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https://www.readbyqxmd.com/read/29352310/leishmania-proteophosphoglycans-regurgitated-from-infected-sand-flies-accelerate-dermal-wound-repair-and-exacerbate-leishmaniasis-via-insulin-like-growth-factor-1-dependent-signalling
#1
Emilie Giraud, Tereza Lěstinová, Tamsyn Derrick, Oihane Martin, Rod J Dillon, Petr Volf, Ingrid Műller, Paul A Bates, Matthew E Rogers
Leishmania parasites are transmitted to vertebrate hosts by female phlebotomine sand flies as they bloodfeed by lacerating the upper capillaries of the dermis with their barbed mouthparts. In the sand fly midgut secreted proteophosphoglycans from Leishmania form a biological plug known as the promastigote secretory gel (PSG), which blocks the gut and facilitates the regurgitation of infective parasites. The interaction between the wound created by the sand fly bite and PSG is not known. Here we nanoinjected a sand fly egested dose of PSG into BALB/c mouse skin that lead to the differential expression of 7,907 transcripts...
January 19, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29343424/igf1-mapk-erk-signaling-pathway-mediated-programming-alterations-of-adrenal-cortex-cell-proliferation-by-prenatal-caffeine-exposure-in-male-offspring-rats
#2
Guanghui Chen, Chao Yuan, Fangfang Duan, Yanyan Liu, Jinzhi Zhang, Zheng He, Hegui Huang, Chunjiang He, Hui Wang
Our previous study proposed a glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming mechanism for prenatal caffeine exposure (PCE)-induced adrenal developmental dysfunction. Here, we focused on PCE-induced cell proliferation changes of the adrenal cortex in male offspring rats before and after birth and clarified the intrauterine programming mechanism. On gestational day (GD) 20, the PCE group had an elevated serum corticosterone level reduced fetal bodyweight, maximum adrenal sectional area, and elevated adrenal corticosterone and aldosterone contents...
January 14, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29340879/diethylstilbestrol-arrested-spermatogenesis-and-somatic-growth-in-the-juveniles-of-yellow-catfish-pelteobagrus-fulvidraco-a-fish-with-sexual-dimorphic-growth
#3
Zhi-Hao Liu, Qi-Liang Chen, Qiang Chen, Fang Li, Ying-Wen Li
In fish, spermatogenesis and somatic growth are mainly regulated by hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-somatic (HPS) axes, respectively. Xenoestrogens have been reported to impair spermatogenesis in some fishes, and arrest somatic growth in some others, whereas, whether xenoestrogens are capable of disrupting spermatogenesis and somatic growth simultaneously in fish that exhibits sexual dimorphic growth is little known, and the underlying mechanisms remain poorly understood. In this study, male juveniles of yellow catfish (Pelteobagrus fulvidraco), which exhibits a sexual dimorphic growth that favors males, were exposed to diethylstilbestrol (DES) for 28 days...
January 16, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29339473/identification-of-thioredoxin-interacting-protein-txnip-as-a-downstream-target-for-igf1-action
#4
Karthik Nagaraj, Lena Lapkina-Gendler, Rive Sarfstein, David Gurwitz, Metsada Pasmanik-Chor, Zvi Laron, Shoshana Yakar, Haim Werner
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, is the best-characterized entity among the congenital insulin-like growth factor 1 (IGF1) deficiencies. Life-long exposure to minute endogenous IGF1 levels is linked to low stature as well as a number of endocrine and metabolic abnormalities. While elevated IGF1 is correlated with increased cancer incidence, epidemiological studies revealed that patients with LS do not develop tumors. The mechanisms associated with cancer protection in LS are yet to be discovered...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339452/effects-of-colostrum-feeding-method-and-oral-igf1-on-porcine-uterine-development
#5
Ashley F George, Kathleen M Rahman, Dori J Miller, Anne A Wiley, Meredith E Camp, Frank Bartol, Carol A Bagnell
Nursing ensures lactocrine delivery of maternally-derived, milk-borne bioactive factors to offspring, which affects postnatal development of female reproductive tract tissues. Disruption of lactocrine communication for two days from birth (postnatal day = PND 0) by feeding milk replacer in lieu of nursing or consumption of colostrum alters porcine uterine gene expression globally by PND 2 and inhibits uterine gland genesis by PND 14. Here, objectives were to determine effects of: 1) nursing or milk replacer feeding from birth; 2) a single dose of colostrum or milk replacer and method of feeding; and 3) a single feeding of colostrum or milk replacer, with or without oral supplementation of IGF1, administered at birth on aspects of porcine uterine development at 12 h postnatally...
