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https://www.readbyqxmd.com/read/29906703/modulation-of-serum-albumin-protein-corona-for-exploring-cellular-behaviors-of-fattigation-platform-nanoparticles
#1
Van Hong Nguyen, Nilesh M Meghani, Hardik H Amin, Thao T D Tran, Phuong H L Tran, Chulhun Park, Beom-Jin Lee
Albumin is the most abundant protein in blood, and is the most frequently identified protein in the protein corona of nanoparticles (NPs). Thus, albumin plays an important role in modulating NPs' physicochemical properties and bioavailability. In this study, the effect of bovine serum albumin (BSA) on gelatin-oleic nanoparticles' (GONs) physicochemical properties and cellular uptake were evaluated. Coumarin-6 was used as indicator to track the cellular uptake of GONs. The binding of BSA onto the GON surface increased the size, slightly reduced the negative net charge of the GON, and improved GON stability...
May 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29906633/graph-theoretical-modeling-of-baby-brain-networks
#2
REVIEW
Tengda Zhao, Yuehua Xu, Yong He
The human brain undergoes explosive growth during the prenatal period and the first few postnatal years, establishing an early infrastructure for the later development of behaviors and cognitions. Revealing the developmental rules during the early phrase is essential in understanding the emergence of brain function and the origin of developmental disorders. The graph-theoretical network modeling in combination with multiple neuroimaging probes provides an important research framework to explore early development of the topological wiring and organizational paradigms of the brain...
June 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29906410/polyamine-regulator-amd1-promotes-cell-migration-in-epidermal-wound-healing
#3
Lim Hui Kheng, Anisa B Rahim, Vonny Ivon Leo, Das Shatarupa, Thiam Chye Lim, Takeshi Uemura, Kazuei Igarashi, John Common, Leah A Vardy
Wound healing is a dynamic process involving gene-expression changes that drive re-epithelialization. Here, we describe an essential role for polyamine regulator, AMD1 in driving cell migration at the wound edge. The polyamines, putrescine, spermidine and spermine are small cationic molecules that play essential roles in many cellular processes. We demonstrate that AMD1, is rapidly upregulated following wounding in human skin biopsies. Knockdown of AMD1 with shRNAs causes a delay in cell migration that is rescued by the addition of spermine...
June 12, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29906283/classification-of-red-blood-cell-shapes-in-flow-using-outlier-tolerant-machine-learning
#4
Alexander Kihm, Lars Kaestner, Christian Wagner, Stephan Quint
The manual evaluation, classification and counting of biological objects demands for an enormous expenditure of time and subjective human input may be a source of error. Investigating the shape of red blood cells (RBCs) in microcapillary Poiseuille flow, we overcome this drawback by introducing a convolutional neural regression network for an automatic, outlier tolerant shape classification. From our experiments we expect two stable geometries: the so-called 'slipper' and 'croissant' shapes depending on the prevailing flow conditions and the cell-intrinsic parameters...
June 15, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29906097/a-facile-approach-for-the-doxorubicine-delivery-in-cancer-cells-by-responsive-and-fluorescent-core-shell-quantum-dots
#5
Enaam Jamal Al Dine, Sophie Marchal, Raphaël Schneider, Batoul Hamie, Jaafar Ghanbaja, Thibault Roques-Carmes, Tayssir Hamieh, Joumana Toufaily, Eric Gaffet, Halima Alem
Biocompatible thermo-responsive copolymers based on 2-(2-methoxyethoxy) ethyl methacrylate (MEO2MA) and oligo (ethylene glycol) methacrylate (OEGMA) were grown from the surface of ZnO Quantum Dots (QDs) by Surface Initiated Atom Transfer Radical Polymerization with Activators Regenerated by electron Transfer (SI-ARGET ATRP) in order to design smart and fluorescent core/shell nanosystems to be used towards cancer cells. Tunable lower critical solution temperature (LCST) values were obtained and studied in water and in culture medium...
