keyword
MENU ▼
Read by QxMD icon Read
search

Human behavior

keyword
https://www.readbyqxmd.com/read/29222842/kinetic-characterisation-of-wild-type-and-mutant-human-thioredoxin-glutathione-reductase-defines-its-reaction-and-regulatory-mechanisms
#1
Christina Brandstaedter, Karin Fritz-Wolf, Stine Weder, Marina Fischer, Beate Hecker, Stefan Rahlfs, Katja Becker
In most cells the thioredoxin (Trx) and glutathione systems are essentially involved in maintaining redox homeostasis. The selenoprotein thioredoxin glutathione reductase (TGR) is a hybrid enzyme in which a glutaredoxin (Grx) domain is linked to a thioredoxin reductase (TrxR). Notably, the protein is also capable of reducing glutathione disulfide (GSSG) thus representing an important link between the two redox systems. In this study, we recombinantly produced human TGR (hTGR wild type) by fusing its open reading frame with a bacterial SECIS element and co-expressing the construct in E...
December 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29222801/culture-of-human-primary-bone-cells-and-phenotype-assessment
#2
Paola Brun
Bone engineering scaffolds and biomimetic substitutes are currently the leading techniques to repair and regenerate bone defects. Ideally, bone grafts should imitate the structure and properties of bone extracellular matrix, house osteoprogenitor cells, and provide all the necessary environmental cues to orchestrate the functions of osteoblast and osteoclast cells. Consequently, there is an increasing demand for preclinical models based on in vitro bone-derived cell cultures for screening of novel biomaterials...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222770/ocular-nerve-growth-factor-ngf-and-ngf-eye-drop-application-as-paradigms-to-investigate-ngf-neuroprotective-and-reparative-actions
#3
Paola Tirassa, Pamela Rosso, Angela Iannitelli
The eye is a central nervous system structure that is uniquely accessible to local treatment. Through the ocular surface, it is possible to access the retina, optic nerve, and brain. Animal models of retina degeneration or optic nerve crush could thus serve as tools to investigate whether and how factors, which are anterogradely or retrogradely transported through the optic nerve, might contribute to activate neuroprotection and eventually regeneration. Among these factors, nerve growth factor (NGF) plays a crucial role during development of the visual system, as well as during the entire life span, and in pathological conditions...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222403/common-pathophysiology-in-multiple-mouse-models-of-pitt-hopkins-syndrome
#4
Courtney Thaxton, Alexander D Kloth, Ellen P Clark, Sheryl S Moy, Raymond A Chitwood, Benjamin D Philpot
Mutations or deletions of the transcription factor TCF4 are linked to Pitt-Hopkins syndrome (PTHS) and schizophrenia, suggesting that the precise pathogenic mutations dictate cellular, synaptic, and behavioral consequences. Here we generated two novel mouse models of PTHS-one that mimics the most common pathogenic TCF4 point mutation (human R580W, mouse R579W) and one that deletes three pathogenic arginines-and explored phenotypes of these lines alongside models of pan-cellular or CNS-specific heterozygous Tcf4 disruption...
December 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29222081/media-consumption-and-creation-in-attitudes-toward-and-knowledge-of-inflammatory-bowel-disease-web-based-survey
#5
Jacob Groshek, Miles Basil, Ling Guo, Sarah Parker Ward, Francis A Farraye, Jason Reich
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition affecting over 5 million people globally and 1.6 million in the United States but currently lacks a precisely determined cause or cure. The range of symptoms IBD patients experience are often debilitating, and the societal stigmas associated with some such symptoms can further degrade their quality of life. Better understanding the nature of this public reproach then is a critical component for improving awareness campaigns and, ultimately, the experiences of IBD patients...
December 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29222069/cooperativity-between-different-trna-modifications-and-their-modification-pathways
#6
REVIEW
Mikołaj Sokołowski, Roland Klassen, Alexander Bruch, Raffael Schaffrath, Sebastian Glatt
Ribonucleotide modifications perform a wide variety of roles in synthesis, turnover and functionality of tRNA molecules. The presence of particular chemical moieties can refine the internal interaction network within a tRNA molecule, influence its thermodynamic stability, contribute novel chemical properties and affect its decoding behavior during mRNA translation. As the lack of specific modifications in the anticodon stem and loop causes disrupted proteome homeostasis, diminished response to stress conditions, and the onset of human diseases, the underlying modification cascades have recently gained particular scientific and clinical interest...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29222015/synthesis-and-evaluation-on-ph-and-temperature-responsive-chitosan-p-maa-co-nipam-hydrogels
#7
S Z M Rasib, Z Ahmad, A Khan, H M Akil, M B H Othman, Z A A Hamid, F Ullah
In this study, chitosan-poly(methacrylic acid-co-N-isopropylacrylamide) [chitosan-p(MAA-co-NIPAM)] hydrogels were synthesized by emulsion polymerization. In order to be used as a carrier for drug delivery systems, the hydrogels had to be biocompatible, biodegradable and multi-responsive. The polymerization was performed by copolymerize MAA and NIPAM with chitosan polymer to produce a chitosan-based hydrogel. Due to instability during synthesis and complexity of components to produce the hydrogel, further study at different times of reaction is important to observe the synthesis process, the effect of end product on swelling behavior and the most important is to find the best way to control the hydrogel synthesis in order to have an optimal swelling behavior for drug release application...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221472/odontoblast-like-differentiation-and-mineral-formation-of-pulpsphere-derived-cells-on-human-root-canal-dentin-in-vitro
#8
Jörg Neunzehn, Sandra Pötschke, Christian Hannig, Hans-Peter Wiesmann, Marie-Theres Weber
BACKGROUND: The revitalization or regeneration of the dental pulp is a preferable goal in current endodontic research. In this study, human dental pulp cell (DPC) spheres were applied to human root canal samples to evaluate their potential adoption for physiological tissue-like regeneration of the dental root canal by odontoblastic differentiation as well as cell-induced mineral formation. METHODS: DPC were cultivated into three-dimensional cell spheres and seeded on human root canal specimens...
