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https://www.readbyqxmd.com/read/29786765/analysis-of-streptomyces-ghanaensis-atcc14672-gene-ssfg_07725-for-putative-%C3%AE-butyrolactone-synthase
#1
Yuriy Kuzhyk, Halyna Mutenko, Victor Fedorenko, Bohdan Ostash
Low molecular weight signaling compounds (LMWC) are important players in regulating various aspects of Streptomyces biology. Their exact roles in certain strain will ultimately depend on overall configuration of regulatory network and thus cannot be predicted on basis of in silico studies. Here, we explored S. ghanaensis gene SSFG_07725 (afsA gh ) presumably involved in initial steps of formation of γ-butyrolactone LMWC. Disruption of afsA gh impaired aerial mycelium formation and increased the transcription of pleiotropic regulatory gene adpA gh , whereas level of moenomycin production remained virtually unaffected...
May 21, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29785540/use-of-magnetic-resonance-imaging-in-rectal-cancer-patients-society-of-abdominal-radiology-sar-rectal-cancer-disease-focused-panel-dfp-recommendations-2017
#2
Marc J Gollub, Supreeta Arya, Regina Gh Beets-Tan, Gregory dePrisco, Mithat Gonen, Kartik Jhaveri, Zahra Kassam, Harmeet Kaur, David Kim, Andrea Knezevic, Elena Korngold, Chandana Lall, Neeraj Lalwani, D Blair Macdonald, Courtney Moreno, Stephanie Nougaret, Perry Pickhardt, Shannon Sheedy, Mukesh Harisinghani
PURPOSE: To propose guidelines based on an expert-panel-derived unified approach to the technical performance, interpretation, and reporting of MRI for baseline and post-treatment staging of rectal carcinoma. METHODS: A consensus-based questionnaire adopted with permission and modified from the European Society of Gastrointestinal and Abdominal Radiologists was sent to a 17-member expert panel from the Rectal Cancer Disease-Focused Panel of the Society of Abdominal Radiology containing 268 question parts...
May 21, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29785038/reduced-peak-stimulated-growth-hormone-is-associated-with-hyperuricemia-in-obese-children-and-adolescents
#3
Shuang Liang, Dejian Zhang, Jianhong Qi, Xiaobo Song, Jiang Xue
The purpose of the study is to investigate whether reduced peak GH response to arginine-levodopa test is associated with hyperuricemia in obese children and adolescents. The study population consisted of a total sample of 78 obese and 30 normal-weight children and adolescents without known hypopituitarism. All participants underwent clinical examination and GH stimulation testing. IGF-1, lipid profile and other metabolic markers were assessed. The obese subjects were then divided into two groups according to the serum levels of uric acid...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29783967/characterization-of-a-novel-thermostable-and-xylose-tolerant-gh-39-%C3%AE-xylosidase-from-dictyoglomus-thermophilum
#4
Qi Li, Tao Wu, Zhipeng Qi, Linguo Zhao, Jianjun Pei, Feng Tang
BACKGROUND: β-D-xylosidase is a vital exoglycosidase with the ability to hydrolyze xylooligosaccharides to xylose and to biotransform some saponins by cleaving outer β-xylose. β-D-xylosidase is widely used as one of the xylanolytic enzymes in a diverse range of applications, such as fuel, food and the pharmaceutical industry; therefore, more and more studies have focused on the thermostable and xylose-tolerant β-D-xylosidases. RESULTS: A thermostable β-xylosidase gene (xln-DT) of 1509 bp was cloned from Dictyoglomus thermophilum and expressed in E...