June 15, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29905584/human-papilloma-virus-and-the-nurse-s-role-in-education-and-prevention
#6
Jennifer S Sherry, Sandra K Collins, Richard C McKinnies, Anthony Fleege, Marcea L Walter
In the United States, an estimated 20 million people, or 15% of the population, are currently infected with human papilloma virus (HPV). The prevalence of HPV is increasing in females aged 14 to 24 years. Assessing allied health students' knowledge, attitudes, and behaviors regarding HPV was performed using a 34-question survey. The survey was in four sections: general information, measuring knowledge of HPV and the vaccine, HPV vaccine, and HPV screening and diagnosis. Physicians were noted by 31.6% of the participants as the first individual who gave them information about HPV...
June 14, 2018: Health Care Manager
https://www.readbyqxmd.com/read/29905125/treatment-of-amblyopia-as-a-function-of-age
#7
Jonathan M Holmes, Dennis M Levi
Although historically, treatment of amblyopia has been recommended prior to closure of a critical window in visual development, the existence and duration of that critical window is currently unclear. Moreover, there is clear evidence, both from animal and human studies of deprivation amblyopia, that there are different critical windows for different visual functions and that monocular and binocular deprivation have different neural and behavioral consequences. In view of the spectrum of critical windows for different visual functions and for different types of amblyopia, combined with individual variability in these windows, treatment of amblyopia has been increasingly offered to older children and adults...
January 2018: Visual Neuroscience
https://www.readbyqxmd.com/read/29904929/role-of-first-year-maternal-employment-and-paternal-involvement-in-behavioral-and-cognitive-development-of-young-children
#8
Youngjo Im, Tyler J Vanderweele
Drawing on economic models of child development and attachment relationship perspectives, this study examined the effect of maternal employment in the first year after childbirth on subsequent behavioral and cognitive development in low-income children. Analyses of data from the Project on Human Development in Chicago Neighborhoods (N = 411) revealed that despite the accompanying family income gains, maternal employment in the first year after childbirth adversely affected caregiver-reported internalizing and externalizing behavior problems of Hispanic, Black, and White children at ages 3 and 5 years...
June 15, 2018: Infant Mental Health Journal
https://www.readbyqxmd.com/read/29904791/weighted-integration-of-short-term-memory-and-sensory-signals-in-the-oculomotor-system
#9
Nicolas Deravet, Gunnar Blohm, Jean-Jacques Orban de Xivry, Philippe Lefèvre
Oculomotor behaviors integrate sensory and prior information to overcome sensory-motor delays and noise. After much debate about this process, reliability-based integration has recently been proposed and several models of smooth pursuit now include recurrent Bayesian integration or Kalman filtering. However, there is a lack of behavioral evidence in humans supporting these theoretical predictions. Here, we independently manipulated the reliability of visual and prior information in a smooth pursuit task. Our results show that both smooth pursuit eye velocity and catch-up saccade amplitude were modulated by visual and prior information reliability...
May 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29904149/stress-peptides-sensitize-fear-circuitry-to-promote-passive-coping
#10
Pinelopi Pliota, Vincent Böhm, Florian Grössl, Johannes Griessner, Ornella Valenti, Klaus Kraitsy, Joanna Kaczanowska, Manuel Pasieka, Thomas Lendl, Jan M Deussing, Wulf Haubensak
Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances in dissecting mammalian circuitry for Pavlovian fear, the neuronal basis underlying this form of non-Pavlovian anxiety-related behavioral plasticity remains poorly understood. Here, we report that aversive experience recruits the posterior paraventricular thalamus (PVT) and corticotropin-releasing hormone (CRH) and sensitizes a Pavlovian fear circuit to promote passive responding...