January 16, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29339181/effects-of-age-on-growth-in-atlantic-bluefin-tuna-thunnus-thynnus
#6
Martina Api, Erica Bonfanti, Francesco Lombardo, Paolo Pignalosa, Gary Hardiman, Oliana Carnevali
Atlantic Bluefin Tuna Thunnus thynnus (ABFT) is considered one of the most important socio-economic species but there is a lack of information on the physiological and molecular processes regulating its growth and metabolism. In the present study, we focused on key molecules involved in growth process. The aim of the present study was to associate molecular markers related to growth with canonical procedures like morphological measurements such as curved fork length (CFL) and round weight (RWT). The ABFT specimens (n=41) were organized into three different groups A, B and C according to their age...
January 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29330302/controlled-dimerization-of-insulin-like-growth-factor-1-and-insulin-receptors-reveal-shared-and-distinct-activities-of-holo-and-hybrid-receptors
#7
Jingci Chen, Alison M Nagle, Yu-Fen Wang, David N Boone, Adrian V Lee
Breast cancer development and progression is influenced by insulin-like growth factor 1 (IGF1R) and insulin receptor (InsR) signaling that drive cancer phenotypes such as cell growth, proliferation, and migration. IGF1R and InsR form IGF1R/InsR hybrid receptors (HybR) consisting of one molecule of IGF1R and one molecule of InsR. The specific signaling and functions of HybR are largely unknown as HybR is activated by both IGF1 and insulin, and no cellular system expresses HybR in the absence of holo-IGF1R or holo-InsR...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29328908/metabolic-induction-of-trained-immunity-through-the-mevalonate-pathway
#8
Siroon Bekkering, Rob J W Arts, Boris Novakovic, Ioannis Kourtzelis, Charlotte D C C van der Heijden, Yang Li, Calin D Popa, Rob Ter Horst, Julia van Tuijl, Romana T Netea-Maier, Frank L van de Veerdonk, Triantafyllos Chavakis, Leo A B Joosten, Jos W M van der Meer, Henk Stunnenberg, Niels P Riksen, Mihai G Netea
Innate immune cells can develop long-term memory after stimulation by microbial products during infections or vaccinations. Here, we report that metabolic signals can induce trained immunity. Pharmacological and genetic experiments reveal that activation of the cholesterol synthesis pathway, but not the synthesis of cholesterol itself, is essential for training of myeloid cells. Rather, the metabolite mevalonate is the mediator of training via activation of IGF1-R and mTOR and subsequent histone modifications in inflammatory pathways...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29327642/effects-of-arm-cycling-exercise-in-spinal-muscular-atrophy-type-ii-patients-a-pilot-study
#9
Gamze Bora, Şulenur Subaşı-Yıldız, Ayşe Yeşbek-Kaymaz, Numan Bulut, İpek Alemdaroğlu, Öznur Tunca-Yılmaz, Haluk Topaloğlu, Aynur Ayşe Karaduman, Hayat Erdem-Yurter
Exercise studies in neuromuscular diseases like spinal muscular atrophy (SMA), a devastating disease caused by survival of motor neuron 1 ( SMN1) gene mutations, are drawing attention due to its beneficial effects. In this study, we presented a constructed arm cycling exercise protocol and evaluated the benefits on SMA patients. Five SMA type II patients performed 12 weeks of supervised arm cycling exercise. The physical functions were evaluated together with the SMN2 copy numbers, SMN protein levels, insulin-like growth factor 1(IGF1) and binding protein 3 (IGFBP3) levels...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29322301/effects-of-short-term-dhea-intake-on-hormonal-responses-in-young-recreationally-trained-athletes-modulation-by-gender
#10
Katia Collomp, Corinne Buisson, Nicolas Gravisse, Soraya Belgherbi, Zakaria Labsy, Manh-Cuong Do, Olivier Gagey, Sophie Dufay, Nancy Vibarel-Rebot, Michel Audran
BACKGROUND: Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers...