May 21, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29782792/antimicrobial-properties-of-2d-mno-2-and-mos-2-nanomaterials-vertically-aligned-on-graphene-materials-and-ti-3-c-2-mxene
#5
Farbod Alimohammadi, Mohammad Sharifian Gh, Nuwan H Attanayake, Akila C Thenuwara, Yury Gogotsi, Babak Anasori, Daniel R Strongin
Two dimensional (2D) nanomaterials have attracted considerable attention in biomedical and environmental applications due to their antimicrobial activity. In the interest of investigating the primary antimicrobial mode-of-action of 2D nanomaterials, we studied the antimicrobial properties of MnO2 and MoS2 , toward Gram-positive and Gram-negative bacteria. Bacillus subtilis and Escherichia coli bacteria were treated individually with 100 μg/mL of randomly oriented and vertically aligned nanomaterials for 3 h in the dark...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29779204/hypertensive-disorders-of-pregnancy-and-subsequent-maternal-cardiovascular-health
#6
Nienke E Bergen, Sarah Schalekamp-Timmermans, Jolien Roos-Hesselink, Jeanine E Roeters van Lennep, Vincent V W Jaddoe, Eric A P Steegers
To examine associations between hypertensive pregnancy disorders and maternal cardiovascular disease (CVD) in later life. We examined the associations between blood pressure (BP) in pregnancy, gestational hypertension (GH) and preeclampsia (PE) with cardiovascular measurements 6 years after index pregnancy among 4912 women participating in the Generation R Study, the Netherlands. BP, left ventricular mass (LV mass), aortic root diameter (AOD), left atrial diameter, fractional shortening, and carotid-femoral pulse wave velocity (PWV)...
May 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29777415/preparation-of-biologically-active-monomeric-recombinant-zebrafish-danio-rerio-and-rainbow-trout-oncorhynchus-mykiss-recombinant-growth-hormones
#7
Ewa Ocłoń, Gili Solomon, Zvi Hayouka, Arieh Gertler
Fish growth hormones (GHs) play an important role in regulating growth, metabolism, reproduction, osmoregulation, and immunity and have thus garnered attention for their application in aquaculture. Zebrafish GH (zGH) cDNA or rainbow trout GH (rtGH) cDNA was cloned into the pMon3401 vector, expressed in MON105-competent Escherichia coli and purified to homogeneity. Their biological activity was evidenced by their ability to interact with ovine GH receptor extracellular domain and stimulate GH receptor-mediated proliferation in FDC-P1-3B9 cells stably transfected with rabbit GH receptor...
May 18, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29774620/cellulose-degradation-in-gastrophysa-viridula-coleoptera-chrysomelidae-functional-characterization-of-two-cazymes-belonging-to-glycoside-hydrolase-family-45-reveals-a-novel-enzymatic-activity
#8
André Busch, Grit Kunert, Natalie Wielsch, Yannick Pauchet
Cellulose is a major component of the primary and secondary cell walls in plants. Cellulose is considered to be the most abundant biopolymer on Earth and represents a large potential source of metabolic energy. Yet, cellulose degradation is rare and mostly restricted to cellulolytic microorganisms. Recently, various metazoans, including leaf beetles, have been found to encode their own cellulases, giving them the ability to degrade cellulose independently of cellulolytic symbionts. Here, we analyzed the cellulosic capacity of the leaf beetle Gastrophysa viridula, which typically feeds on Rumex plants...
May 17, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29770869/curcumin-inhibits-autocrine-growth-hormone-mediated-invasion-and-metastasis-by-targeting-nf-%C3%AE%C2%BAb-signaling-and-polyamine-metabolism-in-breast-cancer-cells
#9
Ajda Coker-Gurkan, Merve Celik, Merve Ugur, Elif-Damla Arisan, Pinar Obakan-Yerlikaya, Zeynep Begum Durdu, Narcin Palavan-Unsal
Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-κB. Phase I/II trial of curcumin alone or with chemotherapeutic drugs has been accomplished in pancreatic, colon, prostate and breast cancer cases. Recently, autocrine growth hormone (GH) signaling-induced cell growth, metastasis and drug resistance have been demonstrated in breast cancer. In this study, our aim was to investigate the potential therapeutic effect of curcumin by evaluating the molecular machinery of curcumin-triggered apoptotic cell death via focusing on NF-κB signaling and polyamine (PA) metabolism in autocrine GH-expressing MCF-7, MDA-MB-453 and MDA-MB-231 breast cancer cells...
May 16, 2018: Amino Acids
https://www.readbyqxmd.com/read/29769040/novel-aggrecan-variant-p-gln2364pro-causes-severe-familial-nonsyndromic-adult-short-stature-and-poor-growth-hormone-response-in-chinese-children
#10
Dandan Xu, Chengjun Sun, Zeyi Zhou, Bingbing Wu, Lin Yang, Zhuo Chang, Miaoying Zhang, Li Xi, Ruoqian Cheng, Jinwen Ni, Feihong Luo
BACKGROUND: Mutations in the aggrecan (ACAN) gene can cause short stature (with heterogeneous clinical phenotypes), impaired bone maturation, and large variations in response to growth hormone (GH) treatment. For such cases, long-term longitudinal therapy data from China are still scarce. We report that a previously unknown ACAN gene variant reduces adult height and we analyze the GH response in children from an affected large Chinese family. METHODS: Two children initially diagnosed with idiopathic short stature (ISS) and a third mildly short child from a large Chinese family presented with poor GH response...