June 14, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29903996/applications-of-nanomaterials-based-on-magnetite-and-mesoporous-silica-on-the-selective-detection-of-zinc-ion-in-live-cell-imaging
#11
Roghayeh Sadeghi Erami, Karina Ovejero, Soraia Meghdadi, Marco Filice, Mehdi Amirnasr, Antonio Rodríguez-Diéguez, María Ulagares De La Orden, Santiago Gómez-Ruiz
Functionalized magnetite nanoparticles (FMNPs) and functionalized mesoporous silica nanoparticles (FMSNs) were synthesized by the conjugation of magnetite and mesoporous silica with the small and fluorogenic benzothiazole ligand, that is, 2(2-hydroxyphenyl)benzothiazole ( hpbtz ). The synthesized fluorescent nanoparticles were characterized by FTIR, XRD, XRF, 13 C CP MAS NMR, BET, and TEM. The photophysical behavior of FMNPs and FMSNs in ethanol was studied using fluorescence spectroscopy. The modification of magnetite and silica scaffolds with the highly fluorescent benzothiazole ligand enabled the nanoparticles to be used as selective and sensitive optical probes for zinc ion detection...
June 14, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29903970/neural-scene-representation-and-rendering
#12
S M Ali Eslami, Danilo Jimenez Rezende, Frederic Besse, Fabio Viola, Ari S Morcos, Marta Garnelo, Avraham Ruderman, Andrei A Rusu, Ivo Danihelka, Karol Gregor, David P Reichert, Lars Buesing, Theophane Weber, Oriol Vinyals, Dan Rosenbaum, Neil Rabinowitz, Helen King, Chloe Hillier, Matt Botvinick, Daan Wierstra, Koray Kavukcuoglu, Demis Hassabis
Scene representation-the process of converting visual sensory data into concise descriptions-is a requirement for intelligent behavior. Recent work has shown that neural networks excel at this task when provided with large, labeled datasets. However, removing the reliance on human labeling remains an important open problem. To this end, we introduce the Generative Query Network (GQN), a framework within which machines learn to represent scenes using only their own sensors. The GQN takes as input images of a scene taken from different viewpoints, constructs an internal representation, and uses this representation to predict the appearance of that scene from previously unobserved viewpoints...
June 15, 2018: Science
https://www.readbyqxmd.com/read/29903902/payments-for-environmental-services-supported-social-capital-while-increasing-land-management
#13
Jennifer M Alix-Garcia, Katharine R E Sims, Victor H Orozco-Olvera, Laura E Costica, Jorge David Fernández Medina, Sofía Romo Monroy
Payments for environmental services (PES) programs incentivize landowners to protect or improve natural resources. Many conservationists fear that introducing compensation for actions previously offered voluntarily will reduce social capital (the institutions, relationships, attitudes, and values that govern human interactions), yet little rigorous research has investigated this concern. We examined the land cover management and communal social capital impacts of Mexico's federal conservation payments program, which is a key example for other countries committed to reducing deforestation, protecting watersheds, and conserving biodiversity...
June 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29903615/neurotransmitter-modulation-by-the-gut-microbiota
#14
Philip Strandwitz
The gut microbiota - the trillions of bacteria that reside within the gastrointestinal tract - has been found to not only be an essential component immune and metabolic health, but also seems to influence development and diseases of the enteric and central nervous system, including motility disorders, behavioral disorders, neurodegenerative disease, cerebrovascular accidents, and neuroimmune-mediated disorders. By leveraging animal models, several different pathways of communication have been identified along the "gut-brain-axis" including those driven by the immune system, the vagus nerve, or by modulation of neuroactive compounds by the microbiota...
August 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29903544/the-impact-of-traumatic-experiences-on-risky-sexual-behaviors-in-black-and-white-young-adult-women
#15
Kimberly B Werner, Renee M Cunningham-Williams, Whitney Sewell, Arpana Agrawal, Vivia V McCutcheon, Mary Waldron, Andrew C Heath, Kathleen K Bucholz
BACKGROUND: Trauma exposure has been linked to risky sexual behavior (RSB), but few studies have examined the impact of distinct trauma types on RSB in one model or how the association with trauma and RSB may differ across race. PURPOSE: The objective of the current study was to examine the contribution of trauma exposure types to RSB-substance-related RSB and partner-related RSB identified through factor analysis-in young Black and White adult women. METHODS: We investigated the associations of multiple trauma types and RSB factor scores in participants from a general population sample of young adult female twins (n = 2,948)...
