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New Treatments of Sleep Apnea

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https://www.readbyqxmd.com/read/28075423/effects-of-device-guided-slow-breathing-training-on-exercise-capacity-cardiac-function-and-respiratory-patterns-during-sleep-in-male-and-female-patients-with-chronic-heart-failure
#1
Kalina Kawecka-Jaszcz, Grzegorz Bilo, Tomasz Drożdż, Dorota Dębicka-Dąbrowska, Grzegorz Kiełbasa, Gabriella Malfatto, Katarzyna Styczkiewicz, Carolina Lombardi, Agnieszka Bednarek, Sabrina Salerno, Danuta Czarnecka, Gianfranco Parati
INTRODUCTION    Slow breathing training (SBT) has been proposed as new non-pharmacological treatment in chronic heart failure (CHF) patients.  OBJECTIVES    The aim of this study was to assess the effects of SBT on exercise capacity, haemodynamic parameters and sleep respiratory patterns in a relatively large sample of CHF patients. PATIENTS ABD METHODS    A cross-over open study was conducted. The patients completed, in random order, 10-12 week periods of SBT with the RESPeRATE device (InterCure Ltd...
January 10, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28038795/sleep-apnea-and-driving-recommendations-for-interpreting-spanish-regulations-for-drivers
#2
Joaquín Terán-Santos, Carlos Egea Santaolalla, Jose María Montserrat, Fernando Masa Jiménez, Maria Villar Librada Escribano, Enrique Mirabet, Elena Valdés Rodríguez
Road traffic accidents are one of the main causes of death worldwide and are clearly associated with sleepiness. Individuals with undiagnosed sleep apnea-hypopnea syndrome (SAHS) are among the population with a high risk of experiencing sleepiness at the wheel and, consequently, road traffic accidents. Treatment with continuous positive airway pressure (CPAP) has been shown to reduce the risk of accidents among drivers with SAHS. For this reason, the European Union has included this disease in the psychological and physical criteria for obtaining or renewing a driving license...
December 27, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28025918/outcomes-of-upper-airway-stimulation-for-obstructive-sleep-apnea-in-a-multicenter-german-postmarket-study
#3
Clemens Heiser, Joachim T Maurer, Benedikt Hofauer, J Ulrich Sommer, Annemarie Seitz, Armin Steffen
Objective Selective stimulation of the hypoglossal nerve is a new surgical therapy for obstructive sleep apnea, with proven efficacy in well-designed clinical trials. The aim of the study is to obtain additional safety and efficacy data on the use of selective upper airway stimulation during daily clinical routine. Study Design Prospective single-arm study. Setting Three tertiary hospitals in Germany (Munich, Mannheim, Lübeck). Subjects and Methods A multicenter prospective single-arm study under a common implant and follow-up protocol took place in 3 German centers (Mannheim, Munich, Lübeck)...
December 1, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28019716/assessment-by-airway-ellipticity-on-cine-mri-to-differentiate-severe-obstructive-sleep-apnea
#4
Tsukasa Kojima, Masateru Kawakubo, Mari K Nishizaka, Anita Rahmawati, Shin-Ichi Ando, Akiko Chishaki, Yasuhiko Nakamura, Michinobu Nagao
INTRODUCTION: The severity of obstructive sleep apnea (OSA) is assessed by the apnea-hypopnea-index (AHI) determined from polysomnography (PSG). However, PSG requires a specialized facility with well-trained specialists and takes overnight. Therefore, simple tools, which could distinguish severe OSA, have been needed before performing PSG. OBJECTIVES: We propose the new index using cine-MRI as a screening test to differentiate severe OSA patients, who would need PSG and proper treatment...
December 26, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27997271/improvement-in-physical-activity-in-persons-with-obstructive-sleep-apnea-treated-with-continuous-positive-airway-pressure
#5
Raymonde E Jean, Manideep Duttuluri, Charlisa D Gibson, Sadaf Mir, Katherine Fuhrmann, Edward Eden, Azhar Supariwala
BACKGROUND: Exercise improves sleep quality, yet people with untreated obstructive sleep apnea (OSA) may engage in less physical activity (PA) due to fatigue and daytime sleepiness. We examined changes in PA and sleep quality before and after treatment with continuous positive airway pressure (CPAP) in OSA patients. METHODS: In this prospective longitudinal study, persons with a primary diagnosis of OSA were enrolled at a community-based hospital in New York City...