May 16, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29768519/influence-of-growth-hormone-replacement-on-neurological-and-psychomotor-development-case-report
#11
Felipe Motta, Adriana Pasmanik Eisencraft, Lindiane Gomes Crisostomo
The height response to the use of growth hormone in short height cases has already been confirmed in the literature. The influence of the insulin-like growth factor 1 (GH-IGF1) axis components on development, function, regeneration, neuroprotection, cognition, and motor functions has been evaluated in experimental studies and in adults with central nervous system lesions. However, there is still little research on the clinical impact of hormone replacement on neurological and psychomotor development. This report presents the case of a patient with excellent weight-height recovery and, even more surprisingly, neurological and psychomotor development in response to use of growth hormone...
May 14, 2018: Einstein
https://www.readbyqxmd.com/read/29768337/variation-in-origin-of-the-long-head-of-the-biceps-brachii-tendon-in-a-cadaver-a-case-report
#12
Shuji Katsuki, Hayato Terayama, Ryuta Tanaka, Ning Qu, Osamu Tanaka, Kanae Umemoto, Kaori Suyama, Kou Sakabe
INTRODUCTION: In general, the long head of the biceps brachii (LHB) tendon arises from the supraglenoid tubercle in the shoulder joint, and it has an important stabilizing mechanism for the humeral head in the shoulder joint. This case demonstrates that even if the LHB tendon can be palpated outside of the shoulder joint, it may disappear in the intertubercular sulcus (IS) and in the glenohumeral (GH) joint because of abnormal articulation. PATIENT CONCERNS: This case involved the cadaver of an 82-year-old Japanese man (number 1936, cause of death: hepatocellular tumor), who was selected from the bodies used for gross anatomy practice at the Tokai University School of Medicine in 2017...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767666/the-genome-sequence-of-dyella-jiangningensis-fcav-scs01-from-a-lignocellulose-decomposing-microbial-consortium-metagenome-reveals-potential-for-biotechnological-applications
#13
Joana G Desiderato, Danillo O Alvarenga, Milena T L Constancio, Lucia M C Alves, Alessandro M Varani
Cellulose and its associated polymers are structural components of the plant cell wall, constituting one of the major sources of carbon and energy in nature. The carbon cycle is dependent on cellulose- and lignin-decomposing microbial communities and their enzymatic systems acting as consortia. These microbial consortia are under constant exploration for their potential biotechnological use. Herein, we describe the characterization of the genome of Dyella jiangningensis FCAV SCS01, recovered from the metagenome of a lignocellulose-degrading microbial consortium, which was isolated from a sugarcane crop soil under mechanical harvesting and covered by decomposing straw...
May 14, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29767079/gluconeogenesis-during-starvation-and-refeeding-phase-is-affected-by-previous-dietary-carbohydrates-levels-and-a-glucose-stimuli-during-early-life-in-siberian-sturgeon-acipenser-baerii
#14
Xiaofang Liang, Jia Wang, Guan Gong, Min Xue, Yingchao Dong, Xiufeng Wu, Xin Wang, Chunshan Chen, Xufang Liang, Yuchang Qin
Gluconeogenesis responses was assessed during a short starvation period and subsequent refeeding in Siberian sturgeon ( Acipenser baerii ) previously fed different dietary carbohydrates levels and experienced to a glucose stimuli during early life. The sturgeon larvae were previously fed either a high glucose diet (G) or a low glucose diet (F) from the first feeding to yolk absorption (8 to 12 d post-hatching [dph]). Each group of fish was sub-divided into 2 treatments at 13 dph and was fed either a high-carbohydrate diet (H) or a low carbohydrate diet (L) until 20 wk...