December 8, 2017: Head & Face Medicine
https://www.readbyqxmd.com/read/29221164/inhibition-of-x-linked-inhibitor-of-apoptosis-protein-suppresses-tumorigenesis-and-enhances-chemosensitivity-in-anaplastic-thyroid-carcinoma
#9
Yao Liu, Bing Zhang, Tiefeng Shi, Huadong Qin
Anaplastic thyroid carcinoma (ATC) is one of the most lethal carcinoma with a poor prognosis; however, molecular mechanisms underlying the aggressiveness of ATC remain unclear. Our goal was to examine the expression of X-linked inhibitor of apoptosis protein (XIAP) in ATC, as well as its role in ATC tumorigenesis. This is a retrospective study of ATC patients from the Second Affiliated Hospital of Harbin Medical University during June 2003 to October 2013. The expression of XIAP in tumor specimens of ATC patients was examined by immunohistochemical staining...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221126/the-clinicopathological-and-prognostic-significances-of-cdc73-expression-in-cancers-a-bioinformatics-analysis
#10
Hua-Chuan Zheng, Bao-Cheng Gong, Shuang Zhao
CDC73 interacts with human PAF1 complex, histone methyltransferase complex and RNA polymerase II for transcription elongation and 3' end processing. Its down-regulated expression was immunohistochemically detected in gastric, colorectal, ovarian and head and neck cancers, and positively correlated with aggressive behaviors and unfavorable prognosis of malignancies. We performed a bioinformatics analysis by using Oncomine, TCGA and KM plotter databases. It was found that CDC73 mRNA was overexpressed in gastric, lung, breast and ovarian cancers, even stratified by histological subtypes (p<0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220801/assessment-of-temperature-and-ultraviolet-radiation-effects-on-sunburn-incidence-at-an-inland-u-s-beach-a-cohort-study
#11
Jason W Marion, Jiyoung Lee, James S Rosenblum, Timothy J Buckley
BACKGROUND: Increases in outdoor temperature may lead to increases in sunburn, outdoor exposure, and skin cancer in human populations. OBJECTIVE: This study aimed to quantify sunburn incidence and risk for Ohio beachgoers exposed to varying outdoor conditions. METHODS: Sunburn incidence data were obtained through a prospective cohort study at East Fork Lake (Cincinnati, Ohio, USA). Recruitment occurred over 26 weekend days. Beach interviews and follow-up telephone interviews obtained exposure and health information...
December 5, 2017: Environmental Research
https://www.readbyqxmd.com/read/29220570/neuromicrobiology-how-microbes-influence-the-brain
#12
Cesar de la Fuente-Nunez, Beatriz Torres Meneguetti, Octávio Luiz Franco, Timothy K Lu
We review here recent discoveries in the exciting new field of neuromicrobiology. This field encompasses the interactions between the microbiome and the central nervous system. The microbiome has a tremendous impact on human health. In particular, the gut microbiota may play a key role in many essential processes in health and disease via the activity of the gut-brain axis, possibly contributing to autism spectrum disorders, Alzheimer's disease, Parkinson's disease, depression, and anxiety disorder. Gut microbes may also be involved in nociception, complex host behaviors, and brain development...
December 8, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29218741/a-test-of-the-substitution-habitat-hypothesis-in-amphibians
#13
Alejandro Martínez-Abraín, Pedro Galán
Most examples that support the substitution-habitat hypothesis (human-made habitats act as substitutes of original habitat) deal with birds and mammals. We tested this hypothesis in 14 amphibians by using percentage occupancy as a proxy of habitat quality (i.e., higher occupancy percentages indicate higher quality). We classified water body types as original habitat (no or little human influence) depending on anatomical, behavioral, or physiological adaptations of each amphibian species. Ten species had relatively high probabilities (0...