December 20, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27933351/-modern-modifications-of-uvulopalatopharyngoplasty
#6
T Verse, B A Stuck
Uvulopalatopharyngoplasty (UPPP) was first described in 1964 with regard to surgical treatment of snoring and in 1981 with regard to treatment of obstructive sleep apnea (OSA). The initial surgical techniques for OSA were very invasive, frequently leading to significant morbidity and complications. Wolfgang Pirsig et al. were the first in Germany to recognize that a radical surgical technique increased only the complications, not the efficacy of UPPP. The less invasive surgical technique developed based on these findings is still established in Germany...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27914493/patient-factors-associated-with-quality-of-life-in-atrial-fibrillation
#7
Tiffany C Randolph, DaJuanicia N Simon, Laine Thomas, Larry A Allen, Gregg C Fonarow, Bernard J Gersh, Peter R Kowey, James A Reiffel, Gerald V Naccarelli, Paul S Chan, John A Spertus, Eric D Peterson, Jonathan P Piccini
BACKGROUND: As treatment options for atrial fibrillation (AF) increase, more attention is focused on patients' experiences and quality of life (QoL). However, little is known about the factors associated with these outcomes. METHODS: The Atrial Fibrillation Effect on QualiTy-of-life (AFEQT) is a disease-specific QoL tool for AF, with domain and summary scores ranging from 0 (the worst QoL) to 100. Using multivariable linear regression, we evaluated factors associated with baseline AFEQT Summary and Subscale Scores in ORBIT AF, a large, community-based AF registry...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27909989/orexin-and-central-modulation-of-cardiovascular-and-respiratory-function
#8
Pascal Carrive, Tomoyuki Kuwaki
Orexin makes an important contribution to the regulation of cardiorespiratory function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate, sympathetic nerve activity, and the amplitude and frequency of respiration. This is consistent with the location of orexin neurons in the hypothalamus and the distribution of orexin terminals at all levels of the central autonomic and respiratory network. These cardiorespiratory responses are components of arousal and are necessary to allow the expression of motivated behaviors...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27878543/a-new-predictive-model-for-continuous-positive-airway-pressure-in-the-treatment-of-obstructive-sleep-apnea
#9
Matthew R Ebben, Mariya Narizhnaya, Ana C Krieger
BACKGROUND: Numerous mathematical formulas have been developed to determine continuous positive airway pressure (CPAP) without an in-laboratory titration study. Recent studies have shown that style of CPAP mask can affect the optimal pressure requirement. However, none of the current models take mask style into account. Therefore, the goal of this study was to develop new predictive models of CPAP that take into account the style of mask interface. METHODS: Data from 200 subjects with attended CPAP titrations during overnight polysomnograms using nasal masks and 132 subjects using oronasal masks were randomized and split into either a model development or validation group...
November 22, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27875929/introducing-a-new-concept-in-obstructive-sleep-apnea-the-continuum-of-treatment
#10
Victor Certal, Macario Camacho, Sungjin A Song, Robson Capasso
No abstract text is available yet for this article.
November 22, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27864139/evening-and-morning-peroxiredoxin-2-redox-oligomeric-state-changes-in-obstructive-sleep-apnea-red-blood-cells-correlation-with-polysomnographic-and-metabolic-parameters
#11
Amélia Feliciano, Fátima Vaz, Vukosava M Torres, Cristina Valentim-Coelho, Rita Silva, Vesna Prosinecki, Bruno M Alexandre, Ana S Carvalho, Rune Matthiesen, Atul Malhotra, Paula Pinto, Cristina Bárbara, Deborah Penque
We have examined the effects of Obstructive Sleep Apnea (OSA) on red blood cell (RBC) proteome variation at evening/morning day time to uncover new insights into OSA-induced RBC dysfunction that may lead to OSA manifestations. Dysregulated proteins mainly fall in the group of catalytic enzymes, stress response and redox regulators such as peroxiredoxin 2 (PRDX2). Validation assays confirmed that at morning the monomeric/dimeric forms of PRDX2 were more overoxidized in OSA RBC compared to evening samples. Six month of positive airway pressure (PAP) treatment decreased this overoxidation and generated multimeric overoxidized forms associated with chaperone/transduction signaling activity of PRDX2...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27829262/-upper-airway-stimulation-in-osa
#12
B Bender
Anatomical basis of obstructive sleep apnea (OSA) is the collapse of the pharynx during sleep. It is considered as a result of complex interactions of structural and neuromuscular factors. Depth of sleep and body position have modulating effects. Although different areas of obstruction were identified, studies show that the sleep-mediated obstruction frequently occurs in the base of tongue area.Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnea syndrome (OSAS) since more than 30 years...
November 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27827006/did-napoleon-suffer-from-chronic-rhonchopathy
#13
Claude-Henri Chouard
CONCLUSION: If Napoleon had been treated, Europa would then have doubtless been different, and perhaps would not have known the last two World wars. OBJECTIVES: This study plans to demonstrate that Napoleon very probably suffered from Chronic Rhonchopathy. BACKGROUND: Between 1983-1993, the author led their ENT department of CHU Saint-Antoine to contribute in the knowledge of chronic snoring and Obstructive Sleep Apneas Syndrome (OSAS), and to define the treatment of their consequences...
