L Schlaggar, Nico U F Dosenbach, Steven E Petersen
The organization of human brain networks can be measured by capturing correlated brain activity with fMRI. There is considerable interest in understanding how brain networks vary across individuals or neuropsychiatric populations or are altered during the performance of specific behaviors. However, the plausibility and validity of such measurements is dependent on the extent to which functional networks are stable over time or are state dependent. We analyzed data from nine high-quality, highly sampled individuals to parse the magnitude and anatomical distribution of network variability across subjects, sessions, and tasks...
April 18, 2018: Neuron
https://www.readbyqxmd.com/read/29673366/improving-cytocompatibility-of-cdte-quantum-dots-by-schiff-base-coordinated-lanthanides-surface-doping
#14
Hana Buchtelova, Vladislav Strmiska, Zuzana Skubalova, Simona Dostalova, Petr Michalek, Sona Krizkova, David Hynek, Lukas Kalina, Lukas Richtera, Amitava Moulick, Vojtech Adam, Zbynek Heger
BACKGROUND: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable toxicity. This hinders QDs applicability in living systems. Surface chemistry has a profound impact on biological behavior of QDs. This study describes a two-step synthesis of QDs formed by CdTe core doped with Schiff base ligand for lanthanides [Ln (Yb3+ , Tb3+ and Gd3+ )] as novel cytocompatible fluorophores...
April 19, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29673295/gut-microbiota-metabolism-and-psychopathology-a-critical-review-and-novel-perspectives
#15
Robin N Groen, Nicolien C de Clercq, Max Nieuwdorp, H J Rogier Hoenders, Albert K Groen
Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function...
April 20, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29673140/euthanasia-of-cattle-practical-considerations-and-application
#16
REVIEW
Jan Keith Shearer
Acceptable methods for the euthanasia of cattle include overdose of an anesthetic, gunshot and captive bolt. The use of anesthetics for euthanasia is costly and complicates carcass disposal. These issues can be avoided by use of a physical method such as gunshot or captive bolt; however, each requires that certain conditions be met to assure an immediate loss of consciousness and death. For example, the caliber of firearm and type of bullet are important considerations when gunshot is used. When captive bolt is used, a penetrating captive bolt loaded with the appropriate powder charge and accompanied by a follow up (adjunctive) step to assure death are required...
April 17, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29672538/spatio-temporal-patterns-of-attacks-on-human-and-economic-losses-from-wildlife-in-chitwan-national-park-nepal
#17
Babu Ram Lamichhane, Gerard A Persoon, Herwig Leirs, Shashank Poudel, Naresh Subedi, Chiranjibi Prasad Pokheral, Santosh Bhattarai, Bishnu Prasad Thapaliya, Hans H de Iongh
Wildlife attacks on humans and economic losses often result in reduced support of local communities for wildlife conservation. Information on spatial and temporal patterns of such losses in the highly affected areas contribute in designing and implementing effective mitigation measures. We analyzed the loss of humans, livestock and property caused by wildlife during 1998 to 2016, using victim family's reports to Chitwan National Park authorities and Buffer Zone User Committees. A total of 4,014 incidents were recorded including attacks on humans, livestock depredation, property damage and crop raiding caused by 12 wildlife species...
2018: PloS One
https://www.readbyqxmd.com/read/29672475/suicidal-ideation-and-attempts-among-students-in-grades-8-10-and-12-utah-2015
#18
Marissa L Zwald, Francis B Annor, Amanda Wilkinson, Mike Friedrichs, Anna Fondario, Angela C Dunn, Allyn Nakashima, Leah K Gilbert, Asha Ivey-Stephenson
Suicidal thoughts and behaviors among youths are important public health concerns in Utah, where the suicide rate among youths consistently exceeds the national rate and has been increasing for nearly a decade (1). In March 2017, CDC was invited to assist the Utah Department of Health (UDOH) with an investigation to characterize the epidemiology of fatal and nonfatal suicidal behaviors and identify risk and protective factors associated with these behaviors, among youths aged 10-17 years. This report presents findings related to nonfatal suicidal behaviors among Utah youths...
April 20, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29672181/pilates-physical-activity-and-diet-survey-an-italian-self-administered-questionnaire-evaluating-diet-habits-of-gym-goers-validation-process
#19
Vincenza Gianfredi, Daniele Nucci, Francesco Ceccarelli, Milena Villarini, Massimo Moretti
PILATES study aims are to assess the main characteristics related to food habits, diet behaviors, and nutrition knowledge and how and where gym-goers get information on dietary supplementation. We present evidence for the reliability, feasibility, and construct validity of the PILATES questionnaire. Cohen's kappa statistic (k) for dichotomous variables was used to assess the agreement between the two administrations (interrater agreement). The nutrient composition and energy of food were derived from the Food Composition Database for Epidemiological Studies in Italy (Banca Dati di Composizione degli Alimenti per Studi Epidemiologici in Italia - BDA)...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29672090/subjective-cannabis-effects-as-part-of-a-developing-disorder-in-adolescents-and-emerging-adults
#20
Hayley Treloar Padovano, Robert Miranda
In light of expanding legalization of cannabis and swelling debate about the potential risks, particularly for younger users, understanding acute cannabis effects among adolescents and emerging adults is more important than ever. Contemporary models of addiction development identify subjective drug responses as central to the developmental unfolding of drug use disorders. Despite this, surprisingly little is known about cannabis's acute subjective effects in human youths. This research utilized ecological momentary assessment (EMA) in the natural environment to identify the typical situational context of cannabis use among 85 frequent cannabis users, ages 15-24 years (M = 19...
April 2018: Journal of Abnormal Psychology
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