June 11, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29903532/muscleless-motor-synergies-and-actions-without-movements-from-motor-neuroscience-to-cognitive-robotics
#16
REVIEW
Vishwanathan Mohan, Ajaz Bhat, Pietro Morasso
Emerging trends in neurosciences are providing converging evidence that cortical networks in predominantly motor areas are activated in several contexts related to 'action' that do not cause any overt movement. Indeed for any complex body, human or embodied robot inhabiting unstructured environments, the dual processes of shaping motor output during action execution and providing the self with information related to feasibility, consequence and understanding of potential actions (of oneself/others) must seamlessly alternate during goal-oriented behaviors, social interactions...
April 27, 2018: Physics of Life Reviews
https://www.readbyqxmd.com/read/29903452/functional-topography-of-the-human-cerebellum
#17
Catherine J Stoodley, Jeremy D Schmahmann
Accumulating evidence points to a critical role for the human cerebellum in both motor and nonmotor behaviors. A core tenet of this new understanding of cerebellar function is the existence of functional subregions within the cerebellum that differentially support motor, cognitive, and affective behaviors. This cerebellar functional topography - based on converging evidence from neuroanatomic, neuroimaging, and clinical studies - is evident in both adult and pediatric populations. The sensorimotor homunculi in the anterior lobe and lobule VIII established in early tract tracing and electrophysiologic studies are evident in both task-based and resting-state human functional imaging studies...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29903438/cognitive-aspects-sequencing-behavior-and-executive-functions
#18
Marco Molinari, Marcella Masciullo, Sara Bulgheroni, Stefano D'Arrigo, Daria Riva
The question posed today is not whether the cerebellum plays a role in cognition, but instead, how the cerebellum contributes to cognitive processes, even in the developmental age. The central role of the cerebellum in many areas of human abilities, motor as well as cognitive, in childhood as well as in adulthood, is well established but cerebellar basic functioning is still not clear and is much debated. Of particular interest is the changing face of cerebellar influence on motor, higher cognitive, and behavioral functioning when adult and developmental lesions are compared...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29902616/billings-reservoir-water-used-for-human-consumption-presents-microbiological-contaminants-and-induces-both-behavior-impairments-and-astrogliosis-in-zebrafish
#19
Ednilse Leme, Ericka P Silva, Paula S Rodrigues, Igor R Silva, Maria F M Martins, Eduardo F Bondan, Maria M Bernardi, Thiago B Kirsten
The Billings reservoir is the largest water-storage facility in the São Paulo Metropolitan Region, with only a small part of the reservoir used for water supply. Recently, the São Paulo Metropolitan Region has experienced the greatest water collapse ever recorded. Thus, the intensification of use of the Billings reservoir should be considered. The objective of this study was to evaluate the quality of the water from different areas of the Billings reservoir related to human consumption (water supply and fishing): Rio Pequeno, Rio Grande, and Bororé rivers...
June 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29902284/environmental-impact-of-switching-from-the-synthetic-glucocorticoid-prednisolone-to-the-natural-alkaloid-berberine
#20
Iris E Allijn, Rik Oldenkamp, Gert Storm, Ad M J Ragas, Raymond M Schiffelers
Low amounts of human pharmaceuticals in the aquatic environment can affect bacteria, animals and ultimately humans. Here, the environmental consequences of a shift in prescription behavior from prednisolone to berberine was modeled using an environmental decision support system based on four consecutive steps: emission, fate, exposure and effect. This model estimates the relative aquatic and human health impacts of alternative pharmaceutical prescriptions throughout Europe. Since a Defined Daily Dose (DDD) of berberine has yet to be formulated, the environmental impacts of berberine and prednisolone were compared under the assumption of equal DDDs...
2018: PloS One
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