January 10, 2018: Endocrine
https://www.readbyqxmd.com/read/29321175/upregulation-of-gh-but-not-igf1-in-the-hippocampus-of-the-lactating-dam-after-kainic-acid-injury
#11
Elvira C Arellanes-Licea, Jose Avila-Mendoza, Elizabeth C Ramirez-Martinez, Eugenia Ramos, Nancy Uribe-Gonzalez, Carlos Aramburo, Teresa Morales, Maricela Luna
Lactation embodies a natural model of morphological, neurochemical, and functional brain plasticity. In this reproductive stage, the hippocampus of the female is less sensitive to excitotoxins in contrast to nulliparity. Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are known to be neuroprotective in several experimental models of brain lesion. Here, activation of the GH-IGF1 pituitary-brain axis following kainic acid (7.5 mg/kg ip KA) lesion was studied in lactating and nulliparous rats. Serum concentrations of GH and IGF1 were uncoupled in lactation...
January 10, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29317212/folliculogenic-factors-in-photoregressed-ovaries-differences-in-mrna-expression-in-early-compared-to-late-follicle-development
#12
Alexander K Salomon, Kathleen Leon, Melissa M Campbell, Kelly A Young
The early stages of ovarian folliculogenesis generally progress independent of gonadotropins, whereas later stages require signaling initiated by FSH. In Siberian hamsters, cycles of folliculogenesis are mediated by changes in photoperiod which depress the hypothalamic pituitary gonadal axis. Reduced gonadotropins lead to decreases in mature follicle development and ovulation; however, early stages of folliculogenesis have not been explored in regressed ovaries. We hypothesized that intraovarian factors that contribute predominantly to later stages of folliculogenesis would react to changes in photoperiod, whereas factors contributing to earlier stages would not change...
January 6, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29316351/gestational-triphenyl-phosphate-exposure-in-c57bl-6-mice-perturbs-expression-of-insulin-like-growth-factor-signaling-genes-in-maternal-and-fetal-liver
#13
Nicola A Philbrook, Victoria E Restivo, Christine L Belanger, Louise M Winn
Triphenyl phosphate (TPhP) is an organophosphorus flame retardant and plasticizer that has been added to numerous consumer products in recent years. TPhP is not overtly toxic, however recent studies have suggested that it may have metabolic disrupting effects following developmental exposure. The present study aimed to investigate the developmental and potential metabolic effects of TPhP in a murine model. C57Bl/6 dams were exposed on gestational days (GD) 8, 10, 12, and 14 to 0, 5, 25, or 50 mg/kg TPhP via intraperitoneal injection...
January 8, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29314608/unc-120-srf-independently-controls-muscle-aging-and-lifespan-in-caenorhabditis-elegans
#14
Adeline Mergoud Dit Lamarche, Laurent Molin, Laura Pierson, Marie-Christine Mariol, Jean-Louis Bessereau, Kathrin Gieseler, Florence Solari
Aging is commonly defined as the loss of global homeostasis, which results from progressive alteration of all organs function. This model is currently challenged by recent data showing that interventions that extend lifespan do not always increase the overall fitness of the organism. These data suggest the existence of tissue-specific factors that regulate the pace of aging in a cell-autonomous manner. Here, we investigated aging of Caenorhabditis elegans striated muscles at the subcellular and the physiological level...
