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https://www.readbyqxmd.com/read/28551686/human-rad52-interactions-with-replication-protein-a-and-the-rad51-presynaptic-complex
#1
Chu Jian Ma, YoungHo Kwon, Patrick Sung, Eric C Greene
Rad52 is a highly-conserved protein involved in the repair of DNA damage. Human RAD52 has been shown to mediate ssDNA annealing and is synthetic lethal with mutations in other key recombination proteins. Here, we use single-molecule imaging and ssDNA curtains to examine the binding interactions of human RAD52 with RPA-coated ssDNA, and we monitor the fate of RAD52 during assembly of the presynaptic complex. We show that RAD52 binds tightly to the RPA-ssDNA complex and imparts an inhibitory effect on RPA turnover...
May 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28551585/lethal-and-sub-lethal-evaluation-of-indigo-carmine-dye-and-byproducts-after-tio2-photocatalysis-in-the-immune-system-of-eisenia-andrei-earthworms
#2
Patrícia Christina Genázio Pereira, Roberta Valoura Reimão, Thelma Pavesi, Enrico Mendes Saggioro, Josino Costa Moreira, Fábio Veríssimo Correia
The Indigo carmine (IC) dye has been widely used in textile industries, even though it has been considered toxic for rats, pigs and humans. Owing to its toxicity, wastes containing this compound should be treated to minimize or eliminate their toxic effects on the biota. As an alternative to wastewater treatment, advanced oxidative processes (AOPs) have been highlighted due to their high capacity to destruct organic molecules. In this context, this study aimed to evaluate Indigo Carmine toxicity to soil organisms using the earthworm Eisenia andrei as a model-organism and also verify the efficiency of AOP in reducing its toxicity to these organisms...
May 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28551363/salamanders-on-the-bench-a-biocompatibility-study-of-salamander-skin-secretions-in-cell-cultures
#3
Janek von Byern, Dietrich Mebs, Egon Heiss, Ursula Dicke, Oliver Wetjen, Kristin Bakkegard, Ingo Grunwald, Susanne Wolbank, Severin Mühleder, Alfred Gugerell, Heidemarie Fuchs, Sylvia Nuernberger
Salamanders have evolved a wide variety of antipredator mechanisms and behavior patterns, including toxins and noxious or adhesive skin secretions. The high bonding strength of the natural bioadhesives makes these substances interesting for biomimetic research and applications in industrial and medical sectors. Secretions of toxic species may help to understand the direct effect of harmful substances on the cellular level. In the present study, the biocompatibility of adhesive secretions from four salamander species (Plethodon shermani, Plethodon glutinosus, Ambystoma maculatum, Ambystoma opacum) were analyzed using the MTT assay in cell culture and evaluated against toxic secretions of Pleurodeles waltl, Triturus carnifex, Pseudotriton ruber, Tylototriton verrucosus, and Salamandra salamandra...
May 24, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28551190/clinical-trial-of-local-anesthetic-protocols-for-acute-pain-associated-with-caustic-paste-disbudding-in-dairy-calves
#4
Charlotte B Winder, Stephen J LeBlanc, Derek B Haley, Kerry D Lissemore, M Ann Godkin, Todd F Duffield
Caustic paste disbudding is becoming more commonplace in North America. A large body of work has examined pain control for cautery disbudding and surgical dehorning, but fewer studies have evaluated pain control for caustic paste disbudding, and results conflict regarding benefits of local anesthesia. In humans, the pain associated with a caustic, chemical burn can differ in nature, duration, and intensity compared with a thermal burn. The objective of this clinical trial was to evaluate the effects of either a lidocaine cornual nerve block or a topical anesthetic incorporated into caustic paste on the acute pain of caustic paste disbudding...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551067/the-neural-correlates-of-reciprocity-are-sensitive-to-prior-experience-of-reciprocity
#5
Ricardo Cáceda, Stefania Prendes-Alvarez, Jung-Jiin Hsu, Shanti P Tripathi, Clint D Kilts, G Andrew James
Reciprocity is central to human relationships and is strongly influenced by multiple factors including the nature of social exchanges and their attendant emotional reactions. Despite recent advances in the field, the neural processes involved in this modulation of reciprocal behavior by ongoing social interaction are poorly understood. We hypothesized that activity within a discrete set of neural networks including a putative moral cognitive neural network is associated with reciprocity behavior. Nineteen healthy adults underwent functional magnetic resonance imaging scanning while playing the trustee role in the Trust Game...