December 8, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29218631/intracellular-metal-binding-and-redox-behavior-of-human-dj-1
#14
Letizia Barbieri, Enrico Luchinat, Lucia Banci
DJ-1 is a conserved, ubiquitous protein associated to a large number of intracellular processes. Human DJ-1 has been linked to several pathologies, including hereditary forms of Parkinson's disease, cancer, and amyotrophic lateral sclerosis. Several cytoprotective functions of DJ-1 have been reported, however, its actual mechanisms of action remain elusive. In vitro, DJ-1 has been shown to bind zinc and copper(II) at its active site, which contains a conserved cysteine (C106), and copper(I) at a different binding site...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29218323/sap97-binding-partner-cript-promotes-dendrite-growth-in-vitro-and-in-vivo
#15
Lei Zhang, Angela Marie Jablonski, Jelena Mojsilovic-Petrovic, Hua Ding, Steven Seeholzer, Ian Paterson Newton, Inke Nathke, Rachael Neve, JinBin Zhai, Yuan Shang, Mingjie Zhang, Robert Gordon Kalb
The dendritic tree is a key determinant of neuronal information processing. In the motor system, the dendritic tree of spinal cord neurons undergoes dramatic remodeling in an activity-dependent manner during early postnatal life. This leads to the proper segmental spinal cord connectivity that subserves normal locomotor behavior. One molecular system driving the establishment of dendrite architecture of mammalian motor neurons relies on AMPA receptors (AMPA-Rs) assembled with the GluA1 subunit, and this occurs in an NMDA receptor (NMDA-R)-independent manner...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29218308/opportunities-for-crispr-cas9-gene-editing-in-retinal-regeneration-research
#16
REVIEW
Leah J Campbell, David R Hyde
While retinal degeneration and disease results in permanent damage and vision loss in humans, the severely damaged zebrafish retina has a high capacity to regenerate lost neurons and restore visual behaviors. Advancements in understanding the molecular and cellular basis of this regeneration response give hope that strategies and therapeutics may be developed to restore sight to blind and visually-impaired individuals. Our current understanding has been facilitated by the amenability of zebrafish to molecular tools, imaging techniques, and forward and reverse genetic approaches...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29218022/association-between-unintentional-interpersonal-postural-coordination-produced-by-interpersonal-light-touch-and-the-intensity-of-social-relationship
#17
Tomoya Ishigaki, Ryota Imai, Shu Morioka
Interpersonal postural coordination (IPC) produced by interpersonal light touch (ILT), whereby time-series variations in the postural sway between two people unintentionally resemble each other, may be a possible social interaction. From a sociopsychological standpoint, close mutual behavioral coordination is recognized as "social glue," which represents the closeness of relationships and contributes to the building of a good rapport. Therefore, we hypothesized that if IPC functions as social glue, then IPC produced by ILT also represents a social relationship...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29218005/distributed-neural-activity-patterns-during-human-to-human-competition
#18
Matthew Piva, Xian Zhang, J Adam Noah, Steve W C Chang, Joy Hirsch
Interpersonal interaction is the essence of human social behavior. However, conventional neuroimaging techniques have tended to focus on social cognition in single individuals rather than on dyads or groups. As a result, relatively little is understood about the neural events that underlie face-to-face interaction. We resolved some of the technical obstacles inherent in studying interaction using a novel imaging modality and aimed to identify neural mechanisms engaged both within and across brains in an ecologically valid instance of interpersonal competition...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29217997/neurochemical-and-behavior-deficits-in-rats-with-iron-and-rotenone-co-treatment-role-of-redox-imbalance-and-neuroprotection-by-biochanin-a
#19
Lijia Yu, Xijin Wang, Hanqing Chen, Zhiqiang Yan, Meihua Wang, Yunhong Li
Increasing evidences show that the etiology of Parkinson's disease (PD) is multifactorial. Studying the combined effect of several factors is becoming a hot topic in PD research. On one hand, iron is one of the essential trace metals for human body; on the other hand, iron may be involved in the etiopathogenesis of PD. In our present study, the rats with increased neonatal iron (120 μg/g bodyweight) supplementation were treated with rotenone (0.5 mg/kg) when they were aged to 14 weeks. We observed that iron and rotenone co-treatment induced significant behavior deficits (time-dependent) and striatal dopamine depletion in the male and female rats, while they did not do so when they were used alone...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29217994/local-fields-in-human-subthalamic-nucleus-track-the-lead-up-to-impulsive-choices
#20
John M Pearson, Patrick T Hickey, Shivanand P Lad, Michael L Platt, Dennis A Turner
The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the basis of studies demonstrating a link between beta-band synchronization and severity of motor symptoms in PD, the minimization of beta band activity has been proposed as a potential training target for closed-loop DBS. At present, no comparable signal is known for the impulsive side effects of PD, though multiple studies have implicated theta band activity within the subthalamic nucleus (STN), the site of DBS treatment, in processes of conflict monitoring and countermanding...
2017: Frontiers in Neuroscience
keyword
keyword
18481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"