January 3, 2018: Aging Cell
https://www.readbyqxmd.com/read/29300910/foxo1-is-required-for-most-of-the-metabolic-and-hormonal-perturbations-produced-by-hepatic-insulin-receptor-deletion-in-male-mice
#15
Alisha V Ling, Mary E Gearing, Ivana Semova, Dong-Ju Shin, Rebecca Clements, Zon W Lai, Sudha B Biddinger
Insulin coordinates the complex response to feeding, affecting numerous metabolic and hormonal pathways. FoxO1 is one of several signaling molecules downstream of insulin; FoxO1 drives gluconeogenesis and is suppressed by insulin. To determine the role of FoxO1 in mediating other actions of insulin, we studied mice with hepatic deletion of the insulin receptor, FoxO1, or both. We found that mice with deletion of the insulin receptor alone showed not only hyperglycemia, but a 40% decrease in hepatic Igf1 and delayed growth during the first two months of life, a 24-fold increase in soluble leptin receptor and a 19-fold increase in plasma leptin levels...
December 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/29298280/complete-objective-response-stable-for-5-years-with-the-di-bella-method-of-multiple-metastatic-carcinoma-of-the-breast
#16
Giuseppe Di Bella, Biagio Colori, Rosilde Toscano
Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. We present a case of a woman with carcinoma of the breast and multiple metastases after right mastectomy, axillary dissection, repeated cycles of chemo and radiotherapy, and estrogen block. Biological method formulated by Prof...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29295822/runx2-overexpression-compromises-bone-quality-in-acromegalic-patients
#17
Maria Teresa Valenti, Monica Mottes, Samuele Cheri, Michela Deiana, Valentina Micheletti, Elisa Cosaro, Maria Vittoria Davì, Giuseppe Francia, Luca Dalle Carbonare
Acromegalic patients, characterized by excessive secretion of GH and IGF-1, show a high fracture risk but Bone Mineral Density is a poor predictor for bone fractures in these patients. The effects of an excess of GH/IGF1 on skeleton as well as on osteogenic progenitors, i.e. mesenchymal stem cells, have not been investigated in these patients. We aimed to elucidate the skeletal conditions of acromegalic patients by means of bone microarchitecture analysis and evaluation of MSCs osteogenic commitment. In particular, we performed histomorphometric analyses and we quantified the expression levels of the osteogenic transcription factor RUNX2 in circulating MSCs...
January 2, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29295479/age-dependence-and-aging-dependence-neuronal-loss-and-lifespan-in-a-c-elegans-model-of-parkinson-s-disease
#18
Javier Apfeld, Walter Fontana
It is often assumed, but not established, that the major neurodegenerative diseases, such as Parkinson's disease, are not just age-dependent (their incidence changes with time) but actually aging-dependent (their incidence is coupled to the process that determines lifespan). To determine a dependence on the aging process requires the joint probability distribution of disease onset and lifespan. For human Parkinson's disease, such a joint distribution is not available, because the disease cuts lifespan short...
December 23, 2017: Biology
https://www.readbyqxmd.com/read/29288977/maternal-nutritional-restriction-during-late-gestation-impairs-development-of-the-reproductive-organs-in-both-male-and-female-lambs
#19
F Hoffman, E Boretto, S Vitale, V Gonzalez, G Vidal, M F Pardo, M F Flores, F Garcia, G Bagnis, O C M Queiroz, M B Rabaglino
Maternal nutritional restrictions during late gestation could lead to fetal hypoglycemia. Glucose levels in the fetal sheep regulate circulating insulin-like growth factor 1 (IGF1) levels, which stimulate cell proliferation and differentiation of reproductive organs after binding to its own receptor or estrogen receptors. The objective of this study was to determine the effects of subnutrition of ewes during the last trimester of gestation on the serum glucose/IGF1 levels and development of reproductive organs in their lambs...
December 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/29282328/circulating-insulin-like-growth-factors-and-alzheimer-disease-a-mendelian-randomization-study
#20
Dylan M Williams, Ida K Karlsson, Nancy L Pedersen, Sara Hägg
OBJECTIVE: To examine whether genetically predicted variation in circulating insulin-like growth factor 1 (IGF1) or its binding protein, IGFBP3, are associated with risk of Alzheimer disease (AD), using a mendelian randomization study design. METHODS: We first examined disease risk by genotypes of 9 insulin-like growth factor (IGF)-related single nucleotide polymorphisms (SNPs) using published summary genome-wide association statistics from the International Genomics of Alzheimer's Project (IGAP; n = 17,008 cases; 37,154 controls)...
December 27, 2017: Neurology
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