May 24, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28550727/multiple-remote-sensing-data-sources-to-assess-spatio-temporal-patterns-of-fire-incidence-over-campos-amaz%C3%A3-nicos-savanna-vegetation-enclave-brazilian-amazon
#6
Daniel Borini Alves, Fernando Pérez-Cabello
Fire activity plays an important role in the past, present and future of Earth system behavior. Monitoring and assessing spatial and temporal fire dynamics have a fundamental relevance in the understanding of ecological processes and the human impacts on different landscapes and multiple spatial scales. This work analyzes the spatio-temporal distribution of burned areas in one of the biggest savanna vegetation enclaves in the southern Brazilian Amazon, from 2000 to 2016, deriving information from multiple remote sensing data sources (Landsat and MODIS surface reflectance, TRMM pluviometry and Vegetation Continuous Field tree cover layers)...
May 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28550604/microencapsulation-of-%C3%AE-carotene-based-on-casein-guar-gum-blend-using-zeta-potential-yield-stress-phenomenon-an-approach-to-enhance-photo-stability-and-retention-of-functionality
#7
Deepika Thakur, Ashay Jain, Gargi Ghoshal, U S Shivhare, O P Katare
β-Carotene, abundant majorly in carrot, pink guava yams, spinach, kale, sweet potato, and palm oil, is an important nutrient for human health due to its scavenging action upon reactive free radicals wherever produced in the body. Inclusion of liposoluble β-carotene in foods and food ingredients is a challenging aspect due to its labile nature and low absorption from natural sources. This fact has led to the application of encapsulation of β-carotene to improve stability and bioavailability. The present work was aimed to fabricate microcapsules (MCs) of β-carotene oily dispersion using the complex coacervation technique with casein (CA) and guar gum (GG) blend...
May 26, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28550267/amyloid-precursor-protein-haploinsufficiency-preferentially-mediates-brain-iron-accumulation-in-mice-transgenic-for-the-huntington-s-disease-mutation
#8
Kiersten Berggren, Sonal Agrawal, Julia A Fox, Justin Hildenbrand, Ryan Nelson, Ashley I Bush, Jonathan H Fox
BACKGROUND: Huntington's disease (HD) is an autosomal dominant disorder caused by a CAG expansion in the huntingtin gene that results in expression of mutant huntingtin protein. Iron accumulates in HD brain neurons. Amyloid precursor protein (APP) promotes neuronal iron export. However, the role of APP in brain iron accumulation in HD is unclear. OBJECTIVE: To determine the effects of APP insufficiency on HD in YAC128 mice. METHODS: We crossed APP hemizygous mice (APP+/-) with YAC128 mice that are transgenic (Tg) for human mutant huntingtin (hmHTT) to generate APP+/+ hmHTT-/-, APP+/- hmHTT-/-, APP+/+ hmHTT+/- and APP+/- hmHTT+/- progeny...
May 24, 2017: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/28550016/genomic-analysis-of-genotype-by-social-environment-interaction-for-drosophila-aggressive-behavior
#9
Palle Duun Rohde, Bryn Gaertner, Kirsty Wards, Peter Sørensen, Trudy F C Mackay
Human psychiatric disorders such as schizophrenia, bipolar disorder and attention-deficit/hyper-activity disorder often include adverse behaviors including increased aggressiveness. Individuals with psychiatric disorders often exhibit social withdrawal, which can further increase the probability of conducting a violent act. Here, we used the inbred, sequenced lines of the Drosophila Genetic Reference Panel (DGRP) to investigate the genetic basis of variation in male aggressive behavior for flies reared in a socialized and socially isolated environment...