September 2017: Animal nutrition
https://www.readbyqxmd.com/read/29764317/generatehope-a-comprehensive-treatment-model-for-sex-trafficked-women
#15
Susan Munsey, Heather E Miller, Terence Rugg
GenerateHope (GH) is a San Diego-based 501c3 nonprofit organization providing fully integrated, comprehensive rehabilitation services to adult female survivors of sex trafficking. While best practices for working with survivors of sex trafficking are slowly emerging, to date, there have been few publications on this subject and little data on either short- or long-term outcomes from the many and varied programs nationwide. This paper examines the GH residential program and provides early outcome results for residents living at the GH program between six and 12 months...
May 15, 2018: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/29763375/chromosomal-architecture-and-placental-expression-of-the-human-growth-hormone-gene-family-are-targeted-by-pre-pregnancy-maternal-obesity
#16
Yan Jin, Hana Vakili, SongYan Liu, Savas Menticoglou, Margaret E Bock, Peter A Cattini
The human (h) placental lactogenic hormone chorionic somatomammotropin (CS) is highly produced during pregnancy and acts as a metabolic adaptor in response to maternal insulin resistance. Maternal obesity can exacerbate this "resistance" and a >75% decrease in CS RNA levels was observed in term placentas from obese versus lean women. The genes coding for hCS (hCS-A and hCS-B) and placental growth hormone (hGH-V) as well as the hCS-L pseudogene and pituitary growth hormone (GH) gene (hGH-N) are located at a single locus on chromosome 17...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29762475/growth-hormone-secretion-patterns-in-german-landrace-dl-fetuses-and-piglets-compared-to-dl-piglets-with-inherited-1-25-dihydroxyvitamin-d3-deficiency
#17
Manfred Mielenz, Michael W Pfaffl, Christina Schlumbohm, Johein Harmeyer, Nahid Parvizi
The regulation of growth hormone (GH) release during prenatal development and during early postnatal life is not entirely clarified. In this study plasma GH concentrations in pigs with inherited pseudo vitamin D deficiency type I (PDDR-I), which regularly show growth retardation, were compared during ontogeny with unaffected pigs of the same breed (German Landrace, DL) as control. Plasma GH concentrations were measured in plasma of chronically catheterized fetuses (beginning on day 101 after mating or after artificial insemination) and in piglets (day 37 postpartum (p...
May 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29759686/molecular-mechanisms-governing-embryonic-differentiation-of-pituitary-somatotropes
#18
REVIEW
Buffy S Ellsworth, Caitlin E Stallings
Pituitary somatotropes secrete growth hormone (GH), which is essential for normal growth and metabolism. Somatotrope defects result in GH deficiency (GHD), leading to short stature in childhood and increased cardiovascular morbidity and mortality in adulthood. Current hormone replacement therapies fail to recapitulate normal pulsatile GH secretion. Stem cell therapies could overcome this problem but are dependent on a thorough understanding of somatotrope differentiation. Although several transcription factors, signaling pathways, and hormones that regulate this process have been identified, the mechanisms of action are not well understood...
May 11, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29756571/the-mechanism-of-dietary-protein-modulation-of-bone-metabolism-via-alterations-in-members-of-the-gh-igf-axis
#19
Chen Lv, Songcai Liu, Jichao Xia, Lei Xu, Yunyun Cheng, Wenyue Li, Yu Zhang, Gang Wang, Wenzhen Wei, Hongyu Shi, Shan Huang, Nan Wang, Linlin Hao
Dietary protein intake as a critical regulatory factor of bone metabolism is a vital element to regulate nutritional status of mammals. Under the action of protease, dietary protein is digested into peptides and free amino acids (FAAs). Then, the metabolites are absorbed by enterocytes and metabolized in various organs of mammals. The dietary protein intake regulates bone metabolism generally via two aspects, dietary itself and signaling transduction. At the dietary level, different kinds of amino acids (AAs) of dietary protein may affect various protein metabolism of bone by regulating proteasome depending on proteolysis and protein synthesis...
May 14, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29756419/growth-hormone-and-aging-updated-review
#20
REVIEW
Andrzej Bartke
Role of growth hormone (GH) in mammalian aging is actively explored in clinical, epidemiological, and experimental studies. The age-related decline in GH levels is variously interpreted as a symptom of neuroendocrine aging, as one of causes of altered body composition and other unwelcome symptoms of aging, or as a mechanism of natural protection from cancer and other chronic diseases. Absence of GH signals due to mutations affecting anterior pituitary development, GH secretion, or GH receptors produces an impressive extension of longevity in laboratory mice...
May 11, 2018: World Journal of Men's Health
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