November 9, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27822340/stem-progenitor-cells-and-obstructive-sleep-apnea-syndrome-new-insights-for-clinical-applications
#14
REVIEW
Miruna Mihaela Micheu, Ana-Maria Rosca, Oana-Claudia Deleanu
Obstructive sleep apnea syndrome (OSAS) is a widespread disorder, characterized by recurrent upper airway obstruction during sleep, mostly as a result of complete or partial pharyngeal obstruction. Due to the occurrence of frequent and regular hypoxic events, patients with OSAS are at increased risk of cardiovascular disease, stroke, metabolic disorders, occupational errors, motor vehicle accidents and even death. Thus, OSAS has severe consequences and represents a significant economic burden. However, some of the consequences, as well as their costs can be reduced with appropriate detection and treatment...
October 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27784415/validation-of-the-system-one-remstar-auto-a-flex-for-obstructive-sleep-apnea-treatment-and-detection-of-residual-apnea-hypopnea-index-a-european-randomized-trial
#15
Frédéric Gagnadoux, Dirk Pevernagie, Poul Jennum, Nina Lon, Corinne Loiodice, Renaud Tamisier, Petra van Mierlo, Wojciech Trzepizur, Martina Neddermann, Annika Machleit, Jeffrey Jasko, Jean Louis Pépin
STUDY OBJECTIVES: Autotitrating continuous positive airway pressure (CPAP) devices adjust pressure in response to changes in airflow and are an alternative to attended in-laboratory titration polysomnography (PSG) to determine optimal pressure levels. The aim of this study was to compare the performance of the System One RemStar Auto A-Flex (Philips Respironics, Murrysville, PA, USA) automatically adjusted positive airway pressure (APAP) mode to manually titrated, fixed pressure CPAP and to validate the device's breathing event detection capabilities against attended in-laboratory PSG...
October 20, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27782591/a-new-system-for-continuous-and-remote-monitoring-of-patients-receiving-home-mechanical-ventilation
#16
L Battista
Home mechanical ventilation is the treatment of patients with respiratory failure or insufficiency by means of a mechanical ventilator at a patient's home. In order to allow remote patient monitoring, several tele-monitoring systems have been introduced in the last few years. However, most of them usually do not allow real-time services, as they have their own proprietary communication protocol implemented and some ventilation parameters are not always measured. Moreover, they monitor only some breaths during the whole day, despite the fact that a patient's respiratory state may change continuously during the day...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27775149/amitriptyline-dose-and-treatment-outcomes-in-specialty-headache-practice-a-retrospective-cohort-study
#17
Lauren Doyle Strauss, Emma Weizenbaum, Elizabeth W Loder, Paul B Rizzoli
OBJECTIVE: To characterize treatment patterns and real world outcomes in headache patients treated with amitriptyline in an academic headache center. DESIGN AND METHODS: A retrospective chart review identified 178 patients in our center who were given a new prescription for amitriptyline in treatment of headache, and who were seen in follow-up within one year. Charts were reviewed to identify dosing patterns (initial and maximum dose) and persistence, patient-reported headache benefit, and reported side effects...
November 2016: Headache
https://www.readbyqxmd.com/read/27754279/hw-03-2-effect-of-cpap-on-the-treatment-of-resistant-hypertension
#18
Seong Hwan Kim
Resistant hypertension is defined as blood pressure that remains above 140/90 mmHg in spite of the concurrent use of three antihypertensive agents of different classes at optimal dosing, of which one should be a diuretic. Accordingly, it is not synonymous with uncontrolled hypertension. Among a variety of risk factors, obstructive sleep apnea (OSA), which is a common type of sleep-disordered breathing, has been recognized a well-established risk factor for resistant hypertension. Indeed, both European and American guidelines for the management of arterial hypertension stated that OSA is a modifiable cause of resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754274/sy-17-4-neuro-immune-communication-in-hypertension-a-new-therapeutic-angle
#19
Mohan Raizada
Hypertension (HTN) is the most prevalent modifiable risk for cardiovascular disease (CVD) and disorders directly influencing CVD (i.e. obesity, diabetes, chronic kidney disease, obstructive sleep apnea, etc.). About one billion people worldwide have HTN, with American adults having 90% lifetime risk of developing HTN. Despite aggressive campaign for lifestyle changes and advances in drug therapy, HTN remains an immense health, emotional, and economic challenge. This is due, in part, to the fact that ∼50% of HTN patients' blood pressure remains uncontrolled and ∼20% of HTN patients are resistant to or require > antihypertensive drugs...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753975/os-12-02-sleep-apnea-cardiovascular-endpoints-save-study-an-international-randomised-controlled-trial-to-determine-whether-continuous-positive-airways-pressure-treatment-for-obstructive-sleep-apnea-in-patients-with-cv-disease-prevents-secondary-cardiovascular
#20
Craig Anderson, Doug McEvoy, Jiguang Wang
OBJECTIVE: There is uncertainty over whether treatment of obstructive sleep apnea (OSA) can prevent serious cardiovascular (CV) events. DESIGN AND METHOD: SAVE (NCT00738179; ACTRN12608000409370) was designed to determine whether treatment of OSA with CPAP reduces the risk of serious CV events in patients with established CV disease. Participants were centrally randomised to CPAP treatment or usual care between 2008 and 2013,with follow-up completed late 2015 and the results will be announced in August 2016...
September 2016: Journal of Hypertension
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