May 26, 2017: Genetics
https://www.readbyqxmd.com/read/28549649/prolonged-deficits-of-associative-motor-learning-in-cynomolgus-monkeys-after-long-term-administration-of-phencyclidine
#10
Bing Wu, Xu-Dong Zhao, Hui-Min Zhang, Xuan Li, Guang-Yan Wu, Ying-Shan Yang, Chao-Yang Tian, Jian-Feng Sui
Phencyclidine (PCP) is a potent drug of abuse that induces sustained schizophrenia-like symptoms in humans by blocking neurotransmission at N-methyl-D-aspartate (NMDA)-type glutamate receptors. Alterations in NMDA receptor function have been linked to numerous behavioral deficits and cognitive dysfunction. Classical eye-blink conditioning (EBC), including delay (dEBC) and trace (tEBC) pafadigms, provides an effective means to study the neurobiology of associative motor learning in rodents, mammals and primates...
May 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28549648/characterization-of-long-term-gait-deficits-in-mouse-dmcao-using-the-catwalk-system
#11
E Caballero-Garrido, J C Pena-Philippides, Z Galochkina, E Erhardt, T Roitbak
Evaluation of functional outcome is widely used across species to assess the recovery process following various pathological conditions, including spinal cord injury, musculo-skeletal injury, mithochondrial disease, neuropathic cancer, Huntington's disease, chronic pain, cortical lesion, and olivocerebellar degeneration among others. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends multiple endpoints for behavioral studies in pre-clinical stroke research, to demonstrate their clinical relevance...
May 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28549270/the-effects-of-early-life-adversity-on-the-immune-system
#12
REVIEW
Martha M C Elwenspoek, Annette Kuehn, Claude P Muller, Jonathan D Turner
Early life adversity (ELA) is associated with a higher risk for diseases in adulthood. Although the pathophysiological effects of ELA are varied, there may be a unifying role for the immune system in all of the long-term pathologies such as chronic inflammatory disorders (autoimmune diseases, allergy, and asthma). Recently, significant efforts have been made to elucidate the long-term effects ELA has on immune function, as well as the mechanisms underlying these immune changes. In this review, we focus on data from human studies investigating immune parameters in relation to post-natal adverse experiences...
May 17, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28548897/evening-light-exposure-to-computer-screens-disrupts-human-sleep-biological-rhythms-and-attention-abilities
#13
A Green, M Cohen-Zion, A Haim, Y Dagan
The use of electronic devices with light-emitting screens has increased exponentially in the last decade. As a result, humans are almost continuously exposed to unintentional artificial light. We explored the independent and combined effects of two aspects of screen illumination, light wavelength, and intensity, on sleep, its biological regulation, and related functional outcomes. The 2 × 2 repeated-measure design included two independent variables: screen light intensity (low ([LI] versus high [HI]) and wavelength (short [SWL] versus long [LWL])...
May 26, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28548460/internally-generated-hippocampal-sequences-as-a-vantage-point-to-probe-future-oriented-cognition
#14
REVIEW
Giovanni Pezzulo, Caleb Kemere, Matthijs A A van der Meer
Information processing in the rodent hippocampus is fundamentally shaped by internally generated sequences (IGSs), expressed during two different network states: theta sequences, which repeat and reset at the ∼8 Hz theta rhythm associated with active behavior, and punctate sharp wave-ripple (SWR) sequences associated with wakeful rest or slow-wave sleep. A potpourri of diverse functional roles has been proposed for these IGSs, resulting in a fragmented conceptual landscape. Here, we advance a unitary view of IGSs, proposing that they reflect an inferential process that samples a policy from the animal's generative model, supported by hippocampus-specific priors...
May 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28548250/evolution-of-deep-gray-matter-volume-across-the-human-lifespan
#15
Karl Narvacan, Sarah Treit, Richard Camicioli, Wayne Martin, Christian Beaulieu
Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross-sectional cohort of 406 subjects aged 5-83 years; (ii) a longitudinal neurodevelopment cohort of 84 subjects scanned twice approximately 4 years apart, aged 5-27 years at first scan; and (iii) a longitudinal aging cohort of 55 subjects scanned twice approximately 3 years apart, aged 46-83 years at first scan...
May 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28547702/emerging-treatments-in-eating-disorders
#16
REVIEW
Michael Lutter
Eating disorders (EDs), including anorexia nervosa, bulimia nervosa, and binge-eating disorder, constitute a class of common and deadly psychiatric disorders. While numerous studies in humans highlight the important role of neurobiological alterations in the development of ED-related behaviors, the precise neural substrate that mediates this risk is unknown. Historically, pharmacological interventions have played a limited role in the treatment of eating disorders, typically providing symptomatic relief of comorbid psychiatric issues, like depression and anxiety, in support of the standard nutritional and psychological treatments...
May 25, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28547032/car8-dorsal-root-ganglion-expression-and-genetic-regulation-of-analgesic-responses-are-associated-with-a-cis-eqtl-in-mice
#17
Roy C Levitt, Gerald Y Zhuang, Yuan Kang, Diana M Erasso, Udita Upadhyay, Mehtap Ozdemir, Eugene S Fu, Konstantinos D Sarantopoulos, Shad B Smith, William Maixner, Luda Diatchenko, Eden R Martin, Tim Wiltshire
Carbonic anhydrase-8 (Car8 mouse gene symbol) is devoid of enzymatic activity, but instead functions as an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1) to regulate this intracellular calcium release channel important in synaptic functions and neuronal excitability. Causative mutations in ITPR1 and carbonic anhydrase-8 in mice and humans are associated with certain subtypes of spinal cerebellar ataxia (SCA). SCA mice are genetically deficient in dorsal root ganglia (DRG) Car8 expression and display mechanical and thermal hypersensitivity and susceptibility to subacute and chronic inflammatory pain behaviors...
May 25, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28546652/chimpanzees-pan-troglodytes-flexibly-use-introduced-species-for-nesting-and-bark-feeding-in-a-human-dominated-habitat
#18
Maureen S McCarthy, Jack D Lester, Craig B Stanford
As habitat loss and fragmentation place growing pressure on endangered nonhuman primate populations, researchers find increasing evidence for novel responses in behavior. In western Uganda between the Budongo and Bugoma Forests, chimpanzees (Pan troglodytes schweinfurthii) inhabit a mosaic landscape comprising forest fragments, human settlements, and agricultural land. We recorded nests and feeding evidence of unhabituated chimpanzees in this region over a 12-mo period. We found extensive evidence of nesting in introduced tree species, including eucalyptus (Eucalyptus grandis), guava (Psidium guajava), cocoa (Theobroma cacao), and Caribbean pine (Pinus caribaea)...
2017: International Journal of Primatology
https://www.readbyqxmd.com/read/28546651/activity-and-habitat-use-of-chimpanzees-pan-troglodytes-verus-in-the-anthropogenic-landscape-of-bossou-guinea-west-africa
#19
Nicola Bryson-Morrison, Joseph Tzanopoulos, Tetsuro Matsuzawa, Tatyana Humle
Many primate populations inhabit anthropogenic landscapes. Understanding their long-term ability to persist in such environments and associated real and perceived risks for both primates and people is essential for effective conservation planning. Primates in forest-agricultural mosaics often consume cultivars to supplement their diet, leading to potentially negative encounters with farmers. When crossing roads, primates also face the risk of encounters with people and collision with vehicles. Chimpanzees (Pan troglodytes verus) in Bossou, Guinea, West Africa, face such risks regularly...
2017: International Journal of Primatology
https://www.readbyqxmd.com/read/28546650/samango-monkeys-cercopithecus-albogularis-labiatus-manage-risk-in-a-highly-seasonal-human-modified-landscape-in-amathole-mountains-south-africa
#20
Katarzyna Nowak, Kirsten Wimberger, Shane A Richards, Russell A Hill, Aliza le Roux
Wild species use habitats that vary in risk across space and time. This risk can derive from natural predators and also from direct and indirect human pressures. A starving forager will often take risks that a less hungry forager would not. At a highly seasonal and human-modified site, we predicted that arboreal samango monkeys (Cercopithecus albogularis labiatus) would show highly flexible, responsive, risk-sensitive foraging. We first determined how monkeys use horizontal and vertical space across seasons to evaluate if high-risk decisions (use of gardens and ground) changed with season, a proxy for starvation risk...
2017: International Journal of Primatology
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